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Tytuł:
Cell therapy for regenerative medicine: facts and controversy
Fakty i kontrowersje związane z terapią komórkową w medycynie regeneracyjnej
Autorzy:
Sarnowska, Anna
Machaliński, Bogusław
Radoszkiewicz, Klaudia
Bużańska, Leonora
Powiązania:
https://bibliotekanauki.pl/articles/2121315.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
cell therapy
regenerative medicine
human mesenchymal stem cells
human induced pluripotent stem cells
Opis:
Cellular therapy, as a part of regenerative medicine, implies to the treatment of human disorders with cells as a medical product, so called – “living drugs”. Usually such therapy is applied when other alternative efficient pharmacological therapies are not available. Stem cells of different origin: 1) tissue specific e.g. hematopethic, epithelial, neuronal, limbal; 2) mesenchymal stem cells (MSC) harvested from variety of tissues; 3) pluripotent stem cells: embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) – serve as a source of cells for regenerative medicine application, depending upon disease and application re- quirements. Currently MSC are the type of stem cells that are most frequently used in registered regenerative medicine clinical trials. In this paper we provide the information on the application of cell therapy in orthopedics, hematology, ophthalmology, dermatology, gastrology and neurology. The influence of origin of MSCs and iPSCs on their mode of action as therapeutic, regenerative agents are discussed. Advantages and disadvantages of application of different cell types for cell therapy are underlined. Last, but not least current low regulations in Poland and requirements of European regulatory bodies for cell therapy are pointed out and discussed.
Źródło:
Nauka; 2021, 4; 67-92
1231-8515
Pojawia się w:
Nauka
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hydrolyzed Collagen from Salmon Skin Increases the Migration and Filopodia Formation of Skin Keratinocytes by Activation of FAK/Src Pathway
Autorzy:
Woonnoi, Wanwipha
Chotphruethipong, Lalita
Tanasawet, Supita
Benjakul, Soottawat
Sutthiwong, Nuthathai
Sukketsiri, Wanida
Powiązania:
https://bibliotekanauki.pl/articles/1417272.pdf
Data publikacji:
2021-09-03
Wydawca:
Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
Tematy:
cell culture
keratinocyte stem cells
marine collagen
re-epithelialization
skin barrier
wound healin
Opis:
Previous studies reported hydrolyzed collagen increase cell proliferation and migration involved in the wound repair process. Nevertheless, the knowledge related with wound repair mechanism of hydrolyzed collagen from salmon skin (HCSS) has not been fully elucidated. Therefore, this study aimed to elucidate the effects of HCSS on the migration of keratinocyte HaCaT cells. Additionally, its molecular mechanism through cell division control protein 42 (Cdc42), Ras-related C3 botulinum toxin substrate 1 (Rac1), and Ras homolog family member A (RhoA) via focal adhesion kinase (FAK)-steroid receptor coactivator (Src) regulation and keratinocyte stem cells (KSCs) markers were also evaluated. After 24 h of incubation, keratinocyte proliferation was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and double stranded DNA (dsDNA) assays, and by determining the total cellular protein content. Keratinocyte migration and filopodia formation were measured by wound healing assay and phalloidin‐rhodamine staining, respectively. The migratory related proteins were evaluated by western blot analysis. HCSS had a high content of hydrophobic amino acids and imino acids. HaCaT cell proliferation and migration were significantly increased in response to HCSS at the concentration of 100-1000 μg/mL. The formation of filopodia was subsequently increased in response to HCSS at concentrations of 100-1000 μg/mL. Moreover, HCSS upregulated Cdc42, Rac1, and RhoA protein expression and activated the phosphorylation of FAK and Src pathway. HCSS at the concentration of 100-1000 μg/mL could trigger stemness by increased KSC markers, including keratin 19 and β-catenin expression. This study has demonstrated that HCSS induces proliferation and migration of keratinocytes, subsequently promotes the second phase of wound healing process by FAK-Src activation and also increases the KSC properties.
