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Tytuł:
The role of immune checkpoint inhibitors in prostate cancer
Autorzy:
Surdacki, G.
Szudy-Szczyrek, A.
Gorący, A.
Chyl-Surdacka, K.
Hus, M.
Powiązania:
https://bibliotekanauki.pl/articles/2082066.pdf
Data publikacji:
2018
Wydawca:
Instytut Medycyny Wsi
Tematy:
prostate cancer
checkpoint inhibitor
PD-1
PD-L1
CTLA-4
Opis:
Introduction. Prostate cancer (PC) is the most commonly diagnosed malignant tumour and the third cause of cancer deaths among men in Europe. The treatment of early-stage PC is very effective and in many cases allows achievement of a complete cure, whereas the treatment of metastatic prostate cancer (mPC) is still a huge challenge for clinicians. New therapeutic strategies for mPC are urgently needded. One of the most promising methods of treatment is anticancer immunotherapy including the monoclonal antibodies against immune checkpoint inhibitors. Objectives. To present the potential possibilities of using checkpoint inhibitors blockage in the treatment of mPC, and to overview the results of recent research on immune checkpoint inhibitors in patients with PC. State of knowledge. Recent studies suggest that monoclonal antibodies directed against immune checkpoint inhibitors in combination with traditional therapy may become a breakthrough in the treatment of mPC in the near future. Conclusions. The immunotherapy using monoclonal antibodies against immune checkpoint inhibitors seems to be a new opportunity for patients with advanced PC. The key to achieve the maximum anti-tumour response is to choose the best candidates for this therapy and determine the optimal sequence and combination of drugs. The introduction of immunotherapy as the standard treatment of patients with advanced PC requires further studies.
Źródło:
Annals of Agricultural and Environmental Medicine; 2019, 26, 1; 120-124
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Znaczenie PD-1 – receptora programowanej śmierci-1 – i jego ligandów w immunoterapii raka jajnika
The role of PD-1 – a programmed cell death receptor 1 – and its ligands in ovarian cancer immunotherapy
Autorzy:
Markowska, Anna
Sajdak, Stefan
Lubin, Jolanta
Markowska, Janina
Powiązania:
https://bibliotekanauki.pl/articles/1030141.pdf
Data publikacji:
2016
Wydawca:
Medical Communications
Tematy:
PD-1/PD-L1
immunotherapy
nivolumab
ovarian cancer
immunoterapia
niwolumab
rak jajnika
Opis:
The immune system plays an important role in both cancer development and destruction. Tumor cells have developed mechanisms to evade an effective immune response. One of these involves the use of immune checkpoint pathways, which modulate the intensity and duration of such responses. There are two immune checkpoint receptors that have been most thoroughly studied: CTLA-4 (cytotoxic T lymphocyte-associated antigen 4) and PD-1 (programmed cell death protein 1 pathway), involved in regulatory T cell responses. The anti-CTLA-4 antibody is used in the treatment of many malignancies, including non-small-cell lung cancer, prostate cancer and melanoma. PD-1 and its ligands, PD-L1 and PD-L2, represent an immune axis protecting cancer cells against regulatory T cells (cytotoxic CD8+ cells and CD4+ helper cells). Nivolumab, a monoclonal antibody, blocks PD-1 and, as a result, its binding to its ligands. Consequently, T cell antitumor activity is restored, which appears promising in clinical trials involving patients with malignancies in multiple locations, including non-small-cell lung cancer, melanoma and ovarian cancer, clear cell ovarian carcinoma in particular. Nivolumab therapy is not devoid of adverse effects, which affect about 40% of patients with ovarian cancer. These include e.g. arrhythmia, fever, anemia and decreased lymphocyte count. It is believed that combining a therapy that blocks the key immune checkpoints with other anticancer agents, including chemotherapy, radiation therapy or other targeted therapies, will improve treatment efficacy in malignancies, including ovarian cancer.
