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    Wyświetlanie 1-15 z 15
    Tytuł:
    Apalutamide as a therapeutic option in case of local failure in the nmCRPC
    Autorzy:
    Stankiewicz, Magdalena
    Powiązania:
    https://bibliotekanauki.pl/articles/22676730.pdf
    Data publikacji:
    2023-04-01
    Wydawca:
    Medical Education
    Tematy:
    prostate cancer
    castration resistance
    apalutamide
    Opis:
    Apalutamide is a non-steroidal selective androgen receptor inhibitor approved for the treatment of high-risk non-metastatic castration-resistant prostate cancer and metastatic hormone-sensitive prostate cancer. The paper describes a case of a patient diagnosed with prostate cancer with a long-term course of the disease. The patient was diagnosed with a non-metastatic castration-resistant stage 18 years after primary treatment. Systemic treatment with apalutamide was recommended. Initially, the treatment was carried out as part of the extended access to apalutamide program and from March 2022 as part of the B.56 drug program. The study presents the effectiveness and safety of the therapy in a 12-month follow-up period and discusses controversial aspects of the patient's previous treatments.
    Źródło:
    OncoReview; 2023, 13, 1; 13-19
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Apalutamide treatment of locally advanced prostate cancer
    Autorzy:
    Palasik, Maria
    Powiązania:
    https://bibliotekanauki.pl/articles/22676859.pdf
    Data publikacji:
    2023-03-31
    Wydawca:
    Medical Education
    Tematy:
    prostate cancer
    castration resistance
    hormonotherapy
    apalutamide
    Opis:
    Prostate cancer is most commonly diagnosed cancer in men. The choice of treatment method depends on many factors: the patient’s age, other patient’s diseases, psychophysical status and expected survival time. Hormonotherapy plays very important role in patients with no possible radical treatment. New therapies apply in patients with castration-resistant metastatic prostate cancer. First registered drug in patients with biochemical progression without metastases is apalutamide.
    Źródło:
    OncoReview; 2023, 13, 1; 31-32
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    From Castration to Misogyny. Meaning of Liudprand of Cremona’s Humour
    Autorzy:
    Grabowski, Antoni
    Powiązania:
    https://bibliotekanauki.pl/articles/601359.pdf
    Data publikacji:
    2015
    Wydawca:
    Polska Akademia Nauk. Instytut Historii im. Tadeusza Manteuffla PAN w Warszawie
    Tematy:
    gender
    sex
    violence
    nudity
    castration
    humour
    Opis:
    Liudprand of Cremona is one of the most interesting authors of the tenth century. He is well known for his description of the Byzantine court and also for his jokes in Antapodosis – a first chronicle of Europe. Based on these tales, he is treated by scholars as a prime example of medieval misogyny. Lately the more political view of these narrations emerged, but still women in Liudprand’s works are seen mainly as victims. This essay shows that this view is wrong and that there is much more to be found in the text. Through Liudprand’s jokes emerges a much more complicated view of the position and role of woman in the society. To see this, the stories have to be put in the context of the tenth-century society.
    Źródło:
    Acta Poloniae Historica; 2015, 112
    0001-6829
    Pojawia się w:
    Acta Poloniae Historica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Apalutamide as a new option for postponing metastatic disease in hormone -resistant patients with biochemical recurrence in prostate cancer
    Autorzy:
    Dąbek, Bartosz
    Powiązania:
    https://bibliotekanauki.pl/articles/22676825.pdf
    Data publikacji:
    2023-04-04
    Wydawca:
    Medical Education
    Tematy:
    non-metastatic castration-resistant prostate cancer
    apalutamide
    Opis:
    Treatment of non-metastatic castration-resistant prostate cancer is a radically new option for cancer patients. Novel anti-hormonal therapy not only improves metastasis free survival but overall survival times and positively impacts quality of life. This case shows how apalutamide lowered tPSA level and postponed metastatic disease.
    Źródło:
    OncoReview; 2023, 13, 1; 24-26
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A novel orchiectomy surgical procedure in donkeys (Equus asinus africanus) with parascrotal access
    Autorzy:
    Barrêto JR, R.A.
    Rodrigues, L.A.
    Albuquerque, J.P.
    de Sousa, F.J.A.
    Firmino, P.R.
    Sousa, R.S.
    Pedrosa, V.J.
    do Amaral, T.R.
    Minervino, A.H.H.
