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Tytuł:
Heterogenność raka piersi – sprawozdanie z IMPAKT Breast Cancer Conference
Breast cancer heterogeneity – report from IMPAKT Breast Cancer Conference
Autorzy:
Pogoda, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1066065.pdf
Data publikacji:
2013
Wydawca:
Medical Education
Tematy:
HER2
biopsja przerzutu
heterogenność
mTOR
profile molekularne
Opis:
On 2–4 May 2013, in Brussels took place the 5th IMPAKT conference on translational research in breast cancer. The most important issue raised during the conference was the phenomenon of breast cancer heterogeneity, both inter- and intratumour. Heterogeneity of breast cancer was confirmed at the molecular level, showing the differences in the frequency of genetic aberrations (typically PIK3CA, TP53 and ARID1A) in patients with hormone-dependent advanced breast cancer (BOLERO-2 trial). The results of genetic tests were also presented, which showed that in order to reduce the impact of heterogeneity within the tumor, 3 biopsies should be performed from each breast cancer. The most common disorders of PI3K/mTOR pathway were analyzed depending on the molecular type of breast cancer. However, an attempt to determine by immunohistochemistry biomarkers predicting response to combination therapy with everolimus and trastuzumab failed. The results of two studies, which analyzed the value of molecular tests in predicting late recurrence of breast cancer (in 5–10 years after diagnosis), were presented – the best results were achieved with PAM50 and Breast Cancer Index. The latest discoveries in molecular imaging were also presented – it allows for early assessment of treatment efficacy.
W dniach 2–4 maja 2013 r. w Brukseli odbyła się 5. konferencja IMPAKT poświęcona tematyce badań podstawowych nad rakiem piersi. Najważniejszym zagadnieniem poruszanym podczas konferencji było zjawisko heterogenności raka piersi, występujące zarówno między guzami, jak i w obrębie jednego guza. Potwierdzono heterogenność raka piersi na poziomie molekularnym, wykazując różnice w częstości aberracji genetycznych (najczęściej w obrębie PIK3CA, TP53 i ARID1A) w guzach u chorych na hormonozależnego, zaawansowanego raka piersi (badanie BOLERO-2). Przedstawiono również wyniki badań genetycznych, które wykazały, że aby ograniczyć wpływ heterogenności w obrębie guza, należy wykonywać 3 biopsje z każdego raka piersi. Zbadano najczęstsze zaburzenia szlaku PI3K/mTOR w zależności od typu molekularnego raka piersi. Natomiast próba określenia za pomocą immunohistochemii biomarkerów odpowiedzi na terapię skojarzoną ewerolimusem z trastuzumabem nie powiodła się. Zaprezentowano wyniki dwóch prac naukowych, w których analizowano wartość testów molekularnych w predykcji późnego nawrotu raka piersi (5–10 lat od rozpoznania) – najlepsze wyniki osiągnięto w przypadku PAM50 i Breast Cancer Index. Poza tym przedstawiono najnowsze doniesienia w zakresie obrazowania molekularnego pozwalającego na wczesną ocenę skuteczności stosowanej terapii.
Źródło:
OncoReview; 2013, 3, 2; 110-114
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fertility and breast cancer
Autorzy:
Kufel-Grabowska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1064776.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
breast cancer during pregnancy
breast cancer in young women
fertility
fertility preservation strategies
Opis:
Breast cancer is the most common cancer among females worldwide. The mean age of breast cancer patients is > 60 yrs old, and it is seldom found in women < 40 yrs old (6.5%) and in very young women < 35 yrs old (0.6%). In young females, fertility and all its aspects are an additional therapeutic challenge. Before initiating treatment, the oncologist should offer effective contraception to be applied throughout the therapy, bearing in mind that fertility preservation is of utmost importance. When it comes to breast cancer in pregnancy, the attending physician should use a therapy which is safe for both the mother and the foetus. Chemotherapy, radiotherapy, hormonal therapy and immunotherapy can, to a lesser or greater degree, damage the ovarian function resulting in amenorrhea in women < 50 yrs (33–76%). However, owing to fertility preservation strategies, more and more pregnancies are successful, even in breast cancer survivors.
Źródło:
OncoReview; 2016, 6, 4; A157-161
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Breast Cancer in Art Painting
Autorzy:
Forma, Ewa
Bernaciak, Magdalena
Bryś, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/764935.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
breast cancer
art paintings
famous painters
Opis:
Breast cancer is an emotive cancer. It is a disease that affects a visible sexual organ and it is the commonest single cause of death of women between 40 and 60 years of age. Nevertheless, this type of cancer was infrequently depicted in art paintings. In this article the themes from the breast cancer in famous art paintings are discussed.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2010, 6; 61-68
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changing paradigms in breast cancer treatment
Autorzy:
Ali, Shan
Buczek, Dagmara
Jassem, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1196786.pdf
Data publikacji:
2020-12-03
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
breast cancer
sentinel node biopsy
breast-conserving surgery
targeted therapy
molecular profiles
Opis:
In only the past century, the landscape of breast cancer treatment has completely changed. The Halstedian hypothesis of the “contiguous spread” of breast cancer has been replaced by a consideration of its systemic nature. Today, patients with early-stage breast cancer are managed with breast-conserving therapy, which is as effective as mastectomy. Sentinel lymph node biopsy has largely replaced axillary lymph node dissection. Post-operative radiotherapy, chemotherapy and endocrine therapy have increased survival. Pre-operative cytotoxic therapy allows for less extensive surgery and for a curative resection even in more advanced stages. Rapid progress in molecular oncology revealed a large heterogeneity of breast cancer, resulting in a more personalized approach. Targeted therapies directed against epidermal growth factor receptor type 2 (HER2) have improved survival in HER2-positive breast cancer, which was once a poor-prognosis entity. Multi-gene prognostic signatures better predict prognosis and allow many patients to avoid chemotherapy. Personalized treatment has resulted in decreased toxicity and an improved quality of life. Within the past decades, breast cancer has become a good-prognosis malignancy with a five-year survival in the range of 80-85%. Future development of personalized medicine may further refine treatment based on the tumor’s molecular features.
Źródło:
European Journal of Translational and Clinical Medicine; 2020, 3, 2; 53-63
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multimodal Ultrasonic Imaging for Breast Cancer Detection
Autorzy:
Camacho, J.
Medina, L.
Cruza, J. F.
Moreno, J. M.
Fritsch, C.
Powiązania:
https://bibliotekanauki.pl/articles/176695.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
ultrasound imaging
ultrasound tomography
breast cancer
Opis:
Ultrasound is used for breast cancer detection as a technique complementary to mammography, the standard screening method. Current practice is based on reflectivity images obtained with conventional instruments by an operator who positions the ultrasonic transducer by hand over the patient’s body. It is a non-ionizing radiation, pain-free and not expensive technique that provides a higher contrast than mammography to discriminate among fluid-filled cysts and solid masses, especially for dense breast tissue. However, results are quite dependent on the operator’s skills, images are difficult to reproduce, and state-of-the-art instruments have a limited resolution and contrast to show micro-calcifications and to discriminate between lesions and the surrounding tissue. In spite of their advantages, these factors have precluded the use of ultrasound for screening. This work approaches the ultrasound-based early detection of breast cancer with a different concept. A ring array with many elements to cover 360. around a hanging breast allows obtaining repeatable and operator-independent coronal slice images. Such an arrangement is well suited for multi-modal imaging that includes reflectivity, compounded, tomography, and phase coherence images for increased specificity in breast cancer detection. Preliminary work carried out with a mechanical emulation of the ring array and a standard breast phantom shows a high resolution and contrast, with an artifact-free capability provided by phase coherence processing.
Źródło:
Archives of Acoustics; 2012, 37, 3; 253-260
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Web–based framework for breast cancer classification
Autorzy:
Bruździński, T.
Krzyżak, A.
Fevens, T.
Jeleń, Ł.
Powiązania:
https://bibliotekanauki.pl/articles/91866.pdf
Data publikacji:
2014
Wydawca:
Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
Tematy:
breast cancer
classification
cytological image
aspiration biopsy
feature vector
classifier
multilayer perceptron
segmentation algorithm
Opis:
The aim of this work is to create a web-based system that will assist its users in the cancer diagnosis process by means of automatic classification of cytological images obtained during fine needle aspiration biopsy. This paper contains a description of the study on the quality of the various algorithms used for the segmentation and classification of breast cancer malignancy. The object of the study is to classify the degree of malignancy of breast cancer cases from fine needle aspiration biopsy images into one of the two classes of malignancy, high or intermediate. For that purpose we have compared 3 segmentation methods: k-means, fuzzy c-means and watershed, and based on these segmentations we have constructed a 25–element feature vector. The feature vector was introduced as an input to 8 classifiers and their accuracy was checked. The results show that the highest classification accuracy of 89.02 % was recorded for the multilayer perceptron. Fuzzy c–means proved to be the most accurate segmentation algorithm, but at the same time it is the most computationally intensive among the three studied segmentation methods.
Źródło:
Journal of Artificial Intelligence and Soft Computing Research; 2014, 4, 2; 149-162
2083-2567
2449-6499
Pojawia się w:
Journal of Artificial Intelligence and Soft Computing Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Epidemiology of breast cancer in Podkapackie voivodship
Autorzy:
Gustalik, Joanna
Bartusik-Aebisher, Dorota
Ostańska, Elżbieta
Przyczyna, Piotr
Osuchowski, Michał
Aebisher, David
Galiniak, Sabina
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454657.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
breast cancer
statistics
epidemiology
podkarpackie voivodship
Opis:
Introduction. Breast cancer is the second most prevalent reason for cancer deaths after lung cancer. Incidence rates have increased worldwide. Aim. To present epidemiology of breast cancer in Podkapackie voivodship. Material and methods. This analysis was performed using a systematic literature search. Results. In the Podkarpackie voivodship up until 2014, the incidence rate of female breast cancer was rising and in 2015 it dropped by 68 cases. Even though the survival rate is increasing, it is still one of the leading causes of cancer deaths placing second after lung cancer. Conclusion. Mortality rate, unfortunately, rose gradually. This shows that even though there is a National Health Program aiming at breast cancer awareness and prevention, it is still not enough to reduce the number of breast cancer deaths.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 242-245
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Primary and secondary prevention of breast cancer
Autorzy:
Kolak, Agnieszka
Kamińska, Marzena
Sygit, Katarzyna
Budny, Agnieszka
Surdyka, Dariusz
Kukiełka-Budny, Bożena
Burdan, Franciszek
Powiązania:
https://bibliotekanauki.pl/articles/987031.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
breast cancer
primary and secondary prevention
risk factors
life style
mammography
modern diagnostics methods
Opis:
Introduction. Breast cancer is the most common cancer among women and is the second cancer frequently occurring worldwide of newly-diagnosed cancers. There is much evidence showing the influence of life style and environmental factors on the development of mammary gland cancer (high-fat diet, alcohol consumption, lack of physical exercise), the elimination of which (primary prevention) may contribute to a decrease in morbidity and mortality. Secondary prevention, comprising diagnostic tests (e.g. mammography, ultrasonography, magnetic resonance imaging, breast self-examination, as well as modern and more precise imaging methods) help the early detection of tumours or lesions predisposing to tumours. Objective. The aim of this study paper is to review current knowledge and reports regarding primary and secondary prevention of breast cancer. State of knowledge. It is estimated that nearly 70% of malign tumours are caused by environmental factors, whereas in breast cancer this percentage reaches 90–95%. There are national programmes established in many countries to fight cancer, where both types of prevention are stressed as serving to decrease morbidity and mortality due to cancers. Conclusions. Cancer prevention is currently playing a key role in the fight against the disease. Behaviour modification, as well as greater awareness among women regarding breast cancer, may significantly contribute towards reducing the incidence of this cancer. Another important aspect is the number of women undergoing diagnostic tests, which still remains at an unsatisfactory level.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neoadjuvant therapy in breast cancer – objectives and tasks
Autorzy:
Ostańska, Elżbieta
Bartusik-Aebisher, Dorota
Aebisher, David
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454710.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
neoadjuvant therapy (NCT)
breast cancer (BC)
triple negative breast cancer (TNBC)
Opis:
Introduction. Neoadiuvant therapy (NCT) in the treatment of breast cancer is employed for patients with early stage disease or with inoperable disease. NCT can decrease the tumor volume. It can facilitate breast conservation therapy. Response to NCT is a strong predictor of outcome breast cancer (BC). Direct target therapies has markedly improved the result of treatment BC. Aim. Therapy for breast cancer continues to improve. The importance of tumor burden on local control rates will be in the future. Material and methods. This analysis was performed using a systematic literature search. Results. The latest scientific reports give hope for greater safety and a better life for patients based on optimized and effective therapy. Conclusion. Currently, improving the effectiveness of breast cancer treatment is mainly related to the optimal use of classic therapeutic strategies. New classes of substances have been approved for treatment or are in advanced stages of clinical development.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 153-156
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of nurse in the breast cancer education
Autorzy:
Cetlova, Lada
Dvorakova, Vlasta
Powiązania:
https://bibliotekanauki.pl/articles/2141042.pdf
Data publikacji:
2011
Wydawca:
Instytut Studiów Międzynarodowych i Edukacji Humanum
Tematy:
education
breast cancer
patient
nurse
Opis:
Incidence of female breast cancer in our population remains very high and the incidence increase every year. Breast cancer and following demanding oncological treatment extensively influence life of female patients. It intervene biological, psychical and social life of patient. Objective of our research was to check how women are informed about preventive precautions and how they are following them. Our research sample were randomly selected women of all age groups. Our results showed that it is necessary to increase activity in the area of education, increase personal responsibility in area of breasts self-examination and better inform about the influence of obesity to breast cancer incidence. Considering our previous experience in health care we were surprised that the role of nurse in education process is very low. We think that general nurses have enough opportunities to use daily contacts with patients to inform and lecture them.
Źródło:
Humanum. Międzynarodowe Studia Społeczno-Humanistyczne; 2011, 2(7); 315-320
1898-8431
Pojawia się w:
Humanum. Międzynarodowe Studia Społeczno-Humanistyczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stomach metastasis from breast cancer-mimicking linitis plastica
Autorzy:
Czerko, Katarzyna
Ostrowski, Michał
Bodnar, Lubomir
Powiązania:
https://bibliotekanauki.pl/articles/3200732.pdf
Data publikacji:
2022-09-30
Wydawca:
Medical Education
Tematy:
breast cancer
gastric metastases
Opis:
We report a rare case of metastatic gastric cancer from invasive carcinoma of the breast (BC) as the first symptom of disease-mimicking primary gastric linitis plastica.
Źródło:
OncoReview; 2022, 12, 3; 65-67
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Off-label drug use in breast cancer therapy
Autorzy:
Jankowski, Tomasz
Urbaniak, Monika
Powiązania:
https://bibliotekanauki.pl/articles/773466.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
breast cancer
capecitabine
chemotherapy
liposomal doxorubicin
metronomic vinorelbine
off-label
Opis:
Breast cancer is one of the most common malignancies across the world, including Poland. Chemotherapy plays an important part in the treatment of the disease. Most of the available chemotherapy drugs and regimens have undergone randomized clinical studies and have been registered for that specific indication. However, a number of drugs are used in an off-label manner, i.e. outside the officially approved product specifications. The paper discusses the use of several off-label therapies in breast cancer in order to demonstrate that such treatment may be well-grounded and indeed turns out beneficial in many cases. It describes the use of liposomal doxorubicin in pre- and post-operative treatment, capecitabine for incomplete efficacy of preoperative treatment, and the administration of metronomic vinorelbine. Moreover, the paper is aimed at demonstrating the legal basis and the principles of marketing authorization of off-label drug use.
Źródło:
OncoReview; 2017, 7, 2; 83-87
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acceptance of illness by women with breast cancer
Autorzy:
Cipora, E.
Konieczny, M.
Sobieszczański, J.
Powiązania:
https://bibliotekanauki.pl/articles/2081561.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
breast cancer
demographic factors
AIS Scale
acceptance of illness
Opis:
Introduction. Despite great progress in the diagnostics and treatment, breast cancer still remains the most frequently diagnosed malignant cancer in women. The outcomes of cancer treatment depend, to a considerable extent, on the degree of acceptance of the illness. The objective of the study was determination of the level of acceptance of the disease among the examined women with breast cancer. Materials and method. The study covered a group of 231 women who received treatment for breast cancer in the Rev. Bronislaw Markiewicz Subcarpathian Oncology Centre in Brzozow, south-eastern Poland, and conducted by the method of a diagnostic survey, using an author constructed questionnaire and the standard Acceptance of Illness Scale, adapted by Z. Juczyński. Statistical analyses were performed using the software IBM SPSS v. 21.0.0.1. The p values p≤0.05 were considered statistically significant. Results. The mean level of acceptance of the illness in the examined group of women was 26.53 (SD = 7.71; Me = 26). The largest number of respondents (50.6%) obtained scores within the range of 20–29, according to the AIS Scale. From among the adopted variables, the level of acceptance of the illness significantly varied according to age and occupational activity. However, no such differences were confirmed according to the place of residence, marital status, education level, or the type of occupation performed. Conclusions. In the examined group of women, a mediocre level of acceptance of cancer was observed. The respondents’ age and occupational situation exerted a significant effect on the level of acceptance of the illness. The results of the study should be considered as satisfactory because the number of women with a high level of acceptance of breast cancer was more than twice as high as those ones with a low acceptance of the disease.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 1; 167-171
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Feature selection for breast cancer malignancy classification problem
Autorzy:
Filipczuk, P.
Kowal, M.
Marciniak, A.
Powiązania:
https://bibliotekanauki.pl/articles/333614.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
wybór funkcji
klasyfikacja
rak piersi
feature selection
classification
breast cancer
Opis:
The paper provides a preview of some work in progress on the computer system to support breast cancer diagnosis. Diagnosis approach is based on microscope images of the FNB (Fine Needle Biopsy) and assumes distinguishing malignant from benign cases. Studies conducted focus on two different problems, the first concern the extraction of morphometric parameters of nuclei present in cytological images and the other concentrate on breast cancer nature classification using selected features. Studies in both areas are conducted in parallel. This work is devoted to the problem of feature selection from the set of determined features in order to maximize the accuracy of classification. Morphometric features are derived directly from a digital scans of breast fine needle biopsy slides and are computed for segmented nuclei. The quality of feature space is measured with four different classification methods. In order to illustrate the effectiveness of the approach, the automatic system of malignancy classification was applied on a set of medical images with promising results.
Źródło:
Journal of Medical Informatics & Technologies; 2010, 15; 193-199
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rak piersi w ciąży
Breast cancer in pregnancy
Autorzy:
Karczmarek-Borowska, Bożenna
Golon, Kamila
Powiązania:
https://bibliotekanauki.pl/articles/437712.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
nowotwór złośliwy piersi
ciąża
diagnostyka
leczenie
malignant breast cancer
pregnancy
diagnostics
treatment
Opis:
Rak piersi w ciąży to nowotwór rozpoznany w okresie do pierwszego roku po zakończeniu ciąży lub w okresie laktacji. Wpływ ciąży na proces nowotworowy nie jest do końca wyjaśniony. Rozpoznanie choroby opiera się na podstawie badań wykonywanych standardowo jak u kobiet niebędących w ciąży, z wyjątkiem stosowania technik obrazowania promieniowaniem jonizującym oraz rezygnacji z użycia kontrastu. Leczenie nowotworu przebiega podobnie jak u innych pacjentek, lecz zaleca się mastektomię dopiero po ukończeniu pierwszego trymestru ciąży. Nie zaleca się leczenia oszczędzającego z powodu przeciwwskazań do radioterapii uzupełniającej w trakcie trwania ciąży. Na podstawie badań wykazano, że bezpieczne są schematy chemioterapii oparte na antracyklinach oraz cyklofosfamidzie. Inne cytostatyki oraz hormonoterapia są przeciwwskazane z powodu poważnych uszkodzeń płodu. Leczenie wspomagające w postaci leków przeciwwymiotnych, przeciwbólowych jest dopuszczalne, jednak pod pewnymi warunkami. Po zakończeniu ciąży nie jest zalecane karmienie piersią podczas stosowania chemioterapii, leczenia biologicznego oraz hormonoterapii, ponieważ wiele leków przenika do mleka matki. Nie ustalono ostatecznie wpływu ciąży na rokowanie raka piersi. Ponieważ zmiany gruczołu piersiowego podczas ciąży i karmienia traktowane są jako fizjologiczne, zdarza się, że opóźnienie diagnozy sięga nawet 7 miesięcy. Uważa się, że przerwanie ciąży nie poprawia wyników leczenia. Kolejną ciążę można rozważać po około 3 latach od zakończenia leczenia przeciwnowotworowego, po wykluczeniu wznowy choroby oraz przerzutów odległych.
Breast cancer in pregnancy is a neoplasm diagnosed during the first year postpartum or during lactation. Effect of pregnancy on the neoplastic process is not fully understood. The diagnosis is based on the tests performed as in case of non-pregnant women with the exception of the use of ionizing radiation imaging techniques and use of contrast agent. The course of cancer treatment is the same as for other patients, but mastectomy is recommended after the first trimester of pregnancy. Conservative treatment is not recommend due to contraindications for radiotherapy during pregnancy. The studies have demonstrated that chemotherapy regimens based on anthracycline and cyclophosphamide are safe. Other cytotoxic drugs and hormonal therapy are contraindicated because of severe damage to the fetus. Adjunctive therapy in the form of antiemetics, analgesics is permitted, but under certain conditions. Breast-feeding after labour is not recommended during chemotherapy, hormonal therapy and biological therapy, because many drugs are excreted into breast milk. Definite effect of pregnancy on breast cancer prognosis has not been established. Since changes in the mammary gland during pregnancy and lactation are considered as physiological, it happens that diagnosis is delayed even up to 7 months. It is believed that abortion does not improve treatment results. Another pregnancy can be considered only after 3 years when anticancer treatment is finished, cancer relapse and distant metastases are ruled out.
Źródło:
Medical Review; 2014, 2; 182-189
2450-6761
Pojawia się w:
Medical Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Elektrochemioterapia w nowotworach piersi
Electrochemotherapy in breast cancer
Autorzy:
Piechocki, Jacek
Mazur, Sławomir
Nowecki, Zbigniew I.
Powiązania:
https://bibliotekanauki.pl/articles/1030145.pdf
Data publikacji:
2016
Wydawca:
Medical Communications
Tematy:
breast cancer
electrochemotherapy
local recurrence
elektrochemioterapia
rak piersi
wznowa miejscowa
Opis:
Electrochemotherapy is a local therapy method reserved for cases not subject to surgery in advanced surface-localized cancers in the integuments. It may be applied in treating primary skin neoplasms (cancer and melanoma) as well as metastases of other neoplasms to the skin/hypodermis not qualified for another therapy (e.g. local removal or isolated limb perfusion, radiotherapy), regardless of the histological type of the neoplasm. It is a palliative type of treatment, and its objective is to obtain local control over cancerous lesions deteriorating the quality of life of the patients (infections, hemorrhages, limb function limitation). In selected cases, it is possible to obtain a long-term local control (e.g. in advanced, unresectable or qualifying to an extensive procedure on scalp and neck neoplasms and breast cancers with extensive dermis infiltration, reacting poorly to systemic treatment). Especially local breast cancer recurrence, frequently of large area or multiple with tissue infiltration, persisting despite systemic treatment, may be subject to electrochemotherapy. It especially applies to patients with disseminated cancer. In the paper, the authors are summarizing their experience in the application of that method among patients with breast cancer.
Elektrochemioterapia jest metodą terapii miejscowej zarezerwowaną dla przypadków nieoperacyjnych w zaawansowanych nowotworach zlokalizowanych powierzchownie w powłokach ciała. Może być stosowana zarówno w leczeniu pierwotnych nowotworów skóry (raki i czerniaki), jak i przerzutów innych nowotworów do skóry/tkanki podskórnej niekwalifikujących się do innej terapii (np. miejscowego wycięcia lub izolowanej perfuzji kończynowej, radioterapii), niezależnie od typu histologicznego nowotworu. Jest to z założenia leczenie paliatywne, a jego celem jest uzyskanie miejscowej kontroli nad zmianami nowotworowymi pogarszającymi jakość życia chorych (zakażenia, krwawienia, ograniczenie funkcji kończyn). W wybranych przypadkach możliwe jest uzyskanie długotrwałej kontroli miejscowej (np. w zaawansowanych, nieresekcyjnych lub kwalifikujących się do rozległego zabiegu okaleczającego nowotworach skóry głowy i szyi oraz rakach piersi z rozległym naciekiem skóry, słabo reagujących na leczenie systemowe). Zwłaszcza wznowy miejscowe raka piersi, nierzadko o dużej powierzchni lub liczne z naciekiem tkanek, utrzymujące się pomimo leczenia systemowego, mogą być poddane elektrochemioterapii. Dotyczy to szczególnie chorych z rozsianą chorobą nowotworową. W niniejszej pracy autorzy podsumowują własne doświadczenie w zastosowaniu tej metody u chorych na raka piersi.
Źródło:
Current Gynecologic Oncology; 2016, 14, 1; 5-12
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physiotherapy in women after breast cancer treatment – review
Autorzy:
Skutnik, K.
Ustymowicz, W.
Zubrewicz, K.
Zińczuk, J.
Kamińska, D.
Pryczynicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/1918836.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
breast cancer
rehabilitation
mastectomy
physiotherapy
Opis:
Introduction: Breast cancer is the most common malignant tumor in women in the Polish region. Surgery is a basic method of breast cancer treatment. Surgery often carries a lot of unwanted changes as follows: limitation of mobility in the shoulder joint on the operated side, secondary lymphoedema, post mastectomy pain syndrome (PMPS), reduction of muscle strength or disorders in body posture. Therefore, the implementation of physiotherapeutic activities that are designed to prevent and eliminate postoperative complications seems very important. The main aim of this work was to present physiotherapeutic management in women after mastectomy based on the analysis of available literature. The physiotherapeutic process can be divided into three periods: early hospital, early ambulatory and the late ambulatory period. In the first period, active slow exercises, self-support of the upper limb on the operated side and breathing exercises on the thoracic track are used to prevent circulatory disorders, pulmonary complications, and edema. The early ambulatory period includes corrective exercises, general improvement exercises, stretching and learning of automatic massage of the upper limb of the operated side. The last period should be enriched by recreational methods of physical activity such as swimming, cycling or Nordic walking to maintain physical fitness, proper mobility of the shoulder girdle and improve the patient's psychophysical state. It is very important the patient regular continues the rehabilitation program after curing of breast cancer as well. In the case of secondary lymphoedema of the upper limb, comprehensive rehabilitation physiotherapy is used, consisting of manual lymphatic drainage, healing exercises, compression therapy, and skin care. Conclusions: Physiotherapy in women after breast cancer surgery is a complex and long-term process. Physiotherapeutic methods are effective in treating complications after surgery of breast cancer surgery. It is necessary to constantly update the physio-therapy knowledge in women after breast cancer surgery.
Źródło:
Progress in Health Sciences; 2019, 1; 162-168
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ciąża po raku piersi
Pregnancy following breast cancer
Autorzy:
Skrzypczyk-Ostaszewicz, Anna
Jagielska, Beata
Śpiewankiewicz, Beata
Maździarz, Agnieszka
Jaxa-Larecka, Dominika
Powiązania:
https://bibliotekanauki.pl/articles/1030158.pdf
Data publikacji:
2014
Wydawca:
Medical Communications
Tematy:
breast cancer
estrogen receptor
motherhood
pregnancy
recurrence
ciąża
macierzyństwo
rak piersi
receptor estrogenowy
wznowa
Opis:
Many young patients having undergone radical treatment of breast cancer start considering motherhood at some point. The desire to become a mother may appear within a differing period from the completion of cancer therapy, yet it seems that regardless of the period, it is almost inevitably accompanied by major-level anxiety and stress. The decision about whether to become pregnant turns out a very difficult one, due to numerous doubts, uncertainties, and myths that have been commonly accepted concerning the safety of pregnancy for the future mother (i.e. the risk of cancer recurrence while pregnant), the effect of the undergone chemotherapy on the fetus, and breastfeeding-related issues. At the moment the disease is diagnosed, it is extremely rare for a young woman to immediately look out into her future in terms other than mere survival chances. The shock and the fear which are bound with the diagnosis hardly allow to ponder on the woman’s functioning following the treatment, or on her chances to return to all social roles. In some patients the fear of cancer recurrence and of the potential inability to raise the child themselves is so grave, it never allows them to make the decision to become mothers. Psycho-oncologic counseling, therefore, may have crucial impact over the choices made by breast cancer survivors, and not only should it be made available while patients are still tackling the diagnosis and treatment, but well beyond that period, throughout the healing process and follow-up monitoring time. The recent reports from the past few years seem to clarify many doubts and uncertainties, and this paper brings together the most important results of the new research available.
Wiele młodych pacjentek po radykalnym leczeniu raka piersi zaczyna w pewnym momencie rozważać macierzyństwo. Chęć urodzenia dziecka pojawia się w różnym czasie po zakończeniu leczenia, ale wydaje się, że niezależnie od tego okresu niemal zawsze pociąga za sobą lęk i stres. Decyzja o ciąży okazuje się bardzo trudna – wynika to z licznych niejasności i pokutujących mitów dotyczących bezpieczeństwa ciąży dla przyszłej matki (czyli ryzyka nawrotu choroby), wpływu przebytej przez nią chemioterapii na płód i kwestii związanych z karmieniem piersią. W chwili rozpoznania choroby nowotworowej młoda kobieta bardzo rzadko od razu podejmuje temat swojej przyszłości w kontekście innym niż przeżycie. Szok i strach, bezsprzecznie towarzyszące diagnozie, zwykle nie pozwalają na rozważania o przyszłym funkcjonowaniu kobiety po leczeniu i powrocie do wszystkich ról społecznych. U części pacjentek lęk przed wznową raka i ewentualną niemożnością wychowania dziecka jest tak nasilony, że nigdy nie decydują się na macierzyństwo. Poradnictwo psychoonkologiczne może mieć zatem znaczący wpływ na wybory dokonywane przez kobiety po zakończeniu leczenia raka piersi – powinno być dostępne nie tylko podczas zmagania się z diagnozą i leczeniem, lecz także długo później, w okresie zdrowienia i obserwacji po terapii. Doniesienia z kilku ostatnich lat rozwiewają wiele wątpliwości, a niniejsza praca stanowi podsumowanie najważniejszych wyników nowych badań.
Źródło:
Current Gynecologic Oncology; 2014, 12, 1; 25-30
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The presence of HPV DNA in breast cancer
Autorzy:
Kolodziej-Andrejuk, S.
Macielag, P.
Patyra, K.
Mandziuk, S.
Pachnia, D.
Mazurkiewicz, M.
Polz-Dacewicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/3554.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Źródło:
Journal of Pre-Clinical and Clinical Research; 2013, 07, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determinants of women’s behavior in breast cancer prevention
Autorzy:
Nagórska, Małgorzata
Aksamit, Magdalena
Krygowska, Krystyna
Bassara-Nowak, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454727.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
attitudes
breast cancer
knowledge
prophylaxis
Opis:
Introduction. According to statistics, breast cancer is the second leading cause of death in Poland. Progress in treatment and diagnosis gives an opportunity of a quick diagnosis, but women are reluctant to undergo prophylaxis screening. Aim. To identify women’s attitudes about breast cancer prophylaxis. Material and methods. The diagnostic survey was conducted in a group of 200 women. The research tool was the questionnaire developed by the authors. Results. Knowledge about breast cancer and prophylaxis was on an average level. Nearly half of the women surveyed (45.5%) declared that they do not ask for a breast examination while visiting a gynecologist. Only 26.8% of the surveyed women were systematically subjected to preventive examinations for breast cancer, while 18.7% of them performed breast self-examination. Every fifth respondent used invitation for a free mammogram. Conclusion. The women’s knowledge about breast cancer is average, but it does not translate into their attitudes towards the prevention of this cancer. Most women niether perform breast self-examination nor benefit from free prophylaxis programs. Younger respondents most often use the Internet. Education and place of residence do not affect the participation of women in preventive examinations for breast cancer.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 123-130
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Paraneoplastic neurological syndrome in the course of breast cancer
Autorzy:
Ciszewska, Anna
Głogowski, Łukasz
Witkoś, Andrzej
Rusinowska, Zofia
Nowakowska-Zajdel, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1065222.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
breast cancer
paraneoplastic neurological syndromes
stiff person syndrome
Opis:
Paraneoplastic neurological syndromes (PNS) are a group of rarely observed disorders, accompanying about 1% of cancer diseases. They have a typically aggressive course, leading to profound and essentially irreversible disability. The pathogenic cause behind PNS is damage of the nervous system structures as a consequence of the body’s immunological reaction induced by cancer. Onconeural antibodies generated as part of the reaction target the tumour tissues, but also the regular nervous tissue recognized as antigens. Presence of onconeural antibodies reveals a 50–60% sensitivity and 100% specificity in diagnosing PNS. Imaging and laboratory tests have a limited impact on diagnosis. What is crucial is the analysis of clinical systems following Graus’s criteria (elaborated in 2004). In the case presented here, the patient underwent treatment in many neurological departments due to the symptoms of progressive damage of the nervous system. She was eventually diagnosed with the stiff person syndrome related to breast cancer. In spite of the treatment, including an efficacious oncological therapy, the severe neurological deficit resulted in serious motor disability.
Źródło:
OncoReview; 2015, 5, 2; A76-80
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nuclei segmentation for computer-aided diagnosis of breast cancer
Autorzy:
Kowal, M.
Filipczuk, P.
Powiązania:
https://bibliotekanauki.pl/articles/330248.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
computer aided diagnosis
breast cancer
pattern analysis
fast marching
diagnostyka wspomagana komputerowo
rak piersi
analiza obrazu
Opis:
Breast cancer is the most common cancer among women. The effectiveness of treatment depends on early detection of the disease. Computer-aided diagnosis plays an increasingly important role in this field. Particularly, digital pathology has recently become of interest to a growing number of scientists. This work reports on advances in computer-aided breast cancer diagnosis based on the analysis of cytological images of fine needle biopsies. The task at hand is to classify those as either benign or malignant. We propose a robust segmentation procedure giving satisfactory nuclei separation even when they are densely clustered in the image. Firstly, we determine centers of the nuclei using conditional erosion. The erosion is performed on a binary mask obtained with the use of adaptive thresholding in grayscale and clustering in a color space. Then, we use the multi-label fast marching algorithm initialized with the centers to obtain the final segmentation. A set of 84 features extracted from the nuclei is used in the classification by three different classifiers. The approach was tested on 450 microscopic images of fine needle biopsies obtained from patients of the Regional Hospital in Zielona Góra, Poland. The classification accuracy presented in this paper reaches 100%, which shows that a medical decision support system based on our method would provide accurate diagnostic information.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2014, 24, 1; 19-31
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Severe aortic stenosis in a patient with breast cancer
Autorzy:
Mańczak, Rafał
Wilk, Michał
Walaszkowska-Czyż, Anna
Florczyk, Michał
Szmit, Sebastian
Powiązania:
https://bibliotekanauki.pl/articles/1064894.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
anthracyclines
aortic stenosis
aortic valve replacement
breast cancer
echocardiography
Opis:
We present a case of 68-year-old female with severe symptomatic aortic stenosis and locally advanced breast cancer disqualified from mastectomy due to heart failure and from aortic valve replacement due to malignant neoplasm. The patient received neoadjuvant chemotherapy without anthracyclines. The aortic valve replacement was performed and then mastectomy and lymphadenectomy were made without hemodynamic complications. Adjuvant hormonotherapy was started. During 42 months of follow-up the patient remained free of recurrent cancer disease as well as no progression of heart failure was observed.
Źródło:
OncoReview; 2016, 6, 2; A49-56
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rak piersi współistniejący z ciążą
Breast cancer in pregnancy
Autorzy:
Skrzypczyk-Ostaszewicz, Anna
Jagielska, Beata
Śpiewankiewicz, Beata
Osuch, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1030157.pdf
Data publikacji:
2014
Wydawca:
Medical Communications
Tematy:
breast cancer
chemotherapy
delivery
fetus
hormone therapy
pregnancy
sentinel lymph node
chemioterapia
ciąża
hormonoterapia
poród
płód
rak piersi
węzeł wartowniczy
Opis:
Breast cancer is one of the most common cancers to complicate pregnancy. Up until recently, such diagnosis was almost invariably bound with an abortion with all its possible psychological and ethical consequences for the patient, her family, and treating physicians. Throughout the past few years, the considerable progress in medical knowledge and experience has allowed a radical change in the situation of this very special patient group. These days, women may continue with the pregnancy, yet at the same time be effectively and safely treated, in a very close adherence to standards applied in the treatment of non-pregnant patients. The diagnostics of breast cancer in pregnant patients largely meets the generally accepted standards of detecting and staging the disease, apart from a few exceptions mostly related to fetus safety. The differences concern e.g. the sentinel lymph node evaluation procedure and some imaging methods. Whether the patient qualifies for treatment as well as therapeutic decisions depend on the gestational age and the advancement of the disease, with some treatment procedures imperatively postponed until postpartum. Certain chemotherapy regimens have been proved safe during pregnancy, even though up until recently they were considered toxic and impossible to use (FAC, FEC, taxoids). It has also been shown that, unless obstetric indications for caesarean section exist, in most cases the pregnancy does not need to be terminated prematurely. No oncologic counter-indications for a vaginal delivery exist either. This paper aims to bring together and sum up the body of knowledge arising from the recent publications which have facilitated diagnostic and therapeutic standards to be followed in these infrequent, yet exceedingly complex, clinical situations.
Rak piersi to jeden z najczęstszych nowotworów wikłających ciążę. Jeszcze niedawno takie rozpoznanie wiązało się prawie zawsze z aborcją, ze wszystkimi jej konsekwencjami psychologicznymi i etycznymi dla chorej, jej bliskich i lekarzy. W kilku ostatnich latach, wraz ze znacznym rozwojem wiedzy i doświadczenia, sytuacja tej szczególnej grupy pacjentek diametralnie się zmieniła: dzisiaj kobiety mogą zachować ciążę, a jednocześnie skutecznie i bezpiecznie się leczyć – w sposób bardzo zbliżony do leczenia stosowanego u pacjentek niebędących w ciąży. Diagnostyka raka piersi u ciężarnej pokrywa się w znacznej mierze z ogólnie obowiązującymi standardami wykrywania i oceny zaawansowania tej choroby, poza kilkoma odstępstwami, związanymi przede wszystkim z bezpieczeństwem płodu. Różnice dotyczą m.in. procedury oceny węzła wartowniczego i części badań obrazowych. Kwalifikacja do leczenia i decyzje terapeutyczne zależą od zaawansowania ciąży i zaawansowania choroby, a niektóre procedury lecznicze muszą zostać bezwzględnie odroczone na czas po porodzie. Udowodniono bezpieczeństwo stosowania w czasie ciąży wybranych schematów chemioterapii jeszcze do niedawna uważanych za toksyczne i niemożliwe do wykorzystania u ciężarnej (FAC, FEC, taksoidy). Wykazano również, że – o ile nie istnieją położnicze wskazania do cesarskiego cięcia – w większości przypadków ciąża nie musi być rozwiązywana przed terminem, podobnie jak nie ma onkologicznych przeciwwskazań do porodu siłami natury. Niniejsza praca podsumowuje wiedzę płynącą z publikacji, które ukazały się w ostatnim czasie i pozwoliły na opracowanie standardów postępowania diagnostyczno-terapeutycznego w tych nieczęstych, ale jednocześnie bardzo skomplikowanych sytuacjach klinicznych.
