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Tytuł:
45 Years of Deliberations on the Thermo-Mechanical Interpretation of Friction and Wear. Part I: The Macroscopic Interpretation of the Tribological Process 4
45 lat rozważań o cieplno-mechanicznej interpretacji tarcia i zużywania. Część I: interpretacja makroskopowa procesu tribologicznego
Autorzy:
Sadowski, Jan
Powiązania:
https://bibliotekanauki.pl/articles/2134813.pdf
Data publikacji:
2022
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
thermodynamic system
friction couple
friction area
extensive parameters
wear
dissipation heat
work of mechanical dissipation
enthalpy
internal energy
specific work of wear
first law of thermodynamics
system termodynamiczny
para tarciowa
strefa tarcia
parametr ekstensywny
praca tarcia
zużywanie
ciepło dyssypacji
praca dyssypacji mechanicznej
entalpia
energia wewnętrzna
praca właściwa zużycia
pierwsza zasada termodynamiki
Opis:
This first part will consider the friction couple or its part, identified with the open thermodynamic system. Dependences among extensive parameters and energetic interactions in the system and its boundaries with the environment are described in analytical terms. The dimensions of the energy dissipation zone, where the friction of solids takes place, are established. The thermo-mechanical nature of the tribological process is demonstrated. The wear conditions and distribution of energy generated by its particular elements are determined. A new quantity is introduced – the specific work of wear, which characterises the wear resistance of the tribological system and its parts. The effect of the reciprocal cover of solids’ friction surfaces on the energy balance structure in calorimetric testing is analysed. The concept of generalised wear is introduced and standardised. The discussion is restricted to processes at the macroscopic level of matter organisation.
Przedmiotem rozważań w pierwszej części pracy jest para tarciowa lub jej fragment utożsamiona z systemem termodynamicznym otwartym. Opisano analitycznie zależności między parametrami ekstensywnymi i oddziaływaniami energetycznymi w systemie i na jego graniach z otoczeniem. Ustalono wymiary strefy dyssypacji energii, w której zachodzi tarcie ciał stałych. Wykazano cieplno-mechaniczną naturę procesu tribologicznego. Ustalono warunki zachodzenia zużywania i rozdziału energii rozproszonej przez poszczególne jego elementy. Wprowadzono nową wielkość – pracę właściwą zużycia, charakteryzującą odporność na zużywanie systemu tribologicznego i jego elementów. Zanalizowano wpływ wzajemnego przykrycia powierzchni tarcia ciał na strukturę bilansu energii w badaniach kalorymetrycznych. Wprowadzono pojęcie zużycia uogólnionego i jego standaryzację. Rozważania ograniczono do procesów zachodzących na makroskopowym poziomie hierarchicznym organizacji materii.
Źródło:
Tribologia; 2022, 2; 55--66
0208-7774
Pojawia się w:
Tribologia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A comparative study of thermodynamic electrolyte models applied to the Solvay soda system
Autorzy:
Jaworski, Z.
Czernuszewicz, M.
Gralla, Ł.
Powiązania:
https://bibliotekanauki.pl/articles/185481.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
model termodynamiczny
elektrolit
thermodynamic model
electrolytes
activity coefficients
soda system
Opis:
Fast development of computation techniques for electrolyte activities contributed recently to introduction of a few substantial programmes for thermodynamic computing of multiphase systems. The presented study comprises useful information for practical computing using selected thermodynamic models of aqueous electrolyte solutions. Those models enable quantitative description of both phase and ionic equilibria and provide values of activity coefficients. The carried out analysis of individual models involved a comparison of their practical effectiveness features along with problems encountered in evaluation of the coefficients. The authors conclude that for the Solvay soda system the exUNIQUAC model for an in-house code or the MSE model for a commercial one can be used.
