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Wyświetlanie 1-10 z 138
Tytuł:
Effect of nitric oxide on boar sperm motility, membrane integrity, and acrosomal status during semen storage
Autorzy:
Jovicić, M.
Pintus, E.
Fenclova, T.
Simonik, O.
Chmelikova, E.
Ros-Santaella, J. L.
Sedmikova, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087766.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
boar spermatozoa
nitric oxide
nitric oxide synthases
NO donor
NOS inhibitor
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 1; 73-82
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of oligochitosans on expression of inos gene in ehrlich ascites tumour in vitro
Autorzy:
Ignacak, Jan
Wiśniewska-Wrona, Maria
Dulińska-Litewka, Joanna
Pałka, Iwona
Zagajewski, Jacek
Niekraszewicz, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/1035407.pdf
Data publikacji:
2012
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan oligomers
histone H1
iNOS (inducible nitric oxide synthase)
nitric oxide
Opis:
Oligochitosans obtained through degradation of macromolecules of chitosan with a high degree of deacetylation turned out to be biologically active, contributing to an increase of nitric oxide levels in Ehrlich ascites tumor (EAT) cells through inducing expression of the isoform of inducible nitric oxide synthase (iNOS) gene. An increase of NO levels in EAT cells in the presence of the investigated oligochitosans might contribute to nitrosylation of L-cysteine – an allosteric effector of the M2 isoenzyme of pyruvate kinase (PK), which switches the PK kinase activity, responsible for ATP synthesis, to the histone kinase activity that may participate in histone H1 phosphorylation. Lack of the histone activity of the PK M2 isoenzyme may contribute to decreased histone H1 phosphorylation and thus inhibit EAT cells proliferation.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 141-148
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytotoxic effect of nitric oxide on human hematological malignant cells.
Autorzy:
Tsumori, Michihiro
Tanaka, Junko
Koshimura, Kunio
Kawaguchi, Mikiko
Murakami, Yoshio
Kato, Yuzuru
Powiązania:
https://bibliotekanauki.pl/articles/1043819.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
lymphoma
myeloma
leukemia
nitric oxide
Opis:
We investigated the cytotoxic effect of nitric oxide (NO) on primary culture of human hematological malignant cells. Sodium nitroprusside (SNP), an NO donor, had cytotoxic effects on the cells of some patients with malignant lymphoma (ML), acute myelocytic leukemia (AML) or chronic myelomonocytic leukemia (CMMoL), but not with multiple myeloma. Cultured cells from the ML patient remained sensitive to SNP after the cells became resistant to anti-cancer drugs. In contrast, the cells from the patients with AML and CMMoL became resistant to SNP while anti-cancer drugs remained effective. In samples of the cells of the patients with ML and AML, the number of CD3 positive lymphoma cell was decreased by SNP and the number of CD33 negative cells and normal B lymphocytes (CD19 positive cells) were increased. In the cells of the patient with ML, apoptosis was induced by SNP. SNP had no effect on lymphocytes of healthy volunteers. These results suggest that SNP had an anti-tumor effect on human hematological malignant cells.
Źródło:
Acta Biochimica Polonica; 2002, 49, 1; 139-144
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A narrative review on inhaled nitric oxide to treat Coronavirus Disease 2019.
Autorzy:
Romanelli, Antonio
De Rosa, Rosanna Carmela
Powiązania:
https://bibliotekanauki.pl/articles/2054912.pdf
Data publikacji:
2022-06-30
Wydawca:
Towarzystwo Pomocy Doraźnej
Tematy:
COVID-19
cARDS
nitric oxide
Opis:
COVID-19-associated ARDS (cARDS) results from multiple pathogenetic mechanisms involving both parenchyma and circulation of the lungs. Despite authors described two pneumonia phenotypes according to lung elastance values, reported as Low and High phenotype, the evidence suggests that patients with cARDS have similar respiratory mechanics to patients with ARDS from other causes. Consequently, the proper management of patients with cARDS is the same as ARDS,consisting of protective mechanical ventilation strategy and prone position ventilation.However, the hypothesis that impaired alveolar perfusion could have a role in cARDS is interesting. Nitric oxide (NO) is a biatomic gaseous moleculeables to induce smooth muscle relaxation and vasodilation. So, inhaled nitric oxide (iNO) acts as a selective vasodilator because it only dilates vessels in areas participating in gas exchange, preserving hypoxic pulmonary vasoconstriction reflex and reducing ventilation/perfusion mismatch. With this narrative review we summarised the role of iNO for cARDS treatment to improve gas exchange. Furthermore, we briefly described its activity as an antiviral agent. In conclusion, although iNO administration can represent a valid theoretical therapeutic choice for the treatment of severe unresponsive hypoxemia in COVID-19 patients, data presented in the literature are scares and inconclusive, and several clinical trials are still ongoing. Further studies are needed to elucidate the pathogenetic mechanism of respiratory failure related to SARS-CoV-2 infection and inhaled NO role in patients with severe disease.