Układ immunologiczny odgrywa istotną rolę zarówno w rozwoju raka, jak i jego destrukcji. Komórki nowotworu wykształciły mechanizmy pozwalające im uniknąć skutecznej reakcji immunologicznej. Jednym z nich jest wykorzystanie szlaków immunologicznych punktów kluczowych (immune checkpoint), które modulują nasilenie i czas trwania tej odpowiedzi. Najlepiej poznane są dwa receptory immunologicznych punktów kluczowych: antygen 4 CTLA (cytotoxic T lymphocyteassociated antigen 4) i białko programowanej śmierci komórki 1 – PD-1 (programmed cell death protein 1 pathway), uczestniczące w odpowiedzi regulatorowych limfocytów T. Przeciwciało przeciwko cząsteczce CTLA-4 stosowane jest w leczeniu wielu nowotworów złośliwych, w tym niedrobnokomórkowego raka płuca, raka prostaty i czerniaka. PD-1 i jego ligandy PD-L1 i PD-L2 stanowią oś immunologiczną, która chroni komórki nowotworowe przed działaniem limfocytów T regulatorowych (T cytotoksycznych CD8+ i pomocniczych CD4+). Przeciwciało monoklonalne niwolumab blokuje PD-1, a przez to połączenie z jego ligandami. W ten sposób odtwarzana jest aktywność przeciwguzowa limfocytów T, która okazuje się obiecująca w próbach klinicznych u chorych na nowotwory złośliwe w wielu lokalizacjach, w tym na niedrobnokomórkowego raka płuca, czerniaka oraz raka jajnika, zwłaszcza jasnokomórkowego. Stosowanie niwolumabu nie jest pozbawione działań niepożądanych, które występują u około 40% leczonych na raka jajnika kobiet. Należą do nich między innymi arytmia, gorączka, niedokrwistość oraz obniżenie liczby limfocytów. Uważa się, że łączenie terapii blokującej kluczowe punkty immunologiczne z innymi czynnikami przeciwrakowymi, w tym chemioterapią, radioterapią, inną terapią celowaną, pozwoli uzyskać większą skuteczność w leczeniu nowotworów złośliwych, w tym raka jajnika.
Źródło:
Current Gynecologic Oncology; 2016, 14, 2; 117-120
2451-0750
Pojawia się w:
Current Gynecologic Oncology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Exposure at default. The problem of its estimation in the context of capital requirements
Autorzy:
Siarka, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/584988.pdf
Data publikacji:
2014
Wydawca:
Wydawnictwo Uniwersytetu Ekonomicznego we Wrocławiu
Tematy:
credit risk
EAD
PD
LGD
Opis:
Credit risk analysis is largely based on the principles set out by the Basel Committee. Next to the probability of default and recovery rate, one of the most important elements of risk management systems is the value of the exposure at default. This paper presents the issue of EAD (Exposure at Default) estimation with respect to both balance sheet and off-balance sheet items. The author refers to the problem regarding the assessment of EAD forecast quality. He presents the results of the simulations conducted for the most common retail portfolios. The results show that the expected value of the exposure at default is significantly lower than the balance value at the moment of capital requirement calculation. This leads to the conclusion that the approach recommended by the Basel Committee, based on the current book value of the exposure, may result in the overestimation of EAD. The paper contains the proposal of the method which was leveraged for retail products (cash loans, car loans, mortgage loans).
Źródło:
Mathematical Economics; 2014, 10(17); 61-78
1733-9707
Pojawia się w:
Mathematical Economics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determination of dosimetry parameters of ADVANTAGETM 103Pd brachytherapy seed using MCNP4C computer code
Autorzy:
Ataeinia, V.
Raisali, G.
Sadeghi, M.
Powiązania:
https://bibliotekanauki.pl/articles/148136.pdf
Data publikacji:
2009
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
brachytherapy
103Pd source
dosimetry parameters
MCNP4C
ADVANTAGE TM 103Pd
Opis:
The IsoAid LLC Inc. has been introduced ADVANTAGETM 103Pd brachytherapy seed in 2006. The aim of this work is to determine the dosimetric characteristics of this seed according to AAPM’s recommendation in TG43-U1 using MCNP4C computer code. The dose rate constant has been determined to be 0.694š0.001 cGy.h–1.U–1. The radial dose function has been calculated at distances from 0.25 to 7 cm. Two-dimensional anisotropy function have been calculated at distances from 0.25 to 7 cm and at angles from 0 to 90 degrees centigrade at 10 degrees centigrade increments. The one-dimensional anisotropy function and anisotropy constant have been also calculated. The anisotropy constant in water has been calculated as 0.872š0.001. The results of this investigation are compared with the results of Meigooni et al. obtained by PTRAN code in 2006 and Sowards results obtained by PTRAN code in 2007. The comparison of the dose rate constant and the one-dimensional anisotropy function obtained from the two codes shows good agreement; also the radial dose function at distances lower than 3 cm and the two-dimensional anisotropy function at angles greater than 20 degrees centigrade are in good agreement. But, for the calculated radial dose function at distances beyond 3 cm, we observed differences between our values and Meigooni et al. and Sowards results. Also, differences between the calculated two-dimensional anisotropy function using the two codes for angles smaller than 20 degrees centigrade are considerable. The differences between the results of MCNP4C and PTRAN codes could be related to the different cross-section data libraries used in these two codes.
