Skocz do pozycji: 1.

Tytuł:

Higher Apoptosis Index and Proliferation Index in Colonocytes of Patients with Ulcerative Colitis in Remission

Autorzy:

Buczyński, Jarosław
Spychalski, Michał
Ławska-Wierzchniewska, Agnieszka
Dziki, Adam

Powiązania:

https://bibliotekanauki.pl/articles/1396694.pdf

Data publikacji:

2012-06-01

Wydawca:

Index Copernicus International

Tematy:

apoptosis
proliferation
ulcerative colitis

Opis:

Ulcerative colitis (UC) is a inflammatory disease of large bowel. The amount of people suffering from UC increases from year to year. Pathogenesis of this affection is still not entirely clear. Mechanisms of proliferation and apoptosis in colonocytes in the course of the disease are defectedThe aim of the study was to assess the rate of proliferation and intensity of apoptosis in colonocytes in patients with diagnose UC.Material and methods. Colon pathological samples taken from patients with diagnosed ulceraive colitis were examined. Patients were in both clinical and endoscopic remission and were treated with mesalazin. They were patient of Department of General and Colorectal Surgery. To estimate proliferation index dye with monoclonal antibody against Ki67. To determine apoptosis level immunohistochemistry with antybody against Bax was used.Results. Average Ki-67 in the test group was 42,13%, the largest value amounted to 57% and the lowest of 33%. Average value of Bax was 1.47 and ranged between 0-3. High index of bax appear not only in the bottom of the crypt, but also at their outlet.Conclusions. In ulecerative colitis genetic and immunological disturbances occur despite treatment. Mesalazine acting only on certain routes associated with the UC holds the remission, without, however "the molecular remission". Thus, it appears that the results of our research are another proof of the necessary caution in weaning support treatment.

Źródło:

Polish Journal of Surgery; 2012, 84, 6; 271-275
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 2.

Tytuł:

The influence of fractionated radiation on proliferation, cell cycle and apoptosis of normal human dermal fibroblasts

Autorzy:

Adamczyk, A.
Gasińska, A.

Powiązania:

https://bibliotekanauki.pl/articles/147800.pdf

Data publikacji:

2005

Wydawca:

Instytut Chemii i Techniki Jądrowej

Tematy:

fibroblasts
fractionated irradiation
proliferation
radiosensitivity

Opis:

The aim of the study was to investigate the changes in proliferation rate, cell cycle and apoptosis of normal skin fibroblasts during fractionated irradiation with a fraction dose of 2 Gy. Fibroblasts were irradiated 5 days per week for 12 days using gamma irradiation. Twenty four hours after each fraction, and for three days after finishing experiment the cells were harvested, fixed, and BrdUrd labelling index (BrdUrdLI), cell cycle and level of apoptosis and debris were assessed. It was found that fractionated irradiation caused disturbances in the proliferation rate and the cell cycle. Irradiation caused also constant, statistically significant increase in the number of G2M cells and level of apoptosis and debris, which was observed even during 3 days after irradiation. Data indicate non equal biological effect of each fraction dose. Block at G2/M phase suggests accumulation of sublethal damage and increased radiosensitivity, which was manifested by elevated level of cell death (apoptosis and debris).

Źródło:

Nukleonika; 2005, 50,suppl.2; 9-12
0029-5922
1508-5791

Pojawia się w:

Nukleonika

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 3.

Tytuł:

Proliferation of Democratic Education in Indonesia: The Influence Measurement of Tolerance, Multiculturalism, and Historical Awareness on the Democratic Attitude

Autorzy:

Sumardjoko, Bambang
Joebagio, Hermanu
Sariyatun, -

Powiązania:

https://bibliotekanauki.pl/articles/1969412.pdf

Data publikacji:

2018-06-30

Wydawca:

Wydawnictwo Adam Marszałek

Tematy:

democratic education
proliferation
democratic attitude

Opis:

This research aims to predict the direction of democratic education in Indonesia through the influence measurement of tolerance, multicultural sensitivity, and historical awareness of the democratic attitude. The multiple linear regression test, coefficient determination test, and model accuracy test were used to measure the influence of the predictors and the dependent variable. The research participants were 300 students, aged between 17 and 18 years, who were taken proportionally in Senior High School (SHS) 1 Surakarta, SHS 5 Surakarta, and SHS 6 Surakarta. Results showed a simultaneous and partial influence of tolerance, multicultural sensitivity, and historical awareness on the democratic attitude. The authors found that there is no diversion in the proliferation of democratic education in Indonesia, in which tolerance, multicultural sensitivity, and historical awareness have a positive influence on the democratic attitude. However, the authors stated that the association between tolerance and democratic education in Indonesia remains problematic, thus, it should be noticed in future research.

Źródło:

The New Educational Review; 2018, 52; 112-123
1732-6729

Pojawia się w:

The New Educational Review

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 4.

Tytuł:

Pakistański program nuklearny w kontekście typologii modeli proliferacji Scotta D. Sagana
Pakistani Nuclear Program in the context of Scott D. Sagan’s Models of Nuclear Proliferation

Autorzy:

Kopeć, Rafał

Powiązania:

https://bibliotekanauki.pl/articles/1953231.pdf

Data publikacji:

2015-06-30

Wydawca:

Wydawnictwo Adam Marszałek

Tematy:

proliferation
security model
nuclear program

Opis:

The aim of the paper is to present the Pakistani nuclear program in the context of Scott D. Sagan’s models describing the causes of nuclear weapons proliferation. The typology consists of three models: the security, the domestic policy, and the norms. The author claims that the Pakistani program would be the most adequately present using the security model. The program was a response to both conventional and nuclear threat from India, which has been in permanent conflict with Pakistan.

Źródło:

Athenaeum. Polskie Studia Politologiczne; 2015, 46; 147-160
1505-2192

Pojawia się w:

Athenaeum. Polskie Studia Politologiczne

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 5.

Tytuł:

PEGYLATED GEMCITABINE AND METHOTREXATE: IN VITRO CYTOTOXICITY ANALYSIS AND IN VIVO DRUG RELEASE PROFILING TO ASSESS THEIR ENHANCED BLOOD CIRCULATION

Autorzy:

Ahmed, Mahmood

Powiązania:

https://bibliotekanauki.pl/articles/895274.pdf

Data publikacji:

2019-08-30

Wydawca:

Polskie Towarzystwo Farmaceutyczne

Tematy:

drug delivery
anti-proliferation
Pegylation
spheroids

Opis:

In the present study, four new pegylated drugs were synthesized to investigate the anticancer activity. All the compounds were characterized on the basis of FTIR and 1HNMR. The new compounds were evaluated against HCT116 cell line by CellTiter-Glo® 3D cell viability assay. The sustained release pattern of newly synthesized compounds were also evaluated, slow released lasts for 240 h which was confirmed by in vivo and in vitro drug release profile. The sustained and controlled release behavior of pegylated drugs over the extended period of time showed a linear profile and this release pattern was not limited to diffusion process instead supporting chemically controlled release pattern which was dependent only on how fast the compound hydrolyzed. The newly designed pegylated drugs showed almost same killing effect against the cancer cells as the free drugs. The compounds with lower cLogP value showed more antiproliferative (lower IC50) effect due their higher cell permeability.

Źródło:

Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 653-659
0001-6837
2353-5288

Pojawia się w:

Acta Poloniae Pharmaceutica - Drug Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 6.

Tytuł:

A novel polypeptide from Cervus nippon Temminck proliferation of epidermal cells and NIH3T3 cell line

Autorzy:

Guan, Shu-Wen
Duan, Leng-Xin
Li, Yuan-Yuan
Wang, Ben-Xiang
Zhou, Qiu-Li

Powiązania:

https://bibliotekanauki.pl/articles/1041255.pdf

Data publikacji:

2006

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

polypeptide
velvet antler
promoting cell proliferation

Opis:

A novel polypeptide, velvet antler polypeptide (VAPPs), having a stimulary effect on proliferation of some cell was isolated from the velvet antler of sika deer (Cervus nippon Temminck). This polypeptide consists of a single chain of 32 amino-acid residues VLSAT DKTNV LAAWG KVGGN APAFG AEALE RM. VAPPs showed marked stimulary effect on rat epidermal cells and NIH3T3 cell line (dose range from 10-40 mg·L-1 and 5-80 mg·L-1, respectively).

Źródło:

Acta Biochimica Polonica; 2006, 53, 2; 395-397
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 7.

Tytuł:

Socialisation of International Rules. Exploring Alternative Mechanisms for Securing Compliance with International Humanitarian Law by Armed Groups
Uspołecznianie międzynarodowych zasad. Badanie alternatywnych mechanizmów dla gwarantowania zgodności z międzynarodowym prawem humanitarnym (IHL) w działaniu ugrupowań zbrojnych

Autorzy:

cholewinska, agnieszka j.

Powiązania:

https://bibliotekanauki.pl/articles/2141079.pdf

Data publikacji:

2019-12-26

Wydawca:

Wydawnictwo Naukowe Dolnośląskiej Szkoły Wyższej

Tematy:

proliferation
socialization
international humanitarian law (IHL)

Opis:

Proliferation of internal armed conflicts poses a challenge to the framework of international humanitarian law (IHL) as it was primarily designed to guide states’ behaviour while at war. Are the existing mechanisms available under IHL sufficient to ensure compliance with the law by armed groups? The purpose of this article is to examine how socialisation, by which I mean a process of internalising a norm or a rule so that external pressure is no longer necessary to ensure compliance, might contribute to producing long-term rule-consistent behaviour. I begin with the identification of the legal framework applicable to internal conflicts and challenges associated with its implementation. Following is the discussion of the ideas on socialisation and their utility in the context of IHL and armed groups. I then proceed to present a particular example of positive engagement with such groups under the so-called Deed of Commitment, launched by a Swiss NGO, Geneva Call. Finally, I return to my analytical framework, apply it to the system established under the Deed of Commitment, and assess to what extent socialisation and positive engagement may ensure greater respect for humanitarian rules. I conclude that socialisation is a valuable tool that may complement the existing mechanisms under IHL and, under certain conditions, contribute to long-term rule-consistent behaviour.
Rozprzestrzenianie się międzynarodowych konfliktów zbrojnych gromadzi wyzwania dla zakresu oddziaływania międzynarodowego prawa humanitarnego (IHL), którego założycielską ideą było kształtowanie zasad zachowania państw w czasie wojen. Dlatego należy zadać pytanie, czy istniejące mechanizmy w zakresie międzynarodowego prawa humanitarnego (IHL) są wystarczające, aby zapewnić zgodność w zakresie prawnym w odniesieniu do funkcjonowania ugrupowań zbrojnych? Ideą tego artykułu jest zbadanie, jak uspołecznienie, prze która autorka postrzega proces umiędzynarodowienia zasad lub reguł, tak aby zewnętrzny wpływ nie był dalej konieczny, w zapewnieniu zgodności, co w perspektywie może być źródłem do tworzenia długoterminowych spójnych zasad zachowań. We wstępie artykułu wyszczególniono ramy prawne mające zastosowanie w konfliktach zbrojnych oraz wyzwań towarzyszących ich wdrażaniu. W dalszych rozważania jest prezentowana dyskusja koncepcji uspołeczniania oraz jej przydatność w kontekście międzynarodowego prawa humanitarnego (IHL) oraz działania ugrupowań zbrojnych. W dalszej części autorka przechodzi do prezentowania wybranych przykładów pozytywnej współdziałania z takimi ugrupowaniami w ramach tzw.„Deed of Commitment”, czyli inicjatywa aktów dobrej woli zorganizowana przez Szwajcarskie Organizacje Pozarządowe (NGOs), Geneva Calls. Ostatecznie autorka powraca do analitycznego obszaru badawczego i odnosi wyniki badan do ram działań w systemie ustanowionym przez „Deed of Commitment”, aby ostatecznie ocenić w jakim zakresie uspołecznienie oraz pozytywne zaangażowanie mogą zapewnić większe zrozumienie dla stosowania humanitarnych zasad. W podsumowaniu, stwierdza się, że uspołecznienie jest znakomitym narzędziem, który może uzupełniać mechanizmy funkcjonowania międzynarodowego prawa humanitarnego (IHL) oraz w szczególnych warunkach wnosić wartość dodaną do długoterminowych spójnych zasad zachowań.

