Temat: gut microbiota - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Impact of biological treatment on intestinal microbiom in children with Crohn’s disease
Autorzy:: Krawczyk, Agnieszka
Sroka-Oleksiak, Agnieszka
Kowalska-Duplaga, Kinga
Fyderek, Krzysztof
Gosiewski, Tomasz
Salamon, Dominika
Powiązania:: https://bibliotekanauki.pl/articles/1177355.pdf
Data publikacji:: 2018
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: Crohn’s disease
biological treatment
children
gut microbiota
Opis:: Crohn’s disease (CD) is a chronic, inflammatory illness of the digestive tract, characterized by alternating periods of remission and recurrence. The pathogenesis of CD is still unclear but probably is a result of a complex interaction between immunological, genetic and microbiological disorders. In recent years, there has been an increasing extent of evidence that gut microbiota plays a very important role in the pathogenesis of CD. Currently, the most effective treatment is biological therapy using anti-TNF monoclonal antibodies. It is interesting whether biological drugs resulting in fast remission, contributes to the normalization of the gut microbiota. Due to the fact that the children’s population is a significant percentage of all patients with CD, it is important to pay close attention to the problem of microbiological disorders in this age group. The aim of this study was to investigate whether there are quantitative changes of chosen bacteria species and fungi of the genus Candida in children with Crohn's disease relative to healthy children and assesment of quantitative changes in patients after biological treatment. In the group of children with Crohn’s disease, the numbers in Candida were significantly higher (9.74×1017 CFU/g) than in the control group (9.35×1010 CFU/g, p = 0.011). Biological therapy led to a significant reduction in the amount Candida (5.91×1011) and was comparable with the number in the control group. In the case of bacteria, we observed an increase in S. marcescens (3,4×108) in the patients group compared to the controls (1,85×108) and an increase in L. fermentum (2,34×1010) in relation to healthy children (3,31×108, p = 0,048) Biological treatment had an impact on the decrease in L. fermentum (4,76×109, p = 0.05).
Źródło:: World Scientific News; 2018, 104; 245-256
2392-2192
Pojawia się w:: World Scientific News
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Gut microbiome as a biomarker of cardiometabolic disorders
Autorzy:: Gózd-Barszczewska, Anna
Kozioł-Montewka, Maria
Barszczewski, Piotr
Młodzińska, Agata
Humińska, Kinga
Powiązania:: https://bibliotekanauki.pl/articles/991115.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: gut microbiota
atherosclerosis
lipid disorders
microbiome
cardiovascular diseases
Opis:: Introduction and objective. Cardiovascular diseases are the leading cause of death in Europe and worldwide. One of the most important risk factors for atherosclerosis are lipid metabolism disorders, in particular hipercholesterolaemia. The aim of the study was to determine the correlation between gut microbiota composition and atherosclerosis risk factors, so in order that it might be used as a biomarker for coronary artery disease diagnosis. Material and method. The study involved middle-aged men in eastern Poland with central obesity (n=20), subjects with atherosclerosis (n=15) and those with no cardiovascular diseases (n=5). The gut microbiota composition was determined using tag-encoded 16S rRNA gene using Illuminal MiSeq. Data were analyzed with the use of t-test. Results. Firmicutes (49.26%) and Bacteroidetes (44.46%) were the dominant Phyla in the middle-aged men in eastern Poland. Subjects with improper levels of total cholesterol were enriched in Prevotella (p=0.03) and decreased level of Clostridium (p=0.02). They also showed a falling tendency in Faecalibacterium (p=0.07). An upward trend was observed in Prevotella (p=0.07) in subjects with improper LDL-C values. Conclusions. The study showed that intestinal microbiome is likely to play a role in the pathogenesis of atherosclerosis through its role in lipid metabolism. Bacterial genera of particular importance were Prevotella, Bacteroides, Clostridium, Faecalibacterium. However, further studies involving larger groups of subjects are required to confirm these observations.