Źródło:
Current Gynecologic Oncology; 2014, 12, 1; 14-24
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anti-breast cancer potential of honey: a narrative review
Autorzy:
Qadirifard, Mohammad Sadegh
Fathabadi, Amirhossein
Hajishah, Hamed
Gholami, Kosar
Abbasi, Mohammadmehdi
Sami, Nafiseh
Zo, Mostafa Mahmoudi
Kadkhodaei, Fateme
Sina, Mahla
Ansari, Arina
Rahimi, Zahra
Deravi, Niloofar
Powiązania:
https://bibliotekanauki.pl/articles/2047807.pdf
Data publikacji:
2022-03-31
Wydawca:
Medical Education
Tematy:
honey
breast cancer
anticancer
complementary medicine
Opis:
Cancer is responsible for the death of millions of people all around the world. Among the large group of cancers, the prevalence of breast cancer is highest in women. Therapeutic interventions, including removal surgery, radiation therapy, hormone therapy, and chemotherapy which is largely used, may cause adverse effects on the quality of patients’ life. This fact has encouraged researchers to find natural substances such as honey to overcome harmful effects. Nowadays, honey is recommended for plenty of abnormalities because of its antioxidant, anti-inflammatory, and antimicrobial properties. Various studies have been conducted to explore the anticancer benefits of different types of honey from different origins. In this review, we are going to summarize in-vitro, animal, and human studies on the anti-breast cancer potential of honey.
Źródło:
OncoReview; 2022, 12, 1; 5-15
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Breast cancer diagnosis via fuzzy clustering with partial supervision
Autorzy:
Przybyła, T.
Powiązania:
https://bibliotekanauki.pl/articles/1965815.pdf
Data publikacji:
2004
Wydawca:
Politechnika Gdańska
Tematy:
robust method
fuzzy clustering
weighted myriad
partial supervision
Opis:
A new clustering method of fuzzy c-myriad clustering with partial supervision is presented in this paper. The proposed method has been applied to breast cancer diagnosis data obtainted from the University of Wisconsin. The data set contains 699 cases of breast cancer, with each instance described by 10 features.
Źródło:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2004, 8, 2; 193-198
1428-6394
Pojawia się w:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Segmentation of breast cancer fine needle biopsy cytological images
Autorzy:
Hrebień, M.
Steć, P.
Nieczkowski, T.
Obuchowicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/907946.pdf
Data publikacji:
2008
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
segmentacja obrazów
algorytm działów wodnych
aktywne kontury
obraz cytologiczny
transformata Hough'a
automat komórkowy
metoda GrowCut
cytological image segmentation
Hough transform
watershed algorithm
active contours
cellular automata GrowCut method
Opis:
This paper describes three cytological image segmentation methods. The analysis includes the watershed algorithm, active contouring and a cellular automata GrowCut method. One can also find here a description of image pre-processing, Hough transform based pre-segmentation and an automatic nuclei localization mechanism used in our approach. Preliminary experimental results collected on a benchmark database present the quality of the methods in the analyzed issue. The discussion of common errors and possible future problems summarizes the work and points out regions that need further research.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2008, 18, 2; 159-170
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Everolimus with exemestane in elderly breast cancer patients – case report
Autorzy:
Jagiełło-Gruszfeld, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1065836.pdf
Data publikacji:
2014
Wydawca:
Medical Education
Tematy:
breast cancer
elderly
everolimus
exemestan
Opis:
Treating elderly patients suffering from metastatic breast cancer still constitutes a significant therapeutic problem. The possibility of administering everolimus in combination with exemestane appears to be a promising therapeutic option in the case of hormone-dependent cancers, without HER2 receptor overexpression.
Źródło:
OncoReview; 2014, 4, 1; A33-36
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The use of fulvestrant in patients with advanced breast cancer
Autorzy:
Kufel-Grabowska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1035843.pdf
Data publikacji:
2018
Wydawca:
Medical Education
Tematy:
breast cancer
fulvestrant
hormone therapy
Opis:
Breast cancer is the most common malignancy in women in Poland and the entire world, but thanks to early diagnostics and efficacious therapeutic methods, its prognosis is good. In some patients with advanced breast cancer, long-term survival is observed, which is why it is essential to select the most appropriate therapy, and to follow up on the course of disease and possible adverse events related to the treatment applied. The slow development of hormone-receptor-positive cancer, and a multitude of therapeutic options constitute a real challenge in palliative treatment. The use of fulvestrant resulted in a good response in both of the presented cases, and did not in any way comprise the daily lives of the patients over a long period of time.
Źródło:
OncoReview; 2018, 8, 1; 15-18
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The young breast cancer patient therapy – new opportunities, new challenges
Autorzy:
Załuska-Kusz, Joanna
Kufel-Grabowska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1035689.pdf
Data publikacji:
2019
Wydawca:
Medical Education
Tematy:
breast cancer in young patient
metastatic disease
non-pegylated liposomal doxorubicin
ribociclib
Opis:
The paper describes the case of a 31-year-old female patient with breast cancer with the abdominal metastases. This disease in young people usually has a more aggressive biological subtype, which significantly worsens the prognosis. In this patient aggressive treatment was used. It was effective and did not cause severe or long-term complications.
Źródło:
OncoReview; 2019, 9, 2; 51-54
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Breast cancer and factors affecting survival rate. Narrative review article
Autorzy:
Elzohry, Alaa Ali M.
Fikry, Engy Mohamed
Elhamed, Mohammed Farghaly Abd
Powiązania:
https://bibliotekanauki.pl/articles/1065175.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Breast cancer
Estrogen receptor ER
Progesterone receptor (PR)
Opis:
Breast cancer is the most common malignancy in women and it was estimated as the fifth cause of death from malignancy in the world. The objective of this review is to illustrate the incidence of cancer breast and demonstrate different factors affecting survival rate.
Źródło:
World Scientific News; 2019, 120, 2; 275-281
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative study on the classification methods for breast cancer diagnosis
Autorzy:
Qiu, Y.
Zhou, G.
Zhao, Q.
Cichocki, A.
Powiązania:
https://bibliotekanauki.pl/articles/200743.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
breast cancer
mammography
DDSM
comparative study
deep learning
rak piersi
mammografia
Badanie porównawcze
uczenie głębokie
Opis:
Digital mammography is one of the most widely used approaches for breast cancer diagnosis. Many researchers have demonstrated the superiority of machine learning methods in breast cancer diagnosis using different mammography databases. Since these methods often have different pros and cons, which may confuse doctors and researchers, an elaborate comparison and examination among them is urgently needed for practical breast cancer diagnosis. In this study, we conducted a comprehensive comparative study of the state-of-the-art machine learning methods that are promising in breast cancer diagnosis. For this purpose we analyze the largest mammography diagnosis database: Digital Database for Screening Mammography (DDSM). We considered various approaches for feature extraction including principal component analysis (PCA), nonnegative matrix factorization (NMF), spatial-temporal discriminant analysis (STDA) and those for classification including linear discriminant analysis (LDA), random forests (RaF), k-nearest neighbors (kNN), as well as deep learning methods including convolutional neural networks (CNN) and stacked sparse autoencoder (SSAE). This paper can serve as a guideline and useful clues for doctors who are going to select machine learning methods for their breast cancer computer-aided diagnosis (CAD) systems as well for researchers interested in developing more reliable and efficient methods for breast cancer diagnosis.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2018, 66, 6; 841-848
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stres oksydacyjny w raku piersi
Oxidative stress in breast cancer
Autorzy:
Kędzierska, Magdalena
Olas, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1194693.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Opis:
Stres oksydacyjny definiowany jest jako zachwianie równowagi pomiędzy powstawaniem (nadprodukcją) wolnych rodników, a zdolnościami indywidualnych mechanizmów obronnych. Produkcja wolnych rodników jest stałym elementem metabolizmu tlenowego komórki. Jest powszechnie wiadomo, że stres oksydacyjny wywołuje wiele stanów patologicznych i chorób. Stres oksydacyjny jest przyczyną uszkodzeń wielu ważnych makromolekuł, do których zaliczamy: DNA, białka i lipidy. Wzrost poziomu wolnych rodników wpływa też na transformację nowotworową komórki. Procesowi formowania i rozwojowi nowotworu towarzyszy zachwianie równowagi redox w komórce, nadprodukcja reaktywnych form tlenu i azotu. Obecnie rak piersi jest najczęstszym nowotworem złośliwym u kobiet w Polsce i na świecie. Biologia tego nowotworu i jego kliniczny obraz jest bardzo heterogenny. Stres oksydacyjny i zmiany oksydacyjno-nitracyjne są często obserwowane u chorych z rakiem piersi, ale nadal mechanizmy relacji między stresem oksydacyjnym czy nitracyjnym a rakiem piersi są niejasne. Stres oksydacyjny i nitracyjny obserwowany u pacjentów chorych na raka piersi może również indukować zmiany strukturalne i zmiany funkcji różnych elementów układu hemostazy. Organizm człowieka wyposażony jest w kilka sposobów ochrony przed atakiem oksydacyjnym. Mechanizmy obrony obejmują różne enzymy antyoksydacyjne, do których zaliczamy: peroksydazę glutationową, katalazę, dysmutazę ponadtlenkową i inne substancje, takie jak niskocząsteczkowe tiole: glutation, cysteinę, witaminę E, C i A, które eliminują wolne rodniki. Jest to bardzo istotne szczególnie dla chorych z rakiem piersi podczas chemioterapii wielolekowej, czy przed- lub pooperacyjnej radioterapii.
Oxidative stress may be defined as an imbalance between reactive oxygen species and the individual antioxidant defense system. Reactive oxygen species formation is a constant element of a cell's oxygen metabolism. It is now known that oxidative stress is involved in most of pathological states and diseases. Oxidative stress causes damage to important macromolecules, such as DNA, proteins, and lipids. Growing evidence indicates the participation of free radicals in the cancerous transformation of cells. The process of cancer formation and development is associated with loss of redox balance in the cell and with overproduction of reactive oxygen and nitrogen species. Actually breast cancer is the most common malignant neoplasm in women both in Poland and worldwide. It is biologically and clinically very heterogenous disease. Oxidative stress and oxidative-nitrative changes in the cells are frequently observed in breast cancer patients, but until now mechanisms involved in the relationship between oxidative stress and breast cancer are still unclear. Oxidative stress species may also induce changes to the structure and function in hemostatic elements. Human organisms have developed several ways to protect themselves from oxidant attacks. The defense mechanisms include a variety of antioxidant enzymes like glutathione peroxidase, catalase and superoxide dismutase and other substances such as low-molecular-weight thiols, such as glutathione, cysteine and vitamins E, C and A, which provide to eliminate free radicals are very important for the development of breast cancer and during multichemotherapy with different anti-cancer drugs or pre- and postoperative radiation therapy.
Źródło:
Kosmos; 2012, 61, 4; 547-555
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dietary practices and nutritional status in survivors of breast cancer
Autorzy:
Kaledkiewicz, E.
Szostak-Wegierek, D.
Powiązania:
https://bibliotekanauki.pl/articles/874275.pdf
Data publikacji:
2018
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Opis:
Background. Wrong dietary practices and excessive body mass may not only influence the risk of primary breast cancer but also the risk of its recurrence. Objective. Evaluation of dietary practices and identification of nutritional factors which may influence the risk of tumor recurrence in women with prior breast cancer. Materials and methods. The case-control study involved 108 women aged 50 years and older with history of breast cancer who were divided into two categories: women after completed cancer treatment with no recurrence for minimum 5 years (group I, n=82) and women with diagnosed breast cancer recurrence (group II, n=26). A control group (n=74) constituted of subjects with no breast cancer diagnosis. In every subject anthropometric measurements were taken and dietary practices were evaluated by means of an original questionnaire. Results. Average BMI and hip circumference values were higher in the group II than in the group I. In both study groups the percentage of high WHR values was significantly higher than in the control group. Women with history of cancer consumed significantly fewer vegetable and fruit and more refined cereals, dairy products, meat and cold cuts than women in the control group. Group I responders more often declared implementation and maintenance of changes in their diet after diagnosis of cancer than women from group II. Subjects with cancer history consumed more alcohol and more often used supplements than females in the control group. Conclusion. Avoiding overweight and obesity along with following the principles of a healthy diet seems to reduce the risk of both breast cancer incidence and its recurrence.
Wprowadzenie. Sposób żywienia i nadmierna masa ciała mogą wpływać nie tylko na powstawanie raka piersi lecz również na ryzyko wystąpienia nawrotów choroby. Cel. Ocena sposobu żywienia oraz identyfikacja czynników żywieniowych mogących mieć wpływ na ryzyko nowotworu u kobiet po przebytym raku piersi. Materiał i metody. Badanie kliniczno-kontrolne objęło 108 kobiet po 50. roku życia z rakiem piersi na podstawie wywiadu. Kobiety zostały podzielone na dwie grupy: grupa I, (n=82) - kobiety po zakończonym leczeniu, u których przez minimum 5 lat nie wystąpiło wznowienie choroby i grupa II, (n=26) - kobiety z wtórnie zdiagnozowanym rakiem piersi. Grupę kontrolną (n=74) stanowiły kobiety bez raka piersi w wywiadzie. Wykonano badania antropometryczne oraz przeanalizowano sposób żywienia kobiet przy użyciu autorskiego kwestionariusza. Wyniki. W grupie II kobiet zaobserwowano wyższe średnie wartości BMI oraz obwodu bioder niż w grupie I. W obu grupach badanych odsetek wysokich wartości WHR był istotnie wyższy niż w grupie kontrolnej. Kobiety z historią nowotworową spożywały istotnie mniej warzyw i owoców oraz więcej nabiału, mięs i wędlin niż kobiety z grupy kontrolnej. Respondentki z grupy I istotnie częściej deklarowały wprowadzenie i utrzymanie zmian w sposobie żywienia po rozpoznaniu choroby niż kobiety z grupy II. Kobiety z historią nowotworową wypijały większe ilości alkoholu i częściej stosowały suplementy diety niż kobiety onkologicznie zdrowe. Wnioski. Unikanie nadwagi i otyłości oraz przestrzeganie zasad zdrowej diety wydaje się zmniejszać ryzyko zarówno zachorowania na raka piersi jak i wystąpienia jego nawrotów.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2018, 69, 2
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Breast cancer imaging by means of optoacoustic technique: initial experience
Autorzy:
Andreev, V. G.
Oraevsky, A. A.
Karabutov, A. A.
Powiązania:
https://bibliotekanauki.pl/articles/332227.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Akustyczne
Opis:
A clinical prototype of the laser optoacoustic imaging system (LOIS) for breast cancer detection with 32-element transducer array is described. The frequency band of transducer array provided 0.5-mm axial in-depth resolution. Cylindrical shape of the 10-cm long array enabled us to receive the lateral resolution of 1.0 mm in the vicinity of focal zone. The system sensitivity provided detection of a 2-mm absorbing sphere at the depth of 60mm. An automatic recognition of the optoacoustic signal detected from the irradiated surface was implemented in order to visualize the breast surface and improve the accuracy of tumor localization. Radial back-projection algorithm was used for image reconstruction. Optimal filtering of image was employed to reduce low and high frequency noise. Time necessary for data acquisition and image reconstruction was reduced to 32 sec. The system performance was evaluated initially by imaging of the small absorbing objects in breast tissue-like phantoms. Clinical ex-vivo studies of mastectomy specimens were performed and compared with X-ray radiography and ultrasound.
Źródło:
Hydroacoustics; 2001, 4; 1-4
1642-1817
Pojawia się w:
Hydroacoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ascites as the first sign of breast cancer – case report
Autorzy:
Niedzialek, J.
Kicinski, P.
Przybylska-Kuc, S.
Prystupa, A.
Krzyzanowski, K.
Dzida, G.
Mosiewicz, J.
Jaroszynski, A.
Powiązania:
https://bibliotekanauki.pl/articles/3674.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Źródło:
Journal of Pre-Clinical and Clinical Research; 2012, 06, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Triple negative breast cancer with ACTH-dependent Cushings syndrome - case report
Autorzy:
Hodorowicz-Zaniewska, Diana
Brzuszkiewicz, Karolina
Szpor, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1392214.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
breast cancer
paraneoplastic syndrome
ACTH
adrenocorticotropin
Cushing’s syndrome
Opis:
Introduction: Endocrine and metabolic paraneoplastic syndromes in the course of malignant tumors result from ectopic production of hormones or hormone precursors in tumor cells. Production of hormones by endocrine tumors is relatively frequent, while such production by adenocarcinoma cells is definitely rare. The study presents a case of triple-negative invasive breast cancer, with the ectopic secretion of ACTH (adrenocorticotropic hormone), which provokes serious metabolic disorders. Materials and methods: The patient was admitted to hospital with symptoms of Cushing`s syndrome. Diagnostic tests revealed that the cause of metabolic disorders was breast cancer. After proper preparation, the patient was qualified for surgery. Results: After the mastectomy, the patient’s metabolism stabilized. The patient underwent adjuvant chemotherapy and radiotherapy. Four months after the last cycle of systemic treatment, cancer dissemination was found. The patient was treated with second-line chemotherapy, however, control CT revealed progression. The patient died 20 months after surgery and two months after the last cycle of chemotherapy. Conclusions: The case reported in this study – triple-negative invasive breast cancer, responsible for ectopic production of ACTH and causing Cushing’s syndrome – is a rare phenomenon. Treatment of patients with breast cancer showing hormonal activity should not differ from general rules applied for breast cancer. However, due to accompanying metabolic disturbances, the patients need individualized oncological approach, precise diagnostic tests, and adequate preoperative preparation.
Źródło:
Polish Journal of Surgery; 2019, 91, 2; 45-47
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rys historyczny leczenia raka piersi
Historic perspective of breast cancer treatment
Autorzy:
Pietrzyńska, Tatiana
Podwińska, Ewa
Olejek, Anita
Turek, Sebastian
Mazur, Jakub
Powiązania:
https://bibliotekanauki.pl/articles/908438.pdf
Data publikacji:
2007
Wydawca:
Medical Communications
Tematy:
breast cancer
chemotherapy
history
hormone therapy
radiotherapy
surgical techniques
treatment
Opis:
The authors took interest in historical aspects of treatment of breast cancer over past centuries. The first mentions of breast tumours or lumps appeared in Egyptian writings 3 thousand years ago. Etymology of the word “cancer” was explained by Paul of Egina by the resemblance of blood-engorged veins adjacent to breast tumour to crab legs. Ancient doctors not only diagnosed this disease, but also made attempts at treating it. Roman doctors considered breast cancer as a local disease and treated it by radical excision, including pectoral muscle. Greek doctor, Galen, was the first to consider breast cancer as a systemic disease and tried to treat it conservatively using herbal extracts of mandrake and cabbage. Cessation of progress of medicine characteristic for the Middle Ages resulted in a dramatic reduction in the scope of surgical techniques available. A renewed interest in science, including a return to Galen’s theory and ancient surgical techniques, took place in the Renaissance. At this time, European surgeons – Ambroise Paré, Wilhelm Fabry, Jacques Guillemen and others – made ever bolder attempts at surgical treatment of breast tumour. The XVIII century witnessed further progress of medical science, while the work by William and John Hunter enabled a better understanding of structure and principles of function of the lymphatic system. The XIX century is marked by tremendous progress in surgery, including surgical treatment of malignant tumours. Introduction of ether anaesthesia in 1846 by William T. Morton, paved the way for implementation of general anaesthesia in clinical practice. Subsequent achievements of this epoch were: understanding of aseptic and antiseptic principles and examination of tissues using a microscope. The XIX century was also marked by a search of non-surgical modalities of treatment of malignant breast tumours. In 1895 Emile Grubbe was the first to use radiotherapy after mastectomy. The XX century witnessed a tremendous progress of all hitherto available diagnostic and therapeutic techniques used in the management of patients with breast cancer, particularly those based on molecular biology and gene therapy.
