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Wyświetlanie 1-15 z 19
Tytuł:
Epigenetic modulation of the activity of transgen and endogenous gene based on the example of chalcone synthase in flax
Autorzy:
Zuk, M.
Dzialo, M.
Szopa, J.
Powiązania:
https://bibliotekanauki.pl/articles/951257.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
epigenetic modulation
mutagenesis
genetic modification
chalcone synthase
flax
transgenic plant
phenylpropanoid
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, Characterization, In-Vitro Antimicrobial Evaluation and Antioxidant Studies of Some Isoxazoline Derivatives
Autorzy:
Vishnupriya, P.
Rubala mary, M.
Powiązania:
https://bibliotekanauki.pl/articles/1112444.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Chalcone
antibacterial
antifungal
antioxidant activity
isoxazole
synthesis
Opis:
The tremendous rise in development of resistance to antimicrobials has created an alarming situation for researchers and clinicians. In this regard, an attempt has been made to develop a series of azole-based derivatives. The presented study consists of the design and synthesis of some newer derivatives by incorporating the isoxazole nucleus in the pharmacophore. These are also characterized physicochemically and by spectral means (IR and microanalysis). Moreover, the antioxidant activity of these derivatives was assessed using DPPH radical scavenging methods Finally, all of the newly isolated compounds were tested for their antimicrobial activities. Herein, antimicrobial screening using the agar disc diffusion method revealed that the majority of the derivatives are most active.
Źródło:
World News of Natural Sciences; 2018, 18, 2; 72-78
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In silico screening, synthesis, in vitro evaluations antibacterial and DPPH scavenging activity of some 1,3,5-trisubstituted 2-pyrazoline derivatives as dihydrofolate reductase inhibitors
Autorzy:
Suriya, S.
Mala, V.
Powiązania:
https://bibliotekanauki.pl/articles/1112558.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Synthesis
antibacterial
antioxidant
chalcone
pyrazoline
Opis:
In this work, synthesis of three pyrazoline derivatives (6-8) is described. (E)-1,3-(phenylsubstituted)-prop-2-en-1-one (3-5) is prepared by the reaction of substituted benzaldehyde with 4-methylacetophenone, whereas condensation cyclization of the same chalcones (3-5) with phenylhydrazine hydrate in ethanol yielded 6-8. The structures of the title compounds (6-8) were characterized by chemical reactions, elemental analysis, and spectral methods such as IR spectra. The synthesized chalcone and pyrazolines were evaluated for in-vitro antibacterial and antioxidant activities against standard. The zone of inhibition for some of the newly synthesized compounds showed notable antibacterial activity against selected bacterial strains when compared with ampicillin. Significant antioxidant activities were also shown by chalcone and pyrazolines.
Źródło:
World News of Natural Sciences; 2018, 18, 2; 180-186
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and in vitro antimicrobial evaluation of some new chalcones containing vinyl ester group and substituted alkyl chain
Autorzy:
Sharma, Vinay S.
Patel, R. B.
Powiązania:
https://bibliotekanauki.pl/articles/1191249.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Antibacterial
Antifungal
Chalcone
Vinyl ester
Opis:
A novel series of chalconyl vinyl ester based derivatives were designed and synthesized. The newly synthesized compounds were studied for efficacy against several bacteria (E.Coli, P.Aeruginosa, S.Aureus, S.Pyogenus) and fungi (C.Albicans, A.Niger, Clavatus) using the broth dilution technique. Chalcones were prepared by treatment of 4-iodo acetophenone with 4-hydroxy benzaldehyde by Claisen-Schimidt condensation reaction. Various chalconyl vinyl ester derivatives (C1-C8) were prepared by reaction of chalcone with 4-n-alkoxy cinnamic acids derivatives. Compound C8 shows the best bioactive desired antibacterial analogue with less MIC value against different tested strains. All the final synthesized compounds were characterized by IR, 1H NMR, and elemental analysis.
Źródło:
World Scientific News; 2016, 54; 240-251
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and antimicrobial screening of some new pyrimido[1,2-a]benzimidazole derivatives
Autorzy:
Shah, N. M.
Joshi, H. S.