Źródło:
Chemical and Process Engineering; 2011, 32, 2; 135-154
0208-6425
2300-1925
Pojawia się w:
Chemical and Process Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A defnition of near-critical region based on heat capacity variation in transcritical heat exchangers
Autorzy:
Trela, M.
Kwidziński, R.
Butrymowicz, D.
Powiązania:
https://bibliotekanauki.pl/articles/240043.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
krytyczny stan termodynamiczny
obszar około-krytyczny
pojemność cieplna
wymiana ciepła
critical thermodynamic state
heat transfer
near-critical region
speci.c heat capacity
Opis:
In the paper, a method for determination of the near-critical region boundary is proposed. The boundary is evaluated with respect to variations of specific heat capacity along isobars. It is assumed that the value of specific heat capacity inside the near-critical region exceeds by more than 50% the practically constant value typical for fluids under normal conditions. It appears that large variations of heat capacity are also present for high-pressure subcritical states sufficiently close to the critical point. Therefore, such defined near-critical region is located not only in supercritical fluid domain but also extends into subcritical fluid. As an example, the boundaries of the near-critical region were evaluated for water, carbon dioxide and R143a.
Źródło:
Archives of Thermodynamics; 2011, 32, 2; 55-68
1231-0956
2083-6023
Pojawia się w:
Archives of Thermodynamics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A Predictive Method for the Heat of Explosion of Non-ideal Aluminized Explosives
Autorzy:
Zhang, Q.
Chang, Y.
Powiązania:
https://bibliotekanauki.pl/articles/358737.pdf
Data publikacji:
2013
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
aluminized explosives
heat of explosion
thermodynamic
nonideal explosives
high energy materials
Opis:
The heat of explosion is one of the most important thermodynamic parameters of aluminized explosives. Two improvements in numerical calculations to predict the behaviour of the explosion of non-ideal aluminized explosives were completed in this work. The chemical reaction between aluminum and the C-J detonation products of high energy ingredients was determined and the equation of state for the detonation products of high energy ingredients was revised. The constant k in the BKW equation was revised to obtain perfect results for predicting the C-J parameters for high energy ingredients. The predicted results show that the heats and temperatures of aluminized explosives become maximized when the mass fraction of aluminum powder is 30%, which is in good agreement with the results obtained by empirical formulae.
Źródło:
Central European Journal of Energetic Materials; 2013, 10, 4; 541-554
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A study of transcritical carbon dioxide cycles with heat regeneration
Autorzy:
Trela, M.
Kwidziński, R.
Butrymowicz, D.
Powiązania:
https://bibliotekanauki.pl/articles/239921.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
CO2 thermodynamic cycle
near-critical region
heat regeneration
thermal efficiency
CO2
cykl termodynamiczny
obszar około-krytyczny
regeneracja ciepła
sprawność cieplna
Opis:
The paper presents an efficiency analysis of two transcritical CO2 power cycles with regenerative heaters. For the proposed cycles, calculations of thermal efficiency are given for selected values of operating parameters. It was assumed that the highest working temperature and pressure are in the range from 600 to 700°C and 40 to 50 MPa, respectively. The purpose of the calculations was optimization of the pressure and mass flows in the regenerative heaters to achieve maximum cycle efficiency. It follows that for the assumed upper CO2 parameters, efficiency of 51-54% can be reached, which is comparable to the efficiency of a supercritical advanced power cycle considered by Dostal.
Źródło:
Archives of Thermodynamics; 2013, 34, 3; 197-217
1231-0956
2083-6023
Pojawia się w:
Archives of Thermodynamics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A thermodynamic analysis of a gas-steam turbine incorporating a full model of a spray – ejector condense
Autorzy:
Ziółkowski, P.
