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Tytuł:
Properties of mitochondrial DNA polymerase in mitochondrial DNA synthesis in yeast
Autorzy:
Biswas, Tapan
Sengupta, Pritam
Green, Renee
Hakim, Paul
Biswas, Bani
Sen, Sribir
Powiązania:
https://bibliotekanauki.pl/articles/1045221.pdf
Data publikacji:
1995
Wydawca:
Polskie Towarzystwo Biochemiczne
Źródło:
Acta Biochimica Polonica; 1995, 42, 3; 317-324
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Organisation of Unionid mitochondrial DNA
Autorzy:
Soroka, M.
Powiązania:
https://bibliotekanauki.pl/articles/83417.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Mikołaja Kopernika. Wydział Biologii i Ochrony Środowiska. Stowarzyszenie Malakologów Polskich
Źródło:
Folia Malacologica; 2010, 18, 3
1506-7629
Pojawia się w:
Folia Malacologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mitochondrial DNA in pediatric leukemia patients
Autorzy:
Kodroń, Agata
Ghanim, Magda
Krawczyk, Katarzyna
Stelmaszczyk-Emmel, Anna
Tońska, Katarzyna
Demkow, Urszula
Bartnik, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1038705.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
pediatric ALL
mtDNA
chemotherapy
Opis:
Numerous studies of mitochondrial DNA (mtDNA) in cancer have shown differences between mtDNA sequences in tumor and normal tissue and at various stages of cancer treatment in the same patient. However, there is little data on acute lymphoblastic leukemia (ALL), the most common type of leukemia in children. In this study we compared mitochondrial sequence variation in the D-loop region and in 5 genes of mtDNA in bone marrow samples of 6 pediatric patients with ALL at various stages of therapy. We found several common polymorphisms and one variant at position 3688 whose level varied during leukemia treatment. Our results suggest that mitochondrial DNA mutations, whose levels change during patient treatment, could be potential biomarkers for monitoring treatment efficacy and disease progression.
Źródło:
Acta Biochimica Polonica; 2017, 64, 1; 183-187
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Organisation of mitochondrial DNA in dreissenid bivalves
Autorzy:
Soroka, M.
Burzynski, A.
Rymaszewska, A.
Powiązania:
https://bibliotekanauki.pl/articles/84655.pdf
Data publikacji:
2012
Wydawca:
Uniwersytet Mikołaja Kopernika. Wydział Biologii i Ochrony Środowiska. Stowarzyszenie Malakologów Polskich
Tematy:
mitochondrial DNA
bivalve
Dreissenidae
genome
Cristaria plicata
Placopecten magellanicus
gene number
Dreissena
Dreissena polymorpha
Dreissena bugensis
Źródło:
Folia Malacologica; 2012, 20, 1
1506-7629
Pojawia się w:
Folia Malacologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fluorescent in situ hybridization of mitochondrial DNA and RNA
Autorzy:
Alán, Lukáš
Zelenka, Jaroslav
Ježek, Jan
Dlasková, Andrea
Ježek, Petr
Powiązania:
https://bibliotekanauki.pl/articles/1040297.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
molecular beacon fluorescent hybridization probes
nucleoids of mitochondrial DNA
confocal microscopy
transcription and replication intermediates
mitochondrial DNA and RNA
Opis:
To reveal nucleic acid localization in mitochondria, we designed molecular beacon fluorescent probes against: i) the light strand complementary to ND5 mitochondrial DNA (mtDNA) gene (annealing also to corresponding mRNA); ii) displacement (D) loop 7S DNA (annealing also to parallel heavy strand mtDNA and corresponding light strand transcript); iii) the proximal D-loop heavy strand displaced by the light strand promoter minor RNA. Confocal microscopy demonstrated ND5 probe spreading (less for other probes) in mitochondrial reticulum tubules but upon RNase A treatment all probes contoured mtDNA nucleoid localization. DNase I spread the signal over mitochondrial tubules. Future applications are discussed.
Źródło:
Acta Biochimica Polonica; 2010, 57, 4; 403-408
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mitochondrial DNA-based diagnostic molecular markers for freshwater bivalves
Autorzy:
Soroka, M.
Grygienczo-Razniewska, E.