Autorów pracy zainteresowała historia leczenia raka piersi. Pierwsze wzmianki o występowaniu guzów piersi pojawiły się w piśmiennictwie egipskim przed trzema tysiącami lat. Etymologię określenia „rak” opisywał Paweł z Eginy, wyjaśniając, że żyły wokół guza są wypełnione i napięte niczym odnóża kraba. Lekarze epoki starożytnej nie tylko rozpoznawali tę chorobę, ale też podejmowali próby jej leczenia. Medycy rzymscy uważali, że rak piersi jest chorobą miejscową, a w leczeniu jej stosowano radykalne wycięcie guza wraz z mięśniem piersiowym. Galen, lekarz grecki, traktował raka piersi jako chorobę uogólnioną i podejmował próby leczenia zachowawczego za pomocą wyciągów ziołowych z mandragory i kapusty. Średniowiecze charakteryzowało się zahamowaniem rozwoju medycyny, co skutkowało drastycznym ograniczeniem metod leczenia chirurgicznego. Ponowny rozkwit nauk przyrodniczych, w tym także powrót do teorii Galena i technik chirurgicznych, nastąpił dopiero w epoce renesansu. W tym czasie europejscy chirurdzy - Ambroise Pare, Wilhelm Fabry, Jacques Guillemen i inni - coraz odważniej podejmowali próby operacyjnego leczenia guzów piersi. Wiek XVIII przyniósł dalszy rozwój wiedzy medycznej, a dzięki pracom Williama i Johna Hunterów poznano budowę i zasady funkcjonowania układu limfatycznego. Wiek XIX charakteryzował się szczególnymi dokonaniami w zakresie rozwoju chirurgii, w tym także guzów nowotworowych. Dzięki zastosowaniu po raz pierwszy w 1846 roku przez Williama T. Mortona anestezji eterowej wdrożono do praktyki klinicznej metody znieczulania ogólnego. Kolejnymi osiągnięciami tej epoki było poznanie zasad aseptyki i antyseptyki oraz nabycie umiejętności oceny tkanek z użyciem mikroskopu. W XIX wieku poszukiwano również innych, poza chirurgicznymi, metod leczenia złośliwych guzów piersi. W 1895 roku Emile Grubbe zastosował pierwszą radioterapię po mastektomii. Wiek XX przyniósł doskonalenie wszystkich dotychczas stosowanych metod diagnostyki i leczenia raka piersi, ze szczególnym uwzględnieniem biologii molekularnej i terapii genowej.
Źródło:
Ginekologia Onkologiczna; 2007, 5, 4; 208-217
1731-5379
Pojawia się w:
Ginekologia Onkologiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Quality of life during the first year after breast cancer resection
Autorzy:
Kulesza-Bronczyk, B.
Dobrzycka, B.
Piekut, K.
Terlikowski, R.
Mackowiak-Matejczyk, B.
Wojno, A.
Terlikowski, SJ.
Powiązania:
https://bibliotekanauki.pl/articles/1916396.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Breast cancer
quality of life
questionnaires
Opis:
Introduction: Quality of life can be determined by a number of factors, including subjective perception of various spheres of health and health-unrelated factors. Purpose: To compare the quality of life of women who had breast cancer one month and one year after mastectomy, and to verify the usefulness of health-related quality of life (HRQoL) scales in early identification of patients having problems in various functional spheres. Materials and methods: The study included the group of 110 mastectomized women. Quality of life of the participants was estimated with EORTC QLQ-C30 and EORTC QLQ-BR23 questionnaires. Results: Global health status (QoL) determined with the aid of the EORTC QLQ-C30 questionnaire turned out to be significantly higher in women surveyed one year after mastectomy than in those examined one month after the surgery (74.23 vs. 58.33, p<0.001). Moreover, the two groups of patients differed significantly in terms of physical, cognitive, social and role functioning scores. Most of the symptoms assessed were resolved within a year after the breast cancer surgery. No significant intergroup differences were revealed with regard to emotional and socioeconomic functioning or future perspective scores. Conclusions: Quality of life of most mastectomized women improves considerably within one year after the surgery. The use of quality of life instruments can be useful in early postoperative identification of patients who score low on functional and symptom scales. Such patients require support and/or psycho-oncological treatment during the early postoperative period. Quality of life of breast cancer patients during the early postoperative period can be a predictor of this parameter in a longer-term perspective.
Źródło:
Progress in Health Sciences; 2014, 4, 1; 124-129
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Complex Dielectric Coefficient of Breast Phantom Prepared for Breast Cancer Detection
Autorzy:
Sayinti, A.
Açikalin, E.
Çoban, K.
Vertii, A.
Powiązania:
https://bibliotekanauki.pl/articles/1400036.pdf
Data publikacji:
2013-02
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
77.22.Ch
Opis:
Microwave measurement techniques attract attention due to its practical solutions in breast cancer imaging. Early detection of cancer is the purpose of these imaging studies. For these imaging processes, phantoms which reflect the properties of the area to be imaged are produced. The produced homogeneous phantoms are imaged by stepper frequency of radar technology, as the narrow bands are used for heterogeneous mixtures. Phantoms are used since 70's until today. Different methods are experimented for producing phantoms of tissue, muscle, fat, skin, etc. Iron powder, polymer materials, various oils and gelatins used today are the materials used for producing the phantoms. In this study, phantom breast imaging is aimed. Phantoms breast and breast tumor samples are created. For phantoms and tumor samples, reflection and transmittion measurements are done with Network Analyzer in X-Band (8.2-12.4 GHz). Complex permittivity is calculated with Agilent 85071 Material Measurement Software-Fast Method (NIST-iterative method). It was considered breast phantom with tumor model for 3D imagine at 2-3.5 GHz frequency range.
Źródło:
Acta Physica Polonica A; 2013, 123, 2; 464-466
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reduced expression of AURKA in peripheral blood of breast cancer patients
Autorzy:
Goh, L.P.W.
See, E.U.H.
Chua, K.H.
Lee, P.-C.
Powiązania:
https://bibliotekanauki.pl/articles/81279.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
breast cancer
patient
Aurora kinase
gene expression
peripheral blood
cell cycle
quantitative real-time polymerase chain reaction
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2018, 99, 1
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rola eksemestanu w leczeniu raka piersi
Exemestan in breast cancer treatment
Autorzy:
Wójcik, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/1067895.pdf
Data publikacji:
2012
Wydawca:
Medical Education
Tematy:
eksemestan
hormonoterapia
inhibitory aromatazy
rak piersi
Opis:
Hormonotherapy is one of the most important therapeutic options in the breast cancer treatment, either locally advanced or metastatic. Tamoxifen has been standard of care for many years, however new clinical trials results indicates aromatase inhibitors as a valuable alternative for postmenopausal patients. Exemestane is a steroid aromatase inhibitor with effectiveness proven in clinical trials discussed in this article.
Leczenie hormonalne jest jedną z podstawowych opcji terapeutycznych w leczeniu raka piersi, zarówno miejscowo zaawansowanego, jak i przerzutowego. Standardem od wielu lat pozostaje tamoksyfen, jednak wyniki nowych badań klinicznych wskazują na inhibitory aromatazy jako na wartościową alternatywę w terapii pacjentek po menopauzie. Eksemestan jest steroidowym inhibitorem aromatazy, którego skuteczność została udowodniona na podstawie wyników badań omówionych w poniższym artykule.
Źródło:
OncoReview; 2012, 2, 4; 264-268
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Breast cancer cad system by using transfer learning and enhanced ROI
Autorzy:
Al-Huseiny, Muayed S
Sajit, Ahmed S
Powiązania:
https://bibliotekanauki.pl/articles/2097433.pdf
Data publikacji:
2022
Wydawca:
Polskie Towarzystwo Promocji Wiedzy
Tematy:
mammography
transfer learning
computer vision
image processing
Opis:
Computer systems are being employed in specialized professions such as medical diagnosis to alleviate some of the costs and to improve dependability and scalability. This paper implements a computer aided breast cancer diagnosis system. It utilizes the publicly available mini MIAS mammography image dataset. Images are preprocessed to clean isolate breast tissue region. Extracted regions are used to adjust and verify a pretrained convolutional deep neural network, the GoogLeNet. The implemented model shows good performance results compared to other published works with accuracy of 86.6%, sensitivity of 75% and specificity of 88.9%.
Źródło:
Applied Computer Science; 2022, 18, 1; 99--111
1895-3735
Pojawia się w:
Applied Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Altered tissue electrical properties in women with breast cancer – Preliminary observations.
Autorzy:
Malecka-Massalska, T.
Chara, K.
Golebiowski, P.
Wladysiuk, M.
Smolen, A.
Kurylcio, A.
Zuchora, B.
Zubrzycki, J.
Orlowska-Kowalik, G.
Lupa-Zatwarnicka, K.
Polkowski, W.
Powiązania:
https://bibliotekanauki.pl/articles/51083.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Opis:
Introduction and objectives: In the United States, breast cancer (BC) is the most common non-skin cancer. In Poland, it is estimated that the number of new breast cancer cases affects about 13,500 women each year. There are many methods for nutritional status assessment. One of them is bioimpedance analysis (BIA). Direct bioimpedance measures (resistance, reactance, phase angle (PA)) determined by bioelectrical impedance analysis (BIA) detectf changes in tissue electrical properties. The study was conducted to investigate whether there are any tissue electrical differences in patients with breast cancer. Materials and methods: The direct bioimpedance measures determined by bioelectrical impedance analysis (BIA) were performed on 34 patients with BC and 34 healthy volunteers. The measurements were made with ImpediMed bioimpedance analysis SFB7 BioImp v1.55 (Pinkenba Qld 4008, Australia). Results: Reactance and resistance at 50 kHz was found to be significantly greater in patients with BC than in the control group (53.59° ± 1.53 vs. 47.26° ± 1.25, respectively, p=0.0031; 603.24° ± 15.38 ohm vs. 515.87° ± 11.48 ohm, respectively, p=0.00004). Conclusion: Pre-surgical patients diagnosed with BC have altered tissue electrical properties. Further observations of a larger patient group would be valuable to calculate survival, validate the prognostic significance of PA, and monitor nutritional and therapeutic interventions in this patient population.
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Szczególne postacie kliniczne nowotworów złośliwych piersi
Rare clinical types of breast cancer
Autorzy:
Piekarski, Janusz H.
Powiązania:
https://bibliotekanauki.pl/articles/1031204.pdf
Data publikacji:
2012
Wydawca:
Medical Communications
Tematy:
paget’s disease of the nipple
bilateral breast cancer
isolated metastases of other tumors to the breast
occult breast cancer
breast cancer in the elderly
choroba pageta brodawki sutkowej
obustronny rak piersi
izolowane przerzuty innych nowotworów do piersi
ukryty rak piersi
rak piersi u chorych w podeszłym wieku
Opis:
Paget’s disease of the nipple may exist as an isolated condition or may be associated with breast cancer. Paget’s disease-associated breast cancer may be intraductal or invasive; depending on location, it may be retromamillary or peripheral. Surgical treatment consists in sparing procedure or breast amputation. Patients with Paget’s disease coexisting with an infiltrating breast cancer, should undergo sentinel node biopsy or axillary lymphadenectomy. Bilateral breast cancer is diagnosed in women diagnosed with primary cancer in both breasts. This definition does not include metastases of unilateral breast cancer to contralateral breast. Recommended type of surgical treatment is bilateral mastectomy and bilateral biopsy of sentinel node or axillary lymphadenectomy. Sparing treatment is a therapeutic option applicable in reference centers only. Isolated metastases of other tumors to the breasts are very rare. The usual origin of breast metastases is contralateral breast cancer. Less frequent are secondary foci of lymphoma and melanoma. Management strategy depends on what type of malignant tumor was the source of metastases. The cornerstone of treatment is usually systemic treatment, if available. Surgical treatment is limited to surgical biopsy or palliative treatment (e.g. mastectomy due to bleeding from the tumor). Occult breast cancer is diagnosed in women with metastases of adenomatous cancer, non-differentiated or non-classified to axillary lymph nodes, when neither physical nor radiological examination reveal a primary breast cancer. The most probable origin of axillary metastases is breast cancer. Surgical treatment consists in axillary lymphadenectomy and mastectomy. One may withhold from mastectomy if spared breast will undergo total radiotherapy. Breast cancer in the elderly, i.e. persons over 70, accounts for over 30% of all breast cancer cases. Surgical treatment of elderly women with breast cancer should be based on standard protocols (mastectomy or sparing treatment; biopsy of sentinel node and/or axillary lymphadenectomy). Standard treatment protocol can and should be modified when treatment-associated risk exceeds expected benefits thereof.
Choroba Pageta brodawki sutkowej występuje w postaci izolowanej lub może jej towarzyszyć rak piersi. Rak piersi towarzyszący chorobie Pageta brodawki sutkowej to rak in situ lub rak naciekający; może być umiejscowiony zabrodawkowo lub obwodowo. Leczenie chirurgiczne polega na wykonaniu zabiegu oszczędzającego lub amputacji piersi. U chorych, u których chorobie Pageta brodawki sutkowej towarzyszy naciekający rak piersi, należy ponadto wykonać biopsję węzła wartowniczego i/lub limfadenektomię pachową. Obustronnego raka piersi rozpoznaje się u kobiet, u których stwierdzono dwa pierwotne raki w obu piersiach. Definicja ta nie obejmuje przerzutów jednostronnego raka piersi do drugiej piersi. Zalecanym sposobem leczenia chirurgicznego jest wykonanie obustronnej amputacji piersi oraz obustronnie biopsji węzła wartowniczego i/lub limfadenektomii pachowej. Leczenie oszczędzające jest opcją terapeutyczną możliwą do zastosowania w ośrodkach referencyjnych. Izolowane przerzuty innych nowotworów do piersi występują bardzo rzadko. Najczęściej źródłem przerzutów do piersi jest rak drugiej piersi. W dalszej kolejności w piersi stwierdza się wtórne ogniska nowotworów układu chłonnego i przerzuty czerniaka. Sposób leczenia zależy od tego, jaki nowotwór złośliwy był źródłem przerzutu. Podstawą leczenia jest zazwyczaj leczenie systemowe, jeżeli jest ono dostępne. Leczenie chirurgiczne ogranicza się do wykonywania biopsji chirurgicznej lub do zabiegów paliatywnych (np. mastektomii z powodu krwawień z guza). Ukrytego raka piersi rozpoznaje się u kobiet, u których występują przerzuty raka gruczołowego, niezróżnicowanego lub niesklasyfikowanego w pachowych węzłach chłonnych, natomiast przeprowadzone badanie przedmiotowe i badania radiologiczne nie ujawniły obecności pierwotnego raka w piersi. Najbardziej prawdopodobnym źródłem przerzutów w pasze jest rak piersi. Leczenie chirurgiczne polega na wykonaniu limfadenektomii pachowej oraz amputacji piersi. Można odstąpić od wykonania amputacji piersi jeżeli oszczędzona pierś zostanie poddana radykalnej radioterapii. Rak piersi u chorych w podeszłym wieku, czyli po 70. roku życia, stanowi ponad 30% wszystkich raków piersi. Leczenie chirurgiczne kobiet w wieku podeszłym chorych na raka piersi powinno opierać się na zasadach standardowych (amputacja piersi lub leczenie oszczędzające; biopsja węzła wartowniczego i/lub limfadenektomia pachowa). Standardowy plan leczenia może zostać zmodyfikowany i powinien, jeżeli ryzyko związane z leczeniem przewyższa korzyści, jakie to leczenie może przynieść.
Źródło:
Current Gynecologic Oncology; 2012, 10, 4; 326-336
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Imaging methods of early detection and screening for breast cancer. A review
Autorzy:
Gustalik, Joanna
Bartusik-Aebisher, Dorota
Aebisher, David
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454888.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
breast cancer
breast MRI
early detection
screening
Opis:
Introduction. Breast cancer is the most frequent neoplasm among women. That is the reason why scientists all over the world are attempting to improve early detection methods of this particular malignancy. Aim. The most common and most widely used examination methods for screening for and detecting breast cancer is presented herein. Material and methods. This review was performed according to systematic literature search of three major bibliographic databases. Results. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. Conclusion. The role of a physician is to select the most suitable one for each patient in order to obtain the best result. No matter the method however, between 2005 and 2011, the 5-year relative survival was found to be 89%. This is thought to be due to both the increase in utilization of population-wide screening, as well as advances in treatment.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 142-145
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Computer-aided diagnosis of breast cancer using gaussian mixture cytological image segmentation
Autorzy:
Kowal, M.
Filipczuk, P.
Obuchowicz, A.
Korbicz, J.
Powiązania:
https://bibliotekanauki.pl/articles/333385.pdf
Data publikacji:
2011
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
segmentacja obrazu
klasyfikacja
rak piersi
image segmentation
classification
breast cancer
Opis:
This paper presents an automatic computer system to breast cancer diagnosis. System was designed to distinguish benign from malignant tumors based on fine needle biopsy microscope images. Studies conducted focus on two different problems, the first concern the extraction of morphometric and colorimetric parameters of nuclei from cytological images and the other concentrate on breast cancer classification. In order to extract the nuclei features, segmentation procedure that integrates results of adaptive thresholding and Gaussian mixture clustering was implemented. Next, tumors were classified using four different classification methods: k–nearest neighbors, naive Bayes, decision trees and classifiers ensemble. Diagnostic accuracy obtained for conducted experiments varies according to different classification methods and fluctuates up to 98% for quasi optimal subset of features. All computational experiments were carried out using microscope images collected from 25 benign and 25 malignant lesions cases.
Źródło:
Journal of Medical Informatics & Technologies; 2011, 17; 257-262
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
RT-PCR Analysis of TopBP1 Gene Expression in Hereditary Breast Cancer
Autorzy:
Forma, Ewa
Bernaciak, Magdalena
Romanowicz-Makowska, Hanna
Bryś, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/764886.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
TopBP1
gene expression
RT-PCR
hereditary breast cancer
Opis:
Hereditary predisposition to breast cancer determined in large part by loss of function mutations in one of two genes BRCA1 and BRCA2. Besides BRCA1 and BRCA2 other genes are also likely to be involved in hereditary predisposition to breast cancer. TopBP1 protein is involved in DNA replication, DNA damage checkpoint response and transcriptional regulation. Expression of TopBP1 gene at the mRNA level was analyzed by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) in 94 samples of hereditary breast cancer. Analysis of TopBP1 mRNA level showed that expression of TopBP1 is significantly downregulated in poorly differentiated breast cancer (grade III according Bloom-Richardson system (P<0.05).
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2010, 6; 49-59
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Health behaviors of patients after breast cancer surgery in the Podkarpackie voivodeship
Autorzy:
Pusz-Sapa, Aleksandra
Gaweł, Greta
Sobczyk, Joanna
Wojtasik, Aneta
Król, Małgorzata
Misiewicz, Emilia
Lidwin, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/454741.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
breast cancer
health behaviors
diet
physical activity
Opis:
Aim. An evaluation of lifestyle changes (physical activity, diet) in patients after breast cancer surgery. Materials and method. 200 women after breast cancer surgery were surveyed. The respondents were asked whether the surgery caused a change in their diet and physical activity. An analysis was performed concerning the education, place of residence and age of the respondents. Results. Prior to being diagnosed with breast cancer, about one third of the respondents were concerned about their diet and physical activity. After the surgery more than a half of the respondents were concerned about a healthy lifestyle. Women below 50 years old with higher education, who live in a city, were concerned about their diet and physical activity both before and after surgery. Conclusions. As a result of the breast cancer surgery, lifestyle changes were most often found in women aged 50-69 years old with higher education who lived in a city. Statistical relevance of the results was noted.
