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Wyświetlanie 1-25 z 138
Tytuł:
Effect of nitric oxide on boar sperm motility, membrane integrity, and acrosomal status during semen storage
Autorzy:
Jovicić, M.
Pintus, E.
Fenclova, T.
Simonik, O.
Chmelikova, E.
Ros-Santaella, J. L.
Sedmikova, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087766.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
boar spermatozoa
nitric oxide
nitric oxide synthases
NO donor
NOS inhibitor
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 1; 73-82
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of oligochitosans on expression of inos gene in ehrlich ascites tumour in vitro
Autorzy:
Ignacak, Jan
Wiśniewska-Wrona, Maria
Dulińska-Litewka, Joanna
Pałka, Iwona
Zagajewski, Jacek
Niekraszewicz, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/1035407.pdf
Data publikacji:
2012
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan oligomers
histone H1
iNOS (inducible nitric oxide synthase)
nitric oxide
Opis:
Oligochitosans obtained through degradation of macromolecules of chitosan with a high degree of deacetylation turned out to be biologically active, contributing to an increase of nitric oxide levels in Ehrlich ascites tumor (EAT) cells through inducing expression of the isoform of inducible nitric oxide synthase (iNOS) gene. An increase of NO levels in EAT cells in the presence of the investigated oligochitosans might contribute to nitrosylation of L-cysteine – an allosteric effector of the M2 isoenzyme of pyruvate kinase (PK), which switches the PK kinase activity, responsible for ATP synthesis, to the histone kinase activity that may participate in histone H1 phosphorylation. Lack of the histone activity of the PK M2 isoenzyme may contribute to decreased histone H1 phosphorylation and thus inhibit EAT cells proliferation.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 141-148
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytotoxic effect of nitric oxide on human hematological malignant cells.
Autorzy:
Tsumori, Michihiro
Tanaka, Junko
Koshimura, Kunio
Kawaguchi, Mikiko
Murakami, Yoshio
Kato, Yuzuru
Powiązania:
https://bibliotekanauki.pl/articles/1043819.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
lymphoma
myeloma
leukemia
nitric oxide
Opis:
We investigated the cytotoxic effect of nitric oxide (NO) on primary culture of human hematological malignant cells. Sodium nitroprusside (SNP), an NO donor, had cytotoxic effects on the cells of some patients with malignant lymphoma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma. Cultured cells from the ML patient remained sensitive to SNP after the cells became resistant to anti-cancer drugs. In contrast, the cells from the patients with AML and CMMoL became resistant to SNP while anti-cancer drugs remained effective. In samples of the cells of the patients with ML and AML, the number of CD3 positive lymphoma cell was decreased by SNP and the number of CD33 negative cells and normal B lymphocytes (CD19 positive cells) were increased. In the cells of the patient with ML, apoptosis was induced by SNP. SNP had no effect on lymphocytes of healthy volunteers. These results suggest that SNP had an anti-tumor effect on human hematological malignant cells.
Źródło:
Acta Biochimica Polonica; 2002, 49, 1; 139-144
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A narrative review on inhaled nitric oxide to treat Coronavirus Disease 2019.
Autorzy:
Romanelli, Antonio
De Rosa, Rosanna Carmela
Powiązania:
https://bibliotekanauki.pl/articles/2054912.pdf
Data publikacji:
2022-06-30
Wydawca:
Towarzystwo Pomocy Doraźnej
Tematy:
COVID-19
cARDS
nitric oxide
Opis:
COVID-19-associated ARDS (cARDS) results from multiple pathogenetic mechanisms involving both parenchyma and circulation of the lungs. Despite authors described two pneumonia phenotypes according to lung elastance values, reported as Low and High phenotype, the evidence suggests that patients with cARDS have similar respiratory mechanics to patients with ARDS from other causes. Consequently, the proper management of patients with cARDS is the same as ARDS,consisting of protective mechanical ventilation strategy and prone position ventilation.However, the hypothesis that impaired alveolar perfusion could have a role in cARDS is interesting. Nitric oxide (NO) is a biatomic gaseous moleculeables to induce smooth muscle relaxation and vasodilation. So, inhaled nitric oxide (iNO) acts as a selective vasodilator because it only dilates vessels in areas participating in gas exchange, preserving hypoxic pulmonary vasoconstriction reflex and reducing ventilation/perfusion mismatch. With this narrative review we summarised the role of iNO for cARDS treatment to improve gas exchange. Furthermore, we briefly described its activity as an antiviral agent. In conclusion, although iNO administration can represent a valid theoretical therapeutic choice for the treatment of severe unresponsive hypoxemia in COVID-19 patients, data presented in the literature are scares and inconclusive, and several clinical trials are still ongoing. Further studies are needed to elucidate the pathogenetic mechanism of respiratory failure related to SARS-CoV-2 infection and inhaled NO role in patients with severe disease.
