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    Wyświetlanie 1-11 z 11
    Tytuł:
    Application of chitosan in the formulation of dermatological hydrogels prepared on the basis of macromolecular compounds
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Karolewicz, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1034450.pdf
    Data publikacji:
    2018
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    hydrogels
    rheological parameters
    Opis:
    The effect of chitosan concentration on the properties of dermatological preparations prepared with 2% methylcellulose and 10% polyvinylpyrrolidone was studied. As the levels of chitosan, propylene glycol-1,2 and glycerol increased, the hardness, consistency and cohesiveness of the hydrophilic gels increased, while the dissipation capacity decreased. Gels based on methylcellulose and chitosan, compared to formulations containing polyvinylpyrrolidone, have a higher rate of loss of volatile compounds, higher pH values for 1,2-propylene glycol formulation and higher texture parameters. The tested hydrogels have good rheological properties, allowing extrusion from the tube and spreading on the skin.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2018, 23; 179-184
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of chitosan in the formulation of hydrogels applied on skin
    Autorzy:
    Meler, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1035198.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    hydrocortisone
    hydrogels
    pharmaceutical availability
    Opis:
    These studies concerned the effect of composition on the substrate physicochemical parameters of hydrogels for use on skin. Hydrogels containing 1% of hydrocortisone and 1% of chitosan addition was made on the basis of methylcellulose, sodium carboxymethylcellulose and Carbopol 934 P. The release proceeds according to first-order kinetics. Depending on the type and composition of the polymer gels were obtained with various pharmaceutical availability of hydrocortisone. Addition of 1% chitosan affects the acceleration of the release in any given case.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 181-186
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Rheological aspects of the flow of thermosensitive chitosan systems during injection application
    Autorzy:
    Rył, Anna
    Owczarz, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1034161.pdf
    Data publikacji:
    2020
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan scaffolds
    injectability
    thermosensitive hydrogels
    Opis:
    The aim of this paper was to conduct preliminary instrumental tests to determine the possibility of injection applications for thermosensitive chitosan systems, including injection needles and application conditions. Among the many biomedical and pharmaceutical applications of chitosan, the minimally invasive thermosensitive scaffolds that form in vivo are an interesting solution. Despite many studies on colloidal chitosan systems undergoing sol-gel phase transition, almost no studies have examined their injectability. It has been stated that the use of acetic acid as a solvent reduces the forces needed for injection. Moreover, the key impact of injection temperature was determined. Storing the medium at room temperature before the injectability test led to a decrease in the value of forces needed for injection. The obtained results are discussed based on the change of the rheological properties of the chitosan hydrogels.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 201-209
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of selected polymers on the rheological properties of hydrogels with chitosan applied on the skin
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Karolewicz, Bożena
    Powiązania:
    https://bibliotekanauki.pl/articles/1034591.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    hydrogels
    pharmaceutical availability
    rheological parameters
    Opis:
    The aim of the study was to evaluate the effect of methylcellulose and carboxymethylcellulose on the rheological properties of hydrogels applied to skin on chitosan in the presence of the additives propylene glycol and glycerol. Rheological studies showed that the tested gels are non-newtonian systems, and have thixotropic properties. Substrates made of methylcellulose and chitosan are characterised by higher shear values than those obtained with carboxymethylcellulose. The addition of polymers had a positive influence on the dispersion of hydrogels, and the addition of excipients increased firmness, consistency and cohesiveness of the gels. Larger increases were observed with the addition of 10% of glycol propylene and glycerol contents for methylcellulose and of 20% of carboxymethylcellulose.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 201-206
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Structural research of thermosensitive chitosan-collagen gels containing alp
    Autorzy:
    Skwarczyńska, Agata
    Biniaś, Dorota
    Modrzejewska, Zofia
    Powiązania:
    https://bibliotekanauki.pl/articles/1034675.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    alkaline phosphatase
    chitosan
    collagen
    thermosensitive hydrogels
    Opis:
    Introducing collagen, which is basic ingredient of bone tissue, into the structure of chitosan gels which are formed at the physiological body temperature, is aimed at creating the so-called biomimetic structures, i.e. close in their composition to the natural composition of bone tissue. Within the research the influence of collagen on structural properties of thermosensitive chitosan gels and the influence of ALP on structural properties of chitosan and chitosan-collagen gels was determined.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 176-186
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Application of texture profile analysis to investigate the mechanical properties of thermosensitive injectable chitosan hydrogels
    Autorzy:
    Owczarz, Piotr
    Rył, Anna
    Wichłacz, Żaneta
    Powiązania:
    https://bibliotekanauki.pl/articles/1034254.pdf
    Data publikacji:
    2019
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    TPA
    chitosan
    hydrogels
    injectable scaffolds
    mechanical properties
    Opis:
    In this paper, the mechanical properties of hybrid chitosan hydrogels were investigated using the texture profile analysis test. Scaffolds obtained from a polysaccharide of various molecular weights were studied, which, with the addition of glycerophosphate salt, formed a three-dimensional structure in vivo. The obtained systems were also enriched with collagen and calcium carbonate to improve the mechanical properties. The determined texture parameter values indicate that the mechanical properties of the hybrid hydrogel depend on the molecular weight of the polymer, the type of solvent and, the pH-neutralizing substance, as well as the type and concentration of the filler. Moreover, in some cases the TPA test was the only way to evaluate the mechanical properties of the obtained hydrogels due to the inability to determine the Young's modulus. Consequently, the texture analysis test is a valuable tool for selecting solutions depending on the intended application of the scaffolds.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2019, 24; 151-163