Źródło:

Rocznik Bezpieczeństwa Międzynarodowego; 2013, 7; 317-336
1896-8848
2450-3436

Pojawia się w:

Rocznik Bezpieczeństwa Międzynarodowego

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 8.

Tytuł:

Antigen-specific lymphocyte proliferation as a marker of immune response in guinea pigs with sustained Helicobacter pylori infection

Autorzy:

Miszczyk, Eliza
Walencka, Maria
Rudnicka, Karolina
Matusiak, Agnieszka
Rudnicka, Wiesława
Chmiela, Magdalena

Powiązania:

https://bibliotekanauki.pl/articles/1039292.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Helicobacter pylori
T cells
proliferation
guinea pigs

Opis:

Helicobacter pylori (H. pylori) bacteria are human pathogens causing symptomatic gastritis, peptic ulcer or gastric cancer. Little is known about the kinetics of immune responses in H. pylori infected patients because the initial moment of infection has not been identified. Various animal models are used to investigate the immune processes related to H. pylori infection. In this study we checked whether H. pylori infection in guinea pigs, mimicking natural H. pylori infection in humans, resulted in the development of specific immune responses to H. pylori antigens by measuring the proliferation of lymphocytes localized in mesenteric lymph nodes, spleen and peripheral blood. The maturity of macrophages and cytokines, delivered by monocyte-macrophage lineage or lymphocytes, were considered as mediators, which might influence the lymphocyte blastogenic response. The obtained results showed the activation of T cells localized in mesenteric lymph nodes by H. pylori antigens in H. pylori infected guinea pigs four weeks postinfection. The blastogenic activity of lymphocytes was shaped by their interaction with antigen presenting cells, which were present in the cell cultures during the whole culture period. Moreover, the balance between cytokines derived from adherent leukocytes including interleukin 8 - IL-8 as well as interferon gamma - IFN-γ, and transforming growth factor beta - TGF-β delivered by lymphocytes, was probably important for the successful proliferation of lymphocytes. The H. pylori specific lymphocytes were not propagated in peripheral blood and spleen of H. pylori infected animals. The modulation of immunocompetent cells by H. pylori antigens or their different distribution cannot be excluded.

Źródło:

Acta Biochimica Polonica; 2014, 61, 2; 295-303
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 9.

Tytuł:

Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies

Autorzy:

Koczurkiewicz, Paulina
Czyż, Jarosław
Podolak, Irma
Wójcik, Katarzyna
Galanty, Agnieszka
Janeczko, Zbigniew
Michalik, Marta

Powiązania:

https://bibliotekanauki.pl/articles/1038965.pdf

Data publikacji:

2015

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

triterpene saponins
cancer cells
invasiveness
apoptosis
proliferation

Opis:

Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cytotoxic, cytostatic, pro-apoptotic and anti-invasive effects. At high concentrations (more than 100 µM) saponins exert cytotoxic and haemolytic effects via permeabilization of the cell membranes. Noteworthy, the inhibition of cancer cell proliferation, the induction of apoptosis and attenuation of cell invasiveness is observed in the presence of low saponin concentrations. Saponins might affect the expression of genes associated with malignancy. These alterations are directly related to the invasive phenotype of cancer cells and depend on "cellular context". It illustrates the relationships between the action of saponins, and the momentary genomic/proteomic status of cancer cells. Here, we discuss the hallmarks of anti-cancer activity of saponins with the particular emphasis on anti-invasive effect of diverse groups of saponins that have been investigated in relation to tumor therapy.

Źródło:

Acta Biochimica Polonica; 2015, 62, 3; 383-393
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 10.

Tytuł:

Artificial extracellular matrices of collagen fibrils and lactoferrin as coatings to enhance osteoblast behavior

Autorzy:

Vandorovcova, M.
Bacakova, L.
Dubruel, P.
Douglas, T. E. L.

Powiązania:

https://bibliotekanauki.pl/articles/284321.pdf

Data publikacji:

2012

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

coating
collagen
osteoblasts
proliferation
extracellular matrix
lactoferrin

Opis:

Lactoferrin, a glycoprotein found in milk, has stimulated osteoblast proliferation and differentiation, but has remained relatively unexplored as a biomaterial component. In this study, artificial extracellular matrices consisting of fibrils of collagen type I containing lactoferrin were used as coatings for the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA). The numbers of cells, their viability and proliferation rate were evaluated in various time intervals. Additionally, cell initial spreading area on day 1 was measured. The results show that lactoferrin accelerates fibril-logenesis, leads to increased osteoblast cell numbers 1 and 3 days post-seeding, and encourages their proliferation in each of the tested time intervals.

Źródło:

Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 132-134
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 11.

Tytuł:

The impact of the proliferation of ballistic missiles technology on international security

Autorzy:

Indyk, Jarosław

Powiązania:

https://bibliotekanauki.pl/articles/22180775.pdf

Data publikacji:

2023-09-30

Wydawca:

Wydawnictwo Adam Marszałek

Tematy:

Ballistic missile
proliferation
international security
technology
globalization

Opis:

Due to the rapid development of technology after the Second World War, the way of conducting conflict has changed significantly. One of the branches of the armaments industry that has developed the most is space technology and related to it ballistic missiles. Undoubtedly, possession by international entity ballistic missile technology, especially in connection with weapons of mass destruction, increases the importance and role of this entity on the international arena. Therefore, the proliferation of this technology or ready-made missile systems has a significant impact on regional and international security. Therefore, in order to explain this phenomenon, the first part of the article describes the role of ballistic missiles for international security. In the second part, author describes varied ways how international actor, such a state or organization may come into possession of ballistic missiles and also the methods used to stop or limit proliferation i.e. counter-proliferation methods. The last part of this article describes the ways how selected examples states such us Egypt, People’s Republic of China, Israel, India, North Korea, Iraq and South Africa have come into possession of ballistic missile technology. In connection with the above, it will be possible to show what proliferation of this kind of technology looked like and may look like in practice.

Źródło:

Polish Political Science Yearbook; 2023, 3(53); 165-179
0208-7375

Pojawia się w:

Polish Political Science Yearbook

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 12.

Tytuł:

Atom od Bosforu po Zatokę Perską – perspektywy energetyki jądrowej na Bliskim Wschodzie
The atom from the Bosphorus to the Persian Gulf – the perspective of nuclear power in the Middle East

Autorzy:

Tolak, Łukasz

Powiązania:

https://bibliotekanauki.pl/articles/527007.pdf

Data publikacji:

2014

Wydawca:

Collegium Civitas

Tematy:

Nuclear Energy
Industry
Proliferation
Nuclear Power Plant

Opis:

The article is an attempt to analyze the current situation and plans for the development of the nuclear industry in the Middle East after the failure in Fukushima. Next to the southern and eastern Asian countries nuclear power becomes a choice of countries of the Middle East region. Taking into account the significant gaps in economic and scientific potential, and the unstable political situation in the countries of the region – projects to build nuclear power stations seem to be a particularly complex challenge. The article analyzes the entered and planned investments and risks, which may arise in connection with the implementation of adopted plans.

Źródło:

Securitologia; 2014, 2(20); 101-114
1898-4509

Pojawia się w:

Securitologia

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 13.

Tytuł:

CAMPTOTHECIN INHIBITS MIGRATION, INVASION AND CLONOGENIC PROPERTY OF LIVER CANCER CELLS BY MODULATING MICRORNA EXPRESSION

Autorzy:

Liu, Zhenzhong
Wu, Song
Li, Xiaoqian

Powiązania:

https://bibliotekanauki.pl/articles/895460.pdf

Data publikacji:

2020-04-29

Wydawca:

Polskie Towarzystwo Farmaceutyczne

Tematy:

Hepatocellular Carcinoma
cell proliferation
cell cycle
Camptothecin
miRNA

Opis:

Camptothecin (CPT), an alkaloid natural product, extracted from Camptotheca acuminata bark, has been reported to have potential antitumor activity in diverse cancers. MicroRNAs (MiRNAs) are a class of short, non-coding RNAs that plays a crucial role in the normal physiology by attenuating translation. Here, we showed that the CPT modulates the expression of miRNAs in hepatocellular carcinoma cells (HCC). Microarray analysis reveals that CPT modulates the expression of as many as 39 miRNAs in HCC cells (Huh7), 27 miRNAs were downregulated whereas 12 miRNAs were upregulated. miR-16 is the key miRNA upregulated by CPT and targets key prosurvival proteins (MMP-2, MMP-9 and cyclin D1). Our results demonstrate that CPT is inhibiting cell viability of HCC cells significantly when compared with the untreated cells. Wound healing and colony formation assay confirm inhibition of cell migration and clonogenic property of Huh7 cells respectively, upon the dose-dependent treatment of CPT. Furthermore, the Boyden chamber assay analysis revealed a significant inhibition of number of invasive cells in CPT treated cells with comparison to untreated Huh7 cells. Mechanistically, CPT upregulates miR-16 expression which targets MMP-2, MMP-9, cyclin D1 downregulation and subsequently upregulates the expression of E-cadherin, TIMP1, p21, and p27, thereby inhibits cell migration, invasion and clonogenic property of HCC cells. In summary, CPT treatment in Huh7 cells decreases cell viability and upregulates miR-16 expression, which results in inhibition of cell migration, invasion and clonogenic property of cells, by decreasing MMP-2, MMP-9, cyclin D1 and increasing the expression of cell cycle-regulated proteins p21 and p27.

Źródło:

Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 295-304
0001-6837
2353-5288

Pojawia się w:

Acta Poloniae Pharmaceutica - Drug Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 14.