Źródło:
Critical Care Innovations; 2022, 5, 2; 40-50
2545-2533
Pojawia się w:
Critical Care Innovations
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Receiver operating characteristic analysis of the FeNO biomarker in the diagnosis of asthma
Autorzy:
Biesiadecki, Marek
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/454725.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
asthma
nitric oxide
ROC curve
Opis:
Introduction. The fraction of exhaled nitric oxide (FeNO) is used as a non-invasive biomarker that reflects inflammation in the airways. It is so versatile that it used to control asthma severity as well as to monitor response to treatment. However, the exact cut-off point of the nitric oxide level which allows one to make a precise diagnosis of asthma is unclear. Aim. To examine the possibility of using advanced statistical methods such as receiver operating characteristic for the analysis of FeNO concentrations for improving the diagnosis of asthma. Materials and methods. Receiver operating characteristic (ROC) was used for analyzing results to determine levels of nitric oxide which may be a prognostic indicator of asthma. The studied group consisted of 111 children including 69 asthmatic patients, and 42 age- and sex-matched healthy subjects. Measurement of exhaled nitric oxide was conducted in all subjects included in this study. Results. FeNO level was higher in asthmatic patients. The analysis of results showed that the cut-off point for the FeNO concentration is 11.5 ppb. Sensitivity and specificity with the FeNO level allowed us to determine a value of the diagnostic variable of FeNO concentration of 14.0 ppb. A comparison of FeNO level and sex of the subjects showed there is no correlation between these parameters of patients. Conclusions. Currently, the FeNO measurement provides complementary d
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 4; 253-258
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Histochemical study of the nitric oxide synthase activity in experimental trichinellosis
Autorzy:
Hadas, E.
Gustowska, L.
Boczon, K.
Janczewska, D.
Powiązania:
https://bibliotekanauki.pl/articles/837102.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
nitric oxide synthase
mouse
mice
trichinellosis
enzyme
nitric oxide
Trichinella spiralis
synthase activity
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Allelic polymorphism of endothelial NO-synthase gene and its functional manifestations
Autorzy:
Dosenko, Victor
Zagoriy, Vyacheslav
Haytovich, Nikolay
Gordok, Olga
Moibenko, Alexey
Powiązania:
https://bibliotekanauki.pl/articles/1041240.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
activity of nitric oxide synthase
endothelial nitric oxide synthase
RNA expression
platelets
allelic polymorphism
Opis:
Investigation of the mechanisms of phenotypic realization of allelic polymorphism of the eNOS gene has shown that the level of eNOS mRNA and activity of this enzyme in platelets depends from genotype. We identified a T-786→C polymorphism in the promoter region, a variable number of tandem repeats (4a/4b) in intron 4 and the G894→T polymorphism in exon 7 of the eNOS gene in isolated human platelets. We measured eNOS mRNA in isolated platelets by reverse transcription-PCR and eNOS enzyme activity by fluorimetric detection system FCANOS-1 using diaminofluorescein diacetate (DAF-2A). It was shown that the level of eNOS mRNA is the lowest for the -786C/C promoter genotype. In exon 7 homozygotes (894T/T) the level of RNA is lower than in normal homozygotes (894G/G), but higher than in heterozygotes (894G/T). The eNOS activity in platelets is lower in carriers of the 786C/C promoter genotype than in normal homozygotes (2.1 × P=0.03), and lower comparing to heterozygotes (2.9 × P>0.05). The eNOS activity accompanying the 894T/T variant of exon 7 is also lower than in normal homozygotes (P>0.05). Regarding the polymorphism in intron 4 - the enzyme's activity is lower in carriers of the 4a/4a genotype comparing to normal homozygotes (1.7 × P>0.05) and lower than in heterozygotes (1.9 × P>0.05). These results allow one to conclude that the T-786→C polymorphism of the eNOS gene promoter most significantly affects the gene expression and eNOS activity.
Źródło:
Acta Biochimica Polonica; 2006, 53, 2; 299-302
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gas Transmitters (CO and NO) as Factors Regulating the Skin Cells Functions
Autorzy:
KOZIOROWSKA, ANNA
ROMEROWICZ-MISIELAK, MARIA
Powiązania:
https://bibliotekanauki.pl/articles/455157.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski
Tematy:
Cells viability
Carbon monoxide
Nitric oxide
Opis:
The paper presents the results of research conducted on cells isolated from the epidermal layer of the skin taken from the ear of domestic swine (Sus scrofa). It was checked whether the increase in the concentration of carbon monoxide (CO) in cell culture, cause changes in their viability, and will affect the changes in the production of nitric oxide. For evaluation of the viability of cells, the MTT assay was used. The concentration of a nitric oxide metabolites (NO3/NO2), in the cell supernatants was measured using test-Measure iT High-Sensitivity Nitrite Assay Kit.