    Powiązania:
    https://bibliotekanauki.pl/articles/16539181.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    inflammation
    donkeys
    peritoneal fluid
    surgical approach
    castration
    Opis:
    Donkeys are a public health concern in the Northeast region of Brazil, with thousands of stray animals. Orchiectomy is an important population control measure; however, the long postoperative period with daily treatment of open wounds in the scrotum makes it difficult to perform a large number of castrations in sheltering centers. We evaluate a novel surgical procedure for orchiectomy in donkeys using parascrotal access. Twelve donkeys were used, divided into two groups: I - submitted to orchiectomy through parascrotal surgical access (novel procedure), and II - submitted to orchiectomy through scrotal access (conventional). Postoperative evaluations consisted of a macroscopic evaluation of the surgical wound (bleeding and intensity of edema), hematological parameters, and peritoneal fluid, which occurred in both groups at the moments (M): M0 - before the surgical procedure. The others moments occurred after surgery: M12 (twelve hours); M24 (twenty-four hours); M48 (forty-eight hours); M72 (seventy-two hours); M8D (eight days); and M16D (sixteen days). The surgical techniques did not generate an important systemic inflammatory response to the point detected by the leukogram, fibrinogen dosage, and peritoneal fluid. The parascrotal technique required long surgery but promoted less bleeding, less edema, and faster healing. The techniques used did not promote sufficient systemic inflammation to alter the number of leukocytes and the fibrinogen concentration; however, evaluation of the peritoneal fluid proved to be important for evaluating inflammatory processes involving the scrotum and inguinal canal. We describe a novel surgical procedure for orchiectomy in Donkeys using a parascrotal access that promoted less risk of bleeding, shorter period of edema, and healing time, but required longer surgery time.
    Źródło:
    Polish Journal of Veterinary Sciences; 2022, 25, 2; 295-302
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Apalutamide in the treatment of a patient with non-metastatic castration-resistant prostate cancer
    Autorzy:
    Dziura, Robert
    Powiązania:
    https://bibliotekanauki.pl/articles/22676763.pdf
    Data publikacji:
    2023-03-31
    Wydawca:
    Medical Education
    Tematy:
    prostate cancer
    castration-resistant
    androgen receptor inhibitor
    Opis:
    The treatment of patients with prostate cancer, who do not qualify for the radical therapy is based on the use of surgical or pharmacological castration methods. The effectiveness of the so-called androgen deprivation tends to decrease over time. Even in the absence of distant metastases on imaging studies, the resistance for the hormonal castration may be developed. At this moment, the use of new generation androgen receptor inhibitors may reduce the risk of metastases or death. The paper presents a case report of a patient with prostate cancer without distant metastases who started therapy with apalutamide at the moment of developing re-sistance to the pharmacological castration.
    Źródło:
    OncoReview; 2023, 13, 1; 20-23
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cardiovascular complications during the treatment of castration-resistant prostate cancer with the use of modern antiandrogens: abiraterone acetate and enzalutamide
    Autorzy:
    Grabysa, Radosław
    Chmielewska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/2047222.pdf
    Data publikacji:
    2021-09-13
    Wydawca:
    Medical Education
    Tematy:
    abiraterone acetate
    enzalutamide
    castration resistant prostate cancer
    cardiovascular
    Opis:
    Modern antiandrogens: abiraterone acetate (inhibitor of CYP17 cytochrome) and enzalutamide (irreversible inhibitor of androgen receptor) are the drugs that are increasingly often administered in treatment of castration-resistant prostate cancer. Despite their clinical efficacy, especially in terms of prolonged survival and improved quality of life of patients, they pose of problem for a practicing oncologist such as possible cardiovascular complications (particularly arterial hypertension), which may lead to the cessation of this form of therapy. This article provides a brief overview of the mechanisms responsible for the above complications, including practical recommendations in the event such complications arise. A simple scheme of action for control of cardiovascular risk factors has been presented, which can improve the prognosis in this population of patients.
    Źródło:
    OncoReview; 2021, 11, 3; 61-67
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Apalutamide in the treatment of non-metastatic castration-resistant prostate cancer in an elderly patient with multiple comorbidities
    Autorzy:
    Liśkiewicz, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/22676727.pdf
    Data publikacji:
    2023-03-30
    Wydawca:
    Medical Education
    Tematy:
    non-metastatic castration-resistant prostatic cancer
    androgen receptor
    apalutamide
    Opis:
    Prostate cancer has been the most common malignant tumor in men in Poland since 2016 and is the second cause of death in this group of patients. The basic method of treatment in patients with advanced prostate cancer is androgen deprivation therapy, however, over time, the tumor evolves into a castration-resistant form, which poses a significant threat to the patient's life. This article presents a case of an elderly patient with internal diseases, who in the castration-resistant stage, was treated with a new generation androgen receptor blocker – apalutamide – in the first line of systemic treatment.
