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Wyszukujesz frazę "Oxidative stress" wg kryterium: Wszystkie pola


Tytuł:
Life with oxidative stress
Autorzy:
Gurda, D.
Kietrys, A.M.
Szopa, A.
Twardowski, T.
Powiązania:
https://bibliotekanauki.pl/articles/185377.pdf
Data publikacji:
2012
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
ROS
oxidative stress
antioxidants
oxidative stress response
stres oksydacyjny
przeciwutleniacze
reakcja na stres oksydacyjny
Opis:
Incomplete oxygen reduction gives rise to reactive oxygen species (ROS). For a long time they have been considered unwelcome companions of aerobic metabolism. Organisms using oxygen developed several systems of ROS scavenging with enzymatic and non enzymatic antioxidants, which allow them control the cellular level of oxygen derived from free radicals. It is well established nowadays that ROS are not necessarily negative byproducts, but they also play an important role in cellular mechanisms. They are involved in many regular cellular processes in all aerobic organisms. When the antioxidant system is overcome and the balance between ROS production and scavenging is disrupted, oxidative stress occurs. It has been reported that oxidative stress may be linked to some human diseases and is also involved in biotic and abiotic stress response in plants.
Źródło:
Chemical and Process Engineering; 2012, 33, 4; 509-528
0208-6425
2300-1925
Pojawia się w:
Chemical and Process Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dynamics of estrogen-induced oxidative stress
Autorzy:
Kobiela, Jarek
Stefaniak, Tomasz
Krajewski, Jacek
Kalinska-Blach, Beata
Zurawa-Janicka, Dorota
Lachinski, Andrzej
Gackowski, Daniel
Olinski, Ryszard
Nowak, Jerzy
Knap, narcyz
Lipinska, Barbara
Sledzinski, Zbigniew
Wozniak, Michal
Powiązania:
https://bibliotekanauki.pl/articles/1041076.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
8-oxodGuo
estradiol
protein oxidation
carcinogenesis
DNA damage
lipid peroxidation
Opis:
The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 289-295
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress in paraquat-treated lupine seedlings
Autorzy:
Olejniczak, D.
Rymer, K.
Rucinska-Sobkowiak, R.
Powiązania:
https://bibliotekanauki.pl/articles/80109.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
oxidative stress
paraquat
photosystem
lupin seed
photosynthetic electron transport
hydrogen peroxide
hydroxyl radical
reactive oxygen species
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of oxidative stress in ovarian cancer
Autorzy:
Rashmi, B.V.
Mukund, T.B.
Shubhangi, D.M.
Neelam, Y.
Vinayak, P.W.
Powiązania:
https://bibliotekanauki.pl/articles/1641.pdf
Data publikacji:
2018
Wydawca:
Uniwersytet Opolski. Instytut Nauk o Zdrowiu
Opis:
Background: Ovarian cancer is the fifth most common form of cancer in the world and is often asymptomatic in its early stages. Development of ovarian cancer-specific biomarkers for the early detection of disease could improve the current dismal survival rate. Evaluation of serum carbohydrate antigen 125 (CA125), alkaline phosphatase (ALP) and oxidative stress in ovarian carcinoma patients may improve the prognosis of the disease through earlier detection. Aim of the study: The aim of this study was to find the relative risk of ovarian cancer in patients screened for CA125, ALP, Nitric oxide (NO) and Malondialdehyde (MDA) as a marker for lipid peroxidation. Material and methods: 451 subjects with ovarian cancer were screened for serum CA125 levels using a chemiluminescence analyser, out of which 164 showed values above 21 U/ml. 80 subjects with higher values were further analysed for MDA and NO using spectrophotometry and AL P by fully automated chemistry analyser. Results: The selected 80 subjects with CA125 values above 74 U/ml had increased ALP, NO and MDA, also showing positive correlation amongst these parameters. Conclusions: Benefits of CA125 screening vary with age group according to blood CA125 levels. Enzyme ALP levels are elevated with higher values of CA125. MDA and NO indicate oxidative stress and increase as the ovarian marker values increase. Positive correlation amongst the parameters indicates a significant increase in oxidative stress in ovarian cancer. For women with various CA125 levels in different age groups, screening and treatment depends upon individual decision and clinical examination.
Źródło:
Medical Science Pulse; 2018, 12, 4
2544-1558
2544-1620
Pojawia się w:
Medical Science Pulse
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress – repair systems of oxidatively damaged biomolecules
Autorzy:
Kołodziej, U.
Maciejczyk, M.
Zalewska, A.
Powiązania:
https://bibliotekanauki.pl/articles/1918622.pdf
Data publikacji:
2018-06-18
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
oxidative stress
oxidative damage
oxidative stress repair systems
Opis:
Molecular oxygen (O2), constituting the basis of life on Earth, is classified as a substance with oxidizing properties. Reacting with organic compounds, it leads to their oxidation and at the same time participates in reduction processes. In aerobic organisms, over 90% of oxygen undergoes a total four-electron reduction to produce water molecules (O2 + 4 H+ + 4e- → 2 H2O). The remaining 10% of oxygen, however, is not fully reduced, which results in the production of molecules referred to as reactive oxygen species (ROS). In high concentrations ROS can interact with cellular components (DNA, proteins and lipids), leading to the oxidation of these macromolecules. The resulting oxidation products interfere with the proper functioning of the body by influencing gene expression, intercellular signaling and apoptosis. These changes have been observed in numerous pathological conditions, such as neurodegenerative, cardiovascular, metabolic, autoimmune diseases, and cancer. However, in the context of evolution, living organisms developed specialized repair mechanisms to prevent cellular accumulation of the products of DNA, protein and lipid oxidation, including enzymatic mechanisms (e.g. nucleases, proteases, phospholipases) or removal of damaged DNA, proteins and lipids by apoptosis or autophagy. This article briefly discusses the mechanisms of oxidative modification of cell components and the main repair systems responsible for the removal of lesions in cells by oxidative damage.
Źródło:
Progress in Health Sciences; 2018, 8(1); 141-150
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Response of Acanthamoeba castellanii mitochondria to oxidative stress
Autorzy:
Trocha, Lidia
Stobienia, Olgierd
Powiązania:
https://bibliotekanauki.pl/articles/1040871.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Acanthamoeba castellanii
hydroperoxide
mitochondria
oxidative stress
Opis:
The purpose of this study was to examine the effects of oxidative stress caused by hydroperoxide (H2O2) in the presence of iron ions (Fe2+) on mitochondria of the amoeba Acanthamoeba castellanii. We used isolated mitochondria of A. castellanii and exposed them to four levels of H2O2 concentration: 0.5, 5, 15, and 25 mM. We measured basic energetics of mitochondria: oxygen consumption in phosphorylation state (state 3) and resting state (state 4), respiratory coefficient rates (RC), ADP/O ratios, membrane potential (ΔΨm), ability to accumulate Ca2+ , and cytochrome c release. Our results show that the increasing concentrations of H2O2 stimulates respiration in states 3 and 4. The highest concentration of H2O2 caused a 3-fold increase in respiration in state 3 compared to the control. Respiratory coefficients and ADP/O ratios decreased with increasing stress conditions. Membrane potential significantly collapsed with increasing hydroperoxide concentration. The ability to accumulate Ca2+ also decreased with the increasing stress treatment. The lowest stress treatment (0.5 mM H2O2) significantly decreased oxygen consumption in state 3 and 4, RC, and membrane potential. The ADP/O ratio decreased significantly under 5 mM H2O2 treatment, while Ca2+ accumulation rate decreased significantly at 15 mM H2O2. We also observed cytochrome c release under increasing stress conditions. However, this release was not linear. These results indicate that as low as 0.5 mM H2O2 with Fe2+ damage the basic energetics of mitochondria of the unicellular eukaryotic organism Acanthamoeba castellanii.
Źródło:
Acta Biochimica Polonica; 2007, 54, 4; 797-803
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress induced autophagic cell death in plants
Autorzy:
Minibayeva, F.
Ryabovol, V.
Ponomareva, A.
Dmitrieva, S.
Sulkarnayeva, A.