Źródło:
Critical Care Innovations; 2022, 5, 2; 40-50
2545-2533
Pojawia się w:
Critical Care Innovations
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Receiver operating characteristic analysis of the FeNO biomarker in the diagnosis of asthma
Autorzy:
Biesiadecki, Marek
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/454725.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
asthma
nitric oxide
ROC curve
Opis:
Introduction. The fraction of exhaled nitric oxide (FeNO) is used as a non-invasive biomarker that reflects inflammation in the airways. It is so versatile that it used to control asthma severity as well as to monitor response to treatment. However, the exact cut-off point of the nitric oxide level which allows one to make a precise diagnosis of asthma is unclear. Aim. To examine the possibility of using advanced statistical methods such as receiver operating characteristic for the analysis of FeNO concentrations for improving the diagnosis of asthma. Materials and methods. Receiver operating characteristic (ROC) was used for analyzing results to determine levels of nitric oxide which may be a prognostic indicator of asthma. The studied group consisted of 111 children including 69 asthmatic patients, and 42 age- and sex-matched healthy subjects. Measurement of exhaled nitric oxide was conducted in all subjects included in this study. Results. FeNO level was higher in asthmatic patients. The analysis of results showed that the cut-off point for the FeNO concentration is 11.5 ppb. Sensitivity and specificity with the FeNO level allowed us to determine a value of the diagnostic variable of FeNO concentration of 14.0 ppb. A comparison of FeNO level and sex of the subjects showed there is no correlation between these parameters of patients. Conclusions. Currently, the FeNO measurement provides complementary d
Źródło:
European Journal of Clinical and Experimental Medicine; 2018, 4; 253-258
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Histochemical study of the nitric oxide synthase activity in experimental trichinellosis
Autorzy:
Hadas, E.
Gustowska, L.
Boczon, K.
Janczewska, D.
Powiązania:
https://bibliotekanauki.pl/articles/837102.pdf
Data publikacji:
1998
Wydawca:
Polskie Towarzystwo Parazytologiczne
Tematy:
parasite
nitric oxide synthase
mouse
mice
trichinellosis
enzyme
nitric oxide
Trichinella spiralis
synthase activity
Źródło:
Annals of Parasitology; 1998, 44, 3
0043-5163
Pojawia się w:
Annals of Parasitology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Allelic polymorphism of endothelial NO-synthase gene and its functional manifestations
Autorzy:
Dosenko, Victor
Zagoriy, Vyacheslav
Haytovich, Nikolay
Gordok, Olga
Moibenko, Alexey
Powiązania:
https://bibliotekanauki.pl/articles/1041240.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
activity of nitric oxide synthase
endothelial nitric oxide synthase
RNA expression
platelets
allelic polymorphism
Opis:
Investigation of the mechanisms of phenotypic realization of allelic polymorphism of the eNOS gene has shown that the level of eNOS mRNA and activity of this enzyme in platelets depends from genotype. We identified a T-786→C polymorphism in the promoter region, a variable number of tandem repeats (4a/4b) in intron 4 and the G894→T polymorphism in exon 7 of the eNOS gene in isolated human platelets. We measured eNOS mRNA in isolated platelets by reverse transcription-PCR and eNOS enzyme activity by fluorimetric detection system FCANOS-1 using diaminofluorescein diacetate (DAF-2A). It was shown that the level of eNOS mRNA is the lowest for the -786C/C promoter genotype. In exon 7 homozygotes (894T/T) the level of RNA is lower than in normal homozygotes (894G/G), but higher than in heterozygotes (894G/T). The eNOS activity in platelets is lower in carriers of the 786C/C promoter genotype than in normal homozygotes (2.1 × P=0.03), and lower comparing to heterozygotes (2.9 × P>0.05). The eNOS activity accompanying the 894T/T variant of exon 7 is also lower than in normal homozygotes (P>0.05). Regarding the polymorphism in intron 4 - the enzyme's activity is lower in carriers of the 4a/4a genotype comparing to normal homozygotes (1.7 × P>0.05) and lower than in heterozygotes (1.9 × P>0.05). These results allow one to conclude that the T-786→C polymorphism of the eNOS gene promoter most significantly affects the gene expression and eNOS activity.
