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Tytuł:
Heterogenność raka piersi – sprawozdanie z IMPAKT Breast Cancer Conference
Breast cancer heterogeneity – report from IMPAKT Breast Cancer Conference
Autorzy:
Pogoda, Katarzyna
Powiązania:
https://bibliotekanauki.pl/articles/1066065.pdf
Data publikacji:
2013
Wydawca:
Medical Education
Tematy:
HER2
biopsja przerzutu
heterogenność
mTOR
profile molekularne
Opis:
On 2–4 May 2013, in Brussels took place the 5th IMPAKT conference on translational research in breast cancer. The most important issue raised during the conference was the phenomenon of breast cancer heterogeneity, both inter- and intratumour. Heterogeneity of breast cancer was confirmed at the molecular level, showing the differences in the frequency of genetic aberrations (typically PIK3CA, TP53 and ARID1A) in patients with hormone-dependent advanced breast cancer (BOLERO-2 trial). The results of genetic tests were also presented, which showed that in order to reduce the impact of heterogeneity within the tumor, 3 biopsies should be performed from each breast cancer. The most common disorders of PI3K/mTOR pathway were analyzed depending on the molecular type of breast cancer. However, an attempt to determine by immunohistochemistry biomarkers predicting response to combination therapy with everolimus and trastuzumab failed. The results of two studies, which analyzed the value of molecular tests in predicting late recurrence of breast cancer (in 5–10 years after diagnosis), were presented – the best results were achieved with PAM50 and Breast Cancer Index. The latest discoveries in molecular imaging were also presented – it allows for early assessment of treatment efficacy.
W dniach 2–4 maja 2013 r. w Brukseli odbyła się 5. konferencja IMPAKT poświęcona tematyce badań podstawowych nad rakiem piersi. Najważniejszym zagadnieniem poruszanym podczas konferencji było zjawisko heterogenności raka piersi, występujące zarówno między guzami, jak i w obrębie jednego guza. Potwierdzono heterogenność raka piersi na poziomie molekularnym, wykazując różnice w częstości aberracji genetycznych (najczęściej w obrębie PIK3CA, TP53 i ARID1A) w guzach u chorych na hormonozależnego, zaawansowanego raka piersi (badanie BOLERO-2). Przedstawiono również wyniki badań genetycznych, które wykazały, że aby ograniczyć wpływ heterogenności w obrębie guza, należy wykonywać 3 biopsje z każdego raka piersi. Zbadano najczęstsze zaburzenia szlaku PI3K/mTOR w zależności od typu molekularnego raka piersi. Natomiast próba określenia za pomocą immunohistochemii biomarkerów odpowiedzi na terapię skojarzoną ewerolimusem z trastuzumabem nie powiodła się. Zaprezentowano wyniki dwóch prac naukowych, w których analizowano wartość testów molekularnych w predykcji późnego nawrotu raka piersi (5–10 lat od rozpoznania) – najlepsze wyniki osiągnięto w przypadku PAM50 i Breast Cancer Index. Poza tym przedstawiono najnowsze doniesienia w zakresie obrazowania molekularnego pozwalającego na wczesną ocenę skuteczności stosowanej terapii.
Źródło:
OncoReview; 2013, 3, 2; 110-114
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fertility and breast cancer
Autorzy:
Kufel-Grabowska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1064776.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
breast cancer during pregnancy
breast cancer in young women
fertility
fertility preservation strategies
Opis:
Breast cancer is the most common cancer among females worldwide. The mean age of breast cancer patients is > 60 yrs old, and it is seldom found in women < 40 yrs old (6.5%) and in very young women < 35 yrs old (0.6%). In young females, fertility and all its aspects are an additional therapeutic challenge. Before initiating treatment, the oncologist should offer effective contraception to be applied throughout the therapy, bearing in mind that fertility preservation is of utmost importance. When it comes to breast cancer in pregnancy, the attending physician should use a therapy which is safe for both the mother and the foetus. Chemotherapy, radiotherapy, hormonal therapy and immunotherapy can, to a lesser or greater degree, damage the ovarian function resulting in amenorrhea in women < 50 yrs (33–76%). However, owing to fertility preservation strategies, more and more pregnancies are successful, even in breast cancer survivors.