Źródło:
European Journal of Clinical and Experimental Medicine; 2017, 4; 310-314
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Palliative care in advanced breast cancer
Opieka paliatywna w zaawansowanym raku piersi
Autorzy:
Pietrzyńska, Tatiana
Podwińska, Ewa
Olejek, Anita
Zamłyński, Jacek
Turek, Sebastian
Powiązania:
https://bibliotekanauki.pl/articles/908517.pdf
Data publikacji:
2009
Wydawca:
Medical Communications
Tematy:
advanced breast cancer
oncologic treatment
palliative care
quality of life
Opis:
Breast cancer is currently one of the most frequent malignant neoplasms in Polish women. Since the ‘80s of past century, breast cancer is the leading cause of mortality in women aged 40-59. Patients are usually admitted to the stationary palliative care facilities in a far advanced stage of neoplastic disease originating primarily in the breast and are mostly in a poor general condition. Their overall condition is a resultant of development and severity of the tumour itself with possible distant metastases, coexisting diseases, as well as late complications of cause-oriented or palliative treatment implemented. In the setting of palliative treatment, the primary goal is relief of pain, according to the recommendations of the so-called “analgetic ladder”, conforming with general principles of analgetic management. This consists in determination of cause of pain, evaluation of its type and severity, regular pace of administration of analgetic drugs, careful titration of dose of strong analgetics, oral administration of drugs, as this is the most physiologic and recommended route of administration, if only the patient can tolerate it. An important issue is also to relieve other bothersome ailments, both somatic, mental, spiritual and social. According to the WHO definition, palliative care ensures the patients a comprehensive and active care, improves their quality of life and, when justified, includes all oncologic therapeutic modalities. In the setting of palliative care, oncologic treatment aims at arresting or slowing-down of development of primary tumour and metastatic foci, thus improving the patient’s comfort and quality of life, obviously taking into account current state of the patient and toxicity of drugs.
Rak piersi należy obecnie do najczęstszych nowotworów złośliwych u kobiet w Polsce. Począwszy od lat 80. ubiegłego wieku rak piersi stanowi pierwszą co do częstości przyczynę zgonów kobiet w wieku między 40. a 59. rokiem życia. Chore przyjmowane na stacjonarny oddział opieki paliatywnej w zaawansowanym stadium choroby nowotworowej wywodzącej się pierwotnie z obszaru piersi są zazwyczaj w złym stanie ogólnym. Jest to spowodowane rozwojem i nasileniem objawów choroby, z możliwością występowania przerzutów do odległych narządów, a także chorobami współistniejącymi, jak również powikłaniami późnymi po stosowanym leczeniu przyczynowym lub paliatywnym. W oddziale opieki paliatywnej stosuje się w pierwszej kolejności leczenie przeciwbólowe, zgodnie z zaleceniami drabiny analgetycznej oraz uwzględnieniem głównych zasad postępowania przeciwbólowego. Leczenie to polega na ustaleniu przyczyny bólu, ocenie rodzaju i jego natężenia, regularności podawanego leku, miareczkowaniu dawki silnego analgetyku, podawaniu leków doustnie, gdyż jest to droga fizjologiczna i zalecana, o ile chory może w ten sposób przyjmować preparaty. Istotne jest także łagodzenie innych uciążliwych dolegliwości - zarówno somatycznych, psychicznych, duchowych, jak i socjalnych. Zgodnie z definicją Światowej Organizacji Zdrowia (WHO) w ramach opieki paliatywnej zapewnia się chorym całościową, czynną opiekę, poprawiającą ich jakość życia, a także stosuje w uzasadnionych przypadkach wszystkie onkologiczne metody leczenia. Terapia onkologiczna w ramach opieki paliatywnej ma na celu zahamowanie lub spowolnienie rozwoju guzów nowotworowych lub przerzutowych, a co za tym idzie poprawę komfortu i jakości życia chorego, oczywiście z uwzględnieniem jego aktualnego stanu i toksyczności ewentualnego leczenia.
Źródło:
Ginekologia Onkologiczna; 2009, 7, 2; 123-130
1731-5379
Pojawia się w:
Ginekologia Onkologiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Breast cancer nuclei segmentation and classification based on a deep learning approach
Autorzy:
Kowal, Marek
Skobel, Marcin
Gramacki, Artur
Korbicz, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1838197.pdf
Data publikacji:
2021
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
breast cancer
nuclei segmentation
image processing
nowotwór piersi
segmentacja jądra
przetwarzanie obrazu
Opis:
One of the most popular methods in the diagnosis of breast cancer is fine-needle biopsy without aspiration. Cell nuclei are the most important elements of cancer diagnostics based on cytological images. Therefore, the first step of successful classification of cytological images is effective automatic segmentation of cell nuclei. The aims of our study include (a) development of segmentation methods of cell nuclei based on deep learning techniques, (b) extraction of some morphometric, colorimetric and textural features of individual segmented nuclei, (c) based on the extracted features, construction of effective classifiers for detecting malignant or benign cases. The segmentation methods used in this paper are based on (a) fully convolutional neural networks and (b) the marker-controlled watershed algorithm. For the classification task, seven various classification methods are used. Cell nuclei segmentation achieves 90% accuracy for benign and 86% for malignant nuclei according to the F-score. The maximum accuracy of the classification reached 80.2% to 92.4%, depending on the type (malignant or benign) of cell nuclei. The classification of tumors based on cytological images is an extremely challenging task. However, the obtained results are promising, and it is possible to state that automatic diagnostic methods are competitive to manual ones.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2021, 31, 1; 85-106
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of genes modulated by epigallocatechin-3-gallate in breast cancer cells
Autorzy:
Bogacz, A.
Wolek, M.
Juskowiak, B.
Karasiewicz, M.
Kaminski, A.
Uzar, I.
Polaszewska, A.
Kostrzewa, Z.
Czerny, B.
Powiązania:
https://bibliotekanauki.pl/articles/72469.pdf
Data publikacji:
2018
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
gene expression
epigallocatechin-3-gallate
breast cancer
cancer cell
therapy
Opis:
Breast cancer is the most common malignant cancer among women. Both drug resistance and metastasis are major problems in the treatment of breast cancer. Therefore, adjuvant therapy may improve patients’ survival and affect their quality of life. It is suggested that epigallocatechin gallate (EGCG) which is well known for its chemopreventive activity and acts on numerous molecular targets may inhibit the growth and metastasis of some cancers. Hence, discovering the metastatic molecular mechanisms for breast cancer may be useful for therapy.The aim of the study was to determine the effect of EGGC on the mRNA expression level of genes such as ZEB1, ABCB1, MDM2, TWIST1 and PTEN in MCF-7 breast cancer cells. MCF7/DOX were cultured in the presence of 0.2 μM DOX and EGCG (20-50 μM). The mRNA expression level was determined by real-time quantitative PCR using RealTime ready Custom Panel 96 kit. Our results showed an important increase (about 2-fold for 20 μM EGCG + 0.2 μM DOX and 2.5-fold for 50 μM EGCG + 0.2 μM DOX, p<0.05) in ZEB1 expression levels. In case of ABCB1 gene lack of influence on the mRNA level was observed (p>0.05). We also observed significant decrease of ZEB1 expression in MCF7 cells with 20 μM and 50 μM EGCG (p<0.05). In addition, EGCG (20 μM) caused an increase of MDM2 and PTEN mRNA levels in almost 100% (p<0.05) and 40% (p>0.05), respectively. Lack of the influence of EGCG was noted for the TWIST1 gene expression. In case of MCF7/DOX we showed an increase of mRNA level of PTEN gene about 50% (p<0.05). These results suggest that EGCG may be potentially used in adjuvant therapy in the breast cancer treatment.
Źródło:
Herba Polonica; 2018, 64, 3
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
GLCM and GLRLM based texture features for computer-aided breast cancer diagnosis
Autorzy:
Filipczuk, P.
Fevens, T.
Krzyżak, A.
Obuchowicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/333264.pdf
Data publikacji:
2012
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
diagnostyka wspomagana komputerowo
analiza teksturalna
rak piersi
computer-aided diagnosis
texture features
breast cancer
Opis:
This paper presents 15 texture features based on GLCM (Gray-Level Co-occurrence Matrix) and GLRLM (Gray-Level Run-Length Matrix) to be used in an automatic computer system for breast cancer diagnosis. The task of the system is to distinguish benign from malignant tumors based on analysis of fine needle biopsy microscopic images. The features were tested whether they provide important diagnostic information. For this purpose the authors used a set of 550 real case medical images obtained from 50 patients of the Regional Hospital in Zielona Góra. The nuclei were isolated from other objects in the images using a hybrid segmentation method based on adaptive thresholding and kmeans clustering. Described texture features were then extracted and used in the classification procedure. Classification was performed using KNN classifier. Obtained results reaching 90% show that presented features are important and may significantly improve computer-aided breast cancer detection based on FNB images.
Źródło:
Journal of Medical Informatics & Technologies; 2012, 19; 109-115
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Breast cancer diagnosis using wrapper-based feature selection and artificial neural network
Autorzy:
Naveed, Nawazish
Madhloom, Hayan T.
Husain, Mohd Shahid
Powiązania:
https://bibliotekanauki.pl/articles/1956040.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Promocji Wiedzy
Tematy:
breast cancer diagnosis
feature selection
neural network
grid search
machine learning
diagnostyka raka piersi
dobór cech
sieć neuronowa
przeszukiwanie sieci
uczenie maszynowe
Opis:
Breast cancer is commonest type of cancers among women. Early diagnosis plays a significant role in reducing the fatality rate. The main objective of this study is to propose an efficient approach to classify breast cancer tumor into either benign or malignant based on digitized image of a fine needle aspirate (FNA) of a breast mass represented by the Wisconsin Breast Cancer Dataset. Two wrapper-based feature selection methods, namely, sequential forward selection(SFS) and sequential backward selection (SBS) are used to identify the most discriminant features which can contribute to improve the classification performance. The feed forward neural network (FFNN) is used as a classification algorithm. The learning algorithm hyper-parameters are optimized using the grid search process. After selecting the optimal classification model, the data is divided into training set and testing set and the performance was evaluated. The feature space is reduced from nine feature to seven and six features using SFS and SBS respectively. The highest classification accuracy recorded was 99.03% with FFNN using the seven SFS selected features. While accuracy recorded with the six SBS selected features was 98.54%. The obtained results indicate that the proposed approach is effective in terms of feature space reduction leading to better accuracy and efficient classification model.
Źródło:
Applied Computer Science; 2021, 17, 3; 19-30
1895-3735
Pojawia się w:
Applied Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of prognostic parameters of E-cadherin status in breast cancer treatment
Autorzy:
Brzozowska, A.
Sodolski, T.
Duma, D.
Mazurkiewicz, T.
Mazurkiewicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/49313.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Opis:
Introduction and objective. Breast cancer is one of the most frequent malignancies in women. Axillary lymph node involvement, tumour size, receptor status, and level of malignancy are the most significant prognostic factors in breast cancer, but insufficient to date. More factors are needed for establishing the prognosis and treatment in these patients. The aim of the presented study was evaluation of E- cadherin expression and its prognostic value among 89 specimens of breast cancer. Materials and methods. 89 formalin-fixed and paraffin-embedded breast cancer specimens were studied for expression of E-cadherin detected by immunohistochemistry. During 10-year observation overall/OS/and disease-free survival/DFS/ of patients were assessed. Results. Average of OS and DFS were shorter among patients without expression of E-cadherin in comparison to survival time of patients with expression of E-cadherin. The lack of E-cadherin expression was present more often among patients with distant metastasis. No essential changes were noticed in the level of E-cadherin depending on the size of the tumour, G, presence of metastasis into the lymph nodes, ER, PR and HER-2, hormonal condition and presence of cancerous tissues in lymphatic vessels and the infiltration of lymph nodes capsules.
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detection of circulating tumour cells in the breast cancer using CytoTrack system
Autorzy:
Bogacz, A.
Wolek, M.
Górska, A.
Leporowska, E.
Procyk, D.
Kolenda, P.
Litwiniuk, M.
Uzar, I.
Gryszczyńska, A.
Łowicki, Z.
Czerny, B.
Powiązania:
https://bibliotekanauki.pl/articles/2048955.pdf
Data publikacji:
2019
Wydawca:
Instytut Włókien Naturalnych i Roślin Zielarskich
Tematy:
circulating tumour cells
breast cancer
CytoTrack CT11
liquid biopsy
wolnokrążące komórki nowotworowe
rak piersi
CytroTrack CT11
płynna biopsja
Opis:
Introduction: Plants are a rich source of healing substances. Cancer is a leading cause of death worldwide while breast cancer is the most common cancer among women. Circulating tumour cells (CTCs) are potential founder cells for metastasis. Therefore, their assessment may be used for monitoring of treatment as well as detecting cancer metastatis. Hence, it is suggested that the number of CTCs may be a valuable tumour biomarker during therapy. Objective: The purpose of this study was to detect CTCs in breast cancer and to validate the method of assessment of CTC count using CytoTrack CT11 technology. Methods: MCF-7 cells were sorted by a FACSARIA flow cytometer from blood samples derived from patients who have not been diagnosed with cancer. Identification and quantitative assessment of MCF-7 cells in blood samples were determined by flow sorting. Then, blood samples containing MCF-7 cells or without MCF-7 were scanned with the use of an automated fluorescence scanning microscope. Results: In in vitro model analysing the glass CytoDisc™ with stained MCF-7 cells, we noted the correlation between the amount of observed tumour cells and expected number of tumour cells. Moreover, coefficient of variation in case of the recovery rate of the assumed number of MCF-7 cells was 30%, 17%, 18% and 15%, respectively. Conclusion: Our study suggest that CTCs could be predictive factor in patients with metastatic cancer especially in breast cancer.
Źródło:
Herba Polonica; 2019, 65, 4; 31-36
0018-0599
Pojawia się w:
Herba Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Psychosocial aspect of quality of life of Polish women with breast cancer
Autorzy:
Pacian, A.
Kulik, T.B.
Pacian, J.
Chrusciel, P.
Zolnierczuk-Kieliszek, D.
Jarosz, M.J.
Powiązania:
https://bibliotekanauki.pl/articles/49711.pdf
Data publikacji:
2012
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2012, 19, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Intake of selected food groups in relation to risk of breast cancer
Autorzy:
Oleksiak, A.
Deptała, A.
Dąbrowska-Bender, M.
Religioni, U.
Badowska-Kozakiewicz, A.M.
Powiązania:
https://bibliotekanauki.pl/articles/28761770.pdf
Data publikacji:
2022
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2022, 29, 3; 342-347
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
COUPLES DEALING WITH BREAST CANCER: THE ROLE OF HUSBANDS IN SUPPORTING THEIR WIVES
Autorzy:
Zierkiewicz, Edyta
Mazurek, Emilia
Powiązania:
https://bibliotekanauki.pl/articles/647092.pdf
Data publikacji:
2015
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie
Tematy:
breast cancer survivors, spouses, men as caregivers
Opis:
Aim: The main goal of the article is to showcase how husbands performed the role of caregivers for their wives after breast cancer diagnosis. The researchers analysed this issue by comparing the perspectives of the male caregivers with their wives’ opinions. The wives were active members of Amazon clubs. Background: Partners of women with breast cancer are expected to assume responsibility for taking care of their wives. Simultaneously, however, they are not prepared to fulfil their new duties, nor are they being provided with any professional support in this regard. Method: Semi-structured interviews were conducted with eight married couples, separately with wives and husbands. Results: Husbands perceive their role in their wives’ struggles as primarily supportive and channel any negative emotions via undertaken actions. They support their wives in four ways: by focusing on their wives’ feelings and caring about her, taking part in the healing process, manag- ing the household during the period of their wives’ recovery, and by bringing back normalcy into their lives. Conclusions: Limited knowledge about oncological diseases, deficiencies in the assistance services offered to husbands of women with breast cancer and stereotypes about gender roles contribute to the difficulties men face when taking care of their sick wives. Even the wives active participation in the Amazon movement does not seem to mitigate their problems. 
Źródło:
Studia Humanistyczne AGH; 2015, 14, 2
2084-3364
Pojawia się w:
Studia Humanistyczne AGH
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Principles of follow-up assessments in patients with breast cancer after radical treatment
Autorzy:
Hodorowicz-Zaniewska, Diana
Herman, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1393556.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
breast cancer
treatment follow-up
recommendations
Opis:
A follow-up assessment plan after radical treatment is a part of a comprehensive approach to treating patients with breast cancer. Because breast cancer is the most frequent cancer both worldwide and in Poland, adequate follow-up is important not only for patients but also for economic reasons. Herein, we review current recommendations for follow-up assessments in patients with breast cancer. The main aim of such assessment is detection of early recurrence or tumor presence in the other breast, observation of long-term treatment complications, and creation of multidisciplinary infrastructure that will allow to reduce the risk of recurrence and alleviate physical, mental, and social consequences of treatment.
Źródło:
Polish Journal of Surgery; 2017, 89, 3; 36-39
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Body image in women with breast cancer undergoing surgical treatment - a comparative analysis
Autorzy:
Brandt-Salmeri, Anna
Ilska, Michalina
Kołodziej-Zaleska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1933075.pdf
Data publikacji:
2019
Wydawca:
Politechnika Śląska. Wydawnictwo Politechniki Śląskiej
Tematy:
breast cancer
mastectomy
breast conserving therapy
BCT
breast reconstruction
body image
self-esteem
rak piersi
mastektomia
terapia oszczędzająca pierś
rekonstrukcja piersi
obraz ciała
samoocena
Opis:
Surgery is the most basic treatment in case of breast cancer: it involves a complete or partial removal of the mammary gland. The aim of the study was to assess the body image distress and self-esteem in a group of women with breast cancer undergoing various surgical procedures. The material was collected in a group of 229 women with breast cancer who were divided into subgroups based on the surgery criterion (mastectomy, breast-conserving therapy - BCT and mastectomy with breast reconstruction). The study used the Body Image Scale by Hopwood, Fletcher, Lee and Al Ghazal (2001; Polish adaptation by Brandt-Salmeri and Przybyła-Basista), Rosenberg Self-Esteem Scale - SES (Polish adaptation by Łaguna, Lachowicz-Tabaczek and Dzwonkowka, 2007) and an original survey. Analyses showed, among other things, significant differences in the assessment of discomfort associated with a change in body image depending on the type of surgery. The research also revealed that the assessment depended on differences between the women in terms of age and the time elapsed since the onset of treatment. Negative body image was adversely associated with self-esteem in all studied groups. Body image was significantly related to age and time elapsed since the treatment in the post-mastectomy group. At the same time, it was related only to age in the BCT group and with regards to the breast reconstruction group, the relationship concerned only elapsed time.
Źródło:
Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska; 2019, 141; 7-24
1641-3466
Pojawia się w:
Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hormonal contraceptives and hormone replacement therapy as a possible factor of breast cancer
Autorzy:
Predna, L.
Habanova, M.
Slavikova, E.
Wyka, J.
