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Wyświetlanie 1-15 z 27
Tytuł:
Evaluation of hydrophilic globules with sodium alginate containing a lactic acid– chitosan complex
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/2131517.pdf
Data publikacji:
2021
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
hydrophilic globules
lactic acid-chitosan complex
physiological environment of vagina
vaginal mucosa
vaginal infections
Opis:
An important issue in the treatment of vaginitis is the amount of time the drug remains on the vaginal mucosa. If the contact time is too short, the drug cannot work effectively to ensure the correct pH in the vaginal environment. This study evaluated formulations of globules containing sodium alginate, lactic acid and chitosan with different pH and rheological properties. The experimental studies revealed that it is possible to produce a preparation with optimal pharmaceutical and application properties. The use of an appropriate ratio of lactic acid to chitosan in the complex and the appropriate concentration of sodium alginate produces a preparation with excellent properties to coat the surface of the vaginal mucosa.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2021, 26; 170-177
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of pectin and chitosan on the properties of gels protecting the oesophageal mucosa
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/2131516.pdf
Data publikacji:
2021
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
gastro-oesophageal reflux
hydrophilic gels
oesophageal infections
oesophageal mucosa
physiological environment of gastro-oesophagus
Opis:
Among the diseases of the digestive tract, gastro-oesophageal reflux is one of the most troublesome ailments. It is estimated that in highly developed countries, reflux symptoms occur in about 5%-10% of people every day. It has also been found that about 20% of people experience such symptoms once a week. The incidence of this disease increases with age, regardless of gender. The aim of the study was to investigate the physicochemical properties of gels intended for the protection of the oesophageal mucosa. Preparations containing 3.0% pectin showed the lowest pH. These gels can be used in the treatment of advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of pectin concentration on the adhesion work of the tested gels.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2021, 26; 162-169
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Research of hydrophilic globules containing a lactic acid-chitosan complex
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034096.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
hydrophilic globules
lactic acid-chitosan complex
physiological environment of vagina
vaginal infections
vaginal mucosa
Opis:
Gynecological scientific journals report that traditional therapeutic regimens used to treat vaginal inflammation recommended by global treatment centers and health organizations are not producing satisfactory results. Insufficient duration of the drug’s contact with vaginal mucosa does not provide adequate pH conditioning the physiological biocenosis of the organ. The conducted research and obtained positive results encourage further research possibilities in the field of optimization of pharmaceutical properties of the examined gynecological preparations. Assuming the above assumptions tested impact of polyvinylpyrrolidone K-15, polyvinylpyrrolidone K-30 and polyvinylpyrrolidone K-90 in the properties of the globules. The study was prepared formulations with different pH and rheological properties. The device simulating the conditions in the vagina, studied the adhesion and movement of the gel on the mucosa of the organ. Globules after application of the apparatus simulates the natural conditions in the gel passes and cover the surface. A wide range of pH of the gels allows the selection of the optimum formulation.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 143-150
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of chitosan on the properties of gels protecting of the esophageal mucosa
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034174.pdf
Data publikacji:
2019
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
esophageal infections.
esophageal mucosa
gastro-esophageal reflux
hydrophilic gels
physiological environment of gastro-esophageal
Opis:
Gastro-esophageal reflux is a term that defines the reverse flow of acid gastric contents into the esophagus. On the other hand, alkaline reflux occurs in the case when alkaline intestinal contents enter the esophagus. The aim of the study was to examine the pharmaceutical properties of gels for the treatment of gastro-esophageal reflux, covering the mucosa, allowing prolonged contact with the esophageal mucosa. Formulations containing the PVP K-30 showed the lowest pH, which is an important feature and can be used in the treatment of advanced alkaline reflux. Gels containing PVP K-90 and chitosan can be used in the treatment of acid reflux. The addition of chitosan significantly increased the dynamic viscosity of the tested gels. The study of the work of adhesion showed the effect of PVP K-30 and PVP K-90 and their concentration on the value of the work of adhesion. The presented studies have shown that it is possible to obtain gels with high adhesion to the esophageal mucous membrane.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2019, 24; 135-144
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The properties of intravaginal globules containing a lactic acid-chitosan complex
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034204.pdf
Data publikacji:
2019
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
hydrophilic globules
lactic acid-chitosan complex
physiological environment of vagina
vaginal infections.