Źródło:: Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Role of gut microbiota in pathogenesis of selected chronic diseases
Autorzy:: Krawczyk, Agnieszka
Salamon, Dominika
Gosiewski, Tomasz
Powiązania:: https://bibliotekanauki.pl/articles/1065421.pdf
Data publikacji:: 2019
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: autoimmune disease
gut microbiota
immune system response
metabolic disease
Opis:: The human digestive system is colonized by a huge number of microorganisms, that are referred to collectively as the gut microbiota. The composition of intestinal microorganisms are shaped from an early life and undergoes constant changes depending on the influence of external factors, such as: type of delivery, feeding the young child, diet in subsequent years of life, pharmaceuticals use, stress, lifestyle or infections and previous inflammation within the digestive tract. Despite transient changes in microbiota composition, the intestinal ecosystem is constantly striving to maintain homeostasis, both qualitative and quantitative, which is fundamental to human health and human development. Microbes present in the intestines are responsible for sealing the intestinal barrier, mucin production, stimulation of the angiogenesis process, supporting digestive processes by fermentation and decomposition of undigested food residues, vitamin production or protection from pathogenic microorganisms. As shown by numerous studies carried out in recent years, intestinal dysbiosis plays a fundamental role in the development of many chronic diseases such as inflammatory bowel disease, diabetes, obesity, celiac disease, connective tissue diseases and others. Insightful understanding of the interactions between microorganisms and the host organisms can provide new information about pathogenesis of diseases as well as new ways to prevent and treat intestinal or systemic disorders. The aim of this work is to review the latest reports on the role of the gastrointestinal microbiome in selected chronic diseases.
Źródło:: World Scientific News; 2019, 132; 132-154
2392-2192
Pojawia się w:: World Scientific News
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: The role of probiotic intervention in regulating gut microbiota, short-chain fatty acids and depression-like behavior in lead-exposed rats
Autorzy:: Chen, Xiaojun
Meng, Shujuan
Yu, Yongli
Li, Shuang
Wu, Lei
Zhang, Yanshu
Powiązania:: https://bibliotekanauki.pl/articles/2085714.pdf
Data publikacji:: 2022-02-15
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: depression
lead exposure
probiotic
gut microbiota
SCFAs
neurobehavioral tests
Opis:: ObjectivesThe aim of this study was to observe the depression-like behavior changes of rats exposed to lead with or without probiotic intervention, and to investigate changes in the gut microbiota and fecal short-chain fatty acids (SCFAs) levels after lead exposure, and the possible functions of probiotics in this process.Material and MethodsAdult male Sprague Dawley rats were exposed to a 300 mg/l lead acetate solution for 24 weeks, with or without probiotic (freeze-dried powder containing Lactobacillus and Bifidobacterium: 6 billion live bacteria/2 g) intervention in weeks 17–24. The sucrose preference test (SPT), the forced swim test (FST), and the tail suspension test (TST) were preformed to study the depression-like behaviors of these rats. The alteration of rat gut microbiota induced by lead exposure was analyzed by 16S rRNA sequencing, and the levels of fecal SCFAs were detected using gas chromatography.ResultsNeurobehavioral tests showed that lead exposure induced depression-like behavior in rats, including reduced sucrose preference in the SPT, and increased immobility times in the FST and the TST. Sequencing and gas chromatography showed that lead exposure changed the structure and the phylogenetic diversity of the gut microbiota, as well as significantly altered the levels of SCFAs. Moreover, the depression-like behaviors, and the changes in both gut microbiota and SCFAs, could be mitigated by probiotic intervention.ConclusionsLead exposure not only changes the structure and diversity of the gut microbiome but also affects metabolic function. Probiotic intervention may be a novel initiative for the prevention and treatment of neurological damage following lead exposure. Health. 2022;35(1):95–106
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2022, 35, 1; 95-106
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Clinical and microbiological aspects of the use of Lactobacillus rhamnosus PL1 strains in proctological patients with symptoms of chronic proctitis
Autorzy:: Borycka-Kiciak, K
Strus, M
Pietrzak, P
Wawiernia, K
Mikołajczyk, D
Gałęcka, M
Heczko, P
Tarnowski, W
Powiązania:: https://bibliotekanauki.pl/articles/1393584.pdf
Data publikacji:: 2017