Źródło:
Nukleonika; 2009, 54, 3; 181-187
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Palladium Catalyst in the HBIW Hydrodebenzylation Reaction. Deactivation and Spent Catalyst Regeneration Procedure
Autorzy:
Maksimowski, P.
Gołofit, T.
Tomaszewski, W.
Powiązania:
https://bibliotekanauki.pl/articles/358843.pdf
Data publikacji:
2016
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
HBIW hydrodebenzylation
palladium-based catalyst
Pd/C deactivation
spent Pd/C catalyst regeneration
Opis:
The polycyclic nitramine 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12- hexaazaisowurtzitane (HNIW, CL-20) is synthesized via hydrodebenzylation of 2,4,6,8,10,12-hexabenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (HBIW) over a palladium-based catalyst. This process is the key step in the synthesis of CL-20, a compound with unique energetic and explosive characteristics. The use of CL-20 is restricted at present by the high cost of the hydrodebenzylation process, during which the palladium-based catalyst becomes rapidly deactivated. The catalyst deactivation has now been shown to consist of deposition of the reaction products on the carbon support with simultaneous blocking of the active centers by these products. The HBIW decomposition products can permanently combine with palladium, thereby reducing the number of the active centers on the catalyst. Other byproducts clog the pores of the active carbon and reduce both the surface area of the active carbon and the pore volume. The reaction yield is also reduced by aggregation of palladium particles. A palladium catalyst regeneration procedure which has now been developed, consists of heating the catalyst for a specific time at 350 °C in a nitrogen and water vapour stream, and allows partial recovery of the activity of the palladium catalyst in a subsequent HBIW hydrodebenzylation reaction. The specific area and overall pore volume of the regenerated catalyst are also enhanced. The yield from the HBIW hydrodebenzylation reaction using the regenerated catalyst was ca. 42%.
Źródło:
Central European Journal of Energetic Materials; 2016, 13, 2; 333-348
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Annealing time effects on the surface morphology of C–Pd films prepared on silicon covered with SiO2
Autorzy:
Kozlowski, M.
Radomska, J.
Wronka, H.
Czerwosz, E.
Firek, P.
Sobczak, K.
Dluzewski, P.
Powiązania:
https://bibliotekanauki.pl/articles/949412.pdf
Data publikacji:
2013
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
Pd
carbon
film
SEM
TEM
Opis:
Morphology changes of C–Pd films prepared in physical vapor deposition (PVD) process and next annealed in a temperature of 650 °C during different time were studied. These studies were performed with electron microscopy methods (scanning SEM and transmission TEM). It was found that not annealed films are flat and they are composed of grains with composite character and size of 100–200 nm. Pd nanocrystallite of a diameter of a few nanometers in some carbon matrix was placed in these grains. For annealed films, a formation of palladium nanograins with different sizes and shapes as well as a porous carbon matrix were observed. High resolution TEM investigation was used to determine a structure of all these grains. An increase in duration time of annealing process led to diminishing of the porosity of carbon matrix and a number of Pd grains situated on the film surface. It was also stated that covering of Si with SiO2 layer prevents formation of palladium silicide.
Źródło:
Optica Applicata; 2013, 43, 1; 81-89
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adaptive fuzzy-sliding mode controller for trajectory tracking control of quad-rotor
Autorzy:
Simoud, Lahcen
Kadri, Boufeldja
Bousserhane, Ismail Khalil
Powiązania:
https://bibliotekanauki.pl/articles/384825.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Przemysłowy Instytut Automatyki i Pomiarów
Tematy:
quadrotor UAV
sliding mode control
adaptive PD-Slidng mode controller
fuzzy PD-sliding mode
Opis:
This paper deals with the design of an adaptive-fuzzy-PD-Sliding mode controller to achieve stabilization of a quadrotor aircraft in the presence of wind disturbance. Firstly, the dynamic system modeling is carried out using Euler-Lagrange formalism. Then, an adaptive PD-sliding mode control system with an integral-operation switching surface is investigated for quadrotor desired trajectory tracking. Finally, an adaptive fuzzy-PD-sliding mode controller is proposed to achieve control objectives and system stabilization where the fuzzy logic system used to dynamically control parameters settings of the PD-sliding mode equivalent control law. Effectiveness and robustness of the proposed control scheme is verified through simulation results taking into account external disturbances. The simulation results of a quadrotor aircraft control with the proposed controller demonstrate the high performance during flight such as null tracking error and robustness in the presence of external disturbances.
