The effect of selected polymers on the properties of thermosensitive hydrophilic gels containing lactic acid complexed with chitosan

Bacterial vaginitis affects women of all age groups. Numerous recurrences of the condition are widely discussed by clinicians. Traditional therapeutic schemes recommended by world treatment centres and health organizations do not bring satisfactory results. Their effects are hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. The investigations demonstrated that the thermosensitive polymer - poloxamer 407 increases significantly the adhesive properties of hydrophilic gels, but at the same time it increases their pH. The addition of PVP K-30 or hydroxypropylmethylcellulose reduces the pH and maintains high adhesion. The use of PVP K-30 and hydroxypropylmethylcellulose allowed to obtain narrow physiological range – lower limits of the physiological range. Rheological investigations revealed an increase in the dynamic viscosity of reparations containing poloxamer 407 with the addition of PVP K-30 or hydroxypropylmethylcellulose in comparison to the reference gels.