Wydawca:: Index Copernicus International
Tematy:: hemorrhoidal disease
diverticulosis
probiotics
gut microbiota
Lactobacillus rhamnosus PL1
Opis:: Recurrent proctitis and the symptoms associated therewith pose significant clinical problem in proctological patients. The objective of this study was to assess the impact of the probiotic Lactobacillus rhamnosus PL1 strain on the clinical presentation and composition of intestinal microbiota in patients with symptoms of proctitis in the course of hemorrhoidal disease and diverticulosis. Material consisted of 24 patients in whom no complete clinical improvement could be obtained after the treatment of the underlying disease. Subject to the assessment was the presence and the intensity of clinical symptoms as well as qualitative and quantitative changes in the composition of bacterial flora detected in the stool before, during and after a 9-week supplementation with the probiotic Lactobacillus rhamnosus PL1 strain. Results: In the entire study group, the intensity of pain after 12 weeks was significantly lower (p=0,.011) compared to baseline; the intensity of flatulence and abdominal discomfort was reduced significantly as early as after 3 weeks, with the difference reaching a highly significant level after 12 weeks (pP<0,.0001). No significant difference was observed in the frequency of the reported episodes of diarrhea, constipation, as well as itching and burning in the anal region. As early as after 3 weeks of supplementation with the probiotic L. rhamnosus PL1 strain, significant qualitative and quantitative changes were observed in the composition of intestinal microbiota; the changes differed depending on the underlying disease. An increase in the total counts of the bacteria of Lactobacillus genus, particularly L. rhamnosus PL1 strain was observed regardless of the underlying disease. Conclusion: Tthe probiotic Lactobacillus rhamnosus PL1 strain appears to be useful in restoring appropriate ratios of bacterial populations in patients presenting with symptoms of proctitis in the course of the treatment of certain diseases of the lower gastrointestinal tract.
Źródło:: Polish Journal of Surgery; 2017, 89, 3; 16-22
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Prebiotyki w żywieniu psów
Prebiotics in dog nutrition
Autorzy:: Mirowski, Adam
Powiązania:: https://bibliotekanauki.pl/articles/22180983.pdf
Data publikacji:: 2021
Wydawca:: Krajowa Izba Lekarsko-Weterynaryjna
Tematy:: psy
suplementy diety
prebiotyki
mikrobiota jelitowa
żywienie zwierząt
oddziaływanie na organizm
nutrition
prebiotic
gut microbiota
dog
Opis:: Microbiological processes in the gastrointestinal tract have great impact on overall animal health. Prebiotic constituents modulate composition and activity of intestinal microflora. Various substances are produced by microorganisms inhabiting large intestine. Short-chain fatty acids are one of the most important end-products of prebiotic fermentation. Prebiotics can improve effectiveness of probiotic supplementation. Some prebiotic substances have also immunomodulatory properties. The aim of this paper was to present the aspects connected with prebiotics in dog nutrition.
Źródło:: Życie Weterynaryjne; 2021, 96, 07; 499-501
0137-6810
Pojawia się w:: Życie Weterynaryjne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Kwas masłowy i maślan – znaczenie biologiczne i zastosowania terapeutyczne
Butyric acid and butyrate – biological significance and therapeutic applications
Autorzy:: Zielińska, Agnieszka
Powiązania:: https://bibliotekanauki.pl/articles/22651747.pdf
Data publikacji:: 2023-12-18
Wydawca:: Wydawnictwo Naukowe Medyk sp. z o.o.
Tematy:: kwas masłowy
maślan sodu
schorzenia jelita grubego
błonnik pokarmowy
flora bakteryjna
butyric acid
sodium butyrate
diseases of the large intestine
dietary fibre
gut microbiota
Opis:: Kwas masłowy jest krótkołańcuchowym kwasem tłuszczowym, wytwarzanym w organizmie ludzkim w wyniku fermentacji mikrobiologicznej w jelicie grubym. Służy nie tylko jako podstawowy składnik odżywczy, który dostarcza energię do kolonocytów, ale także jako mediator komórkowy regulujący wiele funkcji komórek jelitowych, w tym ekspresję genów, różnicowanie komórek, rozwój tkanki jelitowej, redukcję stresu oksydacyjnego i utrzymanie integralności bariery jelitowej. Na produkcję kwasu wpływ ma rodzaj pożywienia oraz zmiany mikroflory jelitowej. Preparaty zawierające sól kwasu (maślan) stosowane są jako środki spożywcze specjalnego przeznaczenia żywieniowego do postępowania dietetycznego u pacjentów z chorobami i zaburzeniami funkcji jelit. Podawane są w przypadku schorzeń takich jak zespół jelita drażliwego (IBS), nieswoiste choroby zapalne jelit, zaburzenia czynnościowe przewodu pokarmowego, biegunki oraz w stanach po radioterapii i zabiegach chirurgicznych dolnego odcinka przewodu pokarmowego.
