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Wyświetlanie 1-15 z 26
Tytuł:
Regulation of β1 integrin expression in endothelial cells by chimeric tRNAVal ribozyme
Autorzy:
Papiewska-Pająk, Izabela
Antoszczyk, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/1041244.pdf
Data publikacji:
2006
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
integrins
cell migration
β1 integrin subunit
hammerhead ribozyme
Opis:
To downregulate expression of the β1 integrin subunit in endothelial cells, plasmid encoding the ribozyme cassette containing hammerhead ribozyme flanked at the 5' terminus by tRNAVal and at the 3' terminus by constitutive transport element sequences was constructed. When used to transfect immortalized human endothelial cell line EA.hy 926, it selectively blocked the synthesis of the β1 integrin subunit and thus inhibited migration and proliferation of the cells. Thus, this construct may be a valuable tool to control the proangiogenic phenotype of stimulated endothelial cells.
Źródło:
Acta Biochimica Polonica; 2006, 53, 2; 311-316
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Partial deglycosylation of α subunit modifies sturgeon gonadotropin function.
Autorzy:
Zenkeviès, Henriks
Vose, Vija
Vosekalne, Ilze
Bcena, Ausma
Powiązania:
https://bibliotekanauki.pl/articles/1044331.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
α subunit
CD spectrum
sturgeon GTH
gonadotropic hormone
deglycosylation
Opis:
Chemical deglycosylation (dg) of sturgeon Acipenser gueldenstaedti Br. (αGTH) resulted in the loss of 83% of its initial carbohydrate content. It altered also recombinant dgαGTH + βGTH dimer molecule, reducing its immunoreactivity by 30%, and fully blocking the hormonal function. CD spectroscopy showed that deglycosylation led to changes in the secondary structure of dgαGTH and in the α-β recombinant. The sugar moiety of sturgeon αGTH is suggested to play an important role in maintaining the biological function of the hormone dimer molecule.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 815-819
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Additional copies of the NOG2 and IST2 genes suppress the deficiency of cohesin Irr1p/Scc3p in Saccharomyces cerevisiae.
Autorzy:
Białkowska, Agnieszka
Kurlandzka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1043770.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
60S ribosomal subunit
sister chromatid cohesion
salt tolerance
Opis:
The protein encoded by the IRR1/SCC3 gene is an element of the cohesin complex of Saccharomyces cerevisiae, responsible for establishing and maintaining sister chromatid cohesion during mitotic cell division. We noticed previously that lowering the level of expression of IRR1/SCC3 affects colony formation on solid support. Here we describe two dosage suppressors (IST2, NOG2) overcoming the inability to form colonies of an Irr1p-deficient strain. Ist2 is probably involved in osmotolerance, Nog2p is a putative GTPase required for 60S ribosomal subunit maturation, but may also participate in mRNA splicing.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 421-425
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ultrastructure and SSU rDNA Phylogeny of Paraphysomonas vestita (Stokes) De Saedeleer Isolated from Laguna de Bay, Philippines
Autorzy:
Petronio, Joy Ann G.
Rivera, Windell L.
Powiązania:
https://bibliotekanauki.pl/articles/763493.pdf
Data publikacji:
2010
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:
Paraphysomonas vestita, chrysophyte, protist, ultrastructure, small subunit ribosomal RNA gene, Philippines
Opis:
Paraphysomonas vestita is a unicellular, colorless, silica-scaled chrysophyte that plays an important ecological role in freshwater microbial communities as a consumer of prokaryotic and eukaryotic prey. There is little biogeographical information for this minute protist despite its significant role in aquatic food webs. In addition, the phylogenetic relationship of P. vestita to other taxa is unclear as P. vestita may be polyphyletic or a cryptic species complex. In this study, a clonal isolate from a freshwater sample of Laguna de Bay, Philippines was subjected to morphological study by electron microscopy and its small subunit ribosomal RNA (SSU rRNA) gene was sequenced. Morphological studies showed that the isolate possesses two unequal flagella emerging from the anterior part of the cell. Negative staining revealed the structure of the scales which consist of a baseplate with slightly thickened rim. The narrowing spine arises from the center of the baseplate. These results agree with previously studied isolates of P. vestita. The 18S rRNA gene sequence of the isolate had a very high similarity (99%) to P. vestita strain PV10. Phylogenetic analysis also showed that the isolate clustered with other Paraphysomonas sequences with high bootstrap support. Phylogenetic studies confirmed that P. vestita may be polyphyletic. No studies on the ultrastructure and phylogeny of a silica-scaled chrysophyte isolated in the Philippines have been reported so far. Results from this study may contribute to further ultrastructural and phylogenetic studies on aquatic flagellates and specifically to a revision of this potentially polyphyletic species.