Powiązania:
https://bibliotekanauki.pl/articles/84024.pdf
Data publikacji:
2005
Wydawca:
Uniwersytet Mikołaja Kopernika. Wydział Biologii i Ochrony Środowiska. Stowarzyszenie Malakologów Polskich
Opis:
The study was carried out on 9 species of freshwater bivalves (Dreissena polymorpha, D. bugensis, Unio crassus, U. pictorum, U. tumidus, Anodonta anatina, A. cygnea, A. woodiana, and Pseudanodonta complanata). The mitochondrial COI gene studied with PCR-RFLP and 6 restriction enzymes (ScrFI, Csp6I, BsiZI, EcoRI, BamHI and AluI) showed the absence of individual variability within each species studied. The genetic variability of the COI involved differences at the species, genus, and family level, depending on the restriction enzyme used. Four restriction enzymes (ScrFI, Csp6I, BsiZI and AluI) proved efficient in differentiating between D. polymorpha and D. bugensis as well as in identifying the three Unio species (Csp6I and AluI), U. crassus, and P. complanata (ScrFI and AluI). EcoRI and AluI made it possible to identify A. anatina and P. complanata. Two (for EcoRI), 3 (for Csp6I, BsiZI), 5 (for ScrFI) and 9 (for AluI) unique genotypes that occurred in a single species each were observed; the enzymes may therefore be regarded as species-specific markers. Only restriction enzyme AluI can differentiate between A. cygnea and A. woodiana.
Źródło:
Folia Malacologica; 2005, 13, 4
1506-7629
Pojawia się w:
Folia Malacologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mitochondrial DNA sequence in phylogenetic studies on lymnaeid snails
Autorzy:
Rybska, E.
Pacak, A.
Szwykowska-Kulinska, Z.
Lesicki, A.
Powiązania:
https://bibliotekanauki.pl/articles/84362.pdf
Data publikacji:
2002
Wydawca:
Uniwersytet Mikołaja Kopernika. Wydział Biologii i Ochrony Środowiska. Stowarzyszenie Malakologów Polskich
Źródło:
Folia Malacologica; 2002, 10, 1
1506-7629
Pojawia się w:
Folia Malacologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characteristics of mitochondrial DNA of unionid bivalves (Mollusca: Bivalvia: Unionidae). I. Detection and characteristics of doubly uniparental inheritance (DUI) of unionid mitochondrial DNA
Autorzy:
Soroka, M.
Powiązania:
https://bibliotekanauki.pl/articles/84282.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Mikołaja Kopernika. Wydział Biologii i Ochrony Środowiska. Stowarzyszenie Malakologów Polskich
Opis:
Doubly Uniparental Inheritance (DUI), a peculiar way of inheritance of mitochondrial DNA in animals, has been detected in seven families of marine and freshwater bivalves, including Unionidae. DUI involves two independently inherited mitochondrial genomes: maternal (F genome) and paternal (M genome), which show different tissue localisation and wide genetic variation. F genomes occur in somatic tissues of both sexes and are inherited maternally (Strict Maternal Inheritance, SMI). M genomes are located in male germ cells and transmitted to next generations along the male lineage, i.e. from fathers to male offspring. The objective of this study was detection of M genomes and characteristics of DUI in unionid bivalves from Poland, based on sequential analyses of seven mitochondrial genes. This is the study to analyse F and M haplotypes at intra- and interspecific level in seven species of freshwater mussels. DUI was first observed in species of the genus Unio (U. crassus, U. pictorum and U. tumidus), and the best M haplotype marker was gene cox1. In the studiem bivalves F and M sequences showed a similar intraspecific variation, with differences among the genes. Three tRNA genes showed the smallest (ca. 20%) nucleotide variation, followed by the gene coding for RNA for the small ribosomal subunit, srRNA (24%); a significantly greater variation (exceeding 30%) was recorded for protein-coding genes (cox1, cytb) and the gene coding for RNA for the large ribosomal subunit, lrRNA. Interspecific variation of F sequences of the studied unionids ranged from 5% for tRNAs to18% for cytb. Higher values were observed for M sequences: from 7% for tRNAs to19% for cox1. The Chinese mussel occurring in Poland, despite the morphology-based identification as Anodonta / Sinanodonta woodiana, proved to be genetically more similar to A. arcaeformis than toAsian specimens of A. woodiana. Phylogenetic analyses showed that in the genus Unio the youngest species were U. pictorum and U. mancus, and the earliest species was U. tumidus showing the greatest genetic distinctness.
