Temat: Proliferation - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Higher Apoptosis Index and Proliferation Index in Colonocytes of Patients with Ulcerative Colitis in Remission
Autorzy:: Buczyński, Jarosław
Spychalski, Michał
Ławska-Wierzchniewska, Agnieszka
Dziki, Adam
Powiązania:: https://bibliotekanauki.pl/articles/1396694.pdf
Data publikacji:: 2012-06-01
Wydawca:: Index Copernicus International
Tematy:: apoptosis
proliferation
ulcerative colitis
Opis:: Ulcerative colitis (UC) is a inflammatory disease of large bowel. The amount of people suffering from UC increases from year to year. Pathogenesis of this affection is still not entirely clear. Mechanisms of proliferation and apoptosis in colonocytes in the course of the disease are defectedThe aim of the study was to assess the rate of proliferation and intensity of apoptosis in colonocytes in patients with diagnose UC.Material and methods. Colon pathological samples taken from patients with diagnosed ulceraive colitis were examined. Patients were in both clinical and endoscopic remission and were treated with mesalazin. They were patient of Department of General and Colorectal Surgery. To estimate proliferation index dye with monoclonal antibody against Ki67. To determine apoptosis level immunohistochemistry with antybody against Bax was used.Results. Average Ki-67 in the test group was 42,13%, the largest value amounted to 57% and the lowest of 33%. Average value of Bax was 1.47 and ranged between 0-3. High index of bax appear not only in the bottom of the crypt, but also at their outlet.Conclusions. In ulecerative colitis genetic and immunological disturbances occur despite treatment. Mesalazine acting only on certain routes associated with the UC holds the remission, without, however "the molecular remission". Thus, it appears that the results of our research are another proof of the necessary caution in weaning support treatment.
Źródło:: Polish Journal of Surgery; 2012, 84, 6; 271-275
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: The influence of fractionated radiation on proliferation, cell cycle and apoptosis of normal human dermal fibroblasts
Autorzy:: Adamczyk, A.
Gasińska, A.
Powiązania:: https://bibliotekanauki.pl/articles/147800.pdf
Data publikacji:: 2005
Wydawca:: Instytut Chemii i Techniki Jądrowej
Tematy:: fibroblasts
fractionated irradiation
proliferation
radiosensitivity
Opis:: The aim of the study was to investigate the changes in proliferation rate, cell cycle and apoptosis of normal skin fibroblasts during fractionated irradiation with a fraction dose of 2 Gy. Fibroblasts were irradiated 5 days per week for 12 days using gamma irradiation. Twenty four hours after each fraction, and for three days after finishing experiment the cells were harvested, fixed, and BrdUrd labelling index (BrdUrdLI), cell cycle and level of apoptosis and debris were assessed. It was found that fractionated irradiation caused disturbances in the proliferation rate and the cell cycle. Irradiation caused also constant, statistically significant increase in the number of G2M cells and level of apoptosis and debris, which was observed even during 3 days after irradiation. Data indicate non equal biological effect of each fraction dose. Block at G2/M phase suggests accumulation of sublethal damage and increased radiosensitivity, which was manifested by elevated level of cell death (apoptosis and debris).
Źródło:: Nukleonika; 2005, 50,suppl.2; 9-12
0029-5922
1508-5791
Pojawia się w:: Nukleonika
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Proliferation of Democratic Education in Indonesia: The Influence Measurement of Tolerance, Multiculturalism, and Historical Awareness on the Democratic Attitude
Autorzy:: Sumardjoko, Bambang
Joebagio, Hermanu
Sariyatun, -
Powiązania:: https://bibliotekanauki.pl/articles/1969412.pdf
Data publikacji:: 2018-06-30
Wydawca:: Wydawnictwo Adam Marszałek
Tematy:: democratic education
proliferation
democratic attitude
Opis:: This research aims to predict the direction of democratic education in Indonesia through the influence measurement of tolerance, multicultural sensitivity, and historical awareness of the democratic attitude. The multiple linear regression test, coefficient determination test, and model accuracy test were used to measure the influence of the predictors and the dependent variable. The research participants were 300 students, aged between 17 and 18 years, who were taken proportionally in Senior High School (SHS) 1 Surakarta, SHS 5 Surakarta, and SHS 6 Surakarta. Results showed a simultaneous and partial influence of tolerance, multicultural sensitivity, and historical awareness on the democratic attitude. The authors found that there is no diversion in the proliferation of democratic education in Indonesia, in which tolerance, multicultural sensitivity, and historical awareness have a positive influence on the democratic attitude. However, the authors stated that the association between tolerance and democratic education in Indonesia remains problematic, thus, it should be noticed in future research.
