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Tytuł:
Apalutamide as a therapeutic option in case of local failure in the nmCRPC
Autorzy:
Stankiewicz, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/22676730.pdf
Data publikacji:
2023-04-01
Wydawca:
Medical Education
Tematy:
prostate cancer
castration resistance
apalutamide
Opis:
Apalutamide is a non-steroidal selective androgen receptor inhibitor approved for the treatment of high-risk non-metastatic castration-resistant prostate cancer and metastatic hormone-sensitive prostate cancer. The paper describes a case of a patient diagnosed with prostate cancer with a long-term course of the disease. The patient was diagnosed with a non-metastatic castration-resistant stage 18 years after primary treatment. Systemic treatment with apalutamide was recommended. Initially, the treatment was carried out as part of the extended access to apalutamide program and from March 2022 as part of the B.56 drug program. The study presents the effectiveness and safety of the therapy in a 12-month follow-up period and discusses controversial aspects of the patient's previous treatments.
Źródło:
OncoReview; 2023, 13, 1; 13-19
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
From Castration to Misogyny. Meaning of Liudprand of Cremona’s Humour
Autorzy:
Grabowski, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/601359.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Instytut Historii im. Tadeusza Manteuffla PAN w Warszawie
Tematy:
gender
sex
violence
nudity
castration
humour
Opis:
Liudprand of Cremona is one of the most interesting authors of the tenth century. He is well known for his description of the Byzantine court and also for his jokes in Antapodosis – a first chronicle of Europe. Based on these tales, he is treated by scholars as a prime example of medieval misogyny. Lately the more political view of these narrations emerged, but still women in Liudprand’s works are seen mainly as victims. This essay shows that this view is wrong and that there is much more to be found in the text. Through Liudprand’s jokes emerges a much more complicated view of the position and role of woman in the society. To see this, the stories have to be put in the context of the tenth-century society.
Źródło:
Acta Poloniae Historica; 2015, 112
0001-6829
Pojawia się w:
Acta Poloniae Historica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Apalutamide treatment of locally advanced prostate cancer
Autorzy:
Palasik, Maria
Powiązania:
https://bibliotekanauki.pl/articles/22676859.pdf
Data publikacji:
2023-03-31
Wydawca:
Medical Education
Tematy:
prostate cancer
castration resistance
hormonotherapy
apalutamide
Opis:
Prostate cancer is most commonly diagnosed cancer in men. The choice of treatment method depends on many factors: the patient’s age, other patient’s diseases, psychophysical status and expected survival time. Hormonotherapy plays very important role in patients with no possible radical treatment. New therapies apply in patients with castration-resistant metastatic prostate cancer. First registered drug in patients with biochemical progression without metastases is apalutamide.
Źródło:
OncoReview; 2023, 13, 1; 31-32
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Apalutamide in the treatment of a patient with non-metastatic castration-resistant prostate cancer
Autorzy:
Dziura, Robert
Powiązania:
https://bibliotekanauki.pl/articles/22676763.pdf
Data publikacji:
2023-03-31
Wydawca:
Medical Education
Tematy:
prostate cancer
castration-resistant
androgen receptor inhibitor
Opis:
The treatment of patients with prostate cancer, who do not qualify for the radical therapy is based on the use of surgical or pharmacological castration methods. The effectiveness of the so-called androgen deprivation tends to decrease over time. Even in the absence of distant metastases on imaging studies, the resistance for the hormonal castration may be developed. At this moment, the use of new generation androgen receptor inhibitors may reduce the risk of metastases or death. The paper presents a case report of a patient with prostate cancer without distant metastases who started therapy with apalutamide at the moment of developing re-sistance to the pharmacological castration.
Źródło:
OncoReview; 2023, 13, 1; 20-23
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Apalutamide as a new option for postponing metastatic disease in hormone -resistant patients with biochemical recurrence in prostate cancer
Autorzy:
Dąbek, Bartosz
Powiązania:
https://bibliotekanauki.pl/articles/22676825.pdf
Data publikacji:
2023-04-04
Wydawca:
Medical Education
Tematy:
non-metastatic castration-resistant prostate cancer
apalutamide
Opis:
Treatment of non-metastatic castration-resistant prostate cancer is a radically new option for cancer patients. Novel anti-hormonal therapy not only improves metastasis free survival but overall survival times and positively impacts quality of life. This case shows how apalutamide lowered tPSA level and postponed metastatic disease.
Źródło:
OncoReview; 2023, 13, 1; 24-26
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A novel orchiectomy surgical procedure in donkeys (Equus asinus africanus) with parascrotal access
Autorzy:
Barrêto JR, R.A.
Rodrigues, L.A.
Albuquerque, J.P.
de Sousa, F.J.A.
Firmino, P.R.
Sousa, R.S.
Pedrosa, V.J.
do Amaral, T.R.
Minervino, A.H.H.
