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    Wyświetlanie 1-9 z 9
    Tytuł:
    Synergism of antiproliferative effects of young green barley and chlorella water extracts against human breast cancer cells
    Autorzy:
    Lemieszek, M.K.
    Rzeski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/28761695.pdf
    Data publikacji:
    2023
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2023, 30, 2; 273-280
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Impact of phytochemicals and plant extracts on viability and proliferation of NK cell line NK-92 – a closer look at immunomodulatory properties of goji berries extract in human colon cancer cells
    Autorzy:
    Kwaśnik, P.
    Lemieszek, M.K.
    Rzeski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/28762796.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2021, 28, 2; 291-299
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Enhancement of chemopreventive properties of young green barley and chlorella extracts used together against colon cancer cells
    Autorzy:
    Lemieszek, M.K.
    Rzeski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/28762889.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 4; 591-598
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Chemopreventive properties of young green barley extracts in in vitro model of colon cancer
    Autorzy:
    Kawka, K.
    Lemieszek, M.K.
    Rzeski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/2082991.pdf
    Data publikacji:
    2019
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Hordeum vulgare
    barley
    colon cancer
    chemoprevention
    Opis:
    Introduction and objective. Young green barley is the most valuable source of nutrients and bioactive substances. It has a broad spectrum of health-promoting properties such as antioxidant, anti-inflammatory, hypoglycaemic, anti-depressant, anti-atherosclerotic and anticancer. The presented study is an attempt to extend this knowledge with particular emphasis on the possibility of using green barley in colon cancer prevention. Materials and method. Extracts were prepared on the basis of two commercial products: ground dried barley grass (YGB INT) and powder of young green barley juice (YGB GW). Their influence on colon epithelial cells (CCD841 CoN) viability and proliferation were analyzed by LDH and MTT assays. Anticancer properties of extracts were screened on colon cancer cell lines (LS180, HT-29) by MTT and BrdU assays. Changes in cells morphology induced by extracts were investigated after May-Grünwald-Giemsa staining. Results. Tested extracts were not toxic against CCD841 CoN and did not affected their proliferation or morphology (LDH test, MTT test, microscopy observation). The MTT revealed that extracts significantly inhibited proliferation of colon cancer cells in a dose-dependent manner. Results of BrdU test confirmed antiproliferative properties of extracts, but opposite to MTT test, indicated YGB GW as a better anticancer agent. Light microscopy observation proved the data obtained from both MTT and BrdU tests and additionally suggested the ability of the extracts to induce necrosis in LS180 and HT-29 cells. Conclusions. The study demonstrated that YGB extracts specifically inhibit proliferation of colon cancer cells without any undesirable effect on colon epithelial cells. Obtained results will provide a rationele for the future development of dietary supplements which could be beneficial in colon cancer chemoprevention.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 174-181
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Anti-epileptic drugs inhibit viability of synoviocytes in vitro
    Autorzy:
    Parada-Turska, J.
    Nowicka-Stazka, P.
    Majdan, M.
    Jablonski, M.
    Turski, W.A.
    Rzeski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/51168.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    Introduction and objective: The hyperplasia of synovial fibroblasts is considered to be essential for the evolution of joint destruction in rheumatoid arthritis (RA). Previously, we reported that anti-rheumatic drugs, both COX inhibitors and disease-modifying anti-rheumatic drugs inhibit proliferation of synoviocytes in vitro. The presented study investigates the effect of anti-epileptic drugs on the viability and proliferation of synovial fibroblasts in vitro. Methods: Experiments were conducted on human synoviocytes derived from an RA patient and rabbit synoviocytes cell line HIG-82. Cell proliferation and viability were assessed by means of BrdU assay and MTT assay, respectively. The IC50 value (the concentration of drug necessary to induce 50% inhibition) together with confidence limits was calculated. Results: Carbamazepine inhibited proliferation of human fibroblasts and viability of HIG-82 with IC50 values of 86 μM and 82 μM, respectively. Diphenylhydantoin, valproate and phenobarbital inhibited viability of HIG-82 cells with the IC50 values of 110, 500 and 1031 μM, respectively. Conclusion: Based on these findings, it can be suggested that anti-epileptic drugs may have a disease-modifying effect on rheumatoid synovial proliferation.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2013, 20, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytoprotective effect of silybin against lasalocid-induced toxicity in HepG2 cells
    Autorzy:
    Radko, L.
    Cybulski, W.
    Rzeski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/31464.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Opis:
    Lasalocid is an ionophore coccidiostatic agent frequently used in poultry. Its extensive use causes the formation of residues in edible tissues and eggs which may pose a risk to consumers. Silybin is the main compound extracted from the herb milk thistle Silybum marianum and its hepatoprotective effect has been reported in literature. The aim of the study was to compare lasalocid and silybin cytotoxic effects followed by their combined use in HepG2 cell line. A cytoprotective effect resulting from the interaction of both pharmacologically active substances was measured. In this study, an MTT test, coomassie brillant blue binding test, and LDH release test determined the effective concentration (EC₅₀) of the compounds. The isobolograms and combination index were used to assess the nature of interaction. The lowest EC₅₀-value for lasalocid was established via the MTT test. This study revealed a lack of silybin cytotoxic effect on the cells. Co-actions of the two drugs led to a significant decrease of lasalocid cytotoxicity. The isobolograms and combination index showed a remarkable antagonistic effect in the course of silybin and lasalocid interaction. The results indicate that silybin revealed a cytoprotective effect when incubated with lasalocid since its cytotoxic impact on HepG2 cells has been significantly diminished.
