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Wyszukujesz frazę "peroxisome" wg kryterium: Temat

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    Wyświetlanie 1-9 z 9
    Tytuł:
    Pioglitazone, a PPAR-gamma ligand, exerts cytostatic/cytotoxic effects against cancer cells, that do not result from inhibition of proteasome
    Autorzy:
    Mrówka, Piotr
    Głodkowska, Eliza
    Młynarczuk-Biały, Izabela
    Biały, Łukasz
    Kuckelkorn, Ulrike
    Nowis, Dominika
    Makowski, Marcin
    Legat, Magdalena
    Gołąb, Jakub
    Powiązania:
    https://bibliotekanauki.pl/articles/1040817.pdf
    Data publikacji:
    2008
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    peroxisome proliferator-activated receptor-gamma
    thiazolidinediones
    proteasome
    pioglitazone
    Opis:
    Thiazolidinediones are oral antidiabetic agents that activate peroxisome proliferator-activated receptor-gamma (PPAR-γ) and exert potent antioxidant and anti-inflammatory properties. It has also been shown that PPAR-γ agonists induce G0/G1 arrest and apoptosis of malignant cells. Some of these effects have been suggested to result from inhibition of proteasome activity in target cells. The aim of our studies was to critically evaluate the cytostatic/cytotoxic effects of one of thiazolidinediones (pioglitazone) and its influence on proteasome activity. Pioglitazone exerted dose-dependent cytostatic/cytotoxic effects in MIA PaCa-2 cells. Incubation of tumor cells with pioglitazone resulted in increased levels of p53 and p27 and decreased levels of cyclin D1. Accumulation of polyubiquitinated proteins within cells incubated with pioglitazone suggested dysfunction of proteasome activity. However, we did not observe any influence of pioglitazone on the activity of isolated proteasome and on the proteolytic activity in lysates of pioglitazone-treated MIA PaCa-2 cells. Further, treatment with pioglitazone did not cause an accumulation of fluorescent proteasome substrates in transfected HeLa cells expressing unstable GFP variants. Our results indicate that pioglitazone does not act as a direct or indirect proteasome inhibitor.
    Źródło:
    Acta Biochimica Polonica; 2008, 55, 1; 75-84
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Role of NADPH oxidase in the regulation of peroxisome dynamics
    Autorzy:
    Rodriguez-Serrano, M.
    Romero-Puerta, M.
    Sanz-Fernandez, M.
    Cardenas, K.
    Sandalio, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/81177.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    reactive oxygen species
    signalling network
    peroxisome dynamics
    NADPH oxidase
    Arabidopsis
    oxidative stress
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evidence for differential effects of glucose and cycloheximide on mRNA levels of peroxisome proliferator-activated receptor- (PPAR-) machinery members: Superinduction of PPAR-γ1 and -γ2 mRNAs
    Autorzy:
    Rypka, Miroslav
    Veselý, Jaroslav
    Powiązania:
    https://bibliotekanauki.pl/articles/1040405.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    peroxisome proliferator-activated receptor
    HepG2 cells
    mRNA stability
    PPAR-γ coactivator
    superinduction
    Opis:
    Quantitative real-time RT-PCR study was conducted to reveal the effects of normal (5 mmol/l) and high (30 mmol/l) glucose without or with oleate (0.3 mmol/l) on mRNA levels of peroxisome proliferator-activated receptor- (PPAR-)α, -γ1, -γ2, and peroxisome proliferator-activated receptor-γ coactivator- (PGC-)1α and -1β in commercial human hepatoma-derived HepG2 cells maintained under low-serum condition. Significant decrease in PPAR-γ1 and PGC-1α mRNA levels to about 50 % was observed during the first 4 h incubation period. During the next 4 h period, both PPAR-γ1 and PGC-1α mRNAs were partly but significantly restored in high glucose batches. In this period, the presence of the transcriptional inhibitor actinomycin D revealed a significant protective effect of excess glucose on mature PPAR-γ1 and PGC-1α mRNAs. Furthermore, PPAR-γ1 and -γ2 mRNAs were differentially superinduced 1.2-2.5 fold in cells upon the administration of the translational inhibitor cycloheximide. When the cells were co-treated with the combination of cycloheximide and actinomycin D, superinduction was completely suppressed, however. Altogether, the experiments revealed, first, an unexpected protective effect of abundant glucose on PPAR-γ1 and PGC-1α mRNAs in HepG2 cells. Second, we demonstrated cycloheximide-induced, transcription-dependent upregulation of mature PPAR-γ1 and -γ2 mRNAs in HepG2 cells associated with preferential expression of the PPAR-γ2 mRNA variant. The results draw attention to as yet unexplored mechanisms involved in the control of PPAR and PGC genes.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 2; 209-215
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ligands of peroxisome proliferator-activated receptor-γ increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages.
