- Tytuł:
-
Reakcja Mitsunobu : mechanizm i zastosowanie
Mitsunobu reaction : mechanism and application - Autorzy:
-
Kitkowska, J. D.
Tabaczyńska, Ż. A.
Dramiński, M. - Powiązania:
- https://bibliotekanauki.pl/articles/171670.pdf
- Data publikacji:
- 2013
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
reakcja Mitsunobu
kondensacja
inwersja konfiguracji
stereoselektywność
Mitsunobu reaction
condensation
configuration inversion
stereoselectivity - Opis:
- The Mitsunobu reaction has been known since 1967, but the research on its modifications as well as on the introduction of new reagents, productivity, improvement and methods of post-reaction mixture separation is still being conducted. The original reaction was used to obtain esters by condensation of carboxylic acids and alcohols using triphenylphosphine and DEAD mixture. This reaction allows formation of s not only carbon-oxygen bond, but also carbon-carbon, carbon-nitrogen, and carbon-sulphur to be synthesized. The Mitsunobu reaction is widely applied in organic synthesis as a way of inversion of configuration of secondary alcohols or of aryl ethers synthesis. Numerous studies bring the accounts of using this reaction for the synthesis of steroids, carbohydrates, nucleosides, as well as alkaloids and other heterocyclic compounds containing nitrogen. The popularity of this reaction lies in its stereoselectivity and compatibility with a wide range of functional groups as well as in its moderate requirements considering reaction conditions. However, an isolation of a desirable product from the used up or surplus reagents still causes a lot of difficulties.
- Źródło:
-
Wiadomości Chemiczne; 2013, 67, 9-10; 843-876
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł