Skocz do pozycji: 1.

Tytuł:

Analysis of single gene multitrait effects in livestock by the use of Gibbs sampling

Autorzy:

Dobek, A
Molinski, K.
Szydlowski, M.
Szwaczkowski, T.

Powiązania:

https://bibliotekanauki.pl/articles/2042024.pdf

Data publikacji:

2000

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

gene
gene frequency
major gene
livestock
Gibbs sampling

Źródło:

Journal of Applied Genetics; 2000, 41, 4; 275-283
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:

More Acanthamoeba Genotypes: Limits to Use rDNA Fragments to Describe New Genotype

Autorzy:

Corsaro, Daniele

Powiązania:

https://bibliotekanauki.pl/articles/763668.pdf

Data publikacji:

2011

Wydawca:

Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego

Tematy:

Acanthamoeba, genotype, full gene sequence, partial gene sequence

Opis:

Strains of the genus Acanthamoeba are usually assigned to sequence types or genotypes according to pair-wise similarity values of the nuclear gene for the small subunit of ribosomal RNA. This classification system was established by comparing full or nearly full gene sequences, > 2000 bp. For practical reasons, diagnostic fragments of smaller lengths have been identified and used for rapid and economic identification of large number of strains. While the use of these small fragments in diagnostics applications remains valid when and only if the reference full sequence-type is available, we contest their use to identify and describe new genotypes. We report herein the case of a new genotype described on the basis of solely a small partial sequence and discuss the poor reliability of this fragment to correctly infer phylogenetic relationships, and its limits in the description of new genotypes of Acanthamoeba.

Źródło:

Acta Protozoologica; 2011, 50, 1
1689-0027

Pojawia się w:

Acta Protozoologica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 3.

Tytuł:

Antiangiogenic gene therapy in inhibition of metastasis.

Autorzy:

Szala, Stanisław
Szary, Jarosław
Cichoń, Tomasz
Sochanik, Aleksander

Powiązania:

https://bibliotekanauki.pl/articles/1043756.pdf

Data publikacji:

2002

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

antiangiogenic gene therapy
encapsulation
inducible gene expression
metastasis

Opis:

This short review attempts to demonstrate the usefulness of antiangiogenic gene therapy in achieving inhibition of growth in experimentally-induced metastases. Certain normal tissues (for example skeletal muscle) may be used in vivo, after genetic modification, as a "bioreactor", able to produce and secrete into the bloodstream proteins known to exert antiangiogenic effects. By inhibiting neoangiogenesis these proteins would thus prevent the development of metastases. The review discusses also the perspectives of antimetastatic therapy based on certain types of allogenic cells (for example myoblasts and fibroblasts) that had been genetically modified and then microencapsulated. The strategy of encapsulation is aimed at protecting the modified cells secreting antiangiogenic factors from being eliminated by the immune system. Secretion of antiangiogenic proteins by these microencapsulated cells can be controlled with inducible promoters. Antiangiogenic genes remaining under the transcriptional control of such promoters may be switched on and off using antibiotics, such as tetracycline derivatives, or steroid hormones.

Źródło:

Acta Biochimica Polonica; 2002, 49, 2; 313-321
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 4.

Tytuł:

Association of CAST and RYR1 genes polymorphism with carcass and meat quality in crossbreed pigs with a share of Pietrain breed
Zależność polimorfizmu genów CAST i RYR1 z cechami jakości tuszy i mięsa u świń mieszańców z udziałem rasy pietrain

Autorzy:

Rybarczyk, A.
Terman, A.
Zak, G.
Kumalska, M.
Polasik, D.

Powiązania:

https://bibliotekanauki.pl/articles/2783.pdf

Data publikacji:

2016

Wydawca:

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie

Tematy:

CAST gene
RYR1 gene
gene polymorphism
carcass
meat quality
crossbreed
pig
Pietrain breed

Opis:

Association of CAST and RYR1 genes polymorphism with carcass and meat quality in crossbreed pigs with a share of Pietrain breed. The aim of this study was to determine the effect of the calpastatin (CAST/TaqI) and ryanodine receptor (RYR1) genes polymorphism on carcass and meat quality traits in Pietrain crossbred pigs. The polymorphism in CAST and RYR1 genes was detected using the PCR-RFLP (Restriction Fragment Length Polymorphism Analysis of PCR-Amplified Fragments) method. Two alleles of CAST gene were identified–A(0.34) and B (0.66) and three genotypes–AA(0.21), AB (0.25) and BB (0.54). In relation to carcass and pork quality, no statistically significant differences were found between the CT and CC genotypes of RYR1 gene as well as between AA, AB and BB genotypes of CASTgene. In addition, no significant interaction was found between CAST/TaqI × RYR1 genotypes and all the analyzed carcass and meat quality traits.
Zależność polimorfizmu genów CAST i RYR1 z cechami jakości tuszy i mięsa u świń mieszańców z udziałem rasy Pietrain. Celem niniejszych badań było określenie wpływu polimorfizmu genów kalpastatyny (CAST/TaqI) i receptora ryanodiny (RYR1) na cechy jakości tuszy i mięsa u świń mieszańców rasy pietrain. Polimorfizm genów CAST i RYR1 określono za pomocą metody PCR-RFLP (analiza polimorfizmu fragmentów restrykcyjnych amplifikowanych metodą PCR). Zidentyfikowano 2 allele –A (0.34) i B (0.66) oraz 3 genotypy genu CAST– AA(0.21), AB (0.25) i BB (0.54). W odniesieniu do jakości tuszy i mięsa nie zaobserwowano statystycznie istotnych różnic pomiędzy genotypami CT i CC genu RYR1 jak również genotypamiAA, AB i BB genuCAST. Dodatkowo nie stwierdzono istotnych interakcji pomiędzy genotypami CAST/TaqI × RYR1,a wszystkimi ocenianymi cechami jakości tuszy i mięsa.

Źródło:

Annals of Warsaw University of Life Sciences - SGGW. Animal Science; 2016, 55[2]
1898-8830

Pojawia się w:

Annals of Warsaw University of Life Sciences - SGGW. Animal Science

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:

The effect of phenobarbital on gene expression levels of p53 and DNMT1 in the liver of Wistar rats

Autorzy:

Urbanek-Olejnik, K.
Liszewska, M.
Kostka, G.

Powiązania:

https://bibliotekanauki.pl/articles/874211.pdf

Data publikacji:

2014

Wydawca:

Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny

Tematy:

phenobarbital
gene expression
animal exposure
rat
p53 gene
Dnmt1 gene
liver
Wistar rat

Opis:

Background. Our previous studies have shown that short-term treatment with phenobarbital (PB) resulted in cytosine methylation of CpG sites on the p53 gene promoter in male Wistar rats’ liver. Furthermore, PB induced DNA-methyltransferases (DNMTs) activity was also demonstrated; being the enzymes that catalyze methyl group transfer to cytosine in CpG dinucleotides. Objective. Since DNA methylation is involved in regulating gene transcription and that DNMT1 is implicated in regulating DNA methylation, this study assessed whether PB-induced hypermethylation of the p53 promoter region was associated with an altered expression of p53 and Dnmt1 genes. Material and methods. Male Wistar rats received PB in three daily oral doses (at 24-h intervals) of 92,8 mg/kg b.w. x day-1. Levels of mRNA for p53 and Dnmt1 and levels of relevant proteins were respectively examined by Real-Time PCR and Western blot analysis. Results. Gene expression analysis revealed that exposure of Wistar rats to PB caused statistically significant alternations in the expression of tested genes. We found that both mRNA and protein expression of p53 was down-regulated, whereas expression of Dnmt1 (both mRNA and protein) was up-regulated after PB treatment. Conclusions. Suppression of p53 mRNA and protein expression, which is probably a result of epigenetic changes, (in particular aberrant p53 promoter hypermethylation), can be associated with tumour promoting activity of phenobarbital.
Wprowadzenie. Nasze wcześniejsze badania wykazały, że krótkoterminowe narażenie szczurów Wistar na fenobarbital (PB) stymulowało metylację cytozyny w badanych sekwencjach rejonu promotorowego genu p53. Ponadto stwierdzono wzrost aktywności metylotransferaz DNA (DNMT), enzymów które katalizują przenoszenie grupy metylowej do cytozyny w dinukleotydach CpG. Cel badań. Z uwagi że metylacja DNA pełni istotną rolę w ekspresji genów, a DNMT1 uczestniczy w regulacji metylacji DNA, w prezentowanych badaniach oceniano czy indukowana PB hipermetylacja rejonu promotorowego genu p53 była związana ze zmianami ekspresji genów p53 i Dnmt1. Materiał i metody. Samce szczurów szczepu Wistar otrzymywały PB w dawce 92,8 mg/kg m.c. x dzień-1, 3-krotnie w odstępach dobowych. Analizę poziomu transkryptów i białek badanych genów przeprowadzano odpowiednio metodą Real- -Time PCR i Western blot. Wyniki. W wyniku oddziaływania PB wykazano obniżoną ekspresję genu p53 i wzrost ekspresji metylotranserazy 1 (DNMT1). Wnioski. Supresja ekspresji p53 (na poziomie mRNA i białka) będąca prawdopodobnie wynikiem zmian epigenetycznych, w szczególności hipermetylacji jego rejonu promotorowego może być związana z promocyjną aktywnością fenobarbitalu.

Źródło:

Roczniki Państwowego Zakładu Higieny; 2014, 65, 3
0035-7715

Pojawia się w:

Roczniki Państwowego Zakładu Higieny

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:

Novel isoforms of transcript of the EDA gene confirm X-linked inheritance of anhidrotic ectodermal dysplasia

Autorzy:

Kobielak, K
Kobielak, A.
Trzeciak, W.H.

Powiązania:

https://bibliotekanauki.pl/articles/2043606.pdf

Data publikacji:

1999

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

dysplasia
inheritance
anhidrotic ectodermal dysplasia
Christ-Siemens-Touraine syndrome
Tabby gene
EDA gene
gene transcript

Źródło:

Journal of Applied Genetics; 1999, 40, 4; 355-364
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:

The influence of LDHA gene polymorphism on relative level of its expression in racing pigeons
Polimorfizm w genie LDHA i jego wpływ na względny poziom ekspresji u gołębi pocztowych

Autorzy:

Jędrzejczak-Silicka, M.
Yu, Y.-H.
Cheng, Y.-H.
Dybus, A.

Powiązania:

https://bibliotekanauki.pl/articles/2606361.pdf

Data publikacji:

2018

Wydawca:

Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie

Tematy:

gene polymorphism
gene expression
pigeon
real-time polymerase chain reaction

Źródło:

Acta Scientiarum Polonorum. Zootechnica; 2018, 17, 3; 9-15
1644-0714

Pojawia się w:

Acta Scientiarum Polonorum. Zootechnica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:

Variability in sequences of mitochondrial cox1 and nadh1 genes in Toxocara canis, Toxocara cati, and Toxascaris leonina (Nematoda: Toxocaridae) from different hosts

Autorzy:

Fogt-Wyrwas, R.
Jarosz, W.
Rzad, I.
Pilarczyk, B.
Mizgajska-Wiktor, H.

Powiązania:

https://bibliotekanauki.pl/articles/6230.pdf

Data publikacji:

2016

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

variability
mitochondrial gene
cox1 gene
nadh1 gene
Toxocara canis
Toxocara cati
Toxascaris leonina
Nematoda
Toxocaridae
host

Źródło:

Annals of Parasitology; 2016, 62, Suppl.
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:

Analysis of occurrence of virulence genes among Yersinia enterocolitica isolates belonging to different biotypes and serotypes

Autorzy:

Kot, B
Piechota, M.
Jakubczak, A.

Powiązania:

https://bibliotekanauki.pl/articles/32221.pdf

Data publikacji:

2010

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

virulence gene
occurrence
Yersinia enterocolitica
isolate
biotype
serotype
polymerase chain reaction
ystB gene
myfA gene
man
pig
isolation

Opis:

The 150 Y. enterocolitica strains isolated from humans and from pigs belonged to biotypes 4 (68.7%), 1A (18.7%) and 2 (4%), or were biochemically untypeable (8.6%). Biotype 4 was comprised of Y. enterocolitica strains representing serotype 0:3, within biotype 1A the strains either belonged to serotypes 0:5 and 0:6 or were untypeable, and biotype 2 was represented by the strains of serotype 0:9. The strains which were biochemically untypeable belonged to serotypes 0:5, 0:6 and 0:3. Among the strains tested there also were those of an unidentified biotype and serotype. Nearly all the strains of biotype 1A represented genotype ystB+myfA+, and few belonged to genotype ystB+. The presence of the ystB gene in the strains of biotype 1A and only occasional occurrence of the gene in the other biotypes makes ystB a distinguishing marker of biotype 1A. The strains of genotype ystA+ail+myfA+yadA+ predominated in biotype 4 (serotype 0:3). The strains of biotype 2 (serotype 0:9) represented genotype ystA+ail+myfA+, and the plasmid yadA gene was detected in some of them. Within the group of biochemically untypeable strains ystB- and myfA-specific PCR products were mainly obtained. The genotypes determined for the tested biotypes and serotypes of Y. enterocolitica, based upon the selected genes of virulence, can be applied as distinguishing markers and indicators of the potential virulence of Y. enterocolitica strains, excluding bioserotyping.

Źródło:

Polish Journal of Veterinary Sciences; 2010, 13, 1; 13-19
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:

Combined delivery of an antiangiogenic protein (angiostatin) and an immunomodulatory gene (interleukin-12) in the treatment of murine cancer.

Autorzy:

Wilczyńska, Urszula
Kucharska, Anna
Szary, Jarosław
Szala, Stanisław

Powiązania:

https://bibliotekanauki.pl/articles/1044050.pdf

Data publikacji:

2001

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

angiogenesis
IL-12 gene
tumor gene therapy
angiostatin

Opis:

We investigated the feasibility of a novel therapeutic approach to treat neoplastic diseases in mice. This novel strategy consists in delivering a protein (angiostatin) with strong antiangiogenic properties, followed by administration of the interleukin 12 gene that is strongly immunomodulatory and has also some antiangiogenic effects. When angiostatin-mediated antiangiogenic therapy was used in combination with intratumor delivery of the IL-12 gene (a strategy much safer than IL-12 protein administration), this produced a synergistic therapeutic effect.

Źródło:

Acta Biochimica Polonica; 2001, 48, 4; 1077-1084
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 11.

Tytuł:

Direct transfer of IL-12 gene into growing Renca tumors.

Autorzy:

Budryk, Magdalena
Wilczyńska, Urszula
Szary, Jarosław
Szala, Stanisław

Powiązania:

https://bibliotekanauki.pl/articles/1044365.pdf

Data publikacji:

2000

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

IL-12 gene
tumor gene therapy
naked DNA

Opis:

We investigated the feasibility of transferring naked plasmid DNA containing a therapeutic gene (IL-12) into mice harboring growing Renca tumors. We found that naked DNA transferred into growing Renca and B16(F10) tumors gives higher expression level of reporter gene than complexes of DNA with DDAB/ DOPE or DC-Chol/DOPE. Transfer of naked DNA carrying the IL-12 gene into growing Renca tumors causes a distinct therapeutic effect that depends on the time span between inoculation of mice with cancer cells and the beginning of the therapy. Therapy started on day 3 resulted in total cure (100%) of mice.

Źródło:

Acta Biochimica Polonica; 2000, 47, 2; 385-391
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:

Is there any mystery of ORPHANs?

Autorzy:

Cebrat, S
Dudek, M
Mackiewicz, P

Powiązania:

https://bibliotekanauki.pl/articles/2046624.pdf

Data publikacji:

1997

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

yeast
gene finding
DNA asymmetry
orphan
gene number
genome
Saccharomyces cerevisiae

Opis:

We have analysed the coding capacity of ORFs longer than 100 codons found in the yeast genome. Comparing the parameters describing the DNA asymmetry in the set of known genes and the set of all ORFs>100 codons we have found that there are about 4700 coding ORFs in the yeast genome. Since for more than 2300 ORFs recognisable functions have been already found and for about 2000 ORFs homology to known genes has been identified - only about 400 ORFs can be considered as orphans - ORFs without any known function or homology. This finding means that there is no mystery of orphans - a paradox showing that the fraction of orphans has been growing with the growing number of genes with known functions in the yeast genome.

Źródło:

Journal of Applied Genetics; 1997, 38, 4; 365-372
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 13.

Tytuł:

The association between ALR2 -106C > T gene polymorphisms and diabetic retinopathy susceptibility in diabetes mellitus patient: a systematic review and meta-analysis

Autorzy:

Putri, Indah Sagitaisna
Rezkita, Bastomy Eka
Irving, Steven
Azmiardi, Akhmad

Powiązania:

https://bibliotekanauki.pl/articles/4175390.pdf

Data publikacji:

2023-03-27

Wydawca:

Medical Education

Tematy:

ALR2 gene
diabetic retinopathy
diabetes mellitus
gene polymorphism
polyol pathway

Opis:

Aldose reductase gene polymorphisms has been indicated to be associated with diabetic retinopathy (DR). The research data were from PubMed and EMBASE. We identified -106C > T single nucleotide polymorphism (SNP). Pool odds ratio (OR) with 95% CI were calculated. Nine studies were included. ALR2 106C > T gene polymorphisms was associated with the increased risk of DR in T1DM (C vs. T, OR = 2.07, p = 0.001; CC vs. CT + TT, OR = 2.56, p = 0.005). T allele and TT genotype were associated with decreased risk of DR in T1DM (OR = 0.48, p = 0.0001 and OR = 0.12, p = 0.0005). In conclusion, C allele and CC genotype may be a risk factor, while T allele and TT genotype may serve as protective factor for DR in T1DM patient.