Źródło:
Edukacja-Technika-Informatyka; 2017, 8, 1; 131-136
2080-9069
Pojawia się w:
Edukacja-Technika-Informatyka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical evaluation of the influence of L-arginine on biomarkers of environmental (cellular) stress in the kidneys of pregnant female rats
Autorzy:
Pedrycz, Agnieszka
Siermontowski, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/989964.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
nitric oxide
cellular stress
kidneys
pregnancy
immunohistochemistry
Opis:
Introduction. Kidney damage during pregnancy constitutes a diagnostic and therapeutic challenge. However, it is not entirely known whether a kidney condition recognised before the pregnancy releases an organism’s response to pregnancy, or whether pregnancy itself worsens kidney function. Objective. The aim of the study was immunohistochemical evaluation of cells of kidneys of pregnant rats under the influence of nitric oxide (NO), with measurement of the immunoexpression of cellular stress markers (p-53, HSP 70). The dose of administered L-arginine (NO substrate) was approximated to that applied in obstetrics in gestosis prevention and treatment in pregnant women. Materials and method. 60 female rats used in experiment were divided into 6 groups: 3 experimental and 3 control. The females from experimental groups were administered L-arginine (40g/kg, per os) every other day starting from the seventh day or pregnancy. The animals were decapitated on the 10th, 20th day of pregnancy, and 10 days after the delivery. Kidneys taken from decapitated rats were evaluated using the immunohistochemical three step method. HSP 70 and p-53 proteins were detected. Conclusions. L-arginine increased the expression of p-53 protein – on the 10th day of pregnancy, which increased at the end of pregnancy; however, 10 days after delivery the level dropped below that observable during physiological pregnancy. Hormonal changes in physiological pregnancy cause an increase in expression of the p-53 (cell stress marker) in the epithelial cells of renal tubules, mainly at the end of pregnancy (20th day). 10 days after the delivery, this expression decreases. The expression of HSP-70 protein increases already on the 10th day of pregnancy and maintains a similar level throughout the pregnancy, but is reduced after the puerperium.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 1
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical study on the development of cholinergic and nitrergic nerve structures in the bovine esophageal groove
Autorzy:
Marszałek, M.
Serzysko, T.
Sienkiewicz, W.
Powiązania:
https://bibliotekanauki.pl/articles/16539106.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
esophageal groove
acetylcholine
nitric oxide
immunohistochemistry
development
Opis:
The proper functioning of the perinatal sucking reflex in calves is essential for the prevention of milk leakage into the rumen. The complex process behind its regulation is mediated at the gut level via multiple excitatory and inhibitory neurotransmitters, of which acetylcholine and nitric oxide are of fundamental importance. The aim of our study was to depict age-related alterations in the cholinergic and nitrergic innervation of the esophageal groove (EG) using immunohistochemistry and Real-Time PCR methods. We found out that the highest number of cholinergic nerve cells was present in the second trimester fetuses. From this developmental stage onward, their amount was gradually decreasing and reached the lowest value in 4-year-old cows. The same developmental pattern was observed for nitrergic nerve structures with the highest percentage of nitrergic neurons in the third trimester fetuses. Our observations prove that both neuronal populations are crucial for a proper closure of EG in calves. Therefore, their contribution to a general neuronal activity in the ENS diminishes with age as the high motility of a gastric groove is not necessarily required in older cattle.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 1; 165-174
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Relation between nitric oxide (NO) level in semen and certain properties of boar spermatozoa stored at 17°C
Autorzy:
Orzołek, A.
Zasiadczyk, Ł.
Wysocki, P.
Kordan, W.
Krysztofiak, P.
Powiązania:
https://bibliotekanauki.pl/articles/2087744.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
nitric oxide
liquid storage
boar spermatozoa quality
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 2; 423-426
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of thiocetam on the parameters of the nitric oxide system under the conditions of the experimental periodontitis and immobilization stress formation
Autorzy:
Regeda, Mykhailo
Olekshij, Petro
Regeda-Furdychko, Maaryana
Furdychko, Lubomur
Kolishetska, Marta
Regeda, Stepan
Fil, Vitalii
Powiązania:
https://bibliotekanauki.pl/articles/40570860.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
L-arginine
nitric oxide
periodontitis
stress
thiocetam
Opis:
Introduction and aim. The aim of this work is to study the parameters of the nitric oxide (NO) system in the blood of guinea pigs under the conditions of the experimental periodontitis (EP) and immobilization stress (IS) formation and to evaluate the effectiveness of thiocetam use. Material and methods. Experimental studies were performed on 50 guinea pigs (males, body weight 0.18–0.21 kg) which were divided into five groups (10 in each): the first group were intact animals as control; the second experimental group were animals with experimental periodontitis under conditions of immobilization stress (3rd day), the third group included guinea pigs with EP and IS on the 5th day of the combined model process, group IV – animals with EP and IS 15th day (without administration of thiocetam) and group V – animals on the 15th day of experiment with EP and IS after use of thiocetam. Results. As a result of this research, changes in the activity of the NO system in the blood were observed, namely an increase in the level of stable metabolites and an increase in the activity of total NO-synthase, which is accompanied by a compensatory inhibition of the L-arginine activity, and these indicators were most pronounced in the late stages of EP and IS formation. Conclusion. The use of thiocetam showed a corrective effect on the changed variables of NO metabolism in the peripheral blood of guinea pigs under the conditions of the EP and IS development.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 340-346
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nitric oxide and platelet energy metabolism.
Autorzy:
Tomasiak, Marian
Stelmach, Halina
Rusak, Tomasz
Wysocka, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1041559.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mitochondrial energy production
porcine platelets
nitric oxide
glycolysis
Opis:
This study was undertaken to determine whether nitric oxide (NO) can affect platelet responses through the inhibition of energy production. It was found that NO donors: S-nitroso-N-acetylpenicyllamine, SNAP, (5-50 μM) and sodium nitroprusside, SNP, (5-100 μM) inhibited collagen- and ADP-induced aggregation of porcine platelets. The corresponding IC50 values for SNAP and SNP varied from 5 to 30 μM and from 9 to 75 μM, respectively. Collagen- and thrombin-induced platelet secretion was inhibited by SNAP (IC50 = 50 μM) and by SNP (IC50 = 100 μM). SNAP (20-100 μM), SNP (10-200 μM) and collagen (20 μg/ml) stimulated glycolysis in intact platelets. The degree of glycolysis stimulation exerted by NO donors was similar to that produced by respiratory chain inhibitors (cyanide and antimycin A) or uncouplers (2,4-dinitrophenol). Neither the NO donors nor the respiratory chain blockers affected glycolysis in platelet homogenate. SNAP (20-100 μM) and SNP (50-200 μM) inhibited oxygen consumption by platelets. The effect of SNP and SNAP on glycolysis and respiration was not reduced by 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one, a selective inhibitor of NO-stimulated guanylate cyclase. SNAP (5-100 μM) and SNP (10-300 μM) inhibited the activity of platelet cytochrome oxidase and had no effect on NADH:ubiquinone oxidoreductase and succinate dehydrogenase. Blocking of the mitochondrial energy production by antimycin A slightly affected collagen-evoked aggregation and strongly inhibited platelet secretion. The results indicate that: 1) in porcine platelets NO is able to diminish mitochondrial energy production through the inhibition of cytochrome oxidase, 2) the inhibitory effect of NO on platelet secretion (but not aggregation) can be attributed to the reduction of mitochondrial energy production.
Źródło:
Acta Biochimica Polonica; 2004, 51, 3; 789-803
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Monitoring of urine nitric oxide (NO) related substrates and immunological competence in hematological malignancy.
Autorzy:
Tanaka, Junko
Koshimura, Kunio
Tsumori, Michihiro
Murakami, Yoshio
Kato, Yuzuru
Powiązania:
https://bibliotekanauki.pl/articles/1043832.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
pokeweed mitogen
hematological malignancy
urine nitric oxide
phytohemagglutinin
Opis:
It has been reported that concentrations of neopterin in the urine are changed according to the host immunological conditions. In the present study, we measured urinary concentration of neopterin in patients with malignant hematological disorders and investigated the relationship between urinary neopterin levels and laboratory indices for cellular immunity. Urine neopterin levels were correlated with serum sIL-2R levels in the patients with malignant lymphoma, and inversely correlated with lymphocyte reactivity with ConA in the patients with acute myelocytic leukemia. However, no significant correlation was observed between urine neopterin levels and lymphocyte reactivity with phytohemagglutinin and pokeweed mitogen, CD4/8 ratio, CD56+16+ subset or serum IFN-β levels. In the patients with malignant lymphoma, parallel changes in serum sIL-2R and urine neopterin were observed. The presented results suggest that urine neopterin levels are related to the activation of T cells in malignant lymphoma.