    Autorzy:
    Jozkowicz, Alicja
    Dulak, Jozef
    Piatkowska, Ewa
    Placha, Wojciech
    Dembinska-Kiec, Aldona
    Powiązania:
    https://bibliotekanauki.pl/articles/1044268.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    angiogenesis
    ciglitazone
    vascular endothelial growth factor
    thiazolidinediones
    prostaglandin-J2
    peroxisome proliferator-activated receptor-γ
    Opis:
    Peroxisome proliferator-activated receptors-γ (PPARγ) are ligand-inducible transcription factors of the nuclear hormone receptor superfamily. We examined the effect of PPARγ activation on the generation of vascular endothelial growth factor (VEGF), one of the major angiogenic agents. Rat vascular smooth muscle cells (VSMC) and murine macrophages RAW264.7 were incubated for 24 h with PPARγ activators: prostaglandin J2 and ciglitazone. PPARγ were expressed in VSMC and RAW cells and their activity was upregulated in the presence of PGJ2 and ciglitazone. Incubation of the cells with PPARγ activators significantly augmented the release of VEGF protein into the media, both in resting and in IL-1β- or LPS-stimulated cultures. The higher protein generation was connected with the increased expression of mRNA and transcriptional activation of VEGF promoter. We conclude that the activation of PPARγ upregulates the generation of VEGF and may be involved in the regulation of angiogenesis.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 4; 1147-1157
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Singlet oxygen emerges as a common theme in the plant response to multiple stresses
    Autorzy:
    Mor, A.
    Rosenwasser, S.
    Sibony-Benyamini, H.
    Fluhr, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/80488.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    conference
    oxygen
    multiple stress
    light energy
    photosynthesis
    biotic stress
    abiotic stress
    chlorophyll
    peroxisome
    mitochondrion
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prostaglandin-J2 upregulates expression of matrix metalloproteinase-1 independently of activation of peroxisome proliferator-activated receptor-γ.