Źródło:
Acta Protozoologica; 2010, 49, 2
1689-0027
Pojawia się w:
Acta Protozoologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Production and characterization of swine hyperimmune serum against recombinant, common antigens of Gram-negative outer membrane bacteria
Autorzy:
Rząsa, A.
Pietrasina, O.
Czerniecki, M.
Bajzert, J.
Stefaniak, T.
Powiązania:
https://bibliotekanauki.pl/articles/2087590.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
swine
recombinant outer membrane proteins
antibody response
hyperimmune serum
subunit vaccine
Źródło:
Polish Journal of Veterinary Sciences; 2019, 1; 117-125
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Isolation and expression pattern of RGS21 gene, a novel RGS member
Autorzy:
Li, Xin
Chen, Lei
Ji, Chaoneng
Liu, Bing
Gu, Jiefeng
Xu, Jian
Zou, Xianqiong
Gu, Shaohua
Mao, Yumin
Powiązania:
https://bibliotekanauki.pl/articles/1041351.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
RGS21
G-protein signaling pathway
G-protein α subunit (Gα)
Opis:
Regulators of G-protein signaling (RGS) proteins are known for the RGS domain that is composed of a conserved stretch of 120 amino acids, which binds directly to activated G-protein α subunits and acts as a GTPase-activating protein (GAP), leading to their deactivation and termination of downstream signals. In this study, a novel human RGS cDNA (RGS21), 1795 bp long and encoding a 152-amino acid polypeptide, was isolated by large-scale sequencing analysis of a human fetal brain cDNA library. Unlike other RGS family members, RGS21 gene has no additional domain/motif and may represent the smallest known member of RGS family. It may belong to the B/R4 subfamily, which suggests that it may serve exclusively as a negative regulator of αi/o family members and/or αq/11. PCR analysis showed that RGS21 mRNA was expressed ubiquitously in the 16 tissues examined, implying general physiological roles.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 943-946
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Policemen of Anti-Terrorist Subunits in Scientific Research
Autorzy:
Zubrzycki, Waldemar
Powiązania:
https://bibliotekanauki.pl/articles/1861556.pdf
Data publikacji:
2016
Wydawca:
Wyższa Szkoła Bezpieczeństwa Publicznego i Indywidualnego Apeiron w Krakowie
Tematy:
The Police
anti-terrorism
fighting terrorism
anti-terrorist subunit
police special commando
Opis:
Service in a special unit of the Police is extremely tedious, both in physical and mental terms, with very high expectations for their policemen. It cannot arise only from official duties, but – above all – specific lifestyle, which should be the primary stimulus for taking them. It is confirmed by research conducted among policemen-antiterrorists, relating to their motivation in taking service in anti-terrorist subunit of the Police. Studies have also shown that such service is not fully in line with the expectations of the officers, and their priorities change over its course. A lot of factors have impact on it, negatively affecting the attitude of policemen, which were revealed in the study. The results can be used to create such conditions of service, which will reduce or eliminate loss of idealistic motives for taking service in the special unit of the Police.
Źródło:
Security Dimensions; 2016, 17(17); 30-41
2353-7000
Pojawia się w:
Security Dimensions
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Calcareous nannofossils and foraminifera from the youngest deposits of the Siary Subunit (Oligocene, Magura Nappe, Polish Outer Carpathians)
Autorzy:
Garecka, M.
Szydło, A.
Powiązania:
https://bibliotekanauki.pl/articles/191190.pdf
Data publikacji:
2015
Wydawca:
Polskie Towarzystwo Geologiczne
Tematy:
calcareous nannoplankton
foraminifera
palaeoenvironment
Gładyszów Beds
Siary Subunit
Magura Nappe
Outer Carpathians
Oligocene
Opis:
The calcareous nannoplankton and foraminifera from the Gładyszów Beds, regarded as the youngest deposits in the northern marginal Siary Subunit of the Magura Nappe in Poland, are characterized. The material investigated comes from outcrops in the vicinity of Gładyszów and from the Gładyszów PIG-1 borehole. The analysis allowed the establishment of the age of these deposits as not older than late Rupelian–early Chattian (the calcareous nannoplankton NP24 Zone). The taxonomic affiliations, environmental associations and preservation of the microfossils were analyzed to document the sedimentary processes and environmental conditions during the geotectonic transformation of the Magura Basin in the Oligocene. These microfossils also were compared with those reported from the terminal deposits of the Outer Carpathians and the Podhale Basin.