Źródło:
Acta Biochimica Polonica; 2002, 49, 1; 227-232
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pilot Plant Studies on Nox Removal Via No Ozonation and Absorption
Badania w skali pilotowej dotyczące efektywności usuwana NOx porzez utlenianie NO i absorpcję
Autorzy:
Kordylewski, W.
Jakubiak, M.
Hardy, T.
Powiązania:
https://bibliotekanauki.pl/articles/205030.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
nitric oxide
ozonation
absorption
tlenek azotu
ozonowanie
absorpcja
Opis:
The results of experimental investigations on the removal of NOx from gases applying ozone as the oxidizing agent and the absorption of higher nitrogen oxides in the sodium hydroxide solutions are presented. The experiment was conducted using a pilot plant installation with the air flow rate 200 m3/h, being a prototype of a boiler flue gas duct and a FGD scrubber. It was shown that in the range of [NOref] = 50 ÷ 250 ppm the mechanism of NO ozonation depends on the molar ratio X = O3/NOref: for X ≤ 1.0 oxidation of NO to NO2 predominates and NO2 is poorly absorbed, for X >> 1.0 NO2 undergoes further oxidation to N2O5, which is efficiently absorbed in the scrubber. The stoichiometric molar ratio of complete conversion of NO into N2O5 is X = 1.5, in these studies to reach the effectiveness η ≥ 90% the molar ratio X was much higher (2.75).
Przedstawiono wyniki badań doświadczalnych dotyczące usuwania NOx z gazów z zastosowaniem ozonu jako utleniacza i absorpcji wyższych tlenków azotu w roztworach wodorotlenku sodu. Badania prowadzono na strumieniu powietrza 200 m3/h w instalacji pilotowej będącej prototypem instalacji kotłowej odprowadzenia spalin i skrubera IOS. Wykazano, że w zakresie [NOref] =50÷250 ppm mechanizm ozonizacji NO zależy od stosunku molowego X = O3/NOref: dla X ≤ 1.0 przeważa utlenianie NO do NO2 a NO2 jest słabo absorbowany, dla X >> 1,0 NO2 ulega dalszemu utlenianiu do N2O5, który jest efektywnie absorbowany w skruberze. Stosunek molowy przy całkowitej konwersji NO do N2O5 wynosi X = 1.5, w przeprowadzonych badaniach, aby osiągnąć efektywność η ≥ 90% stosunek X był dużo większy (2,75).
Źródło:
Archives of Environmental Protection; 2013, 39, 3; 93-106
2083-4772
2083-4810
Pojawia się w:
Archives of Environmental Protection
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Across-shift changes of exhaled nitric oxide and spirometric indices among cotton textile workers
Autorzy:
Mirmohammadi, Seyed J.
Mehrparvar, Amir H.
Safaei, Sara
Nodoushan, Mojahede S.
Jahromi, Mona T.
Powiązania:
https://bibliotekanauki.pl/articles/2178880.pdf
Data publikacji:
2014-10-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
spirometry
across shift
exhaled nitric oxide
textile industry
Opis:
Objectives: For the purpose of evaluation of exhaled NO as an index of airway inflammation, we assessed changes in fractional exhaled NO (FeNO) across a work shift and its relationship with respiratory complaints. Material and Methods: Chronic and work-aggravated respiratory complaints were assessed using a questionnaire in 89 male textile workers. FeNO and spirometry were performed before and after a work shift and all the changes were registered. Results: A significant increase in FeNO after a work shift was observed. Post-shift FeNO was significantly higher among the subjects with chronic respiratory complaints. There was an obvious decrease in FVC, and FEV₁ after a work shift; however, we couldn’t find a significant relationship between changes in respiratory parameters and concentration of inhalable dusts. Conclusions: FeNO increase after a work shift along with pulmonary function decrement and higher post-shift FeNO among subjects with respiratory complaints makes across-shift FeNO a non-invasive test for assessment of airway hyper-responsiveness in textile workers.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2014, 27, 5; 707-715
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymorphism in intron 23 of the endothelial nitric oxide synthase gene (NOS3) is not associated with hypertension.
Autorzy:
Derebecka, Natalia
Hołysz, Marcin
Dankowski, Rafał
Wierzchowski, Michał
Trzeciak, Wiesław
Powiązania:
https://bibliotekanauki.pl/articles/1043838.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
nitric oxide synthase
gene polymorphism
hypertension
intron 23
Opis:
Nitric oxide (NO) is synthesised in the vascular endothelium by nitric oxide synthase (NOS3) and is an important factor in the regulation of blood pressure. Impaired synthesis of NO due to mutations in the NOS3 gene is associated with hypertension. To date several allelic variants of the NOS3 gene have been identified and their possible linkage with hypertension investigated. We studied the distribution of genotypes and frequency of alleles of the G11T polymorphism in intron 23 of the NOS3 gene in patients with hypertension and in a control group of healthy individuals. The polymorphism was determined by PCR-RFLP analysis. The distribution of genotypes in the patients with hypertension and in the healthy individuals did not differ significantly from the values predicted from Hardy-Weinberg equilibrium for the general population. No major differences in the distribution of the G11T polymorphism in the patients and healthy individuals were found (P > 0.05).
