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Wyszukujesz frazę "scaffolds" wg kryterium: Temat


Tytuł:
Effect of vascular scaffold composition on release of sirolimus
Autorzy:
Jelonek, K.
Dobrzyński, P.
Kasperczyk, J.
Jaworska, J.
Pastusiak, M.
Sobota, M.
Włodarczyk, J.
Karpeta-Jarząbek, P.
Powiązania:
https://bibliotekanauki.pl/articles/285866.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
vascular
scaffolds
composition
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 30
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The in vitro analysis of scaffolds with glycosaminoglycans addition
Autorzy:
Kaczmarek, B.
Sionkowska, A.
Łukowicz, K.
Osyczka, A. M.
Unrod, V.
Powiązania:
https://bibliotekanauki.pl/articles/283839.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
polysaccharides
collagen
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 28
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impact of carbon nanoforms on hiPSC-derived cardiomyocytes
Autorzy:
Benko, A.
Andrysiak, K.
Fraczek-Szczypta, A.
Stepniewski, J.
Dulak, J.
Powiązania:
https://bibliotekanauki.pl/articles/284044.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
carbon
NCs
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 109
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mechanical properties of composite scaffolds from poly(3-hydroxybutyrate) and sodium alginate
Autorzy:
Bonartsev, A.
Zhuikov, V.
Zharkova, I.
Akoulina, E.
Voinova, V.
Bonartseva, G.
Shaitan, K.
Powiązania:
https://bibliotekanauki.pl/articles/970966.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
polymers
biodegradation
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 89
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biological evaluation of β-1,3-glucan/HA bone scaffold fabricated via new method
Autorzy:
Klimek, K.
Przekora, A.
Ginalska, G.
Powiązania:
https://bibliotekanauki.pl/articles/284634.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
curdlan
scaffolds
biomaterials
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 52
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of PCL and PCL/HAp scaffolds processed by electrospinning and porogen leaching techniques
Autorzy:
Rajzer, I.
Powiązania:
https://bibliotekanauki.pl/articles/283996.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
electrospinning
leaching
Opis:
In order to improve the pore size of the polycapro-lactone (PCL) and polycaprolactone/hydroxyapatite (PCL/HAp) nanofibrous scaffolds, salt-leaching technique together with electrospinning method were applied. Salt particles were incorporated within the polymer nanofibrous matrix and then were leached out to generate some macropores. Microstructure, pore size distribution and average fibre diameter of the scaffold were investigated by scanning electron microscopy and PMI capillary flow porometer. Mechanical properties were determined by means of tensile test. Presence of hydroxyapatite and chemical characterization of the scaffold were done by FTIR analysis.
Źródło:
Engineering of Biomaterials; 2011, 14, 103; 4-7
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation of dependencies between printing parameters in additive manufacturing and properties of materials used for IT
Autorzy:
Bartniak, M.
Przybyszewska, K.
Sobczak, K.
Bociąga, D.
Powiązania:
https://bibliotekanauki.pl/articles/284111.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bioprinting
hydrogels
scaffolds
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 94
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Skafoldy hydroksyapatytowe i kompozytowe wytwarzane metodą robocasting
Development of hydroxyapatite and hydroxyapatite/polymer composite scaffolds by robocasting
Autorzy:
Gryń, K.
Chłopek, J.
Powiązania:
https://bibliotekanauki.pl/articles/284578.pdf
Data publikacji:
2009
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
skafoldy kompozytowe
skafoldy hydroksyapatytowe
metoda robocasting
composite scaffolds
hydroxyapatite scaffolds
Robocasting
Opis:
W celu poprawy własności mechanicznych implantów kostnych a także chęci odtworzenia rozwiązań wypracowanych przez naturę stale prowadzi się poszukiwania nowych materiałów i technologii wytwórczych. W artykule przedstawiono badania nad rusztowaniami hydroksyapatytowymi (HA) i kompozytowymi o kontrolowanej porowatości wykonanymi metodą Robocasting. Celem badań było wytworzenie materiału bazującego na rusztowaniach HA naśladującego strukturalnie naturalną kość, która zbudowana jest z dwóch głównych składników: organicznej macierzy, składającej się głównie z jednorodnie zorientowanych włókien kolagenowych stanowiących ok. 30wt% i porowatego szkieletu mineralnego zbudowanego z fosforanów wapnia (HA) – ok.70wt%. Dzięki takiej budowie kość jest lekka i sztywna a jednocześnie zachowuje elastyczność w pewnym zakresie. To stanowi o jej naturalnej odporności na obciążenia dynamiczne. Porowate rusztowania bioceramiczne, w dużo większym stopniu niż bioceramika gęsta, podatne są na uszkodzenia związane z obciążeniami dynamicznymi. Ich kruchość stanowi poważny problem i znacząco ogranicza stosowanie takich materiałów. Z tego powodu poszukuje się sposobów polepszających ich własności wytrzymałościowe. Opierając się na zasadach biomimetyzmu zdecydowano o wykonaniu kompozytu ceramiczno-polimerowego.
The quest for a better bone implant and mimicing the nature led to a new material preparation. This article presents further research on Robocasting and controlled porosity bioceramic scaffolds. The aim was to fabricate a compo-site material based on hydroxyapatie scaffold. Because natural bone consists of two main compounds: mineral matrix (hydroxyapatite ≈70%) and organic part (mostly collagen fibrils ≈30%). It was decided to strengthen pure HA robocasted scaffolds with the poly-lactide L-glicolide (PGLA 85/15) which is resorbable polymer widely used in medical applications. HA scaffolds were embedded in PGLA. Newly produced composites were tested and results were compared with pure HA scaffolds. Structural and mechanical testing was conducted. It was observed that HA/PGLA composite has much higher values of Fmax and σ when compared with pure HA. Important fact which has to be highlighted is that after compressive test pure HA samples turned into rubble whereas HA/PGLA stayed coherent and kept their shape.
Źródło:
Engineering of Biomaterials; 2009, 12, no. 89-91; 201-204
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bioactive hydroxyapatite ceramics as scaffolds for bone tissue engineering – a preliminary study
Autorzy:
Soukup, D.