Powiązania:
https://bibliotekanauki.pl/articles/411967.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
2-aminobenzimidazole
pyrimido[1,2-a]benzimidazole
chalcone
antimicrobial activity azoloazine
Opis:
Some new pyrimido[1,2-a]benzimidazole derivatives were synthesized by reacting 2-amino benzimidazole and chalcones in n-butanol at reflux temperature. In our present study we have used various heterocyclic chalcones derived from furfural and substituted acetophenones. All synthesized compounds were characterized by IR, 1H NMR and Mass spectroscopy. All synthesized compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria which showed moderate to good activity.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 6; 56-60
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and in vitro antimicrobial evaluation of amine substituted s-triazine based thiazolidinone/chalcone hybrids
Autorzy:
Shah, D. R.
Lakum, H. P.
Chikhalia, K. H.
Powiązania:
https://bibliotekanauki.pl/articles/412622.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Antibacterial
Antifungal
Chalcone
s-Triazine
4-thiazolidinone
Opis:
In an attempt to control multidrug resistant dilemma, a library of s-triazine based on two novel series of thiazolidinone (4a-e) and chalcone (7a-e) derivatives were designed and synthesized with simple and efficient etiquette. The newly synthesized compounds were studied for efficacy against several bacteria (Staphylococcus Aureus, Bacillus Cereus, Pseudomonas Aeruginosa, Klebsiella Pneumoniae,) and fungi (Candida Albicans, Aspergillus Clavatus) using the broth dilution technique. Compound 7d was the best bioactive desired antibacterial analogue with less MIC value against different tested strains. Results of bioassay study revealed the future hope of the potent drug-candidate based on s-triazine scaffold. All the final synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR, mass and elemental analysis.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 17, 2; 207-219
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, spectral and thermal study of (2E, 6E) 2,6-bis(4-hydroxy benzylidene)-4-R-cyclohexanone
Autorzy:
Sankhavara, Dharmesh B.
Chopda, Jalpa V.
Patel, Jignesh P.
Parsania, P. H.
Powiązania:
https://bibliotekanauki.pl/articles/1070865.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Chalcone
bisphenol
heat of melting
kinetic parameters
thermal stability
Opis:
(2E,6E) 2,6-Bis(4-hydroxybenzalidene)-4-R-cyclohexanone (BHBC, R = H and MBHBC, R = CH3) was synthesized by condensing cyclohexanone/4-methylcyclohexanone with 4-hydroxy benzaldehyde using mixture of boric acid and hydrochloric acid as a catalyst at 60-70 ºC for 1 h. The structures of BHBC and MBHBC are supported by FTIR, 1HNMR, 13CNMR and MS techniques. DSC endothermic transition at 282.48 ºC (BHBC) and two endothermic transitions at 214.66 and 224.83 ºC and assigned as melting transitions. The compositions of the two isomers of MBHBC were determined from their corresponding peak areas and observed compositions are 81.5% and 18.5%, respectively for Isomer-I and Isomer-II. BHBC and MBHBC are thermally stable up to 305 ºC and 285 ºC, respectively and followed three step degradation kinetics. Both the compounds followed apparently first order degradation kinetics and were completely degraded into low molecular mass hydrocarbons.
Źródło:
World Scientific News; 2019, 123; 141-160
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterization of 1,3,5-trisubstituted pyrazoline derivatives by ultrasonic irradiation method and evaluation of its antibacterial activity
Autorzy:
Raguraman, A.
Santhi, N.
Powiązania:
https://bibliotekanauki.pl/articles/412019.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
4-methylacetophenone
ultrasonic irradiation
chalcone
2-pyrazoline
antibacterial
antifungal
Opis:
A series of novel 1,3,5-trisubstituted pyrazoline derivatives (P1-P10) have been synthesized by the reaction of substituted chalcones (C1-C10) with 4-hydroxybenzhydrazide. The starting material, chalcones were prepared by claisen Schmidt condensation of 4-methylacetophenone with substituted aldehydes in the presence of sodium hydroxide in ethanol. 4-hydroxybenzhydrazide was synthesized by condensing methyl 4-hydroxybenzoate with hydrazine hydrate. The cycloaddition of chalcones with 4-hydroxybenzhydrazide gives 1, 3, 5-trisubstituted pyrazoline derivatives. The structures of synthesized derivatives were confirmed by IR, 1HNMR and 13C NMR spectrum. The synthesized compounds were screened for their antibacterial and antifungal activity.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 20, 2; 219-233
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterization of transition metal complexes of some novel pyrazolo-chalcone derivatives
Autorzy:
Odedra, Pratap
Rojivadiya, A. J.
