- Tytuł:
- The effect of a hydrophilizing substance on the properties of thermosensitive hydrophilic gels containing lactic acid complexed with chitosan
- Autorzy:
- Małolepsza-Jarmołowska, Katarzyna
- Powiązania:
- https://bibliotekanauki.pl/articles/1035479.pdf
- Data publikacji:
- 2011
- Wydawca:
- Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
- Tematy:
-
anti-inflammatory drugs.
hydrophilic gels
lactic acid complexed with chitosan
pectin
thermosensitive polymer-poloxamer 407
vaginal infections - Opis:
- Commonly applied drug forms tend to leave the vagina when the patient assumes an upright position. Permanent contact of the drug form with the vaginal mucosa during daily activities of the patient is an indispensable condition for 24-hour therapy. This condition may be fulfilled by drug forms with high ability to adhere to vaginal mucosa. The investigations demonstrated that the thermosensitive polymer - poloxamer 407 increases significantly the adhesive properties of hydrophilic gels, but at the same time it increases their pH. The use of pectin resulted in a decrease of the pH. The addition of glycerol or 1,2-propylene glycol caused further decrease of the pH. Rheological investigations demonstrated positive pharmaceutical properties of the investigated preparations. The obtained parameters gels should provide positive application effects. The investigations revealed that it is possible to obtain gels with high adhesion properties to vaginal mucous membrane.
- Źródło:
-
Progress on Chemistry and Application of Chitin and its Derivatives; 2011, 16; 105-110
1896-5644 - Pojawia się w:
- Progress on Chemistry and Application of Chitin and its Derivatives
- Dostawca treści:
- Biblioteka Nauki
Artykuł