Źródło:
OncoReview; 2016, 6, 4; A157-161
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Breast Cancer in Art Painting
Autorzy:
Forma, Ewa
Bernaciak, Magdalena
Bryś, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/764935.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
breast cancer
art paintings
famous painters
Opis:
Breast cancer is an emotive cancer. It is a disease that affects a visible sexual organ and it is the commonest single cause of death of women between 40 and 60 years of age. Nevertheless, this type of cancer was infrequently depicted in art paintings. In this article the themes from the breast cancer in famous art paintings are discussed.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2010, 6; 61-68
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changing paradigms in breast cancer treatment
Autorzy:
Ali, Shan
Buczek, Dagmara
Jassem, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1196786.pdf
Data publikacji:
2020-12-03
Wydawca:
Gdański Uniwersytet Medyczny
Tematy:
breast cancer
sentinel node biopsy
breast-conserving surgery
targeted therapy
molecular profiles
Opis:
In only the past century, the landscape of breast cancer treatment has completely changed. The Halstedian hypothesis of the “contiguous spread” of breast cancer has been replaced by a consideration of its systemic nature. Today, patients with early-stage breast cancer are managed with breast-conserving therapy, which is as effective as mastectomy. Sentinel lymph node biopsy has largely replaced axillary lymph node dissection. Post-operative radiotherapy, chemotherapy and endocrine therapy have increased survival. Pre-operative cytotoxic therapy allows for less extensive surgery and for a curative resection even in more advanced stages. Rapid progress in molecular oncology revealed a large heterogeneity of breast cancer, resulting in a more personalized approach. Targeted therapies directed against epidermal growth factor receptor type 2 (HER2) have improved survival in HER2-positive breast cancer, which was once a poor-prognosis entity. Multi-gene prognostic signatures better predict prognosis and allow many patients to avoid chemotherapy. Personalized treatment has resulted in decreased toxicity and an improved quality of life. Within the past decades, breast cancer has become a good-prognosis malignancy with a five-year survival in the range of 80-85%. Future development of personalized medicine may further refine treatment based on the tumor’s molecular features.
Źródło:
European Journal of Translational and Clinical Medicine; 2020, 3, 2; 53-63
2657-3148
2657-3156
Pojawia się w:
European Journal of Translational and Clinical Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multimodal Ultrasonic Imaging for Breast Cancer Detection
Autorzy:
Camacho, J.
Medina, L.
Cruza, J. F.
Moreno, J. M.
Fritsch, C.
Powiązania:
https://bibliotekanauki.pl/articles/176695.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
ultrasound imaging
ultrasound tomography
breast cancer
Opis:
Ultrasound is used for breast cancer detection as a technique complementary to mammography, the standard screening method. Current practice is based on reflectivity images obtained with conventional instruments by an operator who positions the ultrasonic transducer by hand over the patient’s body. It is a non-ionizing radiation, pain-free and not expensive technique that provides a higher contrast than mammography to discriminate among fluid-filled cysts and solid masses, especially for dense breast tissue. However, results are quite dependent on the operator’s skills, images are difficult to reproduce, and state-of-the-art instruments have a limited resolution and contrast to show micro-calcifications and to discriminate between lesions and the surrounding tissue. In spite of their advantages, these factors have precluded the use of ultrasound for screening. This work approaches the ultrasound-based early detection of breast cancer with a different concept. A ring array with many elements to cover 360. around a hanging breast allows obtaining repeatable and operator-independent coronal slice images. Such an arrangement is well suited for multi-modal imaging that includes reflectivity, compounded, tomography, and phase coherence images for increased specificity in breast cancer detection. Preliminary work carried out with a mechanical emulation of the ring array and a standard breast phantom shows a high resolution and contrast, with an artifact-free capability provided by phase coherence processing.
Źródło:
Archives of Acoustics; 2012, 37, 3; 253-260
0137-5075
Pojawia się w:
Archives of Acoustics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Web–based framework for breast cancer classification
Autorzy:
Bruździński, T.
Krzyżak, A.
Fevens, T.
Jeleń, Ł.
Powiązania:
https://bibliotekanauki.pl/articles/91866.pdf
Data publikacji:
2014
Wydawca:
Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
Tematy:
breast cancer
classification
cytological image
aspiration biopsy
feature vector
classifier
multilayer perceptron
segmentation algorithm
Opis:
The aim of this work is to create a web-based system that will assist its users in the cancer diagnosis process by means of automatic classification of cytological images obtained during fine needle aspiration biopsy. This paper contains a description of the study on the quality of the various algorithms used for the segmentation and classification of breast cancer malignancy. The object of the study is to classify the degree of malignancy of breast cancer cases from fine needle aspiration biopsy images into one of the two classes of malignancy, high or intermediate. For that purpose we have compared 3 segmentation methods: k-means, fuzzy c-means and watershed, and based on these segmentations we have constructed a 25–element feature vector. The feature vector was introduced as an input to 8 classifiers and their accuracy was checked. The results show that the highest classification accuracy of 89.02 % was recorded for the multilayer perceptron. Fuzzy c–means proved to be the most accurate segmentation algorithm, but at the same time it is the most computationally intensive among the three studied segmentation methods.