Źródło:

OphthaTherapy; 2023, 10, 1; 12-21
2353-7175
2543-9987

Pojawia się w:

OphthaTherapy

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 14.

Tytuł:

Calcium phosphate nanoparticles for gene transfer and silencing - a 2D and 3D cell culture model study

Autorzy:

Bialas, N.
Sanchez, L. R.
Sokolova, V.
Epple, M.

Powiązania:

https://bibliotekanauki.pl/articles/285631.pdf

Data publikacji:

2017

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

nanoparticles
gene transfer
silencing

Źródło:

Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 34
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:

ERF022 controls somatic embryogenesis in Arabidopsis via ethylene-related mechanism

Autorzy:

Nowak, K.
Gaj, M.D.

Powiązania:

https://bibliotekanauki.pl/articles/80300.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

conference
gene encoding
transcription factor
somatic embryogenesis
ERF022 gene
Arabidopsis
expression pattern
tf gene
plant stress
ethylene biosynthesis

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 16.

Tytuł:

Genetic study of familial cases of Alzheimers disease.

Autorzy:

Kowalska, Anna
Pruchnik-Wolińska, Danuta
Florczak, Jolanta
Modestowicz, Renata
Szczech, Józef
Kozubski, Wojciech
Rossa, Grzegorz
Wender, Mieczysław

Powiązania:

https://bibliotekanauki.pl/articles/1043353.pdf

Data publikacji:

2004

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

neurodegeneration
dementia
presenilin 1 gene
amyloid precursor protein gene
Alzheimer's disease
mutation
presenilin 2 gene

Opis:

A small number (1-5%) of Alzheimer's disease (AD) cases associated with the early-onset form of the disease (EOAD) appears to be transmitted as a pure genetic, autosomal dominant trait. To date, three genes responsible for familial EOAD have been identified in the human genome: amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2). Mutations in these genes account for a significant fraction (18 to 50%) of familial cases of early onset AD. The mutations affect APP processing causing increased production of the toxic Aβ42 peptide. According to the "amyloid cascade hypothesis", aggregation of the Aβ42 peptide in brain is a primary event in AD pathogenesis. In our study of twenty AD patients with a positive family history of dementia, 15% (3 of 20) of the cases could be explained by coding sequence mutations in the PS1 gene. Although a frequency of PS1 mutations is less than 2% in the whole population of AD patients, their detection has a significant diagnostic value for both genetic counseling and treatment in families with AD.

Źródło:

Acta Biochimica Polonica; 2004, 51, 1; 245-242
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 17.

Tytuł:

Novel regulators of photosynthesis

Autorzy:

Leister, D.

Powiązania:

https://bibliotekanauki.pl/articles/80943.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

conference
photosynthesis
chloroplast
gene expression
nuclear protein
nuclear gene
protein
thylakoid protein

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 18.

Tytuł:

Structural and functional genomics in domestic animals: the way to understand the phenotype

Autorzy:

Schwerin, M

Powiązania:

https://bibliotekanauki.pl/articles/2042006.pdf

Data publikacji:

2001

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

genome analysis
gene expression
candidate gene
farm animal
phenotype
livestock
domestic animal

Źródło:

Journal of Applied Genetics; 2001, 42, 3; 293-308
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 19.

Tytuł:

The 5 regulatory sequence of the PMP22 in the patients with Charcot-Marie-Tooth disease

Autorzy:

Sinkiewicz-Darol, Elena
Kabzińska, Dagmara
Moszyńska, Izabela
Kochański, Andrzej

Powiązania:

https://bibliotekanauki.pl/articles/1040387.pdf

Data publikacji:

2010

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

gene dosage effect
Charcot-Marie-Tooth disease
PMP22 gene

Opis:

Little is known about the molecular background of clinical variability of Charcot-Marie-Tooth type 1A (CMT1A) disease and hereditary neuropathy with liability to pressure palsies (HNPP). The CMT1A and HNPP disorders result from duplication and deletion of the PMP22 gene respectively. In a series of studies performed on affected animal transgenic models of CMT1A disease, expression of the PMP22 gene (gene dosage) was shown to correlete with severity of CMT course (gene dosage effect). In this study we hypothesized that single nucleotide polymorphisms (SNPs) located within the 5' regulatory sequence of PMP22 gene may be responsible for the CMT1A/HNPP clinical variability. We have sequenced the PMP22 5' upstream regulatory sequence in a group of 45 CMT1A/HNPP patients harboring the PMP22 duplication (37) /deletion (8). We have identified five SNPs in the regulatory sequence of the PMP22 gene. Three of them i.e. -819C>T, -4785G>T, -4800C>T were detected both in the patients and in the control group. Thus, their pathogenic role in the regulation of the expression of the PMP22 gene seems not to be significant. Two SNPs i.e. -4210T>C and -4759T>A were found only in the CMT patients. Their role in the regulation of the PMP22 gene expression can not be excluded. Additionally we have detected the Thr118Met variant in exon 4 of the PMP22 gene, which was previously reported by other authors, in one patient. We conclude that the 5' regulatory sequence of the PMP22 gene is conserved at the nucleotiode level, however rarely occurring SNPs variant in the PMP22 regulatory sequence may be associated with the gene dosage effect.

Źródło:

Acta Biochimica Polonica; 2010, 57, 3; 373-377
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 20.

Tytuł:

Ensemble of data mining methods for gene ranking

Autorzy:

Wiliński, A.
Osowski, S.

Powiązania:

https://bibliotekanauki.pl/articles/201570.pdf

Data publikacji:

2012

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

gene expression array
feature selection
gene ranking methods
classification
SVM

Opis:

The paper presents the ensemble of data mining methods for discovering the most important genes and gene sequences generated by the gene expression arrays, responsible for the recognition of a particular type of cancer. The analyzed methods include the correlation of the feature with a class, application of the statistical hypotheses, the Fisher measure of discrimination and application of the linear Support Vector Machine for characterization of the discrimination ability of the features. In the first step of ranking we apply each method individually, choosing the genes most often selected in the cross validation of the available data set. In the next step we combine the results of different selection methods together and once again choose the genes most frequently appearing in the selected sets. On the basis of this we form the final ranking of the genes. The most important genes form the input information delivered to the Support Vector Machine (SVM) classifier, responsible for the final recognition of tumor from non-tumor data. Different forms of checking the correctness of the proposed ranking procedure have been applied. The first one is relied on mapping the distribution of selected genes on the two-coordinate system formed by two most important principal components of the PCA transformation and applying the cluster quality measures. The other one depicts the results in the graphical form by presenting the gene expressions in the form of pixel intensity for the available data. The final confirmation of the quality of the proposed ranking method are the classification results of recognition of the cancer cases from the non-cancer (normal) ones, performed using the Gaussian kernel SVM. The results of selection of the most significant genes used by the SVM for recognition of the prostate cancer cases from normal cases have confirmed a good accuracy of results. The presented methodology is of potential use for practical application in bioinformatics.

Źródło:

Bulletin of the Polish Academy of Sciences. Technical Sciences; 2012, 60, 3; 461-470
0239-7528

Pojawia się w:

Bulletin of the Polish Academy of Sciences. Technical Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 21.

Tytuł:

CRH gene polymorphism in relation to milk production traits in cattle
Polimorfizm w genie CRH w powiązaniu z cechami użytkowości mlecznej bydła

Autorzy:

Kulig, H.
Kowalewska-Luczak, I.
Szydlowska, J.

Powiązania:

https://bibliotekanauki.pl/articles/44889.pdf

Data publikacji:

2011

Wydawca:

Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie

Tematy:

CRH gene
gene polymorphism
milk production trait
cattle
dairy cattle

Opis:

The aim of this study was to estimate the relations between the CRH-A145G polymorphism and milk production traits (yields of milk, protein, and fat, as well as protein and fat content) in 176 Jersey cows. The genotype and allele frequencies were estimated and they were as follows: AG – 0.31; GG – 0.69; A – 0.16; G – 0.84. Statistical analysis revealed that studied polymorphism significantly affected the fat yield, fat content (P≤0.05) and protein content in milk (P≤0.05). The results indicate that selection for the CRH-A145G AG animals might contribute to increase the value of these traits in Jersey cattle. However, further studies are necessary to verify the results of our study.
Celem badań było oszacowanie zależności między polimorfizmem CRH-A145G a cechami użytkowości mlecznej (wydajnością mleka, tłuszczu i białka oraz zawartością tłuszczu i białka w mleku) bydła. Badania przeprowadzono na stadzie 176 krów rasy jersey. Oszacowano częstość występowania genotypów i alleli, które wynosiły: AA – 0,00; AG – 0,31; GG – 0,69; A – 0,16; G – 0,84.Analiza statystyczna wykazała, że badany polimorfizm wpływał istotnie na wydajność tłuszczu i zawartość tłuszczu (P≤0,01) oraz na zawartość białka w mleku (P≤0,05).Wyniki wskazują, że uwzględnienie w selekcji osobników z genotypem CRH-A145G AG mogłoby przyczynić się do zwiększenia wartości powyższych cech u bydła rasy jersey. Wymagane jest jednak kontynuowanie badań aby móc zweryfikować uzyskane wyniki.

Źródło:

Acta Scientiarum Polonorum. Zootechnica; 2011, 10, 1
1644-0714

Pojawia się w:

Acta Scientiarum Polonorum. Zootechnica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 22.

Tytuł:

Properties of a Singular Value Decomposition Based Dynamical Model of Gene Expression Data

Autorzy:

Simek, K.

Powiązania:

https://bibliotekanauki.pl/articles/908156.pdf

Data publikacji:

2003

Wydawca:

Uniwersytet Zielonogórski. Oficyna Wydawnicza

Tematy:

informatyka
multiple gene expression
singular value decomposition
dynamical model of gene expression data

Opis:

Recently, data on multiple gene expression at sequential time points were analyzed using the Singular Value Decomposition (SVD) as a means to capture dominant trends, called characteristic modes, followed by the fitting of a linear discrete-time dynamical system in which the expression values at a given time point are linear combinations of the values at a previous time point. We attempt to address several aspects of the method. To obtain the model, we formulate a nonlinear optimization problem and present how to solve it numerically using the standard MATLAB procedures. We use freely available data to test the approach. We discuss the possible consequences of data regularization, called sometimes "polishing", on the outcome of the analysis, especially when the model is to be used for prediction purposes. Then, we investigate the sensitivity of the method to missing measurements and its abilities to reconstruct the missing data. Summarizing, we point out that approximation of multiple gene expression data preceded by SVD provides some insight into the dynamics, but may also lead to unexpected difficulties, like overfitting problems.

Źródło:

International Journal of Applied Mathematics and Computer Science; 2003, 13, 3; 337-345
1641-876X
2083-8492

Pojawia się w:

International Journal of Applied Mathematics and Computer Science

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 23.

Tytuł:

Involvement of plastid, mitochondrial and nuclear genomes in plant-to-plant horizontal gene transfer

Autorzy:

Sanchez-Puerta, M.V.

Powiązania:

https://bibliotekanauki.pl/articles/57778.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Botaniczne

Tematy:

angiosperm
plastid
mitochondrial genome
nuclear genome
genome
horizontal gene transfer
gene conversion
parasite

Opis:

This review focuses on plant-to-plant horizontal gene transfer (HGT) involving the three DNA-containing cellular compartments. It highlights the great incidence of HGT in the mitochondrial genome (mtDNA) of angiosperms, the increasing number of examples in plant nuclear genomes, and the lack of any convincing evidence for HGT in the well-studied plastid genome of land plants. Most of the foreign mitochondrial genes are non-functional, generally found as pseudogenes in the recipient plant mtDNA that maintains its functional native genes. The few exceptions involve chimeric HGT, in which foreign and native copies recombine leading to a functional and single copy of the gene. Maintenance of foreign genes in plant mitochondria is probably the result of genetic drift, but a possible evolutionary advantage may be conferred through the generation of genetic diversity by gene conversion between native and foreign copies. Conversely, a few cases of nuclear HGT in plants involve functional transfers of novel genes that resulted in adaptive evolution. Direct cell-to-cell contact between plants (e.g. host-parasite relationships or natural grafting) facilitate the exchange of genetic material, in which HGT has been reported for both nuclear and mitochondrial genomes, and in the form of genomic DNA, instead of RNA. A thorough review of the literature indicates that HGT in mitochondrial and nuclear genomes of angiosperms is much more frequent than previously expected and that the evolutionary impact and mechanisms underlying plant-to-plant HGT remain to be uncovered.

Źródło:

Acta Societatis Botanicorum Poloniae; 2014, 83, 4
0001-6977
2083-9480

Pojawia się w:

Acta Societatis Botanicorum Poloniae

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 24.

Tytuł:

Der Geist und sein Denken. Zur Rezeption der platonischen megista-gene Lehre bei Plotin und Proklos
The Spirit and Its Thinking. On the Recepcion of Plato’s megista gēnē Doctrine in Plotinus and Proclus

Autorzy:

Gögelein, Simon

Powiązania:

https://bibliotekanauki.pl/articles/938385.pdf

Data publikacji:

2014

Wydawca:

Uniwersytet im. Adama Mickiewicza w Poznaniu

Tematy:

Plato
megista gēnē
Plotinus
Proclus

Opis:

This article is primarily concerned with Platoʼs later dialogue, the Sophist, and the reception of the megista-gēnē-dialectic in Neoplatonism (especially Plotinus and Proclus). The present paper offers a historical comparative study that consists of three parts. The first one gives a short summary concerning Platoʼs request regarding the concept of inverse and complex Ideas. The second one examines Plotinus’ conception of the νοῦς (Enn. VI 2, 7–8), in which the megista gēnē στάσις, κίνησις, ὄν, ταὐτόν and ἕτερον constitute the realm of the intellect. While the third and final part of the article investigates Proclusʼ extrapolation of the Platonic dialectic, it focuses on selected passages from the Commentary on the Parmenides. The paper concludes with a summary of the results.

Źródło:

Peitho. Examina Antiqua; 2014, 5, 1; 139-162
2082-7539

Pojawia się w:

Peitho. Examina Antiqua

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 25.

Tytuł:

Expression of genes encoding mitochondrial proteins can distinguish nonalcoholic steatosis from steatohepatitis

Autorzy:

Bragoszewski, Piotr
Habior, Andrzej
Walewska-Zielecka, Bozena
Ostrowski, Jerzy

Powiązania:

https://bibliotekanauki.pl/articles/1041083.pdf

Data publikacji:

2007

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

NAFLD
gene expression
NASH
mitochondria

Opis:

In patients without substantial alcohol use, triglyceride accumulation in the liver can lead to nonalcoholic fatty liver disease (NAFLD) that may progress to nonalcoholic steatohepatitis (NASH). The differential diagnosis between NAFLD and NASH can be accomplished only by morphological examination. Although the relationship between mitochondrial dysfunction and the progression of liver pathologic changes has been described, the exact mechanisms initiating primary liver steatosis and its progression to NASH are unknown. We selected 16 genes encoding mitochondrial proteins which expression was compared by quantitative RT-PCR in liver tissue samples taken from patients with NAFLD and NASH. We found that 6 of the 16 examined genes were differentially expressed in NAFLD versus NASH patients. The expression of hepatic HK1, UCP2, ME2, and ME3 appeared to be higher in NASH than in NAFLD patients, whereas HMGCS2 and hnRNPK expression was lower in NASH patients. Although the severity of liver morphological injury in the spectrum of NAFLD-NASH may be defined at the molecular level, expression of these selected 6 genes cannot be used as a molecular marker aiding histological examination. Moreover, it is still unclear whether these differences in hepatic gene expression profiles truly reflect the progression of morphological abnormalities or rather indicate various metabolic and hormonal states in patients with different degrees of fatty liver disease.

Źródło:

Acta Biochimica Polonica; 2007, 54, 2; 341-348
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 26.

Tytuł:

Construction of a bicistronic proangiogenic expression vector and its application in experimental angiogenesis in vivo.

Autorzy:

Małecki;, Maciej
Przybyszewska, Małgorzata
Janik, Przemysław

Powiązania:

https://bibliotekanauki.pl/articles/1043468.pdf

Data publikacji:

2003

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

angiogenesis
gene therapy
bicistronic vectors

Opis:

Manipulation of angiogenesis in vivo is an example of successful gene therapy strategies. Overexpression of angiogenic genes like VEGF, FGF or PDGF causes new vessel formation and improves the clinical state of patients. Gene therapy is a very promising procedure but requires large amounts of pharmaceutical-grade plasmid DNA. In this regard we have constructed a bicistronic plasmid DNA vector encoding two proangiogenic factors, VEGF165 and FGF-2. The construct (pVIF) contains the internal ribosome entry site (IRES) of the encephalomyocarditis virus (ECMV) which permits both genes to be translated from a single bicistronic mRNA. The IRES sequence allows for a high efficiency of gene expression in vivo. The pVIF vector was characterized in vitro and in vivo. In vivo angiogenesis studies showed that the bicistronic vector encoding two proangiogenic factors induces the formation of new vessels significantly more than pVEGF165 or pFGF-2 alone. In our opinion the combined proangiogenic approach with VEGF165 and FGF-2 is more powerful and efficient than single gene therapy. We also postulate that IRES sequence can serve as a useful device improving efficiency of gene therapy.

Źródło:

Acta Biochimica Polonica; 2003, 50, 3; 875-882
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 27.