    Autorzy:
    Józkowicz, Alicja
    Huk, Ihor
    Nigisch, Anneliese
    Cisowski, Jarosław
    Weigel, Guenter
    Dulak, Józef
    Powiązania:
    https://bibliotekanauki.pl/articles/1043441.pdf
    Data publikacji:
    2003
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    matrix metalloproteinase-1
    urokinase plasminogen activator
    prostaglandin-J2
    peroxisome proliferator-activated receptor-γ
    endothelial cells
    Opis:
    Peroxisome proliferator-activated receptor-γ (PPARγ) is a ligand-inducible nuclear receptor that functions as a transcription factor involved in lipid metabolism, inflammatory response and angiogenesis. The most potent endogenous PPARγ activator is 15-deoxy-Δ12,14prostaglandin-J2 (15d-PGJ2), whereas synthetic ligands include the oral antidiabetic drugs thiazolidinediones (TZDs). Activation of PPARγ was reported to decrease the synthesis of matrix metalloproteinases (MMPs) in vascular smooth muscle cells and macrophages. We aimed to investigate the effect of PPARγ ligands on expression of MMP-1 and urokinase plasminogen activator (uPA) in human microvascular endothelial cells (HMEC-1). We found that treatment of HMEC-1 with 15d-PGJ2 increased the synthesis of MMP-1 protein up to 168% comparing to untreated cells. TZDs (ciglitazone and troglitazone), more potent activators of PPARγ in HMEC-1, did not influence MMP-1 production, arguing against the involvement of PPARγ in this process. Importantly, the stimulatory effect of 15d-PGJ2 was reversed by the antioxidant N-acetyl-cysteine (NAC), suggesting a contribution of oxidative stress. We demonstrated also that 15d-PGJ2 did not change the activity of MMP-1 promoter, but increased the stability of MMP-1 mRNA. In contrast, 15d-PGJ2 very potently inhibited the synthesis of uPA. This effect was in part mimicked by ciglitazone and troglitazone implying an involvement of PPARγ. Accordingly, NAC did not modify the inhibitory effect of 15d-PGJ2 on uPA expression. In conclusion, we postulate that 15d-PGJ2 may differently regulate the synthesis of proteases involved in angiogenesis : it upregulates MMP-1 expression in HMEC-1 through induction of oxidative stress, and inhibits uPA synthesis partly by activation of PPARγ.
    Źródło:
    Acta Biochimica Polonica; 2003, 50, 3; 677-689
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Proliferation of peroxisomes in pea root nodules - an influence of NaCl- or Hg2plus-stress conditions
    Autorzy:
    Borucki, W
    Powiązania:
    https://bibliotekanauki.pl/articles/58800.pdf
    Data publikacji:
    2007
    Wydawca:
    Polskie Towarzystwo Botaniczne
    Tematy:
    proliferation
    peroxisome
    pea
    root nodule
    sodium chloride
    stress condition
    Pisum sativum
    cytochemistry
    catalase activity
    morphometry
    salinity
    mercury treatment
    Opis:
    Morphometric procedures were used to examine peroxisome number and di-stribution in pea (Pisum sativum L.) root nodules under NaCl (50 mM) or HgCl2 (7.3 µM) treatment. Peroxisomes were visualized cytochemically in meristem, invasion zone and prefixing zone of pea root nodules by catalase (EC 1.11.1.6) activity. The observations using light and electron microscopy revealed that the peroxisomes were predominantly spherical in shape and showed catalase activity. In nitrogen fixation zone, catalase active peroxisomes were observed occasionally. Bacteroids of nitrogen fixing zone showed enhanced cata-lase activity probably as a response to higher level of oxidative stress. Fluorescence microscopy investigations revealed enhanced level of (homo)glutathione in prefixing and nitrogen-fixing zone of NaCl- and Hg2+treated nodules, which served as an indicator of antioxidative response. Morphometric measurements revealed that during differentiation of meristematic cells into central tissue (bacteroidal tissue) cells an increase in peroxisome number was observed in unstressed nodules. Peroxisomes located in meristem, invasion zone and prefixing zone of NaCl- and Hg2+-treated nodules outnumbered that in control nodules. A substantial enlargement of peroxisome profiles was detected in NaCl- and Hg2+treated nodules. Peroxisome divisions observed in meristematic and infection thread penetration zone were responsible for an increase in peroxisome number.
    Źródło:
    Acta Societatis Botanicorum Poloniae; 2007, 76, 4; 287-298
    0001-6977
    2083-9480
    Pojawia się w:
    Acta Societatis Botanicorum Poloniae
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Regulation of steroidogenic function of mouse Leydig cells: G-coupled membrane estrogen receptor and peroxisome proliferator-activated receptor partnership
    Autorzy:
    Gorowska-Wojtowicz, E.
    Dutka, P.
    Kudrycka, M.
    Pawlicki, P.
    Milon, A.
    Plachno, B.J.
    Tworzydlo, W.
    Pardyak, L.
    Kaminska, A.
    Hejmej, A.
    Bilinska, B.