Źródło:
Journal of Artificial Intelligence and Soft Computing Research; 2014, 4, 2; 149-162
2083-2567
2449-6499
Pojawia się w:
Journal of Artificial Intelligence and Soft Computing Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Epidemiology of breast cancer in Podkapackie voivodship
Autorzy:
Gustalik, Joanna
Bartusik-Aebisher, Dorota
Ostańska, Elżbieta
Przyczyna, Piotr
Osuchowski, Michał
Aebisher, David
Galiniak, Sabina
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454657.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
breast cancer
statistics
epidemiology
podkarpackie voivodship
Opis:
Introduction. Breast cancer is the second most prevalent reason for cancer deaths after lung cancer. Incidence rates have increased worldwide. Aim. To present epidemiology of breast cancer in Podkapackie voivodship. Material and methods. This analysis was performed using a systematic literature search. Results. In the Podkarpackie voivodship up until 2014, the incidence rate of female breast cancer was rising and in 2015 it dropped by 68 cases. Even though the survival rate is increasing, it is still one of the leading causes of cancer deaths placing second after lung cancer. Conclusion. Mortality rate, unfortunately, rose gradually. This shows that even though there is a National Health Program aiming at breast cancer awareness and prevention, it is still not enough to reduce the number of breast cancer deaths.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 242-245
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Primary and secondary prevention of breast cancer
Autorzy:
Kolak, Agnieszka
Kamińska, Marzena
Sygit, Katarzyna
Budny, Agnieszka
Surdyka, Dariusz
Kukiełka-Budny, Bożena
Burdan, Franciszek
Powiązania:
https://bibliotekanauki.pl/articles/987031.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
breast cancer
primary and secondary prevention
risk factors
life style
mammography
modern diagnostics methods
Opis:
Introduction. Breast cancer is the most common cancer among women and is the second cancer frequently occurring worldwide of newly-diagnosed cancers. There is much evidence showing the influence of life style and environmental factors on the development of mammary gland cancer (high-fat diet, alcohol consumption, lack of physical exercise), the elimination of which (primary prevention) may contribute to a decrease in morbidity and mortality. Secondary prevention, comprising diagnostic tests (e.g. mammography, ultrasonography, magnetic resonance imaging, breast self-examination, as well as modern and more precise imaging methods) help the early detection of tumours or lesions predisposing to tumours. Objective. The aim of this study paper is to review current knowledge and reports regarding primary and secondary prevention of breast cancer. State of knowledge. It is estimated that nearly 70% of malign tumours are caused by environmental factors, whereas in breast cancer this percentage reaches 90–95%. There are national programmes established in many countries to fight cancer, where both types of prevention are stressed as serving to decrease morbidity and mortality due to cancers. Conclusions. Cancer prevention is currently playing a key role in the fight against the disease. Behaviour modification, as well as greater awareness among women regarding breast cancer, may significantly contribute towards reducing the incidence of this cancer. Another important aspect is the number of women undergoing diagnostic tests, which still remains at an unsatisfactory level.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Neoadjuvant therapy in breast cancer – objectives and tasks
Autorzy:
Ostańska, Elżbieta
Bartusik-Aebisher, Dorota
Aebisher, David
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454710.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
neoadjuvant therapy (NCT)
breast cancer (BC)
triple negative breast cancer (TNBC)
Opis:
Introduction. Neoadiuvant therapy (NCT) in the treatment of breast cancer is employed for patients with early stage disease or with inoperable disease. NCT can decrease the tumor volume. It can facilitate breast conservation therapy. Response to NCT is a strong predictor of outcome breast cancer (BC). Direct target therapies has markedly improved the result of treatment BC. Aim. Therapy for breast cancer continues to improve. The importance of tumor burden on local control rates will be in the future. Material and methods. This analysis was performed using a systematic literature search. Results. The latest scientific reports give hope for greater safety and a better life for patients based on optimized and effective therapy. Conclusion. Currently, improving the effectiveness of breast cancer treatment is mainly related to the optimal use of classic therapeutic strategies. New classes of substances have been approved for treatment or are in advanced stages of clinical development.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 153-156
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Role of nurse in the breast cancer education
Autorzy:
Cetlova, Lada
Dvorakova, Vlasta
Powiązania:
https://bibliotekanauki.pl/articles/2141042.pdf
Data publikacji:
2011
Wydawca:
Instytut Studiów Międzynarodowych i Edukacji Humanum
Tematy:
education
breast cancer
patient
nurse
Opis:
Incidence of female breast cancer in our population remains very high and the incidence increase every year. Breast cancer and following demanding oncological treatment extensively influence life of female patients. It intervene biological, psychical and social life of patient. Objective of our research was to check how women are informed about preventive precautions and how they are following them. Our research sample were randomly selected women of all age groups. Our results showed that it is necessary to increase activity in the area of education, increase personal responsibility in area of breasts self-examination and better inform about the influence of obesity to breast cancer incidence. Considering our previous experience in health care we were surprised that the role of nurse in education process is very low. We think that general nurses have enough opportunities to use daily contacts with patients to inform and lecture them.
Źródło:
Humanum. Międzynarodowe Studia Społeczno-Humanistyczne; 2011, 2(7); 315-320
1898-8431
Pojawia się w:
Humanum. Międzynarodowe Studia Społeczno-Humanistyczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stomach metastasis from breast cancer-mimicking linitis plastica
Autorzy:
Czerko, Katarzyna
Ostrowski, Michał
Bodnar, Lubomir
Powiązania:
https://bibliotekanauki.pl/articles/3200732.pdf
Data publikacji:
2022-09-30
Wydawca:
Medical Education
Tematy:
breast cancer
gastric metastases
Opis:
We report a rare case of metastatic gastric cancer from invasive carcinoma of the breast (BC) as the first symptom of disease-mimicking primary gastric linitis plastica.