Źródło:
Annales Societatis Geologorum Poloniae; 2015, 85, 1; 205-219
0208-9068
Pojawia się w:
Annales Societatis Geologorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Geology of the Magura Nappe in the Osielec area with emphasis on an Eocene olistostrome with metabasite olistoliths (Outer Carpathians, Poland)
Autorzy:
Cieszkowski, M.
Kysiak, T.
Szczęch, M.
Wolska, A.
Powiązania:
https://bibliotekanauki.pl/articles/191808.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Geologiczne
Tematy:
Magura Nappe
Rača Subunit
Late Cretaceous-Palaeogene
lithostratigraphy
tectonics
olisto- strome
olistoliths
metabasite
Opis:
The Magura Nappe in the Polish sector of the Outer Carpathians consists of four tectonic subunits characterized by differing development of facies. From the south to the north, they include the Siary, Rača, Bystrica and Krynica subunits. The sedimentary succession in the Rača Subunit in the vicinity of the village of Osielec is composed of Campanian–Palaeogene flysch deposited in the Magura Basin. In this succession, the Middle Eocene Pasierbiec Sandstone Fm consists of thick-bedded sandstones and conglomerates with occasional intercalations of thin-bedded shale-sandstone flysch. Within the Pasierbiec Sandstone Fm at Osielec there is an olistostrome, rich in pebbles and cobbles of exotic rocks. In addition, large blocks of Neoproterozoic metabasites and boulders of Palaeogene organogenic limestones were found. The discovery of metabasites raised the possibility that the rocks in question could be evidence of supposed oceanic crust in the basement of the Magura sedimentary basin, because of the suggestion that they represent the Alpine orogenic cycle. This concept was abandoned when investigations of the absolute age of the metabasites gave a date of ca. 600 Ma. In the Osielec area, there are two tectonic thrust sheets in the Rača Subunit, namely the Osielczyk Thrust Sheet in the north and the Bystra Thrust Sheet in the south; they are folded and cut by a transverse system of strike-slip and oblique faults. The Osielczyk Thrust Sheet was overthrust northwards on to the Siary Subunit.
Źródło:
Annales Societatis Geologorum Poloniae; 2017, 87, 2; 169-182
0208-9068
Pojawia się w:
Annales Societatis Geologorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structure and functions of 5S rRNA.
Autorzy:
Barciszewska, Mirosława
Szymański, Maciej
Erdmann, Volker
Barciszewski, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1044186.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
50S subunit structure
ribosomal 5S RNA
5S rRNA
crystal structure
Opis:
The ribosome is a macromolecular assembly that is responsible for protein biosynthesis in all organisms. It is composed of two-subunit, ribonucleoprotein particles that translate the genetic material into an encoded polypeptides. The small subunit is the site of codon-anticodon interaction between the messenger RNA (mRNA) and transfer RNA (tRNA) substrates, and the large subunit catalyses peptide bond formation. The peptidyltransferase activity is fulfilled by 23S rRNA, which means that ribosome is a ribozyme. 5S rRNA is a conserved component of the large ribosomal subunit that is thought to enhance protein synthesis by stabilizing ribosome structure. This paper shortly summarises new results obtained on the structure and function of 5S rRNA.
Źródło:
Acta Biochimica Polonica; 2001, 48, 1; 191-198
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Morphology and Molecular Phylogeny of Pseudouroleptus jejuensis nov. spec., a New Soil Ciliate (Ciliophora, Spirotrichea) from South Korea
Autorzy:
JUNG, Jae-Ho
Park, Kyung-Min
Min, Gi-Sik
Powiązania:
https://bibliotekanauki.pl/articles/763471.pdf
Data publikacji:
2014
Wydawca:
Uniwersytet Jagielloński. Wydawnictwo Uniwersytetu Jagiellońskiego
Tematy:
Pseudouroleptus jejuensis, soil ciliate, morphology, small subunit ribosomal RNA gene, oxytrichid, South Korea
Opis:
A new soil ciliate, Pseudouroleptus jejuensis, was discovered from Jeju Island, South Korea and described based on live observation, protargol impregnation, and SSU rRNA gene sequence analyses. Pseudouroleptus jejuensis differs from other congeneric species mainly by number of dorsal kineties (5 vs. 4). Based on our observation of late dividers, we confirm that the dorsal kinety anlage 3 forms 3 kineties (i.e., dorsal kineties 3–5), and the dorsal kinety anlagen 1–3 form 3–5/1–2/0 caudal cirri, respectively. Our gene trees support the assignment of this new species in Pseudouroleptus to full supporting values.