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of the addition of collagen on the rheological properties of chitosan chloride solutions
    Autorzy:
    Owczarz, Piotr
    Rył, Anna
    Modrzejewska, Zofia
    Dziubiński, Marek
    Powiązania:
    https://bibliotekanauki.pl/articles/1034555.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    collagen
    rheology
    thermosensitive hydrogels
    viscoelastic behaviour
    Opis:
    Colloidal solutions of chitosan of crab origin with the addition of collagen obtained from cowhide were studied. Were presents the influence of collagen concentration and the method of preparing the sample on the obtained mechanical properties of the solutions and the observed phase transition temperature. Rheological measurements were performed to determine the viscoelastic properties and phase transition temperatures of these solutions. The study was conducted in the temperature range of 5–60°C with the use of classical techniques of rotational rheometry in the cone-plate measurement system. A significant influence of a collagen addition to chitosan chloride solutions on the viscoelastic properties of the systems was observed. The addition of collagen in all the cases increased the sol–gel phase transition temperature in comparison with the chitosan chloride solution containing β-glycerophosphate.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 176-189
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mechanism of water diffusion into noncrosslinked and ionically crosslinked chitosan membranes
    Autorzy:
    Gierszewska-Drużyńska, Magdalena
    Ostrowska-Czubenko, Jadwiga
    Powiązania:
    https://bibliotekanauki.pl/articles/1035376.pdf
    Data publikacji:
    2012
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    alginate
    chitosan
    pH-responsive hydrogels
    swelling
    tripolyphosphate
    Opis:
    Ionically crosslinked chitosan membranes were prepared and their swelling behaviour was analysed. Low‑molecular pentasodium tripolyphosphate (TPP) and/or high‑molecular sodium alginate (NaAlg) were used as ionic crosslinkers. Dynamic swelling of noncrosslinked (Ch) as well as singly (Ch/TPP, Ch/NaAlg) and doubly (Ch/NaAlg/TPP) crosslinked chitosan membranes was performed in buffered aqueous solutions of various pH to determine the mechanism of water diffusion into these hydrogels. It was stated out that mechanism of water diffusion into studied chitosan hydrogel membranes depends both on pH of swelling solution as well as on the type of membrane (type of crosslinker). The water transport mechanism was determined to be: i) Fickian or ‘Less Fickian’ diffusion, ii) non‑Fickian diffusion (anomalous diffusion) and iii) Case II or Super Case II diffusion.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 63-70
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The formation of hydrogels based on chitosan and its water-soluble derivatives
    Autorzy:
    Il’ina, Alla V.
    Shagdarova, Balzhima Ts.
    Lunkov, Alexey P.
    Varlamov, Valery P.
    Powiązania:
    https://bibliotekanauki.pl/articles/1034059.pdf
    Data publikacji:
    2020
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    crosslinking agent
    gelation
    hydrogels
    quaternized chitosan
    succinyl chitosan
    Opis:
    This review considers articles on the formation of hydrogels based on chitosan as well as succinylated and quaternized chitosan derivatives. They are synthesized using low toxicity reagents, under ordinary conditions (low production costs). Chitosan derivatives are soluble in an extended range of pH values and characterized by mucoadhesiveness, bioavailability and biodegradability, which extends the potential of their medical applications. One of the most important properties of chitosan and its derivatives is the ability to form hydrogels. Depending on the nature of the bonds that occur during formation, hydrogels are divided into chemically or physically crosslinked, or a mixture of the two. Chemically crosslinked gels have covalent bonds, while physically crosslinked gels are formed by noncovalent interactions, for example, ionic. Mixed hydrogels have both types of crosslinking.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 5-15
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of substrate composition on the physicochemical properties of hydrogels with chitosan
    Autorzy:
    Szcześniak, Maria
    Grimling, Bożena
    Meler, Jan
    Pluta, Janusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1034687.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    Carbopl 934P
    PVP
    chitosane
    hydrogels
    pharmaceutical availability
    rheological parameters
    Opis:
    The aim of the study was to evaluate the effect of Carbopol 934 P and PVP K 90 on the rheological properties of chitosan gels. Hydrogels were prepared with hydrocortisone containing chitosan, Carbopl 934P, PVP, propylene glycol-1,2 or polyethyleneglycol 400 and glycerol. Addition of polymers had positive influence on the dispersion of hydrogels. The studied gels have thixotropic properties, their viscosity increases with the increase of the concentration of polymers. Increase of the content of polyvinylpyrrolidone K 90 and Carbopol 934 P increases the consistence, gels are more firm and cohesive. Gels with 5 % chitosane, 15% polyvinylpyrrolidone K 90 and Carbopol 934 P in the presence of additives have prolonged half release period of hydrocortisone.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 187-191
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Structural and biological characteristics of self-organising chitosan hydrogels
    Autorzy:
    Pieklarz, Katarzyna
    Tylman, Michał
    Modrzejewska, Zofia
    Galita, Grzegorz
    Majsterek, Ireneusz
    Powiązania:
    https://bibliotekanauki.pl/articles/2131528.pdf
    Data publikacji:
    2021
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    biomaterials
    chitosan
    cytotoxicity
    self-organising hydrogels
    structural properties
    tissue engineering
    Opis:
    Creating innovative methods of treatment and regeneration of damaged tissues or organs is a key challenge of the twenty-first century. The aim of this study was to determine the possibility of producing and characterising the properties of self-organising chitosan hydrogels prepared with the use of chitosan lactate/chloride and disodium hydrogen phosphate dodecahydrate as a cross-linking agent. The structure and supramolecular architecture of the biomaterials were evaluated by Fourier-transform infrared spectroscopy and polarised optical microscopy. Biological studies assessed cytotoxicity by contact with a human colon adenocarcinoma cell line. The colourimetric resazurin assay showed that the obtained chitosan hydrogels are non-cytotoxic materials. Thus, self-organising biomaterials hold great promise for application in tissue engineering.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2021, 26; 191-199
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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