    Źródło:
    OncoReview; 2023, 13, 1; 9-12
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ masowej kastomizacji na rachunek kosztów produkcji – studium przypadku
    The influence of mass customization on the production cost – case study
    Autorzy:
    Burkat, Halina
    Powiązania:
    https://bibliotekanauki.pl/articles/586133.pdf
    Data publikacji:
    2018
    Wydawca:
    Uniwersytet Ekonomiczny w Katowicach
    Tematy:
    Koszty
    Masowa kastomizacja
    Studium przypadku
    Case study
    Costs
    Mass castration
    Opis:
    Masowa kastomizacja jako pojęcie uwzględniające wpływ klienta na produkt stała się przedmiotem zainteresowania badaczy naukowych. Celem poniższego artykułu jest próba wskazania jej wpływu na rozliczenie kosztów produkcji. Przedstawiono pojęcie masowej kastomizacji, zaprezentowano i opisano schemat rozliczeń produkcji na przykładzie przedsiębiorstwa produkującego stolarkę okienną. Wyjaśniono podstawowe grupy kosztów oraz kluczy rozliczeniowych. Omówiono działania, jakie zostały podjęte w firmie w obszarze operacyjnym oraz rachunkowości zarządczej w celu urealnienia informacji dotyczących przepływu danych w procesie.
    Mass customization as a concept takes into account the impact of the customer on the product has become a source of interest for researchers. The purpose of the article below is an attempt to indicate impact mass customization on production costs. The concept of mass customization has been presented, the production costs have been presented and described on the example of a window manufacturing company. Basic cost groups and billing keys have been explained. The activities that were taken in the company in the operational area and management accounting have been discussed.
    Źródło:
    Studia Ekonomiczne; 2018, 369; 19-28
    2083-8611
    Pojawia się w:
    Studia Ekonomiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Benedict Hesse’s Teaching on Conjugal Abstinence
    Autorzy:
    Ozorowski, Mieczysław
    Powiązania:
    https://bibliotekanauki.pl/articles/2149958.pdf
    Data publikacji:
    2021
    Wydawca:
    Uniwersytet w Białymstoku. Wydawnictwo Uniwersytetu w Białymstoku
    Tematy:
    Benedict Hesse
    conjugal chastity
    conjugal abstinence
    virginity
    castration
    spousal dress
    Opis:
    This article focuses on conjugal abstinence in the teaching of the great Polish theologian, Benedict Hesse, who lived and worked in Cracow during the fifteenth century. In his work Commentary on the Gospel of St. Matthew, Hesse focuses his discussion on chastity and conjugal abstinence in the context of several other subjects, including: the superiority of virginity over marriage; the superiority of virginal chastity over conjugal abstinence; the issue of assessing the pleasure of conjugal sexual intercourse; matters pertaining to modesty of the spouses and their exterior appearance; as well as castration for the Kingdom of Heaven. The issues that Hesse raises in relation to chastity and conjugal abstinence might bring a smile to a contemporary reader’s face, since they seem mostly anecdotal and basic. This article is not a complete and systematic lecture on conjugal abstinence.
    Źródło:
    Rocznik Teologii Katolickiej; 2021, 20; 49-71
    1644-8855
    Pojawia się w:
    Rocznik Teologii Katolickiej
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prostate cancer in clinical practice. First experiences with apalutamide within the context of therapeutic program B.56
    Autorzy:
    Trzebiński, Krzysztof
    Powiązania:
    https://bibliotekanauki.pl/articles/22676841.pdf
    Data publikacji:
    2023-04-01
    Wydawca:
    Medical Education
    Tematy:
    non-metastatic castration-resistant prostate cancer
    apalutamide
    androgen receptor inhibitor
    Opis:
    The article contains a case report of patient diagnosed with castration-resistant non-metastatic prostate cancer, treated with a novel androgen receptor inhibitor – apalutamide.