Źródło:
OncoReview; 2022, 12, 3; 65-67
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Off-label drug use in breast cancer therapy
Autorzy:
Jankowski, Tomasz
Urbaniak, Monika
Powiązania:
https://bibliotekanauki.pl/articles/773466.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
breast cancer
capecitabine
chemotherapy
liposomal doxorubicin
metronomic vinorelbine
off-label
Opis:
Breast cancer is one of the most common malignancies across the world, including Poland. Chemotherapy plays an important part in the treatment of the disease. Most of the available chemotherapy drugs and regimens have undergone randomized clinical studies and have been registered for that specific indication. However, a number of drugs are used in an off-label manner, i.e. outside the officially approved product specifications. The paper discusses the use of several off-label therapies in breast cancer in order to demonstrate that such treatment may be well-grounded and indeed turns out beneficial in many cases. It describes the use of liposomal doxorubicin in pre- and post-operative treatment, capecitabine for incomplete efficacy of preoperative treatment, and the administration of metronomic vinorelbine. Moreover, the paper is aimed at demonstrating the legal basis and the principles of marketing authorization of off-label drug use.
Źródło:
OncoReview; 2017, 7, 2; 83-87
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acceptance of illness by women with breast cancer
Autorzy:
Cipora, E.
Konieczny, M.
Sobieszczański, J.
Powiązania:
https://bibliotekanauki.pl/articles/2081561.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
breast cancer
demographic factors
AIS Scale
acceptance of illness
Opis:
Introduction. Despite great progress in the diagnostics and treatment, breast cancer still remains the most frequently diagnosed malignant cancer in women. The outcomes of cancer treatment depend, to a considerable extent, on the degree of acceptance of the illness. The objective of the study was determination of the level of acceptance of the disease among the examined women with breast cancer. Materials and method. The study covered a group of 231 women who received treatment for breast cancer in the Rev. Bronislaw Markiewicz Subcarpathian Oncology Centre in Brzozow, south-eastern Poland, and conducted by the method of a diagnostic survey, using an author constructed questionnaire and the standard Acceptance of Illness Scale, adapted by Z. Juczyński. Statistical analyses were performed using the software IBM SPSS v. 21.0.0.1. The p values p≤0.05 were considered statistically significant. Results. The mean level of acceptance of the illness in the examined group of women was 26.53 (SD = 7.71; Me = 26). The largest number of respondents (50.6%) obtained scores within the range of 20–29, according to the AIS Scale. From among the adopted variables, the level of acceptance of the illness significantly varied according to age and occupational activity. However, no such differences were confirmed according to the place of residence, marital status, education level, or the type of occupation performed. Conclusions. In the examined group of women, a mediocre level of acceptance of cancer was observed. The respondents’ age and occupational situation exerted a significant effect on the level of acceptance of the illness. The results of the study should be considered as satisfactory because the number of women with a high level of acceptance of breast cancer was more than twice as high as those ones with a low acceptance of the disease.
Źródło:
Annals of Agricultural and Environmental Medicine; 2018, 25, 1; 167-171
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Feature selection for breast cancer malignancy classification problem
Autorzy:
Filipczuk, P.
Kowal, M.
Marciniak, A.
Powiązania:
https://bibliotekanauki.pl/articles/333614.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:
wybór funkcji
klasyfikacja
rak piersi
feature selection
classification
breast cancer
Opis:
The paper provides a preview of some work in progress on the computer system to support breast cancer diagnosis. Diagnosis approach is based on microscope images of the FNB (Fine Needle Biopsy) and assumes distinguishing malignant from benign cases. Studies conducted focus on two different problems, the first concern the extraction of morphometric parameters of nuclei present in cytological images and the other concentrate on breast cancer nature classification using selected features. Studies in both areas are conducted in parallel. This work is devoted to the problem of feature selection from the set of determined features in order to maximize the accuracy of classification. Morphometric features are derived directly from a digital scans of breast fine needle biopsy slides and are computed for segmented nuclei. The quality of feature space is measured with four different classification methods. In order to illustrate the effectiveness of the approach, the automatic system of malignancy classification was applied on a set of medical images with promising results.
Źródło:
Journal of Medical Informatics & Technologies; 2010, 15; 193-199
1642-6037
Pojawia się w:
Journal of Medical Informatics & Technologies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rak piersi w ciąży
Breast cancer in pregnancy
Autorzy:
Karczmarek-Borowska, Bożenna
Golon, Kamila
Powiązania:
https://bibliotekanauki.pl/articles/437712.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
nowotwór złośliwy piersi
ciąża
diagnostyka
leczenie
malignant breast cancer
pregnancy
diagnostics
treatment
Opis:
Rak piersi w ciąży to nowotwór rozpoznany w okresie do pierwszego roku po zakończeniu ciąży lub w okresie laktacji. Wpływ ciąży na proces nowotworowy nie jest do końca wyjaśniony. Rozpoznanie choroby opiera się na podstawie badań wykonywanych standardowo jak u kobiet niebędących w ciąży, z wyjątkiem stosowania technik obrazowania promieniowaniem jonizującym oraz rezygnacji z użycia kontrastu. Leczenie nowotworu przebiega podobnie jak u innych pacjentek, lecz zaleca się mastektomię dopiero po ukończeniu pierwszego trymestru ciąży. Nie zaleca się leczenia oszczędzającego z powodu przeciwwskazań do radioterapii uzupełniającej w trakcie trwania ciąży. Na podstawie badań wykazano, że bezpieczne są schematy chemioterapii oparte na antracyklinach oraz cyklofosfamidzie. Inne cytostatyki oraz hormonoterapia są przeciwwskazane z powodu poważnych uszkodzeń płodu. Leczenie wspomagające w postaci leków przeciwwymiotnych, przeciwbólowych jest dopuszczalne, jednak pod pewnymi warunkami. Po zakończeniu ciąży nie jest zalecane karmienie piersią podczas stosowania chemioterapii, leczenia biologicznego oraz hormonoterapii, ponieważ wiele leków przenika do mleka matki. Nie ustalono ostatecznie wpływu ciąży na rokowanie raka piersi. Ponieważ zmiany gruczołu piersiowego podczas ciąży i karmienia traktowane są jako fizjologiczne, zdarza się, że opóźnienie diagnozy sięga nawet 7 miesięcy. Uważa się, że przerwanie ciąży nie poprawia wyników leczenia. Kolejną ciążę można rozważać po około 3 latach od zakończenia leczenia przeciwnowotworowego, po wykluczeniu wznowy choroby oraz przerzutów odległych.
