- Tytuł:
- Selected pharmaceutical properties of thermosensitive hydrophilic gels with hydroxypropylmethylcellulose containing lactic acid complexed with chitosan
- Autorzy:
- Małolepsza-Jarmołowska, Katarzyna
- Powiązania:
- https://bibliotekanauki.pl/articles/1035213.pdf
- Data publikacji:
- 2013
- Wydawca:
- Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
- Tematy:
-
1
2- propylene glycol
glycerol
hydroxypropylmethylcellulose
lactic acid complexed with chitosan
thermosensitive polymer - poloxamer 407
vaginal infections - Opis:
- Gels containing lactic acid complexed with chitosan at a stoichiometric ration 1:1 and 2:1 and 5-25% content of polyoxyethylene glycol 200 are able to move from 25 to 30 cm. The addition of 4% hydroxypropylmethylcellulose besides glycerol increases the movability gels containing lactic acid complexed with chitosan in a stoichiometric ration 1:1 from 25 cm to 28 cm and at 2:1 ratio from 27 cm to 30 cm. Higher concentrations of the poloxamer 407: 23 and 25% result in the movability of 24 to 29 cm The addition of 5-25% glycerol decreases the pH of investigated gels from 3.95 to 4.45 (1:1) and from 3.63 to 4.30 (2:1). The addition of 5-25% 1,2-propylene glycol decreases the pH of investigated gels from 4.00 to 4.46 (1:1) and from 3.70 to 4.33 (2:1). The use of hydroxypropylmethylcellulose allowed to obtain physiological range. The addition of hydroxypropylmethylcellulose reduces the pH and maintains high adhesion.
- Źródło:
-
Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 131-138
1896-5644 - Pojawia się w:
- Progress on Chemistry and Application of Chitin and its Derivatives
- Dostawca treści:
- Biblioteka Nauki
Artykuł