Tytuł:

Genetic predisposition to breast and/or ovarian cancer – focus on the candidate BARD1 gene

Autorzy:

Klonowska, K.
Ratajska, M.
Wojciechowska, M.
Kozlowski, P.

Powiązania:

https://bibliotekanauki.pl/articles/80894.pdf

Data publikacji:

2014

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

breast cancer
ovarian cancer
genetic predisposition
BRCA1 gene
structure
function
BARD1 gene

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2014, 95, 3
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 28.

Tytuł:

Telomeraza – struktura i funkcja oraz regulacja ekspresji genu
Telomerase – structure, function and the regulation of gene expression

Autorzy:

Bryś, Magdalena
Laskowska, Magdalena
Forma, Ewa
Krześlak, Anna

Powiązania:

https://bibliotekanauki.pl/articles/1032770.pdf

Data publikacji:

2012

Wydawca:

Łódzkie Towarzystwo Naukowe

Tematy:

telomeraza
gen
białko
ekspresja genu
czynniki
transkrypcyjne
telomerase
gene
protein
gene expression
transcription factors

Opis:

A telomere is a fragment localized at the end of chromosome which protects the chromosome from damage during replication. Telomeres are also factors that control number of cell divisions and are thought to be a suppressors of carcinogenesis since limited, strictly determined number of cell divisions protects from accumulation of mutations in cell. It is assumed that presence of 4-6 mutation in genetic material is a carcinogenic factor and after about 60-70 divisions, the cell enter the resting phase. Telomerase is an enzyme which adds DNA sequence to the 3’ end of DNA and extends the telomere region. This protein is a DNA polymerase dependent on RNA, which syntheses telomere by reverse transcription. The unique characteristics of telomerase is that RNA matrix for DNA synthesis is an integral component of this enzyme. Telomerase is present in intensively dividing cells and its activity is decreasing with age. In normal cells usually activity of telomerase is undetectable but in cancer cells activity of this enzyme is high. The aim of this work is to present the structure of telomeres and the role of proteins involved in maintaining the structure. In details, the structure and function of the telomerase gene/protein is described, including the regulation of gene expression at the transcriptional level. The involvement of telomerase in the neoplastic transformation has been also characterized.
Telomer jest to fragment chromosomu zlokalizowany na jego końcu, który zabezpiecza go przed uszkodzeniem podczas kopiowania. Telomery są także czynnikami kontrolującymi liczbę podziałów komórkowych i dlatego uważane są za supresory transformacji nowotworowej, ponieważ ograniczona, ściśle kontrolowana liczba podziałów zapobiega ewentualnemu kumulowaniu się mutacji w komórce. Przyjęto, że obecność 4-6 mutacji w materiale genetycznym jest czynnikiem karcynogennym, a po granicznej liczbie podziałów (około 60-70) komórka wchodzi w fazę spoczynku M1. Enzymem, którego zadaniem jest dobudowanie 3'-końcowego odcinka nici DNA i tym samym wydłużanie sekwencji telomerowych jest enzym telomeraza. Białko to jest polimerazą DNA zależną od RNA, która syntetyzuje telomery na zasadzie odwrotnej transkrypcji. Unikalną cechą telomerazy jest to, że jej integralnym składnikiem jest matryca RNA służąca do syntezy DNA. Telomeraza występuje w intensywnie dzielących się komórkach, a jej aktywność zmniejsza się wraz z wiekiem. W komórkach prawidłowych zwykle nie stwierdza się aktywności telomerazy, natomiast w nowotworowych aktywność tego enzymu zwykle jest podwyższona. W pracy omówiono strukturę sekwencji telomerowych oraz udział białek zaangażowanych w jej utrzymanie. Szczegółowo przedstawiono także strukturę i funkcję genu/białka telomerazy, z uwzględnieniem regulacji ekspresji genu na poziomie transkrypcji. Scharakteryzowano ponadto udział telomerazy w procesach transformacji nowotworowej.

Źródło:

Folia Medica Lodziensia; 2012, 39, 2; 293-326
0071-6731

Pojawia się w:

Folia Medica Lodziensia

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 29.

Tytuł:

Association between RBMS1 gene rs7593730 and BCAR1 gene rs7202877 and Type 2 diabetes mellitus in the Chinese Han population

Autorzy:

Kazakova, Elena
Chen, Meijun
Jamaspishvili, Esma
Lin, Zhang
Yu, Jingling
Sun, Lulu
Qiao, Hong

Powiązania:

https://bibliotekanauki.pl/articles/1038363.pdf

Data publikacji:

2018

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

type 2 diabetes mellitus
RBMS1 gene
BCAR1 gene
single nucleotide polymorphisms
SNPscan

Opis:

Two recent studies found that RBMS1 gene rs7593730 and BCAR1 gene rs7202877 are related to type 2 diabetes. However, the association of these loci with type 2 diabetes mellitus (T2DM) has not been examined in Chinese. We performed a replication study to investigate the association of the 2 susceptibility loci with T2DM in the Chinese population. We genotyped 1961 Chinese participants (991 with T2DM and 970 controls) for each of the 2 single nucleotide polymorphisms (SNPs) rs7593730 in RBMS1 and rs7202877 near BCAR1 using SNPscan and examined their association with T2DM using logistic regression analysis. We also analyzed the correlation of the SNP alleles and clinical phenotypes. In additive model, genotype association analysis of BCAR1 rs7202877 loci revealed that the homozygous of rs7202877 GG carriers had significantly decreased T2DM risk compared to homozygous carriers of TT (P=0.038, OR 0.44, 95% CI 0.20-0.96). In the recessive model, the GG genotype GG had significantly decreased T2DM risk compared to GT+TT (P=0.043, OR 0.67, 95% CI 0.46-0.99). Allele G was statistically significantly correlated with TC (mmol/L) (P=0.036) and LDL-C (mmol/L) (P=0.007). As for rs7593730, the carriers of CT and TT genotype had significantly decreased T2DM risk compared to the carriers of CC genotype (CT: CC P=0.038, OR 0.71, 95% CI 0.51-0.98; TT: CC P=0.010, OR 0.32, 95% CI 0.13-0.76). In a dominant model, TT+CT: CC (P=0.013, OR 0.673, 95% CI 0.49-0.92) and in a recessive model, TT: CT+CC (P=0.019, OR 0.59, 95% CI 0.39-0.92). The T allele carriers had significantly decreased T2DM risk compared to the carriers of C (P=0.002, OR 0.65, 95% CI 0.50-0.86). Allele T was statistically correlated with FINS (P=0.010). In conclusion, our study showed that RBMS1 gene rs7593730 and BCAR1 gene rs7202877 were significantly associated with type 2 diabetes in the Chinese population.

Źródło:

Acta Biochimica Polonica; 2018, 65, 3; 377-382
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 30.

Tytuł:

The uselessness of cytochrome oxydase gene analysis for genetic identification of selected Gobiidae species from some European countries

Autorzy:

Kiełpińska, Jolanta
Czerniejewski, Przemysław
Adamkowska, Natalia
Uzunova, Eliza

Powiązania:

https://bibliotekanauki.pl/articles/2203561.pdf

Data publikacji:

2022

Wydawca:

Instytut Technologiczno-Przyrodniczy

Tematy:

cytochrome oxidase subunit 1 gene
COI gene
Gobiidae
invasive species
native species
mt DNA

Opis:

The family Gobiidae is the largest teleost family, consisting of more than 2,000 species in more than 200 genera. They have adapted to a wide range of habitats, inhabiting mostly marine and brackish waters. Recently invasive Ponto-Caspian gobies have caused significant changes to the structure of fish assemblage throughout the European waters. The aim of the study was to verify the possibility of identifying three species of the genus Gobiidae based on the analysis of the mitochondrial region of the cytochrome oxidase subunit 1 (COI) gene. 339 samples originated from seven countries and 17 different sites were investigated. Qualitative and quantitative assessment of the extracted DNA was conducted by measuring light absorbance and electrophoretic separation. Approximately 650-bp (base pairs) fragments were amplified from the 5' region of the mitochondrial COI with the PCR (polymerase chain reaction) reaction. Sequences of 652 bp were obtained and compared with reference sequences in the National Center for Biotechnology Information (NCBI). Based on the sequence analysis, we determined that in the analysed geographical regions, the goby preliminary identified morphologically as the round goby was represented by three species: round goby (Neogobius melanostomus), tubenose goby (Proterorhinus marmoratus), and monkey goby (Neogobius fluviatilis). The latter two are newly reported for their new habitats. Genetic characterisation of such populations offers the opportunity to assess their genetic stability, which provides agencies managing the aquatic environment in EU countries with a tool for revising the legislation, including regulations relevant for updating the status of native and invasive species in European waters.

Źródło:

Journal of Water and Land Development; 2022, Special Issue; 8--14
1429-7426
2083-4535

Pojawia się w:

Journal of Water and Land Development

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 31.

Tytuł:

Effect of bamboo vinegar powder on the expression of the immune-related genes MyD88 and CD14 in weaning piglets

Autorzy:

Qin, W.Y.
Gan, L.N.
Dong, L.
Yu, L.H.
Wu, S.L.
Bao, W.B.

Powiązania:

https://bibliotekanauki.pl/articles/2087674.pdf

Data publikacji:

2018

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

bamboo vinegar powder
pig
antibiotics
MyD88 gene
CD14 gene

Źródło:

Polish Journal of Veterinary Sciences; 2018, 21, 3; 525-532
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 32.

Tytuł:

The role of cell adhesion molecule in cancer progression and its application in cancer therapy.

Autorzy:

Okegawa, Takatsugu
Pong, Rey-Chen
Li, Yingming
Hsieh, Jer-Tsong

Powiązania:

https://bibliotekanauki.pl/articles/1043281.pdf

Data publikacji:

2004

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

cancer gene therapy
gene
cell adhesion molecules
tumor progression
tumor suppressor

Opis:

Multiple and diverse cell adhesion molecules take part in intercellular and cell-extracellular matrix interactions of cancer. Cancer progression is a multi-step process in which some adhesion molecules play a pivotal role in the development of recurrent, invasive, and distant metastasis. A growing body of evidence indicates that alterations in the adhesion properties of neoplastic cells play a pivotal role in the development and progression of cancer. Loss of intercellular adhesion and the desquamation of cells from the underlying lamina propria allows malignant cells to escape from their site of origin, degrade the extracellular matrix, acquire a more motile and invasion phenotype, and finally, invade and metastasize. In addition to participating in tumor invasiveness and metastasis, adhesion molecules regulate or significantly contribute to a variety of functions including signal transduction, cell growth, differentiation, site-specific gene expression, morphogenesis, immunologic function, cell motility, wound healing, and inflammation. Cell adhesion molecule (CAM), a diverse system of transmembrane glycoproteins has been identified that mediates the cell-cell and cell-extracellular matrix adhesion and also serves as the receptor for different kinds of virus. We summarize recent progress regarding the role of CAM, particularly, immunoglobulin-CAMs and cadherins in the progression of cancer and discuss the potential application of CAMs in the development of cancer therapy mainly on urogenital cancer.

Źródło:

Acta Biochimica Polonica; 2004, 51, 2; 445-457
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 33.

Tytuł:

Changes in DNA methylation in maize under herbicide stress conditions

Autorzy:

Tyczewska, A.
Gracz, J.
Szymkowiak, J.
Twardowski, T.

Powiązania:

https://bibliotekanauki.pl/articles/951318.pdf

Data publikacji:

2015

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

DNA methylation
chromatin modification
gene silencing
gene transcription
maize
herbicide stress

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 1
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 34.

Tytuł:

An analysis of PPARGC1A gene polymorphism in relation to carcass quality in PIC hybrid fatteners
Analiza polimorfizmu genu PPARGC1A w odniesieniu do cech tuszy tuczników hybrydowych PIC

Autorzy:

Polasik, D.
Glodek, A.
Rybarczyk, A.

Powiązania:

https://bibliotekanauki.pl/articles/45231.pdf

Data publikacji:

2013

Wydawca:

Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie

Tematy:

PPARGC1A gene
gene polymorphism
polymorphism
carcass quality
hybrid
fattener

Opis:

The aim of this study was to determine the association between polymorphism located in exon 8 of PPARGC1A gene (Cys430Ser) and carcass quality in pigs. Experiment was carried out on 350 PIC hybrid fatteners. Polymorphism was analyzed using PCR-RFLP method. The frequency of genotypes was as follows: AA – 0.33, AT – 0.57, TT – 0.1, however alleles: A – 0.62, T – 0.38. In the analyzed population loss of Hardy-Weinberg equilibrium was observed (P ≤ 0.01). Statistical analysis showed that only one of the evaluated traits was associated with individual PPARGC1A genotypes. Cooling loss value for pig carcasses with TT genotype was statistically significant (P ≤ 0.05) higher than observed in those with AA and AT genotypes.
Celem niniejszych badań było wykazanie zależności pomiędzy polimorfizmem zlokalizowanym w 8 eksonie genu PPARGC1A (Cys430Ser) a cechami tuszy świń. Eksperyment został przeprowadzony na 350 tucznikach hybrydowych PIC. Polimorfizm analizowano z użyciem metody PCR-RFLP. Frekwencja genotypów była następująca: AA - 0.33, AT - 0.57, TT - 0.1, natomiast alleli: A - 0.62, T - 0.38. W analizowanej populacji zaobserwowano zachwianie równowagi genetycznej Hardy’ego-Weinberga (P ≤ 0,01). Analiza statystyczna wykazała, że tylko jedna z ocenianych cech była powiązana z poszczególnymi genotypami PPARGC1A. Wartość strat chłodzenia (%) dla świń z genotypem TT była statystycznie istotnie (P ≤ 0,05) wyższa niż obserwowana u osobników z genotypami AA i AT.

Źródło:

Acta Scientiarum Polonorum. Zootechnica; 2013, 12, 4
1644-0714

Pojawia się w:

Acta Scientiarum Polonorum. Zootechnica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 35.

Tytuł:

Gene pool variation of Fragaria × ananassa (Duch.) and Fragaria vesca (L.)
Zmienność w obrębie zasobów genowych Fragaria × ananassa (Duch.) i Fragaria vesca (L.)

Autorzy:

Dziadczyk, E.
Dziadczyk, P.
Tyrka, M.

Powiązania:

https://bibliotekanauki.pl/articles/11543047.pdf

Data publikacji:

2015

Wydawca:

Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie

Tematy:

gene variant
Fragaria ananassa
Fragaria vesca
gene pool
hybrid
interspecific hybrid

Opis:

Gene pool variation of twenty varieties and breeding clones of Fragaria × ananassa, nine varieties and breeding lines of Fragaria vesca, and one new interspecific hybrid designated Fragaria × anavesca was analysed with three DNA marker systems. ISSR reactions with four primers produced 45 polymorphic markers. Similarly, RAPD analyses with three primers produced 26 markers and SSR method with three primer pairs revealed 28 different alleles. The total number of 99 polymorphic markers allowed distinguishing clearly a group of F. × ananassa genotypes from that of F. vesca genotypes with F. × anavesca in between of these two. RAPD markers proved to be more informative than ISSRs as 3 of 26 were specific to F. × ananassa only and one exclusively to F. vesca and F. × anavesca. Thus, the presumed hybrid nature of F. × anavesca was effectively confirmed by RAPD markers. Especially important was the 1100bp long PCR product of the B104 primer present in all F. vesca genotypes as well as in F. × anavesca but absent in F. × ananassa. Presence of F. vesca DNA in the hybrid F. × anavesca was additionally corroborated by the 223bp product of the UDF017 primer pair and the 185bp-long band generated with the UDF006 primer pair.
Analizowano zmienność w puli genów dwudziestu odmian i klonów hodowlanych Fragaria × ananassa, dziewięciu odmian i linii hodowlanych Fragaria vesca i nowego prawdopodobnego mieszańca międzygatunkowego nazwanego Fragaria × anavesca przy zastosowaniu trzech systemów markerów DNA. Cztery startery ISSR wygenerowały 45 markerów polimorficznych. Trzy startery RAPD dały 26 markerów, natomiast trzy startery SSR – 28 markerów polimorficznych. 99 uzyskanych markerów polimorficznych pozwoliło na jednoznaczne odróżnienie grupy genotypów należących do gatunku F. × ananassa od grupy genotypów należących do gatunku F. vesca z mieszańcem F. × anavesca sytuującym się pomiędzy nimi. Markery RAPD okazały się lepszym źródłem informacji niż ISSR, ponieważ 3 spośród 26 były specyficzne tylko dla F. × ananassa, a jeden wyłącznie dla F. vesca i F. × anavesca. W ten sposób, za pomocą markerów RAPD, potwierdzona została przypuszczalna wcześniej mieszańcowość F. × anavesca. Szczególnie istotny okazał się produkt reakcji PCR ze starterem B104 o długości 1100pz obecny we wszystkich genotypach F. vesca oraz F. × anavesca, a niewystępujący u F. × ananassa. Obecność DNA pochodzącego z F. vesca w mieszańcu F. × anavesca została dodatkowo potwierdzona poprzez produkt pary starterów UDF017 o długości 223pz i produkt pary starterów UDF006 o długości 185pz.

Źródło:

Acta Scientiarum Polonorum. Hortorum Cultus; 2015, 14, 2; 41-50
1644-0692

Pojawia się w:

Acta Scientiarum Polonorum. Hortorum Cultus

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 36.