Breast cancer in pregnancy is a neoplasm diagnosed during the first year postpartum or during lactation. Effect of pregnancy on the neoplastic process is not fully understood. The diagnosis is based on the tests performed as in case of non-pregnant women with the exception of the use of ionizing radiation imaging techniques and use of contrast agent. The course of cancer treatment is the same as for other patients, but mastectomy is recommended after the first trimester of pregnancy. Conservative treatment is not recommend due to contraindications for radiotherapy during pregnancy. The studies have demonstrated that chemotherapy regimens based on anthracycline and cyclophosphamide are safe. Other cytotoxic drugs and hormonal therapy are contraindicated because of severe damage to the fetus. Adjunctive therapy in the form of antiemetics, analgesics is permitted, but under certain conditions. Breast-feeding after labour is not recommended during chemotherapy, hormonal therapy and biological therapy, because many drugs are excreted into breast milk. Definite effect of pregnancy on breast cancer prognosis has not been established. Since changes in the mammary gland during pregnancy and lactation are considered as physiological, it happens that diagnosis is delayed even up to 7 months. It is believed that abortion does not improve treatment results. Another pregnancy can be considered only after 3 years when anticancer treatment is finished, cancer relapse and distant metastases are ruled out.
Źródło:
Medical Review; 2014, 2; 182-189
2450-6761
Pojawia się w:
Medical Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Elektrochemioterapia w nowotworach piersi
Electrochemotherapy in breast cancer
Autorzy:
Piechocki, Jacek
Mazur, Sławomir
Nowecki, Zbigniew I.
Powiązania:
https://bibliotekanauki.pl/articles/1030145.pdf
Data publikacji:
2016
Wydawca:
Medical Communications
Tematy:
breast cancer
electrochemotherapy
local recurrence
elektrochemioterapia
rak piersi
wznowa miejscowa
Opis:
Electrochemotherapy is a local therapy method reserved for cases not subject to surgery in advanced surface-localized cancers in the integuments. It may be applied in treating primary skin neoplasms (cancer and melanoma) as well as metastases of other neoplasms to the skin/hypodermis not qualified for another therapy (e.g. local removal or isolated limb perfusion, radiotherapy), regardless of the histological type of the neoplasm. It is a palliative type of treatment, and its objective is to obtain local control over cancerous lesions deteriorating the quality of life of the patients (infections, hemorrhages, limb function limitation). In selected cases, it is possible to obtain a long-term local control (e.g. in advanced, unresectable or qualifying to an extensive procedure on scalp and neck neoplasms and breast cancers with extensive dermis infiltration, reacting poorly to systemic treatment). Especially local breast cancer recurrence, frequently of large area or multiple with tissue infiltration, persisting despite systemic treatment, may be subject to electrochemotherapy. It especially applies to patients with disseminated cancer. In the paper, the authors are summarizing their experience in the application of that method among patients with breast cancer.
Elektrochemioterapia jest metodą terapii miejscowej zarezerwowaną dla przypadków nieoperacyjnych w zaawansowanych nowotworach zlokalizowanych powierzchownie w powłokach ciała. Może być stosowana zarówno w leczeniu pierwotnych nowotworów skóry (raki i czerniaki), jak i przerzutów innych nowotworów do skóry/tkanki podskórnej niekwalifikujących się do innej terapii (np. miejscowego wycięcia lub izolowanej perfuzji kończynowej, radioterapii), niezależnie od typu histologicznego nowotworu. Jest to z założenia leczenie paliatywne, a jego celem jest uzyskanie miejscowej kontroli nad zmianami nowotworowymi pogarszającymi jakość życia chorych (zakażenia, krwawienia, ograniczenie funkcji kończyn). W wybranych przypadkach możliwe jest uzyskanie długotrwałej kontroli miejscowej (np. w zaawansowanych, nieresekcyjnych lub kwalifikujących się do rozległego zabiegu okaleczającego nowotworach skóry głowy i szyi oraz rakach piersi z rozległym naciekiem skóry, słabo reagujących na leczenie systemowe). Zwłaszcza wznowy miejscowe raka piersi, nierzadko o dużej powierzchni lub liczne z naciekiem tkanek, utrzymujące się pomimo leczenia systemowego, mogą być poddane elektrochemioterapii. Dotyczy to szczególnie chorych z rozsianą chorobą nowotworową. W niniejszej pracy autorzy podsumowują własne doświadczenie w zastosowaniu tej metody u chorych na raka piersi.