Źródło:
Journal of Automation Mobile Robotics and Intelligent Systems; 2020, 14, 2; 15-24
1897-8649
2080-2145
Pojawia się w:
Journal of Automation Mobile Robotics and Intelligent Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface and Thin Film Magnetization of Isotropic and Anisotropic Heisenberg Ferromagnet at Low Temperatures
Autorzy:
Modrak, P.
Powiązania:
https://bibliotekanauki.pl/articles/1968931.pdf
Data publikacji:
1998-05
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
75.70.Ak
75.30.Pd
Opis:
The independent random walk method (which is equivalent to the noninteracting spin wave method) with no further approximations was used to calculate the low temperature expansion of: (i) the local mean spin values of an isotropic Heisenberg ferromagnet for semi-infinite crystal and (ii) the spontaneous magnetization of an anisotropic Heisenberg ferromagnet for monolayer and double layer. The full low temperature expansion starting with T$\text{}^{3}\text{}^{/}\text{}^{2}$ term was obtained for the semi-infinite Heisenberg ferromagnet and it was shown that the spontaneous magnetization for thin films of anisotropic Heisenberg ferromagnets can exhibit a quasi-linear behaviour in certain temperature region related to the magnitude of the anisotropy.
Źródło:
Acta Physica Polonica A; 1998, 93, 5-6; 785-797
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impulse identification and discrete P/PD control of electro-hydraulic servodrive
Autorzy:
Możaryn, Jakub
Winnicki, Arkadiusz
Suski, Damian
Powiązania:
https://bibliotekanauki.pl/articles/384417.pdf
Data publikacji:
2018
Wydawca:
Sieć Badawcza Łukasiewicz - Przemysłowy Instytut Automatyki i Pomiarów
Tematy:
PD controller
identification for control
analytic design
identification
control methods
kontroler PD
identyfikacja
metody kontroli
Opis:
This article presents the systematic design methodology of a discrete Proportional and Proportional-Derivative (PD) controller for the electro-hydraulic servodrive position control. The controller is based on the identified linear model of the system, with P/PD parameters adjusted with the help of different methods given in the literature. There are compared experimental results of the proposed control system with different controller parameters.
Źródło:
Journal of Automation Mobile Robotics and Intelligent Systems; 2018, 12, 4; 51-57
1897-8649
2080-2145
Pojawia się w:
Journal of Automation Mobile Robotics and Intelligent Systems
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of heat transfer parameters on rhodium target for 103Pd production
Autorzy:
Sadeghi, M.
Tenreiro, C.
Van den Winkel, P.
Powiązania:
https://bibliotekanauki.pl/articles/148100.pdf
Data publikacji:
2009
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
heat transfer
103Pd
rhodium
target
Opis:
The efficiency of cooling and the particle beam characteristics are important when high beam current irradiations are intended for production of radionuclides. The efficiency of cooling is determined by both the target carrier geometry and the flow rate of coolant, while the beam characteristics deal with the current density distribution on the irradiated surface area. Heat transfer on rhodium target to produce 103Pd via the 103Rh(p,n)103Pd reaction was investigated and the beam current was obtained more than 500 mi A.
Źródło:
Nukleonika; 2009, 54, 3; 169-173
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular analysis of three novel G6PD variants: G6PD Pedoplis-Ckaro, G6PD Piotrkow and G6PD Krakow
Autorzy:
Maciag, Monika
Plochocka, Danuta
Jablonska-Skwiecinska, Ewa
Mendek-Czajkowska, Ewa
Golaszewska, Ewa
Strojny, Wojciech
Balwierz, Walentyna
Zdebska, Ewa
Burzynska, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1040891.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
G6PD deficiency
molecular modeling
Opis:
We present three novel mutations in the G6PD gene and discuss the changes they cause in the 3-dimensional structure of the enzyme: 573C→G substitution that predicts Phe to Leu at position 191 in the C-terminus of helix αe, 851T→C mutation which results in the substitution 284Val→→Ala in the β+α domain close to the C-terminal part of helix αj, and 1175T→C substitution that predicts Ile to Thr change at position 392.
Źródło:
Acta Biochimica Polonica; 2007, 54, 4; 877-881
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface Magnetostriction within Néels Model
Autorzy:
Żuberek, R.
Żymierska, D.
Szymczak, H.