Butyric acid is a short-chain fatty acid produced in the human body as a result of microbial fermentation in the large intestine. It serves not only as a primary nutrient that provides energy to colonocytes, but also as a cellular mediator regulating many intestinal cell functions, including gene expression, cell differentiation, development of intestinal tissue, reduction of oxidative stress, and maintenance of intestinal barrier integrity. Acid production is influenced by the type of food and changes in the gut microbiota. Medical products containing the salt of the acid (butyrate) are used for particular nutritional uses for the dietary management of patients with diseases and disorders of intestinal function. They are administered in the case of diseases such as irritable bowel syndrome (IBS), inflammatory bowel diseases, functional disorders of the gastrointestinal tract, diarrhea and in conditions after radiotherapy and surgical procedures of the lower gastrointestinal tract.
Źródło:: Lek w Polsce; 2023, 390, 11; 16-20
2353-8597
Pojawia się w:: Lek w Polsce
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Pharmacological properties of fireweed (Epilobium angustifolium L.) and bioavailability of ellagitannins. A review
Autorzy:: Dreger, M.
Adamczak, A.
Seidler-Łożykowska, K.
Wielgus, K.
Powiązania:: https://bibliotekanauki.pl/articles/2049057.pdf
Data publikacji:: 2020
Wydawca:: Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:: rosebay willowherb
pharmacology
bioavailability
benign prostatic hyperplasia (BPH)
oenothein B
urolithins
gut microbiota
wierzbówka kiprzyca
farmakologia
biodostępność
oenoteina B
urolityny
mikroflora jelitowa
łagodny rozrost prostaty (BPH)
Opis:: Fireweed (Epilobium angustifolium L.) is a well-known medicinal plant traditionally used in the treatment of urogenital diseases, stomach and liver disorders, skin problems, etc. E. angustifolium extracts show antiandrogenic, antiproliferative, cytotoxic, antioxidant, anti-inflammatory, immunomodulatory, and antimicrobial activities. The unique combination of biological properties demonstrated by the results of some studies indicates that fireweed has a positive effect in benign prostatic hyperplasia (BPH) and potentially in the prostate cancer chemoprevention. However, the efficacy of E. angustifolium phytotherapy is still poorly tested in clinical trials, while numerous beneficial effects of extracts have been documented in the in vitro and in vivo tests. Fireweed is rich in polyphenolic compounds, particularly ellagitannins. Currently, polyphenols are considered to be modulators of beneficial gut microbiota. The literature data support the use of ellagitannins in the prostate cancer chemoprevention, but caution is advised due to the highly variable production of urolithins by the individual microbiota. A better understanding of the microbiota’s role and the mechanisms of its action are crucial for an optimal therapeutic effect. This paper aims to summarize and discuss experimental data concerning pharmacological properties of E. angustifolium and bioavailability of ellagitannins – important bioactive compounds of this plant.
Źródło:: Herba Polonica; 2020, 66, 1; 52-64
0018-0599
Pojawia się w:: Herba Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: The guide through brain-gut-enteric microbiota axis – regulation pathways and related disorders
Autorzy:: Kolasińska, Karolina
Kwiatkowski, Stanisław
Knap, Bartosz
Czerwiński, Grzegorz
Poniewierka, Elżbieta
Waszczuk, Ewa
Powiązania:: https://bibliotekanauki.pl/articles/1163424.pdf
Data publikacji:: 2018
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: brain-gut axis
enteric microbiota
gastrointestinal system
Opis:: The brain-gut axis is a complex system of connections between the central nervous system (CNS) and the digestive tract. Information within the axis is transmitted through many pathways (neural, endocrine, metabolic, immunological) and is strongly dependent on the microbiota inhabiting the gut. Therefore, the brain-gut axis is also called the “brain-gut-enteric microbiota axis”. Many studies are carried out to determine how it functions but the exact mechanism is still poorly understood. Unraveling the mystery of brain-gut-enteric microbiota axis seems to be crucial in understanding of many diseases and processes governing the human body.
Źródło:: World Scientific News; 2018, 109; 115-130
2392-2192
Pojawia się w:: World Scientific News
Dostawca treści:: Biblioteka Nauki

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