Powiązania:
https://bibliotekanauki.pl/articles/871417.pdf
Data publikacji:
2015
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
hormonal contraceptive
hormone replacement therapy
disease parameter
breast cancer
risk factor
cancer
human disease
Opis:
Background. Breast cancer is a disease with an increasing incidence, and it originates from several factors. Risk factors of this disease represent a diverse group of parameters, which also include hormonal influences. Objective. The aim of the present study was to determine if there is a relationship between hormonal contraceptives and hormone replacement therapy in patients with diagnosed most common types of breast cancer taking into account the age at which the disease was diagnosed in selected sonographic clinic in the district of Nitra, Slovak Republic. Material and Methods. As a part of an ongoing retrospective study from 2005, a cohort of 300 randomly selected patients aged 25-87 years with diagnosed breast cancer have been monitored in 2012. The age at which breast cancer was diagnosed, and relationship to hormone therapy were analysed based on medical documentation. Results. Among 300 randomly selected patients with a confirmed diagnosis of breast cancer the group at the age of 40-59 was the most numerous (mean age was 53.06±11.25 years). The mean age of 45 patients who were given hormonal contraceptives (HC) was 46.44±7.34 years, whereas the mean age of 82 patients who were subjected to hormone replacement therapy (HRT) was 53.63±6.67 years. In women who took hormonal treatment, breast cancer was diagnosed at the mean age of 50.60±7.56 years, while women who never took HRT or HC, were diagnosed around the age of 53.92±12.35 years. The most common types of cancer were the infiltrating ductal carcinoma and lobular carcinoma. From all patients, the relapse occurred among 14 of them, about 4.86 years later. Only 2 patients had breast cancer on both diagnosed breast. After a surgery, the cancer was observed in 7 patients. The positive family history was confirmed with 34 patients. Conclusions. Nowadays, the breast cancer treatment, especially at early stages, is successful, however, the malignant breast neoplasm remains the most common oncological disease causing the death amongst women. In the assessment of the impact of HC and HRT on breast cancer, it is not possible to provide a clear conclusion, because their influence on the tumour is difficult to verify.
Wprowadzenie. Rak piersi jest chorobą, której występowanie uzależnione jest od wielu czynników. Czynniki te są zróżnicowane, a wśród nich wyróżnia się czynniki hormonalne. Cel. Na podstawie danych medycznych podjęto próbę oceny występowania zależności różnych typów raka piersi u kobiet a stosowaniem antykoncepcji hormonalnej oraz hormonalnej terapii zastępczej. Materiał i metody. Praca stanowi część trwającego od 2005 roku badania stanu zdrowia pacjentek w wieku 25-87 lat. Badaniami objęto kohortę 300 kobiet, u których w 2012 roku zdiagnozowano raka piersi. W badaniach przeprowadzonych na podstawie analizy dokumentacji medycznej oceniano zależność między wiekiem kobiety, w którym zdiagnozowano raka piersi a terapią hormonalną. Wyniki. W grupie 300 kobiet ze zdiagnozowanym rakiem piersi, najliczniejszy udział stanowiły kobiety w wieku 40-59 lat (średnia 53.06±11.25 lat). Wśród pacjentek wyróżniono 45 kobiet stosujące HC (HC – antykoncepcje hormonalną) ze średnim wiekiem 46.44±7.34 lat oraz 82 kobiety stosujące HRT (HRT – hormonalną terapię zastępczą) ze średnim wiekiem w tej grupie 53.63±6.67 lat. Wśród kobiet, które przyjmowały preparaty hormonalne średni wiek wykrycia raka piersi wynosił 50.60±7.56 lat, w porównaniu do kobiet nie stosujących żadnej terapii hormonalnej 53.92±12.35 lat. Wśród badanych kobiet najczęściej stwierdzany był naciekający nowotwór wewnątrzprzewodowy (ductal carcinoma) oraz wewnątrzzrazikowy (lobular carcinoma). U 2 pacjentek stwierdzono dwa rodzaje nowotworu. Wśród 14 pacjentek wykryto nawrót choroby, średni czas od powtórnego zdiagnozowania nowotworu wynosił 4.86 lat. Po operacji chirurgicznej nowotwór wykazano u 7 kobiet. W grupie 34 pacjentek stwierdzono występowanie nowotworu piersi w rodzinie. Wnioski. W obecnych czasach leczenie nowotworu piersi, szczególnie we wczesnych stadiach choroby przynosi satysfakcjonujące rezultaty. Jednak złośliwe postacie nowotworu nadal są przyczyną wysokiej śmiertelności wśród kobiet. W niniejszym badaniu nie udało się wskazać istotnej zależność pomiędzy występowaniem nowotworu piersi a stosowaniem HC i HRT wśród badanych kobiet.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2015, 66, 3
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficacy and safety of non-pegylated liposomal doxorubicin in metastatic breast cancer therapy
Autorzy:
Wójcik, Elżbieta
Kufel-Grabowska, Joanna
Gierba-Tomczyk, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1062503.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
breast cancer
non-pegylated liposomal doxorubicin
treatment
Opis:
Breast cancer is the most frequently diagnosed female cancer in Poland (over 17,500 women). Anthracyclines have become one of the most important drugs in breast cancer systemic treatment. In the treatment of metastatic disease combination chemotherapy with doxorubicin provides the objective response rate of 60–85%, and the median time of progression-free survival is about 12 months. Non-pegylated liposomal doxorubicin (NPLD) in combination with cyclophosphamide is associated with a lower risk of cardiotoxicity, higher efficacy and more favourable toxicity profile as compared with conventional anthracycline regimes. Two cases of females patients treated with NPLD described in this article demonstrate the importance of the choice of chemotherapy, professional monitoring, early detection and treatment of adverse effects. Non-pegylated liposomal doxorubicin ordained in systemic treatment of stage IV breast cancer prolongs survival and enhances the quality of life. It is a reasonable option for palliative therapy.
Źródło:
OncoReview; 2017, 7, 4; 162-167
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Satisfaction with life among women with breast cancer - selected demographic and social factors
Autorzy:
Cipora, E.
Konieczny, M.
Karwat, I.D.
Roczniak, W.
Babuska-Roczniak, M.
Powiązania:
https://bibliotekanauki.pl/articles/2081604.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
breast cancer
demographic and social factors
satisfaction with life
Opis:
Objective. The aim of the study was evaluation of satisfaction with life among women ill with breast cancer, with consideration of selected demographic and social factors. Materials and method. In the study participated 121 patients from the Sub-Carpathian Oncology Centre in Brzozów, Poland, who had undergone surgical treatment due to breast cancer. The method of a diagnostic survey was used. The research instruments were an author-constructed questionnaire and the Satisfaction with Life Scale. Results. Women who received surgical treatment due to breast cancer evaluated their satisfaction with life on a mediocre level. Younger patients had a lower satisfaction with life than those who were older. Women living in urban areas evaluated their satisfaction with life in more positive terms than rural women. In turn, education level, marital status and material standard had no effect on the level of satisfaction with life among the women in the study. Conclusions. According to the SWLS, women with the diagnosis of breast cancer obtained a mean result of 5.64 sten scores Younger women evaluated their satisfaction with life in more positive terms than those who were older. Women who lived in urban areas obtained a considerably higher result according to the SWLS, compared to rural inhabitants. Marital status, education level, material standard and occupational activity of the women were insignificant in the respondents’ evaluation of satisfaction with life.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 2; 314-319
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cancer-related microagiopathic hemolytic anemia in a patient with breast cancer - diagnostic difficulties
Autorzy:
Skwierawska, Kamila
Woźniak, Krzysztof
Waszczuk-Gajda, Anna
Drozd-Sokołowska, Joanna
Kacprzyk, Piotr
Chehab, Marita Rachid
Boguradzki, Piotr
Jędrzejczak, Wiesław Wiktor
Basak, Grzegorz Władysław
Powiązania:
https://bibliotekanauki.pl/articles/2032969.pdf
Data publikacji:
2020-12-31
Wydawca:
Medical Education
Tematy:
cancer-related microangiopathic hemolytic anemia
CR-MAHA
breast cancer
thrombotic microangiopathy
thrombocytopenia
Opis:
Cancer-related microangiopathic hemolytic anemia is rarely recognized as a paraneoplastic syndrome with a very poor prognosis in cancer patients. The treatment and prognosis are significantly different from that in other thrombotic microangiopathies, such as thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. The case of described patient demonstrates the diagnostic difficulties in diagnosing the causes of hemolytic anemia in patient with breast cancer and appropriate treatment.
Źródło:
OncoReview; 2020, 10, 4; 134-138
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Classification of breast cancer malignancy using cytological images of fine needle aspiration biopsies
Autorzy:
Jeleń, Ł.
Fevens, T.
Krzyżak, A.
Powiązania:
https://bibliotekanauki.pl/articles/908052.pdf
Data publikacji:
2008
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
złośliwość guza
klasyfikacja guza
rak sutka
skala Blooma-Richardsona
automated malignancy grading
FNA grading
SVM
breast cancer grading
Bloom-Richardson
Opis:
According to the World Health Organization (WHO), breast cancer (BC) is one of the most deadly cancers diagnosed among middle-aged women. Precise diagnosis and prognosis are crucial to reduce the high death rate. In this paper we present a framework for automatic malignancy grading of fine needle aspiration biopsy tissue. The malignancy grade is one of the most important factors taken into consideration during the prediction of cancer behavior after the treatment. Our framework is based on a classification using Support Vector Machines (SVM). The SVMs presented here are able to assign a malignancy grade based on preextracted features with the accuracy up to 94.24%. We also show that SVMs performed best out of four tested classifiers.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2008, 18, 1; 75-83
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Text mining approach to analyse the relation between obesity and breast cancer data
Autorzy:
Kumar, A.
Thakur, P.
Gupta, K.
Pal, A.
Powiązania:
https://bibliotekanauki.pl/articles/10908.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Opis:
Biomedical research needs to leverage and exploit large amount of information reported in scientific publication. Literature data collected from publications has to be managed to extract information, transforms into an understandable structure using text mining approaches. Text mining refers to the process of deriving high-quality information from text by finding relationships between entities which do not show direct associations. Therefore, as an example of this approach, we present the link between two diseases i.e. breast cancer and obesity.Obesity is known to be associated with cancer mortality, but little is known about the link between lifetime changes in BMI of obese person and cancer mortality in both males and females. In this article, literature data for obesity and breast cancer was obtained using PubMed database and then methodologies which employs groups of common genes and keywords with their frequency of occurrence in the data were used, aimed to establish relation between obesity and breast cancer visualized using Pi-charts and bar graphs. From the data analysis, we obtained 1 gene which showed the link between both the diseases and validated using statistical analysis and disease-connect web server. We also proposed 8 common higher frequency keywords which could be used for indexing while searching the literature for obesity and breast cancer in combination.
Źródło:
International Letters of Natural Sciences; 2015, 44
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Indications for sexology consultation in women after surgical treatment due to breast cancer
Autorzy:
Streb, J.
Jabłonski, M.J.
Słowik, A.
Babczyk, D.
Jach, R.
Powiązania:
https://bibliotekanauki.pl/articles/2083232.pdf
Data publikacji:
2019
Wydawca:
Instytut Medycyny Wsi
Tematy:
mastectomy
sexual health
sexual dysfunction
desire
orgasm
Opis:
Introduction and objectives. Surgical treatment due to brest cancer have an impact on women sexuality. There is a need for research about effective indications for sexology consultation in women after such treatment. The aim of this study is to determine the indications for sexology consultation in women after surgical treatment for breast cancer. Materials and method. We tested 42 women patients diagnosed with breast cancer who had undergone mastectomy 3 months before the study. 3 months after the surgery the women were surveyed using the Polish version of FSFI assessing sexual functioning in women. The result of PL-FSFI were compared with the control group. Results. It was found that the mean score of PL-FSFI in the study group 3 months after the surgery was 13.33 points (score range: 1.2–31.7; median 8.3 points) with a statistically significant difference in terms of areas: desire, arousal, lubrication and orgasm in favour of the control group. The total score of PL-FSFI was significantly lower in women after mastectomy than in women after breast-conserving surgery. It has been shown that sexually active women in whom the surgery concerned the right breast (on the side of the dominant hand) scored lower on the scale “sexual functioning” of QLQ-BR-23 than women with surgery of the left breast, with this difference being statistically significant. There was a statistically significant correlation between the baseline performance status on the Zubrod scale and the scales: desire, lubrication and satisfaction of PL-FSFI. Living in a small town proved to be statistically significant for predicting a lower risk of sexual dysfunction among the surveyed women. Conclusions. The women who underwent surgery due to breast cancer had a higher risk of sexual dysfunction compared to the general population. Higher risk of sexual dysfunction especially concerns women after mastectomy, those who underwent breast surgery on the side of the dominant hand, and those with a worse preoperative overall level of functioning of ≥ 1 point on the Zubrod scale. A lower risk of disorders was observed in women living in smaller towns. The above factors indicate the advisability for sexology consultation in women with breast cancer.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 2; 379-384
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Obrazowanie mikrofalowe na przykładzie nowotworu gruczołu piersiowego
Microwave imaging for breast cancer detection
Autorzy:
Michałowska-Samonek, J.
Wac-Włodarczyk, A.
Powiązania:
https://bibliotekanauki.pl/articles/159060.pdf
Data publikacji:
2009
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Elektrotechniki
Tematy:
nowotwór gruczołu piersiowego
obrazowanie mikrofalowe
FDTD
metoda różnic skończonych w dziedzinie czasu
Opis:
Praca niniejsza ma na celu przedstawienie możliwości, jakie daje zastosowanie tomografii mikrofalowej do detekcji nowotworu gruczołu piersiowego. W celu uproszczenia zagadnienia założono, że model gruczołu piersiowego jest homogeniczny, a jego parametry elektryczne (przenikalność elektryczna względna i konduktywność) opisane są równaniem Debye'a. Parametry elektryczne zostały przeliczone dla częstotliwości 6 GHz. Artykuł przedstawia właściwości dielektryczne tkanki dla fantomu piersi. Zmiany patologiczne obrazujące nowotwór gruczołu piersiowego naniesione są na sztuczne modele piersi, o których mowa w pracy.
The aim of this paper is the application of microwave tomography to breast cancer detection. In order to investigate the problem, the authors assumed that the model of breast is homogeneous and its electrical parameters i.e. dielectric constant and conductivity are described (approximately) by Debye's formula. The model, its dimensions and electrical parameters calculated for frequency of 6 GHz. This article introduced the approach to the dielectric properties of breast tissue inside the breast phantom. Artificial changes, such as changes to models illustrating the tumor may be achieved on the healthy breast phantoms, as referred to in the workplace.
Źródło:
Prace Instytutu Elektrotechniki; 2009, 241; 81-95
0032-6216
Pojawia się w:
Prace Instytutu Elektrotechniki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pathophysiological roles of ERα in the ER signaling mediated oncogenesis of breast cancer
Autorzy:
Abda Neja, Sultan
Powiązania:
https://bibliotekanauki.pl/articles/2040136.pdf
Data publikacji:
2020-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
breast, cancer
estrogen receptor alpha
oncogenesis
Opis:
Introduction. Estrogen receptors (ER) are members of nuclear receptors that act in the ER signaling pathway regulating the pathophysiology of hormone-responsive target cells including breast tissue. Aim. This detailled review literature was written on the pathophysiology of ER signaling as well as the effect altered ERα and associated pathway derangement in the oncogenesis of breast cancer. Material and methods. This review was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Analysis of the literature. In this pathway, estrogen receptor alpha (ERα) is a key estradiol-17β (E2) induced transcription factor that has been implicated in the initiation and development of the major fraction of breast cancers. Hence understanding the ERα-mediated ER signaling that results in alterations from normal phenotypic features of breast tissue to the oncogenic features of breast cancer is important. The oncogenic effect of ERα in ER signaling is driven by combinations of molecular assets within the cancer cells. Normally, the transcriptional activity of ERα is controlled by tight regulation of its protein level inside the cells. Altered stability and activity of ERα due to its phosphorylation, ubiquitination, glycosylation, sumoylation, and acetylation events can trigger oncogenic ER signaling. Conclusion. The function and activity of ERα is also modulated by its interaction with coregulators as well as crosstalk with oncogenic factors from other oncogenic pathways. These all events increase the complexity of the progression of ER+ breast cancer and its response to endocrine therapy
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 4; 289-302
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Efficacy and safety of liposomal doxorubicin in a patient treated for metastatic breast cancer
Autorzy:
Streb, Joanna
Słowik, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1065206.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
breast cancer
cardiotoxicity
liposomal doxorubicin
Opis:
Liposomal doxorubicin is a newer form of chemotherapeutic agents that, due to its own special properties, preferably accumulates in cancer tissue. On the other hand, it shows lower affinity to cardiomyocytes and in this way is less cardiotoxic. As a result of that, there is the possibility to use liposomal form of doxorubicin until disease progression or chemotherapy intolerance in palliative setting, without treatment cessation after reaching the maximum cumulative dose of conventional doxorubicin. In this article we describe the case of a female patient diagnosed with breast cancer who was primary treated with adjuvant treatment, including chemotherapy and in whom a disease recurrence occurred after seven years of observation. As a primary palliative treatment the patient received chemotherapy based on liposomal doxorubicin and cyclofosphamide with a very good tolerance. The initial response was partial remission in lungs and in mediastinal lymph nodes. During the whole course of therapy there were no pathological changes in electrocardiogram, no signs and no symptoms of congestive heart failure, and the left ventricular ejection fraction was within normal limits.
Źródło:
OncoReview; 2015, 5, 2; A67-70
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Non-pegylated liposomal doxorubicin plus capecitabine as first-line treatment in metastatic breast cancer
Autorzy:
Plecka, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1064811.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
breast cancer
chemotherapy
new regimen
non-pegylated liposomal doxorubicin
Opis:
Purpose: To determine the toxicity and efficacy profile of non-pegylated doxorubicin in combination with capecitabine administered according to LipAX regimen. Materials and methods: The analysis included 5 female patients undergoing first-line treatment for metastatic breast cancer. Patients received non-pegylated doxorubicin intravenously and oral capecitabine at usual doses used for monotherapy, until disease progression or unacceptable toxicity. Results: Patients received a total of 26 complete treatment cycles according to LipAX regimen. During treatment, 15 toxicities occurred, including 7 adverse events with grade 3 severity. Only two haematological toxicities were observed, and the other 13 were of a non-haematological nature. Only one patient experienced no adverse events. Apart from symptomatic treatment, the capecitabine dose was reduced twice and the non-pegylated doxorubicin once. Positive clinical outcomes were observed in 4 patients, and disease progression was reported in the case of 1 patient in the course of the treatment. The median time to disease progression was 10.4 months, and the median overall survival was 34.2 months. During the 54-month follow-up, 4 of the patients died. The surviving patient continues treatment. Conclusions: Therapy according to the LipAX regimen was relatively well tolerated, however, since the majority of patients discontinued treatment due to adverse events, and not disease progression, an adequate reduction in the cytostatic doses should be considered. The use of the LipAX regimen may contribute to the achievement of long-term remission in some patients, a fact that encourages further studies on this form of therapy.
Źródło:
OncoReview; 2016, 6, 4; A193-198
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Anticancer activity of some polyamine derivatives on human prostate and breast cancer cell lines
Autorzy:
Szumilak, Marta
Galdyszynska, Malgorzata
Dominska, Kamila
Stanczak, Andrzej
Piastowska-Ciesielska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1038652.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
polyamine derivatives
prostate cancer
breast cancer
mitochondrial potential
cell cycle
apoptosis
Opis:
The aim of this study was to expand our knowledge about anticancer activity of some polyamine derivatives with quinoline or chromane as terminal moieties. Tested compounds were evaluated in vitro towards metastatic human prostate adenocarcinoma (PC3), human carcinoma (DU145) and mammary gland adenocarcinoma (MCF7) cell lines. Cell viability was estimated on the basis of mitochondrial metabolic activity using water-soluble tetrazolium WST1 to establish effective concentrations of the tested compounds under experimental conditions. Cytotoxic potential of polyamine derivatives was determined by the measurement of lactate dehydrogenase activity released from damaged cells, changes in mitochondrial membrane potential, the cell cycle distribution analysis and apoptosis assay. It was revealed that the tested polyamine derivatives differed markedly in their antiproliferative activity. Bischromane derivative 5a exhibited a rather cytostatic than cytotoxic effect on the tested cells, whereas quinoline derivative 3a caused changes in cell membrane integrity, inhibited cell cycle progression, as well as induced apoptosis of prostate and breast cancer cells which suggest its potential application in cancer therapy.