Powiązania:
https://bibliotekanauki.pl/articles/1930607.pdf
Data publikacji:
1994-02
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
75.30.Pd
75.70.Cn
Opis:
The aim of the present paper is to determine the surface magnetostriction in the spirit of Néel's model of the surface magnetic anisotropy. Calculations have been performed for bcc and fcc ferromagnetic crystals.
Źródło:
Acta Physica Polonica A; 1994, 85, 2; 439-442
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Statistical Optimization of a Novel Approach for the Reductive Debenzylation of 2,4,6,8,10,12-Hexabenzyl-2,4,6,8,10,12-hexaazaisowurtzitane Using Pd@SiO2 Nano Catalyst
Autorzy:
Zarandi, M.
Bayat, Y.
Zebardasti, A.
Khayrabadi, A. A.
Powiązania:
https://bibliotekanauki.pl/articles/358766.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
Pd@SiO2
reductive debenzylation
nano
catalyst
Taguchi
Opis:
The synthesis of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazaisowurtzitane (TADB), from 2,4,6,8,10,12-hexabenzyl-2,4,6,8,10,12-hexaazaisowurtzitane(HBIW) is a key step in the preparation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (HNIW or CL-20). In this study, a novel highly efficient nano catalyst based on Pd@SiO2 was used for the reductive debenzylation of HBIW. It is notable that an orthogonal array design OA9 was applied as a statistical optimization method for the synthesis of TADB. The current application of the Taguchi method in optimizing the experimental parameters of the TADB synthetic procedure was successful. TADB was synthesized by investigating the effect of the reaction conditions, such as catalyst percentage, time (h) and temperature (°C). The effects of these factors on the yield of TADB were evaluated quantitavely by the analysis of variance (ANOVA). The Pd@SiO2 nano catalyst, consisting of a palladium core with SiO2 monolayer shells, was synthesized and characterized by SEM, TEM and IR spectroscopy. The optimum condition indicated that the use of fresh Pd@SiO2 nano catalyst provides a high yield (90%). The use of Pd@SiO2 nano catalyst after recovery gave a yield of 65%.
Źródło:
Central European Journal of Energetic Materials; 2017, 14, 4; 984-995
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The algorithm of adaptive determination of amplification of the PD filter estimating object state on the basis of signal measurable on-line
Autorzy:
Kwater, Tadeusz
Hawro, Przemysław
Bartman, Jacek
Mazur, Damian
Powiązania:
https://bibliotekanauki.pl/articles/1409165.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
estimation
Kalman filter
adaptive PD filter
filter amplification
Opis:
The article presents the algorithm that enables adaptive determination of the amplification coefficient in the filter equation provided by Kalman. The method makes use of an estimation error, which was defined for this purpose, and its derivative to determine the direction of correction changes of the gain vector. This eliminates the necessity to solve Riccati equation, which causes reduction of the method computational complexity. The experimental studies carried out using the proposed approach relate to the estimation of state coordinates describing river pollution using the BOD (biochemical oxygen demand) and DO (dissolved oxygen) indicators).The acquired results indicate that the suggested method does better estimations than the Kalman filter. Two indicators were used to measure the quality of estimates: the Root Mean Squared Error (RMSE) and the Mean Percentage Error (MPE).
Źródło:
Archives of Control Sciences; 2021, 31, 1; 129-143
1230-2384
Pojawia się w:
Archives of Control Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Robotic swarm self-organisation control
Autorzy:
Hendzel, Zenon
Wiech, Jakub
Powiązania:
https://bibliotekanauki.pl/articles/387481.pdf
Data publikacji:
2019
Wydawca:
Politechnika Białostocka. Oficyna Wydawnicza Politechniki Białostockiej
Tematy:
swarm robotics self-organization
PD controller
nonholonomic robots
Opis:
This article proposes a new swarm control method using distributed proportional-derivative (PD) control for self-organisation of swarm of nonholonomic robots. Kinematics control with distributed proportional-derivative (DPD) controller enables generation of desired robot trajectory achieving collective behaviour of a robotic swarm such as aggregation and pattern formation. Proposed method is a generalisation of virtual spring-damper control used in swarm self-organisation. The article includes the control algorithm synthesis using the Lyapunov control theory and numeric simulations results.
Źródło:
Acta Mechanica et Automatica; 2019, 13, 2; 130-134
1898-4088
2300-5319
Pojawia się w:
Acta Mechanica et Automatica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Motor assessment in Parkinson`s disease
Autorzy:
Opara, Józef A.