Powiązania:
https://bibliotekanauki.pl/articles/1066234.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Pyrazolochalcone derivatives
Thermal gravimetric analysis
Transition metal complexes
Opis:
Some novel pyrazolo-chalcone molecules were synthesized by condensation of pyrzolo aldehyde with appropriate acetophenone. The synthesis of some metal complexes of transition metal was carried out with these pyrazoleo heterocyclic compounds. Each metal complex was synthesized by the reaction of new pyrazolochalcone derivatives with the metal salts such as Co(CH3COO)2·6H2O, Ni(CH3COO)2·6H2O, and Cu(CH3COO)2·2H2O. For the structure elucidation of ligand molecule various spectroscopic techniques such as 1H NMR, IR and mass has been used. The synthesized metal complexes were subjected to thermal study i.e., TGA and DTA in order to check structural conformation of synthesized metal complexes.
Źródło:
World Scientific News; 2019, 131; 242-255
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats
Autorzy:
Najafian, Mahmoud
Ebrahim-Habibi, Azadeh
Yaghmaei, Parichehreh
Parivar, Kazem
Larijani, Bagher
Powiązania:
https://bibliotekanauki.pl/articles/1040323.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
diabetes
hyperglycemia
trans-chalcone
hyperlipidemia
benzylideneacetophenone
alpha-amylase inhibitor
Opis:
trans-Chalcone is the core structure of naringenin chalcone, located halfway in the biosynthesis pathway of flavonoids. Flavonoids have been reported as mammalian alpha-amylase inhibitors, a property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders. As a mammalian alpha-amylase inhibitor in vitro, the putative beneficial effect of trans-chalcone on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1, and the results analyzed with commonly used statistical methods. Significant reduction of blood glucose levels and beneficial effect on dyslipidemia were observed in diabetic rats, as well as reduction of disturbing consequences of diabetes such as high urine volume and water intake. trans-chalcone was observed to have a weight loss-inductive effect, alongside with a reduction in food intake, which is suggestive of a therapeutic potential of this compound in overweight and obese patients.
Źródło:
Acta Biochimica Polonica; 2010, 57, 4; 553-560
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, characterization of biologically potent novel chalcones bearing urea, thiourea and acetamide linkages
Autorzy:
Mewada, N. S.
Shah, D. R.
Chikhalia, K. H.
Powiązania:
https://bibliotekanauki.pl/articles/412032.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Chalcone
urea
thiourea
acetamide
antimicrobial activity and antifungal activity
Opis:
Three series of some novel chalcone based urea, thiourea and acetamide derivatives were designed, synthesized and screened for their antimicrobial and antifungal activities. All the synthesized compounds are first reported. The structures of the compounds were elucidated with the aid of elemental analysis and spectral methods including IR, 1H-NMR spectral data. The prepared compounds were evaluated for antibacterial activity against two Gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus), two Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also investigated for their antifungal activity using the broth micro dilution method. The bioassay results showed that compounds a few compounds showed good to superior in vitro antibacterial and antifungal activity.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 17, 3; 281-294
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, characterization and antifungal activity of some fluorine containing 1,3,5-trisubstituted pyrazoline derivatives
Autorzy:
Manivannan, C.
Santhi, N.
Powiązania:
https://bibliotekanauki.pl/articles/1118150.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
antifungal activity
chalcone
disc diffusion method
pyrazoline
ultrasonic irradiation
Opis:
A series of (E)-1-(4-fluorophenyl)-3-substitutedphenylprop-2-en-1-one (3-7) were ultrasonically prepared by the reaction of 4-fluoroacetophenone with different aromatic aldehydes in the presence of alkali . Reaction of the prepared chalcones (3-7) with 3,4,5-trimethoxybenzohydrazide (8) afforded the corresponding substituted pyrazoline (9-13). Ultrasonic irradiation method provides several advantages over current reaction methodologies, including a simple work-up procedure, shorter reaction times and good yields. All the prepared compounds have been characterized by FT-IR and 1H-NMR spectra. These compounds were screened for their antifungal activity using disc diffusion method. Compound 10 and 11 was found to exhibit the most potent in-vitro anti-fungal activity with against all the fungal strains.