    Źródło:
    Polish Journal of Veterinary Sciences; 2013, 16, 2
    1505-1773
    Pojawia się w:
    Polish Journal of Veterinary Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Neuroprotective activity of 2-amino-1,3,4-thiadiazole derivative 4BrABT – an in vitro study
    Autorzy:
    Juszczak, M.
    Walczak, K.
    Langner, E.
    Karpinska, M.
    Matysiak, J.
    Rzeski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/49999.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Medycyny Wsi
    Opis:
    4BrABT (2-(4-Bromophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole) is a compound known for its interesting in vitro anticancer profile. 4BrABT inhibited proliferation and motility of several cancer cell lines in concentrations which were not toxic to normal cells. A major problem associated with cancer chemotherapy, but also caused by environmental factors such as pesticides, is neurotoxicity. Therefore, the aim of the presented study was an in vitro evaluation of the neuroprotective activity of this compound. 4BrABT activity (1–100 μM) was tested in cultures of mouse neurons, rat astrocytes and rat oligodendrocytes. A possible protective action of the compound in different neurodegenerative models, as serum deprivation (SD), excitotoxicity (presence of 500 μM glutamate in culture medium), as well as cisplatin toxicity (astroglia – 50 μM and oligodendroglia – 100 μM) was investigated. Cell viability in the tested cultures was assessed with the use of LDH and MTT methods. Moreover, 4BrABT ability to prevent the cisplatin-induced apoptosis in astrocyte and oligodendrocyte cultures was analysed after Hoechst 33342 fluorostaining. The obtained results indicate that 4BrABT was not toxic to neurons, astrocytes and oligodendrocytes. Moreover, a decrease in the neuronal LDH level was observed, which may suggest the ability of 4BrABT to act as a trophic agent. Furthermore, the protective action of the studied compound was shown in neuronal cultures exposed to neurotoxic conditions (presence of glutamate and trophic stress) and in cisplatin-treated astrocytes and oligodendrocytes. The expression of anticancer and neuroprotective activity raises hopes for the potential use of 4BrABT as a safe anticancer drug, or neuroprotective agent in chemotherapy-associated neurotoxicity.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2013, 20, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Tumour cell growth-inhibiting properties of water extract isolated from heated potato fi bre (Potex)
    Autorzy:
    Langner, E.
    Rzeski, W.
    Kaczor, J.
    Kandefer-Szerszen, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/3113.pdf
    Data publikacji:
    2009
    Wydawca:
    Instytut Medycyny Wsi
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2009, 03, 1
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparative analysis of different methodological approaches to the in vitro study of tumour cells chemosensitivity
    Autorzy:
    Paduch, R
    Slotwinska, M.
    Stachura, A.
    Rzeski, W.
    Zdzisinska, B.
    Kandefer-Szerszen, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/961243.pdf
    Data publikacji:
    2001
    Wydawca:
    Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
    Tematy:
    chemosensitivity
    etoposide
    tumour cell
    drug sensitivity
    cisplatin
    gelatin sponge
    growth
    in vitro
    Opis:
    Drug sensitivity assay was performed using two human tumour celi lines: HeLa and Hep-2 cultivated in two-dimensional monolayer celi cultures and three-dimensional cultures on gelatine sponge SpongostanK. Two cytostatics with different mechanisms of anti-tumour action were used: cisplatin and etoposide. Chemosensitivity of tumour cells was assessed by counting the number of viable and nonviable cells (cytostatic and cytotoxic activity of drugs), by counting the number of apoptotic cells and by clonogenic assay of viable cells. We found that the clonogenic assay was morę sensitive than the other tests used, especially after long-term (7 days) treatment of tumour cells with cytostatics. A short (24h) treatment with cytostatics gave false results which were not confirmed after prolonged treatment with cytostatics. We suppose that short treatment tests should not be used for examination of the chemosensitivity of tumour cells isolated from patients. Tumour cells growing on SpongostanH were viable for a longer time than in monolayer cultures and exhibited chemosensitivity comparable to monolayer celi cultures despite of their multilayer growth on gelatine sponge.
    Do badań wrażliwości na cytostatyki użyto dwie ludzkie linie nowotworowe: HeLa i Hep-2, hodowane w formie murawy dwuwymiarowej (płaskiej) oraz w formie przestrzennej, trójwymiarowej, na gąbce żelatynowej Spongostan". W badaniach użyto cytostatyki posiadające różny mechanizm działania przeciwnowotworowego, a mianowicie cisplatynę i etopozyd. Wrażliwość komórek nowotworowych na chemioterapeutyki określano ilością komórek przeżywających i martwych (cytostatyczne i cytotoksyczne właściwości leków), ilością komórek apoptotycznych oraz oceniano klonogenne właściwości komórek przeżywających. Stwierdzono, że ocena klonogennych właściwości komórek jest metodą bardziej czułą w porównaniu z innymi testami, szczególnie po długim (7-dniowym) kontakcie komórek z cytostatykami. Ocena krótkotrwałego (24-godz.) kontaktu komórek nowotworowych z cytostatykami dawała fałszywe wyniki, nie potwierdzone po długotrwałej inkubacji komórek z cytostatykami. Uważamy, że testy polegające na ocenie efektu krótkotrwałej inkubacji komórek z lekami nie powinny być stosowane do oceny wrażliwości na chemioterapeutyki komórek nowotworowych izolowanych od pacjenta. Komórki nowotworowe rosnące na Spongostanie” były żywe dłużej niż rosnące w hodowlach płaskich i pomimo wielowarstwowego wzrostu na gąbce żelatynowej wykazywały wrażliwość na leki porównywalną z hodowlami płaskimi.
    Źródło:
    Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia; 2001, 56
    2083-3563
    0066-2232
    Pojawia się w:
    Annales Universitatis Mariae Curie-Sklodowska, sectio C – Biologia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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