Horakova, D.
Sumberova, H.
Andertova, J.
Bacakova, M.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/285204.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydroxyapatite
tissue engineering
scaffolds
Źródło:
Engineering of Biomaterials; 2011, 14, no. 106-108; 13-16
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vaterite CaCO3-coated polymeric fibrous scaffolds for biomedical applications
Autorzy:
Saveleva, M.
Ivanov, A.
Douglas, T. E. L.
Goring, D.
Skirtach, A.
Parakhonskiy, B.
Powiązania:
https://bibliotekanauki.pl/articles/285236.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
polymers
biomedical applications
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 76
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Investigation of influence of internal architecture on mechanical properties of 3D printed scaffolds for bone tissue engineering
Autorzy:
Ostrowska, B.
Święszkowski, W.
Kurzydlowski, K.J.
Powiązania:
https://bibliotekanauki.pl/articles/285974.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
internal architecture
polycaprolactone
Opis:
The aim of the study was to investigate the influence of internal architecture of 3D printed scaffolds on their mechanical properties. The polycaprolactone scaffolds with four different geometries produced by rapid prototyping were tested in this study. The 3D samples were manufactured with different internal architecture. The scaffolds were plotted using a 330 ym dispensing needle, layer by layer with lay-down pattern of the fibers: 00/450/900, 0P/60°/120°, 00/900/1800 and 00/600/1200 with shifted layers. Scanning electron mic¬roscopy analyses and mechanical properties examinations were performed. The mechanical test showed that the highest Young's modulus was obtained for the samples with 0P/6CP/12CP lay-down pattern, especially after layers shifting. The SEM analyzes didn't show any defects or layers delamination in the scaffolds. All the samples were characterized by appropriate 3D architecture and good layers connections. The obtained results confirmed the hypothesis that scaffolds with 00/60°/120l0 lay-down pattern of the fibers and with shifted layers have the highest mechanically properties of the investigated samples and therefore, show high potential to be used in bone tissue engineering application.
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 8-9
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modeling, fabrication and characterization of 3D PLLA scaffolds plotted with commercial printer
Autorzy:
Jablonski, A.
Kopec, J.
Jatteau, S.
Śliwka, M.
Ziąbka, M.
Rajzer, I.
Powiązania:
https://bibliotekanauki.pl/articles/286129.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
medical implants
PLLA
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 84
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nanoengineered hybrid silica/organic nanoparticles and ionized gases for bone regeneration through smart scaffolds
Autorzy:
Thomann, J. S.
Chekireb, M. C. N.
Langueh, C.
Changotade, S.
Rohman, G.
Corne, G.
Duday, D.
Powiązania:
https://bibliotekanauki.pl/articles/286241.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanoparticles
bone regeneration
scaffolds
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 60
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Scaffolds: an attractive concept towards tissue regeneration
Autorzy:
Vandenhaute, M.
Gevaert, E.
Cornelissen, R.
Verfaillie, C.
Dubruel, P.
Powiązania:
https://bibliotekanauki.pl/articles/283821.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
tissue engineering
regeneration
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 124-125
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
GMP compliant isolation and culture of human adipose tissue- derived mesenchymal stem cells for applications in tissue engineering
Autorzy:
Labedz-Maslowska, A.
Szkaradek, A.
Zuba-Surma, E.
Powiązania:
https://bibliotekanauki.pl/articles/284325.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
tissue engineering
cells
scaffolds
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 71
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of fibrin-nanocoating of nanofibrous polymer membranes on the adhesion and proliferation of human dermal fibroblasts
Autorzy:
Pajorova, J.
Bacakova, M.
Musilkova, J.
Stranska, D.
Riedel, T.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/284422.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
polymer membranes
fibroblasts
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 48
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The preliminary studies of a structure and electrospinning of new polyurethanes based on synthetic atactic poly[(R, S)-3-hydroxybutyrate]
Autorzy:
Sajkiewicz, P.
Brzeska, J.
Denis, P.
Sikorska, W.
Kowalczuk, M.
Rutkowska, M.
Powiązania:
https://bibliotekanauki.pl/articles/201693.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
polyurethane
polyhydroxybutyrate
electrospinning
scaffolds
Opis:
Novel polyurethanes based on synthetic, atactic poly[(R, S)-3-hydroxybutyrate] (a-PHB) and polycaprolactone (PCL) or polyoxytetramethylene (PTMG) diols were synthesized. It was shown that the presence of a-PHB within soft segments reduces crystallinity of PUR. Because of the low melting temperature for polyurethanes with PCL in soft segments, at this stage of work, electrospinning was limited to polyurethanes containing PTMG and a-PHB. Polyurethane containing 80% of PTMG and 20% of a-PHB was electrospun at various parameters from hexafluoro-2-propanole solution, resulting in formation of fibers with the average diameter ca. 2 μm. The fiber diameter decreased with decreasing polymer concentration in a solution and was practically insensitive to the needle-collector distance in the applied range of distances.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2014, 62, 1; 55-60
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymer based scaffolds for tissue regeneration
Autorzy:
Gloria, A.
Guarino, V.
Raucci, M. G.
Dantis, R. de
Ambrosio, L.