Powiązania:
https://bibliotekanauki.pl/articles/175324.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
computational flow mechanics modelling
two-phase ejector
thermodynamic analysis
numerical analysis
Opis:
The specific issues that occur in the mathematical modelling of a spray-ejector condenser have been presented. The results of a thermodynamic analysis of a steam-gas turbine cycle have been obtained by computational flow mechanics code. The main aim of the spray-ejector condenser is simultaneously condensing steam and compressing CO2 from the condensation pressure to about 100 kPa. Hence, the most important innovation of this steam-gas cycle emerges as the enhanced condensation, which is based on the nano-injection of cold water and a jet-powered compression of CO2 performed in the spray-ejector condenser.
Źródło:
Transactions of the Institute of Fluid-Flow Machinery; 2018, 139; 63-96
0079-3205
Pojawia się w:
Transactions of the Institute of Fluid-Flow Machinery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A thermodynamic study on catalytic decomposition of hydrazine in a space thruster
Autorzy:
Pakdehi, Shahram
Shirvani, Fatemeh
Zolfaghari, Reihaneh
Powiązania:
https://bibliotekanauki.pl/articles/240211.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
catalytic thruster
hydrazine
ammonia
specific impulse
thermodynamic
analysis
Opis:
Most satellites stationed in space use catalytic propulsion systems for attitude control and orbit adjustment. Hydrazine is consumed extensively as liquid monopropellant, in the thrusters. Catalytic reactor is the most important section in the catalytic thruster. Ammonia and nitrogen gases are produced as a result of complete catalytic decomposition of hydrazine in the reactor, causing an increase in temperature and a rise in specific impulse. Ammonia is subsequently decomposed, leading to nitrogen and hydrogen gases. Decomposition of ammonia leads to a decrease in temperature, molecular weight and specific impulse. The latter phenomenon is unavoidable. The effect of ammonia decomposition on the reactor temperature, molecular weight of gaseous products and conclusively on specific impulse was studied in this article. At adiabatic state, thermodynamic analysis revealed that the maximum and minimum temperatures were 1655 K and 773 K, respectively. The highest molecular weight was obtained at ammonia conversion of zero and the lowest when ammonia conversion was 100%. The maximum specific impulse (305.4 S) was obtained at ammonia conversion of zero and completely conversion of ammonia, the minimum specific impulse (about 213.7 s) was obtained. For specific impulse, the result of thermodynamic calculation in this work was validated by the empirical results.
Źródło:
Archives of Thermodynamics; 2019, 40, 4; 151-166
1231-0956
2083-6023
Pojawia się w:
Archives of Thermodynamics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Achievement of the charge exchange work diminishing of an internal combustion engine in part load
Uzyskanie zmniejszenia pracy wymiany ładunku przy częściowym obciążeniu silnika spalinowego
Autorzy:
Postrzednik, S.
Żmudka, Z.
Powiązania:
https://bibliotekanauki.pl/articles/375310.pdf
Data publikacji:
2012
Wydawca:
Politechnika Śląska. Wydawnictwo Politechniki Śląskiej
Tematy:
sprawność silnika
obieg termodynamiczny
zawór uruchamiający
obciążenie silnika
silnik spalinowy
engine efficiency
thermodynamic cycle
valve actuating
combustion engine
engine load
Opis:
Internal combustion engines, used for driving of different cars, occurs not only at full load, but mostly at the part load. The relative load exchange work at the full (nominal) engine load is significantly low. At the part load of the IC engine its energy efficiency ηₑ is significantly lower than in the optimal (nominal field) range of the performance parameters. One of the numerous reasons of this effect is regular growing of the relative load exchange work of the IC engine. It is directly connected with the quantitative regulation method commonly used in the IC engines. From the thermodynamic point of view - the main reason of this effect is the throttling process (causing exergy losses) occurring in the inlet and outlet channels. The known proposals for solving of this problem are based on applying of the fully electronic control of the motion of inlet, outlet valves and new reference cycles. The idea presented in the paper leads to diminishing the charge exchange work of the IC engines. The problem can be solved using presented in the paper a new concept of the reference cycle (called as eco-cycle) of IC engine. The work of the engine basing on the eco-cycle occurs in two 3-stroke stages; the fresh air is delivered only once for both stages, but in range of each stage a new portion of fuel is burned. Normally the charge exchange occurs once during each engine cycle realized. Elaborated proposition bases on the elimination of chosen charge exchange processes and through this the dropping of the charge exchange work can be achieved.
