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    Wyświetlanie 1-12 z 12
    Tytuł:
    Influence of a pectin on the properties of hydrophilic powders containing a lactic acid-chitosan complex
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1034572.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders
    lactic acid-chitosan complex
    physiological environment of vagina
    vaginal infections
    vaginal mucosa
    Opis:
    Gynecological powders are designed to correct abnormal pH environments of the vagina and the stabilise the pH to the physiological state 3.5-5.0. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of 1:1 and 2:1 of lactic acid to chitosan showed a pH in the physiological range at 37°C. Additional pectin and excipients allows various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and pectin in comparison to the gels without pectin. Studies of work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentration on the value of the work of adhesion. The results obtained in the experimental studies demonstrated that it is possible to produce a preparation with optimal pharmaceutical and application properties.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 135-142
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The use of dextran in gynecological powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1034634.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders
    lactic acid complexed with chitosan
    physiological environment of vagina
    vaginal infections
    vaginal mucosa
    Opis:
    Powders for gynecological use pass under natural conditions in gels covering the vaginal mucosa. This study has shown the impact of used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. All gels with complexes in the ratios of 1:1 and 2:1 (lactic acid:chitosan) showed a pH in the physiological range 3.5-5.0 at 37°C. The addition of dextran and excipients to these complexes allows various formulations over a wide range of pH to be obtained. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and dextran in comparison to gels without dextran. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion. The presented work shows that it is possible to obtain gels with high adhesion properties to vaginal mucous membrane.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 143-150
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The effect of a carboxymethylcellulose sodium salt on the properties of hydrophilic powders containing a lactic acid-chitosan complex
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1034366.pdf
    Data publikacji:
    2018
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders
    lactic acid-chitosan complex
    physiological environment of the vagina
    vaginal infections
    vaginal mucosa
    Opis:
    The investigated powders on a methylcellulose base revealed good adhesion to the vaginal mucosa and were present on it throughout the daily activities of the patient. This property enabled the continuity of the 24-hour action of the drug. The treatment of vagina inflammatory conditions is usually long and difficult because of the frequent relapse. Powders were transformed into gels and were tested for their properties. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of lactic acid to chitosan of 1:1 and 2:1 showed a pH in the physiological range at 37°C. Additionally, carboxymethylcellulose sodium salt and excipients allow various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and carboxymethylcellulose sodium salt in comparison to gels without carboxymethylcellulose sodium salt.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2018, 23; 120-129
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pharmaceutical assessment of gynaecological powders with sodium alginate containing a lactic acid-chitosan complex
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1034359.pdf
    Data publikacji:
    2018
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders
    lactic acid complexed with chitosan
    physiological environment of the vagina
    vaginal infections.
    vaginal mucosa
    Opis:
    The insufficient duration of the drug’s contact with the vaginal mucosa does not provide adequate pH, conditioning the physiological biocenosis of the organ. This effect is hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. This study has shown the impact of the used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. The addition of sodium alginate and excipients to these complexes allows various formulations to be obtained over a wide range of pH. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and sodium alginate in comparison to gels without sodium alginate. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2018, 23; 130-139
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Assessment of pharmaceutical properties of thermosensitive gynecological powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1034637.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    lactic acid complexed with chitosan
    physiological environment of vagina
    thermosensitive hydrophilic powders
    vaginal infections.