Tytuł:

Proliferacja osteoblastów Saos-2 oraz komórek endotelialnych EA.hy 926 na polerowanych i piaskowanych powierzchniach stopów tytanu Ti6Al4V i Ti6Al7Nb
Proliferation of human osteoblast-like cells Saos-2 and human endothelial cells EA.hy 929 on polished and sandblasted surfaces of titanium alloys Ti6Al4V and Ti6Al7Nb

Autorzy:

Walkowiak-Przybyło, M.
Walczyńska, M.
Komorowski, P.
Klimek, L.
Walkowiak, B.

Powiązania:

https://bibliotekanauki.pl/articles/285427.pdf

Data publikacji:

2011

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

osteoblasty
stopy tytanu
proliferacja
osteoblasts
titanium alloys
proliferation

Źródło:

Engineering of Biomaterials; 2011, 14, no. 109-111 spec. iss.; 39-41
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 15.

Tytuł:

Small arms and light weapons proliferation: implications for security and sustainable development in Nigeria

Autorzy:

Igbini, Mevayerore Daniel

Powiązania:

https://bibliotekanauki.pl/articles/1375725.pdf

Data publikacji:

2020

Wydawca:

Międzynarodowy Instytut Innowacji Nauka – Edukacja – Rozwój w Warszawie

Tematy:

Small arms
light weapons
proliferation
insecurity
sustainable development

Opis:

Throughout the world, violence, delinquency and fear undermine the basic right of individuals to live in peace and fully benefit from the healthy and sustainable commu-nity. More worrisome is the seemingly uncontrollable proliferations of small and light weapons which remained one of the major challenges for security and sustainable development in Nigeria. It is against this backdrop that this study examines the threats that small arms and light weapons proliferation portends on the Nigerian security and sustainable development. They study relied on secondary data and utilizes the content analysis for interpretation of data. This study is anchored on the state failure theory to underscore situations that warrant recourse to small arms and light weapons. The study concludes that the debilitating economy, failure of the state to provide the basic necessities of life, corruption, high rate of youth unemployment and sluggishness among the state’s instrument of force viz: the Army, police etc., are some of the major factors that serve as challenges to meaningful efforts and policies at combating the menace in the country. This study therefore recommends among others that the gov-ernment in all levels should embark on poverty alleviation programs and provide em-ployment opportunities to unemployed youths. This will discourage youths from join-ing ethnic militias and other militant groups that pose threats to peace and security in Nigeria.
Przemoc, przestępczość i strach na całym świecie podważają podstawowe prawo jednostek do życia w pokoju oraz w zdrowej i zrównoważonej społeczności. Bardziej niepokojące są pozornie niekontrolowana proliferacja broni ręcznej strzeleckiej i lekkiego uzbrojenia, która pozostała jednym z głównych wyzwań dla bezpieczeństwa i zrównoważonego rozwoju w Nigerii. Na tym tle niniejsze badanie analizuje zagrożenia, jakie proliferacja broni ręcznej strzeleckiej i lekkiego uzbrojenia stanowi dla bezpieczeństwa i zrównoważonego rozwoju Nigerii. Badacze oparli się na danych wtórnych i wykorzystują analizę treści do interpretacji danych. Badanie opiera się na teorii niepowodzenia państwa w celu podkreślenia sytuacji, które uzasadniają użycie broni ręcznej strzeleckiej i uzbrojenia lekkiego. W badaniu stwierdzono, że osłabiona gospodarka, niezdolność państwa do zapewnienia podstawowych potrzeb życiowych, korupcja, wysoki wskaźnik bezrobocia wśród młodzieży i opieszałość struktur siłowych, a mianowicie armii, policji itp., to tylko niektóre z głównych czynników, które stanowią wyzwanie dla znaczących wysiłków i polityk walki ze wspomnianym zagrożeniem w kraju. W niniejszym badaniu zaleca się zatem między innymi, aby rząd na wszystkich szczeblach rozpoczął programy zmniejszania ubóstwa i zapewnił możliwości zatrudnienia bezrobotnej młodzieży. To zniechęci młodzież do przyłączania się do bojówek etnicznych i innych grup bojowników, które stanowią za-grożenie dla pokoju i bezpieczeństwa w Nigerii.

Źródło:

International Journal of New Economics and Social Sciences; 2020, 11(1); 289-296
2450-2146
2451-1064

Pojawia się w:

International Journal of New Economics and Social Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 16.

Tytuł:

The effect of indole-3-carbinol on the expression of CYP1A1, CYP1B1 and AhR genes and proliferation of MCF-7 cells

Autorzy:

Ociepa-Zawal, Marta
Rubiś, Błażej
Łaciński, Mariusz
Trzeciak, Wiesław

Powiązania:

https://bibliotekanauki.pl/articles/1041121.pdf

Data publikacji:

2007

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

p21
AhR
CYP
cell proliferation
estrone hydroxylation
xenoestrogens

Opis:

The influence of an antiestrogen, indole-3-carbinol (I3C) on the expression of CYP1A1, CYP1B1 and AhR genes was investigated in an attempt to establish whether I3C could increase the expression of genes involved in estrone metabolism. Another purpose was to examine the proliferation of an estrogen-dependent breast cancer cell (MCF-7 line) under the influence of I3C and both I3C and DDT. In MCF-7 cells incubated with I3C or I3C and DDT combined, quantitative RT-PCR analysis revealed a significant increase in the level of CYP1A1, AhR, and CYP1B1 transcripts. The proliferation rate of MCF-7 cells was increased by treatment with DDT or estradiol (E2), whereas I3C did not affect the proliferation of MCF-7 cells but greatly reduced the stimulatory effect of DDT, and abolished the effect of E2. The level of p21 transcript, encoding p21 protein involved in the cell cycle, was increased several-fold by I3C comparing to its level in cells incubated with estradiol or DDT. The results suggest that the proliferation of MCF-7 cells is accompanied not only by expression of genes encoding cytochromes involved in estrogen metabolism, but also by changes in the expression of other genes including that encoding p21 protein involved in the cell cycle.

Źródło:

Acta Biochimica Polonica; 2007, 54, 1; 113-117
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 17.

Tytuł:

Association between clinical stage of oral cancer and expression of immunohistochemical markers

Autorzy:

Świątkowski, Wojciech
Rahnama, Mansur
Tomaszewski, Tomasz
Bigas, Mariola
Świątkowska, Agnieszka
Łobacz, Michał
Wallner, Jan

Powiązania:

https://bibliotekanauki.pl/articles/1393147.pdf

Data publikacji:

2017

Wydawca:

Index Copernicus International

Tematy:

oral cancer
neoplasm markers
squamous cell carcinoma
proliferation markers

Opis:

Aim: The aim of this study is to demonstrate the possible correlation between the expression of examined protein markers - p53, EGFR, PCNA, p44/42 in the mass of the tumor and the clinical stage of disease. Material: 48 patients of the Department and Clinic of Oral and Maxillofacial Surgery, Lublin diagnosed with oral cancer. The control group consisted of 10 patients diagnosed with leukoplakia lesions in the oral cavity. The methods: Immunohistochemical analysis using the detection system DAKO K5007 Cat - Dako REAL ™ Detection System, Peroxidase DAB +, Rabbit / Mouse. Results: Based upon the statistical results, significant correlation between p53 protein and tumor staging; however, a correlation between the level of expression of EGFR, p44/42, PCNA and staging was not likewise revealed. Conclusions: Looking for oral squamous cell carcinoma markers remains an actual issue. Identification of specific markers of oral cancer could be used in screening the population, determining prognosis and response to treatment.

Źródło:

Polish Journal of Surgery; 2017, 89, 6; 17-22
0032-373X
2299-2847

Pojawia się w:

Polish Journal of Surgery

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 18.

Tytuł:

Elevated expression of serine/threonine phosphatase type 5 correlates with malignant proliferation in human osteosarcoma

Autorzy:

Han, Kun
Gan, Zhihua
Lin, Shuchen
Hu, Haiyan
Shen, Zan
Min, Daliu

Powiązania:

https://bibliotekanauki.pl/articles/1038676.pdf

Data publikacji:

2017

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

cell proliferation
lentivirus
Osteosarcoma
PP5
siRNA
targeted therapy

Opis:

Osteosarcoma is the most common primary malignant bone tumor in adolescents and young adults. However, the involvement of serine/threonine phosphatase type 5 (PP5) in osteosarcoma remains unclear. The aim of this study was to evaluate the functional role of PP5 in osteosarcoma cells. Firstly, we found that PP5 is widely expressed in several human osteosarcoma cell lines. Then we used lentivirus-delivered siRNA to silence PP5 expression in Saos-2 and U2OS cell lines. Knockdown of endogenous PP5 expression by shRNA-expressing lentivirus significantly decreased the viability and proliferation of the osteosarcoma cells. Moreover, FACS analysis showed that knockdown of PP5 expression induced a significant arrest in the G0/G1 phase of the cell cycle, which was associated with the inhibition of cell proliferation. Therefore, knockdown of PP5 is likely to provide a novel alternative to targeted therapy of osteosarcoma and deserves further investigation.

Źródło:

Acta Biochimica Polonica; 2017, 64, 1; 11-16
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 19.

Tytuł:

Synthesis, immunosuppressive properties, mechanism of action and X-ray analysis of a new class of isoxazole derivatives

Autorzy:

Bąchor, Urszula
Ryng, Stanisław
Mączyński, Marcin
Artym, Jolanta
Kocięba, Maja
Zaczyńska, Ewa
Kochanowska, Iwona
Tykarska, Ewa
Zimecki, Michał

Powiązania:

https://bibliotekanauki.pl/articles/895268.pdf

Data publikacji:

2019-04-30

Wydawca:

Polskie Towarzystwo Farmaceutyczne

Tematy:

apoptosis
proliferation
isoxazoles
Passerini three-component reaction
Jurkat cells

Opis:

In the search for potential therapeutics, isoxazole derivatives are still objects of interest. Previously described immunoregulatory properties of 5-amino-3-methyl-4-isoxazolecarboxylic acid (AC) benzylamides prompted us to synthesize a new class of compounds of immunotropic activity. A series of new compounds containing the isoxazole moiety were synthesized using Passerini three-component reaction. The effects on phytohemagglutinin A (PHA)-induced proliferation of human peripheral blood mononuclear cells (PBMC), production of tumor necrosis factor alpha (TNF α) in human whole blood cultures stimulated with lipopolysaccharide (LPS) and two-way mixed lymphocyte reaction (MLR) of PBMC, were investigated. Also, the effect of 1-(cyclohexylcarbamoyl)cyclohexyl 5-amino-3-methylisoxazole-4-carboxylate (PUB1) on the expression of signaling molecules associated with cell apoptosis in Jurkat cells was also determined. The results showed that the compounds inhibited to various degree mitogen-induced PBMC proliferation in a dose-dependent manner and TNF α production at 10 μg/ml. PUB1 compound, selected on the basis of its strongest antiproliferative activity, was also shown to inhibit MLR. The molecular data suggest that immunosuppressive action of PUB1 depended on induction of Fas and elevation of caspase 8 expression. In summary, we revealed immunosuppressive properties of a new class of isoxazoles and established the mechanism of action of a representative PUB1 compound.