Powiązania:
https://bibliotekanauki.pl/articles/79946.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
oxidative stress
cell death
autophagy
transmission electron microscopy
plant cell
disruption
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress in proliferative lesions of parathyroid gland
Autorzy:
Deska, Mariusz
Romuk, Ewa
Segiet, Oliwia
Polczyk, Joanna
Buła, Grzegorz
Gawrychowski, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/1392364.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
oxidative stress
primary hyperparathyroidism
parathyroid hyperplasia
parathyroid adenoma
Opis:
Background: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders and defined as excessive secretion of parathormone. PHPT is a risk factor of several cardiovascular diseases, which could be caused by alterations in oxidant-antioxidant balance. Materials and methods: Blood serum collected from 52 consecutive patients with PHPT treated surgically constituted our study material, whereas 36 healthy volunteers were our control group. Oxidative stress was evaluated in both patients and control subjects by assessment of malondialdehyde (MDA) and lipid hydroperoxides (LHP). Antioxidants were evaluated by the measurement of superoxide dismutase (SOD), ceruloplasmin (CER), catalase (CAT), sulfhydryl (SH) groups, glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione transferase activity (GST) and glutathione reductase (GR). Moreover, total antioxidant capacity (TAC) and total oxidative status (TOS) were measured and oxidative stress index (OSI) was calculated. Results: OSI was increased in patients with PHPT when compared to normal controls, whereas TAC was lower in PHPT. The levels of CER, MnSOD, GR, SH groups and MDA were significantly decreased in PHPT. The levels of serum LHP, catalase and SOD were significantly higher in patients with PHPT than in healthy patients. The erythrocyte CAT activity and GST were significantly increased in patients after parathyroidectomy. The erythrocyte GR and GPx were up-regulated postoperatively, whereas SOD activity decreased. Conclusions: In PHPT there are several alterations in the balance between the production of reactive oxygen species and antioxidant defense system.
Źródło:
Polish Journal of Surgery; 2019, 91, 1; 29-34
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Alkohol a stres oksydacyjny
Alcohol and oxidative stress
Autorzy:
Świderska-Kołacz, Grażyna
Kumański, Krzysztof
Parka, Barbara
Powiązania:
https://bibliotekanauki.pl/articles/1194758.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Opis:
Etanol ma istotny wpływ na proces wytwarzania reaktywnych form tlenu, a tym samym na generowanie stresu oksydacyjnego. Dokonano charakterystyki RFT oraz opisano mechanizm ich powstawania. Oksydacyjnym uszkodzeniom ulegają białka, DNA i lipidy. Istotna rolę odgrywają reaktywne formy tlenu w procesach chorobotwórczych u osób przewlekle spożywających alkohol. Wśród chorób związanych z oddziaływaniem RFT i nadużywaniem alkoholu wyróżnia się: choroby wątroby, miażdżycę, nadciśnienie tętnicze, rozwój nowotworów, spadek odporności, zaburzenia funkcji seksualnych, a także przyspieszenie procesu starzenia się skóry. Organizm ochraniają antyoksydanty wewnątrzkomórkowe i zewnątrzkomórkowe.
Ethanol significantly influences formation of reactive oxygen species (ROS) in cells, and thus generation therein of oxidative stress. At present, ROS and mechanisms of their formation and action are well characterized. Under the stress condition, proteins, DNA and lipids undergo oxidative damages. In persons consuming alcohol protractedly, ROS play an important role in etiology of pathogenic processes, in particular such as liver diseases, arteriosclerosis, arterial hypertension, development of tumors, decrease in immunity, disorder of sexual functions, and acceleration of skin aging. Intracellular and outside antioxidants help to protect organism from the oxidative stress.
Źródło:
Kosmos; 2012, 61, 1; 93-103
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Alergia a stres oksydacyjny
Allergy and Oxidative Stress
Autorzy:
Twardoch, Magdalena A.
Lodwich, Magdalena
Mazur, Bogdan
Powiązania:
https://bibliotekanauki.pl/articles/1036585.pdf
Data publikacji:
2016
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
stres oksydacyjny
reaktywne formy tlenu
astma oskrzelowa
alergiczny nieżyt nosa
atopowe zapalenie skóry
atopic dermatitis
oxidative stress
reactive oxygen species
bronchial asthma
allergic rhinitis
Opis:
Oxygen is a biogenic element which determines the course of basic biochemical processes to ensure the survival of the cell. Unfortunately, in particular circumstances, the highly reactive oxygen species (ROS) may cause a toxic effect on the body. Small amounts of ROS are essential for the proper functioning of cells, however, the excessive production of them, which transcend the effectiveness of antioxidant systems – defined as oxidative stress – promotes structural and functional disorders of cells and tissues. Nowadays, the significant participation of oxidative stress is increasingly more frequently indicated in the course and/or etiology of chronic inflammatory diseases, which include atopic diseases such as bronchial asthma, atopic dermatitis, or allergic rhinitis.
Tlen jako pierwiastek biogenny warunkuje przebieg podstawowych procesów biochemicznych gwarantujących przeżycie komórki. Niestety, w szczególnych warunkach wysoce reaktywne formy tlenu (RFT) mogą wywierać toksyczny efekt na organizm. W niewielkich ilościach RFT są niezbędne do prawidłowego funkcjonowania komórki, jednak ich nasilone wytwarzanie, przekraczające skuteczność działania systemów antyoksydacyjnych, określane mianem stresu oksydacyjnego, sprzyja zaburzeniom struktury i funkcji komórek oraz tkanek. Współcześnie coraz częściej wskazuje się na istotny udział stresu oksydacyjnego w przebiegu i/lub etiologii przewlekłych chorób zapalnych, do których zalicza się m.in. choroby atopowe, takie jak astma oskrzelowa, atopowe zapalenie skóry czy alergiczny nieżyt nosa.
Źródło:
Annales Academiae Medicae Silesiensis; 2016, 70; 15-23
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Inference of oxidative stress in patients with hypothyroidism
Autorzy:
Rada, Feryal
Powiązania:
https://bibliotekanauki.pl/articles/40555549.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
glutathione
hypothyroidism
malondialdehyde
oxidative stress
paraoxonase-1
Opis:
Introduction and aim. Oxidative stress is one of the complications that accompany defects in thyroid hormone levels. This study was designed to evaluate oxidative stress markers in patients with hypothyroidism. Material and methods. This case control study was comprised of forty-two hypothyroid patients aged 36–46 years and forty age matched (35–43 years) healthy control participants randomly selected from the Endocrine Clinic of Al-Yarmook Hospital in Iraq. Blood levels of thyroid hormones malondialdehyde, glutathione, and paraoxonase-1 were assessed. Body mass index was calculated for each patient and control participant. Results. Regarding the data of oxidative stress markers in hypothyroid patients compared to controls, a significant elevation was reported in blood levels of malondialdehyde and a significant reduction was found in blood levels of glutathione (p=0.031). On the other hand, the blood levels of paraoxonase-1 were significantly different in hypothyroid patients compared with the control. Conclusion. Elevated blood levels of malondialdehyde and declined blood levels of glutathione in hypothyroid patients are a signal of oxidative stress and consequently increase the risk of cardiovascular complications.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 270-274
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Isoprostanes – A novel major group of oxidative stress markers
Autorzy:
Czerska, Marta
Zieliński, Marek
Gromadzińska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/2177073.pdf
Data publikacji:
2015-10-16
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
isoprostanes
cardiovascular
pulmonary
neurological
oxidative stress biomarkers
asbestosis
Opis:
Isoprostanes are a recently discovered group of prostaglandin isomers. Results of previous studies suggest that they can be used as oxidative stress markers, because in a number of cardiovascular, pulmonary and neurological diseases their levels in biological samples considerably increase. It has been found that people suffering from diabetes, obesity, homozygous familial hypercholesterolemia, moderate hypercholesterolemia, and smokers have higher levels of isoprostanes in urine. The same refers to patients with asthma, Alzheimer disease and Down syndrome. This paper reviews the results of relevant studies.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2016, 29, 2; 179-190
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Functional characterisation of tissue specific acclimation to oxidative stress
Autorzy:
Spruyt, L.
Hoeberichts, F.
Muhlenbock, P.
Van Breusegem, F.