Powiązania:
https://bibliotekanauki.pl/articles/284812.pdf
Data publikacji:
2009
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polymers
scaffolds
tissue regeneration
Opis:
To attain a successful ECM analogue scaffold, there are several design and material criteria that must be satisfied involving the mimicking of topographical features and geometry on the macro-, micro- and even at nanoscale levels, because each influences cell response to the scaffold. In the last years, a successful approach has been represented by the use of composite scaffolds obtained by a combination of phase inversion, salt leaching, filament winding technology. These techniques enable obtaining porous scaffold with controlled micro and macro porosity able to influence positively mechanical properties and cell interactions. In particular, composite materials based on biodegradable polymers (i.e. poly-ε-caprolactone) endowed with intrinsically bioactive particles (i.e. calcium phosphates) and/or macromolecules (i.e Hyaluronic Acid), offers the possibility to realize a strong bond with natural tissues through more bioactive, structurally and mechanically efficient interfaces, firstly enhancing the capability of the substrate to form new extracellular matrix (ECM) and assuring a more rapid and efficacious integration to the implant site. However, some limitations of traditional process impose to identify innovative strategies for fabricating micro and nanostructures structures. In this context, interesting approaches based on the assembly of basic components or building blocks endowed with molecular signals are powerfully emerging to form hierarchically complex structures, able to accurately recapitulate the functional properties of natural complex structures. For connective tissue regeneration (bone, ligaments, meniscus) compo-site scaffolds are obtained by phase inversion, salt leaching and RP technique to modulate mechanical properties and cell interactions. Design of bioactive scaffolds for bone regeneration with appropriate porosity and high pores interconnectivity could be obtained by using Poly(ε-caprolactone) reinforced with Calcium Phosphates particles and PLA fibres. Ester of Hyaluronic Acid reinforced with degradable fibres were processed by composite technology, phase inversion and salt leaching technique to obtain scaffolds for meniscus regeneration. In vivo results demonstrated the possibility to regenerate the meniscus by using an appropriate scaffolds. Imaging and rapid prototyping technologies are implemented to design a “custom made” meniscus scaffold. A critical discussion on the advantages of new approaches has been performed by proposing strategies based on composite to the assembly of elementary components such as fibres implemented through modified electrospinning or sintering techniques.
Źródło:
Engineering of Biomaterials; 2009, 12, no. 89-91; 1
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dialysis method for β-1,3- glucan gelation provides high biocompatibility of β-1,3-glucan/HA bone scaffold
Autorzy:
Klimek, K.
Przekora, A.
Wójcik, M.
Ginalska, G.
Powiązania:
https://bibliotekanauki.pl/articles/284818.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
dialysis
bone scaffolds
biocompatibility
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 11
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rusztowania hydroksyapatytowe do zastosowań medycznych wykonane metodą “Robocasting” – wstępne testy
Hydroxyapatite scaffolds by “Robocasting” for medical applications – preliminary tests
Autorzy:
Gryń, K.
Chłopek, J.
Powiązania:
https://bibliotekanauki.pl/articles/285043.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
HAp
Robocasting
rusztowania
scaffolds
Opis:
Artykuł prezentuje wyniki wstępnych badań przeprowadzonych na przestrzennych porowatych strukturach bioceramicznych - rusztowaniach hydroksyapatytowych - wykonanych metodą „Robocasting”. Badaniom poddano próbki o różnych wariantach geometrii strukturalnej przy zachowaniu tych samych wymiarów zewnętrznych. Własności wytrzymałościowe wyznaczono w próbie trójpunktowego zginania. Złożoną mikro i makro strukturę pokazano na zdjęciach wykonanych przy użyciu mikroskopu skaningowego i optycznego. Wykonano testy w środowisku SBF. Analiza wyników pokazała, że pomimo niskich własności wytrzymałościowych drukowane struktury przestrzenne mogą służyć do zastosowań medycznych. Wystarczająca sztywność, odpowiednia porowatość, a także biozgodność, pozwala na ich zastosowanie jako rusztowań dla komórek – skafoldów.
Preliminary results on three-dimensional porous bioceramic structures - hydroxyapatite scaffolds - are presented in this article. “Robocasting” was used as a fabrication method. Sets of prepared samples had the same outer diameter but different structure of macroporosity. 3-pts bending test was applied to reveal mechanical properties. Optical microscope and scanning electron microscope (SEM) pictures were taken for structural analysis of printed and sintered samples. Biological activity was tested in simulated body fluid (SBF). Analyses show that low mechanical properties of three-dimensional porous structures are not decisive and do not exclude such structures from medical applications. Sufficient stiffness, appropriate porosity and biocompatibility allow using them as scaffolds for bone cells growth.
Źródło:
Engineering of Biomaterials; 2008, 11, 76; 13-16
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of the sterilization process on the microscopic structure of hyaluronic acid-based nanofibrous scaffolds
Autorzy:
Boguń, M.
Kadłubowski, S.
Pabjańczyk-Wlazło, E.
Szparaga, G.
Chrzanowski, M.
Krucińska, I.
Powiązania:
https://bibliotekanauki.pl/articles/285940.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hyaluronic acid
scaffolds
sterilization
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 65
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of internal architecture on mechanical properties of polycaprolactone scaffolds for tissue regeneration
Autorzy:
Ostrowska, B.
Święszkowski, W.
Kurzydłowski, K.J.
Powiązania:
https://bibliotekanauki.pl/articles/285988.pdf
Data publikacji:
2014
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
tissue regeneration
biomaterials
Opis:
The aim of the study was to investigate the influence of internal architecture of 3D printed scaffolds on their mechanical properties. The polycaprolactone scaffolds with six different internal architectures fabricated by rapid prototyping method were tested in this study. The scaffolds were plotted using a 330 μm dispensing needle, layer by layer with lay-down pattern of the fibers: 00/150/300; 00/300/600; 00/450/900, 00/600/1200, 00/750/1500 and 00/900/1800. Morphological analyses and mechanical properties examinations were performed. The obtained scaffolds had structures with high open porosity (50-60%) and interconnected pores ranging from 380 to 400 μm. The different lay-down pattern and the angle deposition of successive fiber layers resulted in different internal architecture and pore shape of the constructs, what was confirmed by scanning electron microscopy and microtomography analyzes. The geometries 00/900/1800 and 00/600/1200 were characterized with the most regular shape of pores between all analyzed architectures. The pores for 00/150/300 and 00/300/600 were not regular and arranged as a ladder-like helicoid structures. The lay-down pattern of the fibers affected significantly the mechanical properties of the scaffolds. The Young’s modulus (E) of the scaffolds was increasing with increase of the angle deposition between successive layers. The scaffolds were also subjected to cyclic loading and again geometry and mechanical properties were under investigation. For all type of scaffolds the differences of mechanical properties after dynamic compression have been noticed. The geometries 00/900/1800 and 00/600/1200 exhibited the highest Young’s Modulus after dynamic compression according to the rest of analyzed samples. According to the conducted research there is a clear correlation between internal architecture of polymeric scaffolds and their mechanical properties.
