- Tytuł:
- Assessment of pharmaceutical properties of gynaecological hydrophilic gels containing lactic acid complexed with chitosan
- Autorzy:
- Małolepsza-Jarmołowska, Katarzyna
- Powiązania:
- https://bibliotekanauki.pl/articles/1035397.pdf
- Data publikacji:
- 2012
- Wydawca:
- Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
- Tematy:
-
1
2- propylene glycol
anti-inflammatory drugs.
glycerol
lactic acid complexed with chitosan
thermosensitive polymer - poloxamer 407
vaginal infections - Opis:
- Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5-25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm. The addition of glycerol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 23 cm to 26 cm and at 2:1 ratio from 25 cm to 29 cm. Gels with addition 20-25% poloxamer 407 containing lactic acid complexed with chitosan and 5-25% content of glycerol reveal pH from 4.25 to 4.98 for 1:1 and from 3.60 to 4.45 for 2:1. The investigations showed that the addition of a thermosensitive polymer increases the adhesive properties of the investigated gels, but at the same time it increases their pH. The addition of glycerol or 1,2-propylene glycol reduces the pH and maintains high adhesion. The use of hydrofilizing substances allowed to obtain physiological range pH gynaecological gels.
- Źródło:
-
Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 117-124
1896-5644 - Pojawia się w:
- Progress on Chemistry and Application of Chitin and its Derivatives
- Dostawca treści:
- Biblioteka Nauki
Artykuł