Źródło:
Acta Protozoologica; 2014, 53, 2
1689-0027
Pojawia się w:
Acta Protozoologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The uselessness of cytochrome oxydase gene analysis for genetic identification of selected Gobiidae species from some European countries
Autorzy:
Kiełpińska, Jolanta
Czerniejewski, Przemysław
Adamkowska, Natalia
Uzunova, Eliza
Powiązania:
https://bibliotekanauki.pl/articles/2203561.pdf
Data publikacji:
2022
Wydawca:
Instytut Technologiczno-Przyrodniczy
Tematy:
cytochrome oxidase subunit 1 gene
COI gene
Gobiidae
invasive species
native species
mt DNA
Opis:
The family Gobiidae is the largest teleost family, consisting of more than 2,000 species in more than 200 genera. They have adapted to a wide range of habitats, inhabiting mostly marine and brackish waters. Recently invasive Ponto-Caspian gobies have caused significant changes to the structure of fish assemblage throughout the European waters. The aim of the study was to verify the possibility of identifying three species of the genus Gobiidae based on the analysis of the mitochondrial region of the cytochrome oxidase subunit 1 (COI) gene. 339 samples originated from seven countries and 17 different sites were investigated. Qualitative and quantitative assessment of the extracted DNA was conducted by measuring light absorbance and electrophoretic separation. Approximately 650-bp (base pairs) fragments were amplified from the 5' region of the mitochondrial COI with the PCR (polymerase chain reaction) reaction. Sequences of 652 bp were obtained and compared with reference sequences in the National Center for Biotechnology Information (NCBI). Based on the sequence analysis, we determined that in the analysed geographical regions, the goby preliminary identified morphologically as the round goby was represented by three species: round goby (Neogobius melanostomus), tubenose goby (Proterorhinus marmoratus), and monkey goby (Neogobius fluviatilis). The latter two are newly reported for their new habitats. Genetic characterisation of such populations offers the opportunity to assess their genetic stability, which provides agencies managing the aquatic environment in EU countries with a tool for revising the legislation, including regulations relevant for updating the status of native and invasive species in European waters.
Źródło:
Journal of Water and Land Development; 2022, Special Issue; 8--14
1429-7426
2083-4535
Pojawia się w:
Journal of Water and Land Development
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza virus hemagglutinin as a vaccine antigen produced in bacteria
Autorzy:
Sączyńska, Violetta
Powiązania:
https://bibliotekanauki.pl/articles/1039263.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
recombinant influenza hemagglutinin
recombinant influenza vaccine
subunit influenza vaccine
bacterial hemagglutinin
prokaryotic protein production
Opis:
Recombinant subunit vaccines based on hemagglutinin proteins produced in bacteria (bacterial HAs) are promising candidates for enhancing the supply of vaccines against influenza, especially for a pandemic. Over 20 years after the failure to obtain the antigen with native HA characteristics in the early 1980’s, there are increasing data on successful production of HA proteins in bacteria. The vast majority of bacterial HAs have been based on the HA1 subunit of HA expressed separately or as a component of conjugate vaccines, but those based on the ectodomain and the HA2 subunit have also been reported. The most of HAs have been efficiently expressed as insoluble aggregates called inclusion bodies. Refolded and purified proteins were extensively studied for structure, the ability to bind to sialic acid-containing receptors, antigenicity, immunogenicity and efficacy. The results from these studies contradict the view that glycosylation determines the correct structure of the hemagglutinin, as they proved that bacterial HAs can be valuable vaccine antigens when appropriate folding and purification methods are applied to rationally designed proteins. The best evidence for success in bacterial production of protective HA is that vaccines based on proprietary Toll-like Receptor (VaxInnate) and bacteriophage Qβ-VLPs (Cytos Biotechnology) technologies have been advanced to clinical studies.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 561-572
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cyclic AMP deficiency stimulates a stress condition in tobacco BY-2 cells
Autorzy:
Sgobba, A.
Sabetta, W.
Blanco, E.
Paradiso, A.
Viggiano, L.
De Pinto, M.
Powiązania:
https://bibliotekanauki.pl/articles/80076.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
cyclic amphipathic peptide
stress condition
tobacco
BY-2 cell
cell cycle progression
plant
subunit
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immune signalling and vesicular trafficking – intertwining networks regulated by E3 ubiquitin ligases
Autorzy:
Stegmann, M.
Furlan, G.
Anderson, R.G.
Ichimura, K.
McDowell, J.M.
Shirasu, K.
Trujillo, M.
Powiązania:
https://bibliotekanauki.pl/articles/80842.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
pattern recognition receptor
pathogen-associated molecular pattern
ubiquitin ligase
subunit
exocytosis
immune response
vesicular trafficking
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
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