Źródło:

Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 2; 251-263
0001-6837
2353-5288

Pojawia się w:

Acta Poloniae Pharmaceutica - Drug Research

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 20.

Tytuł:

Current challenges to the non-proliferation regime: Iran and North Korea. A summary of professor Harnisch’ lecture

Autorzy:

Smolny, Dąbrówka

Powiązania:

https://bibliotekanauki.pl/articles/576183.pdf

Data publikacji:

2016-03-31

Wydawca:

Akademia Sztuki Wojennej

Tematy:

Non-Proliferation Regime
: Iran
North Korea
weapons of mass destruction

Źródło:

Security and Defence Quarterly; 2016, 10, 1; 21-34
2300-8741
2544-994X

Pojawia się w:

Security and Defence Quarterly

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 21.

Tytuł:

Clastogenic and toxicological assessment of cashew (Anacardium occidentale) nut bark extracts in Wistar rats

Autorzy:

Owumi, Solomon
Fatoki, John
Gbadegesin, Michael
Odunola, Oyeronke

Powiązania:

https://bibliotekanauki.pl/articles/1039006.pdf

Data publikacji:

2015

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Cashew bark oil
tattooing
toxicity
micronuclei
cell proliferation
skin cancer

Opis:

Occupational exposures to environmental toxicants have been associated with the onset of skin lesions-including cancers. Identification and reduction of exposure to such compounds is an important public health goal. We examined the effect of cashew shell oil (CSO), used in skin tattooing for its potential to induce skin transformation in rats. Corn oil and CSO (25, 50, and 100%) were topically applied to depilated sections of Wistar' rat skin (groups: I-IV) for six weeks. Effect of treatments on serum transaminases activity, histological changes in hepatocytes and induction of micronuclei in the bone marrow were examined. In addition, CSO-induced hepatocyte proliferation was also quantified. All animals survived the course of the study. Reduced percentage change in body weight and physical trauma were observed in CSO-treated rat. The effects were more prominent in Group IV (100% CSO). Relative liver weights and number of hepatocytes (cells/mm2) increased significantly in groups II-IV relative to control (p < 0.05). Serum transaminases activities were not significantly (p > 0.05) affected in treated groups. Hepatic histopathology revealed moderate sinusoidal congestion (group II), in addition to portal congestion in (group III), with mononuclear cellular infiltration (group IV) animals. In addition, CSO induced significant micronuclei formation of polychromatic erythrocyte (mPCEs) in the rat bone marrow (p < 0.05) when compared with control. Topical application of CSO disrupted skin cells integrity resulting in physical trauma. In addition, CSO appears to be clastogenic and induces hepatocyte proliferation. Occupational exposure to CSO especially for engraving tattoos in humans should be discouraged and further studies need to be conducted.

Źródło:

Acta Biochimica Polonica; 2015, 62, 3; 563-567
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 22.

Tytuł:

Evaluation of anticancer activity of water and juice extracts of young Hordeum vulgare in human cancer cell lines HT-29 and A549

Autorzy:

Czerwonka, Arkadiusz
Kawka, Katarzyna
Cykier, Klaudia
Lemieszek, Marta Kinga
Rzeski, Wojciech

Powiązania:

https://bibliotekanauki.pl/articles/989841.pdf

Data publikacji:

2017

Wydawca:

Instytut Medycyny Wsi

Tematy:

hordeum vulgare
colon cancer
lung cancer
inhibition of proliferation
necrosis

Opis:

Introduction and objective. Barley (Hordeum vulgare L.) is known as a rich source of different bioactive compounds. At present, considerable attention of researchers is focused on young barley grass. It can be a good source of dietary minerals, vitamins, carbohydrates, amino acids, phenolic compounds and proteins. It is possible that the composition of chemical ingredients beneficial for health may induce an anticancer potential of young barley in human colon adenocarcinoma (HT-29) and human lung adenocarcinoma (A549) cell lines. Materials and method. Hordeum vulgare water extract (HWE) and Hordeum vulgare juice extract (HJE) were prepared. Cell proliferation and viability were examined with the use of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and NR (neutral red) methods. Induction of necrosis was assessed by propidium iodide/Hoechst staining. Progress of the cell cycle involved in cell proliferation, apoptosis, and regulation of transcription was estimated using flow cytometry analysis. Additionally, the capability of free radical scavenging was evaluated with the DPPH assay. Results. The study revealed that extracts inhibited the proliferation of cancer cells. The NR study confirmed the low cytotoxic activity of the tested extracts to normal human colon epithelial cells (CCD 841 CoTr) and human skin fibroblasts (HSF). Furthermore, a dose-dependent cytotoxicity against HT-29 cells, but not A549 cells, has been reported. The free radical scavenging activity was observed in the case of the HWE but not the HJE. Conclusions. The obtained results indicate a cancer chemopreventive potential of young barley as a safe dietary agent in colon carcinoma.

Źródło:

Annals of Agricultural and Environmental Medicine; 2017, 24, 2
1232-1966

Pojawia się w:

Annals of Agricultural and Environmental Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 23.

Tytuł:

The Legality of the NATO Nuclear Sharing Program Under the Nuclear Non-Proliferation Treaty
Legalność programu udostępniania amerykańskiej broni jądrowej w świetle traktatu o nieproliferacji broni jądrowej

Autorzy:

Jembrzycki, Szymon

Powiązania:

https://bibliotekanauki.pl/articles/2139689.pdf

Data publikacji:

2020-11-30

Wydawca:

Wydawnictwo Naukowe Dolnośląskiej Szkoły Wyższej

Tematy:

broń jądrowa
NATO
nieproliferacja
denuklearyzacja.
nuclear weapon
non-proliferation
denuclearisation

Opis:

The paper analyzes the NATO Nuclear Sharing program, a “sharing” nuclear weapons program for part of the North Atlantic Treaty Organization (NATO) members. The studies’ goal is to depict the nature of the NATO Nuclear Sharing program and its legality under the Nuclear Non-Proliferation Treaty (NPT). Based on the studies’ main goal, the paper answers the following questions: what is the international non-proliferation regime, and what are the components? What are the NATO Nuclear Sharing program objectives, and can they violate the NPT? How does Donald Trump’s policy influence the present shape of the NATO Nuclear Sharing program? The theoretical part of the study was based on a review of literature, acts of international law, and military doctrine. It contributed to established the fact and correlation between this. Empirical research was conducted on the synthesis, which was used in formulated conclusions. The conclusions regarding the legality of the NATO Nuclear Sharing program under the NPT can be a field of study about the non-proliferation and denuclearisation issue. In conclusion, the main idea of the NATO Nuclear Sharing program is outdated. It is contributed to the wakening of efforts to non-proliferation and denuclearisation.
W artykule poddano analizie założenia amerykańskiego programu udostępniania broni jądrowej (NATO Nuclear Sharing) wybranym państwom Sojuszu Północnoatlantyckiego. Celem opracowania jest przedstawienie istoty programu udostępniania broni jądrowej oraz jego legalności względem traktatu o nieproliferacji broni jądrowej (NPT). W artykule, na podstawie przedstawionej literatury przedmiotu badań, udzielono odpowiedzi na następujące pytania: co to jest międzynarodowy reżim nieproliferacji broni jądrowej i jakie elementy go współtworzą? Jakie są założenia programu udostępniania broni jądrowej (NATO Nuclear Sharing) oraz czy naruszają one NPT? W jaki sposób polityka prowadzona przez Donalda Trumpa wpływa na obecny kształt programu NATO Nuclear Sharing? W opracowaniu jako metodę badawczą zastosowano analizę literatury, aktów prawa międzynarodowego oraz doktryny wojskowej, dzięki czemu ustalono fakty i zachodzące między nimi współzależności. Drugą z zastosowanych metod jest synteza, która pozwoliła na sformułowanie wniosków. Poruszone w artykule kwestie związane z istotą nieproliferacji broni jądrowej, a także programem udostępniania broni jądrowej stanowią płaszczyznę do dalszych i pogłębionych badań w zakresie nieproliferacji i denuklearyzacji broni jądrowej przez jej posiadaczy. Głównym wnioskiem wynikającym z opracowania jest przede wszystkim anachroniczność założeń programu udostępniania broni jądrowej, a tym samym podważenie działań nieproliferacji i denuklearyzacji broni jądrowej 

Źródło:

Rocznik Bezpieczeństwa Międzynarodowego; 2020, 14, 2; 263-276
1896-8848
2450-3436

Pojawia się w:

Rocznik Bezpieczeństwa Międzynarodowego

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 24.

Tytuł:

Effect of a static magnetic field on Saccharomyces cerevisiae growth in wastewater containing phenol and p-chlorophenol

Autorzy:

Rutkowska-Narożniak, Anna
Pajor, Elżbieta

Powiązania:

https://bibliotekanauki.pl/articles/2174350.pdf

Data publikacji:

2022

Wydawca:

Instytut Technologiczno-Przyrodniczy

Tematy:

p-chlorophenol
phenol
proliferation
Saccharomyces cerevisiae
static magnetic field
wastewater

Opis:

The effect of a static magnetic field (MF) of 7 mT with phenol (P) or p-chlorophenol (p-chP) concentrations of 100 mg∙dm-3 on the proliferation of Saccharomyces cerevisiae yeast was investigated. The abundance of the microorganism was determined under static culture conditions on a YPG medium with or without the addition of P or p-chP and exposed or unexposed to the MF over 48 h of the experiment. A static MF of 7 mT was shown to have a stimulating effect on S. cerevisiae cell proliferation after 24 h. It was proved that P and p-chP were used as an additional carbon source by yeasts. The greatest stimulation of the growth of the studied microorganisms was observed under the simultaneous effect of an MF and in presence of either P or p-chP. It was generally about 2 times higher at the time of the study than in the control. Statistical analysis of the results was carried out using, among other things, analysis of variance (ANOVA). A statistically significant difference in the growth of the tested microorganisms was observed. The study results indicate the possibility of applying an MF of 7 mT to enhance the process of phenol and p-chlorophenol removal from industrial wastewater.

Źródło:

Journal of Water and Land Development; 2022, 55; 178--184
1429-7426
2083-4535

Pojawia się w:

Journal of Water and Land Development

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 25.

Tytuł:

Molecular cloning, expression, purification and osteoblasts proliferation activity of sika deer thymosin beta10

Autorzy:

Zhao, D.
Zhao, Y.
Zhang, H.
Xu, Z.
Liu, M.
Wang, J.
Bai, X.

Powiązania:

https://bibliotekanauki.pl/articles/2087874.pdf

Data publikacji:

2017

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

affinity chromatography
cell proliferation
prokaryotic expression
sika deer
thymosin 10

Źródło:

Polish Journal of Veterinary Sciences; 2017, 4; 751-758
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 26.