vaginal mucosa
Opis:
Continuing the implementation of research on the problem of treatment of vaginal pH disorders, intravaginal globules were examined as vaginal drug form which carries the lactic acid complexes with chitosan. The intravaginal application of globules that transform into gel under natural conditions is aimed at achieving the physiological pH of the vaginal environment. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of 1:1 and 2:1 of lactic acid to chitosan showed a pH in the physiological range at 37°C. Additional hydroxypropylmethylcellulose and excipients allows various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and hydroxypropylmethylcellulose in comparison to the gels without hydroxypropylmethylcellulose. The study of the work of adhesion showed the effect of hydroxypropylmethylcellulose and their concentration on the value of the work of adhesion.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2019, 24; 127-134
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pharmaceutical assessment of gynaecological powders with sodium alginate containing a lactic acid-chitosan complex
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034359.pdf
Data publikacji:
2018
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
hydrophilic powders
lactic acid complexed with chitosan
physiological environment of the vagina
vaginal infections.
vaginal mucosa
Opis:
The insufficient duration of the drug’s contact with the vaginal mucosa does not provide adequate pH, conditioning the physiological biocenosis of the organ. This effect is hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. This study has shown the impact of the used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. The addition of sodium alginate and excipients to these complexes allows various formulations to be obtained over a wide range of pH. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and sodium alginate in comparison to gels without sodium alginate. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2018, 23; 130-139
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of a carboxymethylcellulose sodium salt on the properties of hydrophilic powders containing a lactic acid-chitosan complex
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034366.pdf
Data publikacji:
2018
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
hydrophilic powders
lactic acid-chitosan complex
physiological environment of the vagina
vaginal infections
vaginal mucosa
Opis:
The investigated powders on a methylcellulose base revealed good adhesion to the vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of the 24-hour action of the drug. The treatment of vagina inflammatory conditions is usually long and difficult because of the frequent relapse. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of lactic acid to chitosan of 1:1 and 2:1 showed a pH in the physiological range at 37°C. Additionally, carboxymethylcellulose sodium salt and excipients allow various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and carboxymethylcellulose sodium salt in comparison to gels without carboxymethylcellulose sodium salt.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2018, 23; 120-129
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of a pectin on the properties of hydrophilic powders containing a lactic acid-chitosan complex
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034572.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
hydrophilic powders
lactic acid-chitosan complex
physiological environment of vagina
vaginal infections
vaginal mucosa
Opis:
Gynecological powders are designed to correct abnormal pH environments of the vagina and the stabilise the pH to the physiological state 3.5-5.0. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of 1:1 and 2:1 of lactic acid to chitosan showed a pH in the physiological range at 37°C. Additional pectin and excipients allows various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and pectin in comparison to the gels without pectin. Studies of work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentration on the value of the work of adhesion. The results obtained in the experimental studies demonstrated that it is possible to produce a preparation with optimal pharmaceutical and application properties.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 135-142
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The use of dextran in gynecological powders containing lactic acid complexed with chitosan
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034634.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
hydrophilic powders
lactic acid complexed with chitosan
physiological environment of vagina
vaginal infections
vaginal mucosa
Opis:
Powders for gynecological use pass under natural conditions in gels covering the vaginal mucosa. This study has shown the impact of used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. All gels with complexes in the ratios of 1:1 and 2:1 (lactic acid:chitosan) showed a pH in the physiological range 3.5-5.0 at 37°C. The addition of dextran and excipients to these complexes allows various formulations over a wide range of pH to be obtained. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and dextran in comparison to gels without dextran. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion. The presented work shows that it is possible to obtain gels with high adhesion properties to vaginal mucous membrane.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 143-150
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of pharmaceutical properties of thermosensitive gynecological powders containing lactic acid complexed with chitosan
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034637.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
lactic acid complexed with chitosan
physiological environment of vagina
thermosensitive hydrophilic powders
vaginal infections.