Źródło:
Acta Biochimica Polonica; 2002, 49, 1; 263-268
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mitochondria recycle nitrite back to the bioregulator nitric monoxide.
Autorzy:
Nohl, Hans
Staniek, Katrin
Sobhian, Babak
Bahrami, Soheyl
Redl, Heinz
Kozlov, Andrey
Powiązania:
https://bibliotekanauki.pl/articles/1044210.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
nitrite reductase
electron paramagnetic resonance
nitric oxide
mitochondria
Opis:
Nitric monoxide (NO) exerts a great variety of physiological functions. L-Arginine supplies amino groups which are transformed to NO in various NO-synthase-active isoenzyme complexes. NO-synthesis is stimulated under various conditions increasing the tissue of stable NO-metabolites. The major oxidation product found is nitrite. Elevated nitrite levels were reported to exist in a variety of diseases including HIV, reperfusion injury and hypovolemic shock. Denitrifying bacteria such as Paracoccus denitrificans have a membrane bound set of cytochromes (cyt cd1, cyt bc) which were shown to be involved in nitrite reduction activities. Mammalian mitochondria have similar cytochromes which form part of the respiratory chain. Like in bacteria quinols are used as reductants of these types of cytochromes. The observation of one-e- divergence from this redox-couple to external dioxygen made us to study whether this site of the respiratory chain may also recycle nitrite back to its bioactive form NO. Thus, the aim of the present study was therefore to confirm the existence of a reductive pathway which reestablishes the existence of the bioregulator NO from its main metabolite NO2-. Our results show that respiring mitochondria readily reduce added nitrite to NO which was made visible by nitrosylation of deoxyhemoglobin. The adduct gives characteristic triplet-ESR-signals. Using inhibitors of the respiratory chain for chemical sequestration of respiratory segments we were able to identify the site where nitrite is reduced. The results confirm the ubiquinone/cyt bc1 couple as the reductant site where nitrite is recycled. The high affinity of NO to the heme-iron of cytochrome oxidase will result in an impairment of mitochondrial energy-production. "Nitrite tolerance" of angina pectoris patients using NO-donors may be explained in that way.
Źródło:
Acta Biochimica Polonica; 2000, 47, 4; 913-921
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carboxyebselen a potent and selective inhibitor of endothelial nitric oxide synthase
Autorzy:
Hatchett, R J
Gryglewski, R.J.
Mlochowski, J.
Zembowicz, A.
Radziszewski, W.
Powiązania:
https://bibliotekanauki.pl/articles/70733.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
carboxyebselen
nitric oxide
L-arginine
endothelium
inhibitor
ebselen
Źródło:
Journal of Physiology and Pharmacology; 1994, 45, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of hyperbaric exposure on vascular endothelium’s capability of nitric oxide synthesis
Wpływ ekspozycji hiperbarycznej na zdolność śródbłonka naczyń do syntezy tlenku azotu
Autorzy:
Kozakiewicz, M.
Kaczerska, D.
Ciesielska, N.
Powiązania:
https://bibliotekanauki.pl/articles/366666.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
Tematy:
nitric oxide
endothelium
hyperbaric oxygenation
tlenek azotu
śródbłonek
hiperbaria
Opis:
The paper presents an aphonia of the effects of hyperbaric exposures on endothelial capability to generate nitric oxide synthesis, expressed as a measurement of the concentration of nitrates/nitrites in the blood serum of volunteers subjected to a hyperbaric exposure. In addition the method of measurement of total concentration of superoxides was used to assess the impact of antioxidant capacity while being subjected to hyperbaric oxygenation. Results: A significantly higher concentration of nitrates/nitrites was observed following a hyperbaric exposure. Similarly, an increased concentration of total superoxides in the researched groups was observed. Conclusions: The obtained results indicate that staying in a hyperbaric environment is not insignificant for endothelial cells. However, the issue that stays open is the one concerning the time and the pressure conditions in which the exposure remains safe.