Źródło:
Folia Malacologica; 2010, 18, 4
1506-7629
Pojawia się w:
Folia Malacologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mitochondrial DNA variability in Gyimesi Racka and Turcana sheep breeds
Autorzy:
Kusza, Szilvia
Zakar, Erika
Budai, Csilla
Cziszter, Ludovic-Toma
Padeanu, Ioan
Gavojdian, Dinu
Powiązania:
https://bibliotekanauki.pl/articles/1039104.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
farm animal conservation
genetic diversity
mtDNA
trans-boundary breeds
Zackel group
Opis:
The current knowledge and documentation on the origins and relationship between Gyimesi Racka reared in Hungary and the Romanian Turcana is rather controversial. Lack of information and scientific reliable proofs for the divergent theories found in the two countries motivated us to implement a trial using molecular methods to assess the genetic distance and diversity in the two breeds. Hair follicles were collected from Gyimesi Racka (2 phenotypes) and from Turcana (6 ecotypes). The 599 bp segment of the D-loop region of the mitochondrial DNA was sequenced. Altogether, 42 haplotypes were identified, while 23 were found in both populations. Populations were highly diverse according to the haplotype and nucleotide diversity indices. AMOVA analysis showed that most of the variation was observed within populations (98%), indicating a weak genetic structure between the two breeds. Animals were grouped into seven groups based on their phenotype; however genetic distances among them were also low. Tajima's D, Fu's Fs, goodness-of-fit statistics, mismatch distribution and network analysis suggested recent demographic expansion. Current comprehensive mtDNA study indicates that there is very low level of genetic differentiation between the Gyimesi Racka and Turcana populations therefore they are de facto one trans-boundary breed.
Źródło:
Acta Biochimica Polonica; 2015, 62, 2; 273-280
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of ancient mitochondrial DNA of the Baltic Sea sturgeon (Acipenser sp.)
Autorzy:
Fopp-Bayat, D.
Ciesielski, S.
Luczyński, M.
Powiązania:
https://bibliotekanauki.pl/articles/363174.pdf
Data publikacji:
2005
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:
jesiotr
historyczny mtDNA
filogeneza molekularna
gen cytochromu b
Morze Bałtyckie
Acipenser baeri
Acipenser oxyrinchus
Acipenser sturio
ancient mtDNA
cytochrome b gene
molecular phylogeny
Opis:
Genetic relatedness between Baltic Sea sturgeon (Acipenser sturio L.) specimens caught in different geographic areas is not clear. According to previous studies, fish captured in different locations within the historic area of A. sturio habitation are genetically different to each other. We have examined a fragment (191 base pairs) of mitochondrial cytochrome b gene of four specimens of A. sturio found in Poland: three fish were preserved in museums of natural history and the bone of one fish was from an archaeological site. DNA sequences of the three museum samples were identical, whereas the DNA sequence of the archaeological sample differed in the 918 position of the cytochrome b gene. All the analyzed DNA fragments were similar to those of Acipenser baeri and genetically distant to Acipenser sturio and A. oxyrinchus.
Źródło:
Environmental Biotechnology; 2005, 1, 1; 29-33
1734-4964
Pojawia się w:
Environmental Biotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
RNA-seq reveals differentially expressed genes in cucumber MSC lines possessing mitochondrial DNA rearrangements
Autorzy:
Mroz, T.
Pryszcz, L.
Skarzynska, A.
Kielkowska, A.
Havey, M.
Bartoszewski, G.
Powiązania:
https://bibliotekanauki.pl/articles/80502.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
cucumber
gene expression
mitochondrial DNA
transcriptome
wild-type line
oxidoreductase
rearrangement
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nuclear and mitochondrial genome responses in HeLa cells treated with inhibitors of mitochondrial DNA expression
Autorzy:
Piechota, Janusz
Szczęsny, Roman
Wolanin, Kamila
Chlebowski, Aleksander
Bartnik, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1041204.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
thiamphenicol
mtDNA depletion
HeLa
dideoxycytidine
mitochondrial biogenesis
ethidium bromide
Opis:
The influence of mutations in the mitochondrial DNA (mtDNA) on the bioenergetic metabolism of the cell is still poorly understood. Many of the mutations in the mtDNA affect the expression of the mitochondrial genome. Investigations on cells from patients are not easy, especially as the mitochondrial DNA is heteroplasmic and this state is changed in culture. Moreover, the nuclear background and the mitochondrial haplotype may affect the behaviour of cells. Transfer of patient mitochondria to rho zero cell lines is also not optimal as these cells in general have many nuclear changes which may also affect cell behaviour. Thus, we decided to use inhibitors of mitochondrial genome expression, such as thiamphenicol, ethidium bromide and dideoxycytidine to investigate the bioenergetic metabolism of HeLa cells. We found that oxidative phosphorylation and glycolysis participate equally in ATP production in HeLa cells and that decreased activity of the respiratory chain leads to increased glycolysis and the reduction of cell growth. Insufficient ATP production in the oxidative phosphorylation process was not compensated by increased proliferation of the mitochondria. However, we were able to show that there are some mechanisms compensating limited expression of the mitochondrial genome within the mitochondria. Experiments with dideoxycytidine revealed that 10-fold decrease of the mtDNA copy number resulted in almost normal activity of cytochrome c oxidase. We found that mtDNA depletion is compensated mostly on the level of RNA metabolism in the mitochondria. Thus, our results are in agreement with the hypothesis that transcription initiation rather than mtDNA copy number is a rate limiting factor for expression of the mitochondrial genome.