Tytuł:

In vitro plant regeneration of Christmas cactus (Schlumbergera truncata (Haw.) Moran) by indirect morphogenesis

Autorzy:

Chornobrov, Oksana
Bilous, Svitlana

Powiązania:

https://bibliotekanauki.pl/articles/2041281.pdf

Data publikacji:

2021

Wydawca:

Instytut Badawczy Leśnictwa

Tematy:

Christmas cactus
nutrient medium
explant
callus
shoot proliferation
microclonal propagation

Opis:

Plants of Schlumbergera truncata (Haw.) Moran were obtained by indirect morphogenesis from the segment section of shoots in vitro, they were multiplied and rooted. Also were determined the effect of the lighting regime, the composition of the nutrient medium on the consistency and frequency of callus formation. The studies were conducted during 2016–2018. The mode of effective sterilization (more than 90%) of S. truncata plant explants using 0.1% HgCl2 for 7–8 min was established. Optimal conditions for the induction of callus formation in stem node segments of S. truncata plants (rate more than 90% and significant growth) were created on MS (Murashige and Skoog 1962) nutrient medium supplemented with 1.0 mg/l BAP (6-benzylaminopurine) and 0.3 mg/l NAA (1-naphthylacetic acid) under conditions of placement on the nutrient medium and doing a significant number of cuts on the explants. The light intensity of 2.0–3.0 klx, obtained by a callus of dense consistency of dark green pigmentation, when using the thermostat condition without illumination, the callus had loose consistency, dark yellow pigmentation. It is established that the influence of the lighting regime and the composition of the nutrient medium on the frequency of callus formation is statistically significant. The largest number of shoots was obtained on the MS medium with the addition of 2.0 mg/l of BA. At the same times, shoot proliferation and root induction in such numbers were observed on MS culture medium with the addition of 0.5 mg/l BA and 0.5 mg/l kinetin (multiplication factor – 8.8±0.6 per 60-day cultivation cycle).

Źródło:

Folia Forestalia Polonica. Series A . Forestry; 2021, 63, 1; 68-73
0071-6677

Pojawia się w:

Folia Forestalia Polonica. Series A . Forestry

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 27.

Tytuł:

Stanowisko Parlamentu Europejskiego wobec problemu proliferacji broni masowego rażenia i terroryzmu międzynarodowego

Autorzy:

Staszczyk, Artur

Powiązania:

https://bibliotekanauki.pl/articles/642021.pdf

Data publikacji:

2016

Wydawca:

Uniwersytet im. Adama Mickiewicza w Poznaniu

Tematy:

European Parliament
European Union
terrorism
proliferation
weapons of mass destruction

Opis:

The paper presents the stance of the European Parliament (EP) on the gravest threats to the security of the EU, in particular, the proliferation of weapons of mass destruction and the issue of international terrorism. Prevention of these threats lies predominantly within the competence of EU member states and its intergovernmental bodies. Such situation is implied by the fact that these issues fall within the scope of EU’s Common Foreign and Security Policy (CFSP) within which intergovernmental collaboration mechanisms play a dominant role. This means that the EP’s role in the shaping of EU’s policy on the prevention of weapons of mass destruction proliferation and international terrorism is limited and basically confined to the expression of non-binding opinions in its resolutions. However, relevant resolutions passed by the EP, though not binding in legal terms, have political significance and allow the EP, in contrast to other EU’s institutions, to articulate its position in an unequivocal and clear way. This is possible since the EP is the only supranational EU institution that has democratic legitimacy and can claim the right to exercise parliamentary control over the EU’s policy with respect to the prevention of the gravest threats to European security. This is particularly vivid as it comes to the fight against terrorism which is also the subject of interest for the common space of freedom, security and justice which employs intragovernmental collaboration mechanisms.

Źródło:

Przegląd Strategiczny; 2016, 9; 211-222
2084-6991

Pojawia się w:

Przegląd Strategiczny

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 28.

Tytuł:

Implikacje rozwoju cywilnej energetyki jądrowej dla europejskiego i światowego bezpieczeństwa
Implications of the Development of Civilian Nuclear Energy for European and Global Security

Autorzy:

Młynarski, Tomasz

Powiązania:

https://bibliotekanauki.pl/articles/489528.pdf

Data publikacji:

2016

Wydawca:

Polskie Towarzystwo Naukowe w Żytomierzu

Tematy:

climate policy
no emission
proliferation
dual use technology
nuclear weapons

Opis:

The article is an attempt to make an assessment of arguments for the development of civil nuclear power (non-carbon energy source) in the context of concerns on weakening the non-proliferation regime. The article analyzes dilemmas associated with the spread of civil nuclear power in the world and threats to international security (risk of utilization of dual-use technology for military purposes, trafficking of radioactive materials for the military or terrorists). Therefore, the key condition for the development of civil nuclear power is increasing the effectiveness of the NPT regime, including the acceptance of rigorous checks and inspections from IAEA officials by countries aspiring to join the nuclear program.

Źródło:

Studia Politologica Ucraino-Polona; 2016, 6; 152-161
2312-8933

Pojawia się w:

Studia Politologica Ucraino-Polona

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 29.

Tytuł:

Overexpression of human CUTA isoform2 enhances the cytotoxicity of copper to HeLa cells

Autorzy:

Yang, Jingchun
Li, Qiang
Yang, Huirong
Yan, Lichong
Yang, Liu
Yu, Long

Powiązania:

https://bibliotekanauki.pl/articles/1040764.pdf

Data publikacji:

2008

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

copper toxicity
CUTA isoform2
overexpression
copper-induced apoptosis
cell proliferation

Opis:

Copper, an essential transient element, can be toxic to cells when present in excess. Altered copper homeostasis is involved in pathological events of many diseases. Human CUTA isoform2 is a member of cation tolerance protein (CutA1) family. In this study, we examined the effect of CUTA isoform2 overexpression on copper toxicity. It was shown that overexpressed CUTA isoform2 sensitized HeLa cells to copper toxicity by promoting copper-induced apoptosis. The inhibition effect of excessive copper on cell proliferation was also enhanced by overexpressed CUTA isoform2. So CUTA isoform2 was implicated to be involved in the cytotoxicity of copper.

Źródło:

Acta Biochimica Polonica; 2008, 55, 2; 411-415
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 30.

Tytuł:

Thyroid hormones and their receptors in the regulation of cell proliferation

Autorzy:

Puzianowska-Kuznicka, Monika
Pietrzak, Maciej
Turowska, Olga
Nauman, Alicja

Powiązania:

https://bibliotekanauki.pl/articles/1041151.pdf

Data publikacji:

2006

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

thyroid hormone nuclear receptors (TRs)
oncoproteins
triiodothyronine (T3)
proliferation
mitogens

Opis:

In the present work, we have reviewed data showing that triiodothyronine and its nuclear receptors modify expression of different genes/proteins involved in cell cycle control beginning from growth factors (such as EGF and TGF-β), to cell surface receptors (EGFR), as well as proteins acting at the cell membrane (Ras), various transcription factors (c-Fos, c-Myc, E2F1), cyclins, Cip/Kip family of cdk2 inhibitors, and p53 inhibitor Mdm2 (Table 1). We have shown how TRs are also able to modify the fate of a cell, thanks to their ability to form complexes with other transcription factors such as p53 - a key regulator of apoptosis and proliferation. Available data show that the function of thyroid hormones and of their receptors on cell proliferation is not homogenous. In fact, it strongly depends on the cell type, its developmental state (progenitor or differentiated), its patho-physiological state (normal or tumor cell), and the so-called 'cellular context'. Therefore, it is not possible to uniformly recommend T3 treatment or T3 depletion to stop or initiate proliferation of all cell types. Instead, a very individual and careful action should be considered.

Źródło:

Acta Biochimica Polonica; 2006, 53, 4; 641-650
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 31.

Tytuł:

Inhibition of ehrlich ascites tumour (eat) cells proliferation through chitosan-mediated regulation of activity of the akt pathway

Autorzy:

Ignacak, Jan
Wiśniewska-Wrona, Maria
Dulińska-Litewka, Joanna
Pałka, Iwona
Kucharska, Magdalena

Powiązania:

https://bibliotekanauki.pl/articles/1035195.pdf

Data publikacji:

2014

Wydawca:

Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe

Tematy:

Akt kinase - PKB
EAT cells proliferation
M2 pyruvate kinase
chitosan

Opis:

Isoenzyme M2 pyruvate kinase, which is a marker of cancer transformation, can take both tetramer (cytosol) and dimer (nucleus) forms. The former is responsible for ATP synthesis, and the latter demonstrates histone H1 kinase activity. Regulation of the expression of pyruvate kinase through which Akt controls the expression of genes involved in Ehrlich ascites tumour (EAT) cell proliferation, migration and death, also involves cross-talk with the other signalling pathways, transcription factors and co-regulatory proteins such as β-catenin and c-Myc. Treatment of EAT cells with chitosans significantly reduced their proliferation (by 45-60%), expression of nuclear β-catenin, c-Myc as well as cell migration. After 48–72 hours of treatment of the cell with oligochitosans, lower levels of p-Akt were detected. Simultaneously, decreased expression of isoenzyme M2 PK protein levels was observed. The dimeric form (nucleus) can participate in H1 histone phosphorylation, which contributes to increased EAT cell proliferation.

Źródło:

Progress on Chemistry and Application of Chitin and its Derivatives; 2014, 19; 33-40
1896-5644

Pojawia się w:

Progress on Chemistry and Application of Chitin and its Derivatives

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 32.

Tytuł:

Proliferacja jako narzędzie podtrzymujące ewolucję człowieka w świetle poglądów Paula K. Feyerabenda z okresu umiarkowanego
Proliferation as a Factor Maintaining Human Evolution in the Light of Paul K. Feyerabend’s Early Philosophy

Autorzy:

Kilian, Krzysztof J.