Źródło:
Current Gynecologic Oncology; 2016, 14, 1; 5-12
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physiotherapy in women after breast cancer treatment – review
Autorzy:
Skutnik, K.
Ustymowicz, W.
Zubrewicz, K.
Zińczuk, J.
Kamińska, D.
Pryczynicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/1918836.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
breast cancer
rehabilitation
mastectomy
physiotherapy
Opis:
Introduction: Breast cancer is the most common malignant tumor in women in the Polish region. Surgery is a basic method of breast cancer treatment. Surgery often carries a lot of unwanted changes as follows: limitation of mobility in the shoulder joint on the operated side, secondary lymphoedema, post mastectomy pain syndrome (PMPS), reduction of muscle strength or disorders in body posture. Therefore, the implementation of physiotherapeutic activities that are designed to prevent and eliminate postoperative complications seems very important. The main aim of this work was to present physiotherapeutic management in women after mastectomy based on the analysis of available literature. The physiotherapeutic process can be divided into three periods: early hospital, early ambulatory and the late ambulatory period. In the first period, active slow exercises, self-support of the upper limb on the operated side and breathing exercises on the thoracic track are used to prevent circulatory disorders, pulmonary complications, and edema. The early ambulatory period includes corrective exercises, general improvement exercises, stretching and learning of automatic massage of the upper limb of the operated side. The last period should be enriched by recreational methods of physical activity such as swimming, cycling or Nordic walking to maintain physical fitness, proper mobility of the shoulder girdle and improve the patient's psychophysical state. It is very important the patient regular continues the rehabilitation program after curing of breast cancer as well. In the case of secondary lymphoedema of the upper limb, comprehensive rehabilitation physiotherapy is used, consisting of manual lymphatic drainage, healing exercises, compression therapy, and skin care. Conclusions: Physiotherapy in women after breast cancer surgery is a complex and long-term process. Physiotherapeutic methods are effective in treating complications after surgery of breast cancer surgery. It is necessary to constantly update the physio-therapy knowledge in women after breast cancer surgery.
Źródło:
Progress in Health Sciences; 2019, 1; 162-168
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ciąża po raku piersi
Pregnancy following breast cancer
Autorzy:
Skrzypczyk-Ostaszewicz, Anna
Jagielska, Beata
Śpiewankiewicz, Beata
Maździarz, Agnieszka
Jaxa-Larecka, Dominika
Powiązania:
https://bibliotekanauki.pl/articles/1030158.pdf
Data publikacji:
2014
Wydawca:
Medical Communications
Tematy:
breast cancer
estrogen receptor
motherhood
pregnancy
recurrence
ciąża
macierzyństwo
rak piersi
receptor estrogenowy
wznowa
Opis:
Many young patients having undergone radical treatment of breast cancer start considering motherhood at some point. The desire to become a mother may appear within a differing period from the completion of cancer therapy, yet it seems that regardless of the period, it is almost inevitably accompanied by major-level anxiety and stress. The decision about whether to become pregnant turns out a very difficult one, due to numerous doubts, uncertainties, and myths that have been commonly accepted concerning the safety of pregnancy for the future mother (i.e. the risk of cancer recurrence while pregnant), the effect of the undergone chemotherapy on the fetus, and breastfeeding-related issues. At the moment the disease is diagnosed, it is extremely rare for a young woman to immediately look out into her future in terms other than mere survival chances. The shock and the fear which are bound with the diagnosis hardly allow to ponder on the woman’s functioning following the treatment, or on her chances to return to all social roles. In some patients the fear of cancer recurrence and of the potential inability to raise the child themselves is so grave, it never allows them to make the decision to become mothers. Psycho-oncologic counseling, therefore, may have crucial impact over the choices made by breast cancer survivors, and not only should it be made available while patients are still tackling the diagnosis and treatment, but well beyond that period, throughout the healing process and follow-up monitoring time. The recent reports from the past few years seem to clarify many doubts and uncertainties, and this paper brings together the most important results of the new research available.
Wiele młodych pacjentek po radykalnym leczeniu raka piersi zaczyna w pewnym momencie rozważać macierzyństwo. Chęć urodzenia dziecka pojawia się w różnym czasie po zakończeniu leczenia, ale wydaje się, że niezależnie od tego okresu niemal zawsze pociąga za sobą lęk i stres. Decyzja o ciąży okazuje się bardzo trudna – wynika to z licznych niejasności i pokutujących mitów dotyczących bezpieczeństwa ciąży dla przyszłej matki (czyli ryzyka nawrotu choroby), wpływu przebytej przez nią chemioterapii na płód i kwestii związanych z karmieniem piersią. W chwili rozpoznania choroby nowotworowej młoda kobieta bardzo rzadko od razu podejmuje temat swojej przyszłości w kontekście innym niż przeżycie. Szok i strach, bezsprzecznie towarzyszące diagnozie, zwykle nie pozwalają na rozważania o przyszłym funkcjonowaniu kobiety po leczeniu i powrocie do wszystkich ról społecznych. U części pacjentek lęk przed wznową raka i ewentualną niemożnością wychowania dziecka jest tak nasilony, że nigdy nie decydują się na macierzyństwo. Poradnictwo psychoonkologiczne może mieć zatem znaczący wpływ na wybory dokonywane przez kobiety po zakończeniu leczenia raka piersi – powinno być dostępne nie tylko podczas zmagania się z diagnozą i leczeniem, lecz także długo później, w okresie zdrowienia i obserwacji po terapii. Doniesienia z kilku ostatnich lat rozwiewają wiele wątpliwości, a niniejsza praca stanowi podsumowanie najważniejszych wyników nowych badań.