Źródło:
Engineering of Biomaterials; 2014, 17, no. 128-129; 8-9
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adhesion and growth of vascular cells on porous polyethylene terephthalate scaffolds
Autorzy:
Havlikova, J.
Turek, K.
Dajko, G.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/283781.pdf
Data publikacji:
2010
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polymers
scaffolds
vascular cells
Opis:
Polymers such as polyethylene terephthalate (PET) have been used for large-caliber vascular prostheses with a relative success but their application is limited in small-caliber grafts. Blood vessel grafts with an internal diameter smaller than 6 mm are prone to fail mainly due to their thrombogenicity and poor haemodynamics. One of the possible solutions of these problems may be reconstruction of the tunica intima and media on the synthetic grafts. For this purpose, special PET foils were prepared. Six-μm thick foils were irradiated by copper ions or fission fragments from a radionuclide etalon source 252Cf and etched by 1M sodium hydroxide to obtain holes of a defined diameter (from 80 to100 nm in foils irradiated by copper ions and from 1.0 to 1.5 μm in foils irradiated by fission fragments) and density (1x106 cm-2 - fission fragments to 5x108 cm-2 – copper ions) (FIG.1). Afterward these materials were seeded with vascular smooth muscle cells (VSMC) derived from the rat aorta, or endothelial cells of the line CPAE. Adhesion, proliferation and viability of the cells were monitored after one, three and seven days. The cell proliferation was evaluated by changes in the cell number in several time intervals and construction of growth curves. Determination of cell viability was based on staining of live cells with calcein emitting green fluorescence, and the dead cells with ethidium bromide emitting red fluorescence. Experiments with the growth of vascular smooth muscle cells and endothelial cells on the PET scaffolds with different pore size showed that endothelial cells prefer pores around 1 μm while VSMC have no preferences concerning the pore size of the polymer scaffolds tested. Although the highest cell population densities were found on the glass coverslips used as control material, the number of cells growing on pristine PET did not differ from the densities on PET foils irradiated by Cu-ions or fission fragments of Cf. The obtained data showed applicability of our improved polymer foils as supporting scaffolds for vascular cells. In the further step, these porous PET membranes could serve as synthetic analogues of internal elastic lamina separating vascular smooth muscle cells and endothelial cells in a newly constructed bioartificial vascular wall.
Źródło:
Engineering of Biomaterials; 2010, 13, no. 99-101; 108-109
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Properties of bilayer gelatin/polycaprolactone scaffolds
Autorzy:
Rajzer, I.
Powiązania:
https://bibliotekanauki.pl/articles/283923.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
composites
tissue engineering
Opis:
In this study, nanofibrous composite scaffolds have been fabricated in order to mimic the physical architecture of native extracellular matrix. Gelatin is a good candidate to mimic the chemical composition of natural collagen. It has many integrin-binding sites for cell adhesion and differentiation, which are found in collagen. However, electrospun scaffold made of gelatin had very poor mechanical properties. Therefore, in this study, bilayer nanofibrous scaffolds made of gelatin and poly(caprolactone) were produced by sequential electrospinning. The microscopic morphology, mechanical properties and porosity of electrospun bilayer gelatin/polycaprolactone scaffold were investigated.
Źródło:
Engineering of Biomaterials; 2011, 14, 104; 2-4
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of temperature and pore size on cell growth and proliferation on hydroxyapatite scaffolds
Autorzy:
Soukup, D.
Bacakova, M.
Pabst, W.
Gregorova, E.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/284010.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
biomaterials
porous biomaterials
scaffolds
Opis:
Porous biomaterials, especially synthetic porous ceramics, are of significant importance in bone tissue engineering, and there has been rapid growth in the medical use of these biomaterials over the last 50 years. The reason is that they are relatively easy to prepare and are available in unlimited supply, unlike the allografts and autografts that are used in clinical practice. Various hydroxyapatite (HAp) scaffolds can be prepared, using various pore-forming techniques and firing temperatures. The firing temperature significantly affects microstructural parameters such as total porosity, pore size, the interconnected pore network, and also the chemical and phase composition. Last but not least, it also affects the mechanical properties of the samples. Knowledge about these factors is therefore essential for designing a sample with the desired controlled microstructure and properties. In this work, uniaxial pressing has been used for preparing HAp disks from nanocrystalline HAp powder, using saccharose as a pore-forming agent. The highest porosity achieved (after partial sintering at 800°C) was in the range of 64.7-70.6%. The firing temperature significantly affects porosity, pore size, grain size and mechanical strength, whereas the dwell time has only a minor effect on these parameters. After firing, XRD confirmed more than 98.4% HAp in all cases. Mercury porosimetry confirmed the presence of nanosized interstitial voids for partially sintered materials and pore throat sizes of approximately 100μm (much smaller than the pore cavities), which is adequate for bone cell penetration and further ingrowth. After firing at 1200°C, the matrix is more or less fully sintered, and nanosized pores are absent or closed. The biological part of the paper summarizes the results from cell-seeding and cultivation experiments to determine the cell adhesion, proliferation, viability, mitochondrial activity and osteogenic cell differentiation on the scaffolds, and thus the biocompatibility and bioactivity of the scaffolds. The highest values for all these parameters, particularly the number of cells, were on HAp fired at 1200°C. The samples fired at 1200°C were prepared with various pore sizes (in the range of 100 - 800μm). We found that pore size has a non-significant effect on cell colonization, whereas the firing temperature has a major influence. All tested HAp samples showed a remarkable ability to adsorb proteins on their surfaces, namely albumin and fibronectin, and to promote cell adhesion. Some cytotoxic activity was observed on the samples fired at 800 and 1000°C. Possible reasons for this cytotoxicity have been discussed. However, it can be concluded that the HAp samples created in this study and fired at 1200°C hold great promise for bone tissue engineering.