Źródło:
Polish Journal of Food and Nutrition Sciences; 2021, 71, 3; 323-332
1230-0322
2083-6007
Pojawia się w:
Polish Journal of Food and Nutrition Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Myeloablative chemotherapy in testicular cancer patient
Autorzy:
Furgała, Karolina
Smuniewska, Zuzanna
Sigorski, Dawid
Michalak, Maciej
Bodnar, Lubomir
Powiązania:
https://bibliotekanauki.pl/articles/2047202.pdf
Data publikacji:
2021-03-24
Wydawca:
Medical Education
Tematy:
chemotherapy
autologous hematopoietic stem cell transplantation
non-seminoma
Opis:
Chemotherapy is the standard treatment for metastatic testicular cancers. The autologous hematopoietic stem cell transplantation is a salvage option for relapsed patients. The paper presents a case of a 20-year-old patient with stage IIIC non-seminoma treated with BEP chemotherapy and autologous transplantation of stem cells, which allowed to achieve durable remission.
Źródło:
OncoReview; 2021, 11, 1; 19-21
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Potential therapeutic application of mesenchymal stem cells in COVID-19 complications
Autorzy:
Kolanko, Emanuel
Mazurski, Adam
Czekaj, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/2108204.pdf
Data publikacji:
2021-12-22
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational diseases
mesenchymal stem cells
cell therapy
complementary therapy
COVID-19
SARS-CoV-2 mutations
Opis:
Mesenchymal stem cells (MSCs) have remarkable immunomodulatory properties, low immunogenicity, and paracrine properties as well as the ability to differentiate into multiple cell lines. These properties make them potential candidates for clinical applications in the treatment of neurodegenerative, cardiovascular, and lung diseases, which may be occupational diseases. Preclinical studies using experimental animal models have demonstrated regenerative properties of MSCs in diseases such as silicosis and occupational asthma. Currently, treatment of the novel disease COVID-19 could be enhanced by using MSC therapies. This disease affects many professional groups with great intensity and its consequences might be considered as an occupational disease. It is a significant public health problem and a therapeutic challenge. Despite the development of vaccines against COVID-19, there is growing concern about the emergence of new mutations of the SARS-CoV-2 virus in addition to the known alpha, beta, gamma, and delta variants. There is still no effective COVID-19 treatment and the existing ones only play a supporting role. MSCs offer treatment possibilities as an alternative or complementary therapy. The clinical trials to date using MSCs in patients with COVID-19 give hope for the safe and effective use of this stem cell population.
Źródło:
Medycyna Pracy; 2021, 72, 6; 693-700
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Terapia komórkowa w schorzeniach zwyrodnieniowych siatkówki – nadzieje i zagrożenia
Cell therapy in degenerative retinal diseases: expectations and threats
Autorzy:
Machalińska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1034206.pdf
Data publikacji:
2020
Wydawca:
Medical Education
Tematy:
komórki macierzyste
terapia komórkowa
zwyrodnienie barwnikowe siatkówki
cell therapy
stem cells
retinitis pigmentosa
Opis:
Currently, for many retinal degenerative diseases there is no effective treatment based on disease etiology. Neurotrophic factors secreted by the applied cells are responsible for improved morphology and function of degenerative retina. Moreover, these cells present immunomodulatory effect and reduce the inflammatory response of the damaged tissue. The best effect is obtained at the initial stage of the disease. Despite promising preliminary results, cell therapy requires further investigation to evaluate its efficacy and long-term safety. It is worth to underline that cell therapy should be conducted only as part of free clinical trials in certified research centers after obtaining the patient's informed consent for treatment
Obecnie brakuje skutecznego leczenia przyczynowego wielu chorób degeneracyjnych siatkówki. Za poprawę morfologii i funkcji degenerującej siatkówki odpowiadają czynniki neurotroficzne wydzielane przez aplikowane komórki, które wykazują dodatkowo wpływ immunomodulujący i redukują odpowiedź zapalną uszkodzonej tkanki. Najlepsze efekty uzyskuje się w początkowym stadium zaawansowania choroby. Pomimo obiecujących wstępnych wyników terapia komórkowa wymaga dalszych badań oceniających jej skuteczność i długoterminowe bezpieczeństwo. Ponadto powinna być prowadzona tylko w ramach bezpłatnych badań klinicznych w certyfikowanych ośrodkach naukowo-badawczych po uzyskaniu świadomej zgody pacjenta na leczenie.