    Kotula-Balak, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/70604.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    Leydig cell
    steroidogenic function
    mice
    mouse
    G-coupled membrane estrogen receptor
    peroxisome proliferator-activated receptor
    lutropin
    cholesterol level
    steroidogenesis
    Źródło:
    Journal of Physiology and Pharmacology; 2018, 69, 3
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Agoniści receptorów aktywowanych proliferatorami peroksysomów w farmakoterapii. Obecne znaczenie i perspektywy zastosowania
    Peroxisome proliferator-activated receptor agonists in pharmacotherapy: current status and prospects of usage
    Autorzy:
    Dobrek, Łukasz
    Powiązania:
    https://bibliotekanauki.pl/articles/528024.pdf
    Data publikacji:
    2017
    Wydawca:
    Krakowska Akademia im. Andrzeja Frycza Modrzewskiego
    Tematy:
    receptory aktywowane proliferatorami peroksysomów (PPAR)
    fibraty
    tiazolidinediony
    agoniści PPAR
    peroxisome proliferator activated receptors (PPAR)
    fibrates
    thiazolidinediones
    PPAR agonists
    Opis:
    Receptory aktywowane proliferatorami peroksysomów (ang. peroxisome proliferators- -activated receptors, PPAR), występujące w trzech zasadniczych izoformach (α, β/δ oraz γ), są jądrowymi czynnikami transkrypcyjnymi uczestniczącymi w przemianach metabolicznych lipidów oraz glukozy. Receptory te są punktem uchwytu fi bratów (będących agonistami PPAR-α), stosowanych w farmakoterapii hipertrójglicyrydemii, oraz tiazolidinedionów – glitazonów (wpływających na PPAR-γ) wykorzystywanych jako leki hipoglikemizujące u pacjentów z cukrzycą typu 2. Trwają prace nad nowymi związkami o charakterze podwójnych agonistów receptorów PPAR-α/γ (glitazarów) lub nad związkami wykazującymi agonistyczny wpływ w stosunku do receptorów PPAR-γ oraz błonowych receptorów typu 1 dla wolnych kwasów tłuszczowych FFAR1 (ang. free fatty acid receptors 1). Wpływ na PPAR, wyrażający się właściwościami przeciwzapalnymi, przeciwmiażdżycowymi i przeciwnowotworowymi, wykazują także inne związki, jak statyny, sartany lub niesterydowe leki przeciwzapalne, co poszerza ich dotychczasowy opis farmakodynamiczny. Można zatem stwierdzić, iż agonistyczny wpływ na receptory PPAR jest istotnym elementem mechanizmu działania wielu leków, zarówno tych już stosowanych w farmakoterapii, jak i nowych związków, będących obecnie w fazie badań eksperymentalnych i klinicznych.
    Peroxisome proliferator-activated receptors (PPAR), present in three major isoforms (α, β / δ and γ), are nuclear transcription factors involved in lipid and glucose metabolism. Those receptors are targeted by fi brates (PPAR-α agonists) used in the hypertriglyceridemia and by thiazolidinediones (glitazones, affecting PPAR-γ), used as hypoglycemic agents in the treatment of type 2 diabetes. Furthermore, there is ongoing work on the new double receptor PPAR-α/γ agonists (glitazars) or compounds affecting both PPAR-γ and free fatty acids receptors 1 (FFAR1). The ability to stimulate PPAR, resulted in antiinfl ammatory, anti-atherogenic and anti-proliferative properties, is also demonstrated by other compounds, such as statins, sartans or non-steroidal anti-infl ammatory drugs. The revealed feature broadens their pharmacodynamic description. To sum up, the agonistic effect on PPAR is an important element of the mechanism of action of many pharmacological agents, both drugs already applied in pharmacotherapy, and novel compounds that are currently in experimental studies and clinical trials.
    Źródło:
    Państwo i Społeczeństwo; 2017, 4; 71-87
    1643-8299
    2451-0858
    Pojawia się w:
    Państwo i Społeczeństwo
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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