Źródło:
Acta Biochimica Polonica; 2017, 64, 2; 307-313
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Epidemiological profile and distribution of prognostic factors in invasive breast cancer among Algerian women
Autorzy:
Elbasyouni, Amel
Saadi, Leila
Baha, AbdelKarim
Powiązania:
https://bibliotekanauki.pl/articles/2047226.pdf
Data publikacji:
2021-09-22
Wydawca:
Medical Education
Tematy:
breast cancer
epidemiology
biomarkers
immunohistochemistry
prognostic
Opis:
Although the widespread of early screening and advanced medical therapies, the breast cancer incidence rate continues to rise among Algerian women. This retrospective study investigated mammary lesions’ epidemiological profile and histopathological characteristics and evaluated primary invasive breast cancer prognostic factors. We found that the incidence of breast cancer increases in middle- aged women between 40 and 60 years. Scarff Bloom Richardson grade II predominates in invasive breast cancer samples. In this study, molecular profiling shows that 82.1% of invasive tumours are hormone receptor-positive. A significant correlation is observed between the age of the patient and the SBR grade (p = 0.001) and with the hormone receptor expression (p = 0.001). In addition, the tumour grade is significantly correlated to oestrogen and progesterone receptor expression (p = 0.000; p = 0.000, respectively). Twenty-two per cent of cases were human epidermal growth factor receptor 2-positive. The Ki-67 proliferation index is expressed in 91% of breast cancer patients and was significantly associated with Scarff Bloom Richardson grade (p = 0.030), the progesterone receptor expression (p = 0.029) and with human epidermal growth factor receptor 2-positivity (p = 0.023). Primary breast cancer with a high grade is more frequent (31%) in young women under 40 years old, presenting 17% of our population. In summary, breast cancer patients in Algeria develop an unfavourable profile. Immunohistochemistry assay has played a pivotal role in assessing breast cancer predictive biomarkers improving the tumour behaviour and response to treatment.
Źródło:
OncoReview; 2021, 11, 4; 95-101
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Complications in the sexual activity of women after a surgical intervention for breast cancer
Autorzy:
Kusz-Marcol, J.
Konietzka, M.
Zycinska, J.
Powiązania:
https://bibliotekanauki.pl/articles/1651.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Opolski. Instytut Nauk o Zdrowiu
Tematy:
human disease
woman
breast cancer
mastectomy
surgical intervention
sexual activity
complication
PLISSIT model
Opis:
Breast cancer is one of the most common types of cancer among women. The most common form of treatment of this illness is a surgical intervention consisting of a partial or radical mastectomy. This article describes the psychological impacts of this experience on the frequency and occurrence of complications in the sexual activity of women and to determine the role that medical staff can play in helping patients cope with these challenges. The loss of a breast can have negative effects on a woman’s emotional state, specifically in terms of feeling feminine and the relationship with her partner. This is often reflected in a reduced quality of life. The care extended to post-mastectomy patients should routinely include an assessment of possible sexual dysfunctions and monitoring of how such dysfunctions are coped with. The PLISSIT model makes it possible to indicate how post-mastectomy patients may be effectively supported by medical staff. It serves to define a group of patients requiring specialist help. It also aims to initiate a conversation about the difficulties of functioning in this sphere, to provide general information and change existing perceptions, to give specific advice on making referrals to a specialist, and to consider these types of existing problems. The described intervention model is applicable to individual work, as well as to work with couples and groups. This method depends on the type of intervention desired and on the current psychophysical state of the patient and her readiness to start a conversation concerning sexual activity.
Źródło:
Medical Science Pulse; 2018, 12, 2
2544-1558
2544-1620
Pojawia się w:
Medical Science Pulse
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Level and conditioning of knowledge about breast cancer displayed by women in perimenopausal age
Autorzy:
Bogusz, R.
Humeniuk, E.
Walecka, I.
Bojar, I.
Powiązania:
https://bibliotekanauki.pl/articles/49933.pdf
Data publikacji:
2016
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2016, 23, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Komentarz do recenzji książki Pink Ribbon Blues: How Breast Cancer Culture Undermines Women’s Health
A Comment by the Author of Pink Ribbon Blues: How Breast Cancer Culture Undermines Women’s Health
Autorzy:
Sulik, Gayle
Powiązania:
https://bibliotekanauki.pl/articles/686419.pdf
Data publikacji:
2012
Wydawca:
Wydawnictwo Naukowe Dolnośląskiej Szkoły Wyższej
Źródło:
Studia Poradoznawcze; 2012, 1
2450-3444
Pojawia się w:
Studia Poradoznawcze
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The breast-conserving surgery of women with breast cancer in Podlaskie voivodship (Poland). Population study
Autorzy:
Maslach, D.
Krzyzak, M.
Szpak, A.
Bojar, I.
Bielska-Lasota, M.
Owoc, A.
Powiązania:
https://bibliotekanauki.pl/articles/51887.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Tematy:
breast-conserving surgery
woman
breast cancer
Polska
Podlasie region
cancer control
human population
Opis:
Introduction. The results of breast cancer treatment depend mainly on better detection in mammography screening and, consequently, a higher proportion of women with early stage of the disease. They depend also on a better access to health care services and the effectiveness of oncological treatment. One of the methods of breast cancer control is a breastconserving surgery. With a proper patients’ classification for the treatment, the results of the breast-conserving surgery do not differ in relation to mastectomy. That’s why, the availability of breast-conserving surgical methods is particularly important, especially in a population in which a population screening is conducted. Objective. The analysis of the selected aspects of the breast cancer treatment’s standard in Podlaskie Voivodeship. Patients and methods. In years 2001–2002, 709 cases of women with breast cancer were reported to the Voivodeship Cancer Registry in Bialystok. 659 women were diagnosed with a primary invasive breast cancer. Based on a cohort of 499 women treated with radical methods the following indicators, recommended by WHO for the evaluation of the breastconserving surgery’s availability, were calculated: a percentage of patients with whom breast-conserving surgery was used, a proportion of breast cancer cases receiving post-operative breast radiotherapy after breast-conserving surgery and a proportion of breast-conserving surgery in pT1 cases. Results. The breast-conserving surgery has been used much less frequently in Podlaskie Voivodeship than in Western Europe, but more frequently than in Poland in general. Conclusion. It should be aimed to provide a surgical treatment with the use of breast-conserving surgical methods to the highest possible percentage of patients. The increase of the percentage of patients treated with breast-conserving surgery methods can be a result of an effective screening realisation.
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Therapy with liposomal doxorubicin in patients with advanced breast cancer after treatment with classical doxorubicin
Autorzy:
Kufel-Grabowska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1065267.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
breast cancer
complications of oncological therapy
non-pegylated liposomal doxorubicin
Opis:
Breast cancer is the most common female cancer in the world and in Poland. The improvement of diagnostic and therapeutic methods has led to patients’ longer life expectancy. It has also made breast cancer a chronic disease, increasing the risk of late side effects of oncological therapy. More cardiovascular diseases are diagnose in patients over 65 with an oncological history than in those without it and therefore much effort must be made to maximise effectiveness of the therapy with as few side effects as possible. The article presents two breast cancer patients treated with big doses of liposomal doxorubicin with a good response and almost no side effects.
Źródło:
OncoReview; 2015, 5, 3; A103-108
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Body image and the psychological and behavioural indices of distress in female breast cancer patients
Autorzy:
van Oers, Helena
Powiązania:
https://bibliotekanauki.pl/articles/1031941.pdf
Data publikacji:
2020
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
behavior
body image
breast cancer
psychological symptoms
stress
Opis:
Psychological distress associated with body image disorders in patients with breast cancer is well described in the literature. Given the known insults to body image caused by both disease and oncological treatment, body image distress is commonplace within this patient population. Stress is also a frequent sequela of a diagnosis of and treatment for cancer and may manifest various forms. This study undertook to investigate the nature of stress and body image distress within a cohort of 80 female breast cancer patients drawn from three outpatient cancer treatment facilities in the Durban, South Africa region and to examine its correlation with psychological and behavioural indices reported by these patients as compared to a group of 80 female patients undergoing treatment for other types of cancer. The results indicated that although there were no significant differences between the two groups in terms of depressive symptomatology and measures of self-esteem, where scores largely fell within normal ranges, the breast cancer patients experienced higher levels of body image dissatisfaction as compared to the other group and that stress tended to be expressed in psychological and behavioural indices as opposed to physiological expression.
Źródło:
World Scientific News; 2020, 140; 172-184
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Administration of liposomal doxorubicin in patients with metastatic breast cancer and significant concomitant cardiovascular conditions
Autorzy:
Bryjak, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/773565.pdf
Data publikacji:
2014
Wydawca:
Medical Education
Tematy:
NLPD
cardiotoxicity
conventional anthracyclines
liposomal doxorubicin
metastatic breast cancer
Opis:
A frequent dilemma faced by an oncologist about to take decision on a chemotherapeutic regime for patients with metastatic breast cancer is how to maintain balance between the expected treatment efficacy and predictable adverse events. In the case of anthracyclines what is problematic is their significant cardiotoxicity, in particular with reference to patients previously treated with them as part of adjuvant therapy. A relatively new method is replacement of conventional doxorubicin with its non-pegylated form, encapsulated in liposomes, which is capable of minimizing the side effects without compromising its therapeutic index. The present article discusses three cases of patients treated with non-pegylated liposomal doxorubicin (NPLD) as first-line chemotherapy administered for metastatic breast cancer. In all three cases considerable clinical improvement was observed, involving remission of pathological lesions and good quality of life.
Źródło:
OncoReview; 2014, 4, 4; A148-A154
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of Topotecan on oxidative stress in MCF-7 human breast cancer cell line
Autorzy:
Timur, Mujgan
Akbas, S
Ozben, Tomris
Powiązania:
https://bibliotekanauki.pl/articles/1041340.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
MCF-7 cells
Topotecan
antioxidants
breast cancer
oxidative stress
Opis:
Purpose. Topotecan, a semisynthetic water-soluble derivative of camptothecin exerts its cytotoxic effect by inhibiting topoisomerase I and causes double-strand DNA breaks which inhibit DNA function and ultimately lead to cell death. In previous studies it was shown that camptothecin causes ROS formation. The aim of this study was to investigate if Topotecan like camptotecin causes oxidative stress in MCF-7 human breast cancer cell line. Determining the oxidant effect of Topotecan may elucidate a possible alternative mechanism for its cytotoxicity. Experimental design. MCF-7 cells were cultured and exposed to Topotecan for 24 h at 37°C. The viability of the cells (% of control) was measured using the colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Lipid peroxidation (TBARS), protein oxidation (carbonyl content), sulfhydryl, glutathione (GSH) levels, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities were determined in MCF-7 cells with and without Topotecan incubation. Results. We found the IC50 concentration of Topotecan as 0.218 µM in MCF-7 cells. This concentration of Topotecan was used in the incubations of the cells. Our data indicated increased oxidative status, as revealed by increased lipid peroxidation and protein oxidation, and decreased GSH and sulfhydryl levels in MCF-7 cells exposed to Topotecan compared to control cells. In contrast, there was a slight increase in SOD and a significant increase in GPx and catalase activity in MCF-7 cells incubated with Topotecan compared to the control. Conclusions. These results support our hypothesis that Topotecan increases oxidative stress in MCF-7 cells.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 897-902
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acceptance of illness after surgery in patients with breast cancer in the early postoperative period
Autorzy:
Nowicki, Andrzej
Krzemkowska, Elżbieta
Rhone, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1394286.pdf
Data publikacji:
2015
Wydawca:
Index Copernicus International
Tematy:
breast cancer
surgical treatment
acceptance of the disease
Opis:
The breast cancer is the most common cancer in women, both in Poland and in the world. Consequences entail a disruption in the physical, psychological and social functioning. The aim of the study was to assess the acceptance of illness by patients treated for breast cancer in the early postoperative period. Material and methods. The research was conducted on the group of 100 consecutive patients aged 32‑80 years (median 56 years) who underwent surgery for breast cancer in the Centre of Oncology in Bydgoszcz w 2014 roku. 68 of women had mastectomy, 32 of women had conservative surgery. Polling was conducted in the early period after surgery. The original questionnaire containing closed questions the scale of acceptance of the disease (AIS) as well as mental adaptation to cancer (Mini-Mac) was used in the study. Results. 38% of patients had high acceptance of the disease, 48% averageand 14% had low acceptance. Patients after conservative surgery had a higher average values for the mental strategies to cope with the disease, for the fighting spirit (23.1), helplessness and hopelessness (13.5), positive revaluation (23), the patients had a lower average (16.5) in the strategy to absorb anxiety. Patients after conservative surgery had a higher average for constructive style (2.6) but lower for destructive style (1.5). High level of mental coping with the disease was observed in 53%of patients with constructive style and 4% of patients with destructive style. While, a low level of mental coping with the dosease was observed in 5% of patients with constructive style and 46% of patients with destructive style. Conclusions. Almost half of women after mastectomy or conservative surgery had an average acceptance of the disease. The disease was accepted best by educated women living in the cities, whitecollar workers with a good economic situation. The following factors were affected the better management of the disease, in order: age, education, current occupation and economic situation, while the type of surgery did not affect better management. More than half of women, regardless of the type of surgery reflected the high level of constructive style.
Źródło:
Polish Journal of Surgery; 2015, 87, 11; 539-550
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gender, Power, and Feminisms in Breast Cancer Advocacy: Lessons from the United States and Poland
Autorzy:
Sulik, Gayle
Zierkiewicz, Edyta
Powiązania:
https://bibliotekanauki.pl/articles/438009.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:
breast cancer
epistemology
feminism
gender
health social movements
cross-national comparison
Opis:
The United States breast cancer movement helped to transform breast cancer’s social and medical landscape domestically and, in some ways, internationally. However, differences in gender identities, power relations, and the role of feminism(s) cross-culturally also shaped breast cancer advocacy itself. After giving a brief introduction to the socio-historical context of the U.S. and Polish breast cancer movements, this article illuminates some of the linkages and divergences between the United States and Poland to demonstrate the role of gender and power in social movements that concentrate exclusively on women’s (health) issues, namely breast cancer. This comparison of social phenomena from two countries illuminates the impact of cultural patterns on models of activism as they relate to feminism and traditional gender roles.
Źródło:
Journal of Gender and Power; 2014, 1; 111-145
2391-8187
Pojawia się w:
Journal of Gender and Power
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Abnormal FHIT gene transcript and c-myc and c-erbB2 amplification in breast cancer.
Autorzy:
Kowara, Renata
Gołębiowski, Filip
Chrzan, Paweł
Skokowski, Jaroslaw
Karmolinski, Andrzej
Pawełczyk, Tadeusz
Powiązania:
https://bibliotekanauki.pl/articles/1043760.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
amplification
c-myc
FHIT transcripts
breast cancer
c-erbB2
Opis:
Searching for ways to improve the characterization of breast cancer we examined the relationship between the status of the FHIT gene transcript and amplification of c-myc and the c-erbB2 oncogene. Abnormal FHIT transcript was detected in 32 of 79 cancers examined. The presence of Fhit protein estimated by Western blots was evident only in cancers exhibiting a normal-sized FHIT transcript. This indicates that abnormal FHIT transcripts observed in our study did not encode any Fhit protein or the amount of such protein was very low. There was no association between the presence of aberrant FHIT gene transcript with age, tumor size, estrogen and progesterone receptor status, local metastases and histological grading. However, the abnormalities in FHIT gene transcripts were observed with different frequency depending on the histopathological type of the tumor. The aberrant FHIT transcript was detected in 60% of lobular cancers and only in 28% of ductal cancers. Analyzing the occurrence of c-myc and c-erbB2 amplification and the presence of aberrant FHIT gene transcripts we found that the aberrant FHIT transcript more frequently occurred in tissues with c-myc amplification. There was a significant (P <0.05) correlation between the occurrence of the aberrant FHIT gene transcript with accompanying c-myc amplification and positive lymph node status. However, in order to evaluate the predictive value of these findings in breast cancer, an extended clinical follow up will be necessary.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 341-350
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Gamma-amino butyric acid (GABA) level as an overall survival risk factor in breast cancer
Autorzy:
Brzozowska, Anna
Burdan, Franciszek
Duma, Dariusz
Solski, Janusz
Mazurkiewicz, Maria
Powiązania:
https://bibliotekanauki.pl/articles/989525.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
breast cancer
e-cadherin
gaba/ γ -amino butyric acid/
prognostic factors
prognosis
Opis:
Introduction and objective. The γ-amino butyric acid (GABA) plays important role in the proliferation and migration of cancer cells. The aim of the study was to evaluate the level of GABA in breast cancer, in relation to clinical and epidemiological data. Materials and method. The study was conducted on 89 patients with breast cancer in stage I-II. GABA level was assessed using spectrofluorometric method in tumour homogenates. Immunoexpression of E-cadherin was evaluated histologically on paraffin fixed specimens. Overall and disease-free survival was assessed for a 15-year interval period. Results. Median overall survival was significantly longer (127.2 months) in patients with a high level of GABA (>89.3 μg/1), compared with a group with a low level of the amino acid (106.4 months). Disease-free survival was insignificantly different – 99 and 109 months, respectively. A significantly longer overall survival (131.2 months) was seen among patients with a high level of GABA and positive E-cadherin immunoexpression, compared with a group characterized by a low level of GABA and lack of E-cadherin immunorectivity (98.1 months). The co-existence of negative immunoexpression of E-cadherin and low GABA concentration resulted in a six-fold increase in the risk of death (HR=6.03). Conclusion. GABA has a significant prognostic value in breast cancer. Co-existence of a low level of GABA and loss of E-cadherin immune-expression seems to be a new, independent, and negative prognostic marker of the neoplasm.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Results of a multi-centre survey concerning the treatment of hormone-dependent breast cancer in Poland in 2009–2013
Autorzy:
Jagiełło-Gruszfeld, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1065050.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
breast cancer
hormonal therapy
Opis:
In order to present a reliable picture of hormone-dependent breast cancer treatment in Poland, an on-line survey has been conducted in 19 oncology centres. As a result, data on the treatment of 486 patients have been obtained (405 of them initially presenting with stage I–III of disease advancement, and 81 representing stage IV). It has been concluded that in the majority of cases the treatment in question involves combined therapy, including chemotherapy, hormonal therapy, targeted molecular therapy, radiotherapy, and surgical methods with reference to the group of patients subjected to radical treatment.
Źródło:
OncoReview; 2015, 5, 1; A21-A26
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Patient with metastatic breast cancer presenting as acute cholecystitis with one-year survival on hormonotherapy
Autorzy:
Zamkowski, Mateusz
Kąkol, Michał
Makarewicz, Wojciech
Ropel, Jerzy
Bobowicz, Maciej
Powiązania:
https://bibliotekanauki.pl/articles/1392993.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
breast neoplasm
advanced cancer
metastatic disease
Acute cholecystitis
gallbladder
laparoscopic cholecystectomy
Opis:
Breast cancer has high metastatic potential with distant metastases involving mainly lungs, liver and bones. Less frequently it gives distant spread to other organs. Herein we would like to present a very rare case of an acute cholecystitis which turned out to be a metastatic breast cancer in previously healthy woman. A female patient, 64-years old, presented to the emergency department with symptoms of biliary colic and acute abdomen. During the emergency cholecystectomy, we diagnosed the gallbladder empyema with thickened wall. There were also multiple metastatic nodules in the peritoneal cavity and an excessive amount of free fluid. The emergency physicians diagnosing female patient with the acute abdominal symptoms and a breast cancer history might suspect malignant spread into abdominal organs including gallbladder. On the other hand, acute cholecystitis symptoms might be the first symptoms of metastatic process in the gallbladder from the unknown primary source, which may be breast.
Źródło:
Polish Journal of Surgery; 2017, 89, 4; 46-49
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Knowledge about prevention, risk factors and treatment in women with diagnosed breast cancer. Whether the disease affects their healthy behaviour?