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 127
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
3D elastomeric scaffolds for cardiac regeneration
Autorzy:
Sonseca, A.
McClain, A.
Puskas, J. E.
EL Fray, M.
Powiązania:
https://bibliotekanauki.pl/articles/284690.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
cardiac regeneration
scaffolds
elastomeric composites
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 31
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymeric scaffolds with controlled microstructure and surface chemistry: mechanical and physico-chemical characterisation and in vivo evaluation
Autorzy:
Pamuła, E.
Menaszek, E.
Orzelski, M.
Silmanowicz, P.
Krok, M.
Rumian, Ł.
Dobrzyński, P.
Powiązania:
https://bibliotekanauki.pl/articles/285574.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polimery
polymeric scaffolds
resorbable polymers
Źródło:
Engineering of Biomaterials; 2011, 14, 105; 2-4
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Innovative macroporous chitosan/agarose matrix-based biomaterial for bone tissue engineering applications
Autorzy:
Kazimierczak, P.
Pałka, K.
Ginalska, G.
Przekora, A.
Powiązania:
https://bibliotekanauki.pl/articles/285776.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
biomaterials
bone tissue engineering
scaffolds
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 13
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rheological aspects of the flow of thermosensitive chitosan systems during injection application
Autorzy:
Rył, Anna
Owczarz, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1034161.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan scaffolds
injectability
thermosensitive hydrogels
Opis:
The aim of this paper was to conduct preliminary instrumental tests to determine the possibility of injection applications for thermosensitive chitosan systems, including injection needles and application conditions. Among the many biomedical and pharmaceutical applications of chitosan, the minimally invasive thermosensitive scaffolds that form in vivo are an interesting solution. Despite many studies on colloidal chitosan systems undergoing sol-gel phase transition, almost no studies have examined their injectability. It has been stated that the use of acetic acid as a solvent reduces the forces needed for injection. Moreover, the key impact of injection temperature was determined. Storing the medium at room temperature before the injectability test led to a decrease in the value of forces needed for injection. The obtained results are discussed based on the change of the rheological properties of the chitosan hydrogels.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 201-209
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structural variability of lyophilized collagen-based scaffolds: micro-CT 3D analysis
Autorzy:
Bartos, M.
Suchy, T.
Spanko, M.
Foltan, R.
Powiązania:
https://bibliotekanauki.pl/articles/286100.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bone tissue engineering
scaffolds
regeneration
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 24
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tomographic and histological assessment of bone regeneration in the experimental defects in rabbit femoral trochlea treated with resorbable scaffolds
Autorzy:
Pamuła, E.
Menaszek, E.
Malisz, P.
Dobrzyński, P.
Orzelski, M.
Silmanowicz, P.
Powiązania:
https://bibliotekanauki.pl/articles/283854.pdf
Data publikacji:
2010
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bone regeneration
scaffolds
resorbable materials
Źródło:
Engineering of Biomaterials; 2010, 13, no. 99-101; 123-124
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carbon allotropes for muscle regeneration
Autorzy:
Sawosz, E.
Hotowy, A.
Mitura, K.
Grodzik, M.
Wierzbicki, M.
Kutwin, M.
Jaworski, S.
Chwalibog, A.
Powiązania:
https://bibliotekanauki.pl/articles/283864.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
carbon allotropes
muscle regeneration
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 49
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Designing and preparing by FDM 3D printing of polymeric scaffolds with potential application in tissue engineering
Autorzy:
Marchewka, J.
Laska, J.
Powiązania:
https://bibliotekanauki.pl/articles/283921.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polymeric scaffolds
tissue engineering
biodegradation
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 37
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The dependence of mechanical properties on TiO2 nanoparticles concentration in hybrid hydrogel materials with potential use as bones scaffolds
Autorzy:
Zazakowny, K.
Lewandowska-Łańcucka, J.
Mastalska-Popławska, J.
Kamiński, K
Kusior, A.
Nowakowska, M.
Radecka, M.
Powiązania:
https://bibliotekanauki.pl/articles/284246.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
hydrogels
scaffolds
TiO2 nanoparticles
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 36
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nanostructured bone-like scaffolds for restoration of trabecular bone remodeling capability
Autorzy:
Nowak, M.
Firkowska, I.
Giersig, M.
Powiązania:
https://bibliotekanauki.pl/articles/202376.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
bone remodeling
biomechanics
nanostructured scaffolds
Opis:
This paper presents the theoretical study about carbon nanotube substrates for tissue engineering and its applications. Because the replacement of bone tissue with artificial tissue can violate the remodeling process completely, the artificial material should not only consist of the same material properties, but also exhibit other characteristics which are equally important and need to be taken into consideration. These are above all the mechanosensation. Besides replacing natural tissue, the nanostructured scaffolds presented in the paper can help the tissue growth by stimulating this process. The developed trabecular bone remodeling simulation method responsible for the nanostructured scaffold behavior is implemented here. Thus, the nanostructured bone-like scaffolds reflect the remodeling capability of the biological system, not only due to their application as replacement of natural tissue, but also due to their effects in the field of mechanosensation.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2011, 59, 1; 57-61
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Porous chitosan structures for medical applications
Autorzy:
Tylman, Michał
Mucha, Maria
Powiązania:
https://bibliotekanauki.pl/articles/1035545.pdf
Data publikacji:
2010
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan scaffolds
lyophilization
tissue engineering
Opis:
The aim of the study was to develop preparation methods of porous chitosan structures and to investigate their morphological properties as well as the kinetics of model substance release (salicylic acid). Chitosan scaffolds were generated using the liophylisation method and the systems obtained were saturated with hydroxyapatite and salicylic acid. Microscopic investigations (optical and electron microscopy) were carried out to examine the morphology of structures and water vapour sorption isotherms were determined to define the influence of hydroxyapatite on the system sorption ability. Additionally, the kinetic curve for the model substance release process (the process of the 1st order) was determined.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2010, 15; 97-106
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Electrospun biomimetic resorbable scaffold
Autorzy:
Rajzer, I.