Źródło:
OphthaTherapy; 2020, 7, 1; 30-35
2353-7175
2543-9987
Pojawia się w:
OphthaTherapy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ANALYSIS OF CHRONIC MYELOID LEUKEMIA PHARMACOTHERAPY COSTS IN POLAND
Autorzy:
Paczkowska, Anna
Kus, Krzysztof
Nowicka, Monika
Kopciuch, Dorota
Zaprutko, Tomasz
Komarnicki, Mieczysław
Nowakowska, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/895298.pdf
Data publikacji:
2019-02-28
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
poland
chronic myeloid leukemia
stem cell transplantation
pharmacotherapy cost analysis
Opis:
The aim of this study was to analyze pharmacotherapy cost of chronic myeloid leukemia from the society’s, the payer’s (National Health Fund), and the patient’s perspective. The study included 55 patients with a diagnosed and treated chronic myeloid leukemia at the selected hematology clinic in the city of Poznan. Retrospective study involved time horizon of one calendar year – 2013. The data required for economic evaluation were obtained from the patients’ case histories and the Department of Organization and Accounting of the selected health care facilities. The total cost of chronic myeloid leukemia pharmacotherapy for 55 patients from the society’s perspective in 2013 amounted to 1,483,416.88 EUR. Average annual cost of medication per patient in 2013 amounted to 26,971.22 EUR (Median – 32,854.22 EUR). Average cost of chronic myeloid leukemia pharmacotherapy for a patient without transplantation was 32,167.34 EUR (Median – 30,623.00 EUR), and for a patient after transplantation amounted to 413.13 EUR (Median – 378.40 EUR). The cost from the payer’s perspective is 99.93% of total costs from the society’s perspective. The cost from the patient’s perspective represents 0.07% of the total cost of chronic myeloid leukemia pharmacotherapy from the society’s perspective. Costs of chronic myeloid leukemia pharmacotherapy are very high and represent a significant burden to society. The highest costs associated with treatment of chronic myeloid leukemia are incurred by the society, and, subsequently, the public payer (NHF), and the patient.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 1; 175-183
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Czy terapia komórkami macierzystymi to przyszłość w leczeniu pacjentów z Mózgowym Porażeniem Dziecięcym?
Is stem cell therapy a future for the treatment of patients with Cerebral Palsy?
Autorzy:
Krukowska-Andrzejczyk, Barbara
Cebula, Agnieszka
Głuszkiewicz, Ewa
Kopyta, Ilona
Powiązania:
https://bibliotekanauki.pl/articles/1819304.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Neurologów Dziecięcych
Tematy:
mózgowe porażenie dziecięce
choroby układu nerwowego
dziecko
komórki macierzyste
terapia komórkowa
cerebral palsy
nervous system disease
child
stem cell
cell based therapy
Opis:
Mózgowe porażenie dziecięce (MPD) jest jedną z najczęstszych przyczyn niepełnosprawności wśród dzieci, a terapia MPD jest jednym z głównych wyzwań neurologii dziecięcej. Pomimo dowodów na skuteczność rehabilitacji i interwencji chirurgicznych na poprawę funkcjonowania pacjentów z MPD, brak jest obecnie skutecznego leczenia, które zmniejszałoby nasilenie choroby i wpływało na trwałą poprawę funkcjonowania pacjentów. Jednym z priorytetowych tematów badawczych jest obecnie zastosowanie komórek macierzystych w terapii chorób neurologicznych, w tym w MPD. W ostatnich kilku latach wzrasta liczba dokonanych podań komórek macierzystych u pacjentów z MPD, jak również prowadzonych badań klinicznych. Niniejszy artykuł przedstawia aktualny stan wiedzy dotyczący terapii MPD komórkami macierzystymi w celu odpowiedzi na pytanie czy terapia komórkami macierzystymi to szansa na bardziej efektywne leczenie pacjentów z MPD.