Źródło:: The New Educational Review; 2018, 52; 112-123
1732-6729
Pojawia się w:: The New Educational Review
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Pakistański program nuklearny w kontekście typologii modeli proliferacji Scotta D. Sagana
Pakistani Nuclear Program in the context of Scott D. Sagan’s Models of Nuclear Proliferation
Autorzy:: Kopeć, Rafał
Powiązania:: https://bibliotekanauki.pl/articles/1953231.pdf
Data publikacji:: 2015-06-30
Wydawca:: Wydawnictwo Adam Marszałek
Tematy:: proliferation
security model
nuclear program
Opis:: The aim of the paper is to present the Pakistani nuclear program in the context of Scott D. Sagan’s models describing the causes of nuclear weapons proliferation. The typology consists of three models: the security, the domestic policy, and the norms. The author claims that the Pakistani program would be the most adequately present using the security model. The program was a response to both conventional and nuclear threat from India, which has been in permanent conflict with Pakistan.
Źródło:: Athenaeum. Polskie Studia Politologiczne; 2015, 46; 147-160
1505-2192
Pojawia się w:: Athenaeum. Polskie Studia Politologiczne
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: PEGYLATED GEMCITABINE AND METHOTREXATE: IN VITRO CYTOTOXICITY ANALYSIS AND IN VIVO DRUG RELEASE PROFILING TO ASSESS THEIR ENHANCED BLOOD CIRCULATION
Autorzy:: Ahmed, Mahmood
Powiązania:: https://bibliotekanauki.pl/articles/895274.pdf
Data publikacji:: 2019-08-30
Wydawca:: Polskie Towarzystwo Farmaceutyczne
Tematy:: drug delivery
anti-proliferation
Pegylation
spheroids
Opis:: In the present study, four new pegylated drugs were synthesized to investigate the anticancer activity. All the compounds were characterized on the basis of FTIR and 1HNMR. The new compounds were evaluated against HCT116 cell line by CellTiter-Glo® 3D cell viability assay. The sustained release pattern of newly synthesized compounds were also evaluated, slow released lasts for 240 h which was confirmed by in vivo and in vitro drug release profile. The sustained and controlled release behavior of pegylated drugs over the extended period of time showed a linear profile and this release pattern was not limited to diffusion process instead supporting chemically controlled release pattern which was dependent only on how fast the compound hydrolyzed. The newly designed pegylated drugs showed almost same killing effect against the cancer cells as the free drugs. The compounds with lower cLogP value showed more antiproliferative (lower IC50) effect due their higher cell permeability.
Źródło:: Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 4; 653-659
0001-6837
2353-5288
Pojawia się w:: Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: A novel polypeptide from Cervus nippon Temminck proliferation of epidermal cells and NIH3T3 cell line
Autorzy:: Guan, Shu-Wen
Duan, Leng-Xin
Li, Yuan-Yuan
Wang, Ben-Xiang
Zhou, Qiu-Li
Powiązania:: https://bibliotekanauki.pl/articles/1041255.pdf
Data publikacji:: 2006
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: polypeptide
velvet antler
promoting cell proliferation
Opis:: A novel polypeptide, velvet antler polypeptide (VAPPs), having a stimulary effect on proliferation of some cell was isolated from the velvet antler of sika deer (Cervus nippon Temminck). This polypeptide consists of a single chain of 32 amino-acid residues VLSAT DKTNV LAAWG KVGGN APAFG AEALE RM. VAPPs showed marked stimulary effect on rat epidermal cells and NIH3T3 cell line (dose range from 10-40 mg·L-1 and 5-80 mg·L-1, respectively).
Źródło:: Acta Biochimica Polonica; 2006, 53, 2; 395-397
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Socialisation of International Rules. Exploring Alternative Mechanisms for Securing Compliance with International Humanitarian Law by Armed Groups
Uspołecznianie międzynarodowych zasad. Badanie alternatywnych mechanizmów dla gwarantowania zgodności z międzynarodowym prawem humanitarnym (IHL) w działaniu ugrupowań zbrojnych
Autorzy:: cholewinska, agnieszka j.