Autorzy:
Nowicki, Andrzej
Rusak, Karolina
Rhone, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1065232.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
breast cancer
knowledge
prevention
Opis:
Objective. The assessment of knowledge about prevention and risk factors of women with diagnosed breast cancer. Material and methods. The study involved 100 women aged from 28 to 82 years (median 56.2 years) who were treated at the Oncology Center in Bydgoszcz in 2014 for breast cancer. Author’s original questionnaire containing questions on knowledge about breast cancer as well as environmental and demographic data was used in this research. Results. Self-examination of a breast was made by 83% of women, 85% of women benefited from invitations for mammography. 56% of women knew how often mammography should be repeated but only 28% knew at what age it should be started. Tumor in a breast (20.5%) and “pulling” nipples (14.4%) were the most frequently reported symptoms of a cancer. In terms of risk factors, genetics (32.2%) and unhealthy lifestyle (16.3%) were the factors pointed by women most often. Every third women indicated only one factor while every four indicated three factors. 69% of the respondents increased their knowledge after falling ill, from the Internet (20.5%) as well as from information leaflets and brochures (16.6%). Women’s knowledge about breast cancer was at the edge of low and average levels and the average value was 11.7 points. More knowledge had women with higher education 12.95 points, single 12.9 and young women 12.3. Conclusions. The knowledge about the disease among women with diagnosed breast cancer was unsatisfactory and did not depend on age, marital status, place of residence, type of work but on education level only. Older and uneducated women had less knowledge, particularly about factors increasing the risk of developing the disease. The Internet, information leaflets and brochures were the primary source of knowledge about the disease, not a doctor or a nurse. Women with breast cancer were aware of the importance of preventive tests. They declared that they can perform self-examination. The most frequently reported symptoms of cancer are tumor and “pulling” nipples.
Źródło:
OncoReview; 2015, 5, 2; A81-90
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nowotwór piersi – problemy i jakość życia kobiet po mastektomii
Breast cancer – problems and quality of women’s life after mastectomy
Autorzy:
Ciechanowska, Karolina
Krajewska, Karolina
Antczak-Komoterska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1029746.pdf
Data publikacji:
2018
Wydawca:
Państwowa Uczelnia Zawodowa we Włocławku
Tematy:
breast cancer
mastectomy
prevention
Opis:
Introduction. Breast cancer is one of the most frequently reported cases of cancer among women. Prevention and a healthy lifestyle offer a significant opportunity to avoid mastectomy which is the most radical form of treatment. The aim. The aim of the work is to present the review of literature on health promotion, prevention and the way women cope with everyday life after surgical removal of the breast. Overview. A number of factors contribute to the development of breast cancer. A crucial aspect of prevention is the enhancement of pro-health behaviors among women, which helps to reduce the risk of disease. Mastectomy is one of many methods of treatment for breast cancer. The quality of life of women after mastectomy is significantly affected. The most common problem is the lack of self-acceptance, a changed body image. Conclusions. Statistics show a substantial increase in the burden of cancer and the number of deaths from breast cancer. The results of the research among post-mastectomy women indicate huge changes in the mental and physical sphere of their functioning.
Wstęp. Rak piersi jest jednym z najczęściej odnotowywanych przypadków nowotworów wśród kobiet. Profilaktyka oraz zdrowy styl życia stwarzają szansę na unikanie radykalnej formy leczenia jaką jest mastektomia. Cel. Celem pracy jest przegląd piśmiennictwa obejmujący zakres promocji zdrowia, profilaktyki oraz sposobu radzenia sobie kobiet po chirurgicznym usunięciu piersi. Przegląd. Szereg czynników sprzyja rozwojowi raka piersi. Bardzo istotnym aspektem profilaktyki jest potęgowanie zachowań prozdrowotnych wśród kobiet, co sprzyja zmniejszeniu ryzyka wystąpienia choroby. Mastektomia jest jedną z wielu metod leczenia raka piersi. Jakość życia kobiet po mastektomii ulega znacznej zmianie. Najczęściej występującym problemem jest brak akceptacji własnej osoby, zmienionego obrazu ciała. Wnioski. Dane statystyczne wskazują na przyrost liczby zachorowań i zgonów z powodu raka piersi. Wyniki badań wśród kobiet po mastektomii wskazują na ogromne zmiany w sferze psychicznej oraz fizycznej ich funkcjonowania.
Źródło:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2018, 3, 4; 91-99
2451-1846
Pojawia się w:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polyphenol-rich diet is associated with decreased level of inflammatory biomarkers in breast cancer patients
Autorzy:
Sut, A.
Pytel, M.
Zadrozny, M.
Golanski, J.
Rozalski, M.
Powiązania:
https://bibliotekanauki.pl/articles/871900.pdf
Data publikacji:
2019
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Opis:
Background. The study investigated the relationship between dietary intake of polyphenols and inflammatory markers: CRP, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), medium platelet volume/lymphocyte ratio (MPVRL), in newly-diagnosed breast cancer patients. Objectives. The aim of this work was to verify whether diet rich in plant polyphenols affects inflammatory markers in breast cancer patients. Materials and methods. 78 patients (55.3±14.5 years) treated surgically for breast cancer were studied. A modified FFQ and authorial worksheet based on the Phenol Explorer database was used to measure the amount of plant polyphenols in a diet. Basing on the median of polyphenols intake (1780 mg/day), the group was divided into two subgroups: low- and high- dietary intake of polyphenols (LDIP and HDIP, respectively). Plasma CRP level was measured and NLR, PLR and MPVLR were calculated using results from peripheral blood morphology. Results. LDIP was associated with significantly higher CRP (elevated in 34.5% LDIP patients vs. 8.3% HDIP, p<0.003), NLR (elevated in 46.2% LDIP patients vs. 25.6% HDIP, p<0.006) and PLR level (elevated in 25.6% LDIP patients vs. 12.8% HDIP, p<0.03). MPVLR was not significantly different between both the subgroups. Conclusion. High dietary intake of polyphenols remarkably reduced process of inflammation in breast cancer patients, which has important clinical implications. The study demonstrated also an usefulness of simple, cheap and commonly available biomarkers for monitoring anti-inflammatory effects of diet.
Wprowadzenie. Badano zależność pomiędzy pobraniem polifenoli wraz z dietą a poziomem markerów stanu zapalnego: CRP, wskaźnika neutrofile/limfocyty (NLR), płytki/limfocyty (PLR) oraz średnia objętość płytek/limfocyty (MPVLR) wśród nowo zdiagnozowanych pacjentek z rakiem piersi. Cel. Celem pracy było zweryfikowanie czy dieta bogata w polifenole roślinne wpływa na parametry stanu zapalnego u pacjentek z rakiem piersi. Materiały i metody. Do badania włączono 78 pacjentek (55.3±14.5 lat) klasyfikowanych do leczenia chirurgicznego raka piersi. Do oszacowania zawartości polifenoli w diecie użyto zmodyfikowanego zwalidowanego FFQ i autorskiego arkusza opartego na bazie Phenol Explorer. Po wyliczeniu median spożycia polifenoli (1780mg/dobę), podzielono pacjentki na dwie grupy: niskiego i wysokiego spożycia polifenoli (odpowiednio LDIP I HDIP). Zmierzono stężenie CRP oraz na podstawie wyników morfologii krwi obwodowej wyliczono wskaźniki NLR, PLR oraz MPVLR. Wyniki. W grupie z niższym pobraniem polifenoli zaobserwowano znacząco wyższe wartości CRP (podwyższone u 34.5% vs grupa wysokiego spożycia 8.3%, p<0.003), NLR (podwyższone w 46.2% vs 25.6%, p<0.006) oraz poziom PLR (podwyższone u 25.6% vs 12.8%, p<0.03). Wartości MPVLR nie różniły się istotnie pomiędzy podgrupami. Wnioski. Wysokie spożycie polifenoli znacząco redukowało proces zapalny u pacjentek z rakiem piersi, co ma znaczące implikacje kliniczne. Badanie przedstawiło również użyteczność prostych, tanich i powszechnie dostępnych biomarkerów do monitorowania przeciwzapalnego wpływu diety.
Źródło:
Roczniki Państwowego Zakładu Higieny; 2019, 70, 2
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Liposomal doxorubicin in first line metastatic HER-2-positive breast cancer for prevention the cardiotoxicity
Autorzy:
Chmielowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1065040.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
HER-2 overexpression
cardiotoxicity
liposomal doxorubicin
Opis:
We describe a 62 year old female with metastatic HER-2-positive breast cancer, and with independent cardiovascular comorbidities. She was earlier treated with J131 therapy due to thyroid toxicity. She developed grade 2 mitral and tricuspid valvular insufficiency as a result of uncontrolled hypertension. In 2013, the patient was diagnosed with luminal B2 breast cancer with liver and bone metastases, and a large infiltration of the left breast together with the surrounding soft tissue. She was treated with liposomal doxorubicin and cyclophosphamide, with the dose of anthracycline slightly reduced to 50 mg/m2 because of the elevated liver enzymes. She was in complete remission during treatment, without any cardiac or hematologic toxicity. The treatment was prolonged to eight cycles until the liver tests returned to normal. The cumulative dose of liposomal doxorubicin amounted to 400 mg/m2 (with the maximum recommended dose of 600 mg/m2). We decided to administer the liposomal form of doxorubicin, which is less cardiotoxic than conventional doxorubicin, as first-line treatment in order to prevent cardiotoxicity in a patient who is a candidate for another cardiotoxic therapy involving trastuzumab in the future. The patient’s disease progressed 10 months following the completion of first-line therapy. There are no cardiologic contraindications to trastuzumab and there are no signs of liposomal doxorubicin-related cardiotoxicity or deterioration of the valvular insufficiency.
Źródło:
OncoReview; 2015, 5, 1; A11-A15
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nowe możliwości leczenia uogólnionego raka piersi
New possibilities of therapy for advanced, metastatic breast cancer
Autorzy:
Kuc-Rajca, Małgorzata
Walaszkowska-Czyż, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1066145.pdf
Data publikacji:
2013
Wydawca:
Medical Education
Tematy:
ewerolimus
inhibitor mTOR
pertuzumab
rak piersi
trastuzumab
Opis:
Despite improving screening methods, diagnosis of early breast cancers, new therapies the prognosis in breast cancer remains poor. Advanced, metastatic breast cancer is an incurable, persistent disease. Hormonotherapy is the main treatment of receptor positive breast cancer patients. Till now in case of hormone resistant disease chemotherapy was the only choice nowadays there is possibility to use combination of endocrine and targeted therapy, the mTOR inhibitor everolimus. In HER2 receptor positive breast cancer therapy with trasuzumab improved treatment results. Despite many new treatment methods there is still need for new therapies which could improve the patients outcome.
Mimo udoskonalania metod badań przesiewowych, wczesnego wykrywania raka piersi i nowych terapii rokowanie w raku piersi pozostaje złe. Zaawansowany, uogólniony rak piersi jest chorobą przewlekłą, nieuleczalną. Podstawową metodą leczenia systemowego nowotworów dodatnich receptorowo jest hormonoterapia. Do niedawna w przypadku oporności metodą z wyboru pozostawała chemioterapia, obecnie możliwe jest zastosowanie skojarzenia leczenia hormonalnego z leczeniem celowanym ewerolimusem – inhibitorem mTOR. W rakach z nadekspresją receptora HER2 rokowanie pacjentek zmieniło wprowadzenie do leczenia trastuzumabu. Mimo dostępności wielu metod leczenia nadal poszukuje się nowych, które poprawią wyniki leczenia.
Źródło:
OncoReview; 2013, 3, 1; 59-62
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nuclear medicine diagnostic tools for early detection of myocardial damage in treated breast cancer patients
Autorzy:
Tzonevska, Antonia
Tzvetkov, Krasimir
Atanasova, Mariana
Chakarova, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1065669.pdf
Data publikacji:
2014
Wydawca:
Medical Education
Tematy:
GSPECT-CT
myocardial scintigraphy
treatment-induced cardiotoxicity
Opis:
The most severe side effect in treated patients with breast cancer is treatment-induced cardiotoxicity, leading to chronic heart failure or CAD, and worsening the patient’s quality of life. The early detection and medical protection is needed to prevent it. The aim of the study was to detect early signs of cardiotoxicity. Material and methods: 148 breast cancer patients were included in the study: 64 after combined treatment (chemo- and radiotherapy), 56 patients after radiotherapy, 28 patients after chemotherapy. We performed myocardial scintigraphy (GSPECT-CT), EchoCG, proBNP measurement. Results: The analysis of the results present early signs of cardiotoxicity in 46% of investigated patients. Exclusion criteria were: patients with cardiac symptoms, pathologic ECG and LVEF. EchoCG results indicated normal systolic function in all (n = 120) patients (mean LVEF 64%), in 79 (66%) patients – normal diastolic function, in 41 (34%) patients diastolic dysfunction was found. Myocardial scintigraphy: normal systolic function was found in all patients (mean LVEF 68%), no segmental dysfunction, diastolic dysfunction had 47 (32%) patients. Hypoperfused myocardial segments were found in 39 (26%) patients. Normal myocardial perfusion had 125 (84%) patients. ProBNP: normal proBNP values were measured in 64 patients, increased values – in 7 (9%) patients. Conclusion: The results indicated earlier detection of signs of cardiotoxicity in comparison to the routine diagnostic methods. Applying myocardial GSPECT-CT, we can detect early signs of myocardial damage before positive results from routine tests for cardiotoxicity and before severe morphologic myocardial damage.
Źródło:
OncoReview; 2014, 4, 3; A93-99
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Retrospective analysis of local recurrence rate in breast cancer patients treated at the department of surgical oncology in Łódź between 2009 and 2013
Autorzy:
Morawiec, Jan
Dziki, Adam
Morawiec, Zbigniew
Kołacińska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1395718.pdf
Data publikacji:
2014-02-01
Wydawca:
Index Copernicus International
Tematy:
breast cancer
local recurrence
Opis:
The aim of the study was to analyze clinicopathological features in breast cancer patients with local recurrence (LR). Material and methods. A retrospective analysis of database of breast cancer patients operated on in the Department of Surgical Oncology in Łódź from 2 January 2009 to 30 June 2013, identified 1080 women with primary breast cancer and 11 patients with LR. Results. LR rate was 0.23% per year. True recurrence (TR) occurred more frequently in patients with luminal B molecular subtype, in HER-2 positive and in triple-negative subgroups. In one patient with luminal -A subtype new primary (triple negative) occurred. TR were noted predominantly in patients with axillary lymph nodes metastases and with luminal B subtype who did not receive adjuvant chemotherapy but were given only endocrine therapy. LR were observed more frequently in patients who did not receive adjuvant radiotherapy or this treatment was delayed. Minimal surgical margins in postoperative specimens measured by pathologist were 4-25 mm, mean 9.5 mm. Conclusions. The LR rate in patients operated on breast cancer in the Department of Surgical Oncology between 2009 and 2013 was low. TR was diagnosed in patients with non- luminal A breast cancer despite wide surgical margins, especially if the patients did not receive optimal adjuvant systemic treatment or radiotherapy was delayed or omitted. Complete cancer excision followed by an immediate implementation of optimal adjuvant treatment seems to be crucial especially in patients with poor tumor biology.
Źródło:
Polish Journal of Surgery; 2014, 86, 2; 77-81
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cardiotoxicity in breast cancer patients after radiotherapy – modern methods of minimizing the dose to the heart and dilemmas of choosing critical cardiac structures for monitoring dose distribution
Autorzy:
Pudełek, Katarzyna
Pudełek, Jacek
Nawrocki, Sergiusz
Powiązania:
https://bibliotekanauki.pl/articles/1064839.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
breast cancer
cardiotoxicity
radiotherapy
Opis:
Radiotherapy in breast cancer patients is an important component of multidisciplinary treatment. It reduces the risk of local recurrence and mortality from breast cancer. However, it can lead to secondary effects due to the presence of the heart within the irradiation field. Adjuvant radiation therapy for breast cancer increases the risk of coronary artery disease, myocardial infarction and cardiovascular death. It is important to determine the optimal treatment to minimize cardiotoxicity. Modern radiotherapy techniques may reduce radiation-induced cardiac toxicity, but it is necessary to determine the most sensitive structures within the heart, tolerance doses, and methods for early detection and monitoring of adverse effects.
Źródło:
OncoReview; 2016, 6, 3; A113-117
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
HER2-positive breast cancer -a vailable anti-HER2 therapies and new agents under investigation
Autorzy:
Zielinska, M.
Zarankiewicz, N.
Kosz, K.
Kuchnicka, A.
Cisel, B.
Powiązania:
https://bibliotekanauki.pl/articles/2097840.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
breast cancer
targeted therapies
HER2-positive breast cancer
HER2-targeting treatment
anti-HER2 drugs
Opis:
Introduction and objectives. Breast cancer (BC) is the most common malignancy and the leading cause of cancer death among women. About 15–20% of all BCs are HER2-positive. Proper assessment of HER2 status is crucial to choose appropriate treatment. The review summarizes data on anti-HER2 drugs used to treat HER2-positive BC and provides basic information on new agents under investigation. Brief description of the state of knowledge. Specific HER2-targeting drugs are available or are being evaluated in clinical trials. Anti-HER2 agents include: monoclonal antibodies, tyrosine kinase inhibitors, antibody-drug conjugates, bispecific antibodies, PI3K/AKT/mTOR inhibitors and heat shock protein 90 inhibitors, HER2-targeting vaccines and CDK4/6 inhibitors. The advent of anti-HER2 therapies increased the time of progression free survival and overall survival in BC patients. Results. Final analysis of the CLEOPATRA trial shows that the combination of trastuzumab, pertuzumab and taxane significantly improved outcomes in metastatic HER2-positive BC and it is currently preferred first-line treatment. The recommended second-line treatment is based on trastuzumab emtansine or on the combination of lapatinib and capecitabine. Some promising agents such as margetuximab or trastuzumab deruxtecan are still under investigation. Conclusions. Anti-HER2 directed treatment undoubtedly improves outcomes among patients with HER2-positive BC. Access to drugs such as trastuzumab, pertuzumab, lapatinib and T-DM1 improves prognosis even in patients with advanced disease. Further studies and clinical trials on novel anti-HER2 therapies are required. Nevertheless, BC treatment is becoming more effective and, hopefully, one day it may be possible to cure patients even with metastases.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2020, 14, 2; 44-48
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Connecting the dots: understanding the relationship between religiosity, psychological resilience and depression in breast cancer patients
Autorzy:
Fradelos, E.C.
Powiązania:
https://bibliotekanauki.pl/articles/1918864.pdf
Data publikacji:
2019-08-26
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Religiosity
breast cancer
depression
psychological resilience
Opis:
Introduction: Death anxiety, fear of abundance, isolation, stigma of the disease and medication side effects are among the most common sources of anxiety and depression in patients with breast cancer. Purpose: To examine the possible relationship between religiosity, psychological resilience and depression on breast cancer patients. Materials and methods: A cross-sectional design was employed in this study which 152 breast cancer patients participated. Data were collected with the following instruments: Patient Health Questionnaire-2-item scale, Connor-Davidson Resilience Scale 25 and Centrality of Religiosity Scale and a special designed sheet reporting social, demographic and clinical characteristics. Statistical analyses were conducted with the Statistical Package for the Social Science V25. Descriptive statistics such means, and frequencies were calculated and inferential statistics such correlation test, simple and multiple regression analysis were applied. Results: Approximately 1 in 3 patients suffered symptoms of depression while they were reporting moderate religiosity and resilience values. Based on the four-step mediation analysis religiosity was strongly associated with psychological resilience but it was not found to affect directly either depression, but psychological resilience can be a mediator between religiosity and depression. Conclusion: This study supports the notion thatreligiosity and spirituality can have a beneficial influence on health outcomes.
Źródło:
Progress in Health Sciences; 2019, 1; 98-104
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-100 z 304

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