Cerebral palsy (CP) is one of the most common causes of disability among children and CP therapy is one of the main challenges in pediatric neurology. Despite evidence of the effectiveness of rehabilitation and surgical interventions to improve the functioning of patients with CP, there is no effective treatment that would reduce the severity of the disease and affect the permanent improvement of functioning. One of the leading topics of current research is the use of stem cells in the treatment of neurological diseases, including CP. In the last few years the number of stem cell applications in CP as well as clinical trials has been increasing. This article presents the current state of knowledge regarding stem cell therapy in order to answer the question whether stem cell therapy is an opportunity for more effective treatment of patients with CP.
Źródło:
Neurologia Dziecięca; 2019, 28, 56; 27-38
1230-3690
2451-1897
Pojawia się w:
Neurologia Dziecięca
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative analysis of cat bone marrow and adipose tissue cell cultures
Autorzy:
Mazurkevych, A.
Malyuk, M.
Kovpak, V.
Kovpak, O.
Kharkevych, Y.
Jakubczak, A.
Gryzinska, M.
Powiązania:
https://bibliotekanauki.pl/articles/2087658.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
stem cells
bone marrow cell culture
adipose tissue cell culture
cytogenetic assays
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 3; 549-557
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of Insulin and Embryonic Stem Cells loaded PLGA Nanoparticles on Pancreatic Beta TC Cells
Autorzy:
Yücel, Çiğdem
Aktaş, Yeşim
Değim, Zelihagül
Yılmaz, Şükran
Arsoy, Taibe
Altıntaş, Levent
Çokçalışkan, Can
Sözmen, Mahmut
Powiązania:
https://bibliotekanauki.pl/articles/895523.pdf
Data publikacji:
2018-12-31
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
diabetes
insulin
embryonic stem cell
PLGA nanoparticles
pancreatic beta TC cell
Opis:
In The present study, the aims was to investigate and compare the effect of insulin and embryonic stem cells (ESC) loaded nanoparticle formulations (NPs) on pancreatic-beta-TC-cell regeneration. Characterization studies of NPs were performed. Permeability of insulin and the effect of ESC on pancreatic beta cells were investigated. by the determination of Insulin or glucose levels were determined and histologic investigations were also performed. ESC encapsulation efficiency was calculated by western blot analysis. The particle sizes of insulin and ESC-loaded-NPs were determined as 0.665±0.202 µm and 0.650 ±0.310 µm. The mean zeta potentials of insulin and ESC-loaded-NPs nanoparticles were found as 6.88±0.729 mV, 5.13±0.631 mV. The polydispersity index of insulin and ESC nanoparticles were 0.660±0.175, 0.620±0.205 respectively. Encapsulation efficiency of insulin and ESC-loaded-NPs were found to be 50±1.53% and 51%. Insulin release from nanoparticles was found to be 72.8% over 48h. The gGlucose concentrations wasere decreased to 201 and 202.7 mg/dl from 250 mg/dl in streptozocin (STZ) induced diabetic mice group after insulin and ESC-loaded-NPs administration. Insulin and ESC-loaded-NPs improved the blood insulin levels in all experimental groups. These NPs may be used for repairing of pancreatic cells. Healing or some degree of regeneration was observed when insulin and ESC-loaded-NPs were administered to the mice ip. ESC-loaded-NPs can be a potential source for cell replacement therapy in the treatment of diabetes.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 6; 1377-1389
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Optimization of differentiation time of mesenchymal-stem-cell to tenocyte under a cyclic stretching with a microgrooved culture membrane and selected measurement cells
Autorzy:
Morita, Y.