Powiązania:
https://bibliotekanauki.pl/articles/81021.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
functional characteristics
oxidative stress
biotic stress
abiotic stress
stress condition
reactive oxygen species
photorespiration
hydrogen peroxide
catalase
Arabidopsis thaliana
tissue
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Today’s oxidative stress markers
Współczesne markery stresu oksydacyjnego
Autorzy:
Czerska, Marta
Mikołajewska, Karolina
Zieliński, Marek
Gromadzińska, Jolanta
Wąsowicz, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/2165384.pdf
Data publikacji:
2015-07-09
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
izoprostany
stres oksydacyjny
markery stresu oksydacyjnego
alantoina
metabolity izoprostanów
isoprostanes
Oxidative stress
oxidative stress markers
allantoin
metabolites of isoprostanes
Opis:
Oxidative stress represents a situation where there is an imbalance between the reactive oxygen species (ROS) and the availability and the activity of antioxidants. This balance is disturbed by increased generation of free radicals or decreased antioxidant activity. It is very important to develop methods and find appropriate biomarkers that may be used to assess oxidative stress in vivo. It is significant because appropriate measurement of such stress is necessary in identifying its role in lifestyle-related diseases. Previously used markers of oxidative stress, such as thiobarbituric acid reactive substances (TBARS) or malondialdehyde (MDA), are progressively being supplemented by new ones, such as isoprostanes (IsoPs) and their metabolites or allantoin. This paper is focusing on the presentation of new ones, promising markers of oxidative stress (IsoPs, their metabolites and allantoin), taking into account the advantage of those markers over markers used previously. Med Pr 2015;66(3):393–405
Stres oksydacyjny jest stanem braku równowagi między działaniem reaktywnych form tlenu (RFT) a działaniem antyoksydantów. Równowaga ta może być zakłócona w wyniku zwiększonego działania wolnych rodników lub spadku aktywności antyoksydacyjnej. Zaburzenia te mogą występować zarówno na poziomie komórkowym, jak i całego organizmu. Ponieważ stres oksydacyjny może być podłożem wielu zespołów chorobowych, niezwykle istotne jest znalezienie odpowiednich markerów, które mogą być wykorzystane do oceny jego poziomu in vivo. Stosowane od wielu lat markery – ocenę stężenia aldehyd dimalonowy (MDA) i substancji reagujących z kwasem tiobarbiturowym (thiobarbituric acid reactive substances – TBARS) – stopniowo uzupełnia się nowymi, takimi jak alantoina czy izoprostany (IzoP) wraz z ich metabolitami (IzoP-M). W niniejszej pracy skupiono się na zaprezentowaniu nowych, obiecujących markerów stresu oksydacyjnego (alantoina, IzoP, IzoP-M), ukazując korzyści wynikające z ich stosowania i prognozując dalsze kierunki badań nad ich zastosowaniem. Med. Pr. 2015;66(3):393–405
Źródło:
Medycyna Pracy; 2015, 66, 3; 393-405
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nutritional profile and oxidative stress in adolescent soccer players
Autorzy:
Milani Guissoni, Francine
Deminice, Rafael
Payão Ovidio, Paula
Zangiacomi Martinez, Edson
Jordao, Alceu Afonso
Mialich, Mirele S.
Powiązania:
https://bibliotekanauki.pl/articles/1030959.pdf
Data publikacji:
2020
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
alceu@fmrp.usp.br
Opis:
High-intensity exercise increases reactive oxygen species formation, which in excess may cause oxidative stress. We assessed nutritional status and exercise-induced oxidative stress in 20 adolescent male soccer players (age: 15-17). Participants were divided into two teams for a 60-minute friendly match and evaluated immediately before (Pre-match), 30 minutes after (Post-match I) and 24 hours after (Post-match II) the game. All players recorded a 3-day dietary intake. Biochemical tests were performed for lipid profile, muscle damage (creatinine and creatinine kinase [CK]) and oxidative stress (thiobarbituric acid-reactive substances [TBARS], protein carbonyls [PC], reduced glutathione [GSH], and vitamins E, C, and A). CK and creatinine were significantly elevated at Post-match I (p < 0.01), returning to baseline at Post-match II. Vitamins E, C and A were significantly elevated at Post-match I (p < 0.01), but only vitamins E and A remained high at Post-match II. TBARS showed no significant changes. GSH showed a significant decrease (p < 0.01) and PC showed a slight but significant increase (p < 0.01) at Post-match II. The recruitment of non-enzymatic antioxidants prevented lipid peroxidation, but dietary and especially endogenous defence responses were insufficient to prevent protein oxidation. Proper nutrition is essential to improve the activity of the antioxidant defence system, preventing exercise-induced oxidative stress.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2020, 32, 4; 51-59
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of oxidative stress in crops treated with glyphosate herbicide
Autorzy:
Utarbayeva, A.
Sapko, O.
Chebonenko, O.
Amirkulova, A.
Powiązania:
https://bibliotekanauki.pl/articles/80618.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
oxidative stress
crop
glyphosate
herbicide
lipid peroxidation
hydrogen peroxide
reactive oxygen species
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stres oksydacyjny w raku piersi
Oxidative stress in breast cancer
Autorzy:
Kędzierska, Magdalena
Olas, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1194693.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Przyrodników im. Kopernika
Opis:
Stres oksydacyjny definiowany jest jako zachwianie równowagi pomiędzy powstawaniem (nadprodukcją) wolnych rodników, a zdolnościami indywidualnych mechanizmów obronnych. Produkcja wolnych rodników jest stałym elementem metabolizmu tlenowego komórki. Jest powszechnie wiadomo, że stres oksydacyjny wywołuje wiele stanów patologicznych i chorób. Stres oksydacyjny jest przyczyną uszkodzeń wielu ważnych makromolekuł, do których zaliczamy: DNA, białka i lipidy. Wzrost poziomu wolnych rodników wpływa też na transformację nowotworową komórki. Procesowi formowania i rozwojowi nowotworu towarzyszy zachwianie równowagi redox w komórce, nadprodukcja reaktywnych form tlenu i azotu. Obecnie rak piersi jest najczęstszym nowotworem złośliwym u kobiet w Polsce i na świecie. Biologia tego nowotworu i jego kliniczny obraz jest bardzo heterogenny. Stres oksydacyjny i zmiany oksydacyjno-nitracyjne są często obserwowane u chorych z rakiem piersi, ale nadal mechanizmy relacji między stresem oksydacyjnym czy nitracyjnym a rakiem piersi są niejasne. Stres oksydacyjny i nitracyjny obserwowany u pacjentów chorych na raka piersi może również indukować zmiany strukturalne i zmiany funkcji różnych elementów układu hemostazy. Organizm człowieka wyposażony jest w kilka sposobów ochrony przed atakiem oksydacyjnym. Mechanizmy obrony obejmują różne enzymy antyoksydacyjne, do których zaliczamy: peroksydazę glutationową, katalazę, dysmutazę ponadtlenkową i inne substancje, takie jak niskocząsteczkowe tiole: glutation, cysteinę, witaminę E, C i A, które eliminują wolne rodniki. Jest to bardzo istotne szczególnie dla chorych z rakiem piersi podczas chemioterapii wielolekowej, czy przed- lub pooperacyjnej radioterapii.
Oxidative stress may be defined as an imbalance between reactive oxygen species and the individual antioxidant defense system. Reactive oxygen species formation is a constant element of a cell's oxygen metabolism. It is now known that oxidative stress is involved in most of pathological states and diseases. Oxidative stress causes damage to important macromolecules, such as DNA, proteins, and lipids. Growing evidence indicates the participation of free radicals in the cancerous transformation of cells. The process of cancer formation and development is associated with loss of redox balance in the cell and with overproduction of reactive oxygen and nitrogen species. Actually breast cancer is the most common malignant neoplasm in women both in Poland and worldwide. It is biologically and clinically very heterogenous disease. Oxidative stress and oxidative-nitrative changes in the cells are frequently observed in breast cancer patients, but until now mechanisms involved in the relationship between oxidative stress and breast cancer are still unclear. Oxidative stress species may also induce changes to the structure and function in hemostatic elements. Human organisms have developed several ways to protect themselves from oxidant attacks. The defense mechanisms include a variety of antioxidant enzymes like glutathione peroxidase, catalase and superoxide dismutase and other substances such as low-molecular-weight thiols, such as glutathione, cysteine and vitamins E, C and A, which provide to eliminate free radicals are very important for the development of breast cancer and during multichemotherapy with different anti-cancer drugs or pre- and postoperative radiation therapy.
Źródło:
Kosmos; 2012, 61, 4; 547-555
0023-4249
Pojawia się w:
Kosmos
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ethylene mediates in the early oxidative stress induced by mercury
Autorzy:
Montero-Palmero, M.
Martin-Barranco, A.
Alonso, J.
Escobar, C.
Hernandez, L.
Powiązania:
https://bibliotekanauki.pl/articles/81164.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
oxidative stress
plant
mercury
homeostasis
reactive oxygen species
alfalfa
Medicago sativa
1-methylcyclopropene
NADPH oxidase
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mercury induced oxidative stress of antioxidants in Clitoria ternatea L.
Autorzy:
Priya, M.
Balakrishnan, V.
Kiruthika Lakshmi, A.
Aruna, R.
Ravindran, K.C.
Powiązania:
https://bibliotekanauki.pl/articles/10952.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
biofertilizer
enzyme
mercury
metal stress
oxidative stress
antioxidant
Clitoria ternatea
Opis:
Biofertilizers are the special formulation of specific beneficial microorganisms that promote the growth of plant crops by converting the unavailable form of nutrients into available form. Here, the effect of heavy metal stress on antioxidant enzymes were studied in Clitoria ternatea L. leaves. Clitoria ternatea L. plant was grown for 30 days and the heavy metal mercuric chloride was sprayed after 10 days from the date of planting. Effect of mercuric chloride was observed in treated plants. The selected plant Clitoria ternatea L. was grown under mercuric chloride treatment in a specified concentration 1 μg/10 ml. The control plant maintained without the treatment of mercuric chloride. Antioxidant effect of mercuric chloride was measured under controlled and treated conditions. The selected plant Clitoria ternatea L. was grown under mercuric chloride in treatment. Further it increases H2O2 content and the antioxidant enzyme activities such as superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD) were observed in mercuric chloride treated plants when compared with control. Here mercuric chloride was accumulated more in matured leaves. The results are discussed with the literature.