Praca przedstawia alalię wpływu ekspozycji hiperbarycznych na zdolność śródbłonka naczyń do syntezy tlenku azotu wyrażoną jako pomiar stężenia azotanów/azotynów w surowicy ochotników poddanych ekspozycji hiperbarycznej. Dodatkowo oceniano za pomocą pomiaru stężenia całkowitego stężenia ponadtlenków jaki wpływ na pojemność antyoksydacyjną ma przebywanie w hiperbarii. Wyniki: Zaobserwowano istotnie wyższe stężenie azotanów/azotynów po ekspozycji hiperbarycznej. Podobnie zaobserwowano podwyższone stężenie całkowitego stężenia nadtlenków w badanej grupie. Wnioski: Uzyskane wyniki pokazują, że przebywanie w środowisku hiperbarycznym nie jest obojętne dla komórek śródbłonka. Otwartym pozostaje jednak problem jaki czas i na jakie warunki ciśnieniowe pozostaje bezpieczny.
Źródło:
Polish Hyperbaric Research; 2013, 4(45); 7-18
1734-7009
2084-0535
Pojawia się w:
Polish Hyperbaric Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Generation of nitric oxide from nitrovasodilator modulates the release of histamine from mast cells
Autorzy:
Masini, E
Di Bello, M.G.
Pistelli, A.
Raspanti, S.
Gambassi, F.
Mugnai, L.
Lupini, M.
Mannaioni, P.F.
Powiązania:
https://bibliotekanauki.pl/articles/70323.pdf
Data publikacji:
1994
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
nitrovasodilator
histamine
mast cell
nitric oxide
histamine release
rat
Źródło:
Journal of Physiology and Pharmacology; 1994, 45, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rola argininy w organizmie człowieka
The role of the arginine in the human body
Autorzy:
Zdrojewicz, Zygmunt
Winiarski, Jacek
Popowicz, Ewa
Szyca, Marta
Śmieszniak, Bartłomiej
Michalik, Tomasz
Buczko, Klaudia
Powiązania:
https://bibliotekanauki.pl/articles/1114561.pdf
Data publikacji:
2019
Wydawca:
Collegium Witelona Uczelnia Państwowa
Tematy:
arginina
wątroba
tlenek azotu
doping
arginine
liver
nitric oxide
Opis:
Celem niniejszego opracowania jest przedstawienie roli argininy w organizmie człowieka. Arginina jest aminokwasem względnie egzogennym, co oznacza, że pomimo tego, iż jest produkowana w ludzkim ciele, to dostarczanie jej wraz z pożywieniem jest równie ważne dla zachowania homeostazy organizmu. Główne źródło argininy w diecie stanowią mięso i owoce morza. Aminokwas ten jest syntezowany w czasie cyklu mocznikowego w wątrobie, a także w nerkach. Bierze udział między innymi w wytwarzaniu tlenku azotu, który jest czynnikiem rozszerzającym naczynia. Liczne prace wskazują również na skuteczność suplementacji argininą w zaburzeniach erekcji. Udział argininy w tej reakcji przyczynił się do zainteresowania wielu badaczy. Dowiedziono, że oprócz powszechnie znanego zastosowania argininy jako leku wspomagającego wątrobę w usuwaniu z organizmu amoniaku, odpowiednia suplementacja tego aminokwasu ma pozytywny wpływ na poprawę wartości ciśnienia tętniczego indukowanego ciążą, nadciśnienia płucnego oraz wyrównanie niewydolności nerek, cukrzycy, jaskry, gojenia się ran i profilaktykę udarów mózgu. Uważa się, że stężenie argininy wpływa na rozwój chorób neurodegeneracyjnych postępujących z wiekiem. Aminokwas ten jest też środkiem chętnie stosowanym przez sportowców w celu poprawienia wydolności organizmu. Jednak przeprowadzone do tej pory badania nie potwierdzają jego pozytywnego wpływu w tym zakresie.
Źródło:
Zeszyty Naukowe Państwowej Wyższej Szkoły Zawodowej im. Witelona w Legnicy; 2019, 1, 30; 163-171
1896-8333
Pojawia się w:
Zeszyty Naukowe Państwowej Wyższej Szkoły Zawodowej im. Witelona w Legnicy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pilot-scale studies on NOx removal from flue gas via NO ozonation and absorption into NaOH solution
Autorzy:
Jakubiak, M.P.
Kordylewski, W.K.