Powiązania:

https://bibliotekanauki.pl/articles/553349.pdf

Data publikacji:

2013

Wydawca:

Uniwersytet Zielonogórski. Instytut Filozofii

Tematy:

Paul K. Feyerabend
proliferacja
uporczywość
kulturowa ewolucja
proliferation
tenacity
cultural evolution

Opis:

W umiarkowanym okresie swojej twórczości Feyerabend utrzymywał, że wzajemne oddziaływanie zasad proliferacji i uporczywości może przyspieszać pożyteczne biologicznie mutacje oraz może być jedynym dostępnym środkiem służącym do zapobiegania stagnacji naszego gatunku. Celem tego artykułu jest rekonstrukcja poglądów Feyerabenda na to zagadnienie oraz nadanie im określonej interpretacji, pozwalającej uniknąć pewnych problemów, do których te poglądy prowadzą. Przekonanie, że można przyspieszać biologicznie pożyteczne mutacje za pomocą formułowania i bronienia hipotez, sugeruje, przynajmniej na pierwszy rzut oka, podejście lamarkistowskie - teorię zmienności ukierunkowanej. Tę myśl Feyerabenda da się również rozumieć w duchu teorii zmienności nieukierunkowanej, a więc na modłę darwinowską, co sugeruje wyrażenie "może przyspieszać". Obydwa ujęcia prowadzą jednak do poważnych trudności. Lamarkistowskie uważane jest obecnie za błędne, zaś zgodnie z darwinowskim zmiany adaptacyjne zachodzą bardzo powoli. Biologicznie pożyteczne efekty współdziałania proliferacji i uporczywości pojawić się mogą po niesłychanie długim okresie czasu. Jego myśl, że wzajemne oddziaływanie proliferacji i uporczywości może być jedynym dostępnym środkiem zapobiegania stagnacji naszego gatunku najlepiej jest rozumieć w duchu kulturowej ewolucji człowieka, która ma charakter lamarkistowski.
In his early philosophy, Feyerabend claimed that the interaction between the principles of proliferation and tenacity may increase the tendency towards useful biological mutations. He also maintained that the interplay between the two principles may be the only possible way of preventing the human species from stagnation. I try to rectify some problems of Feyerabend’s approach. The claim that it is possible to increase the tendency towards useful biological mutations by means of generating and defending hypotheses seemingly implies Lamarckism, i.e. the theory of directed variation. However, it could also be incorporated into Darwinism, i.e. the theory of undirected variation (it is suggested by the phrase “may increase”). Both approaches lead to serious difficulties: Lamarckism is rejected by the mainstream biology; Darwinian adaptive changes are very slow. Biologically useful effects of interplay between proliferation and tenacity may come out after a very long time. Feyerabendian conviction that interaction between proliferation and tenacity may be the only possible way of preventing our species from stagnation should be understood in the light of human cultural evolution, and the latter is of course Lamarckian.

Źródło:

Filozoficzne Aspekty Genezy; 2013, 10; 179-202
2299-0356

Pojawia się w:

Filozoficzne Aspekty Genezy

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 33.

Tytuł:

Influence of vitamin D3 analogues in combination with budesonid R on proliferation of nasal polyp fibroblasts

Autorzy:

Rostkowska-Nadolska, Beata
Frączek, Marcin
Gawron, Wojciech
Latocha, Małgorzata

Powiązania:

https://bibliotekanauki.pl/articles/1040569.pdf

Data publikacji:

2009

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

vitamin D3
nasal polyps
tacalcitol
fibroblast
calcitriol
budesonid R
proliferation

Opis:

Vitamin D (VD) and its different analogues, besides their classic role as regulators of calcium and phosphor homeostasis, have emerged as a large family of antiproliferative agents. Such properties suggested VD potential as a therapy for chronic inflammatory diseases, including nasal polyposis (NP). NP growth involves both an inflammatory process and the proliferation of fibroblast as an important factor inducing aberrations in the phenotype of the epithelium. The aim of this study was to investigate the possible influence of 1α,25-dihydroxyvitamin D3 (calcitriol) and 1α,24(R)-dihydroxyvitamin D3 (tacalcitol) in monotherapy and in combination with budesonid R (BR) on NP fibroblast proliferation. Material and methods: The study involved 26 samples of NP. NP cells were cultured on 96-well plates beginning with a concentration of 5 × 103 cells per well with RPMI 1640 medium supplemented with antibiotics and 10% foetal bovine serum. After the fourth to sixth passage the medium was replaced with a nutrient medium with calcitriol or tacalcitol in a defined concentration (from 10-9 M to 10-3 M) alone or in combination with BR in 1:1, 1:3 or 3:1 ratios, each at concentrations from 10-5 M to 10-3 M. Results: Growth inhibition of nasal fibroblasts exposed to calcitriol or tacalcitol was noted. Significant antiproliferating activity was observed at calcitriol concentrations of 10-4 M and 10-3 M after 48 h, and at a concentration of 10-3 M after 72 h with the percentage of proliferating cells reduced to 30% compared to the control samples (P < 0.05). In cells treated with tacalcitol the maximal effect was seen at 10-4 M after 48 h and at 10-3M after 72 h with a 60% inhibition with respect to the control (P < 0.05). The inhibition of fibroblast proliferation reached the maximal level when they were exposed to calcitriol: BR (1 : 1) or tacalcitol: BR (1 : 1), each at a concentration of 10-4 M, after 72 h (82% and 69%, respectively). Conclusions: The antiproliferative activity of calcitriol and tacalcitol in NP cultures was confirmed. Because of its lower toxicity and higher activity tacalcitol seems to be the more promising agent in NP therapy, both as a single medication and in treatment protocols with BR.

Źródło:

Acta Biochimica Polonica; 2009, 56, 2; 235-242
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 34.

Tytuł:

Can transforming growth factor-β1 and retinoids modify the activity of estradiol and antiestrogens in MCF-7 breast cancer cells?

Autorzy:

Czeczuga-Semeniuk, Ewa
Anchim, Tomasz
Dzięcioł, Janusz
Dąbrowska, Milena
Wołczyński, Sławomir

Powiązania:

https://bibliotekanauki.pl/articles/1041552.pdf

Data publikacji:

2004

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

estradiol
apoptotic index
tamoxifen
TGF-β1
proliferation
MCF-7
retinoids

Opis:

Retinoic acid and transforming growth factor-β (TGF-β) affect differentiation, proliferation and carcinogenesis of epithelial cells. The effect of both compounds on the proliferation of cells of the hormone sensitive human breast cancer cell line (ER+) MCF-7 was assessed in the presence of estradiol and tamoxifen. The assay was based on [3H]thymidine incorporation and the proliferative activity of PCNA- and Ki 67-positive cells. The apoptotic index and expression of the Bcl-2 and p53 antigens in MCF-7 cells were also determined. Exogenous TGF-β1 added to the cell culture showed antiproliferative activity within the concentration range of 0.003-30 ng/ml. Irrespective of TGF-β1 concentrations, a marked reduction in the stimulatory action of estradiol (10-9 and 10-8 M) was observed whereas in combination with tamoxifen (10-7 and 10-6 M) only 30 ng/ml TGF-β1 caused a statistically significant reduction to aproximately 30% of the proliferative cells. In further experiments we examined the effect of exposure of breast cancer cells to retinoids in combination with TGF-β1. The incorporation of [3H]thymidine into MCF-7 cells was inhibited to 52 ± 19% (control =100%) by 3 ng/ml TGF-β1, and this dose was used throughout. It was found that addition of TGF-β1 and isotretinoin to the culture did not decrease proliferation, while TGF-β1 and tretinoin at low concentrations (3 × 10-8 and 3 × 10-7 M) reduced the percentage of proliferating cells by aproximately 30% (67±8% and 67±5%, P <0.05 compared to values in the tretinoin group). Both retinoids also led to a statistically significant decrease in the stimulatory effect of 10-9 M estradiol, attenuated by TGF-β1. In addition, the retinoids in combination with TGF-β1 and tamoxifen (10-6 M) caused a further reduction in the percentage of proliferating cells. Immunocytochemical analysis showed that all the examined compounds gave a statistically significant reduction in the percentage of cells with a positive reaction to PCNA and Ki 67 antigen. TGF-β1, isotretinoin and tretinoin added to the culture resulted in the lowest percentage of PCNA positive cells. However, the lowest fraction of Ki 67 positive cells was observed after addition of isotretinoin. The obtained results also confirm the fact that the well-known regulatory proteins Bcl-2 and p53 play an important role in the regulation of apoptosis in the MCF-7 cell line, with lowered Bcl-2 expression accompanying easier apoptotic induction. The majority of the examined compounds act via the p53 pathway although some bypass this important proapoptotic factor.

Źródło:

Acta Biochimica Polonica; 2004, 51, 3; 733-745
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 35.

Tytuł:

Proliferation and apoptosis of human T cells during replicative senescence - a critical approach.

Autorzy:

Jaruga, Ewa
Skierski, Janusz
Radziszewska, Ewa
Sikora, Ewa

Powiązania:

https://bibliotekanauki.pl/articles/1044352.pdf

Data publikacji:

2000

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

senescence
p16
CD25
apoptosis
T cells
proliferation
CD8

Opis:

Normal human T lymphocytes growing in culture undergo replicative senescence. Previously, we have shown that in our conditions polyclonal T cells cease proliferation after about three weeks (Radziszewska et al., 1999, Cell Biol. Int. 23, 97-103). Now we present results of a more detailed analysis of in vitro growth as well as phenotypic changes of T cells. Cell cycle analysis showed that about 20% of cells were in the S phase untill the 17th day of culture (young cells). The highest number of mitotic cells (phase G2/M; 10%) was observed during the first week of culture. All not dividing senescent cells were stopped in the G1 phase (after the 30th day of culture). The sub-G1 fraction which represents apoptotic cells did not exceed 8% during the whole period until the 30th day of culture. During in vitro T-cell growth, a rather rapid selection to CD3+CD8+ cells occurs. In the presenescent (between the 17th and 30th day) and senescent populations the majority of cells (above 90%) were CD8 positive. We also have checked the expression of α-chain interleukin-2 (IL-2) receptor (CD25). In young and presenescent cells about one third of cells was CD25 positive, but only 15% in the pool of senescent cells. Immunoblotting analysis of p16 protein recognized previously as a marker of senescent T cells, showed its highest and transient expression in presenescent cells. A critical review of the polyclonal T cell replicative senescence model is presented.

Źródło:

Acta Biochimica Polonica; 2000, 47, 2; 293-300
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 36.

Tytuł:

Does in vitro replicative senescence of human CD8+ cells reflect the phenotypic changes observed during in vivo ageing?

Autorzy:

Brzezinska, Agnieszka

Powiązania:

https://bibliotekanauki.pl/articles/1041348.pdf

Data publikacji:

2005

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

lymphocyte subpopulations
ageing
CD28
in vitro culture
proliferation
CD8

Opis:

Immunosenescence is viewed as a remodeling process with the exhaustion of naïve T cells and filling up of the immunological space with memory cells. In this study some phenotypic changes of CD8+ human cells during in vivo ageing were compared with those observed in long term cultures of lymphocytes derived from cord blood or from peripheral blood from donors of different age. Both in vivo and in vitro a significant decrease of the fraction of CD8+CD28+ cells was observed. Comparing the proportions of other T cell subpopulations (the CD4/CD8+ ratio, CD56, CD57, CD27) made it possible to conclude that replicative senescence in vitro partially reflects in vivo ageing.

Źródło:

Acta Biochimica Polonica; 2005, 52, 4; 931-935
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 37.