Tytuł:

Linkage and interdependence of A2MD1 and A2ME2 alpha2-macroglobulin genes in cattle

Autorzy:

Wegrzyn, J
Skiba, E
Krzyscin, P

Powiązania:

https://bibliotekanauki.pl/articles/2047144.pdf

Data publikacji:

1997

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

antigen marker
gene
animal production
alpha2-macroglobulin
cattle
antigenic determinant
protein
marker
A2MD1 gene
A2ME2 gene

Opis:

The transmission of previously described genes A2MD1 and A2ME2 that determine antigenic markers of alpha₂-macroglobulins A₂mD1 and А₂mЕ2 in cattle was studied. The starting point for the analyses was the lack of individuals negative for both markers in the population of 3551 Black-and-White, Red-and-White, Polish Red and Simmental cattle and interbreed crosses. Controlling of these specificities by allelic genes or genes from closely linked loci was considered. To support or reject this hypothesis, the independence test 2 x 2 and analysis of segregation of A₂mD1 and А₂mЕ2 in the offsprings of all phenotypic matings found and of selected matings in which genotypes of sires were determined, were used. It was found that the observed segregation of antigenic markers in the offsprings rules out the possibility that they are determined by allelic genes. The results obtained show that markers A₂mD1 and А₂mЕ2 are controlled by the genes A2MD1 and A2ME2 from closely linked loci. Moreover it seems that only those haplotypes are transmitted in which both genes - A2MD1 and A2ME2, or one of them - A2MD1 or A2ME2, are present. No haplotypc would then be transmitted (would occur?) in which both genes are in the recessive form. recessive form.

Źródło:

Journal of Applied Genetics; 1997, 38, 2; 187-193
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 37.

Tytuł:

Cross-species hybridizations in situ of genes associated with meat production traits in the wild pig genome
Międzygatunkowe hybrydyzacje in situ genów związanych z cechami użytkowości mięsnej w genomie dzika

Autorzy:

Kozubska-Sobocinska, A.
Danielak-Czech, B.
Babicz, M.

Powiązania:

https://bibliotekanauki.pl/articles/2196829.pdf

Data publikacji:

2015

Wydawca:

Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie

Tematy:

wild pig
fluorescence in situ hybridization
cross-species hybridization
in situ hybridization
gene
meat production trait
genome
ghrelin
UCP2 gene
UCP3 gene

Źródło:

Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica; 2015, 33, 3; 31-36
0239-4243
2083-7399

Pojawia się w:

Annales Universitatis Mariae Curie-Skłodowska. Sectio EE: Zootechnica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 38.

Tytuł:

Annotating a non-model plant genome – a study on the narrow-leafed lupin

Autorzy:

Zielezinski, A.
Potarzycki, P.
Ksiazkiewicz, M.
Karlowski, W.M.

Powiązania:

https://bibliotekanauki.pl/articles/80218.pdf

Data publikacji:

2012

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

genome
plant genome
pipeline
software
narrow-leaved lupin
gene annotation system
gene sequence
DNA sequence

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2012, 93, 3
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 39.

Tytuł:

Identification of miRNAs and their potential targets in halophyte plant Thellungiella halophila

Autorzy:

Panahi, B.
Mohammadi, S.A.
Ebrahimie, E.

Powiązania:

https://bibliotekanauki.pl/articles/81192.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

microRNA
gene expression
halophytic plant
Thellungiella halophila
Expressed Sequence Tag programme
target protein
gene identification

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 40.

Tytuł:

SSCP polymorphism within 5 region of bovine lactoglobulin [LGB] gene

Autorzy:

Kaminski, S
Zabolewicz, T.

Powiązania:

https://bibliotekanauki.pl/articles/2044462.pdf

Data publikacji:

1998

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

lactoglobulin gene
polymorphism
SSCP method
cattle
gene transcription
electrophoresis
hormonal receptor
mutation
beta-lactoglobulin
milk

Opis:

In the paper the detection of the SSCP polymorphism within the 5’ fragment of bovine beta-lactoglobulin (LGB) gene is described. The 5’ fragment of LGB gene (209 bp) was PCR-amplified and then subjected to electrophoresis allowing the detection of SSCP polymorphism. Among 124 animals (50 cows and 74 bulls) six SSCP patterns were identified and named Rl, R2, R3, R4, R5 and R6, which occured with the frequency of 0.32, 0.51, 0.09, 0.06, 0.01 and 0.01, respectively. The PCR-SSCP method is simple, fast, and relatively inexpensive. The SSCP polymorphism reported in the paper may be useful in looking for the associations between different SSCP patterns and LGB gene expression and milk properties.

Źródło:

Journal of Applied Genetics; 1998, 39, 1; 97-102
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 41.

Tytuł:

Isolation of the DNA fragment reflecting the open reading frame II of the I-18 C gene of Chironomus tentans by the polymerase chain reaction. V. Different mechanisms of regulation regarding the open reading frames

Autorzy:

Borowicz, B P

Powiązania:

https://bibliotekanauki.pl/articles/64980.pdf

Data publikacji:

1997

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

regulation mechanism
gene expression
I-18 C gene
Chironomus tentans
polymerase chain reaction
DNA fragment

Opis:

Different mechanisms of regulation regarding the Open Reading Frames (ORFs) have been discussed to have a broader perspective that is necessary to evaluate the role of the ORFs of the I-18 C gene. This consideration includes the ORF II of the I-18 C gene which is the object of the presented research.
Omówiono różnorodne mechanizmy regulacji dotyczące Otwartych Ram Odczytu, w celu wytworzenia szerszego spojrzenia na to zagadnienie, które jest potrzebne do oceny roli poszczególnych Otwartych Ram Odczytu (ORF) genu I-18 C. Omówienie to dotyczy również ORF II genu I-18 C, co było przedmiotem zaprezentowanych badań.

Źródło:

Journal of Plant Protection Research; 1997, 37, 1-2
1427-4345

Pojawia się w:

Journal of Plant Protection Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 42.

Tytuł:

Isolation of the DNA fragment reflecting the open reading frame II of the I-18 C gene of Chironomus tentans by the polymerase chain reaction. III. The DNA amplification technology

Autorzy:

Borowicz, B P

Powiązania:

https://bibliotekanauki.pl/articles/66760.pdf

Data publikacji:

1997

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

gene expression
I-18 C gene
Chironomus tentans
polymerase chain reaction
DNA fragment
DNA amplification

Opis:

The technology used to amplify and isolate the DNA fragment reflecting the Open Reading Frame II of the I-18 C gene of Chironomus tentans is described i.e. the Polymerase Chain Reactioin and the agarose gel electrophoresis of this reaction product, as well as the blunting reaction of the product and its isolation.
Opisano technologię zastosowaną do powielenia i izolacji fragmentu DNA odpowiadającego Otwartej Ramie Odczytu II genu I-18 C Chironomus tentans, tj. Reakcję Łańcuchową Polimerazy (PCR) oraz elektroforezę w żelu agarozowym produktu tej reakcji jak również reakcję tzw. Stępiania końców wyżej wymienionego produktu i ostatecznie jego izolację .

Źródło:

Journal of Plant Protection Research; 1997, 37, 1-2
1427-4345

Pojawia się w:

Journal of Plant Protection Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 43.

Tytuł:

Performance of transgenic pigs produced with the use of two different growth hormone gene constructs

Autorzy:

Rozycki, M
Smorag, Z.
Kopchick, J.J.
Chen, W.Y.
Jura, J.
Pasieka, J.
Orzechowska, B
Gajda, B.
Skrzyszowska, M.

Powiązania:

https://bibliotekanauki.pl/articles/2043872.pdf

Data publikacji:

1999

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

pig
transgenic pig
gene
performance trait
coding gene
genetic engineering
growth hormone

Źródło:

Journal of Applied Genetics; 1999, 40, 1; 29-37
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 44.

Tytuł:

Intra-population genetic diversity of cultivated carrot (Daucus carota L.) assessed by analysis of microsatellite markers

Autorzy:

Maksylewicz, Anna
Baranski, Rafal

Powiązania:

https://bibliotekanauki.pl/articles/1039480.pdf

Data publikacji:

2013

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

SSR
biodiversity
genetic structure
gene pool

Opis:

Intra-population variation of 18 cultivated carrot (Daucus carota L. ssp. sativus) populations of diverse origins was evaluated using codominant microsatellite (SSR) markers. Using 27 genomic and EST-derived SSR markers, 253 alleles were identified with a mean 9.4 alleles per marker. Most of the alleles (60.5%) were rare i.e., with the frequency ≤ 0.05 while only 3.95% of alleles occurred with frequency > 0.6. EST-derived SSR markers were less polymorphic than genomic SSR markers. Differences in allele occurrence allowed 16 out of 18 populations to be assigned to either the Western or Asian carrot gene pools with high probability. Populations could be also discriminated due to the presence of private alleles (25.3% of all alleles). Most populations had excess of alleles in the homozygous state indicating their inbreeding, although heterozygous loci were common in F1 hybrids. Genetic diversity was due to allelic variation among plants within populations (62% of total variation) and between populations (38%). Accessions originating from continental Asia and Europe had more allelic variants and higher diversity than those from Japan and USA. Also, allelic richness and variability in landraces was higher than in F1 hybrids and open-pollinated cultivars.

Źródło:

Acta Biochimica Polonica; 2013, 60, 4; 753-760
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 45.

Tytuł:

VDR gene single nucleotide polymorphisms and their association with risk of oral cavity carcinoma

Autorzy:

Małodobra-Mazur, Małgorzata
Paduch, Agnieszka
Lebioda, Arleta
Konopacka, Maria
Rogoliński, Jacek
Szymczyk, Cezary
Wierzgoń, Janusz
Maciejewski, Adam
Chmielik, Ewa
Jonkisz, Anna
Półtorak, Stanisław
Dobosz, Tadeusz

Powiązania:

https://bibliotekanauki.pl/articles/1039670.pdf

Data publikacji:

2012

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

VDR gene
SNP
oral cavity cancer

Opis:

Vitamin D3 (1,25(OH)2D3 (1,25-dihydroxyvitamin D3)) is a hormone playing a crucial role in numerous biological processes in the human body, including induction and control of cell proliferation and differentiation. Numerous data relate the vitamin D3 level with various types of cancer. It has been suggested that SNPs in the vitamin D3 receptor (VDR) gene might influence both the risk of cancer occurrence and cancer progression. The aim of this study was to search for genetic correlations between individual SNPs in the VDR gene and the risk of oral cavity carcinoma. Two SNPs were selected based on the literature and our previous results. Seventy-three patients with squamous cell carcinoma of the head and neck and one hundred control subjects were investigated. Two SNPs in the VDR gene were genotyped in minisequencing reactions followed by capillary electrophoresis. Hardy-Weinberg equilibrium (HWE), the χ2 test and logistic regression were used for statistical analysis. The SNP rs2238135 in the VDR gene displayed statistical differences in frequency between the tested groups (p=0,0007). Furthermore, the G/C genotype of the rs2238135 in the VDR gene was characterized by a 3.16 fold increased risk of oral cavity carcinoma. The obtained results provide evidence for a genetic association between rs2238135 in the VDR gene and the occurrence and risk of oral cavity cancer.

Źródło:

Acta Biochimica Polonica; 2012, 59, 4; 627-630
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 46.

Tytuł:

A newly identified Thr99fsX110 mutation in the PMP22 gene associated with an atypical phenotype of the hereditary neuropathy with liability to pressure palsies

Autorzy:

Moszyńska, Izabela
Kabzińska, Dagmara
Sinkiewicz-Darol, Elena
Kochański, Andrzej

Powiązania:

https://bibliotekanauki.pl/articles/1040475.pdf

Data publikacji:

2009

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

HNPP neuropathy
PMP22 gene mutations

Opis:

Hereditary neuropathy with liability to pressure palsies (HNPP) is manifested by a spectrum of phenotypes, from the classical HNPP course associated with intermittent nerve palsies to a neuropathy resembling Charcot-Marie-Tooth type 1 (CMT1) disease. The majority of HNPP cases are associated with submicroscopical deletions in the 17p11.2-p12 region containing the PMP22 gene, while PMP22 point mutations are rare, representing about 15% of HNPP cases. In this study, we present a patient manifesting with atypical HNPP phenotype associated with a new Thr99fsX110 mutation in the PMP22 gene. We conclude that all patients who fulfill the electrophysiological criteria of HNPP, even if they lack the typical HNPP phenotype, should be tested for point mutations in the PMP22 gene.

Źródło:

Acta Biochimica Polonica; 2009, 56, 4; 627-630
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 47.

Tytuł:

Involvement of the essential yeast DNA polymerases in induced gene conversion

Autorzy:

Hałas, Agnieszka
Ciesielski, Arkadiusz
Żuk, Jerzy

Powiązania:

https://bibliotekanauki.pl/articles/1044442.pdf

Data publikacji:

1999

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

gene conversion
DNA polymerases
Saccharomyces cerevisiae

Opis:

In the yeast Saccharomyces cerevisiae three different DNA polymerases α, δ and ε are involved in DNA replication. DNA polymerase α is responsible for initiation of DNA synthesis and polymerases δ and ε are required for elongation of DNA strand during replication. DNA polymerases δ and ε are also involved in DNA repair. In this work we studied the role of these three DNA polymerases in the process of recombinational synthesis. Using thermo-sensitive heteroallelic mutants in genes encoding DNA polymerases we studied their role in the process of induced gene conversion. Mutant strains were treated with mutagens, incubated under permissive or restrictive conditions and the numbers of convertants obtained were compared. A very high difference in the number of convertants between restrictive and permissive conditions was observed for polymerases α and δ, which suggests that these two polymerases play an important role in DNA synthesis during mitotic gene conversion. Marginal dependence of gene conversion on the activity of polymerase ε indicates that this DNA polymerase may be involved in this process but rather as an auxiliary enzyme.

Źródło:

Acta Biochimica Polonica; 1999, 46, 4; 862-872
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 48.

Tytuł:

Combination of vasostatin gene therapy with cyclophosphamide inhibits growth of B16(F10) melanoma tumours

Autorzy:

Jazowiecka-Rakus, Joanna
Jarosz, Magdalena
Szala, Stanisław

Powiązania:

https://bibliotekanauki.pl/articles/1041289.pdf

Data publikacji:

2006

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

angiogenesis
combination
vasostatin
cyclophosphamide
gene therapy

Opis:

Angiogenesis, i.e. formation of new blood vessels out of pre-existing capillaries, is essential to the development of tumour vasculature. The discovery of specific antiangiogenic inhibitors has important therapeutic implications for the development of novel cancer treatments. Vasostatin, the N-terminal domain of calreticulin, is a potent endogenous inhibitor of angiogenesis and tumour growth. In our study, using B16(F10) murine melanoma model and electroporation we attempted intramuscular transfer of human vasostatin gene. The gene therapy was combined with antiangiogenic drug dosing schedule of a known chemotherapeutic (cyclophosphamide). The combination of vasostatin gene therapy and cyclophosphamide administration improved therapeutic effects in melanoma tumours. We observed both significant inhibition of tumour growth and extended survival of treated mice. To our knowledge, this is one of the first reports showing antitumour efficacy of electroporation-mediated vasostatin gene therapy combined with antiangiogenic chemotherapy.

Źródło:

Acta Biochimica Polonica; 2006, 53, 1; 199-202
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 49.

Tytuł:

Plant-derived rhamnogalacturonan-I’s modulate proinflammatory cytokine gene expression in neutrophils stimulated by E. coli LPS and P. gingivalis bacteria

Autorzy:

Folkert, J.
Mieszkowska, A.
Burke, B.
Addison, O.
Gurzawska, K.

Powiązania:

https://bibliotekanauki.pl/articles/285453.pdf

Data publikacji:

2018

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

pectin
PMN
proinflammatory cytokines
gene expression

Opis:

Titanium dental implants often induce the foreign body immune response. The duration of the inflammatory process determines the initial stability and biocompatibility of the implant. The challenge for bone tissue engineering is to develop implant biocompatible and bioactive surface coatings that regulate the inflammatory response and enhance osseointegration. Pectins, plant-derived polysaccharides, have been shown to be potential candidates for surface coating due to their possible roles in improving osseointegration and bone healing. The aim of this study was to evaluate in vitro the effect of plant-derived pectin rhamnogalacturonan-I (RG-I) nanocoating on pro- and anti-inflammatory human polymorphonuclear leucocytes (PMN) responses to E. coli LPS or P. gingivalis bacteria. In this study unmodified RG-I and structurally modified RG-I from potato were examined. All in vitro studies were performed on tissue culture polystyrene surfaces (TCPS) or titanium (Ti) discs coated with unmodified and modified RG-Is. Changes in PMN gene expression occurred on both surfaces. The presence of RG-Is down-regulated proinflammatory genes, IL1B, IL8, TNFA. Our results clearly showed that pectin RG-I nanocoating decreased the level of proinflammatory genes expression in stimulated PMN and may therefore be considered as a potential candidate for modulation of the inflammatory response elicited by insertion of implants into living tissue.

Źródło:

Engineering of Biomaterials; 2018, 21, 144; 2-7
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 50.

Tytuł:

Sequence variants of Yersinia enterocolitica ystB gene detected in wild animals in Poland

Autorzy:

Pieczywek, M.
Bancerz-Kisiel, A.
Szczerba-Turek, A.
Szweda, W.

Powiązania:

https://bibliotekanauki.pl/articles/2087747.pdf

Data publikacji:

2018

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

Yersinia enterocolitica
ystB gene
phylogenetic analysis

Źródło:

Polish Journal of Veterinary Sciences; 2018, 21, 2; 397-399
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 51.