Powiązania:
https://bibliotekanauki.pl/articles/185772.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
tlenek azotu
ozonowanie
absorpcja
ozonation
absorption
nitric oxide
deNOx
Opis:
The paper presents results of experimental studies on removal of NOx from flue gas via NO ozonation and wet scrubbing of products of NO oxidation in NaOH solutions. The experiment was conducted in a pilot plant installation supplied with flue gas from a coal-fired boiler at the flow rate 200 m3/h. The initial mole fraction of NOx,ref in flue gas was approx. 220 ppm, the molar ratio X = O3/NOref varied between 0 and 2.5. Ozone (O3 content 1-5% in oxygen) was injected into the flue gas channel before the wet scrubber. The effect of the mole ratio X, the NaOH concentration in the absorbent, the liquid-to-gas ratio (L/G) and the initial NOx concentration on the efficiency of NOx removal was examined. Two domains of the molar ratio X were distinguished in which denitrification was governed by different mechanisms: for X > 1.0 NO2 undergoes further oxidation to higher oxides being efficiently absorbed in the scrubber. At the stoichiometric conditions (X = 1) the effectiveness of NO oxidation was better than 90%. However, the effectiveness of NOx removal reached only 25%. When ozonation was intensified (X >/= 2.25) about 95% of NOx was removed from flue gas. The concentration of sodium hydroxide in the aqueous solution and the liquid-to-gas ratio in the absorber had little effect on the effectiveness of NOx removal for X > 2.
Źródło:
Chemical and Process Engineering; 2012, 33, 3; 345-358
0208-6425
2300-1925
Pojawia się w:
Chemical and Process Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exhaled nitric oxide in smokers and former smokers with chronic obstructive pulmonary disease
Autorzy:
Galiniak, S.
Aebisher, D.
Rachel, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087917.pdf
Data publikacji:
2020
Wydawca:
Uniwersytet Opolski. Instytut Nauk o Zdrowiu
Tematy:
nitric oxide
smoking
respiratory diseases
chronic obstructive pulmonary disease
Opis:
Background: Measurement of fractional exhaled nitric oxide (FeNO) is a useful technique for detection of eosinophilic airway inflammation and assessment of efficiency of corticosteroid treatment in patents with respiratory disease. Generally studies agree that measurement of FeNO is a useful non-invasive biomarker in patients with chronic obstructive pulmonary disease (COPD), however, there are reports that do not confirm such a relationship between FeNO and COPD. Aim of the study: The main objective of this study was to investigate FeNO levels in Polish patients with COPD compared to healthy controls. As a secondary objective, we assessed the influence of smoking on FeNO levels in healthy patients, and patients with COPD. Material and methods: FeNO concentration was measured using an electrochemical analyzer in healthy nonsmokers (n=21), healthy smokers (n=25), and former smokers with COPD (n=30) and smokers with COPD (n=38). General characteristics, hematological variables and serum biochemical parameters were also obtained and analyzed using the Kruskal-Wallis test. Results: FeNO measurement revealed significantly reduced NO levels in healthy smokers compared to healthy non-smokers, former smokers with COPD and smokers with COPD (median [range]: 14 [6–17] vs. 21 [15–29], 25 [15–53], and 19 [11–32] ppb, respectively, p<0.001). Moreover, we found increased FeNO levels in ex-smokers with COPD compared with smokers with COPD (p<0.05). No associations between FeNO and other analyzed parameters were found. Conclusions: Levels of FeNO, measured by with an electrochemical analyzer, were elevated among patients with COPD compared to healthy non-smoking controls. Moreover, our study confirms that smoking results in a reduction in FeNO concentration in both healthy patients and patients with COPD.
Źródło:
Medical Science Pulse; 2020, 14, 2; 36-43
2544-1558
2544-1620
Pojawia się w:
Medical Science Pulse
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exogenous nitric oxide inhibits shedding of ADAM17 substrates
Autorzy:
Bzowska, Monika
Stalińska, Krystyna
Mężyk-Kopeć, Renata
Wawro, Karolina
Duda, Katarzyna
Das, Sudipta
Bereta, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1040593.pdf
Data publikacji:
2009
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
shedding
ADAM17
TNF receptor 1
TNF
nitric oxide
Opis:
Both ADAM17, the secretase responsible for the shedding of ectodomains of numerous membrane proteins including TNF and its receptors, as well as nitric oxide synthesized by inducible nitric oxide synthase play regulatory roles in inflammation and tumor progression. We analyzed the effect of endogenous and exogenous nitric oxide on the expression and activity of ADAM17 in murine endothelial cells and a monocyte/macrophage cell line. We found that endogenous nitric oxide influenced neither ADAM17 mRNA level nor the shedding of two ADAM17 substrates, TNF and TNFR1. Exogenous NO significantly diminished the release of TNF and TNFR1 without affecting the ADAM17 transcript level. Our data seem contrary to a previous report that showed the activation of ADAM17 by nitric oxide (Zhang et al., 2000, J Biol Chem 275: 15839-15844). We discuss potential mechanisms of NO-mediated inhibition of ectodomain shedding and possible reasons of discrepancy between our results and the previous report.
Źródło:
Acta Biochimica Polonica; 2009, 56, 2; 325-335
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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