Źródło:
Current Gynecologic Oncology; 2014, 12, 1; 25-30
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The presence of HPV DNA in breast cancer
Autorzy:
Kolodziej-Andrejuk, S.
Macielag, P.
Patyra, K.
Mandziuk, S.
Pachnia, D.
Mazurkiewicz, M.
Polz-Dacewicz, M.
Powiązania:
https://bibliotekanauki.pl/articles/3554.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Źródło:
Journal of Pre-Clinical and Clinical Research; 2013, 07, 2
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determinants of women’s behavior in breast cancer prevention
Autorzy:
Nagórska, Małgorzata
Aksamit, Magdalena
Krygowska, Krystyna
Bassara-Nowak, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454727.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
attitudes
breast cancer
knowledge
prophylaxis
Opis:
Introduction. According to statistics, breast cancer is the second leading cause of death in Poland. Progress in treatment and diagnosis gives an opportunity of a quick diagnosis, but women are reluctant to undergo prophylaxis screening. Aim. To identify women’s attitudes about breast cancer prophylaxis. Material and methods. The diagnostic survey was conducted in a group of 200 women. The research tool was the questionnaire developed by the authors. Results. Knowledge about breast cancer and prophylaxis was on an average level. Nearly half of the women surveyed (45.5%) declared that they do not ask for a breast examination while visiting a gynecologist. Only 26.8% of the surveyed women were systematically subjected to preventive examinations for breast cancer, while 18.7% of them performed breast self-examination. Every fifth respondent used invitation for a free mammogram. Conclusion. The women’s knowledge about breast cancer is average, but it does not translate into their attitudes towards the prevention of this cancer. Most women niether perform breast self-examination nor benefit from free prophylaxis programs. Younger respondents most often use the Internet. Education and place of residence do not affect the participation of women in preventive examinations for breast cancer.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 123-130
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Paraneoplastic neurological syndrome in the course of breast cancer
Autorzy:
Ciszewska, Anna
Głogowski, Łukasz
Witkoś, Andrzej
Rusinowska, Zofia
Nowakowska-Zajdel, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1065222.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
breast cancer
paraneoplastic neurological syndromes
stiff person syndrome
Opis:
Paraneoplastic neurological syndromes (PNS) are a group of rarely observed disorders, accompanying about 1% of cancer diseases. They have a typically aggressive course, leading to profound and essentially irreversible disability. The pathogenic cause behind PNS is damage of the nervous system structures as a consequence of the body’s immunological reaction induced by cancer. Onconeural antibodies generated as part of the reaction target the tumour tissues, but also the regular nervous tissue recognized as antigens. Presence of onconeural antibodies reveals a 50–60% sensitivity and 100% specificity in diagnosing PNS. Imaging and laboratory tests have a limited impact on diagnosis. What is crucial is the analysis of clinical systems following Graus’s criteria (elaborated in 2004). In the case presented here, the patient underwent treatment in many neurological departments due to the symptoms of progressive damage of the nervous system. She was eventually diagnosed with the stiff person syndrome related to breast cancer. In spite of the treatment, including an efficacious oncological therapy, the severe neurological deficit resulted in serious motor disability.
Źródło:
OncoReview; 2015, 5, 2; A76-80
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nuclei segmentation for computer-aided diagnosis of breast cancer
Autorzy:
Kowal, M.
Filipczuk, P.
Powiązania:
https://bibliotekanauki.pl/articles/330248.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:
computer aided diagnosis
breast cancer
pattern analysis
fast marching
diagnostyka wspomagana komputerowo
rak piersi
analiza obrazu
Opis:
Breast cancer is the most common cancer among women. The effectiveness of treatment depends on early detection of the disease. Computer-aided diagnosis plays an increasingly important role in this field. Particularly, digital pathology has recently become of interest to a growing number of scientists. This work reports on advances in computer-aided breast cancer diagnosis based on the analysis of cytological images of fine needle biopsies. The task at hand is to classify those as either benign or malignant. We propose a robust segmentation procedure giving satisfactory nuclei separation even when they are densely clustered in the image. Firstly, we determine centers of the nuclei using conditional erosion. The erosion is performed on a binary mask obtained with the use of adaptive thresholding in grayscale and clustering in a color space. Then, we use the multi-label fast marching algorithm initialized with the centers to obtain the final segmentation. A set of 84 features extracted from the nuclei is used in the classification by three different classifiers. The approach was tested on 450 microscopic images of fine needle biopsies obtained from patients of the Regional Hospital in Zielona Góra, Poland. The classification accuracy presented in this paper reaches 100%, which shows that a medical decision support system based on our method would provide accurate diagnostic information.
