- Tytuł:
- Research of hydrophilic globules containing a lactic acid-chitosan complex
- Autorzy:
- Małolepsza-Jarmołowska, Katarzyna
- Powiązania:
- https://bibliotekanauki.pl/articles/1034096.pdf
- Data publikacji:
- 2020
- Wydawca:
- Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
- Tematy:
-
anti-inflammatory drugs
hydrophilic globules
lactic acid-chitosan complex
physiological environment of vagina
vaginal infections
vaginal mucosa - Opis:
- Gynecological scientific journals report that traditional therapeutic regimens used to treat vaginal inflammation recommended by global treatment centers and health organizations are not producing satisfactory results. Insufficient duration of the drug’s contact with vaginal mucosa does not provide adequate pH conditioning the physiological biocenosis of the organ. The conducted research and obtained positive results encourage further research possibilities in the field of optimization of pharmaceutical properties of the examined gynecological preparations. Assuming the above assumptions tested impact of polyvinylpyrrolidone K-15, polyvinylpyrrolidone K-30 and polyvinylpyrrolidone K-90 in the properties of the globules. The study was prepared formulations with different pH and rheological properties. The device simulating the conditions in the vagina, studied the adhesion and movement of the gel on the mucosa of the organ. Globules after application of the apparatus simulates the natural conditions in the gel passes and cover the surface. A wide range of pH of the gels allows the selection of the optimum formulation.
- Źródło:
-
Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 143-150
1896-5644 - Pojawia się w:
- Progress on Chemistry and Application of Chitin and its Derivatives
- Dostawca treści:
- Biblioteka Nauki
Artykuł