Źródło:
Acta Biochimica Polonica; 2006, 53, 3; 485-495
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the suitability of mitochondrial DNA for species identification of microtraces and forensic traces
Autorzy:
Natonek-Wiśniewska, Małgorzata
Krzyścin, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1038564.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
biological traces
forensic DNA analysis
species identification of forensic DNA
species identification of biological traces
mtDNA
Opis:
The objective of the study was to demonstrate how mitochondrial DNA (mtDNA) can be used to determine the species origin of animal microtraces. The study included pieces of cat and dog hair without the root, a fragment of cooked chicken bone (0.1g), three goose down samples (0.028 g), a pork swab, a pork scratching (5×5×5 mm), and pork lard (0.22 g). DNA was isolated from all of these samples using the method appropriate for the particular source material. The extracts had DNA concentration exceeding 5.4 ng/µl with A260/280 purity range of 1.14-1.88. Next, the samples were subjected to PCR and real-time PCR with species-specific primers and primers complementary to mitochondrial DNA (mtDNA). Control reactions based on the amplification of eukaryotic-specific fragment (18S rRNA) were additionally performed. PCR and real-time PCR products for detection of species-specific mtDNA were obtained for all templates, whereas during the detection of eukaryote DNA no product was obtained for dog and cat hair only. The poor quality of the obtained DNA did not prevent the analysis. The results showed that mitochondrial DNA is suitable for identification of small or highly processed samples, in which genomic DNA often cannot be analyzed.
Źródło:
Acta Biochimica Polonica; 2017, 64, 4; 705-708
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biotechnology in the restoration of extinct animal species. An analysis of genomic and mitochondrial DNA of aurochs
Autorzy:
Lipinski, D.
Przystalowska, H.
Szalata, M.
Zeyland, J.
Wielgus, K.
Frackowiak, H.
Dzieduszycki, A.M.
Ryba, M.S.
Slomski, R.
Powiązania:
https://bibliotekanauki.pl/articles/80741.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
analysis
animal species
aurochs
biotechnology
description
extinct species
genomic DNA
history
mitochondrial DNA
museum
restoration
skeleton
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Variation patterns of mitochondrial DNA of Abies alba Mill. in suture zones of postglacial migration in Europe
Autorzy:
Gomory, D
Longauer, R.
Liepelt, S.
Ballian, D.
Brus, R.
Kraigher, H.
Parpan, V.I.
Parpan, T.V.
Paule, L.
Stupar, V.I.
Ziegenhagen, B.
Powiązania:
https://bibliotekanauki.pl/articles/58447.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
postglacial migration
mitochondrial DNA
Abies alba
suture zone
silver fir
Europe
Opis:
Thirty silver fir populations originating from the putative suture zones of the postglacial recolonization (Slovenia, Bosnia and Hercegovina, Ukraine) were studied using a mitochondrial nad5-4 gene marker. The geographical distribution of mtDNA haplotypes in the Ukrainian Carpathians and their northern foothills indicates a very recent meeting of migration streams arriving from the Romanian Carpathians and Central Europe. In the western part of the Balkan Peninsula, two counterparallel migration streams are the most plausible explanation of the pattern observed. The haplotype typical for the Balkan Peninsula predominates along the Adrian coast, whereas the CentralEuropean haplotype is more represented in the inland.
Źródło:
Acta Societatis Botanicorum Poloniae; 2004, 73, 3
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detection of recombinant mitochondrial genomes: Implications for the mechanism of mtDNA inheritance in mussel Mytilus
Autorzy:
Filipowicz, M.