Tytuł:

Ocena ekspresji genu ABCC1 kodującego białko MRP1 u osób chorych na depresję
Evaluation of ABCC1 gene expression, encoding MRP1, in patients with depression

Autorzy:

Świechowski, Rafał
Balcerczak, Ewa
Żebrowska, Marta
Jeleń, Agnieszka

Powiązania:

https://bibliotekanauki.pl/articles/1032567.pdf

Data publikacji:

2015

Wydawca:

Łódzkie Towarzystwo Naukowe

Tematy:

depresja
abcc1
mrp1
farmakogenetyka
ekspresja genu
major depression
abcc1 gene
pharmacogenetics
gene
expression

Opis:

Introduction: According to the World Health Organization, depression is the most common mental disorder. Over 350 million people suffer from this disease, making it the fourth most important health problem in the world. Multidrug resistance protein 1 (MRP1), encoded by ABCC1 gene is co–creating the blood– brain barrier and blood–cerebrospinal fluid barrier. Changes in the expression of ABCC1 can influence the bioavailability of antidepressants, and thereby, determine the efficacy of the treatment. The aim of the study was to evaluate ABCC1 gene expression in patients with depression. Material and methods: We analyzed 32 samples of RNA isolated from the leukocytes of peripheral blood, derived from Babinski Hospital patients suffering from recurrent depressive episodes. The investigated gene expression was assessed using the technique of Real–time PCR. Results: On the basis of qualitative analysis, ABCC1 gene expression has been shown in 30 samples, and the GAPDH gene expression in 32 samples. All 32 samples were quantitatively analyzed. The level of ABCC1 gene expression relative to GAPDH gene was variable among all 32 cases. An average, positive and significant correlation (r = 0.3988) between age of the patients and the relative expression level of ABCC1 has been shown. Conclusions: The relative level of gene expression increases with the age of the patients with depression. The obtained results require confirmation in a larger group of patients.
Wstęp: Według Światowej Organizacji Zdrowia depresja jest najczęściej występującym zaburzeniem psychicznym. Ponad 350 milionów ludzi na całym świecie cierpi na tę chorobę, co czyni ją czwartym z najważniejszych obecnie problemów zdrowotnych. Białko oporności wielolekowej 1 (MRP1), kodowane przez gen ABCC1, jest elementem współtworzącym barierę krew–mózg oraz krew–płyn mózgowo–rdzeniowy. Zmiana ekspresji genu ABCC1 może wpłynąć na biodostępność leków antydepresyjnych, a tym samym na skuteczność farmakoterapii. Celem pracy była ocena ekspresji genu ABCC1 u pacjentów chorych na depresję. Materiał i metody: Badaniu poddano 32 próby RNA wyizolowane z leukocytów krwi obwodowej pacjentów chorych na depresję, leczonych w szpitalu im. Babińskiego w Łodzi. Ekspresja badanego genu została oceniona przy użyciu techniki Real–time PCR. Wyniki: Na podstawie analizy jakościowej wykazano ekspresję genu ABCC1 w 30 próbach, a genu referencyjnego GAPDH w 32 próbach. Wszystkie 32 próby poddano analizie ilościowej. Poziom ekspresji genu ABCC1 względem genu GAPDH we wszystkich 32 przypadkach był wysoce zróżnicowany. Wykazano przeciętną, dodatnią, istotną statystycznie korelację (r = 0,398 pomiędzy wiekiem pacjentów, a względnym poziom ekspresji genu ABCC1. Wnioski: Względny poziom ekspresji genu ABCC1 jest tym wyższy, im wyższy jest wiek pacjentów w grupie badanej. Uzyskane w pracy wyniki badań wymagają potwierdzenia na większej grupie pacjentów.

Źródło:

Folia Medica Lodziensia; 2015, 42, 2; 107-122
0071-6731

Pojawia się w:

Folia Medica Lodziensia

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 52.

Tytuł:

SURF1 gene mutations in Polish patients with COX-deficient Leigh syndrome

Autorzy:

Piekutowska-Abramczuk, D
Popowska, E.
Pronicka, E.
Karczmarewicz, E.
Pronicki, M.
Kmiec, T.
Krajewska-Walasek, M.

Powiązania:

https://bibliotekanauki.pl/articles/2041946.pdf

Data publikacji:

2001

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

Leigh disease
polymorphism
deletion
patient
substitution
Polska
SURF1 gene
gene mutation
Leigh syndrome
cytochrome oxidase

Źródło:

Journal of Applied Genetics; 2001, 42, 1; 103-108
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 53.

Tytuł:

Introns of plant pri-miRNAs enhance miRNA biogenesis

Autorzy:

Bielewicz, D.
Kalak, M.
Kalyna, M.
Windels, D.
Barta, A.
Vazquez, F.
Szweykowska-Kulinska, Z.
Jarmolowski, A.

Powiązania:

https://bibliotekanauki.pl/articles/80799.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

conference
microRNA
biogenesis
small RNA
gene expression
environment condition
intron
protein-coding gene

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 54.

Tytuł:

A comprehensive in silico prediction of the most deleterious missense variants in the bovine LEP gene

Autorzy:

Al-Shuhaib, M.B.S.

Powiązania:

https://bibliotekanauki.pl/articles/80824.pdf

Data publikacji:

2019

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

LEP gene
leptin
biological activity
bovine gene
single nucleotide polymorphism
coding sequence
cattle

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 4
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 55.

Tytuł:

Carrier-state of D allele in ACE gene insertion/deletion polymorphism is associated with coronary artery disease, in contrast to the C677→T transition in the MTHFR gene.

Autorzy:

Żak, Iwona
Niemiec, Paweł
Sarecka, Beata
Balcerzyk, Anna
Ciemniewski, Zbigniew
Rudowska, Ewa
Dyląg, Stanisław

Powiązania:

https://bibliotekanauki.pl/articles/1043632.pdf

Data publikacji:

2003

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

angiotensin converting enzyme gene (ACE)
coronary artery disease
methylenetetrahydrofolate reductase gene (MTHFR)
polymorphisms

Opis:

Angiotensin I-converting enzyme (ACE), which plays an important role in blood pressure regulation, and methylenetetrahydrofolate reductase (MTHFR) involved in homocysteine metabolism belong to a large group of polypeptides which may be potential risk factors for atherosclerosis and coronary artery disease (CAD). To assess whether polymorphisms of the genes encoding these peptides are associated with CAD in Silesian we conducted a study among 68 individuals suffering from CAD (including 52 cases after myocardial infarction), 51 subjects with positive family history of CAD and 111 controls. We analysed the distribution of genotypes and allele frequencies of the insertion/deletion (I/D) polymorphism in the ACE gene using PCR amplification, and the C677→T polymorphism in the MTHFR gene using PCR-RFLP analysis. We found that D allele frequency was significantly higher in CAD patients (61%) than in controls (43%) (P = 0.001, OR = 2.06). The D allele carriers (DD + ID genotypes) were more frequent in the CAD patients (85%) compared to control group (65%) (P = 0.003, OR = 3.14), whereas the familial CAD risk group shows the highest frequency of the ID genotype (57% vs 43% in controls). In contrast, the MTHFR polymorphism does not seem to be associated with the disease. Our data indicate that in Silesian CAD patients the disease is strongly associated with carrier-state of the ACE D allele, but not with the C677→T transition in the MTHFR gene.

Źródło:

Acta Biochimica Polonica; 2003, 50, 2; 527-534
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 56.

Tytuł:

Intermedium mutants in barley [Hordeum vulgare L.] - diversity, interactions and plant breeding value

Autorzy:

Lundqvist, U
Lundqvist, A.

Powiązania:

https://bibliotekanauki.pl/articles/2044458.pdf

Data publikacji:

1998

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

mutant combination
gene interaction
diversity
barley
mutation
Hordeum vulgare
intermedium gene
plant breeding

Opis:

Mutation research has given an insight into the rather complex genetics of kernel rows in barley. At least 12 gene loci can act to promote the spike development, fertility, and kernel development. Mutants with such effects as sixrow and intermedium phenotypes show clear morphological distinctions among different loci, but also among different allelic mutants. These genes, without exception, are capable of unexpected synergistic reinforcing or disturbing intraction, the extremes being typically six-rowed or deformed spikes, respectively. The investigations have centered on 69 intermedium mutants, representing 9 loci, in double mutant combinations, in double combinations with the six-row gene hex-v, in triple combinations with hex-v, and in triple and quadruple mutant combinations. The effects of the interaction may differ among the three characters of lateral floret development, among intermedium loci, and among alleles of the particular locus. Particular types of gene interaction are indicated, particular loci being more competent than others, and the particular alleles being more competent in relation to the constellation of loci. Accumulation of intermedium genes in more complex gene systems leads to progressive promotion of lateral floret development, but there are indications that such systems may be more sensitive to environmental stress, leading to irregular or even deformed spike formation. Probably, representatives of the hex-v locus should form the fundamental constituent in the synthesis of gene systems with the most efficient promotion of lateral floret development in the breeding of six-row barley.

Źródło:

Journal of Applied Genetics; 1998, 39, 1; 85-96
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 57.

Tytuł:

Isolation of the DNA fragment reflecting the open reading frame II of the I-18 C gene of Chironomus tentans by the polymerase chain reaction. II. The technology for the preparation of the template

Autorzy:

Borowicz, B P

Powiązania:

https://bibliotekanauki.pl/articles/65476.pdf

Data publikacji:

1997

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

gene expression
I-18 C gene
Chironomus tentans
polymerase chain reaction
DNA fragment

Opis:

The technology for the preparation of the template in the research aimed to isolate the DNA fragment reflecting the Open Reading Frame II of the I-18 C gene is presented i.e. the linearisation of the template by Bam H I digestion, the purification of the template and the estimation of the template concentration.
Przedstawiono technologię przygotowywania matrycy DNA w badaniach zmierzających do izolacji Otwartej Ramy Odczytu II genu I-18 C Chironomus tentans. Technologia ta obejmowała linearyzację DNA matrycy poprzez trawienie Bam H I oraz oczyszczenie matrycy i oznaczenie stężenia matrycowego DNA.

Źródło:

Journal of Plant Protection Research; 1997, 37, 1-2
1427-4345

Pojawia się w:

Journal of Plant Protection Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 58.

Tytuł:

Testowanie przypuszczenia Beala z wykorzystaniem klasycznych procesorów
Testing Beal conjecture using classical processors

Autorzy:

Kwiatkowska, M.
Świerczewski, Ł.

Powiązania:

https://bibliotekanauki.pl/articles/131917.pdf

Data publikacji:

2015

Wydawca:

Wrocławska Wyższa Szkoła Informatyki Stosowanej Horyzont

Tematy:

przypuszczenie Beal’a
Blue Gene/P
Blue Gene/Q
Power 775
Beal conjecture

Opis:

Praca obejmuje testowanie przypuszczenia Beal'a z wykorzystaniem klasycznych procesorów. Dodatkowo w wybranych funkcjach oprogramowania wykorzystano standard OpenMP, co umożliwiło zrównoleglenie obliczeń. Do obliczeń wykorzystano jednostki obliczeniowe wchodzące w skład komputerów IBM Blue Gene/P, IBM Blue Gene/Q oraz IBM Power 775. Testy wykonano także na superkomputerze HP BladeSystem/Actina, Hydra dostępnym w ICM UW - użyto tam węzła obliczeniowego posiadającego dwa procesory Intel Xeon X5660. Porównano wydajność własnych rozwiązań napisanych w języku C z możliwościami oprogramowania napisanego w języku Python przez Peter'a Novig'a.
This paper includes the testing of Beal’s conjecture using classical processors. Additionally some features of OpenMP standard were used in software what allowed to parallel the calculation. Calculations were based on computational units included in the computers IBM Blue Gene/L, IBM Blue Gene/Q, and the IBM Power 775 tests have been performed on the supercomputer HP BladeSystem / Actina, Hydra available in the ICM UW - computing nodes with Intel Xeon processors X5660 were used there. The performance of own solutions written in C was compared with the capabilities of software written in Python by Peter Novig.

Źródło:

Biuletyn Naukowy Wrocławskiej Wyższej Szkoły Informatyki Stosowanej. Informatyka; 2015, 5; 27-35
2082-9892

Pojawia się w:

Biuletyn Naukowy Wrocławskiej Wyższej Szkoły Informatyki Stosowanej. Informatyka

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 59.

Tytuł:

MMP-10, MMP-7, TIMP-1 and TIMP-2 mRNA expression in esophageal cancer

Autorzy:

Juchniewicz, Agnieszka
Kowalczuk, Oksana
Milewski, Robert
Laudański, Wojciech
Dzięgielewski, Piotr
Kozłowski, Mirosław
Nikliński, Jacek

Powiązania:

https://bibliotekanauki.pl/articles/1038650.pdf

Data publikacji:

2017

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Esophageal cancer
gene expression
metalloproteinases

Opis:

Introduction: Tissue inhibitors of metalloproteinases (TIMP) and the matrix metalloproteinases (MMP) are involved in the spread of cancer. Methods: We have evaluated the matrix metalloproteinases' (MMP-10, MMP-7) and their inhibitors' (tissue inhibitors of metalloproteinases - TIMP-1, TIMP-2) mRNA expression in 61 esophageal cancer samples from patients who had undergone surgery, by using real-time quantitative RT-PCR, and correlated the results with the patient clinicopathologic features. Results: MMP-10, MMP-7, TIMP-1, TIMP-2 were overexpressed in 73%, 85%, 55% and 42% of esophageal cancer samples, respectively. The expression of MMP-10, TIMP-1, and TIMP-2 correlated with the tumor size. The MMP-7 overexpression was associated with the tumour stage (I, II vs III, p=0.05) and lymph node metastasis (N0 vs N1, p=0.037). Conclusions: We conclude that in the resected esophageal cancer an increased mRNA expression of MMP-7, MMP-10 and TIMP-1 correlated with clinicopathologic features. We suggest that these genes may play a role during progression of the disease.

Źródło:

Acta Biochimica Polonica; 2017, 64, 2; 295-299
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 60.

Tytuł:

Detection of C677T & A1298C mutations within the MTHFR gene by PCR and RFLP assays and assessment of risk factor of Hyperhomocysteinemia

Autorzy:

Amarakoon, A. A. D. Gayathri Upeksha
Fernandopulle, Neil

Powiązania:

https://bibliotekanauki.pl/articles/1182887.pdf

Data publikacji:

2016

Wydawca:

Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN

Tematy:

mthfr gene
dna methylation
hyperhomocysteinemia

Opis:

The MTHFR gene within the human genome, codes for the synthesis of Methylenetetrahydrofolate Reductase enzyme, which reduces 5,10-Methylenetetrahydrofolate to 5-Methyltetrahydrofolate, which in turn, is the major circulatory form of folate in the blood. Folate, in this form, among it’s other functions, is involved in reducing the homocysteine levels in the blood, whose elevated levels lead to Hyperhomocysteinemia, causing various major disorders. Mutations within the gene lead to impairment of gene function, in turn causing the homocysteine levels to rise. The C677T and A1298C mutations are the main causative agents for MTHFR gene disruption. During the course of the project, a total of 79 samples were analyzed for the presence of these mutations. The blood samples were first subjected to PCR, giving two separate DNA fragments each responsible for either of the conditions. The fragments were then subjected to RFLP analysis to detect the mutations. The results were finally given with respect to the risk factor faced by each individual based on a molecular diagnostic point of view.

Źródło:

World Scientific News; 2016, 53, 3; 253-274
2392-2192

Pojawia się w:

World Scientific News

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 61.

Tytuł:

Evolutionary Algorithm that Designs the DNA Synthesis Procedure

Autorzy:

Michalak, M.
Nowak, R.

Powiązania:

https://bibliotekanauki.pl/articles/308431.pdf

Data publikacji:

2011

Wydawca:

Instytut Łączności - Państwowy Instytut Badawczy

Tematy:

bioinformatics
gene synthesis
optimum searching

Opis:

Chemical synthesis of nucleotide chains is very erroneous for long sequences. Often a gene is constructed from short fragments joined with the use of complementary helper chains. The number of possible potential solutions for a long gene synthesis is very large, therefore a fast automated search is required. In the presented approach a modified method of long DNA construction is proposed. A computer program that searches for an optimal solution in the space of potential synthesis methods has been developed. This software uses an evolutionary algorithm for global optimization and a hillclimbing algorithm for local optimization. The long DNA construction method was tested on random sequences. The results are very promising. The next step is to perform experiments in a biotechnological wet laboratory involving DNA strand synthesis using the method designed by the presented software.

Źródło:

Journal of Telecommunications and Information Technology; 2011, 4; 50-54
1509-4553
1899-8852

Pojawia się w:

Journal of Telecommunications and Information Technology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 62.

Tytuł:

Resistance of triticale hybrids with Pm4b and Pm6 genes to powdery mildew

Autorzy:

Kowalczyk, K.
Gruszecka, D.
Nowak, M.
Lesniowska-Nowak, J.

Powiązania:

https://bibliotekanauki.pl/articles/19714.pdf

Data publikacji:

2011

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

plant resistance
resistance
triticale
hybrid
Pm4b gene
Pm6 gene
powdery mildew
resistance gene
Blumeria graminis
foliar disease
plant disease

Opis:

Powdery mildew, caused by Blumeria graminis f. sp. tritici, is one of the most important foliar diseases of cereals. Infection by this pathogen on triticale has intensified in Poland in the last few years. In this study we examined resistance to powdery mildew in triticale hybrids possessing resistance genes Pm4b and Pm6 introduced from common wheat. The materials tested were hybrids derived from triticale crosses with common wheat cultivars carrying the desired resistance genes. The presence of the transferred genes was reflected in increased field resistance and shown by the use of molecular markers. The paper discusses the potential introduction of the genes to improve powdery mildew resistance.