Źródło:
International Letters of Natural Sciences; 2014, 18
2300-9675
Pojawia się w:
International Letters of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Selectivity of oxidative stress targeting in estrogen-induced experimental nephrocarcinogenesis.
Autorzy:
Kobiela, Jarek
Krajewski, Jacek
Kalińska-Błach, Beata
Stefaniak, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/1043806.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
estrogen-induced carcinogenesis
protein carbonyl group
renal carcinogenesis
oxidative stress
Opis:
Specificity of targeting of the oxidative stress towards lipid and protein fractions in a model of estrogen-induced Syrian hamster nephrocarcinogenesis was evaluated. The amount of proteins modified by oxidative stress was significantly elevated as early as one month after the initial implantation of estradiol to the experimental versus the control group, while the stress did not affect lipids. Subcellular localization of the oxidative stress target was determined by the analysis of protein oxidation in subcellular fractions of kidney cells. The endoplasmic reticulum membranes were the fraction most affected by the oxidative stress.
Źródło:
Acta Biochimica Polonica; 2002, 49, 1; 51-58
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of selenium on oxidative stress in athletes. Review article
Autorzy:
Sieja, Krzysztof
von Mach-Szczypińska, Joanna
Kois, Natalia
Ler, Paulina
Piechanowska, Klaudia
Stolarska, Michalina
Powiązania:
https://bibliotekanauki.pl/articles/1055002.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
athletes
gluthatione peroxidase
malondialdehyde
physical exercise
selenium
Opis:
The aim of the study was to analyze the influence of selenium (Se) on the course of oxidative stress in trained athletes, on the basis of own former published studies and the reference of literature. In a number of references it was shown that the application of Se led to the diminishing of oxidative stress during the physical exercises in athletes. The application of Se to athletes − led to the increase of peroxidase glutathione the main selen − dependent enzyme. The fact of increased concentration of malondialdehyde (MDA) in blood serum, the main metabolite of lipid peroxidation can indirectly evidence about the intensity of physical endurance. This increase is significantly smaller in individuals taking exogenous antioxidative diet supplement containing Se. Moreover there is the evidence that oxidative muscles damage during physical effort could be diminished by compounds with antioxidative properties. Taking into consideration, the obtained results by many of authors empower to the conclusion that application of Se diminishes the degree of peroxidation of lipids in trained athletes.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2016, 14, 2; 87 - 92
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stres oksydacyjny Część I. Stres oksydacyjny jako czynnik rozwoju chorób cywilizacyjnych
Oxidative stress Part I. Oxidative stress as a factor in the development of civilization diseases
Autorzy:
Jopkiewicz, Sylwia
Powiązania:
https://bibliotekanauki.pl/articles/1035230.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
"choroby cywilizacyjne"
"reaktywne formy tlenu"
"wolne rodniki tlenowe"
Opis:
Homeostasis of an organism and its proper functioning are determined by the oxidative-antioxidant balance. Its disorder is most often associated with overproduction of reactive oxygen species that cause oxidative stress. This, in turn, lies at the heart of the development and course of many diseases, especially those that are classified as civilization diseases. Environmental pollution, chronic stress, low levels of physical activity, and improper nutrition are among the determinants of the production of an increased amount of free radicals. Their destructive action consists in the oxidation of cell components, which in turn leads to damage and disturbance of the physiological functions of the cell. Free radicals change the structure and modify the functions of proteins. In addition, they destroy DNA structures. The present review article outlines the problem of the participation of oxidative stress in the pathogenesis of selected civilization diseases. The concept and role of free radicals and reactive oxygen species in the human body are presented. Next, their participation in the development and course of individual diseases is discussed.
Homeostaza organizmu i jej odpowiednie funkcjonowanie determinowana jest przez równowagę oksydacyjno-antyoksydacyjną. Jej zaburzenie związane jest najczęściej z nadprodukcją reaktywnych form tlenu, które powodują stres oksydacyjny. Ten natomiast leży u podstaw rozwoju i przebiegu wielu chorób, a zwłaszcza tych, które zaliczane są do schorzeń cywilizacyjnych. Zanieczyszczenie środowiska, przewlekły stres, niski poziom aktywności fizycznej oraz nieprawidłowe odżywianie są jednymi z determinantów wytwarzania zwiększonej ilości wolnych rodników. Ich destrukcyjne działanie polega na utlenianiu składników komórki, co w konsekwencji prowadzi do uszkodzeń i zaburzeń jej funkcji fizjologicznych. Wolne rodniki zmieniają strukturę oraz modyfikują funkcje białek. Ponadto niszczą struktury DNA. Prezentowany artykuł poglądowy stanowi zarys problematyki udziału stresu oksydacyjnego w patogenezie wybranych chorób cywilizacyjnych. Scharakteryzowano pojęcie oraz rolę wolnych rodników i reaktywnych form tlenu w organizmie człowieka. Następnie omówiono ich udział w rozwoju i przebiegu poszczególnych schorzeń.
Źródło:
Medycyna Środowiskowa - Environmental Medicine; 2018, 21, 2; 48-52
1505-7054
2084-6312
Pojawia się w:
Medycyna Środowiskowa - Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Obesity, lipid profiles and oxidative stress in children after liver transplantation
Autorzy:
Czubkowski, Piotr
Wierzbicka, Aldona
Pawłowska, Joanna
Jankowska, Irena
Socha, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1038555.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
reactive oxygen species
apolipoprotein
atherosclerosis
cholesterol
Opis:
Purpose. In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after pediatric liver transplantation (LTx). Method. We performed prospective analysis of 74 children, at the median age of 7.9 (2.8-11.6) years, 3.2 (1.2-4.3) years after LTx. We assessed the BMI Z-scores, cholesterol fractions (LDLc, HDLc, VLDLc), triglicerides, apolipoproteins (ApoAI, ApoB, ApoE), LCAT, insulin resistance by HOMA-IR and markers of oxidative stress and atherosclerosis: glutathione (GSH), glutathione peroxidase (GPx), asymmetrical dimethyl arginine (ADMA) and oxidized low-density lipoprotein (oxyLDL). At baseline, the results were compared with a healthy age-and-sex matched control group. After 3.1±0.3 year follow-up we repeated all investigations and compared them with the baseline results. RESULTS. At the baseline, we investigated 74 patients 3.2 (1.2-4.3) years after LTx, at the median age of 7.9 (2.8-11.6) years. The prevalence of overweight or obesity (BMI >85th percentile) was 23% and was more common in girls (24% vs 20%). Fourteen patients had TCH >200 mg%, 9 patients had LDLc >130 mg% and TG were at normal levels in all patients. Compared to the controls, there were no significant differences in lipid profiles but we found decreased GSH (p<0.001) and GPx (p<0.001) which play role as an antioxidant defense. OS markers were higher in the study group: ADMA (p<0.001), and oxyLDL (p<0.0001). Insulin resistance by HOMA-IR was increased in the study group (p=0.0002) but fasting glucose remained within normal ranges in all patients. After 3.1-year follow-up, the BMI >95th and >85Th percentile was present in 8% and 14% respectively. ADMA and oxyLDL decreased, whilst GSH and GPx increased when compared to the baseline. There was also significant decrease in apoB and Lp(a). Conclusion. Children after LTx had normal lipid profiles when compared to controls, however there is a tendency for hypercholesterolemia and obesity, which may play a role in cardiovascular complications in the future. Some markers of oxidative stress were increased after LTx, however further investigations are required to establish its clinical significance.
Źródło:
Acta Biochimica Polonica; 2017, 64, 4; 661-665
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction
Autorzy:
Omon, Emmanuel Akokhamen
Ajay, Olawale David
Powiązania:
https://bibliotekanauki.pl/articles/29520465.pdf
Data publikacji:
2023-12-31
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
antioxidants
dysfunction
malondialdehyde
oxidative stress
thyroid hormone
Opis:
Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 4; 768-775
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Female headstart in resistance to hyperoxia-induced oxidative stress in mice
Autorzy:
Šarić, Ana
Sobočanec, Sandra
Šafranko, Željka
Popović-Hadžija, Marijana
Aralica, Gorana
Korolija, Marina
Kušić, Borka
Balog, Tihomir
Powiązania:
https://bibliotekanauki.pl/articles/1039219.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hyperoxia
sex-related
mice
ROS
Sirt1
PPAR-γ
eNOS
Sod2
Opis:
Increased oxygen concentration (hyperoxia) induces oxidative damage of tissues and organs. Oxygen toxicity in hyperoxia is controlled by factors such as sex, age, tissue, strain and hormones. In most species females show lower incidence of some age-related pathologies linked with oxidative stress, which has been attributed to a beneficial effect of ovarian hormones. In this study we found that hyperoxia induced hepatic oxidative damage exclusively in male CBA/H mice, followed by their decreased survival. Histopathological examination revealed that the observed differences in survival were not the consequence of acute lung injury induced by hyperoxia. Next, we observed that an increased Sirt1 protein level in hyperoxia-exposed female CBA/H mice correlated with their lower PPAR-γ and higher eNOS and Sod2 protein levels. In males, higher PPAR-γ and lower Sod2 protein levels were associated with unchanged Sirt1 expression. Although these results are of a correlative nature only, they clearly show that females show better survival, increased resistance to hyperoxia and have generally more efficient defense systems, which suggests that their headstart in resistance to hyperoxia could be a consequence of the beneficial effect of ovarian hormones.