Silniki spalinowe, stosowane jako jednostki napędowe samochodów, pracują nie tylko przy pełnym (nominalnym) obciążeniu, ale także (najczęściej) pod obciążeniem częściowym. Względna praca wymiany ładunku silnika przy jego pełnym obciążeniu jest stosunkowo niewielka. Przy obciążeniu częściowym energetyczna sprawność ηₑ silnika spalinowego jest znacznie niższa aniżeli przy jego pełnym (optymalnym) obciążeniu, co między innymi jest powiązane z wielkością pracy wymiany ładunku w układzie. Z termodynamicznego punktu widzenia przyczyną tych zmian jest proces dławienia (przepustnica, straty egzergii) głównie na dopływie do silnika, co jest efektem tzw. ilościowej regulacji silnika spalinowego. Przygotowywane są różne propozycje rozwiązań, prowadzące do efektywnego zmniejszenia pracy wymiany ładunku przy niskich obciążeniach silnika. Jednym z proponowanych prostszych rozwiązań w tym zakresie może być zastosowanie tzw. ekoobiegu, którego idea polega na zmniejszeniu liczby napełnień cylindra. Przedmiotem analizy są możliwości realizacyjne oraz uwarunkowania eksploatacyjne ekoobiegu silnika spalinowego. Zasadniczym warunkiem branym pod uwagę, było kryterium sprawności energetycznej ekoobiegu w stosunku do sprawności istniejących obiegów klasycznych, a w szczególności stwierdzenie możliwości zwiększenia sprawności układu, głównie w zakresie obciążeń częściowych silnika spalinowego. Wskazano na sposób kontroli i dobór warunków spalania w układzie.
Źródło:
Transport Problems; 2012, 7, 1; 63-76
1896-0596
2300-861X
Pojawia się w:
Transport Problems
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acoustical studies of binary liquid mixtures of p-chlorotoluene in benzene at different temperatures
Autorzy:
Kumar, G. P.
Babu, Ch. P.
Samatha, K
Jyosthna, A. N.
Showrilu, K.
Powiązania:
https://bibliotekanauki.pl/articles/412275.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
ultrasonic velocity
thermodynamic parameters
p-chlorotoluene
molecular interactions
Opis:
Ultrasonic velocities (U), densities (ρ), and coefficient of viscosities (η) are measured for binary mixtures containing (i) p-chlorotoluene and (ii) benzene at 303.15 K, 308.15 K, 313.15 K and 318.15 K to understand the molecular interaction. Various acoustical parameters such as adiabatic compressibility (βad), free length (Lf), acoustic impedance (Z), free volume (Vf), molar volume (Vm), Rao’s constant (R), Wada’s constant (W) and internal pressure (πi), are calculated from the measured values of U, ρ, and η. The trend in acoustical parameters also substantiates to asses strong molecular interactions.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 10; 25-37
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adsorption and adsorption isotherm: application to corrosion inhibition studies of mild steel in 2 M HCl
Autorzy:
Abeng, F. E.
Idim, V. D.
Obono, O. E.
Magu, T. O.