Piekarczyk, W.
Kwiatkowski, R.
Biniaś, W.
Janicki, J.
Powiązania:
https://bibliotekanauki.pl/articles/285153.pdf
Data publikacji:
2010
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bone tissue engineering
scaffolds
resorbable materials
Źródło:
Engineering of Biomaterials; 2010, 13, no. 99-101; 13-15
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of process-material conditions on the structure and biological properties of electrospun polyvinylidene fluoride fibers
Autorzy:
Zaszczyńska, A.
Sajkiewicz, P. Ł.
Gradys, A.
Tymkiewicz, R.
Urbanek, O.
Kołbuk, D.
Powiązania:
https://bibliotekanauki.pl/articles/200237.pdf
Data publikacji:
2020
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
scaffolds
electrospinning
polyvinylidene fluoride
tissue engineering
Opis:
Polyvinylidene fluoride (PVDF) is one of the most important piezoelectric polymers. Piezoelectricity in PVDF appears in polar b and ɣ phases. Piezoelectric fibers obtained by means of electrospinning may be used in tissue engineering (TE) as a smart analogue of the natural extracellular matrix (ECM). We present results showing the effect of rotational speed of the collecting drum on morphology, phase content and in vitro biological properties of PVDF nonwovens. Morphology and phase composition were analyzed using scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR), respectively. It was shown that increasing rotational speed of the collector leads to an increase in fiber orientation, reduction in fiber diameter and considerable increase of polar phase content, both b and g. In vitro cell culture experiments, carried out with the use of ultrasounds in order to generate electrical potential via piezoelectricity, indicate a positive effect of polar phases on fibroblasts. Our preliminary results demonstrate that piezoelectric PVDF scaffolds are promising materials for tissue engineering applications, particularly for neural tissue regeneration, where the electric potential is crucial.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2020, 68, 3; 627-633
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hyaluronic electrospun membranes as active scaffolds for bone and cartilage tissue
Autorzy:
Menaszek, E.
Stodolak-Zych, E.
Boguń, M.
Powiązania:
https://bibliotekanauki.pl/articles/284928.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
biomimetics
scaffolds
bone tissue
cartilage tissue
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 93
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Impact of sintering temperature of hydroxyapatite on biological and physicochemical properties of alginate/HA biomaterials for regenerative medicine applications
Autorzy:
Kazimierczak, P.
Syta, E.
Sochan, J.
Ginalska, G.
Przekora, A.
Powiązania:
https://bibliotekanauki.pl/articles/284206.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
ion reactivity
bone scaffolds
alginate
water uptake
Opis:
Synthetic hydroxyapatite (HA) has gained considerable attention in regenerative medicine over recent decades. It is widely used as a bone filler and constituent of various biomaterials. HA possesses high biocompatibility, osteoconductivity, bioactivity, and bioresorbability. There are many different synthesis methods for HA described in the available literature. It is worth noticing that even slight changes in pH, reaction conditions or chemical composition during synthesis, can influence biological, physicochemical, and mechanical properties of resultant HA. The aim of this study was to evaluate the impact of sintering temperature of hydroxyapatite on biological and physicochemical properties of biomaterial made of alginate and hydroxyapatite granules. Alginate/HA material was produced using HA sintered at temperature of 800oC and HA sintered at temperature of 1150oC. Microstructure of the fabricated biomaterials was visualized by SEM. Osteoblast growth on the composites was assessed using human foetal osteoblast cell line. Moreover, ion reactivity, plasma/serum protein adsorption ability as well as water/NaCl uptake capability of the biomaterials were compared. Obtained results demonstrated that although both biomaterials had the same chemical composition, composite comprising hydroxyapatite sintered at temperature of 1150oC had smoother surface, revealed lower ion reactivity, was more favourable to osteoblast growth, and adsorbed lower amount of fibrinogen (which is known to promote biomaterial-induced inflammatory response), compared to the material made of hydroxyapatite sintered at temperature of 800oC. Thus, the type of bioceramics used for the production of biomaterials should be tailored to their specific applications – bone fillers for primarily in vivo implantation or in vitro cell-seeded scaffolds.
Źródło:
Engineering of Biomaterials; 2018, 21, 145; 16-19
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of repair of osteochondral defects in rabbits using new composite biomaterials during three-month observation
Autorzy:
Żylińska, B.
Stodolak-Zych, E.
Nowicka, K.
Silmanowicz, P.
Powiązania:
https://bibliotekanauki.pl/articles/284436.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
osteochondral defects
regenerative medicine
scaffolds
hydroksyapatite
alginate
Opis:
In this work nanocomposite porous pins were implanted into rabbit knees. The pins were made of biodegradable synthetic poly-L/DL-lactide (80:20) which was modified with nanometric hydroksyapatite particles (HAp) and covered with biopolymer layer of sodium alginate (NA). In vivo experiments were conducted on a 4-element group of the New Zealand rabbits. Osteogenesis was observed using scanning electron microscope (SEM/EDS) after 12 weeks of implantation.
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 118-119
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of texture profile analysis to investigate the mechanical properties of thermosensitive injectable chitosan hydrogels
Autorzy:
Owczarz, Piotr
Rył, Anna
Wichłacz, Żaneta
Powiązania:
https://bibliotekanauki.pl/articles/1034254.pdf
Data publikacji:
2019
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
TPA
chitosan
hydrogels
injectable scaffolds
mechanical properties
Opis:
In this paper, the mechanical properties of hybrid chitosan hydrogels were investigated using the texture profile analysis test. Scaffolds obtained from a polysaccharide of various molecular weights were studied, which, with the addition of glycerophosphate salt, formed a three-dimensional structure in vivo. The obtained systems were also enriched with collagen and calcium carbonate to improve the mechanical properties. The determined texture parameter values indicate that the mechanical properties of the hybrid hydrogel depend on the molecular weight of the polymer, the type of solvent and, the pH-neutralizing substance, as well as the type and concentration of the filler. Moreover, in some cases the TPA test was the only way to evaluate the mechanical properties of the obtained hydrogels due to the inability to determine the Young's modulus. Consequently, the texture analysis test is a valuable tool for selecting solutions depending on the intended application of the scaffolds.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2019, 24; 151-163
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of repair of osteochondral defects in rabbits using new composite biomaterials during three-month observation
Autorzy:
Żylińska, B.