    vaginal mucosa
    Opis:
    pH of gels ranged from 3.92 to 4.44 for gels 1:1 and from 2.36 to 2.84 for 8:1 ratio. The addition of 20%, 23% or 25% poloxamer 407 increases the pH ranged from 4.00 to 4.91 for gels with 1:1 ratio and from 2.56 to 3.42 for 8:1 ratio. Rheological studies demonstrated that the investigated gels obtained from powders have the dynamic viscosity ranged from 53 mPa*s to 398 mPa*s for the 1:1 stoichiometric ratio in the complex and from 19 mPa*s to 242 mPa*s for 8:1 ratio. The addition of calcium alginate with polyoxyethylene glycol-200 reduces the pH and maintains high dynamic viscosity. The thermosensitive gels obtained from thermosensitive powders shows high adhesion and are difficult to separate from the probe.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 160-164
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of poloxamer 407 on the properties gynecological powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1034722.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    lactic acid complexed with chitosan
    physiological environment of vagina
    thermosensitive hydrophilic powders
    vaginal infections
    vaginal mucosa
    Opis:
    Thermosensitive hydrophilic powders passing in gels containing lactic acid complexed with chitosan at a stoichiometric ratio 1:1 and 8:1 reveal pH ranged from 4.00 to 4.91 and 2.56 to 3.42. Rheological studies demonstrated that the investigated thermosensitive gels obtained from powders have the dynamic viscosity in the ranged from 269 mPa*s to 579 mPa*s for the 1:1 stoichiometric ratio and in the range from 220 mPa*s to 530 mPa*s for 8:1 ratio. As a result of the research preparations with different pH values including the physiological range were obtained. The thermosensitive gels obtained from the thermosensitive powders were characterized by the specific dynamic viscosity. The results proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 154-159
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Research of pharmaceutical properties of hydrophilic powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1035180.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders passing gels
    lactic acid complexed with chitosan
    physiological environment of vagina
    vaginal infections
    vaginal mucosa
    Opis:
    Hydrophilic powders passing gels containing lactic acid complexed with chitosan at a stoichiometric ratio of 1:1 and 8:1 revealed pH ranged from 3.92 to 4.44 and 2.36 to 2.84. Rheological studies demonstrated that the research gels obtained from powders possess the dynamic viscosity ranging from 53 to 398 mPa.s for the 1:1 stoichiometric ratio in the complex and from 19 to 242 mPa.s for the 8:1 ratio. As a result of the research, preparations with different pH values, including physiological range, were obtained. Powders show that the adhesion of the gel covering the surface of the apparatus simulates the conditions in the vagina. The gels obtained from the powders were characterised by the specific dynamic viscosity and possess the work of adhesion. The results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 79-85
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pharmaceutical assessment of gynaecological powders with the addition of hydrophilising substances containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1035187.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders passing gels
    lactic acid complexed with chitosan
    physiological environment of vagina
    vaginal infections
    vaginal mucosa
    Opis:
    Research on gynaecological preparations followed that of optimising their pharmaceutical properties, which is beneficial for gynaecological powders. Gels obtained from powders containing lactic acid complexed with chitosan revealed a stoichiometric ratio 1:1, 2;1, 3:1, 4:1 and 8:1. Their pH ranged from 3.92 to 4.44 for 1:1 gels and from 2.36 to 2.84 for the 8:1 ratio. The addition of 5% polyethylene glycol-400 increases the pH from 4.52 to 4.92 for 1:1 gels and from 2.54 to 3.41 for the 8:1 ratio. A modification of the composition of the tested powders containing 5% polyethylene glycol-400 increased the range of the dynamic viscosity of formulations suitably from 78 to 520 mPa.s for 1:1 gels and from 39 to 423 mPa.s for the 8:1 ratio. Measurements performed in a biopharmaceutical model revealed that the gels obtained from powders containing lactic acid complexed with chitosan are able to move from 25 to 28 cm.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 95-101
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of a chosen auxiliary substance on the properties of hydrophilic powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1035192.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders passing gels
    lactic acid complexed with chitosan
    physiological environment of vagina
    vaginal infections
    vaginal mucosa
    Opis:
    Hydrophilic powders passing gels containing lactic acid complexed with chitosan at a stoichiometric ratio of 1:1 and 8:1 revealed pH ranged from 3.92 to 4.44 and 2.36 to 2.84. Rheological studies demonstrated that the research gels obtained from powders possess the dynamic viscosity ranging from 53 to 398 mPa.s for the 1:1 stoichiometric ratio in the complex and from 19 to 242 mPa.s for the 8:1 ratio. As a result of the research, preparations with different pH values, including physiological range, were obtained. Powders show that the adhesion of the gel covering the surface of the apparatus simulates the conditions in the vagina. The gels obtained from the powders were characterised by the specific dynamic viscosity and possess the work of adhesion. The results obtained in the experimental studies proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 87-93
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Use polyvinylpyrrolidone in technology of gynaecological powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1035193.pdf
    Data publikacji:
    2014
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic powders passing gels
    lactic acid complexed with chitosan
    physiological environment of vagina
    vaginal infections.