Tytuł:

Changes accompanying proliferative capacity and morphology of Nicotiana tabacum L. callus in response to 2,4-D
Zmiany związane ze zdolnością do proliferacji i morfologią kalusa Nicotiana tabacum L. w odpowiedzi na różne stężenia 2,4-D

Autorzy:

Gatz, Andrzej
Tomaszewska-Sowa, Agnieszka
Figas, Anna

Powiązania:

https://bibliotekanauki.pl/articles/1628038.pdf

Data publikacji:

2017

Wydawca:

Polskie Towarzystwo Botaniczne

Tematy:

Nicotiana tabacum
2
4-dichlorophenoxyacetic acid
proliferation
cell divisions
callus morphology

Opis:

The common trait of all auxins is a stimulation of cell elongation and also cell division in the presence of cytokinin; both are essential for callus induction and its multiplication. The response of plant tissues to various compounds with auxin activity may be quite different. In this study, the effectiveness of a synthetic auxin, 2,4-dichlorofenoxyacetic acid (2,4-D), instead of the generally applied natural auxin, indole-3-acetic acid (IAA), was tested for the proliferation of Nicotiana tabacum callus. The following concentrations of 2,4-D were tested: 0.1, 0.5, 1.0, 1.5, and 2.0 mg dm−3. Callus was derived from stem pith and its proliferation allowed on MS medium through five subcultures at 25°C and in darkness. After each passage, the fresh weight and morphological features of the callus were determined. The 0.5 mg dm−3 2,4-D treatment was the most favorable for producing the greatest increase in fresh weight in each of five subsequent subcultures as well as maintaining normal morphological features for proliferation. However, the 1.0 mg dm−3 2,4-D treatment in comparison with the lowest, 0.1 mg dm−3, was more beneficial when considering regular increases of fresh weight and a better cell cohesion for callus growth.
Do indukcji i namnażania kalusa niezbędne jest zastosowanie odpowiedniej auksyny, podanej samodzielnie lub z cytokininą. Spośród naturalnych auksyn IAA jest często wykorzystywana do stymulowania proliferacji kalusa Nicotiana tabacum. Zastosowanie IAA wymaga wyższych stężeń ze względu na nietrwałość, wynikającą z wrażliwości na światło i wysoką temperaturę. Takich ograniczeń nie posiada syntetyczna auksyna 2,4-D. Celem tej pracy była ocena przydatności 2,4-D do proliferacji kalusa Nicotiana tabacum z następującymi wariantami stężeń 0.1, 0.5, 1.0, 1.5 i 2 mg dm−3. Proliferację kalusa z rdzenia łodygi przeprowadzono na pożywce MS przez 5 pasaży bez dostępu światła i w temperaturze 25°C. Po każdym pasażu określono świeżą masę i cechy morfologiczne kalusa takie jak barwa, struktura powierzchni i stopień spójności komórek. Spośród badanych stężeń 2,4-D, najefektywniej stymulującym było 0.5 mg dm−3 ze względu na najwyższy przyrost świeżej masy w każdym z pięciu kolejnych pasaży oraz sprzyjające proliferacji cechy morfologiczne kalusa. Wariant stężenia 1.0 mg dm−3 2,4-D w porównaniu z 0.1 mg dm−3 okazał się korzystniejszy, ponieważ charakteryzował się regularnymi przyrostami i lepszą dla namnażania spójnością komórek kalusa.

Źródło:

Acta Agrobotanica; 2017, 70, 4
0065-0951
2300-357X

Pojawia się w:

Acta Agrobotanica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 38.

Tytuł:

Expression of IFN-λ1 from Congjiang pigs and its effect on anti-PRRSV proliferation

Autorzy:

Xin-qin, J.
Biao, W.
Zhi-qiang, D.
Yong, R.
Yan, H.
Meng-qiu, H.
Shan-shan, D.
Yu-jie, T.

Powiązania:

https://bibliotekanauki.pl/articles/2087291.pdf

Data publikacji:

2020

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

porcine ifn-λ1
porcine type III interferon
eukaryotic expression
anti-proliferation

Źródło:

Polish Journal of Veterinary Sciences; 2020, 23, 3; 423-430
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 39.

Tytuł:

Relationship between DNA replication and DNA repair in human lymphocytes proliferating in vitro in the presence and in absence of mutagen

Autorzy:

Szyfter, K
Wiktorowicz, K.
Wielgosz, M.S.
Zajaczek, S.
Kujawski, M.
Jaloszynski, P.
Czub, M.
Markowska, J.

Powiązania:

https://bibliotekanauki.pl/articles/2048210.pdf

Data publikacji:

1995

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

genotoxicity
DNA replication
human lymphocyte
DNA repair
lymphocyte proliferation
mutagenesis
in vitro

Opis:

The effects of mutagens on DNA replication and DNA repair were studied in peripheral blood lymphocytes (PBL) obtained from 21 healthy subjects, 2 samples from healthy heterozygote of Xeroderma pigmentosum (XP) and 2 samples from patient with clinically recognised XP. Inter-individual variations were found in DNA replication and in the level of spontaneous DNA repair measured under standard culture condition. Exposure of human PBL proliferating in vitro to B(a)P was followed by a partial inhibition of replicative DNA synthesis in all subjects and by an induction of DNA repair in healthy subjects. In XP patients DNA repair synthesis remained at the level attributed to spontaneous DNA repair. The response to mutagen varied individually. Results were analysed statistically. It was established that the studied indices of DNA synthesis correlate well with each other. The highest correlation was found between the levels of spontaneous and B(a)P-induced DNA repair. It is concluded that the level of spontaneous DNA repair is predictive for an estimation of cells ability to repair DNA damage. Inter-individual variations in the inhibition of DNA replication and in DNA repair synthesis are also dependent on the type of mutagen as shown by effects of other mutagens. Different effects of mutagen exposure on the inhibition of DNA replicative synthesis and induction of DNA repair can be explained by genetically controlled differences in the activity of enzymes responsible for mutagen processing and lesion removal.

Źródło:

Journal of Applied Genetics; 1995, 36, 4; 379-388
1234-1983

Pojawia się w:

Journal of Applied Genetics

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 40.

Tytuł:

In vitro propagation of Inula royleana DC.

Autorzy:

Stojakowska, A
Malarz, J.

Powiązania:

https://bibliotekanauki.pl/articles/58750.pdf

Data publikacji:

2004

Wydawca:

Polskie Towarzystwo Botaniczne

Tematy:

Inuleae
Compositae
herb
shoot proliferation
axillary shoot
micropropagation
medicinal plant
Inula royleana

Opis:

A micropropagation method, through axillary shoot proliferation, was elaborated for Inula royleana DC. (Asteraceae), a medicinal plant native of Himalaya. Primary explants (cotyledonary node explants) and secondary explants (node explants of in vitro regenerated shoots) of the plant, inoculated on MS medium supplemented with 0.1 μM NAA and 5.0 μM kinetin, regenerated 3.4 ± 1.2 and 5.1 ± 1.9 axillary shoots per explant, respectively. The regenerated shoots were easily rooting and adapting to growth in soil.

Źródło:

Acta Societatis Botanicorum Poloniae; 2004, 73, 1
0001-6977
2083-9480

Pojawia się w:

Acta Societatis Botanicorum Poloniae

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 41.

Tytuł:

Changes in the pathomorphological diagnosis of gastrointestinal neuroendocrine neoplasms in 2017

Autorzy:

Nasierowska-Guttmejer, Anna

Powiązania:

https://bibliotekanauki.pl/articles/1062924.pdf

Data publikacji:

2017

Wydawca:

Medical Education

Tematy:

G3 NET
Ki-67 proliferation index
NEC
neuroendocrine carcinoma
neuroendocrine tumors

Opis:

The following changes were introduced in 2017 WHO and TnM classifications: 1. a new group of well-differentiated neuroendocrine tumors with the proliferation index of more than 20% and mitotic count of 20 per 10 hpf (NET G3), formerly classified under neuroendocrine carcinomas (NEC G3) 2. the division of poorly differentiated neuroendocrine tumors (PD NET) with the Ki-67 index of more than 20% into two groups in terms of the degree of differentiation and prognosis: NET G3 and NEC. 3. the replacement of MANEC with MINEN within the mixed group 4. the verification of histological grading (G) criteria 5. new TNM staging criteria, based on ENETS guidelines.

Źródło:

OncoReview; 2017, 7, 3; 109-115
2450-6125

Pojawia się w:

OncoReview

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 42.

Tytuł:

Effect of 2iP and NAA on shoot induction and proliferation in micropropagated willow herb (Chamaenerion angustifolium (L.) Scop.)

Autorzy:

Dreger, M.
Wielgus, K.

Powiązania:

https://bibliotekanauki.pl/articles/951270.pdf

Data publikacji:

2015

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

Chamaenerion angustifolium
Epilobium angustifolium
Onagraceae
medicinal plant
willow herb
micropropagation
shoot induction
proliferation

Źródło:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 1
0860-7796

Pojawia się w:

BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 43.

Tytuł:

The role of oligochitosans in akt kinase regulation

Autorzy:

Ignacak, Jan
Wiśniewska-Wrona, Maria
Dulińska-Litewka, Joanna
Pałka, Iwona
Kucharska, Magdalena

Powiązania:

https://bibliotekanauki.pl/articles/1034912.pdf

Data publikacji:

2015

Wydawca:

Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe

Tematy:

Akt kinase – PKB
EAT cells proliferation
HIF-1 factor.
M2 pyruvate kinase

Opis:

Among characteristic properties of cancers, there is their increased glycolytic activity.Contrary to normal cells, neoplastic cells use anaerobic glycolysis, even when a sufficient amount of oxygen is available. The intensity of the process is associated with a considerable demand for energy in the form of ATP. Akt, which - acting through the mTOR pathway - activates the HIF-1 factor, which in turn activates hexokinase that participates in glucose phosphorylation, stimulates the transport of glucose to cells via increasing glucose transporters (GLUT) and activates lactate dehydrogenase (which transforms pyruvate to lactate). Chitosan, as well as products of its degradation - oligochitosans - contribute to inhibiting the activity of the Akt kinase, and thus contribute to inhibiting excessive glycolytic activity of Ehrlich ascites tumor (EAT) cells and to decreasing proliferation of these cells.

Źródło:

Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 73-81
1896-5644

Pojawia się w:

Progress on Chemistry and Application of Chitin and its Derivatives

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 44.

Tytuł:

Effect of plant growth regulators and explant types on induction and growth of callus of Primula veris L.
Wpływ regulatorów wzrostu i rodzaju eksplantatów na indukcję kalusa i wzrost pierwiosnka lekarskiego (Primula veris L.)

Autorzy:

Morozowska, M.
Wesolowska, M.
Glowicka-Woloszyn, R.
Kosinska, A.