Powiązania:: https://bibliotekanauki.pl/articles/2141079.pdf
Data publikacji:: 2019-12-26
Wydawca:: Wydawnictwo Naukowe Dolnośląskiej Szkoły Wyższej
Tematy:: proliferation
socialization
international humanitarian law (IHL)
Opis:: Proliferation of internal armed conflicts poses a challenge to the framework of international humanitarian law (IHL) as it was primarily designed to guide states’ behaviour while at war. Are the existing mechanisms available under IHL sufficient to ensure compliance with the law by armed groups? The purpose of this article is to examine how socialisation, by which I mean a process of internalising a norm or a rule so that external pressure is no longer necessary to ensure compliance, might contribute to producing long-term rule-consistent behaviour. I begin with the identification of the legal framework applicable to internal conflicts and challenges associated with its implementation. Following is the discussion of the ideas on socialisation and their utility in the context of IHL and armed groups. I then proceed to present a particular example of positive engagement with such groups under the so-called Deed of Commitment, launched by a Swiss NGO, Geneva Call. Finally, I return to my analytical framework, apply it to the system established under the Deed of Commitment, and assess to what extent socialisation and positive engagement may ensure greater respect for humanitarian rules. I conclude that socialisation is a valuable tool that may complement the existing mechanisms under IHL and, under certain conditions, contribute to long-term rule-consistent behaviour.
Rozprzestrzenianie się międzynarodowych konfliktów zbrojnych gromadzi wyzwania dla zakresu oddziaływania międzynarodowego prawa humanitarnego (IHL), którego założycielską ideą było kształtowanie zasad zachowania państw w czasie wojen. Dlatego należy zadać pytanie, czy istniejące mechanizmy w zakresie międzynarodowego prawa humanitarnego (IHL) są wystarczające, aby zapewnić zgodność w zakresie prawnym w odniesieniu do funkcjonowania ugrupowań zbrojnych? Ideą tego artykułu jest zbadanie, jak uspołecznienie, prze która autorka postrzega proces umiędzynarodowienia zasad lub reguł, tak aby zewnętrzny wpływ nie był dalej konieczny, w zapewnieniu zgodności, co w perspektywie może być źródłem do tworzenia długoterminowych spójnych zasad zachowań. We wstępie artykułu wyszczególniono ramy prawne mające zastosowanie w konfliktach zbrojnych oraz wyzwań towarzyszących ich wdrażaniu. W dalszych rozważania jest prezentowana dyskusja koncepcji uspołeczniania oraz jej przydatność w kontekście międzynarodowego prawa humanitarnego (IHL) oraz działania ugrupowań zbrojnych. W dalszej części autorka przechodzi do prezentowania wybranych przykładów pozytywnej współdziałania z takimi ugrupowaniami w ramach tzw.„Deed of Commitment”, czyli inicjatywa aktów dobrej woli zorganizowana przez Szwajcarskie Organizacje Pozarządowe (NGOs), Geneva Calls. Ostatecznie autorka powraca do analitycznego obszaru badawczego i odnosi wyniki badan do ram działań w systemie ustanowionym przez „Deed of Commitment”, aby ostatecznie ocenić w jakim zakresie uspołecznienie oraz pozytywne zaangażowanie mogą zapewnić większe zrozumienie dla stosowania humanitarnych zasad. W podsumowaniu, stwierdza się, że uspołecznienie jest znakomitym narzędziem, który może uzupełniać mechanizmy funkcjonowania międzynarodowego prawa humanitarnego (IHL) oraz w szczególnych warunkach wnosić wartość dodaną do długoterminowych spójnych zasad zachowań.