    vaginal mucosa
    Opis:
    metric ratio of 1:1, 2:1, 3:1, 4:1 and 8:1. Their pH ranged from 3.92 to 4.44 for 1:1 gels and from 2.36 to 2.84 for the 8:1 ratio. The addition of 5% polyvinylpyrrolidone K-90 increased the pH from 4.28 to 4.52 for 1:1 and from 2.58 to 3.30 for the 8:1 ratio. The addition of 5% polyvinylpyrrolidone K-90 increased the dynamic viscosity from 84 to 510 mPa.s for 1:1 gels and from 47 to 386 mPa.s for the 8:1 ratio. The gels obtained from powders possess the work of adhesion - the energy needed to separate the gel from the probe was 15.2 g/s for gels with 5% polyvinylpyrrolidone K-15, 52.76 g/s for gels with 5% polyvinylpyrrolidone K-30, and 56.6 g/s for gels containing 5% polyvinylpyrrolidone K-90. The results proved that it is possible to produce a preparation with optimal pharmaceutical and application properties.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 103-110
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The properties of thermosensitive gynecological powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1034802.pdf
    Data publikacji:
    2015
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    lactic acid complexed with chitosan
    physiological environment of vagina
    thermosensitive hydrophilic powders passing gels
    vaginal infections
    vaginal mucosa
    Opis:
    The investigations showed that the addition of a 20%, 23% and 25% poloxamer 407 increases the adhesive properties of the investigated powders, but at the same time it increases their pH. The enrichment of the composition of the tested powders containing 5% glycerol and 5% 1,2-propylene glycol resulted in increased pH of the formulations. A modification of the composition of the tested powders containing 5% glycerol and 5% 1,2-propylene glycol has increased the range of the dynamic viscosity of formulations. The enrichment of the composition of the tested powders containing 5% hydroxypropylmethylcellulose resulted in increased the range of the dynamic viscosity and decreased pH of the formulations. Laboratory tests have shown that it is possible to obtain thermosensitive gels with high adhesion properties to vaginal mucous membrane.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 183-194
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of hydrophilic polymers on the properties of gynecological powders containing lactic acid complexed with chitosan
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1034997.pdf
    Data publikacji:
    2015
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    lactic acid complexed with chitosan
    physiological environment of vagina
    thermosensitive hydrophilic powders passing gels
    vaginal infections
    vaginal mucosa
    Opis:
    Tested impact of polyvinyl alcohol, dextrane and calcium alginate for the properties of the powders containing poloxamer 407 and lactic acid complexed with chitosan. For researches was prepared formulations with different pH and rheological properties. The thermosensitive gels obtained from thermosensitive powders possess the work of adhesion with different values. The researches revealed that the dynamic viscosity of the gels obtained from powders is high. A wide range of pH of the thermosensitive gels allows the selection of the optimum formulation. The gels obtained from the powders containing polyvinyl alcohol or dextrane or calcium alginate were characterized by the specific dynamic viscosity. The researches demonstrated that the methylcellulose with different values of the viscosity with poloxamer 407 significantly affect the adhesive properties of thermosensitive hydrophilic gels obtained from powders.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 195-203
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-12 z 12

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