Stodolak-Zych, E.
Nowicka, K.
Silmanowicz, P.
Powiązania:
https://bibliotekanauki.pl/articles/285641.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
osteochondral defects
regenerative medicine
scaffolds
hydroksyapatite
alginate
Opis:
In this work nanocomposite porous pins were implanted into rabbit knees. The pins were made of biodegradable synthetic poly-L/DL-lactide (80:20) which was modified with nanometric hydroksyapatite particles (HAp) and covered with biopolymer layer of sodium alginate (NA). In vivo experiments were conducted on a 4-element group of the New Zealand rabbits. Osteogenesis was observed using scanning electron microscope (SEM/EDS) after 12 weeks of implantation.
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 141-143
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of 3D hybrid microfiber/nanofiber scaffolds for bone tissue engineering
Autorzy:
Ostrowska, B.
Jaroszewicz, J.
Zaczyńska, E.
Tomaszewski, W.
Swieszkowski, W.
Kurzydłowski, K. J.
Powiązania:
https://bibliotekanauki.pl/articles/200803.pdf
Data publikacji:
2014
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
rapid prototyping
RP
Electrospinning
ESP
Hybrid scaffolds
Opis:
Fabrication of scaffolds for tissue engineering (TE) applications becomes a very important research topic in present days. The aim of the study was to create and evaluate a hybrid polymeric 3D scaffold consisted of nano and microfibers, which could be used for bone tissue engineering. Hybrid structures were fabricated using rapid prototyping (RP) and electrospinning (ES) methods. Electrospun nanofibrous mats were incorporated between the microfibrous layers produced by RP technology. The nanofibers were made of poly(L-lactid) and polycaprolactone was used to fabricate microfibers. The micro- and nanostructures of the hybrid scaffolds were examined using scanning electron microscopy (SEM). X-ray microtomographical (μCT) analysis and the mechanical testing of the porous hybrid structures were performed using SkyScan 1172 machine, equipped with a material testing stage. The scanning electron microscopy and micro-tomography analyses showed that obtained scaffolds are hybrid nanofibers/microfibers structures with high porosity and interconnected pores ranging from 10 to 500um. Although, connection between microfibrous layers and electrospun mats remained consistent under compression tests, addition of the nanofibrous mats affected the mechanical properties of the scaffold, particularly its elastic modulus. The results of the biocompatibility tests didn’t show any cytotoxic effects and no fibroblast after contact with the scaffold showed any damage of the cell body, the cells had proper morphologies and showed good proliferation. Summarizing, using RP technology and electrospinning method it is possible to fabricate biocompatible scaffolds with controllable geometrical parameters and good mechanical properties.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2014, 62, 3; 551-556
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Obrazowanie trójwymiarowych rusztowań kostnych zasiedlonych komórkami macierzystymi
Three-dimensional imaging of bone scaffolds seeded with stem cells
Autorzy:
Szlązak, K.
Chlanda, A.
Rębiś, J.
Idaszek, J.
Kublik, Ż.
Jaroszewicz, J.
Woźniak, M. J.
Święszkowski, W.
Powiązania:
https://bibliotekanauki.pl/articles/278791.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Inżynierii Materiałów Polimerowych i Barwników
Tematy:
inżynieria biomedyczna
biomateriał
materiał polimerowy
rusztowania polimerowe
rusztowania kompozytowe
rusztowania kostne
komórki macierzyste
obrazowanie
PHBV
PLGA
TCP
biomedical engineering
biomaterial
polymeric material
polymeric scaffolds
composite scaffolds
bone scaffolds
stem cells
imaging
Opis:
W pierwszym etapie niniejszej pracy wytworzono i zasiedlono agregatami komórek macierzystych innowacyjne biomateriały. Rusztowania wykonano z mieszaniny poli(3-hydroksymaślanu-ko-3-hydroksywalerianu) (PHBV), poli(L-laktydu-ko-glikolidu) (PLGA) oraz trójfosforanu wapnia (TCP). W drugim etapie pracy, scharakteryzowano wytworzone biomateriały wykorzystując techniki rentgenowskiej mikrotomografii komputerowej z użyciem środka kontrastującego. Poddano je także analizie powierzchniowej przy pomocy mikroskopu sił atomowych. Wyniki odniesiono do materiału referencyjnego, którym były rusztowania wykonane z PHBV i PLGA. Mikrotomografia komputerowa zapewniła wnikliwą ocenę struktury rusztowań kostnych. Oprócz obrazowania komórek macierzystych umożliwiła obserwację mikrostruktury w całej objętości badanego materiału w 3D. Kolejną techniką szeroko stosowaną do badań rusztowań polimerowych była mikroskopia sił atomowych. Umożliwiła ona wizualną ocenę topografii badanych materiałów oraz analizę ich chropowatości. Wytworzone rusztowania kostne miały odpowiednie parametry dla proliferacji komórek macierzystych. Wyniki niniejszej pracy wykazały, że tomografia komputerowa jest odpowiednim narzędziem do obrazowania komórek macierzystych zasiedlonych na porowatych biomateriałach. Dodatkowo stwierdzono, że specjalnie modyfikowane sondy skanujące umożliwiły dokładniejszy w stosunku do standardowych pomiar chropowatości powierzchni rusztowań.