Źródło:: Rocznik Bezpieczeństwa Międzynarodowego; 2013, 7; 317-336
1896-8848
2450-3436
Pojawia się w:: Rocznik Bezpieczeństwa Międzynarodowego
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Antigen-specific lymphocyte proliferation as a marker of immune response in guinea pigs with sustained Helicobacter pylori infection
Autorzy:: Miszczyk, Eliza
Walencka, Maria
Rudnicka, Karolina
Matusiak, Agnieszka
Rudnicka, Wiesława
Chmiela, Magdalena
Powiązania:: https://bibliotekanauki.pl/articles/1039292.pdf
Data publikacji:: 2014
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Helicobacter pylori
T cells
proliferation
guinea pigs
Opis:: Helicobacter pylori (H. pylori) bacteria are human pathogens causing symptomatic gastritis, peptic ulcer or gastric cancer. Little is known about the kinetics of immune responses in H. pylori infected patients because the initial moment of infection has not been identified. Various animal models are used to investigate the immune processes related to H. pylori infection. In this study we checked whether H. pylori infection in guinea pigs, mimicking natural H. pylori infection in humans, resulted in the development of specific immune responses to H. pylori antigens by measuring the proliferation of lymphocytes localized in mesenteric lymph nodes, spleen and peripheral blood. The maturity of macrophages and cytokines, delivered by monocyte-macrophage lineage or lymphocytes, were considered as mediators, which might influence the lymphocyte blastogenic response. The obtained results showed the activation of T cells localized in mesenteric lymph nodes by H. pylori antigens in H. pylori infected guinea pigs four weeks postinfection. The blastogenic activity of lymphocytes was shaped by their interaction with antigen presenting cells, which were present in the cell cultures during the whole culture period. Moreover, the balance between cytokines derived from adherent leukocytes including interleukin 8 - IL-8 as well as interferon gamma - IFN-γ, and transforming growth factor beta - TGF-β delivered by lymphocytes, was probably important for the successful proliferation of lymphocytes. The H. pylori specific lymphocytes were not propagated in peripheral blood and spleen of H. pylori infected animals. The modulation of immunocompetent cells by H. pylori antigens or their different distribution cannot be excluded.
Źródło:: Acta Biochimica Polonica; 2014, 61, 2; 295-303
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Multidirectional effects of triterpene saponins on cancer cells - mini-review of in vitro studies
Autorzy:: Koczurkiewicz, Paulina
Czyż, Jarosław
Podolak, Irma
Wójcik, Katarzyna
Galanty, Agnieszka
Janeczko, Zbigniew
Michalik, Marta
Powiązania:: https://bibliotekanauki.pl/articles/1038965.pdf
Data publikacji:: 2015
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: triterpene saponins
cancer cells
invasiveness
apoptosis
proliferation
Opis:: Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective, gastroprotective and antimicrobial properties. Recently, a potential anticancer activity of saponins has been suggested by their cytotoxic, cytostatic, pro-apoptotic and anti-invasive effects. At high concentrations (more than 100 µM) saponins exert cytotoxic and haemolytic effects via permeabilization of the cell membranes. Noteworthy, the inhibition of cancer cell proliferation, the induction of apoptosis and attenuation of cell invasiveness is observed in the presence of low saponin concentrations. Saponins might affect the expression of genes associated with malignancy. These alterations are directly related to the invasive phenotype of cancer cells and depend on "cellular context". It illustrates the relationships between the action of saponins, and the momentary genomic/proteomic status of cancer cells. Here, we discuss the hallmarks of anti-cancer activity of saponins with the particular emphasis on anti-invasive effect of diverse groups of saponins that have been investigated in relation to tumor therapy.
Źródło:: Acta Biochimica Polonica; 2015, 62, 3; 383-393
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Artificial extracellular matrices of collagen fibrils and lactoferrin as coatings to enhance osteoblast behavior
Autorzy:: Vandorovcova, M.
Bacakova, L.
Dubruel, P.
Douglas, T. E. L.
Powiązania:: https://bibliotekanauki.pl/articles/284321.pdf
Data publikacji:: 2012
Wydawca:: Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:: coating
collagen
osteoblasts
proliferation
extracellular matrix
lactoferrin
Opis:: Lactoferrin, a glycoprotein found in milk, has stimulated osteoblast proliferation and differentiation, but has remained relatively unexplored as a biomaterial component. In this study, artificial extracellular matrices consisting of fibrils of collagen type I containing lactoferrin were used as coatings for the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA). The numbers of cells, their viability and proliferation rate were evaluated in various time intervals. Additionally, cell initial spreading area on day 1 was measured. The results show that lactoferrin accelerates fibril-logenesis, leads to increased osteoblast cell numbers 1 and 3 days post-seeding, and encourages their proliferation in each of the tested time intervals.
Źródło:: Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 132-134
1429-7248
Pojawia się w:: Engineering of Biomaterials
Dostawca treści:: Biblioteka Nauki

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