Źródło:
International Journal of Applied Mathematics and Computer Science; 2014, 24, 1; 19-31
1641-876X
2083-8492
Pojawia się w:
International Journal of Applied Mathematics and Computer Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Severe aortic stenosis in a patient with breast cancer
Autorzy:
Mańczak, Rafał
Wilk, Michał
Walaszkowska-Czyż, Anna
Florczyk, Michał
Szmit, Sebastian
Powiązania:
https://bibliotekanauki.pl/articles/1064894.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
anthracyclines
aortic stenosis
aortic valve replacement
breast cancer
echocardiography
Opis:
We present a case of 68-year-old female with severe symptomatic aortic stenosis and locally advanced breast cancer disqualified from mastectomy due to heart failure and from aortic valve replacement due to malignant neoplasm. The patient received neoadjuvant chemotherapy without anthracyclines. The aortic valve replacement was performed and then mastectomy and lymphadenectomy were made without hemodynamic complications. Adjuvant hormonotherapy was started. During 42 months of follow-up the patient remained free of recurrent cancer disease as well as no progression of heart failure was observed.
Źródło:
OncoReview; 2016, 6, 2; A49-56
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rak piersi współistniejący z ciążą
Breast cancer in pregnancy
Autorzy:
Skrzypczyk-Ostaszewicz, Anna
Jagielska, Beata
Śpiewankiewicz, Beata
Osuch, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1030157.pdf
Data publikacji:
2014
Wydawca:
Medical Communications
Tematy:
breast cancer
chemotherapy
delivery
fetus
hormone therapy
pregnancy
sentinel lymph node
chemioterapia
ciąża
hormonoterapia
poród
płód
rak piersi
węzeł wartowniczy
Opis:
Breast cancer is one of the most common cancers to complicate pregnancy. Up until recently, such diagnosis was almost invariably bound with an abortion with all its possible psychological and ethical consequences for the patient, her family, and treating physicians. Throughout the past few years, the considerable progress in medical knowledge and experience has allowed a radical change in the situation of this very special patient group. These days, women may continue with the pregnancy, yet at the same time be effectively and safely treated, in a very close adherence to standards applied in the treatment of non-pregnant patients. The diagnostics of breast cancer in pregnant patients largely meets the generally accepted standards of detecting and staging the disease, apart from a few exceptions mostly related to fetus safety. The differences concern e.g. the sentinel lymph node evaluation procedure and some imaging methods. Whether the patient qualifies for treatment as well as therapeutic decisions depend on the gestational age and the advancement of the disease, with some treatment procedures imperatively postponed until postpartum. Certain chemotherapy regimens have been proved safe during pregnancy, even though up until recently they were considered toxic and impossible to use (FAC, FEC, taxoids). It has also been shown that, unless obstetric indications for caesarean section exist, in most cases the pregnancy does not need to be terminated prematurely. No oncologic counter-indications for a vaginal delivery exist either. This paper aims to bring together and sum up the body of knowledge arising from the recent publications which have facilitated diagnostic and therapeutic standards to be followed in these infrequent, yet exceedingly complex, clinical situations.
Rak piersi to jeden z najczęstszych nowotworów wikłających ciążę. Jeszcze niedawno takie rozpoznanie wiązało się prawie zawsze z aborcją, ze wszystkimi jej konsekwencjami psychologicznymi i etycznymi dla chorej, jej bliskich i lekarzy. W kilku ostatnich latach, wraz ze znacznym rozwojem wiedzy i doświadczenia, sytuacja tej szczególnej grupy pacjentek diametralnie się zmieniła: dzisiaj kobiety mogą zachować ciążę, a jednocześnie skutecznie i bezpiecznie się leczyć – w sposób bardzo zbliżony do leczenia stosowanego u pacjentek niebędących w ciąży. Diagnostyka raka piersi u ciężarnej pokrywa się w znacznej mierze z ogólnie obowiązującymi standardami wykrywania i oceny zaawansowania tej choroby, poza kilkoma odstępstwami, związanymi przede wszystkim z bezpieczeństwem płodu. Różnice dotyczą m.in. procedury oceny węzła wartowniczego i części badań obrazowych. Kwalifikacja do leczenia i decyzje terapeutyczne zależą od zaawansowania ciąży i zaawansowania choroby, a niektóre procedury lecznicze muszą zostać bezwzględnie odroczone na czas po porodzie. Udowodniono bezpieczeństwo stosowania w czasie ciąży wybranych schematów chemioterapii jeszcze do niedawna uważanych za toksyczne i niemożliwe do wykorzystania u ciężarnej (FAC, FEC, taksoidy). Wykazano również, że – o ile nie istnieją położnicze wskazania do cesarskiego cięcia – w większości przypadków ciąża nie musi być rozwiązywana przed terminem, podobnie jak nie ma onkologicznych przeciwwskazań do porodu siłami natury. Niniejsza praca podsumowuje wiedzę płynącą z publikacji, które ukazały się w ostatnim czasie i pozwoliły na opracowanie standardów postępowania diagnostyczno-terapeutycznego w tych nieczęstych, ale jednocześnie bardzo skomplikowanych sytuacjach klinicznych.
Źródło:
Current Gynecologic Oncology; 2014, 12, 1; 14-24
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
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