Źródło:
Acta Biochimica Polonica; 2014, 61, 4; 801-807
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress-induced growth inhibitor 1 in alcohol-induced liver cirrhosis
Autorzy:
Sak, J.J.
Prystupa, A.
Bis-Wencel, H.
Kiciński, P.
Luchowska-Kocot, D.
Krukowski, H.
Nowicki, G.J.
Panasiuk, L.
Powiązania:
https://bibliotekanauki.pl/articles/28761891.pdf
Data publikacji:
2021
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2021, 28, 4; 676-680
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of ascorbate during cadmium-induced oxidative stress in Arabidopsis thaliana
Autorzy:
Bielen, A.
Remans, T.
Vangronsveld, J.
Cuypers, A.
Powiązania:
https://bibliotekanauki.pl/articles/79901.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
cadmium
oxidative stress
reactive oxygen species
cellular level
antioxidant defense system
stress condition
ascorbate peroxidase
Arabidopsis thaliana
ascorbate-glutathione cycle
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress, apaptosis and stess proteins
Stres oksydacyjny, apoptoza a białka stresowe
Autorzy:
Jethon, Z.
Powiązania:
https://bibliotekanauki.pl/articles/366509.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
Tematy:
stres oksydacyjny
białka stresowe
apoptoza
adaptacja
nurkowanie
oxidative stress
stress proteins
apoptosis
adaptation
diving
Opis:
Reactive oxygen species are constantly generated in aerobic processes in the organism. At the beginning their appearance in tissues were considered to be dangerous, leading to numerous diseases, mutagenesis, degenerative processes and aging. With time their physiological role was discovered as factors regulating numerous internal processes. Oxidative stress can appear as a consequence of influence of various external and internal factors acting especially as stressors. The factors of diving environment are usually stressors. Physical work performance leads also to enhancement of reactive oxygen generation. As a response there is synthesized several stress proteins, which are involved in homeostasis maintenance, cell survival promotion and in cytoprotection. If this protective role is insufficient there appear a cell destruction and cell death due to apoptosis or necrosis. These two processes are close related. The appearance of oxidative stress and apoptosis does not always result in cell death. Less intensive they act in remodeling of the cell that has an adaptative character. This process is under supervision of stress proteins.
Reaktywne formy tlenu są stale wytwarzane w organizmie w procesach przemian o charakterze tlenowym. Początkowo ich obecność w tkankach była traktowana jako niekorzystne zjawisko, łączone z różnymi schorzeniami, mutagenezą, procesami degeneracyjnymi i biologicznym starzeniem się organizmu. Z czasem poznano jednak ich fizjologiczne znaczenie w zakresie regulacji różnych procesów wewnątrzustrojowych. Stres oksydacyjny może powstać w wyniku wpływu różnych czynników zewnątrz- i wewnątrzpochodnych, zwłaszcza mających charakter stresora. Czynniki występujące w nurkowaniu ten charakter zazwyczaj mają. Obok nich, wykonywanie pracy fizycznej prowadzi także do zwiększenia ilości powstających reaktywnych form tlenu. W odpowiedzi na stres organizm wytwarza szereg białek stresowych, które regulują homeostazę wewnątrzkomórkową, ułatwiają przeżywanie komórki i odgrywają zasadniczą rolę w ochronie komórki. W razie niedostatecznej ochrony powstaję uszkodzenie komórki i jej śmierć poprzez apoptozę lub nekrozę. Oba procesy są ściśle ze sobą związane. Zmiany wywołane stresem oksydacyjnym i pojawienie się apoptozy nie zawsze prowadzą do śmierci komórki. W mniej intensywnym wymiarze służą przebudowie komórki, mającej znaczenie adaptacyjne. Proces ten jest pod nadzorem białek stresowych.
Źródło:
Polish Hyperbaric Research; 2005, 1(10); 6-13
1734-7009
2084-0535
Pojawia się w:
Polish Hyperbaric Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Związek stresu oksydacyjnego z jaskrą
The role of oxidative stress in glaucoma
Autorzy:
Rokicki, Wojciech
Kabiesz, Adam
Romaniuk, Wanda
Powiązania:
https://bibliotekanauki.pl/articles/1037949.pdf
Data publikacji:
2014
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
jaskra
stres oksydacyjny
glaucoma
oxidative stress
Opis:
Glaucoma has long been considered exclusively a disease of the eye. Today it is known that glaucoma is an occular manifestation of systemic diseases. The pathomechanisms of glaucoma seem to be similar to those observed in other neurodegenerative disorders such as Alzheimer’s disease where nerve cell death, oxidative damage and inflammatory response are observed. The one known and proved glaucoma risk factor – elevated intraocular pressure (IOP), is neither necessary nor sufficient for the development and progression of glaucoma. What is more, IOP normalization does not always prevent disease progression. The data on oxidative stress in glaucomatous disturbances seem not only to conflict other observations but rather complement the mechanical, vascular, genetic and immunologic theories of glaucoma pathogenesis. The aim of the work is a summary of the latest research on the role of oxidative stress in glaucoma.
Do niedawna jaskra była uważana za schorzenie wyłącznie okulistyczne. Dzisiaj wiadomo, że jest ona oczną manifestacją ogólnoustrojowych zaburzeń. Patomechanizmy występujące w jaskrze wydają się podobne do obserwowanych w pozostałych chorobach neurodegeneracyjnych, takich jak np. choroba Alzheimera, gdzie obserwuje się śmierć komórek nerwowych, uszkodzenia związane z szokiem tlenowym, azotowym i odpowiedzią zapalną. Jedyny znany i potwierdzony czynnik ryzyka jaskry – podwyższone ciśnienie wewnątrzgałkowe (CWG) nie jest ani wystarczający, ani konieczny do rozwoju i progresji jaskry. Normalizacja CWG często nie zapobiega postępowi choroby. Obserwacje związku stresu oksydacyjnego z jaskra zdają się nie tylko nie zaprzeczać innym teoriom rozwoju jaskry (mechanicznym, naczyniopochodnym, genetycznym i immunologicznym), ale je uzupełniać. Celem pracy jest zestawienie najnowszych wyników badań nad rolą stresu oksydacyjnego w patogenezie jaskry.
Źródło:
Annales Academiae Medicae Silesiensis; 2014, 68, 1; 62-65
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Changes in oxidative stress markers in plasma of sows during periparturient period
Autorzy:
Szczubiał, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087316.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
oxidative stress markers
lipid and protein peroxidation
periparturient period
plasma
sows
Źródło:
Polish Journal of Veterinary Sciences; 2020, 23, 2; 185-190
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Stres oksydacyjny a środowisko wysokogórskie
Oxidative stress and the high altitude environment
Autorzy:
Krzeszowiak, Jakub
Powiązania:
https://bibliotekanauki.pl/articles/1178702.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Tematy:
niedotlenienie
stres oksydacyjny
środowisko wysokogórskie
Opis:
In the recent years there has been considerable interest in mountain sports, including mountaineering, owing to the general availability of climbing clothing and equipment as well trainings and professional literature. This raised a new question for the environmental and mountain medicine: Is mountaineering harmful to health? Potential hazards include the conditions existing in the alpine environment, i.e. lower atmospheric pressure leading to the development of hypobaric hypoxia, extreme physical effort, increased UV radiation, lack of access to fresh food, and mental stress. A reasonable measure of harmfulness of these factors is to determine the increase in the level of oxidative stress. Alpine environment can stimulate the antioxidant enzyme system but under specific circumstances it may exceed its capabilities with simultaneous consumption of low-molecular antioxidants resulting in increased generation of reactive oxygen species (ROS). This situation is referred to as oxidative stress. Rapid and uncontrolled proliferation of reactive oxygen species leads to a number of adverse changes, resulting in the above-average damage to the lipid structures of cell membranes (peroxidation), proteins (denaturation), and nucleic acids. Such situation within the human body cannot take place without resultant systemic consequences. This explains the malaise of people returning from high altitude and a marked decrease in their physical fitness. In addition, a theory is put forward that the increase in the level of oxidative stress is one of the factors responsible for the onset of acute mountain sickness (AMS). However, such statement requires further investigation because the currently available literature is inconclusive. This article presents the causes and effects of development of oxidative stress in the high mountains.