Yamashita, T.
Toku, Y.
Yu, Y.
Powiązania:
https://bibliotekanauki.pl/articles/307018.pdf
Data publikacji:
2018
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
różnicowanie
kości
stymulacja mechaniczna
hBMSC
cyclic stretch
differentiation
differentiation time
human bone marrow-derived mesenchymal stem cell
mechanical stimulus
tenocyte
Opis:
There is a need for efficient stem cell-to-tenocyte differentiation techniques for tendon tissue engineering. More than 1 week is required for tenogenic differentiation with chemical stimuli, including co-culturing. Research has begun to examine the utility of mechanical stimuli, which reduces the differentiation time to several days. However, the precise length of time required to differentiate human bone marrow-derived mesenchymal stem cells (hBMSCs) into tenocytes has not been clarified. Understanding the precise time required is important for future tissue engineering projects. Therefore, in this study, a method was developed to more precisely determine the length of time required to differentiate hBMSCs into tenocytes with cyclic stretching stimulus. Methods: First, it had to be determined how stretching stimulation affected the cells. Microgrooved culture membranes were used to suppress cell orientation behavior. Then, only cells oriented parallel to the microgrooves were selected and evaluated for protein synthesis levels for differentiation. Results: The results revealed that growing cells on the microgrooved membrane and selecting optimally-oriented cells for measurement improved the accuracy of the differentiation evaluation, and that hBMSCs differentiated into tenocytes in approximately 10 h. Conclusions: The differentiation time corresponded to the time required for cellular cytoskeleton reorganization and cellular morphology alterations. This suggests that cells, when subjected to mechanical stimulus, secrete mRNAs and proteins for both cytoskeleton reorganization and differentiation.
Źródło:
Acta of Bioengineering and Biomechanics; 2018, 20, 1; 3-10
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cell therapy in surgical treatment of fistulas. Preliminary results
Autorzy:
Piejko, Marcin
Romaniszyn, Michał
Borowczyk-Michałowska, Julia
Drukała, Justyna
Wałęga, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1393600.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
anal fistula
stem cell-based therapy
recurrent fistula
regenerative medicine
rectovaginal fistula
Opis:
Risk of recurrence after surgical treatment of a recurrent fistula is up to 50%. It has be known that more aggressive surgical treatment is associated with a high risk of anal sphincter damage and leads to incontinence. Several studies have been designed to elaborate minimally invasive treatment of rectovaginal and anal fistulas. The properties of Adipose-derived Stem Cells (ASC) significantly enhance a natural healing potency. Here, we present our experience with combined surgical and cell therapy in the treatment of fistulas. Materials and Methods: Four patients were enrolled in our study after unsuccessful treatments in the past – patients 1-3 with rectovaginal fistulas including two women after graciloplasty, and patient 4 - a male with complex perianal fistula. Adipose tissue was obtained from subcutaneous tissue. ASCs were isolated, cultured up to 10+/-2 mln cells and injected into the walls of fistulas. Follow-up physical examination and anoscopy were performed at 1, 4, 8, and 12 weeks, 6 and 12 months after implantation. Results: Up to 8 weeks after ASC implantation, symptoms of fistulas’ tracts disappeared. At 8 weeks, in patients 1-3, communication between vaginal and rectal openings was closed and at 12-16 w. intestinal continuity was restored in patient 3 and 4. After a 6-month follow-up, the fistula tract of patient 4 was closed. Up to 12 m. after ASC implantation no recurrences or adverse events were observed. Conclusion: ASCs combined with surgical pre-treated fistula tracts were used in four patients. All of them were healed. This encouraging result needs further trials to evaluate the clinical efficiency and the cost-effectiveness ratio.