vaginal mucosa
Opis:
pH of gels ranged from 3.92 to 4.44 for gels 1:1 and from 2.36 to 2.84 for 8:1 ratio. The addition of 20%, 23% or 25% poloxamer 407 increases the pH ranged from 4.00 to 4.91 for gels with 1:1 ratio and from 2.56 to 3.42 for 8:1 ratio. Rheological studies demonstrated that the investigated gels obtained from powders have the dynamic viscosity ranged from 53 mPa*s to 398 mPa*s for the 1:1 stoichiometric ratio in the complex and from 19 mPa*s to 242 mPa*s for 8:1 ratio. The addition of calcium alginate with polyoxyethylene glycol-200 reduces the pH and maintains high dynamic viscosity. The thermosensitive gels obtained from thermosensitive powders shows high adhesion and are difficult to separate from the probe.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 160-164
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of poloxamer 407 on the properties gynecological powders containing lactic acid complexed with chitosan
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034722.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
lactic acid complexed with chitosan
physiological environment of vagina
thermosensitive hydrophilic powders
vaginal infections
vaginal mucosa
Opis:
Thermosensitive hydrophilic powders passing in gels containing lactic acid complexed with chitosan at a stoichiometric ratio 1:1 and 8:1 reveal pH ranged from 4.00 to 4.91 and 2.56 to 3.42. Rheological studies demonstrated that the investigated thermosensitive gels obtained from powders have the dynamic viscosity in the ranged from 269 mPa*s to 579 mPa*s for the 1:1 stoichiometric ratio and in the range from 220 mPa*s to 530 mPa*s for 8:1 ratio. As a result of the research preparations with different pH values including the physiological range were obtained. The thermosensitive gels obtained from the thermosensitive powders were characterized by the specific dynamic viscosity. The results proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 154-159
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of hydrophilic polymers on the properties of gynecological powders containing lactic acid complexed with chitosan
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034997.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
lactic acid complexed with chitosan
physiological environment of vagina
thermosensitive hydrophilic powders passing gels
vaginal infections
vaginal mucosa
Opis:
Tested impact of polyvinyl alcohol, dextrane and calcium alginate for the properties of the powders containing poloxamer 407 and lactic acid complexed with chitosan. For researches was prepared formulations with different pH and rheological properties. The thermosensitive gels obtained from thermosensitive powders possess the work of adhesion with different values. The researches revealed that the dynamic viscosity of the gels obtained from powders is high. A wide range of pH of the thermosensitive gels allows the selection of the optimum formulation. The gels obtained from the powders containing polyvinyl alcohol or dextrane or calcium alginate were characterized by the specific dynamic viscosity. The researches demonstrated that the methylcellulose with different values of the viscosity with poloxamer 407 significantly affect the adhesive properties of thermosensitive hydrophilic gels obtained from powders.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 195-203
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The properties of thermosensitive gynecological powders containing lactic acid complexed with chitosan
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1034802.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
lactic acid complexed with chitosan
physiological environment of vagina
thermosensitive hydrophilic powders passing gels
vaginal infections
vaginal mucosa
Opis:
The investigations showed that the addition of a 20%, 23% and 25% poloxamer 407 increases the adhesive properties of the investigated powders, but at the same time it increases their pH. The enrichment of the composition of the tested powders containing 5% glycerol and 5% 1,2-propylene glycol resulted in increased pH of the formulations. A modification of the composition of the tested powders containing 5% glycerol and 5% 1,2-propylene glycol has increased the range of the dynamic viscosity of formulations. The enrichment of the composition of the tested powders containing 5% hydroxypropylmethylcellulose resulted in increased the range of the dynamic viscosity and decreased pH of the formulations. Laboratory tests have shown that it is possible to obtain thermosensitive gels with high adhesion properties to vaginal mucous membrane.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 183-194
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of a chosen auxiliary substance on the properties of hydrophilic powders containing lactic acid complexed with chitosan
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1035192.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
hydrophilic powders passing gels
lactic acid complexed with chitosan
physiological environment of vagina
vaginal infections
vaginal mucosa
Opis:
Hydrophilic powders passing gels containing lactic acid complexed with chitosan at a stoichiometric ratio of 1:1 and 8:1 revealed pH ranged from 3.92 to 4.44 and 2.36 to 2.84. Rheological studies demonstrated that the research gels obtained from powders possess the dynamic viscosity ranging from 53 to 398 mPa.s for the 1:1 stoichiometric ratio in the complex and from 19 to 242 mPa.s for the 8:1 ratio. As a result of the research, preparations with different pH values, including physiological range, were obtained. Powders show that the adhesion of the gel covering the surface of the apparatus simulates the conditions in the vagina. The gels obtained from the powders were characterised by the specific dynamic viscosity and possess the work of adhesion. The results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 87-93
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pharmaceutical assessment of gynaecological powders with the addition of hydrophilising substances containing lactic acid complexed with chitosan
Autorzy:
Małolepsza-Jarmołowska, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1035187.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
anti-inflammatory drugs
hydrophilic powders passing gels
lactic acid complexed with chitosan
physiological environment of vagina
vaginal infections
vaginal mucosa
Opis:
Research on gynaecological preparations followed that of optimising their pharmaceutical properties, which is beneficial for gynaecological powders. Gels obtained from powders containing lactic acid complexed with chitosan revealed a stoichiometric ratio 1:1, 2;1, 3:1, 4:1 and 8:1. Their pH ranged from 3.92 to 4.44 for 1:1 gels and from 2.36 to 2.84 for the 8:1 ratio. The addition of 5% polyethylene glycol-400 increases the pH from 4.52 to 4.92 for 1:1 gels and from 2.54 to 3.41 for the 8:1 ratio. A modification of the composition of the tested powders containing 5% polyethylene glycol-400 increased the range of the dynamic viscosity of formulations suitably from 78 to 520 mPa.s for 1:1 gels and from 39 to 423 mPa.s for the 8:1 ratio. Measurements performed in a biopharmaceutical model revealed that the gels obtained from powders containing lactic acid complexed with chitosan are able to move from 25 to 28 cm.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 95-101
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 27

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