Znaczne zainteresowanie w ostatnich latach sportami górskimi, w tym alpinizmem, przez popularyzacje tych sportów, ogólną dostępność szkoleń i fachowej literatury postawiła nowe pytania przed medycyną środowiskową i górską – czy alpinizm jest szkodliwy dla zdrowia. Z uwagi na warunki jakie panują w środowisku wysokogórskim tj. obniżone ciśnienie atmosferyczne prowadzące do rozwoju hipoksji hipobarycznej, ekstremalnie ciężki wysiłek fizyczny, wzmożone promieniowanie UV, brak dostępu do świeżej żywności oraz stres psychiczny. Zasadną miarą szkodliwości tych warunków jest określenie wzrostu poziomu stresu oksydacyjnego. Środowisko wysokogórskie może oddziaływać bodźcowo na enzymatyczny układ antyoksydacyjny lecz w szczególnych sytuacjach może przewyższać jego możliwości przy jednoczesnym zużyciu antyoksydantów niskocząsteczkowych czego konsekwencją jest wzmożona generacja reaktywnych form tlenu (RFT). Ta sytuacja jest określana mianem stresu oksydacyjnego. Gwałtowne i niekontrolowane namnażanie reaktywnych form tlenu prowadzi do wielu niekorzystnych przemian prowadzących do ponad przeciętnej ilości uszkodzeń lipidowych struktur błony komórkowej (peroksydacji), białek (denaturacja) oraz kwasów nukleinowych. Sytuacja taka w obrębie organizmu ludzkiego nie może wystąpić bez następczych konsekwencji ogólno ustrojowych. Tym właśnie jest tłumaczone złe samopoczucie po powrocie z wysokości oraz wyraźne obniżenie wydolności fizycznej. Dodatkowo jest wysuwana teoria jako by to wzrost poziomu stresu oksydacyjnego był jednym z czynników odpowiedzialnych za rozwój ostrej choroby wysokogórskiej (ang. acute moutain sickness – AMS). Stwierdzenie to jednak wymaga dalszych badań ponieważ aktualnie dostępne piśmiennictwo na ten temat nie jest jednoznaczne, a artykuł ten dotyczy przyczyn rozwoju stresu oksydacyjnego w górach wysokich oraz jego skutków.
Źródło:
Medycyna Środowiskowa - Environmental Medicine; 2013, 16, 1; 90-97
1505-7054
2084-6312
Pojawia się w:
Medycyna Środowiskowa - Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Novel roles for glutathione in linking oxidative stress to phytohormone-dependent signalling
Autorzy:
Noctor, G.
Han, Y.
Chaouch, S.
Mhamdi, A.
Powiązania:
https://bibliotekanauki.pl/articles/80088.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
glutathione
oxidative stress
phytohormone
antioxidant
protein structure
protein function
signalling
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
QUERCETIN ATTENUATES OXIDATIVE STRESS, INFLAMMATION AND CARDIAC DYSFUNCTION IN ACRYLAMIDE- INDUCED CARDIOTOXICITY
Autorzy:
Kushwah, Ajay S.
KALIA, TARANBIR S.
Powiązania:
https://bibliotekanauki.pl/articles/895356.pdf
Data publikacji:
2020-04-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
cardiotoxicity
acrylamide
quercetin
myocardial damage
Opis:
Acrylamide (ACR) is a foodborne toxic agent, formed in food when processed at high temperature. This study aimed at evaluating the biochemical changes induced by ACR and the effect of Quercetin as a treatment against ACR induced cardiotoxicity in rats. Wistar rats of either sex (n=6) were divided into four groups as follows: normal control, an Acrylamide control group, Quercetin groups (25 and 50 mg/kg). Diagnostics characteristics were assessed daily, at the end of the study (4 weeks) evaluate hemodynamic parameters, the blood sample was collect for estimation of biochemical and rats were decapitated excised hearts, cleaned and weighed. Heart homogenate was used to determine antioxidants and oxidative levels, and histopathological evaluations were carried out to determine changes induced by Acrylamide. As compared control groups, ACR treated rats show altered significantly (P < 0.05) general characteristic and also elevated myocardial damage markers, altered hemodynamic, oxidative stress level, increased expression of inflammatory cytokines and induced histopathological changes. Treatment with Quercetin at 25 mg/kg and 50 mg/kg recouped the above changes significantly (P < 0.05), 50 mg/kg being more prominent. The present study has concluded that Quercetin protects against Acrylamide-induced cardiotoxicity.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 2; 343-352
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sperm mitochondrial dysfunction and oxidative stress as possible reasons for isolated asthenozoospermia
Autorzy:
Nowicka-Bauer, K.
Lepczynski, A.
Ozgo, M.
Kamieniczna, M.
Fraczek, M.
Stanski, L.
Olszewska, M.
Malcher, A.
Skrzypczak, W.
Kurpisz, M.K.
Powiązania:
https://bibliotekanauki.pl/articles/70952.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
sperm motility
mitochondrial dysfunction
asthenozoospermia
oxidative stress
reactive oxygen species
proteomics
patient
Źródło:
Journal of Physiology and Pharmacology; 2018, 69, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Oxidative stress and total antioxidant status in term newborns and their mothers
Autorzy:
Wilinska, M.
Borszewska-Kornacka, M.K.
Niemiec, T.
Jakiel, G.
Powiązania:
https://bibliotekanauki.pl/articles/51035.pdf
Data publikacji:
2015
Wydawca:
Instytut Medycyny Wsi
Źródło:
Annals of Agricultural and Environmental Medicine; 2015, 22, 4
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Supervised Physical Exercise on Oxidative Stress in Children with Autism
Autorzy:
Moghadasi, Mehrzad
Arvin, Hamid
Rohbanfard, Hassan
Arsham, Saeed
Ostovar, Alireza
Powiązania:
https://bibliotekanauki.pl/articles/47529705.pdf
Data publikacji:
2024
Wydawca:
Uniwersytet Szczeciński. Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Tematy:
exercise training
oxidative stress
BDNF
malondialdehyde
Autism
Opis:
Background: The etiology of autism spectrum disorders is not well known but oxidative stress has been suggested to play a pathological role. Purpose: The present study aimed to investigate the effects of supervised physical exercise on oxidative stress in children with autism. Methods: Thirty boys with autism (7 to 9 years old) voluntarily participated in this study. They were randomly divided into experimental and control groups. The experimental group performed a physical curriculum known as sports, play and active recreation for kids (SPARK) for 12 weeks (3 sessions of 45 minutes per week), while the control group was exempted to participate in the program. As the clinical parameters, the level of brain-derived neurotrophic factor (BDNF) and malondialdehyde (MDA) were measured before and after the intervention. Results: The results indicated that BDNF levels significantly increased (85.7 %) and MDA concentration significantly decreased (29.2%) in the experimental group (p < 0.05). Conclusions: In conclusion, the supervised physical exercise may result in less oxidative stress in children with autism.
Źródło:
Central European Journal of Sport Sciences and Medicine; 2024, 46; 45-51
2300-9705
2353-2807
Pojawia się w:
Central European Journal of Sport Sciences and Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of barium chloride on growth and oxidative stress of saltwater algae
Autorzy:
Sosnowski, Witold
Drozłowska, Emilia
Powiązania:
https://bibliotekanauki.pl/articles/1162581.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
FTIR
IR spectroscopy
Nannochloropsis
TPC
algae
barium chloride
polyphenolic
toxity
Opis:
Algae have the ability to detoxify the environment by binding heavy metals. They are also used as natural biosensors. In this study, the effect of barium chloride on saltwater algae was examined. Direct influence on the development of the test organism was visualized by means of infrared spectroscopy. The direct effect of barium chloride describes the amount of polyphenols and chlorophyll content in the culture. Work indicates the toxicity scale of a relatively small amount of toxic factor. The results were compared with the effects for a non-barium chloride culture.
Źródło:
World Scientific News; 2018, 111; 121-130
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biochemical markers of oxidative stress in triticale seedlings exposed to cereal aphids
Autorzy:
Lukasik, I.
Golawska, S.
Powiązania:
https://bibliotekanauki.pl/articles/2117824.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
hydrogen peroxide
protein thiols
protein carbonyls
rhopalosiphum padi
sitobion
avenae
triticale
Opis:
In this study, we examined whether and to what extent oxidative stress is induced in seedlings of two winter triti- cale (Triticosecale wittm.) varieties (susceptible Tornado and resistant witon) in response to infestation by the cereal grain aphid (sitobion avenae l.) and bird-cherry-oat aphid (rhopalosiphum padi l.). we compared the level of hydrogen peroxide (H 2O2) and lipid peroxidation products as well as markers of protein damage (protein- bound thiol and carbonyl groups). The studied parameters were measured at 6, 24, 48 and 96 h post-initial aphid infestation compared to the non-infested control seedlings. Our studies indicated that the cereal aphid feeding evoked oxidative stress in the triticale seedlings. Cereal aphid feeding increased the H2O2 level in triticale tissues, with maximum levels observed at 24 and 48 h post-infestation. Triticale infestation with aphids also increased lipid peroxidation products in triticale seedlings, with the maximal levels at 48 or 96 h post-infestation. Further, there was a reduction in protein thiol content and an increase in protein carbonyl content in the triticale seedlings after infestation with female aphids. Stronger triticale macromolecule damages were evoked by the oligophagous aphid r. padi. There was a more substantial protein thiol content reduction in the resistant witon cultivar and higher accumulation of protein-bound carbonyls in the tissues of the susceptible Tornado cultivar. The changes were proportional to the aphid population and the time of aphid attack. These findings indicate that the defensive strategies against cereal aphid (s. avenae and r. padi) infestation were stimulated in triticale Tornado and witon seedlings. Our results explain some aspects and broaden the current knowledge of regulatory mechanisms in plant-aphid interactions.