Małecki, Andrzej
Małecka, Elżbieta
Socha, Teresa
Powiązania:
https://bibliotekanauki.pl/articles/991125.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
parkinson`s disease
pd
balance
gait
posture
posturometry
Opis:
Parkinson’s disease (PD) is one of most disabling disorders of the central nervous system. The motor symptoms of Parkinson’s disease: shaking, rigidity, slowness of movement, postural instability and difficulty with walking and gait, are difficult to measure. When disease symptoms become more pronounced, the patient experiences difficulties with hand function and walking, and is prone to falls. Baseline motor impairment and cognitive impairment are probable predictors of more rapid motor decline and disability. An additional difficulty is the variability of the symptoms caused by adverse effects of drugs, especially levodopa. Motor assessment of Parkinson`s Disease can be divided into clinimetrics, assessment of balance and posture, arm and hand function, and gait/walking. These are many clinimetric scales used in Parkinson`s Disease, the most popular being the Hoehn and Yahr stages of progression of the disease and Unified Parkinson’s Disease Rating Scale. Balance and posture can be assessed by clinimetric scales like the Berg BS, Tinetti, Brunel BA, and Timed Up and Go Test, or measured by posturometric platforms. Among skill tests, the best known are: the Purdue Pegboard Test, Nine-Hole Peg Test, Jebsen and Taylor test, Pig- Tail Test, Frenchay Arm Test, Action Research Arm Test, Wolf FMT and Finger-Tapping Test. Among motricity scales, the most popular are: the Fugl-Meyer Motor Assessment Scale and Södring Motor Evaluation. Gait and walking can also be assessed quantitatively and qualitatively. Recently, the most popular is three-dimensional analysis of movement. This review article presents the current possibilities of motor assessment in Parkinson`s disease.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of palladium chemical structure on hydrogen sensing properties of carbonaceous–palladium thin films
Autorzy:
Kaminska, A.
Krawczyk, S.
Kozlowski, C.
Powiązania:
https://bibliotekanauki.pl/articles/173783.pdf
Data publikacji:
2013
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
C–Pd thin films
hydrogen sensor
FTIR spectroscopy
Opis:
In this work we investigate nanocomposite carbonaceous–palladium (C–Pd) films prepared by physical vapor deposition. Such films are promising materials for hydrogen sensor applications. This is related to the highly selective hydrogen absorption by palladium nanocrystallites. The C–Pd films obtained in various technological conditions differ in structure and electrical properties. These films were characterized by SEM, EDS and FTIR spectroscopy. FTIR spec-troscopy was used to determine the amount of palladium acetate and fullerene, incompletely decomposed during the deposition process. FTIR spectra enabled us to explain the differences in C–Pd films resistance based on palladium chemical structure. The possibility of the application of C–Pd films as active layers in hydrogen sensors was also studied. The results showed that synthesized C–Pd films containing palladium nanograins could be used for hydrogen sensing.
Źródło:
Optica Applicata; 2013, 43, 4; 633-640
0078-5466
1899-7015
Pojawia się w:
Optica Applicata
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surface Magnetostriction
Autorzy:
Szymczak, H.
Żuberek, R.
Powiązania:
https://bibliotekanauki.pl/articles/1929324.pdf
Data publikacji:
1993-05
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
75.30.Pd
75.50.Rr
75.70.Cn
Opis:
Experimental and theoretical research on magnetostriction of nanoscale magnetic multilayers is reviewed. The importance of interfaces and the occurrence of the surface magnetostriction is emphasized. It is shown that the dependence of magnetostriction on the magnetic layer thickness is due to the magnetostrictive strains localized at the interface.
Źródło:
Acta Physica Polonica A; 1993, 83, 5; 651-659
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The Improvement of Atomic Force Microscope Suitable for Magnetic Domain Structure Measurements
Autorzy:
Sveklo, I.
Dobrogowski, W.
Kisielewski, M.
Maziewski, A.
Powiązania:
https://bibliotekanauki.pl/articles/2013164.pdf
Data publikacji:
2000-03
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
75.70.-i
75.30.Pd
61.16.Ch
Opis:
Based on commercial Burleigh METRIS$\text{}^{TM}$-2000 Atomic Force Microscope two methods of magnetic force measurements were realised. The developed system was successfully applied for study of magnetic structure of both YIG-garnet and CoNi/Pt magneto-optic multilayers.
Źródło:
Acta Physica Polonica A; 2000, 97, 3; 527-530
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
G6PD Activity in Malaria Infected Children in Owerri
Autorzy:
Ihenetu, Francis C.
Nwachukwu, Michael I.
Ohalete, Chinyere N.
Njoku-Obi, Treasure Njideka
Nwachukwu, Ogechi I.
