Temat: glutamate receptor - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Screening of chromosomal region 21q22.3 for mutations in genes associated with neuronal Ca2+ signalling in bipolar affective disorder
Autorzy:: Kostyrko, Andrzej
Hauser, Joanna
Rybakowski, Janusz
Trzeciak, Wiesław
Powiązania:: https://bibliotekanauki.pl/articles/1041245.pdf
Data publikacji:: 2006
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: TRPM2 protein
AMPA glutamate receptor B
bipolar affective disorder
Opis:: The therapeutic effect of lithium in bipolar affective disorder may be connected with decreasing intracellular Ca2+ concentrations. Several linkage studies have identified a potential bipolar affective disorder susceptibility locus within chromosomal region 21q22.3. This locus contains two genes expressed in the brain - ADARB1 and TRPM2 - involved in regulating intracellular Ca2+ concentrations. The aim of this study was an identification of mutations in the coding sequences of ADARB1 and TRPM2 and their association with bipolar affective disorder. For that purpose we screened 60 patients with bipolar affective disorder and a control group of 66 subjects using single strand conformation polymorphism and sequence analysis. For rapid screening we performed restriction fragment length polymorphism analysis. Screening of bipolar affective disorder patients for mutations in TRPM2 led to identification of three novel and four known transitions. Two transitions resulted in the substitutions: R755C and A890V. Screening of the coding sequence of ADARB1 did not reveal any mutations except one already known transition. A comparison of the transition frequency in patients and controls does not support association of the detected mutations with bipolar affective disorder. According to our results, bipolar affective disorder may not be caused by mutations in ADARB1. However, this study does not exclude TRPM2 as a candidate gene since we have screened only about 30 per cent of the entire coding sequence of this large gene.
Źródło:: Acta Biochimica Polonica; 2006, 53, 2; 317-320
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Biorational control of arthropod pests with emphasis on the use of the chitin synthesis inhibitor novaluron
Autorzy:: Ishaaya, I.
Lebedev, G.
Ghanim, M.
Horowitz, A.R.
Powiązania:: https://bibliotekanauki.pl/articles/55215.pdf
Data publikacji:: 2011
Wydawca:: Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:: biorational control
arthropod
pest
chitin synthesis
novaluron
insecticide
insect
growth regulator
buprofezin
diflubenzuron
chlorfluazuron
pyriproxyfen
tebufenozide
methoxyphenozide
neonicotinoid
imidacloprid
acetamiprid
thiamethoxam
glutamate receptor
gamma-aminobutyric acid
abamectin
Spinosad preparation
novel insecticide
Opis:: Efforts have been made during the past three decades to develop insecticides with selective properties that act specifically on biochemical sites present in a particular insect group, but whose properties differ from those present in mammals. This approach has led to the discovery of compounds that affect the hormonal regulation of molting and developmental processes in insects such as ecdysone agonists, juvenile hormone (JH) mimics and chitin synthesis inhibitors. The search for potent acylureas has led to the development of novaluron (Rimon) developed by Makhteshim Chemical Works. The LC-50 value of novaluron on 3rd-instar Spodoptera littoralis fed on treated leaves is approximately 0.1 mg a.i./liter. This value resembles that of chlorfluazuron and is tenfold lower than that of teflubenzuron. Novaluron affects nymphs of Bemisia tabaci more than chlorfluazuron and teflubenzuron. Artificial rain, at a rate of 40 mm/h applied 5 and 24 h after treatment in a cotton field had no appreciable effect on the potency of novaluron on both S. littoralis larvae and B. tabaci nymphs. Hence, novaluron can be used in tropical areas and during rainy seasons. In general, benzoylphenyl ureas had no direct effect on parasitoids and phytoseiids and are considered mildly affect other natural enemies. Novaluron has no cross-resistance with conventional insecticides, the JH mimics pyriproxyfen and neonicotinoids. As such, it is considered an important compound in pest management programs.
Źródło:: Pestycydy; 2011, 1-4
0208-8703
Pojawia się w:: Pestycydy
Dostawca treści:: Biblioteka Nauki