Źródło:
Polish Journal of Surgery; 2017, 89, 3; 48-51
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cerebral toxoplasmosis after haematopoietic stem cell transplantation
Autorzy:
Zaucha-Prażmo, Agnieszka
Samardakiewicz, Marzena
Dubelt, Joanna
Kowalczyk, Jerzy R.
Powiązania:
https://bibliotekanauki.pl/articles/989773.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
toxoplasmosis
fanconi anaemia
haematopietic stem cell transplantation
Opis:
Toxoplasmosis is an opportunistic infection caused by the parasite Toxoplasma gondii. The infection is severe and difficult to diagnose in patients receiving allogeneic haematopoietic stem cell transplantation (HSCT). It frequently involves the central nervous system. The case is presented of cerebral toxoplasmosis in a 17-year-old youth with Fanconi anaemia treated with haematopoietic stem cell transplantation (HSCT).
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Phenotypic characteristics of feline adipose-derived stem cells affected by cell passage number
Autorzy:
Panasophonkul, S.
Samart, P.
Kongon, K.
Sathanawongs, A.
Powiązania:
https://bibliotekanauki.pl/articles/2087880.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
adipose-derived stem cell
feline
phenotypic characteristic
cell passage number
Źródło:
Polish Journal of Veterinary Sciences; 2017, 4; 651-660
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pneumonia in patients after hematopoietic stem cell transplantation
Autorzy:
Styczyński, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1062942.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
amphotericin B lipid complex
chemotherapy
hematopoietic stem cell transplantation
invasive fungal disease
invasive fungal infection
pneumonia
pulmonary aspergillosis
Opis:
Pneumonia is one of the most frequent cause of death after hematopoietic stem cell transplantation (HSCT). The objective of this review is to present various aspects of pneumonia in this group of patients, with focus on invasive pulmonary aspergillosis and cytomegalovirus disease, being the most frequent etiological causes of pneumonia after HSCT. The review is aimed at practical approach to diagnostic and therapeutic management of pneumonia after HSCT with special attention to: definitions of infections and level of diagnosis of upper and lower respiratory tract infections, including issues specific for invasive fungal disease, pneumocystosis, cytomegalovirus disease, community acquired respiratory viral infections and bacterial pneumonia. Another topics analyzed in the review are: epidemiology and risk factors for development of infection and risk of death due to pneumonia; invasive and non-invasive diagnostics, including imaging and laboratory biomarkers; methods of pharmacological and environmental prophylaxis and specific targeted therapy of pneumonia after HSCT.
Źródło:
OncoReview; 2017, 7, 3; 126-138
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Invasive pulmonary aspergillosis in a child with acute myeloid leukaemia: pharmacotherapy and surgical management
Autorzy:
Styczyński, Jan
Powiązania:
https://bibliotekanauki.pl/articles/1064789.pdf
Data publikacji:
2016
Wydawca:
Medical Education
Tematy:
amphotericin B lipid form
chemotherapy
haematopoietic stem cell transplantation
invasive fungal disease
invasive fungal infection
pulmonary aspergillosis
Opis:
This paper reports on diagnostic and therapeutic management of pulmonary invasive fungal disease (IFD) in a child with relapsed acute myeloid leukaemia, undergoing chemotherapy followed by haematopoietic stem cell transplantation. Surgical management with resection of the involved lung tissue was based on the location of fungal infiltrates close to large circulatory vessels. After examination of resected pulmonary tissue, a diagnosis of proven IFD was done. This case report is an example that aspergillosis is usually the cause for pulmonary IFD. Pharmacotherapy of pulmonary IFD should be based on compounds with good penetration to lung tissue: amphotericin B lipid form or voriconazole.
Źródło:
OncoReview; 2016, 6, 4; A169-174
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
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