Powiązania:
https://bibliotekanauki.pl/articles/1178372.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Adsorption isotherm
inhibition mechanism
mild steel
thermodynamic parameters
Opis:
Ethanollic extract of Phyllanthus amarus (EEPA) was tested as corrosion inhibitor for mild steel in 2 M HCl solution using gravimetric and gasometric methods at 303, 313, 323 K and 333 K. The results revealed that the corrosion rate increases with temperature and time. Addition of the concentration of ethanollic extract of Phyllanthus amarus to the corroding environment lowered the corrosion rate of mild steel and increased inhibition efficiency (IE %) of ethanollic extract. Inhibition efficiency was found to decreased with temperature. Fitting of the experimental data to the Arrhenius and Transition state equations revealed that the Organic constituents of the extract were physically adsorbed on the corroding surface of the steel and adsorption of ethanollic extract of Phyllanthus amarus (EEPA) on mild steel surface was found to obey the Langmuir adsorption isotherm and Freundlich adsorption isotherm and sign of the Gibb’s fee energy of the adsorption obtained suggested that inhibitor molecules have been spontaneously adsorbed onto the mild steel surface. Positive values obtained for enthalpy change indicated that the adsorption of inhibitor is endothermic.
Źródło:
World Scientific News; 2017, 77, 2; 298-313
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adsorption and Thermodynamic Studies for Corrosion Inhibition of API 5L X-52 Steel in 2 M HCl Solution by Moxifloxacin
Autorzy:
Ikpi, M. E.
Abeng, F. E.
Obono, O. E.
Powiązania:
https://bibliotekanauki.pl/articles/1118241.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
API 5L X-52 steel
corrosion inhibition
moxifloxacin and adsorption
thermodynamic
Opis:
The inhibition of API 5L X-52 steel corrosion in an acidic medium by moxifloxacin at 303 K, 313 K and 323 K was monitored by potentiodynamic polarization measurement. The concentration of acid medium was maintained throughout the experiment. The inhibition efficiency was found to increased with increase in concentration of moxifloxacin and temperature. Activation energy, adsorption and thermodynamic parameters were evaluated from the study temperature. Herein, moxifloxacin brought about a decrease in activation energy Ea that reflects chemisorption. The adsorption of the moxifloxacin on the steel surface was found to obeyed Langmuir adsorption isotherm ΔGads values, indicating strong and spontaneous adsorption of the moxifloxacin on the surface of API 5L X-52 steel.
Źródło:
World News of Natural Sciences; 2017, 9; 52-61
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adsorption of CO2 by surface modified coal-based activated carbons: kinetic and thermodynamic analysis
Autorzy:
Xinzhe, Liu
Mingyang, Zhang
Juan, Chen
Zhengyu, Hu
Shuaifei, Xian
Mingxuan, Tang
Chenchen, Zhang
Powiązania:
https://bibliotekanauki.pl/articles/2174813.pdf
Data publikacji:
2022
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
Surface modification
CO2 adsorption capacity
adsorption kinetics
thermodynamic parameters
Opis:
The effects of different surface modifiers on the CO2 adsorption capacity of coal-based activated carbons were studied, and the diffusion behavior, adsorption kinetics and thermodynamic parameters of CO2 in activated car-bons were analyzed. The results show that compared with ethylene glycol, 1,2-propylenediamine and zinc chloride, potassium hydroxide and sodium hydroxide can greatly improve CO2 adsorption capacity. The adsorption rate is faster, and the adsorption capacity is larger, with the maximum CO2 adsorption capacity being 33.54 mL/g. Fick’s law can well describe the diffusion behavior of CO2 in activated carbon. The addition of a surface modifier can increase the diffusion coefficient. The diffusion of CO2 in activated carbon falls into the category of crystal diffusion. The adsorption kinetics of CO2 before and after surface modification follow the Bangham equation. During the adsorption process, δ H < 0, δ G < 0, δ S < 0. Surface modification can reduce adsorption heat and promote adsorption, and the adsorption process is dominated by physisorption.
Źródło:
Polish Journal of Chemical Technology; 2022, 24, 3; 19--28
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Alternative cogeneration thermodynamic cycles for domestic ORC
Autorzy:
Mikielewicz, D.
Wajs, J.
Mikielewicz, J.