Źródło:

Acta Biologica Cracoviensia. Series Botanica; 2011, 53, 1
0001-5296

Pojawia się w:

Acta Biologica Cracoviensia. Series Botanica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 63.

Tytuł:

Molecular typing of Staphylococcus aureus based on PCR-RFLP of coa gene and RAPD analysis

Autorzy:

Karakulska, J.
Pobucewicz, A.
Nawrotek, P.
Muszynska, M.
Furowicz, A.J.
Czernomysy-Furowicz, D.

Powiązania:

https://bibliotekanauki.pl/articles/31963.pdf

Data publikacji:

2011

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

molecular typing
Staphylococcus aureus
PCR-RFLP method
coa gene
random amplified polymorphic DNA analysis
mastitis
nuc gene
gap gene
milk sample
species identification

Opis:

The aim of this study was molecular identification of S. aureus strains isolated from mastitic milk samples and establishing the genetic relationship between strains isolated from cows belonging to the same herd. In all 43 isolated strains the gap gene (930 bp) was amplified, which enabled their affiliation to the Staphylococcus genus to be established. PCR-RFLP with AluI endonuclease of the gap gene as well as nuc (450 bp) and coa (1130 bp) gene amplification allowed precise S. aureus species identification. One hundred percent of the genetic relationship between strains was established via RAPD-PCR and coa-typing.

Źródło:

Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 64.

Tytuł:

Different statins produce highly divergent changes in gene expression profiles of human hepatoma cells: a pilot study

Autorzy:

Leszczynska, Agata
Gora, Monika
Plochocka, Danuta
Hoser, Grazyna
Szkopinska, Anna
Koblowska, Marta
Iwanicka-Nowicka, Roksana
Kotlinski, Maciej
Rawa, Katarzyna
Kiliszek, Marek
Burzynska, Beata

Powiązania:

https://bibliotekanauki.pl/articles/1039868.pdf

Data publikacji:

2011

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

gene expression
statins
microarrays
human hepatoma cells

Opis:

Statins are inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), the key enzyme of the sterol biosynthesis pathway. Statin therapy is commonly regarded as well tolerated. However, serious adverse effects have also been reported, especially during high-dose statin therapy. The aim of our study was to investigate the effect of statins on gene expression profiles in human hepatoma HepG2 cells using Affymetrix Human Genome U133 Plus 2.0 arrays. Expression of 102, 857 and 1091 genes was changed substantially in HepG2 cells treated with simvastatin, fluvastatin and atorvastatin, respectively. Pathway and gene ontology analysis showed that many of the genes with changed expression levels were involved in a broad range of metabolic processes. The presented data clearly indicate substantial differences between the tested statins.

Źródło:

Acta Biochimica Polonica; 2011, 58, 4; 635-639
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 65.

Tytuł:

Combination of IL-12 gene therapy and CTX chemotherapy inhibits growth of primary B16(F10) melanoma tumors in mice

Autorzy:

Mitrus, Iwona
Delić, Klaudia
Wróbel, Natalia
Missol-Kolka, Ewa
Szala, Stanisław

Powiązania:

https://bibliotekanauki.pl/articles/1041249.pdf

Data publikacji:

2006

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

antiangiogenic therapy
interleukin-12 gene
combined therapy

Opis:

We investigated suppression of murine B16(F10) melanoma tumor growth following a therapy which involved concomitant administration of cyclophosphamide and plasmid DNA bearing interleukin-12 gene. Since both therapeutic factors display antiangiogenic capabilities, we assumed that their use in blocking the formation of new blood vessels would result in augmented inhibition of tumor growth. This combined therapy regimen indeed resulted in a considerable suppression of tumor growth. We observed a statistically significant extension of treated animals' lifespan. Interestingly, the therapeutic effect was also obtained using a plasmid without an interleukin gene insert. This observation suggests that plasmid DNA, which has been widely applied for treating neoplastic tumors, contains element(s) that elicit immune response in mice.

Źródło:

Acta Biochimica Polonica; 2006, 53, 2; 357-360
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 66.

Tytuł:

Newest therapeutic options for adrenoleukodystrophy

Autorzy:

Gołębiowska, Maria
Gołębiowska, Beata
Beń-Skowronek, Iwona

Powiązania:

https://bibliotekanauki.pl/articles/1163988.pdf

Data publikacji:

2018

Wydawca:

Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN

Tematy:

X-ALD
adrenoleukodystrophy
gene therapy
neurodegenerative disorders

Opis:

X-linked adrenoleukodystrophy is a genetic disease correlated with mutation of ATP-binding cassette, which results in errors of peroxisomal beta oxidation and accumulation of impaired very long chain fatty acids. This leads to degeneration of adrenal glands, spinal cord and myelin sheaths. Despite nearly 100 years of ALD history, the treatment is limited to few therapeutic options, mainly Lorenzo’s Oil and Hematopoetic stem cell transplant. Available therapy can only slow the progression of the disease in early stages. The aim of our study was to present the newest therapeutic options in X-ALD. Substantial articles on new treatment of X-ALD from period 2007-2018 in the Asian, European and American regions have been analyzed. Among 219 articles in PubMed Medline database related to therapy and treatment of X-ALD, 13 articles were selected for analysis, reviewed and divided into two main groups: cause-related treatment (11 articles) and symptoms-related treatment (2 articles). Within cause-related treatment, the usage of known medications such as eg. pioglitazone, natural phenols - resveratrol, gene therapy with adenoassociated virus serotype 9 or combined therapies (Hematopoetic Stem Cell Gene Therapy) have been reviewed. Symptoms related treatment attempted to reduce spasticity and secondary dystonia in X-ALD patients. Reviewed research presents progress in development of treatment options for X-ALD, however still in primary in vitro and animal tested stages. Secondary neurological symptoms medication is awaiting for better solutions for ALD patients, in order to improve their Quality of Life and allow symptomless course for a longer time.

Źródło:

World Scientific News; 2018, 108; 133-143
2392-2192

Pojawia się w:

World Scientific News

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 67.

Tytuł:

Helper-dependent adenoviral vectors in experimental gene therapy

Autorzy:

Józkowicz, Alicja
Dulak, Józef

Powiązania:

https://bibliotekanauki.pl/articles/1041362.pdf

Data publikacji:

2005

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

helper-dependent adenoviral vectors
adenoviruses
gene therapy

Opis:

In the majority of potential applications gene therapy will require an effective transfer of a transgene in vivo resulting in high-level and long-term transgene expression, all in the absence of significant toxicity or inflammatory responses. The most efficient vehicles for delivery of foreign genes to the target tissues are modified adenoviruses. Adenoviral vectors of the first generation, despite the high infection efficacy, have an essential drawback: they induce strong immune response, which leads to short term expression of the transgene, and limits their usefulness in clinical trials. In contrast, helper-dependent adenoviral vectors (HdAd) lacking all viral coding sequences display only minimal immunogenicity and negligible side-effects, allowing for long-term transgene expression. Thus, HdAd vehicles have become the carrier of choice for adenoviral vector-mediated experimental gene therapy, effectively used in animal models for delivery of transgenes into the liver, skeletal muscle, myocardium or brain. Strong and long-lasting expression of therapeutic genes has allowed for successful treatment of dyslipidemias, muscular dystrophy, obesity, hemophilia, and diabetes. Additionally, the large cloning capacity of HdAd, up to 37 kb, facilitates the use of physiologically regulated, endogenous promoters, instead of artificial viral promoter sequences. This enables also generation of the single vectors expressing multiple genes, which can be potentially useful for treatment of polygenic diseases. In this review we characterize the basic features of HdAd vectors and describe some of their experimental and potential clinical applications.

Źródło:

Acta Biochimica Polonica; 2005, 52, 3; 589-599
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 68.

Tytuł:

An introduction to DNA chips: principles, technology, applications and analysis.

Autorzy:

Gabig, Magdalena
Węgrzyn, Grzegorz

Powiązania:

https://bibliotekanauki.pl/articles/1044090.pdf

Data publikacji:

2001

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

gene expression
DNA array
oligonucleotide array
hybridisation

Opis:

This review describes the recently developed GeneChip technology that provides efficient access to genetic information using miniaturised, high-density arrays of DNA or oligonucleotide probes. Such microarrays are powerful tools to study the molecular basis of interactions on a scale that would be impossible using conventional analysis. The recent development of the microarray technology has greatly accelerated the investigation of gene regulation. Arrays are mostly used to identify which genes are turned on or off in a cell or tissue, and also to evaluate the extent of a gene's expression under various conditions. Indeed, this technology has been successfully applied to investigate simultaneous expression of many thousands of genes and to the detection of mutations or polymorphisms, as well as for their mapping and sequencing.

Źródło:

Acta Biochimica Polonica; 2001, 48, 3; 615-622
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 69.

Tytuł:

Metabolic enzymes that bind RNA: yet another level of cellular regulatory network?

Autorzy:

Cieśla, Joanna

Powiązania:

https://bibliotekanauki.pl/articles/1041266.pdf

Data publikacji:

2006

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

enzymes
gene expression
mRNA binding
translation regulation

Opis:

Several enzymes that were originally characterized to have one defined function in intermediatory metabolism are now shown to participate in a number of other cellular processes. Multifunctional proteins may be crucial for building of the highly complex networks that maintain the function and structure in the eukaryotic cell possessing a relatively low number of protein-encoding genes. One facet of this phenomenon, on which I will focus in this review, is the interaction of metabolic enzymes with RNA. The list of such enzymes known to be associated with RNA is constantly expanding, but the most intriguing question remains unanswered: are the metabolic enzyme-RNA interactions relevant in the regulation of cell metabolism? It has been proposed that metabolic RNA-binding enzymes participate in general regulatory circuits linking a metabolic function to a regulatory mechanism, similar to the situation of the metabolic enzyme aconitase, which also functions as iron-responsive RNA-binding regulatory element. However, some authors have cautioned that some of such enzymes may merely represent "molecular fossils" of the transition from an RNA to a protein world and that the RNA-binding properties may not have a functional significance. Here I will describe enzymes that have been shown to interact with RNA (in several cases a newly discovered RNA-binding protein has been identified as a well-known metabolic enzyme) and particularly point out those whose ability to interact with RNA seems to have a proven physiological significance. I will also try to depict the molecular switch between an enzyme's metabolic and regulatory functions in cases where such a mechanism has been elucidated. For most of these enzymes relations between their enzymatic functions and RNA metabolism are unclear or seem not to exist. All these enzymes are ancient, as judged by their wide distribution, and participate in fundamental biochemical pathways.

Źródło:

Acta Biochimica Polonica; 2006, 53, 1; 11-32
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 70.

Tytuł:

Polyamine plays a role in subculture growth of in vitro callus of indica rice

Autorzy:

Tan, Yanping
Hu, Wen
Xu, Xin
Zhou, Jie
Wang, Chuntai
Liu, Xuequn
Cheng, Gang

Powiązania:

https://bibliotekanauki.pl/articles/952026.pdf

Data publikacji:

2017

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

browning
callus
gene expression
indica rice
polyamine

Opis:

In vitro embryogenic callus is a critical factor for genetic transformation of rice, especially for indica varieties. In this study, we investigated the relationship between polyamines, including putrescine (Put), spermidine (Spd) and spermine (Spm), and callus browning, and we studied the effect of exogenous Put on callus regeneration and on the content of endogenous polyamines. In addition, the expression levels of arginine decarboxylase gene (Adc1) and S-adenosylmethionine decarboxylase gene (Samdc) in embryogenic callus were studied by quantitative Real-time PCR analysis. The results showed that the contents of endogenous Put and Spd in the browning callus were significantly lower than those in normal callus. Exogenous Put could effectively improve the growing state of callus of indica rice and enhance the development of embryogenic callus. The content of endogenous polyamines in embryogenic callus, especially Spd and Spm, was increased after addition of exogenous Put. Additionally, exogenous Put also had an obvious impact on the expression levels of Adc1 but partial effect on the expression levels of Samdc gene. This study could increase the knowledge of both embryogenic callus induction and polyamine catabolism in callus in indica rice.

Źródło:

Acta Biologica Cracoviensia. Series Botanica; 2017, 59, 1
0001-5296

Pojawia się w:

Acta Biologica Cracoviensia. Series Botanica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 71.

Tytuł:

Molecular biology of sporadic vestibular schwannomas including genetic and epigenetic alterations

Autorzy:

Makuszewska, Maria
Litwiniuk-Kosmala, Małgorzata
Bartoszewicz, Robert
Niemczyk, Kazimierz

Powiązania:

https://bibliotekanauki.pl/articles/1399235.pdf

Data publikacji:

2020

Wydawca:

Index Copernicus International

Tematy:

gene expression
merlin
microRNA
molecular biology
neuroblastoma

Opis:

Introduction: Vestibular schwannomas (VS) are benign tumors developing from the myelin-producing Schwann cells, which surround the vestibular branches of the auditory nerve. The vast majority occur sporadically and a small proportion are associated with neurofibromatosis type 2 (NF2). Most sVS are slow-growing neoplasms; however some have a cystic structure, show more rapid growth, cause more frequently paralysis of the facial nerve, and brainstem compression. The molecular hallmark of both sporadic and NF-2 associated VS is the inactivation of the tumor-suppressor gene NF2, also called merlin gene. Purpose: The paper presents the current knowledge on the molecular biology of VS, including: information on genetic and epigenetic aberrations, changes in gene expression and specific microRNA expression profiles.

Źródło:

Polski Przegląd Otorynolaryngologiczny; 2020, 9, 3; 23-29
2084-5308
2300-7338

Pojawia się w:

Polski Przegląd Otorynolaryngologiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 72.

Tytuł:

Conceptualization of the Gene in Richard Dawkins’ The Selfish Gene

Autorzy:

Drogosz, Anna

Powiązania:

https://bibliotekanauki.pl/articles/2016189.pdf

Data publikacji:

2017

Wydawca:

Komisja Nauk Filologicznych Polskiej Akademii Nauk, Oddział we Wrocławiu

Tematy:

personification
blending
selfish gene
metaphor in science

Opis:

This paper investigates the conceptualization of the gene in the book The Selfish Gene by Richard Dawkins from the point of view of the Conceptual Metaphor Theory and the Conceptual Blending Theory. It is argued that there are two senses of the gene: gene1 is a physically existing section of the DNA, gene2 is information about protein synthesis. It is the second sense of the concept of the gene that undergoes metaphorization. The analysis reveals that Dawkins’ gene is a conceptual blend which becomes extensively elaborated. Through elaboration the gene becomes personified on the one hand and deified on the other. The study shows the richness of Dawkins’ personification: the gene is conceptualized as building and controlling organisms, cooperating and competing with other genes, even showing personality traits. Deification of the gene is focused on highlighting its stipulated immortality and power to create organisms, humans included. The gene blend is at the same time used as an input space in the integration network producing the meme blend. It is also established that the personification of the gene plays the theory-constitutive role in the sense of Boyd (1993).

Źródło:

Academic Journal of Modern Philology; 2017, 6; 75-84
2299-7164
2353-3218

Pojawia się w:

Academic Journal of Modern Philology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 73.

Tytuł:

Semantic-enabled hybrid genetic disease diagnostics in Next-Generation Sequenced data

Autorzy:

Zawadzka-Gosk, E.
Wołk, K.

Powiązania:

https://bibliotekanauki.pl/articles/305569.pdf

Data publikacji:

2018

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Wydawnictwo AGH

Tematy:

gene prioritization
variant prioritization
semantical text analysis

Opis:

Next Generation Sequencing is a technology for genome sequencing used in genetics for the diagnosis of disease. NGS provides a list of all mutations in a genome, so identifying the one that causes a disease is not trivial. A number of applications for variant prioritization were developed, but the data they provide is a suggestion rather than a diagnosis; moreover, they sufer from issues such as identifying a nonpathogenic variant as a causal one or the inability to identify a causal gene. These issues inspired us to create a strategy for variant prioritization, which includes the use of the Exomiser and OMIM Explorer result sets improved by semantic analysis of abstracts and articles freely available from the PubMed and PubMed Central databases. For the wider scope of scientific articles, the Google Scholar repository will be used. The described approach enables us to present the latest and most accurate information about potential pathogenic variants.

Źródło:

Computer Science; 2018, 19 (2); 179-199
1508-2806
2300-7036

Pojawia się w:

Computer Science

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 74.

Tytuł:

Data mining methods for gene selection on the basis of gene expression arrays

Autorzy:

Muszyński, M.
Osowski, S.

Powiązania:

https://bibliotekanauki.pl/articles/329803.pdf

Data publikacji:

2014

Wydawca:

Uniwersytet Zielonogórski. Oficyna Wydawnicza

Tematy:

gene expression array
gene ranking
feature selection
clusterization measures
fusion
SVM classification
ekspresja genów
selekcja cech
klasyfikacja SVM

Opis:

The paper presents data mining methods applied to gene selection for recognition of a particular type of prostate cancer on the basis of gene expression arrays. Several chosen methods of gene selection, including the Fisher method, correlation of gene with a class, application of the support vector machine and statistical hypotheses, are compared on the basis of clustering measures. The results of applying these individual selection methods are combined together to identify the most often selected genes forming the required pattern, best associated with the cancerous cases. This resulting pattern of selected gene lists is treated as the input data to the classifier, performing the task of the final recognition of the patterns. The numerical results of the recognition of prostate cancer from normal (reference) cases using the selected genes and the support vector machine confirm the good performance of the proposed gene selection approach.