Powiązania:
https://bibliotekanauki.pl/articles/16539181.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
inflammation
donkeys
peritoneal fluid
surgical approach
castration
Opis:
Donkeys are a public health concern in the Northeast region of Brazil, with thousands of stray animals. Orchiectomy is an important population control measure; however, the long postoperative period with daily treatment of open wounds in the scrotum makes it difficult to perform a large number of castrations in sheltering centers. We evaluate a novel surgical procedure for orchiectomy in donkeys using parascrotal access. Twelve donkeys were used, divided into two groups: I - submitted to orchiectomy through parascrotal surgical access (novel procedure), and II - submitted to orchiectomy through scrotal access (conventional). Postoperative evaluations consisted of a macroscopic evaluation of the surgical wound (bleeding and intensity of edema), hematological parameters, and peritoneal fluid, which occurred in both groups at the moments (M): M0 - before the surgical procedure. The others moments occurred after surgery: M12 (twelve hours); M24 (twenty-four hours); M48 (forty-eight hours); M72 (seventy-two hours); M8D (eight days); and M16D (sixteen days). The surgical techniques did not generate an important systemic inflammatory response to the point detected by the leukogram, fibrinogen dosage, and peritoneal fluid. The parascrotal technique required long surgery but promoted less bleeding, less edema, and faster healing. The techniques used did not promote sufficient systemic inflammation to alter the number of leukocytes and the fibrinogen concentration; however, evaluation of the peritoneal fluid proved to be important for evaluating inflammatory processes involving the scrotum and inguinal canal. We describe a novel surgical procedure for orchiectomy in Donkeys using a parascrotal access that promoted less risk of bleeding, shorter period of edema, and healing time, but required longer surgery time.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 2; 295-302
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cardiovascular complications during the treatment of castration-resistant prostate cancer with the use of modern antiandrogens: abiraterone acetate and enzalutamide
Autorzy:
Grabysa, Radosław
Chmielewska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/2047222.pdf
Data publikacji:
2021-09-13
Wydawca:
Medical Education
Tematy:
abiraterone acetate
enzalutamide
castration resistant prostate cancer
cardiovascular
Opis:
Modern antiandrogens: abiraterone acetate (inhibitor of CYP17 cytochrome) and enzalutamide (irreversible inhibitor of androgen receptor) are the drugs that are increasingly often administered in treatment of castration-resistant prostate cancer. Despite their clinical efficacy, especially in terms of prolonged survival and improved quality of life of patients, they pose of problem for a practicing oncologist such as possible cardiovascular complications (particularly arterial hypertension), which may lead to the cessation of this form of therapy. This article provides a brief overview of the mechanisms responsible for the above complications, including practical recommendations in the event such complications arise. A simple scheme of action for control of cardiovascular risk factors has been presented, which can improve the prognosis in this population of patients.
Źródło:
OncoReview; 2021, 11, 3; 61-67
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Apalutamide in the treatment of non-metastatic castration-resistant prostate cancer in an elderly patient with multiple comorbidities
Autorzy:
Liśkiewicz, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/22676727.pdf
Data publikacji:
2023-03-30
Wydawca:
Medical Education
Tematy:
non-metastatic castration-resistant prostatic cancer
androgen receptor
apalutamide
Opis:
Prostate cancer has been the most common malignant tumor in men in Poland since 2016 and is the second cause of death in this group of patients. The basic method of treatment in patients with advanced prostate cancer is androgen deprivation therapy, however, over time, the tumor evolves into a castration-resistant form, which poses a significant threat to the patient's life. This article presents a case of an elderly patient with internal diseases, who in the castration-resistant stage, was treated with a new generation androgen receptor blocker – apalutamide – in the first line of systemic treatment.
Źródło:
OncoReview; 2023, 13, 1; 9-12
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Benedict Hesse’s Teaching on Conjugal Abstinence
Autorzy:
Ozorowski, Mieczysław
Powiązania:
https://bibliotekanauki.pl/articles/2149958.pdf
Data publikacji:
2021
Wydawca:
Uniwersytet w Białymstoku. Wydawnictwo Uniwersytetu w Białymstoku
Tematy:
Benedict Hesse
conjugal chastity
conjugal abstinence
virginity
castration
spousal dress
Opis:
This article focuses on conjugal abstinence in the teaching of the great Polish theologian, Benedict Hesse, who lived and worked in Cracow during the fifteenth century. In his work Commentary on the Gospel of St. Matthew, Hesse focuses his discussion on chastity and conjugal abstinence in the context of several other subjects, including: the superiority of virginity over marriage; the superiority of virginal chastity over conjugal abstinence; the issue of assessing the pleasure of conjugal sexual intercourse; matters pertaining to modesty of the spouses and their exterior appearance; as well as castration for the Kingdom of Heaven. The issues that Hesse raises in relation to chastity and conjugal abstinence might bring a smile to a contemporary reader’s face, since they seem mostly anecdotal and basic. This article is not a complete and systematic lecture on conjugal abstinence.
Źródło:
Rocznik Teologii Katolickiej; 2021, 20; 49-71
1644-8855
Pojawia się w:
Rocznik Teologii Katolickiej
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prostate cancer in clinical practice. First experiences with apalutamide within the context of therapeutic program B.56
Autorzy:
Trzebiński, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/22676841.pdf
Data publikacji:
2023-04-01
Wydawca:
Medical Education
Tematy:
non-metastatic castration-resistant prostate cancer
apalutamide
androgen receptor inhibitor
Opis:
The article contains a case report of patient diagnosed with castration-resistant non-metastatic prostate cancer, treated with a novel androgen receptor inhibitor – apalutamide.
Źródło:
OncoReview; 2023, 13, 1; 27-30
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 15

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