Okoro, Chinyere I.
Okereke, Bright Chinemerem
Ihenetu, Stanley Chukwuemeka
Powiązania:
https://bibliotekanauki.pl/articles/1113925.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Children
G6PD
Malaria
Plasmodium falciparum
Plasmodium malarae
Opis:
This paper is a study of G6PD activity in malaria-infected children in Owerri. Blood samples were collected from fifty-one (51) children hospitalized in the Federal Medical Center (FMC) and analyzed using standard Medical Laboratory methods. Results revealed that out of the 51 children examined (26 males and 25 females), 39, representing 76.47% of the total malaria infected children numbers, were G6PD deficient, while 12, representing 23.53%, had normal G6PD. Two different plasmodium species and their percentage occurrences were observed. These were: Plasmodium falciparum (78.43%) and Plasmodium malariae (21.57%). The work indicated that male children were more (P < 0.05) deficient than females, with percentage levels of 61.53% and 38.47%, respectively. In addition, children between the ages of 49-60 months was observed to be more (P < 0.05) G6PD deficient (with percentage of 25.64%), while those between 0-12 months were least G6PD deficient (with percentage of 8.3% (P < 0.05)). As being afflicted with malaria carries a high risk of Glucose-6-phosphate dehydrogenase (G6PD) deficiency in children, there is, therefore, urgent need for public enlightenment on public health implications, need for proper hygiene, as well as a need for strategies for preventing and controlling mosquito populations
Źródło:
World News of Natural Sciences; 2017, 12; 63-72
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
IINS, MIR, and DFT Investigations of Vibrational Spectra of 3,3-Dimethyl-1-Butanol and 3,3-Dimethyl-2-Butanol
Autorzy:
Juszyńska, E.
Hołderna-Natkaniec, K.
Massalska-Arodź, M.
Natkaniec, I.
Ściesińska, E.
Ściesiński, J.
Powiązania:
https://bibliotekanauki.pl/articles/1813169.pdf
Data publikacji:
2008-04
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
71.15.Pd
78.70.Nx
33.20.Ea
Opis:
Molecular vibrational spectra in 3, 3-dimethyl-1-butanol, $(CH_3)_3$ $CCH_2CH_2OH$, and 3, 3-dimethyl-2-butanol, $(CH_3)_3CCHOHCH_3$, were measured by the inelastic incoherent neutron scattering and mid infrared spectroscopy and for 3, 3-dimethyl-2-butanol additionally by the far infrared absorption method. Experimental results were discussed and compared with the results of the quantum chemical calculations performed by the density functional theory (DFT/B3LYP/6-311G**) and semi-empirical PM3 calculation methods assuming the isolated molecule approximation.
Źródło:
Acta Physica Polonica A; 2008, 113, 4; 1131-1143
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Infiuence of Hydrogen on the Properties of Nanostructured C-Pd Films for Sensing Applications
Autorzy:
Kamińska, A.
Diduszko, R.
Krawczyk, S.
Czerwosz, E.
Sobczak, K.
Powiązania:
https://bibliotekanauki.pl/articles/778287.pdf
Data publikacji:
2014
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
C-Pd films
hydrogen sensor
GIXD measurements
resistance changes
Opis:
In this paper we present the results of the investigations of nanostructured C-Pd films for hydrogen sensing applications. These C-Pd films were prepared by physical vapor deposition and then annealed in an argon flow at the temperature of 500°C. The structure and morphology of the prepared C-Pd films were investigated using transmission electron microscopy and energy dispersive X-ray spectroscopy. We studied the infiuence of hydrogen on the electrical properties and crystal structure of C-Pd films. It was shown that film resistance changes depended on hydrogen concentration. At lower hydrogen concentration (up to 2 vol.%), the films response increased proportionally to [H2], while above 2 vol.% H2, it was almost constant. This is connected with the formation of a solid solution of hydrogen in palladium at lower H2 concentration and the creation of palladium hydride at higher H2 concentration. X-ray diffraction was used to confirm the formation of Pd-H solid solution and palladium hydride.