Źródło:

International Journal of Applied Mathematics and Computer Science; 2014, 24, 3; 657-668
1641-876X
2083-8492

Pojawia się w:

International Journal of Applied Mathematics and Computer Science

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 75.

Tytuł:

Hyperuricosuria in the domestic dog (Canis lupus familiaris)
Hiperurykozuria u psa (Canis lupu familiaris)

Autorzy:

Gruszczyńska, J.
Szydłowska, K.
Łopieńska, M.
Siewruk, K.
Jundziłł-Bogusiewicz, P.
Grzegrzółka, B.

Powiązania:

https://bibliotekanauki.pl/articles/29433598.pdf

Data publikacji:

2022

Wydawca:

Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie

Tematy:

dog
animal disease
metabolic disease
hyperuricosuria
SLC2A9 gene
gene mutation
GLUT9

Źródło:

Acta Scientiarum Polonorum. Zootechnica; 2022, 21, 3; 13-18
1644-0714

Pojawia się w:

Acta Scientiarum Polonorum. Zootechnica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 76.

Tytuł:

Plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G promoter polymorphism is not associated with breast cancer.

Autorzy:

Błasiak, Janusz
Smolarz, Beata

Powiązania:

https://bibliotekanauki.pl/articles/1044431.pdf

Data publikacji:

2000

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

gene polymorphism
PAI-1 gene
prognostic marker
plasminogen activator inhibitor-1 (PAI-1)
breast cancer

Opis:

The antigen content of plasminogen activator inhibitor-1 (PAI-1) in primary breast cancer tissue extracts may be of strong prognostic value: high levels of PAI-1 in tumors predict poor prognosis for patients. The gene encoding PAI-1 is highly polymorphic and an insertion (5G)/deletion (4G) polymorphism in the PAI-1 gene promoter (the 4G/5G polymorphism), may have functional significance in PAI-1 expression. In the present work the distribution of genotypes and frequency of alleles of the 4G/5G polymorphism in subjects with breast cancer were investigated. Tumor tissues were obtained from 100 postmenopausal women with node-negative and node-positive ductal breast carcinoma with uniform tumor size. Blood samples from age matched healthy women served as control. The 4G/5G polymorphism was determined by PCR amplification using the allele specific primers. The distribution of the genotypes of the 4G/5G polymorphism in both control and patients did not differ significantly (P > 0.05) from those predicted by the Hardy-Weinberg distribution. There were no differences in the genotype distributions and allele frequencies between node-positive and node-negative patients. The 4G/5G polymorphism may not be linked with elevated level of PAI-1 observed in breast cancer and therefore may not be associated with appearance and/or progression of breast cancer.

Źródło:

Acta Biochimica Polonica; 2000, 47, 1; 191-199
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 77.

Tytuł:

The relation of PON1-L55M gene polymorphism and clinical manifestation of Behcets disease

Autorzy:

Dursun, Ahmet
Cicek, Salih
Keni, Fatih
Karakas-Celik, Sevim
Sezer, Tuna
Altinyazar, Cevdet

Powiązania:

https://bibliotekanauki.pl/articles/1039286.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

PON1 gene
Polymorphism
Behçet's disease

Opis:

Purpose: Behçet's disease is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, gastrointestinal, neurologic, and vascular manifestations. Paraoxonase is believed to play an important role in protection of LDL and HDL particles from oxidation, in antioxidant effect against lipid peroxidation on cellular membranes, and in anti-inflammatory process. Lipid peroxidation and free oxygen radicals have been thought to play a role in pathogenesis of BD. The association of paraoxonase gene polymorphisms with Behçet's Disease in a group of Turkish patients with clinical manifestations and healthy controls has been investigated. Patients and Methods: Paraoxonase (PON-1-L55M) gene polymorphism was investigated in 50 Behcet patients and 50 healthy individuals with a PCR/RFLP method. Results: There were significant differences between patients and the control group in allele frequencies of the PON1 L55M polymorphism (p=0.04). Also, when patients were compared with the control group according to clinical manifestations, this statistical significance was getting sharper. Compared with the PON55 L allele, the M allele was associated with greater than 3.5 fold (OR 3.5, 95% CI 1.3-8.9) increased risk of ocular (OR 2.4, 95% CI 1.1-5.3), 2.4 fold joint and 3.1 fold (OR 3.1, 95% CI 1.1-8.4) central nervous system manifestations of BD. Conclusion The PON L55M gene polymorphism seemed to play a role in the pathogenesis of BD.

Źródło:

Acta Biochimica Polonica; 2014, 61, 2; 271-274
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 78.

Tytuł:

Gene expression alterations induced by low molecular weight heparin during bowel anastomosis healing in rats

Autorzy:

Krześniak, Natalia
Paziewska, Agnieszka
Rubel, Tymon
Skrzypczak, Magdalena
Mikula, Michał
Dzwonek, Artur
Goryca, Krzysztof
Wyrwicz, Lucjan
Jarosz, Dorota
Laubitz, Daniel
Woszczyński, Marek
Bielecki, Krzysztof
Ostrowski, Jerzy

Powiązania:

https://bibliotekanauki.pl/articles/1039955.pdf

Data publikacji:

2011

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

heparins
gene expression
wound healing
microarrays

Opis:

Colon anastomosis is therapeutically challenging because multiple, usually undetectable factors influence a spectrum of repair mechanisms. We hypothesized that low molecular weight heparins, routinely administered perioperatively, may differentially affect gene expression related to colon healing. Twenty pairs of untreated and enoxaparin-treated rats underwent left-side hemicolectomy with a primary end-to-end anastomosis. Normal colon and anastomotic bowel segments were resected on day 0 and on days 1, 3, 5, and 7 after surgery, respectively. Serial anastomosis transverse cross-sections were evaluated microscopically and by microarray (Rat Genome 230 2.0, Affymetrix). Differentially expressed probe sets were annotated with Gene Ontology. We also examined the influence of enoxaparin on fibroblast proliferation and viability in vitro. Among the 5476 probe sets, we identified differential expression at each healing time point, yielding 79 subcategories. Most indicated genes were involved in wound healing, including multicellular organismal development, locomotory behavior, immune response, cell adhesion, inflammatory response, cell-cell signaling, blood vessel development, and tissue remodeling. Although we found no intensity differences in histological features of healing between enoxaparin-treated and control rats, treatment did induce significant expression changes during early healing. Of these changes, 83 probe sets exhibited at least twofold changes and represented different functional annotations, including inflammatory response, regulation of transcription, regulation of apoptosis, and angiogenesis. Fibroblast culture confirmed an anti-viability effect of enoxaparin. Enoxaparin affects colon wound-related gene expression profiles, but further studies will resolve whether heparin treatment is a risk factor after intestinal surgery, at least in some patients.

Źródło:

Acta Biochimica Polonica; 2011, 58, 1; 79-87
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 79.

Tytuł:

K-ras gene mutation as an early prognostic marker of colon cancer

Autorzy:

Szpon, Łukasz
Stal, Aleksander
Zawadzki, Marcin
Lis-Nawara, Anna
Kielan, Wojciech
Grzebieniak, Zugmunt
Kelan, Wojciech
Grzebiak, Zygmunt

Powiązania:

https://bibliotekanauki.pl/articles/1394055.pdf

Data publikacji:

2016

Wydawca:

Index Copernicus International

Tematy:

K-ras gene mutation
colorectal cancer

Opis:

Due to increased colorectal cancer incidence there is a necessity of seeking new both prognostic and prediction factors that will allow to evolve new diagnostic tests. K-ras gene seems to be such a factor and its mutations are considered to be an early marker of progression of colorectal cancer. The aim of the study was to find a correlation between K-ras gene mutation in patients with diagnosed colorectal cancer and selected clinical parameters. Material and methods. A total of 104 patients (41 women and 63 men) with diagnosed colorectal cancer were included in this study. The average age of male group was 68.3 and in female group – 65.9. Samples were taken from paraffine blocks with tissue from diagnosed patients and K-ras gene mutation were identified. Afterwards the statistical analysis was made seeking the correlation betweenK-ras gene mutation incidence and clinical TNM staging system, tumour localisation, histological type, sex, age. Results. K-ras gene mutations were detected in 20.1% of all colorectal cancers. Significantly higher rate of K-ras gene mutations were diagnosed among patients classified at stage I (40%), stage IIC (50%) and stage IV (50%) according to the TNM classification. Conclusions. The results of our study are compatible with other studies and indicate the correlation between K-ras gene mutation and colorectal cancer incidence. Identification of K-ras gene mutation may complement other diagnostic methods at early stage of colorectal cancer.

Źródło:

Polish Journal of Surgery; 2016, 88, 1; 15-19
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 80.

Tytuł:

Inheritance of some morphological traits and yield components in induced mutants of winter wheat variety Flevina.

Autorzy:

Grzesik, Helena

Powiązania:

https://bibliotekanauki.pl/articles/2198784.pdf

Data publikacji:

2000-12-20

Wydawca:

Instytut Hodowli i Aklimatyzacji Roślin

Tematy:

winter wheat
mutants
inheritance
gene effects

Opis:

Previously (Grzesik 1980) a number of induced mutants with shortened culm increased loging resistance and changed shape of ear and leaves were obtained from winter wheat var. Flevina. Two of the obtained mutants were crossed with the initial variety to study the mode of  inheritance of the mutated traits such as culm length, ear length, grain weight per ear and boat-like leaf shape. The hybrids were sown in experiment with six basic generations: P1, P2, F1, F2, BC1, BC2. The mode of inheritance of the above traits proved to be very complex. Both additive and nonadditive effects of gene action played a significant role. Basing on genetic analysis it can be concluded that a boat-like shape of leaves is determined by two complementary recessive genes.

Źródło:

Plant Breeding and Seed Science; 2000, 44; 45-52
1429-3862
2083-599X

Pojawia się w:

Plant Breeding and Seed Science

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 81.

Tytuł:

Materiały kolekcyjne owsa w Krajowym Centrum Roślinnych Zasobów Genowych
Oat collection of the National Centre for Plant Genetic Resources

Autorzy:

Dziubińska, Dorota
Podyma, Wiesław

Powiązania:

https://bibliotekanauki.pl/articles/2199903.pdf

Data publikacji:

2020-10-22

Wydawca:

Instytut Hodowli i Aklimatyzacji Roślin

Tematy:

owies
zasoby genowe
oat
gene resourses

Opis:

Owies jest jednym z najważniejszych zbóż uprawianych na świecie. Ziarno owsa znajduje zastosowanie w produkcji żywności, pasz oraz w przemyśle. W celu zachowania różnorodności gatunków owsa w Krajowym Centrum Roślinnych Zasobów Genowych powstała kolekcja obejmująca zarówno uprawne jak i dzikie jego formy. Zadaniem kolekcji jest zarówno gromadzenie jak również ocena i charakterystyka zebranych obiektów.
Oats are among the most important cereals grown in the world. Oat grains are used in the production of food, animal feed and in industry. In order to conserve the diversity of oat species, a collection including both cultivated and wild forms was established at the National Centre for Plant Genetic Resources. The main task of the collection is also the collection and evaluation of collected accessions.

Źródło:

Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin; 2020, 290; 5-7
0373-7837
2657-8913

Pojawia się w:

Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 82.

Tytuł:

Apoplastic ROS sensing and signalling

Autorzy:

Kangasjarvi, J.

Powiązania:

https://bibliotekanauki.pl/articles/80047.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

conference
reactive oxygen species
signalling
plant cell
stress adaptation
acclimation
cysteine-rich protein
extracellular protein
gene regulation
marker gene

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 83.

Tytuł:

Influence of Epilobium angustifolium extract on 5alpha-reductase type 2 and MAPK3 kinase gene expression in rats prostates
Wpływ wyciągu z Epilobium angustifolium na ekspresję genów 5alfa-reduktazy typu 2 oraz kinazy MAPK3 w szczurzych prostatach

Autorzy:

Kujawski, R.
Bartkowiak-Wieczorek, J.
Karasiewicz, M.
Bogacz, A.
Mikolajczak, P.L.
Czerny, B.
Mrozikiewicz, P.M.

Powiązania:

https://bibliotekanauki.pl/articles/72333.pdf

Data publikacji:

2013

Wydawca:

Instytut Włókien Naturalnych i Roślin Zielarskich

Tematy:

Epilobium angustifolium
plant extract
5alpha-reductase type 2
Mapk3 gene
kinase
gene expression
rat
prostate
androgen receptor

Opis:

The aim of this study was to investigate the influence of standardized Epilobium angustifolium L. extract [100 mg/kg/day, p.o.] on the expression level of 5α-reductase type 2 (Srd5ar2) mRNA and Mapk3 mRNA a representative of non-genomic xenobiotics signaling pathway. It was shown that plant extract from the E. angustifolium showed a slight tendency to reduce prostate weight in hormonally induced animals (p>0.05) and in testosterone induced animals receiving both, extract and finasteride (p<0.05). Finasteride in rats induced by testosterone caused a smaller decrease in the level of mRNA 5α-steroid reductase 2 (SRd5ar2), than in rats treated with the hormone and studied plant extracts. In general, an increase in the amount of MAPK3 mRNAs in testosterone-induced groups of rats receiving tested plant extract with or without finasteride was observed, while the expression of type 2 5α-steroid reductase decreased (p<0.05). Further experimental studies should be performed in order to understand the molecular basis of interactions, the efficacy and safety of tested plant extracts.
Celem pracy było zbadanie wpływu standaryzowanego ekstraktu z ziela Epilobium angustifolium L. [100 mg/kg/dzień, p.o.] na poziom ekspresji mRNA 5α-reduktazy typu 2 (SRd5ar2) oraz mRNA kinazy MAPK3 – przedstawiciela androgenozależnego, nie-genomowego szlaku sygnalizacji komórkowej. W zastosowanym modelu eksperymentalnym wyciąg z z E. angustifolium wykazał statystycznie nieistotną, niewielką tendencję do zmniejszania masy prostat u zwierząt indukowanych hormonalnie (p>0,05) oraz u szczurów indukowanych testosteronem, otrzymujących zarówno ekstrakt, jak i finasteryd (p<0,05). Finasteryd u szczurów otrzymujących testosteron spowodował mniejsze, aniżeli zakładano, obniżenie poziomu mRNA 5α-reduktazy typu 2 (SRd5ar2), niż u szczurów, którym podano hormon i badany wyciąg (p <0.05). Stwierdziliśmy ponadto, zwiększenie ilości mRNA kinazy MAPK3 u szczurów indukowanych testosteronem otrzymujących badany ekstrakt, wraz z finasterydem lub bez niego, podczas gdy ekspresja reduktazy w tych grupach uległa zwiększeniu (p <0,05). Należy przeprowadzić dalsze badania eksperymentalne w celu zrozumienia molekularnych podstaw oddziaływań, skuteczności i bezpieczeństwa badanych ekstraktów roślinnych.

Źródło:

Herba Polonica; 2013, 59, 4
0018-0599

Pojawia się w:

Herba Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 84.

Tytuł:

p53-dependent suppression of the human calcyclin gene (S100A6): the role of Sp1 and of NFκB

Autorzy:

Króliczak, Weronika
Pietrzak, Maciej
Puzianowska-Kuznicka, Monika

Powiązania:

https://bibliotekanauki.pl/articles/1040715.pdf

Data publikacji:

2008

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

gene suppression
wild type and mutant p53
Sp1
calcyclin gene (S100A6)
NFκB

Opis:

Calcyclin (S100A6) is believed to participate in cell cycle control. It was, however, unclear if its expression depends on p53, a key regulator of apoptosis and cell cycle. We therefore performed transcription regulation assays in HeLa cells and found that wild type p53 suppressed the S100A6 promoter up to 12-fold in a dose-dependent manner. In contrast, the well-characterized V143A, R175H, R249S, and L344A p53 mutants cloned from human cancers suppressed this promoter with a 6 to 9-fold lower efficiency. All the sites mediating the p53-dependent suppression were contained in the -167 to +134 fragment of the S100A6 promoter. Separate overexpression of either Sp1 or of NFκB only partially counteracted the p53 inhibitory effect on the S100A6 promoter, while simultaneous overexpression of both these transactivators resulted in a complete abolishment of the p53 inhibitory effect on this promoter. Sp1 and NFκB binding to the probes resembling their putative binding sites present in the S100A6 promoter was decreased in the presence of wild type p53. We propose that the suppression of S100A6 is yet another mechanism by which p53 inhibits proliferation. Insufficient suppression of this gene by p53 mutants could well be responsible for calcyclin overexpression and cell cycle deregulation observed in cancer tissues.

Źródło:

Acta Biochimica Polonica; 2008, 55, 3; 559-570
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 85.

Tytuł:

Frequency of transgression and gene distribution in barley doubled haploid populations from first and second cycle hybrids

Autorzy:

Surma, M
Adamski, T.
Kaczmarek, Z.
Kapala, A.