Źródło:
Acta Biologica Cracoviensia. Series Botanica; 2019, 61, 2; 35-46
0001-5296
Pojawia się w:
Acta Biologica Cracoviensia. Series Botanica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Altered oxidative stress levels in Indian Parkinsons disease patients with PARK2 mutations
Autorzy:
Vinish, Monika
Anand, Akshay
Prabhakar, Sudesh
Powiązania:
https://bibliotekanauki.pl/articles/1039907.pdf
Data publikacji:
2011
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
oxidative stress
mutations
Parkinson's disease
PARK2
Opis:
The aim of this pilot study was to determine the baseline state of oxidative stress indices in patients with Parkinson's disease (PD). Peripheral blood samples of 15 PD subjects were analyzed and compared with ten age matched healthy controls. Patients with PARK2 mutations were also compared with PD patients without mutations. There was significant increase in malondialdehyde content and superoxide-dismutase (SOD) activity in peripheral blood parameters in PD patients (p < 0.05) in comparison to controls. These findings suggest an important role of oxidative stress in Parkinson's disease evolution and progress. No changes were observed in glutathione peroxidase and nitric oxide levels. We found significant correlation between SOD activity and lipid peroxidation when the biochemical data was further analyzed. In addition, significant increase in the levels of SOD among the PD patients with PARK2 mutations was observed, which can be ascribed to chronic oxidative stress induced by PARK2 mutations.
Źródło:
Acta Biochimica Polonica; 2011, 58, 2; 165-169
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of nitric oxide in paraquat-induced oxidative stress in rat striatum
Autorzy:
Djukic, M
Jovanovic, M.C.
Ninkovic, M.
Vasiljevic, I.
Jovanovic, M.
Powiązania:
https://bibliotekanauki.pl/articles/49779.pdf
Data publikacji:
2007
Wydawca:
Instytut Medycyny Wsi
Tematy:
Wistar rat
brain
nitric oxide
paraquat
oxidative stress
pesticide
herbicide
neurotoxicity
exposure
rat
Opis:
The role of nitric oxide (NO) in paraquat (PQ)-induced neurotoxicity is still not fully understood. In this study we used NG-nitro-L-arginine methyl ester (L-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, in order to examine the effects of NO, reactive oxygen species (ROS) generation and lipid peroxidation (LPO) development during PQ-mediated neurotoxicity. Oxidative stress development in the striatum of Wistar rats intrastriatally (i.s.) poisoned with PQ (and in some cases pre-treated with L-NAME) was investigated by measuring superoxide anion (O2 •ˉ), malondialdehyde (MDA) and nitrate (NO3ˉ), 30 min, 24 hours and 7 days after treatment. L-NAME pretreatment provided the possibility to distinguish the role of ROS from reactive nitrogen species (RNS) in oxidative stress development induced by PQ. Our results confi rm the involvement of NO in PQ-mediated neurotoxicity and reduced LPO by L-NAME pretreatment implying that the latter has a protective role.
Źródło:
Annals of Agricultural and Environmental Medicine; 2007, 14, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Basic energetic parameters of Acanthamoeba castellanii mitochondria and their resistance to oxidative stress
Autorzy:
Jarmuszkiewicz, Wieslawa
Antos-Krzeminska, Nina
Drachal-Chrul, Danuta
Matkovic, Karolina
Nobik, Wioletta
Pieńkowska, Joanna
Swida, Aleksandra
Woyda-Ploszczyca, Andrzej
Budzinska, Malgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1040753.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Acanthamoeba castellanii
mitochondria
hydrogen peroxide
oxidative stress
Opis:
The purpose of this study was establishing the basic energetic parameters of amoeba Acanthamoeba castellanii mitochondria respiring with malate and their response to oxidative stress caused by hydrogen peroxide in the presence of Fe2+ ions. It appeared that, contrary to a previous report (Trocha LK, Stobienia O (2007) Acta Biochim Polon 54: 797), H2O2-treated mitochondria of A. castellanii did not display any substantial impairment. No marked changes in cytochrome pathway activity were found, as in the presence of an inhibitor of alternative oxidase no effects were observed on the rates of uncoupled and phosphorylating respiration and on coupling parameters. Only in the absence of the alternative oxidase inhibitor, non-phosphorylating respiration progressively decreased with increasing concentration of H2O2, while the coupling parameters (respiratory control ratio and ADP/O ratio) slightly improved, which may indicate some inactivation of the alternative oxidase. Moreover, our results show no change in membrane potential, Ca2+ uptake and accumulation ability, mitochondrial outer membrane integrity and cytochrome c release for 0.5-25 mM H2O2-treated versus control (H2O2-untreated) mitochondria. These results indicate that short (5 min) incubation of A. castellanii mitochondria with H2O2 in the presence of Fe2+ does not damage their basic energetics.
Źródło:
Acta Biochimica Polonica; 2008, 55, 2; 349-356
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of thiamine uptake and utilization in Candida spp. subjected to oxidative stress
Autorzy:
Wolak, Natalia
Tomasi, Massimo
Kozik, Andrzej
Rapala-Kozik, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1038981.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
vitamin B1
thiamine diphosphate-dependent enzymes
antioxidants
reactive oxygen species
Candida spp.
Opis:
Candida species are associated with an increasing number of life-threatening infections (candidiases), mainly due to the high resistance of these yeast-like fungi to antifungal drugs and oxidative stress. Recently, thiamine (vitamin B1) was found to alleviate stress responses in Saccharomyces cerevisiae; however, thiamine influence on defense systems in pathogenic fungi has never been investigated. The current work was aimed to elucidate the role of thiamine in stress reactions of C. albicans, C. glabrata, C. tropicalis and C. dubliniensis, subjected to hydrogen peroxide treatment. As compared to S. cerevisiae, Candida strains exposed to oxidative stress showed: (i) a much higher dependence on exogenous thiamine; (ii) an increased demand for thiamine diphosphate (TDP) and TDP-dependent enzyme, transketolase; (iii) no changes in gene expression of selected stress markers - superoxide dismutase and catalase - depending on thiamine availability in medium; (iv) a similar decrease of reactive oxygen species (ROS) generation in the presence of thiamine. Moreover, the addition of therapeutic doses of thiamine to yeast culture medium revealed differences in its accumulation between various Candida species. The current findings implicate that the protective action of thiamine observed in S. cerevisiae differs significantly form that in pathogenic Candida strains, both in terms of the cofactor functions of TDP and the effects on fungal defense systems.