Źródło:
World News of Natural Sciences; 2017, 10; 86-94
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ANTITUMOR EFFECTS OF VANILLIN BASED CHALCONE ANALOGUES IN VITRO
Autorzy:
Luković, Jovan
Mitrović, Marina
Popović, Suzana
Milosavljević, Zoran
Stanojević-Pirković, Marijana
Anđelković, Marija
Zelen, Ivanka
Šorak, Marija
Muškinja, Jovana
Ratković, Zoran
Nikolić, Ivana
Powiązania:
https://bibliotekanauki.pl/articles/895579.pdf
Data publikacji:
2020-02-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
Colorectal cancer
apoptosis
cytotoxicity
Autophagy
chalcones
Opis:
Chalcones, as a large group of organic compounds, are widely implemented in various types of anti-cancer therapeutics. These plant metabolites are present in fruits, vegetables, spices, and have anti-tumor, anti-inflammation, immunomodulation, antibacterial and anti-oxidative activities, as well as many other pharmacological and biological effects. The aim of the present study was to investigate cytotoxic effects, type of cell death and mechanism of action of the newly synthesized vanillin based chalcone analogues, (CH1) and (CH2) on human colon cancer HCT-116 and noncancerous (control) MRC-5 cell lines. In order to compare effects of vanillin based chalcone analogues on investigated cell lines, as reference substances cisplatin (cisPt) and dehydrozingerone (DHZ) were used. Investigation of antitumor effect of chalcone analogues on HCT-116 cells was carried out by three methods MTT assay, flow cytometry and immunofluorescence analysis. The result of our investigation indicated that newly synthesized vanillin based chalcone analogues expressed powerful antitumor effect on cancer cells (HCT-116 cell line), while their effect on healthy cells (MRC-5 cell line) was not statistically significant. Vanillin based chalcone analogues caused overexpression and activation of mitochondrial Bax protein and caspase-3 in HCT-116 cells, indicating that their mechanism of antitumor action was mediated through activation of inner apoptotic pathway. These results indicate possible usefulness of CH1 and CH2 in antitumor therapy whether through its direct cytotoxic effect or as adjuvant therapy. Our results indicate possible usefulness of CH1 and CH2 vanillin based chalcone analogues in antitumor therapy.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 57-67
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Novel s-Triazinyl Schiff Base/Chalcone Congeners: Rational, Synthesis, Antimicrobial and Anti-TB Evaluation
Autorzy:
Lakum, H. P.
Shah, D. R.
Chikhalia, K. H.
Powiązania:
https://bibliotekanauki.pl/articles/412603.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
antimicrobial
Anti-TB
s-Triazine
Schiff base
Chalcone
Opis:
The occurrence of Multi Drug Resistant (MDR) infectious microbial strains has been increased upto alarming level which affects the public health worldwide. To cure this problem, a library of s-triazinyl derivatives comprising schiff base or chalcone motif have been rationalized, synthesized and screened for their in vitro antibacterial activity against five bacterial strains (Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 441, Escherichia coli MTCC 739, Pseudomonas aeruginosa MTCC 741 and Klebsiella pneumoniae MTCC 109) and four fungal strains (Aspergillus niger MTCC 282, Aspergillus fumigates MTCC 343, Aspergillus clavatus MTCC 1323, Candida albicans MTCC 183) using broth dilution technique. All the newly synthesized scaffolds were further evaluated for their in vitro anti-TB efficacy against the tubercular strain (Mycobacterium tuberculosis H37Rv) using Lowenstein-Jensen MIC method. All the derivatives were well characterized by IR, 1H NMR, 13C NMR, elemental analysis as well as mass spectroscopy.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 19, 1; 56-73
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis, Characterization and Mesomorphic Study of new Homologous Chalcone Series
Autorzy:
Jain, B. B.
Patel, R. B.
Powiązania:
https://bibliotekanauki.pl/articles/1182886.pdf
Data publikacji:
2016
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
liquid crystal
smectic
nematic
enantiotropic
mesomorphism
Opis:
A new designed mesogenic homologous series of chalconyl derivative with two ring α-4-Alkoxy benzoyl-β-4/-tetradecyloxy phenyl ethylenehave been synthesized and characterized by a combination of elemental analysis and standard spectroscopic methods. In series, lower members (C5 to C8) exhibit only enantiotropicnematicmesophase but higher members (C10,C12,C14,C16,C18) exhibit enantiotropicnematic as well as smecticmesophase. The nematicmesophase (Thread type) commence from C5 homologue and smecticmesophase(smectic-A type texture) commence from C10 homologue as enantiotropic and persists up to the last member synthesized. Textures are conformed by Polarizing Optical Microscope (POM). The mesomorphic properties of present series were compared with other two structurally similar series to study the effects of change of meta and para position on the mesomorphism.
Źródło:
World Scientific News; 2016, 53, 3; 241-252
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 19

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