Źródło:
Polish Journal of Chemical Technology; 2014, 16, 2; 77-81
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Brazing of selected heat-resisting alloys using Ni-Pd filler metal
Lutowanie twarde wybranych stopów żaroodpornych z zastosowaniem lutu Ni-Pd
Autorzy:
Baranowski, Michał
Senkara, Jacek
Powiązania:
https://bibliotekanauki.pl/articles/115053.pdf
Data publikacji:
2019
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
lutowanie próżniowe
lutowanie twarde
lut Ni-Pd
stop żaroodporny
struktura
złącze
vacuum brazing
Ni-Pd filler metal
heat-resisting alloy
structure
joint
Opis:
Pd is a component of some advanced nickel filler metals designed for brazing heat-resisting alloys in order to improve their wettability and to enhance both corrosion resistance and plasticity of the joints. The joints of Inconel 625, Inconel 718, Hastelloy X, and 410 martensitic stainless steel were prepared by vacuum brazing with NiPd36Cr10BSi filler alloy. Complex structures of the joints were tested. It was revealed the displacement of interfaces from their initial positions in the course of brazing along with active action of Cr, Mo and Nb (for Inconel 718 alloy) in the formation of interstitial layers.
Pallad jest głównym składnikiem niektórych zaawansowanych lutów niklowych, przeznaczonych do lutowania twardego stopów żaroodpornych w celu poprawy ich zwilżalności oraz zwiększenia zarówno odporności na korozję jak i plastyczności połączeń. Wykonane zostały złącza stopów Inconel 625, Inconel 718, Hastelloy X i martenzytycznej stali nierdzewnej 410 metodą lutowania próżniowego stopem NiPd36Cr10BSi. Badano złożone struktury połączeń, ujawniając przesunięcie granic międzyfazowych z ich początkowych pozycji w trakcie lutowania oraz aktywne oddziaływanie Cr, Mo oraz Nb (dla stopu Inconel 718) podczas tworzenia się warstw przejściowych.
Źródło:
Welding Technology Review; 2019, 91, 10; 51-58
0033-2364
2449-7959
Pojawia się w:
Welding Technology Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Invasive vs. Non-Invasive Methods in Estimating Slope Stability, with Application in the Copou Area, Iaşi, Romania
Autorzy:
Pascariu, F.
Negru, C.
Şaramet, M.
Chelariu, C.
Powiązania:
https://bibliotekanauki.pl/articles/1401973.pdf
Data publikacji:
2015-08
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
91.30.pd
91.62.Ty
92.40.Ha
Opis:
Slope stability analysis represents nowadays a constant pursuit, being applied in various domains, such as geological and geomorphological studies, civil engineering or urban expansion. In this paper, two different methods were employed in order to establish the stability of the Copou Hill, Iaşi, Romania, and the results were compared. The first, non-invasive, method involves obtaining a landslide risk map by identifying the factors that induce the slope failure and overlaying the obtained maps. The second one, invasive, implies computing a safety factor using the infinite slope method, employing well data from this area and ranging the thickness of the water column. This comparison was made in order to improve the non-invasive method, so as to apply it in areas where there is no geological information. The resulting landslide risk map shows values of the average coefficient Kₘ ranging between 0.21 and 0.63, implying a medium to high failure probability for the studied slope. On the other hand, the infinite slope method indicates a safety factor with values between 0.91 and 1.49, at a complete flooding of the land-sliding lithological column, with a single exception with much lower value. These values are below the admissible factor, suggesting failure with a medium to high probability. Comparing these two methods, significant similarities between the landslide risk map results and the computed safety factors can be observed. For further testing of the first method, similar studies should also be made in other areas.
Źródło:
Acta Physica Polonica A; 2015, 128, 2B; B-193-B-196
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Simulation of Positron Annihilation Response to Mechanical Deformation of Nanostructured AgCo
Autorzy:
Melikhova, O.
Kuriplach, J.
Čížek, J.
Procházka, I.
Hou, M.
Pisov, S.
Zhurkin, E.
Powiązania:
https://bibliotekanauki.pl/articles/1812541.pdf
Data publikacji:
2008-05
Wydawca:
Polska Akademia Nauk. Instytut Fizyki PAN
Tematy:
78.70.Bj
71.15.Pd
61.46.Hk
Opis:
Nanostructured materials attract nowadays a broad attention due to their specific properties. Defects play an essential role in material properties so their characterisation is very important. The evolution of the various open volume defects in AgCo nanowire modelled samples obtained using molecular dynamics was studied. Isothermal and isoenergetic deformation mechanisms are considered. General analyses of open volume defects concerning their size and their chemical environment were performed. Positron lifetimes, binding energies, and high momentum parts of the momentum distribution of annihilationγ-quanta were calculated for selected defects.
Źródło:
Acta Physica Polonica A; 2008, 113, 5; 1455-1464
0587-4246
1898-794X
Pojawia się w:
Acta Physica Polonica A
Dostawca treści:
Biblioteka Nauki
Artykuł
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