Źródło:
Acta Biochimica Polonica; 2015, 62, 3; 445-455
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Occupational health surveillance: pulmonary function testing and oxidative stress among photocopying workers in Pakistan
Autorzy:
Javed, Houda
Ghani, Nadia
Ghani, Natasha
Fatima, Ammara
Powiązania:
https://bibliotekanauki.pl/articles/2162777.pdf
Data publikacji:
2019-07-16
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
Oxidative stress
lipid peroxidation
malondialdehyde
pulmonary function test
toner
photocopying machines
Opis:
Background The photocopying occupation contributes to various health issues in workers. Elevated levels of oxidative stress have been found to be associated with respiratory problems in occupational workers. The intention of the current research is to evaluate the association between the pulmonary function parameters, a biomarker of oxidative stress, and the photocopying occupation in Lahore, Pakistan. Material and Methods The study was performed on a group of photocopying operators (N = 100) and a control group (N = 100). A structured questionnaire was developed to gather the demographic attributes. Lung function testing was done with the spirometer. The blood lipid peroxides level, as thiobarbituric acid reactive substances (TBARS), was assessed spectrophotometrically. Results A statistically significant reduction was found in the pulmonary function parameters as compared to the control group. In the study group, the prevalence of respiratory symptoms, including cough (31%), sneezing (18%), wheezing (9%) and breathing issues (19%), was high as compared to the control group. A significantly higher plasma TBARS concentration was observed in the photocopying workers. A negative correlation prevailed between FVC (−0.081), FVC% predicted (−0.038) and FEV1 (−0.043), and the duration of exposure. Conclusions The study showed that the occupational exposure could have a significant effect on the normal pulmonary function and the oxidative potential of well-being. The profound emissions in the vicinity of photocopying centers may be responsible for the variations in the pulmonary function parameters and oxidative stress. Med Pr. 2019;70(4):403–10
Źródło:
Medycyna Pracy; 2019, 70, 4; 403-410
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rola stresu oksydacyjnego w cukrzycy ciążowej
The role of oxidative stress in gestational diabetes
Autorzy:
Stopińska, Kamila
Marzec, Adrianna
Powiązania:
https://bibliotekanauki.pl/articles/2170102.pdf
Data publikacji:
2023-02-21
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
stres oksydacyjny
reaktywne formy tlenu
cukrzyca ciążowa
oxidative stress
reactive oxygen species
gestational diabetes mellitus
Opis:
Cukrzyca ciążowa (gestational diabetes mellitus – GDM) jest jedną z najczęstszych chorób prowadzących do powikłań w trakcie ciąży. Zauważono, że GDM towarzyszy nasilenie stresu oksydacyjnego. Celem niniejszej pracy jest podsumowanie stanu wiedzy na temat wpływu stresu oksydacyjnego na występowanie i przebieg GDM oraz jej odległe skutki. Przegląd ma także na celu sprawdzenie potencjalnych implikacji klinicznych związanych z GDM. Przeszukano bazy danych takie jak Pubmed, Scopus i Google Scholar. Artykuły wyszukiwano m.in. z użyciem fraz „gestational diabetes mellitus” i „oxidative stress”. Wykazano istotnie wyższy po-ziom stresu oksydacyjnego u kobiet z GDM, zarówno we krwi, jak i w łożysku. Stres oksydacyjny może być ściśle związany z patogenezą GDM. Ze względu na istotną rolę stresu oksydacyjnego w patofizjologii GDM wiele badań skupia się na poszukiwaniu substancji, które mogą zmniejszyć stężenie prooksydantów i zwiększyć udział antyoksydantów, tym samym poprawiając potencjał oksydacyjny. Stres oksydacyjny odgrywa kluczową rolę w patogenezie i patofizjologii GDM. Ponieważ jest to choroba, która może prowadzić do wielu powikłań zarówno u matki, jak i u płodu, jej wczesne wykrycie i skuteczne leczenie wymaga szczególnej uwagi. Ocena możliwości zastosowania parametrów stresu oksydacyjnego jako biomarkerów do wczesnego wykrywania GDM wymaga dalszych szczegółowych badań.
Gestational diabetes mellitus (GDM) is one of the most common diseases that leads to complications during pregnancy. It has been noticed that GDM is accompanied by an increase in oxidative stress. The aim of this study is to summarize the state of knowledge on the influence of oxidative stress on the occurrence and course of gestational diabetes as well as its long-term effects. This review also aims to examine the potential clinical implications of GDM. Databases such as Pubmed, Scopus, and Google Scholar were searched. Articles were searched for using the phrases “gestational diabetes mellitus” and “oxidative stress”. A significantly higher level of oxidative stress was found in women with GDM, both in the blood and in the placenta. Oxidative stress may be closely related to the pathogenesis of GDM. Due to the important role of oxidative stress in the pathophysiology of GDM, many studies have focused on finding substances that can reduce the concentration of prooxidants and increase the proportion of antioxidants, thereby improving the oxidative potential. Oxidative stress plays a key role in the pathogenesis and pathophysiology of GDM. As it is a disease that can lead to a number of complications for both the mother and the fetus, its early detection and effective treatment require special attention. Further detailed research is required to evaluate the possibility of using the parameters of oxidative stress as biomarkers for the early detection of GDM.
Źródło:
Annales Academiae Medicae Silesiensis; 2023, 77, 1; 30-36
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modulation of rutin-mediated alleviation of heavy metal-induced oxidative stress in Zygophyllum fabago
Autorzy:
Ozfidan-Konakci, C.
Yildiztugay, E.
Kucukoduk, M.
Powiązania:
https://bibliotekanauki.pl/articles/79968.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
rutin
reactive oxygen species
antioxidant defense system
Zygophyllum fabago
oxidative stress
heavy metal
antioxidative enzyme
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Fluoride and Bentonite on Biochemical Aspects of Oxidative Stress in Pisum sativum
Autorzy:
Śnioszek, M.
Telesiński, A.
Smolik, B.
Zakrzewska, H.
Powiązania:
https://bibliotekanauki.pl/articles/125180.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
fluoride
bentonite
oxidative stress
antioxidants
Pisum sativum
Opis:
Fluoride is regarded as one of the strongest oxidants, which causes oxidative changes in cells of living organisms. It may both increase the content of reactive oxygen species and inhibit the activity of antioxidative enzyme. In recent years, many researchers successfully used the properties of clay minerals in the sorption of fluoride ion from water. This raises the question of the possibility of limiting the effect of fluorine on the negative changes in plants by adding bentonite to soil. A two-year pot experiment was carried out in the Greenhouse of West Pomeranian University of Technology in Szczecin, on loamy sand and sandy loam. Each sample of soil was mixed with three different concentrations of bentonite – 1, 5, 10% of dry weight (DW) of the soil and then treated with 30 mmol of F- per 1 kg of dry weight of the soil in a form of NaF solution. A control series was prepared for each soil, to which no additives were added. The medium prepared in such way was transferred to plastic pots (3 kg each) and seeded with 16 pea seeds of Pisum sativum. In three phases of pea development (4 leaves unfolded, flowering and development of fruit), fresh leaf samples were collected and the concentrations of ascorbic acid, reduced glutathione, total flavonoids and total polyphenols were measured. Sodium fluoride introduced to the soil changed the level of antioxidant parameters in the plant, which may suggest that fluoride is involved in the formation of reactive oxygen species, resulting in oxidative stress. Bentonite in a dosage of 10% reduced the toxic effects of fluoride on the oxidative balance and morphological changes in the plant, which was observed especially for loamy sand, naturally poor in clay minerals.
Źródło:
Journal of Ecological Engineering; 2018, 19, 2; 164-171
2299-8993
Pojawia się w:
Journal of Ecological Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Selected oxidative stress parameters after single and repeated administration of octabromodiphenyl ether to rats
Autorzy:
Bruchajzer, Elżbieta
Frydrych, Barbara
Kilanowicz, Anna
Sapota, Andrzej
Szymańska, Jadwiga A.
Powiązania:
https://bibliotekanauki.pl/articles/2178893.pdf
Data publikacji:
2014-10-01
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
Oxidative stress
rat
OctaBDE
single and repeated administration
Opis:
Objectives: Octabromodiphenyl ether (OctaBDE) was used as a flame retardant applied mostly in the manufacture of plastics utilized in the electrical and electronic industries. Owing to its long half-life and being regarded as an environmental pollutant, OctaBDE, like other polybrominated diphenyl ethers, has been classified as a persistent organic pollutant (POP). This study was carried out to assess the effects of oxidative stress (redox homeostasis) induced in rats by OctaBDE. Material and Methods: Female Wistar rats exposed intragastrically to OctaBDE at single (25, 200 or 2000 mg/kg b.w.), or repeated (0.4, 2, 8, 40 or 200 mg/kg/day) doses during 7–28 days were used in the experiment. Selected oxidative stress parameters were determined in the liver and blood serum. Results: Administration (single or repeated) of OctaBDE to rats resulted in the impaired redox homeostasis, as evidenced by the increased levels of reduced (GSH) and oxidized (GSSG) glutathione in the liver, the reduced total antioxidant status (TAS) in serum and the increased concentration of malondialdehyde (MDA) in the liver. After multiple doses of OctaBDE, elevated activity of glutathione transferase (GST) in the liver was also noted. Conclusions: After repeated administration of OctaBDE at the lowest dose (0.4 mg/kg/day), changes were observed in the parameters (MDA, TAS, GSSG) indicative of oxidative stress.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2014, 27, 5; 808-820
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cytokine action and oxidative stress response in differentiated neuroblastoma SH-SY5Y cells.
Autorzy:
Kania, Joanna
Barańska, Aleksandra
Guzdek, Amalia
Powiązania:
https://bibliotekanauki.pl/articles/1043437.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
neuroblastoma cells
NFkB
cytokines
PDTC
MnSOD
Opis:
In the retinoic acid-differentiated neuroblastoma SH-SY5Y cells, IL-1 induced binding activity of NFκB and up-regulated the expression and activity of MnSOD. The IL-1-elicited effects were partly reversed by IL-4 and IL-6. It is proposed that IL-4 and IL-6 may participate in the regulation of the imbalanced oxidant status induced by IL-1 in differentiated neuroblastoma cells. In the SH-SY5Y cell line, TNFα neither activated NFκ nor induced MnSOD expression and activity, but was capable of modulating the IL-1 effects. Pyrrolidine dithiocarbamate (PDTC), an inhibitor of NFκB activation, down-regulated the expression and activity of MnSOD, which may suggest that the regulation of MnSOD by IL-1 in retinoic acid-differentiated neuroblastoma cells was mediated by the nuclear factor κB.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 659-666
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł

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