    Źródło:
    OncoReview; 2023, 13, 1; 27-30
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Les diaboliques du Perlesvaus ou les fantasmes de castration
    Autorzy:
    Gorecka-Kalita, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/638356.pdf
    Data publikacji:
    2015
    Wydawca:
    Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
    Tematy:
    Grail romance, Middle Ages, woman, phantasm, fantasy, violence, sexual desire, castration, devilry
    Opis:
    The article investigates two mysterious feminine figures appearing in the 13th century Old French prose romance Le Haut Livre du Graal (Perlesvaus). Their ontological status, which remains uncertain until the end, gives them, along with the sexual violence and castration phantasms they incarnate, a highly troubling and uncanny aspect. The analysis highlights also the textual strategies used by the author in order to create such an effect
    Źródło:
    Romanica Cracoviensia; 2015, 15, 4
    2084-3917
    Pojawia się w:
    Romanica Cracoviensia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Survival outcome and prognostic factors in patients with chemotherapy-naive metastatic castration-resistant prostate cancer treated with abiraterone acetate – real-world experience in Vietnam
    Autorzy:
    Do, Tu Anh
    Nguyen, Thai Hoa Thi
    Nguyen, Hau Xuan
    Nguyen, Loi Dinh
    Nguyen, Chu Van
    Powiązania:
    https://bibliotekanauki.pl/articles/40555372.pdf
    Data publikacji:
    2024-06-30
    Wydawca:
    Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
    Tematy:
    abiraterone acetate
    metastatic castration-resistant prostate cancer
    overall survival
    real-world evidence
    Opis:
    Introduction and aim. In real life, metastatic castration-resistant prostate cancer patients (mCRPC) had more complex clinical presentation than patients in the COU-AA-302 trial. This study primarily aimed to describe the overall survival of chemotherapy-naive mCRPC treated with abiraterone acetate plus prednisone (AAP). Other relevant outcomes and baseline characteristics of these patients were also evaluated. Material and methods. This retrospective, observational study collected data from chemotherapy-naive mCRPC patients treated with AAP in Vietnam. Kaplan-Meier curves were used to estimate time to treatment failure (TTF), and overall survival (OS). The impact of baseline characteristics on OS was explored using univariate and multivariate Cox proportional hazard models. Results. Data from 65 eligible patients were analyzed. The rate of PSA response was 73.8%, median PSA PFS was 10.5 months (95% CI: 7.4–13.6), median TTF was 15 months (95% CI: 11.1–18.9), and median OS was 24.9 months (95% CI: 18.9–30.9). Shorter OS was significantly associated with a higher Gleason score (≥8), shorter time from ADT start to mCRPC (<12 months), visceral metastases, and <50% PSA decline (p<0.05). Conclusion. Abiraterone acetate plus prednisone is well tolerated and effective for chemotherapy-naive mCRPC patients in clinical practice. Moreover, Gleason score, visceral metastasis, time from ADT start to mCRPC, and PSA response are the independent indicators for predicting the OS of mCRPC patients in both univariate and multivariate analyses.
    Źródło:
    European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 262-269
    2544-2406
    2544-1361
    Pojawia się w:
    European Journal of Clinical and Experimental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Płeć jako arche, czyli czy według Arystotelesa możliwa jest zmiana płci?
    Sex as arche, or is sex change possible according to Aristotle?
    Autorzy:
    Sowa, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/18678688.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    Arystoteles
    De generatione animalium
    płeć
    zmiana płci
    kastracja
    Aristotle
    sex
    sex change
    castration
    Opis:
    According to Aristotle’s views presented in his logical works and Metaphysics, sex appears to be an essential attribute of the genus animal, and maleness and femaleness are a pair of contrary qualities, although it is not quite clear what sort of contrariety Aristotle understands the contrariety of sex to be. As qualities admit of variation of degree, and in the case of contraries there are possible changes from one into the other, in this article I address the question if the sex of an individual animal can also be changed into the opposite one. In De generatione animalium Aristotle describes sex as arche — arche of generation, but also arche of every animal’s external appearance and generative ability. Aristotle applies this term to two body parts, which he presents as factors determining sex: the heart as an origin of natural heat, and, above all, the genitals. In the case of males, destruction of the latter, i.e. castration, is depicted as a sex change, because the male becomes like the female in respect of external form and lack of generative power. As change in the other direction is impossible, we can conclude that the contrariety of sex seems to be, according to Aristotle, an opposition of possession and privation.
    Źródło:
    Internetowy Magazyn Filozoficzny Hybris; 2016, 32, 1; 73-95
    1689-4286
    Pojawia się w:
    Internetowy Magazyn Filozoficzny Hybris
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Apalutamid for treatment of nonmetastatic castration-resistant prostate cancer - case study
    Autorzy:
    Sikora-Kupis, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/22676707.pdf
    Data publikacji:
    2023-03-31
    Wydawca:
    Medical Education
    Tematy:
    non-metastatic castration-resistant prostate cancer
    nmCRPC
    androgen receptor targeted agents
    ARTA
    apalutamide
    darolutamide
    enzalutamide
    Opis:
    A special form of prostate cancer is non-metastatic castration-resistant prostate cancer. Patients with this form have rising prostate-specific antigen and castrate testosterone levels, with no radiological findings of metastatic disease on computed tomography and bone scan. The phase III trials demonstrated apalutamide, darolutamide or enzalutamide to be associated with a significantly longer median metastasis-free survival. The featured description presents one case of man with non-metastatic castration-resistant prostate cancer who was treated with apalutamide.
    Źródło:
    OncoReview; 2023, 13, 1; 6-8
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
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