Powiązania:
https://bibliotekanauki.pl/articles/185524.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
microcogeneration
thermodynamic cycle
power generation
mikrokogeneracja
cykl termodynamiczny
wytwarzanie energii
Opis:
The Organic Flash Cycle (OFC) is suggested as a vapor power cycle that could potentially improve the efficiency of utilization of the heat source. Low and medium temperature finite thermal sources are considered in the cycle. Additionally the OFC’s aim is to reduce temperature difference during heat addition. The study examines 2 different fluids. Comparisons are drawn between the OFC and an optimized basic Organic Rankine Cycle (ORC). Preliminary results show that ethanol and water are better suited for the ORC and OFC due to higher power output. Results also show that the single flash OFC achieves better efficiencies than the optimized basic ORC. Although the OFC improves the heat addition exergetic efficiency, this advantage was negated by irreversibility introduced during flash evaporation.
Źródło:
Chemical and Process Engineering; 2018, 39, 1; 75--84
0208-6425
2300-1925
Pojawia się w:
Chemical and Process Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Alternatywne wersje ewolucji a problem wszechmocy Boga
The Alternative Versions of Evolution and the Problem of God’s Omnipotence
Autorzy:
Życiński, Józef
Powiązania:
https://bibliotekanauki.pl/articles/2013188.pdf
Data publikacji:
2008
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II. Towarzystwo Naukowe KUL
Tematy:
celowość
determinizm
ewolucja
termodynamika
wszechmoc
zło
determinism
evil
evolution
omnipotence
teleology
thermodynamic
Opis:
The author discusses the question whether an alternative version of cosmological and bio-logical evolution could have been actualized to eliminate negative phenomena specific for evolutionary processes in our universe. Specifically, one tries to answer whether the omnipotent God could have created quite different world with different logical principles and diverse laws of nature. Maybe such a world would be better than our universe regarded by Leibniz as the best of all possible universes. In trying to solve this problem, one has to remember that the process of evolution co-directs the created world to Divine ideals, values, and purposes; it does not, however, destroy by a logic of necessity or by a determinism of events, which would limit the freedom of creation. It does not eliminate pain and it does not change suffering into joy; it only shows the deepest meaning of the struggles thanks to which biological pain manifests its creative role.
Źródło:
Roczniki Filozoficzne; 2008, 56, 1; 363-377
0035-7685
Pojawia się w:
Roczniki Filozoficzne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
AmiRNA Designer - new method of artificial miRNA design
Autorzy:
Mickiewicz, Agnieszka
Rybarczyk, Agnieszka
Sarzynska, Joanna
Figlerowicz, Marek
Blazewicz, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1038843.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
artificial miRNA
RNAi
gene regulation
sequence specific
thermodynamic profiles
Opis:
MicroRNAs (miRNAs) are small non-coding RNAs that have been found in most of the eukaryotic organisms. They are involved in the regulation of gene expression at the post-transcriptional level in a sequence specific manner. MiRNAs are produced from their precursors by Dicer-dependent small RNA biogenesis pathway. Involvement of miRNAs in a wide range of biological processes makes them excellent candidates for studying gene function or for therapeutic applications. For this purpose, different RNA-based gene silencing techniques have been developed. Artificially transformed miRNAs (amiRNAs) targeting one or several genes of interest represent one of such techniques being a potential tool in functional genomics. Here, we present a new approach to amiRNA*design, implemented as AmiRNA Designer software. Our method is based on the thermodynamic analysis of the native miRNA/miRNA* and miRNA/target duplexes. In contrast to the available automated tools, our program allows the user to perform analysis of natural miRNAs for the organism of interest and to create customized constraints for the design stage. It also provides filtering of the amiRNA candidates for the potential off-targets. AmiRNA Designer is freely available at http://www.cs.put.poznan.pl/arybarczyk/AmiRNA/.
Źródło:
Acta Biochimica Polonica; 2016, 63, 1; 71-77
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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