Źródło:
Acta Biochimica Polonica; 2006, 53, 2; 299-302
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gas Transmitters (CO and NO) as Factors Regulating the Skin Cells Functions
Autorzy:
KOZIOROWSKA, ANNA
ROMEROWICZ-MISIELAK, MARIA
Powiązania:
https://bibliotekanauki.pl/articles/455157.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski
Tematy:
Cells viability
Carbon monoxide
Nitric oxide
Opis:
The paper presents the results of research conducted on cells isolated from the epidermal layer of the skin taken from the ear of domestic swine (Sus scrofa). It was checked whether the increase in the concentration of carbon monoxide (CO) in cell culture, cause changes in their viability, and will affect the changes in the production of nitric oxide. For evaluation of the viability of cells, the MTT assay was used. The concentration of a nitric oxide metabolites (NO3/NO2), in the cell supernatants was measured using test-Measure iT High-Sensitivity Nitrite Assay Kit.
Źródło:
Edukacja-Technika-Informatyka; 2017, 8, 1; 131-136
2080-9069
Pojawia się w:
Edukacja-Technika-Informatyka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical evaluation of the influence of L-arginine on biomarkers of environmental (cellular) stress in the kidneys of pregnant female rats
Autorzy:
Pedrycz, Agnieszka
Siermontowski, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/989964.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
nitric oxide
cellular stress
kidneys
pregnancy
immunohistochemistry
Opis:
Introduction. Kidney damage during pregnancy constitutes a diagnostic and therapeutic challenge. However, it is not entirely known whether a kidney condition recognised before the pregnancy releases an organism’s response to pregnancy, or whether pregnancy itself worsens kidney function. Objective. The aim of the study was immunohistochemical evaluation of cells of kidneys of pregnant rats under the influence of nitric oxide (NO), with measurement of the immunoexpression of cellular stress markers (p-53, HSP 70). The dose of administered L-arginine (NO substrate) was approximated to that applied in obstetrics in gestosis prevention and treatment in pregnant women. Materials and method. 60 female rats used in experiment were divided into 6 groups: 3 experimental and 3 control. The females from experimental groups were administered L-arginine (40g/kg, per os) every other day starting from the seventh day or pregnancy. The animals were decapitated on the 10th, 20th day of pregnancy, and 10 days after the delivery. Kidneys taken from decapitated rats were evaluated using the immunohistochemical three step method. HSP 70 and p-53 proteins were detected. Conclusions. L-arginine increased the expression of p-53 protein – on the 10th day of pregnancy, which increased at the end of pregnancy; however, 10 days after delivery the level dropped below that observable during physiological pregnancy. Hormonal changes in physiological pregnancy cause an increase in expression of the p-53 (cell stress marker) in the epithelial cells of renal tubules, mainly at the end of pregnancy (20th day). 10 days after the delivery, this expression decreases. The expression of HSP-70 protein increases already on the 10th day of pregnancy and maintains a similar level throughout the pregnancy, but is reduced after the puerperium.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 1
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical study on the development of cholinergic and nitrergic nerve structures in the bovine esophageal groove
Autorzy:
Marszałek, M.
Serzysko, T.
Sienkiewicz, W.
Powiązania:
https://bibliotekanauki.pl/articles/16539106.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
esophageal groove
acetylcholine
nitric oxide
immunohistochemistry
development
Opis:
The proper functioning of the perinatal sucking reflex in calves is essential for the prevention of milk leakage into the rumen. The complex process behind its regulation is mediated at the gut level via multiple excitatory and inhibitory neurotransmitters, of which acetylcholine and nitric oxide are of fundamental importance. The aim of our study was to depict age-related alterations in the cholinergic and nitrergic innervation of the esophageal groove (EG) using immunohistochemistry and Real-Time PCR methods. We found out that the highest number of cholinergic nerve cells was present in the second trimester fetuses. From this developmental stage onward, their amount was gradually decreasing and reached the lowest value in 4-year-old cows. The same developmental pattern was observed for nitrergic nerve structures with the highest percentage of nitrergic neurons in the third trimester fetuses. Our observations prove that both neuronal populations are crucial for a proper closure of EG in calves. Therefore, their contribution to a general neuronal activity in the ENS diminishes with age as the high motility of a gastric groove is not necessarily required in older cattle.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 1; 165-174
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 138

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