Powiązania:

https://bibliotekanauki.pl/articles/2044239.pdf

Data publikacji:

1998

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

transgression
gene dispersion
doubled haploid
grain yield
hybrid
barley
first cycle hybrid
second cycle hybrid
recurrent selection
gene distribution

Opis:

Barley doubled haploids (DH) derived from first and second cycle hybrids were investigated in field experiments. Parental lines designed for the second cycle hybrids were three doubled haploids from the first cycle hybrids, which were observed to have the highest grain yield. Yield structure characters, crude protein content and protein fractions were analysed. Phenotypic and genetic variability and the frequency of transgression in the studied populations were calculated. For the studied traits additive, [d], and epistatic (additive x additive), [i], effects as well as coefficient of gene dispersion were estimated. It was found that the phenotypic and genetic variability of DH populations derived from second cycle hybrids was higher than that of the original population for all the studied traits except grain yield. A greater proportion of transgressive lines than in the original population was also observed in populations from second cycle hybrids. Only one DH line exceeding the high yielding parent was found among 141 lines under study. The relationship between the frequency of transgressions and gene dispersion was recorded: the greatest number of transgressive lines occurred in those traits for which the dispersion was observed.

Źródło:

Journal of Applied Genetics; 1998, 39, 3; 237-247
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

/5

Artykuł

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Skocz do pozycji: 86.

Tytuł:

Lead tolerance mechanisms in Robinia pseudoaccacia L. - an attempt to a practical approach
Mechanizmy tolerancji na ołów u Robinia pseudoaccacia L. i ich aspekt praktyczny

Autorzy:

Wińska-Krysiak, M.
Bernat, J.

Powiązania:

https://bibliotekanauki.pl/articles/11541679.pdf

Data publikacji:

2008

Wydawca:

Uniwersytet Przyrodniczy w Lublinie. Wydawnictwo Uniwersytetu Przyrodniczego w Lublinie

Tematy:

Lead tolerance
tolerance mechanism
Robinia pseudoaccacia
practical approach
lead
glutathione
phytochelatin
root
RpPCS gene
RpGSH1 gene
soil contamination

Opis:

Robinia pseudoaccacia plants grown hydroponically were treated Pb(NO3)2 with 15, 45 mg Pb²⁺ ∙ dm⁻³. After 6, 12, 24, 72 hours of the metal treatment the plants were collected and dissected organs. The plants accumulated and transported to ground part 0.88% and 1.35% of total accumulated lead for the lower and higher dose of Pb²⁺ respectively. The level of GSH was differed and depended on organs, dose and time treatment of Pb²⁺. We investigate (different pattern of expression) expression of RpGSH1 and RpPCS genes in roots. The study showed that glutathione and genes encoded enzymes connected with synthesis of him, plays important role in the process of detoxification in plant.
Rośliny robinii akacjowej uprawianej w hydroponice traktowane były Pb(NO3)2 w ilościach: 0, 15, 45 mg Pb²⁺ ∙ dm⁻³. Materiał roślinny zbierano po 6, 12, 24 i 72 godzinach od traktowania ołowiem i rozdzielono na organy. Procent pobranego ołowiu w przeliczeniu na suchą masę roślin przetransportowany do części nadziemnej wynosił 0,88 dla najwyższej dawki traktowania oraz 1,35 dla niższej. Poziom glutationu był zróżnicowany i zależał od badanego organu, dawki i czasu od potraktowania ołowiem. Odnotowano zróżnicowaną ekspresję RpGSH1 i RpPCS w korzeniach roślin. Badania wykazały, że glutation i geny szlaku jego biosyntezy odgrywają ważną rolę w procesie detoksykacji ołowiu w roślinie.

Źródło:

Acta Scientiarum Polonorum. Hortorum Cultus; 2008, 07, 3; 77-86
1644-0692

Pojawia się w:

Acta Scientiarum Polonorum. Hortorum Cultus

Dostawca treści:

Biblioteka Nauki

/5

Artykuł

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Skocz do pozycji: 87.

Tytuł:

Immunolocalization of AGO1 in female gametophyte cells of Hyacinthus orientalis L. before and after fertilization

Autorzy:

Niedojadlo, K.
Mehelewska, M.
Niedojadlo, J.
Bednarska-Kozakiewicz, E.

Powiązania:

https://bibliotekanauki.pl/articles/80092.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

conference
microRNA
gene expression
protein-coding gene
immunolocalization
AGO1 protein
female gametophyte
Hyacinthus orientalis
fertilization

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

Artykuł

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Skocz do pozycji: 88.

Tytuł:

Transcriptional activity changes of the SOC1 homologue in vegetative organs in Lupinus luteus

Autorzy:

Wojciechowski, W.
Glazinska, P.
Banach, M.
Wilmowicz, E.
Kucko, A.
Marciniak, K.
Kesy, J.
Kopcewicz, J.
Tretyn, A.

Powiązania:

https://bibliotekanauki.pl/articles/80925.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

conference
transcriptional activity
vegetative organ
Lupinus luteus
yellow lupin
gene
gene homologue
plant flowering
development stage

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

Artykuł

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Skocz do pozycji: 89.

Tytuł:

Interference of nematode parasitism by silencing of plant genes

Autorzy:

Koter, M.
Matuszkiewicz, M.
Baranowski, L.
Sobczak, M.
Wisniewska, A.
Dabrowska-Bronk, J.
Swiecicka, M.
Skowron, W.
Filipecki, M.

Powiązania:

https://bibliotekanauki.pl/articles/80931.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

conference
nematode
crop rotation
parasitism
plant gene
gene silencing
GTP-binding protein
plant fertility
biotic stress

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

Artykuł

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Skocz do pozycji: 90.

Tytuł:

Molecular interactions between the microRNA biogenesis complex and the spliceosome

Autorzy:

Stepien, A.
Kierzkowski, D.
Raczynska, K.D.
Szweykowska-Kulinska, Z.
Jarmolowski, A.

Powiązania:

https://bibliotekanauki.pl/articles/80969.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

conference
molecular interaction
microRNA
biogenesis
spliceosome
gene expression
protein-coding gene
nuclear cap-binding protein complex

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

Artykuł

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Skocz do pozycji: 91.

Tytuł:

Comparison of the nuclear organiser region activity in four taxa of the family Canidae

Autorzy:

Pienkowska, A
Zagalska, M.

Powiązania:

https://bibliotekanauki.pl/articles/2041199.pdf

Data publikacji:

2001

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

nuclear organiser region activity
gene cluster
rRNA
sex chromosome
genetics
Canidae
racoon dog
karyotype
rRNA gene

Źródło:

Journal of Applied Genetics; 2001, 42, 4; 493-501
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 92.

Tytuł:

On spins and genes

Autorzy:

Miękisz, Jacek
Szymańska, Paulina

Powiązania:

https://bibliotekanauki.pl/articles/748773.pdf

Data publikacji:

2012

Wydawca:

Polskie Towarzystwo Matematyczne

Tematy:

Ising model, self-regulating gene, mean-field approximation
Ising model, self-regulating gene, mean-field approximation.

Opis:

Naszym celem jest zrozumienie i przewidywanie zachowania się układów wielu oddziałujących obiektów, takich jak cząstki i spiny w fizyce statystycznej czy geny i białka w biologii molekularnej. Jako matematycy pragniemy udowadniać twierdzenia i wyprowadzać analityczne wzory. Bardzo szybko okazuje się, że w istotnych zastosowaniach jest to niemożliwe. Co robić? Część z nas ucieka w wyrafinowane symulacje komputerowe. Czy nie ma innej drogi? Czy jesteśmy ograniczeni do wyboru pomiędzy Matematyką i Mathematicą? Na pomoc przychodzi metoda samouzgodnionego pola średniego. Ferromagnetyczny model Isinga i samoregulujący się gen zilustrują nam tę niezwykle uniwersalną metodę otrzymywania przybliżonych rozwiązań analitycznych.
Many processes in natural and social sciences can be modeled by systems of interacting objects. It is usually very difficult to obtain analytic expressions describing time evolution and equilibrium behavior of such systems. Very often we rely only on computer simulations. Fortunately, in many cases one can construct useful approximation schemes and derive exact results which capture some specific features of a given process. A frequent approach is to replace interactions between objects by a mean interaction. Here we illustrate a self-consistent mean-field approximation in two examples: the Ising model of interacting spins and a simple model of a self-regulating gene.

Źródło:

Mathematica Applicanda; 2012, 40, 1
1730-2668
2299-4009

Pojawia się w:

Mathematica Applicanda

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 93.

Tytuł:

Impact of 3-hydroxybutyrate on the expression of plant histone deacetylases, methylases and crucial genes of the phenylpropanoid pathway

Autorzy:

Mierziak, J.
Dzialo, M.
Kulma, A.
Szopa-Skorkowski, J.

Powiązania:

https://bibliotekanauki.pl/articles/951302.pdf

Data publikacji:

2015

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

conference
3-hydroxybutyrate
histone deacetylase
methylase
gene
phenylpropanoid

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 1
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 94.

Tytuł:

Genetic diversity of local cattle

Autorzy:

Kukučková, Veronika
Moravčíková, Nina
Curik, Ino
Simčič, Mojca
Mészáros, Gábor
Kasarda, Radovan

Powiązania:

https://bibliotekanauki.pl/articles/1038372.pdf

Data publikacji:

2018

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

admixture
clustering
gene flow
genotyping array
Pinzgau cattle

Opis:

The Slovak Pinzgau breed faces the bottleneck effect and the loss of diversity due to unequal use of founders and a significant population decline. Further population size reduction can lead to serious problems. Information obtained here and in other studies from high-throughput genotyping of 179 individuals was used to characterise genetic diversity and differentiation of Slovak Pinzgau, Austrian Pinzgau, Cika and Piedmontese cattle by Bayesian clustering algorithm. A gene flow network for the clusters estimated from admixture results was produced. The low estimate of genetic differentiation (FST) in Pinzgau cattle populations indicated that differentiation among these populations is low, particularly owing to a common historical origin and high gene flow. Changes in the log marginal likelihood indicated Austrian Pinzgau as the most similar breed to Slovak Pinzgau. All populations except the Piedmontese one displayed two ways of gene flow among populations, indicating that Piedmontese cattle was involved in producing of the analysed breeds while these breeds were not involved in creation of Piedmontese. Genetic evaluation represents an important tool in breeding and cattle selection. It is more strategically important than ever to preserve as much of the livestock diversity as possible, to ensure a prompt and proper response to the needs of future generations. Information provided by the fine-scale genetic characterization of this study clearly shows that there is a difference in genetic composition of Slovak and Austrian populations, as well as the Cika and Piedmontese cattle. Despite its population size, the Slovak Pinzgau cattle have a potential to serve as a basic gene reserve of this breed, with European and world-wide importance.

Źródło:

Acta Biochimica Polonica; 2018, 65, 3; 421-424
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 95.

Tytuł:

Type 1 fimbriae in commensal Escherichia coli derived from healthy humans

Autorzy:

Pusz, Paweł
Bok, Ewa
Mazurek, Justyna
Stosik, Michał
Baldy-Chudzik, Katarzyna

Powiązania:

https://bibliotekanauki.pl/articles/1039310.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

commensal E. coli
type 1 fimbriae
gene expression

Opis:

Type 1 fimbriae are one of the most important factors of Escherichia coli adaptation to different niches in the host. Our study indicated that the genetic marker - fimH gene occurred commonly in commensal E. coli derived from healthy humans but expression of the type 1 fimbriae was not observed. Identification of fim structural subunit genes (fimA-fimH) and recombinase fimE and fimB genes showed that many of the strains were carrying an incomplete set of genes and the genes expression study revealed that in strains with complete set of fim genes, the fimC gene, encoding the chaperone protein, was not expressed.

Źródło:

Acta Biochimica Polonica; 2014, 61, 2; 389-392
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 96.

Tytuł:

Isolation and functional expression of a novel lipase gene isolated directly from oil-contaminated soil

Autorzy:

Zuo, Kaijing
Zhang, Lida
Yao, Hongyan
Wang, Jin

Powiązania:

https://bibliotekanauki.pl/articles/1040372.pdf

Data publikacji:

2010

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

meta-genomic library
lipase
gene cloning
hydrolysis activity

Opis:

A lipase gene SR1 encoding an extracellular lipase was isolated from oil-contaminated soil and expressed in Escherichia coli. The gene contained a 1845-bp reading frame and encoded a 615-amino-acid lipase protein. The mature part of the lipase was expressed with an N-terminal histidine tag in E. coli BL21, purified and characterized biochemically. The results showed that the purified lipase combines the properties of Pseudomonas chlororaphis and other Serratia lipases characterized so far. Its optimum pH and temperature for hydrolysis activity was pH 5.5-8.0 and 37°C respectively. The enzyme showed high preference for short chain substrates (556.3±2.8 U/µg for C10 fatty acid oil) and surprisingly it also displayed high activity for long-chain fatty acid. The deduced lipase SR1 protein is probably from Serratia, and is organized as a prepro-protein and belongs to the GXSXG lipase family.

Źródło:

Acta Biochimica Polonica; 2010, 57, 3; 305-311
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 97.

Tytuł:

In vitro co-stimulation of anti-tumor activity by soluble B7 molecules

Autorzy:

He, Wei
Hu, Zhong-Bo
Liu, Fang
Feng, Xian-Qi
Zou, Ping

Powiązania:

https://bibliotekanauki.pl/articles/1041178.pdf

Data publikacji:

2006

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

immunotherapy
tumor escape
gene fusion
recombinant fusion proteins

Opis:

In order to investigate the anti-tumor activity of a soluble B7-1/immunoglobulin G fusion protein and explore an effective method to eliminate immune escape of tumor cells, a recombinant vector encoding this fusion protein was constructed and constitutively expressed in Chinese hamster ovary cells. After purification with protein G affinity chromatography, the soluble fusion protein was tested for bioactivity. Results showed that the fusion protein could significantly increase the density of B7-1 molecules on WEHI-3 cells, a mouse leukemia cell line. Through allogeneic mixed lymphocyte tumor cultures, it was demonstrated that, with the presence of the first signal, it could also significantly enhance T cell activation and killing activity against WEHI-3 cells and interleukin-2 secretion by activated mouse T lymphocytes. The conclusion can be drawn that the soluble B7-IgG fusion protein has a potent capacity to generate or enhance anti-tumor immune response in vitro, and its clinical value deserves further investigation.

Źródło:

Acta Biochimica Polonica; 2006, 53, 4; 807-813
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 98.

Tytuł:

De novo Ser72Leu mutation in the peripheral myelin protein 22 in two Polish patients with a severe form of Charcot-Marie-Tooth disease.

Autorzy:

Kochański, Andrzej
Kabzińska, Dagmara

Powiązania:

https://bibliotekanauki.pl/articles/1041521.pdf

Data publikacji:

2004

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

S72L mutation
PMP22 gene mutations

Opis:

To date, 12 cases of heterozygous Ser72Leu mutations in the peripheral myelin protein 22 have been reported in patients suffering from severe demyelinating form of Charcot-Marie-Tooth disease (CMT1) and congenital hypomyelinating neuropathy (CHN) [MIM# 605253]. In the present study we report two cases of de novo S72L mutations in the PMP22 gene detected in patients of Polish origin suffering from CMT1 disease.

Źródło:

Acta Biochimica Polonica; 2004, 51, 4; 1047-1050
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 99.

Tytuł:

Antitumour activity of Salmonella typhimurium VNP20047 in B16(F10) murine melanoma model.

Autorzy:

Jazowiecka-Rakus, Joanna
Szala, Stanisław

Powiązania:

https://bibliotekanauki.pl/articles/1041570.pdf

Data publikacji:

2004

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

cancer gene therapy
tumour targeting
cytosine deaminase
Salmonella

Opis:

A tumour therapy is proposed based on attenuated Salmonella typhimurium VNP20047 expressing the Escherichia coli cytosine deaminase gene. VNP20047 was administered intravenously to B16(F10) melanoma-bearing C57BL/6 mice. VNP20047 proliferated within tumours and livers regardless of the initial inoculum dose. After 10 days the number of bacteria increased in livers up to 4.2 × 106 cfu/g and decreased in tumours down to 5.9 × 106 cfu/g. VNP20047 at 1 × 105 cfu/mouse, when combined with 5-fluorocytosine, inhibited tumour growth by 85% without prolonging animal survival. Histology studies revealed severe lesions in tumours and livers. These data suggest that S. typhimurium VNP20047 induced inflammatory responses, even though the strain was attenuated.

Źródło:

Acta Biochimica Polonica; 2004, 51, 3; 851-856
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 100.

Tytuł:

Preliminary report on β-casein gene Met183QVal183 polymorphism in Romanian indigenous Zackel sheep breeds

Autorzy:

Kusza, Szilvia
Ilie, Daniela
Sauer, Maria
Sauer, Ioan-Walter
Gavojdian, Dinu

Powiązania:

https://bibliotekanauki.pl/articles/1038660.pdf

Data publikacji:

2017

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

β-casein
gene polymorphism
ovine milk
Racka
Turcana

Opis:

Genetic polymorphisms of the milk protein genes are important because of their effects on quantitative traits and technological properties of milk manufacturing. In the present study we identified the polymorphism of the beta-casein gene in two local sheep breeds (Racka n=98 and Turcana n=111) in Romania. The most studied variants at the ovine beta-casein (CSN2) locus are: A and G variants. Genomic DNA was extracted from hair follicles and beta-casein genotypes were determined by the rapid TaqMan (Applied Biosystems, USA) genotyping assay. Homozygote genotypes GG were not detected in any of the studied breeds. In both, the Racka and Turcana breeds, the A variant had a much higher frequency, 0.98% and 0.97%, respectively. In the current study, the fast DNA tests for genotyping ovine CSN2 were successfully optimized, however, further samples and correlations of genomic results with milk characteristics and production data are needed for the development of future selection schemes of the Romanian indigenous sheep breeds, with the ultimate purpose to produce low allergen level sheep milk and derived dairy products.

Źródło:

Acta Biochimica Polonica; 2017, 64, 2; 339-341
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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