- Tytuł:
- Assessment of pharmaceutical properties of thermosensitive gynecological powders containing lactic acid complexed with chitosan
- Autorzy:
- Małolepsza-Jarmołowska, Katarzyna
- Powiązania:
- https://bibliotekanauki.pl/articles/1034637.pdf
- Data publikacji:
- 2016
- Wydawca:
- Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
- Tematy:
-
anti-inflammatory drugs
lactic acid complexed with chitosan
physiological environment of vagina
thermosensitive hydrophilic powders
vaginal infections.
vaginal mucosa - Opis:
- pH of gels ranged from 3.92 to 4.44 for gels 1:1 and from 2.36 to 2.84 for 8:1 ratio. The addition of 20%, 23% or 25% poloxamer 407 increases the pH ranged from 4.00 to 4.91 for gels with 1:1 ratio and from 2.56 to 3.42 for 8:1 ratio. Rheological studies demonstrated that the investigated gels obtained from powders have the dynamic viscosity ranged from 53 mPa*s to 398 mPa*s for the 1:1 stoichiometric ratio in the complex and from 19 mPa*s to 242 mPa*s for 8:1 ratio. The addition of calcium alginate with polyoxyethylene glycol-200 reduces the pH and maintains high dynamic viscosity. The thermosensitive gels obtained from thermosensitive powders shows high adhesion and are difficult to separate from the probe.
- Źródło:
-
Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 160-164
1896-5644 - Pojawia się w:
- Progress on Chemistry and Application of Chitin and its Derivatives
- Dostawca treści:
- Biblioteka Nauki