Burzyński, A.
Wenne, R.
Powiązania:
https://bibliotekanauki.pl/articles/363232.pdf
Data publikacji:
2008
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie
Tematy:
DNA mitochondrialne
rekombinacja
Mytilus
mitochondrial DNA
recombination
Opis:
Recombination plays a fundamental role in the creation of biodiversity. It is the mechanism inducing formation of rearrangements within the genomes which, beside mutations, are the major source of genetic variation. In the process of recombination a single or double DNA strand is broken and rejoined with unassociated DNA fragments. There are several types of recombination: homologous recombination, sitespecific recombination and transposition. Within mitochondrial genomes, inter- and intra-molecular recombination can occur. Except for intramolecular recombination of mtDNA, the other types of recombination always result in the creation of mosaic genomes. However, in the natural populations mtDNA recombination is detected extremely rarely. It is caused by the clonal inheritance of mitochondrial genomes and consequential lack of sufficient divergence between parental mitochondrial molecules. Mussels of the genus Mytilus possess two types of mitochondrial genomes inherited from males and females, respectively, and their mode of mtDNA inheritance is called doubly uniparental inheritance (DUI). The presence of two highly diverged parental molecules gives the opportunity for detection of recombinant variants. This feature of Mytilus mtDNA can be broadly exploited in the search for and characteristics of recombinant sequences. Apart from the high level of sequence divergence, fusion of mitochondria and appropriate enzymatic toolkit are principal requirements for the occurrence of recombination. The majority of phylogenetic and demographic analysis based on mtDNA assumes the lack of recombination. If this assumption turned out to be erroneous, previous analyses would be weakened. Recombination is associated with DUI abnormalities, e.g. masculinization of mitochondrial genomes. It may even lead to the breakdown of DUI system resulting in the new, unidentified mode of mtDNA inheritance in mussel Mytilus that might be regulated by stochastic events.
Źródło:
Environmental Biotechnology; 2008, 4, 2; 54-59
1734-4964
Pojawia się w:
Environmental Biotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Human lipoprotein lipase deficiency: does chronic dyslipidemia lead to increased oxidative stress and mitochondrial DNA damage in blood cells?
Autorzy:
Ven Murthy, M.
Julien, Pierre
Singh, Preman
Levy, Emile
Powiązania:
https://bibliotekanauki.pl/articles/1045189.pdf
Data publikacji:
1996
Wydawca:
Polskie Towarzystwo Biochemiczne
Źródło:
Acta Biochimica Polonica; 1996, 43, 1; 227-240
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Searching for association of the CAG repeat polymorphism in the mitochondrial DNA polymerase gamma gene (POLG) with colorectal cancer
Autorzy:
Linkowska, Katarzyna
Jawień, Arkadiusz
Marszałek, Andrzej
Skonieczna, Katarzyna
Grzybowski, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1039019.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
POLG gene
CAG repeat
colorectal cancer
somatic mutations
Opis:
Mitochondrial DNA polymerase gamma (POLG) is the only DNA polymerase involved in maintaining the mitochondrial genome. Recent studies demonstrated an association of CAG repeat polymorphism in the second exon of POLG gene with the risk of cancer. We investigated the CAG repeat variability in the POLG gene in tumor and non-tumor tissues from colorectal cancer patients and in DNA samples isolated from blood obtained from age-matched healthy persons. Somatically occuring CAG-repeat alterations in cancer tissues have been observed in 10% of patients, but no association has been found between the CAG repeat variants in the POLG gene and colorectal cancer risk.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 625-627
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in accumulation of heteroplasmic mitochondrial DNA and frequency of recombination via short repeats during plant lifetime in Phaseolus vulgaris
Autorzy:
Woloszynska, Magdalena
Gola, Edyta
Piechota, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1039695.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Phaseolus vulgaris
sublimons
heteroplasmy
quantitative real-time PCR
plant mitochondrial genome
mtDNA recombination
Opis:
Recombination via short repeats in plant mitochondrial genomes results in sublimons - DNA molecules with a copy number much lower compared to the main mitochondrial genome. Coexistence of stoichiometrically different mitotypes, called heteroplasmy, plays an important evolutionary role, since sublimons occasionally replace the main genome resulting in a new plant phenotype. It is not clear, how frequency of recombination and sublimon production is regulated and how it is related to changes in the quantity of the main genome and sublimons. We analyzed the accumulation of two recombining main genome sequences and two resulting sublimons in apical meristems, undifferentiated tissues and leaves of different age of Phaseolus vulgaris. Copy numbers of the main genome sequences varied greatly depending on tissue type and organ age while accumulation of sublimons remained much more stable. Although the overall accumulation of plant mtDNA decreased with the leaf age, the quantity of sublimons increased relative to the main genome indicating a higher frequency of recombination via the short 314 bp repeat. Recombination was symmetrical in young developing leaves while in senescent tissues it shifted towards asymmetric events resulting in overrepresentation of one product. We propose that during plant lifetime replication and recombination frequencies change oppositely sustaining heteroplasmic compositions of the genome, which are favorable for inheritance and maintenance of complex plant mtDNA.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 703-709
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mitochondrial DNA transmission in the hybridization and introgression zone of Mytilus edulis and M.Trossulus in the Baltic and Danish straits
Autorzy:
Kijewski, T.