Powiązania:

https://bibliotekanauki.pl/articles/72672.pdf

Data publikacji:

2013

Wydawca:

Instytut Włókien Naturalnych i Roślin Zielarskich

Tematy:

plant growth
growth regulator
explant type
callus induction
growth
callus
Primula veris
proliferation

Opis:

Primula veris L. (Primulaceae) is a well-known medicinal herb. The callus induction response of three explant types: roots, cotyledons, and hypocotyls of four-week-old cowslip seedlings were evaluated. The highest statistically different callus induction rate was 93.6% and was obtained from root explants on MS medium supplemented with 0.1 mg/l BA and 5.0 mg/l PIC. Calli also appeared on 83.3% of cotyledon explants on MS medium supplemented with 1.0 mg/l BA and 3.5 mg/l 2,4-D and on 81.0% of root explants on MS medium supplemented with 0.1 mg/l KIN and 2.0 mg/l 2,4-D. These values were not statistically different. The average time required for callus initiation was 4 to 6 weeks, however, it depended on the explants type. The most suitable condition for callus proliferation and growth was MS medium with 0.5 mg/l TDZ and 0.1 mg/l NAA, and with 1.0 mg/l BA and 2.0 mg/l or 3.5 mg/l 2,4-D. No light conditions proved to be more favourable for cowslip calli induction and growth.
Primula veris L. (Primulaceae) to znana roślina lecznicza. Opracowano metodę otrzymywania in vitro tkanki kalusowej z trzech rodzajów eksplantatów: korzeni, liścieni i hypokotyli z czterotygodniowych siewek pierwiosnka lekarskiego. Najwyższy, istotny statystycznie i wynoszący 93,6% indukcji tkanki kalusowej uzyskano z eksplantatów korzeniowych na podłożu Murashige i Skooga (MS) zawierającego 0,1 mg/l BA i 5,0 mg/l PIC. Indukcję kalusa obserwowano także na 83,3% eksplantatów liścieniowych na pożywce MS uzupełnionej 1,0 mg/l BA i 3,5 mg/l 2,4-D oraz na 81,0% eksplantatów korzeniowych na pożywce MS zawierającej 0,1 mg/l KIN i 2,0 mg/l 2,4-D. Średni czas potrzebny do inicjacji kalusa wyniósł 4 do 6 tygodni i zależał od rodzaju eksplantatu. Podłoża MS uzupełnione 0,5 mg/l TDZ i 0,1 mg/l NAA oraz 1,0 mg/l BA i 2,0 mg/l lub 3,5 mg/l 2,4-D okazały się najodpowiedniejszymi dla dalszego rozwoju i wzrostu zregenerowanej tkanki kalusowej. Warunki bez dostępu światła były korzystniejsze dla indukcji i wzrostu tkanki kalusowej pierwiosnka lekarskiego.

Źródło:

Herba Polonica; 2013, 59, 3
0018-0599

Pojawia się w:

Herba Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 45.

Tytuł:

Chemical modification of poly ε-caprolactone with wollastonite and its influence on biological properties of osteoblast like-cells MG-63

Autorzy:

Ścisłowska-Czarnecka, A.
Menaszek, E.
Kołaczkowska, E.
Błażewicz, M.
Podporska, J.

Powiązania:

https://bibliotekanauki.pl/articles/284898.pdf

Data publikacji:

2011

Wydawca:

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów

Tematy:

polycaprolactone
wollastonite
osteoblast-like MG-63 cells
cell adhesion
viability
proliferation
alkaline phosphatase

Opis:

PCL (poly-ε-caprolactone) is a biocompatible and biodegradable polymer of aliphatic polyester group. However, PCL does not effectively bind to the bone in contrast to bioactive inorganic compounds such as wollastonite. For this wollastonite (WS) is regarded as a potential bioactive material for bone tissue engeenering although its main drawback is brittlennes. Therefore we synthesized polymer nanocomposite materials composed of poly-ε-caprolactone and wollastonite (PCL/wollastonite) containing either 0.5% or 5% of the latter modifying filler. And we aimed to verify biological properties of the nanocomposite PCL/WS materials, in comparison to the pure PCL, on cultures of osteoblast-like cells MG-63. The study revealed that the adherence of the osteoblast-like cells to the tested materials was enhanced by the PCL modification (PCL/5WS > PCL/0.5WS > PCL) while cell viability/proliferation was not altered. Furthermore, the activity of alkaline phosphatase indicative of osteoblast differentiation (maturation) was enhanced when the cells were cultured with either PCL/5WS or PCL/0.5WS. Overall, our results indicate that PCL-modified wollastonite improves biological properties of the basic biomaterial suggesting its potential usefulness/application for the bone tissue regeneration.

Źródło:

Engineering of Biomaterials; 2011, 14, 102; 11-14
1429-7248

Pojawia się w:

Engineering of Biomaterials

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 46.

Tytuł:

Improvement of growth parameters of prune callus cultures destined to initiate cell suspensions

Autorzy:

Hanus-Fajerska, E

Powiązania:

https://bibliotekanauki.pl/articles/57881.pdf

Data publikacji:

2006

Wydawca:

Polskie Towarzystwo Botaniczne

Tematy:

improvement
growth parameter
prune
callus culture
cell suspension
Prunus domestica
growth regulator
proliferation

Opis:

Callus was inducted on wounded leaf explants from shoot tips of a particular Prunus domestica 'Węgierka Zwykła' clone cultivated in vitro. The improvement of Sweet Common Prune stock callus tissue parameters has been approached by experiments on culture protocols. Either for the induction or maintenance of tissue modified Murashige and Skoog medium, supplemented with different auxins and cytokinins at varying concentrations, was used. The goal was to obtain the highiest possible proliferative capacity of friable tissue without any signs of cell redifferentiation for about 10 weeks. The choice of auxin was an important factor regulating the rate and kind of tissue growth, and for the examined prune clone auxin alone brought a relatively small proportion of cells into division, so advantageous was to combine it with oxygenated cytokinin. Friable tissue was obtained on media supplemented with dicamba or with picloram, but not with 2.4-D neither alone nor combinated with IBA.

Źródło:

Acta Societatis Botanicorum Poloniae; 2006, 75, 1; 5-9
0001-6977
2083-9480

Pojawia się w:

Acta Societatis Botanicorum Poloniae

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 47.

Tytuł:

Role of chitosan oligomers in regulation of ehrlich ascites tumor cells proliferation in vitro

Autorzy:

Ignacak, Jan
Wiśniewska-Wrona, Maria
Pałka, Iwona
Zagajewski, Jacek
Niekraszewicz, Antoni

Powiązania:

https://bibliotekanauki.pl/articles/1035427.pdf

Data publikacji:

2011

Wydawca:

Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe

Tematy:

EAT cells proliferation
L-S-nitrosocysteine.
chitosan oligomers
pyruvate kinase M2 isoenzyme

Opis:

Preliminary studies of proliferation of Ehrlich ascites tumor (EAT) cells and normal mammary gland epithelial cells have demonstrated the process to be inhibited by degradation products of microcrystalline chitosan, i.e. oligomers. Inhibition of proliferation has been also accompanied by a decreased activity of the M2 pyruvate kinase (PK) isoenzyme in nucleoplasm, what may indicate the role of this enzyme in regulation of tumor cell proliferation. Determinations of nitrogen oxide in tumor and normal cells point to a higher level of this endogenous effector in normal cells. An increase of nitrogen oxide levels in Ehrlich ascites tumor cells effected by chitosan oligomers may indicate increased nitrosylation, and particularly an increased amount of compounds containing sulfhydryl groups and their participation in regulation of nucleoplasm M2 PK isoenzyme activity. Chitosan oligomers have smaller molecules as compared to microcrystalline chitosan and for this reason appear to be more effective than the latter in acting upon the negatively charged cell membrane surfaces, thus contributing to proliferation inhibition.

Źródło:

Progress on Chemistry and Application of Chitin and its Derivatives; 2011, 16; 89-98
1896-5644

Pojawia się w:

Progress on Chemistry and Application of Chitin and its Derivatives

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 48.

Tytuł:

17 beta-estradiol affects proliferation and apoptosis of canine bone marrow mesenchymal stem cells in vitro

Autorzy:

Zhou, Z.-H.
Gu, C.-W.
Li, J.
Huang, X.-Y.
Deng, J.-Q.
Shen, L.-H.
Cao, S.-Z.
Deng, J.-L.
Zuo, Z.-C.
Wang, Y.
Ma, X.-P.
Ren, Z.-H.
Yu, S.-M.

Powiązania:

https://bibliotekanauki.pl/articles/2087308.pdf

Data publikacji:

2020

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

apoptosis
bone marrow mesenchymal stem cells (BMSCs)
canine
proliferation
17 beta-estradiol (E2)

Źródło:

Polish Journal of Veterinary Sciences; 2020, 23, 2; 235-245
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 49.

Tytuł:

EFEKTYWNOŚĆ MIĘDZYNARODOWYCH REŻIMÓW NIEPROLIFERACJI BRONI BIOLOGICZNEJ I CHEMICZNEJ
THE EFFICIENCY OF INTERNATIONAL BIOLOGICAL AND CHEMICAL WEAPONS NON-PROLIFERATION REGIMES

Autorzy:

Stempień, Marta
Tołwiński, Maciej

Powiązania:

https://bibliotekanauki.pl/articles/513469.pdf

Data publikacji:

2015

Wydawca:

Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego

Tematy:

non-proliferation
international agreements
international control
dis-armament
biological weapons
chemical weapons
international regimes

Opis:

International non-proliferation regimes will only be effective when the efforts of the signatories of international agreements, regional or bilateral will be increased, because declarative expression of support for the various forms of initiatives of the international community often end up at this level, as shown by the cases of chemical weapons use in the Syrian Civil War. The main aim of this article is to show the management problems of global non-proliferation regimes of biological and chemical weapons. The authors made a comparative analysis of two non-proliferation regimes. This combination helped to achieve the second objective of the article, which is to identify the major challenges and threats generated by these regimes, which allowed the formulation of the conclusion that in order to strengthen them, the international community must take comprehensive action, including reducing the threat of terrorist organizations.

Źródło:

Polityka i Społeczeństwo; 2015, 13, 4; 115-133 (19)
1732-9639

Pojawia się w:

Polityka i Społeczeństwo

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 50.

Tytuł:

T-cell proliferation on immunopathogenic mechanism of psoriasis: a control based theoretical approach

Autorzy:

Datta, A.
Roy, P. K.

Powiązania:

https://bibliotekanauki.pl/articles/205612.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Instytut Badań Systemowych PAN

Tematy:

T-cells
dendritic cells
keratinocytes
dermis
epidermis
cytokines
T-cell proliferation
drug efficacy
optimal control

Opis:

Psoriasis vulgaris is a common, worldwide autoimmune skin disorder characterized by T-cells mediated hyperproliferation of keratinocytes. The feature of T-cells arbitrated psoriatic lesions is the epidermal infiltration of oligoclonal CD8⁺ T-cells and also of CD4⁺ T-cells in the dermis. Psoriatic scratches are identified by red and enlarged lesions along with silver whitish scales. In this article, we propose a mathematical model for psoriasis, involving a set of differential equations, concerning T-cells, dendritic cells and epidermal keratinocytes. We introduce T-cell proliferation in the system, where T-cells are generated through expansion of accessible CD4⁺ T-cells from precursors. We are interested in observing how the cell biological system develops through T-cell proliferation in presence of control with respect to T-cells and keratinocytes. We study the model in both implicit and explicit ways and measure the effect of drug on the system through impulsive drug therapy.

Źródło:

Control and Cybernetics; 2013, 42, 2; 365-386
0324-8569

Pojawia się w:

Control and Cybernetics

Dostawca treści:

Biblioteka Nauki

/5

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