Wenne, R.
Powiązania:
https://bibliotekanauki.pl/articles/83498.pdf
Data publikacji:
2000
Wydawca:
Uniwersytet Mikołaja Kopernika. Wydział Biologii i Ochrony Środowiska. Stowarzyszenie Malakologów Polskich
Źródło:
Folia Malacologica; 2000, 08, 4
1506-7629
Pojawia się w:
Folia Malacologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Heteroplasmy analysis in the Polish patients with 11778A mutation responsible for Leber hereditary optic neuropathy.
Autorzy:
Mroczek-Tońska, Katarzyna
Ratajska, Dorota
Guillot, Cecile
Sąsiek, Maria
Ambroziak, Anna
Lubos, Leszek
Bartnik, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1043837.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
11778A mutation
mitochondrial DNA
human
Leber hereditary optic neuropathy
Opis:
We have analysed the heteroplasmy level in 11 individuals from 3 families harbouring the mitochondrial 11778A mutation responsible for Leber hereditary optic neuropathy using last cycle hot PCR. The mutation level exceeded 90% both in affected and in unaffected individuals. We also checked whether any of the families belonged to the J haplogroup of mitochondrial DNA and obtained a negative result.
Źródło:
Acta Biochimica Polonica; 2002, 49, 1; 257-262
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
W poszukiwaniu Piastów
In search of the Piasts
Autorzy:
Handschuh, Luiza
Stolarek, Ireneusz
Juras, Anna
Zeńczak, Michał
Marcinkowska-Swojak, Małgorzata
Myszka, Anna
Trzciński, Dawid
Losik-Sidorska, Aleksandra
Wojtczak, Jakub
Philips, Anna
Różański, Artur
Dębski, Artur
Kozłowski, Piotr
Matla, Marzena
Dobosz, Józef
Jasiński, Tomasz
Piontek, Janusz
Kóčka-Krenz, Hanna
Figlerowicz, Marek
Powiązania:
https://bibliotekanauki.pl/articles/697389.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Opolski
Tematy:
The Piasts
genetic tests
DNA sequencing
ancient DNA (aDNA)
mitochondrial DNA (mt DNA)
Y chromosome
Opis:
The origin of the Piast dynasty is a matter of lively discussions and disputes. At least a few controversial hypotheses exist, but their credibility is difficult to assess due to the scarcity of written as well as material sources, especially from the time of Polish state formation. Life sciences, however, can support history and archeology. Application of genetic tests, used earlier mainly in forensic laboratories, enabled identification of the remains of King Richard III, the Romanov dynasty members and Nicolaus Copernicus. Contemporary DNA studies, based on next generation DNA sequencing, outreach the narrow area of known markers such as mitochondrial DNA (mtDNA) and selected regions of Y chromosome. Although ancient DNA (aDNA), extracted from remains, is usually highly degraded and contaminated with genetic material of microorganisms, there are methods which allow for the analysis of such material and retrieval of information about origin, kinship and some phenotypic features of an individual. Genetic studies of the Piast dynasty, a subject of our research project, have to deal with numerous difficulties. In or der to gain access to bone samples, we need to meet a number of formal requirements. Moreover, despite the existence of available abundant documentation on the Piast burials, the actual situation is not always consistent with the written sources. Our first experiences show how difficult it is to localize the remains, identify them and extract DNA of sufficient quality.
Źródło:
Opolskie Studia Administracyjno-Prawne; 2016, 14, 4 (2); 63-77
2658-1922
Pojawia się w:
Opolskie Studia Administracyjno-Prawne
Dostawca treści:
Biblioteka Nauki
Artykuł
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