The first stage of this study involved the preparation and seeding of innovative biomaterials with stem cell Scaffolds through a mixture of poly (3-hydroxybutyrate-co-3-hydroksy-valerat) (PHBV), poly (L-lactide-co-glycolide) (PLGA) and tricalcium phosphate (TCP). In the second stage, biomaterials were characterized using a X-ray computed microtomography (CT) with a contrast agent. They were also subjected to surface analysis using atomic force microscopy. The results were compared to the reference material, of a PHBV/PLGA composite scaffold. The computed microtomography ensured rigorous assessment of the bone scaffold structure. Apart from stem cell imaging it also enabled the observation of the microstructure in the entire volume of the material in 3D. Another technique used to study polymeric scaffold was atomic force microscopy (AFM). It allowed for the visual assessment of the topography of the tested materials, as well as the analysis of their surface roughness. The tested bone scaffolds showed appropriate parameters for stem cell proliferation. The results of this study indicated that tomography is a suitable tool for the imaging of stem cell seeding on porous biomaterials. In addition, we couclude that specially modified scanning probes enabled more accurate surface roughness measurements.
Źródło:
Przetwórstwo Tworzyw; 2014, [R.] 20, nr 1 (157), 1 (157); 100-109
1429-0472
Pojawia się w:
Przetwórstwo Tworzyw
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Degradacja rusztowań kolagenowych w warunkach in vitro
In vitro degradation of collagen scaffolds
Autorzy:
Kozłowska, J.
Sionkowska, A.
Bajek, A.
Rynkiewicz, A.
Powiązania:
https://bibliotekanauki.pl/articles/285274.pdf
Data publikacji:
2013
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
rusztowania kolagenowe
degradacja
kolagen
collagen scaffolds
collagen
degradation
Źródło:
Engineering of Biomaterials; 2013, 16, no. 122-123 spec. iss.; 34-36
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Otrzymywanie i właściwości porowatych trójwymiarowych skafoldów kolagenowych
Preparation and properties of a porous three-dimensional collage scaffolds
Autorzy:
Kozłowska, J.
Sionkowska, A.
Powiązania:
https://bibliotekanauki.pl/articles/285748.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
skafoldy kolagenowe
biomateriały
kompozyty
collagen scaffolds
biomaterials
composites
Źródło:
Engineering of Biomaterials; 2011, 14, no. 109-111 spec. iss.; 22-24
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rusztowania hydroksyapatytowe do zastosowań medycznych wykonane metodą „Robocasting - wstępne testy
Hydroxyapatite scaffolds by „Robocasting for medical applications - preliminary tests
Autorzy:
Gryń, K.
Chłopek, J.
Powiązania:
https://bibliotekanauki.pl/articles/284572.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
rusztowania
hydroksyapatyt
metoda robocasting
hydroxyapatite
hydroxyapatite scaffolds
Robocasting
Opis:
Celem prowadzonych badań było wstępne przebadanie i opisanie własności fizycznych, mechanicznych i biologicznych porowatych rusztowań hydroksyapatytowych wykonanych metodą „Robocasting". Badaniom poddano próbki o różnych wariantach geometrii strukturalnej przy zachowaniu tych samych wymiarów zewnętrznych. Wydrukowano trzy rodzaje próbek: siatka gęsta, siatka rzadka, materiał lity. Własności wytrzymałościowe wyznaczono w próbie trójpunktowego zginania. Stwierdzono, że w porównaniu z kością naturalną własności wytrzymałościowe próbek są niższe i pogarszają wraz ze wzrostem makroporowatości. Złożoną mikro i makro strukturę wydrukowanych i spieczonych próbek pokazano na zdjęciach wykonanych przy użyciu mikroskopu skaningowego (SEM). Nie stwierdzono defektów o innej niż osnowa mikrostrukturze. Materiał po spiekaniu był jednorodny w całej objętości (nawet w miejscach połączenia warstw). Wykonano testy w środowisku SBF (simulated body fluid). Po 8 dniach inkubacji zaobserwowano na powierzchni próbek pojawienie się kalafiorowatych struktur apatytowych, a dodatkowo po 14 dniach narosły kryształy chlorkowe. Po przeprowadzonych analizach stwierdzono, że mimo niskich własności wytrzymałościowych drukowane struktury przestrzenne mogą służyć do zastosowań medycznych. Wystarczająca sztywność, odpowiednia porowatość a także biozgodność pozwala na ich zastosowanie jako rusztowań dla komórek - skafoldów. Dodatkową zaletą metody „Robocasting" jest możliwość wykonywania obiektów o dowolnych kształtach, dzięki czemu idealne dopasowanie implantu np.: do ubytku, który ma być wypełniony, nie nastręcza trudności. Dalsze badania będą nastawione na testy odpowiedzi komórkowej (in vitro i in vivo) w celu dokonania pełnego opisu materiału.
The purpose of this preliminary research was to investigate and describe mechanical properties, micro and macro structure and the behavior in immersion solution of 3D hydroxyapatite structures manufactured by "Robocasting". Three different macrostructures were printed and taken under investigation: fine grid, coarse grid and bulk material. It was observed that mechanical properties of such samples in comparison with natural bone are lower and deteriorate with porosity (the bigger macroporosity the lower mechanical properties). For structural analysis of printed and sintered samples scanning electron microscope (SEM) pictures were taken. No defects, bonding or other imperfection in the macrostructure were found. Material was fully homogenous even in layer-to-layer contact areas. Biological activity was tested in simulated body fluid (SBF). After 8 days of incubation SEM pictures revealed apatite structures formed on the samples' surface. Some chloride crystals were observed after 14 days. Analyses show that low mechanical properties are not decisive and do not exclude such structures from medical applications. Sufficient stiffness, appropriate porosity and biocompatibility allow to use them as scaffolds for bone cells growth. Another big advantage of "Robocasting" is an arbitrary shape of manufactured samples. It gives an opportunity to create scaffold (implant) perfectly fitted e.g. to fill the bone tissue defects. That is why consecutive research will be focused on more accurate tests (in vitro and in vivo) to fully describe of manufactured structures.
Źródło:
Engineering of Biomaterials; 2008, 11, no. 81-84; 76
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bioactivity assessment of ceramic nanoparticels used as a filler in nanocomposite materials
Autorzy:
Gęgotek, K.
Zych, Ł.
Stodolak-Zych, E.
Powiązania:
https://bibliotekanauki.pl/articles/285902.pdf
Data publikacji:
2013
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
nanocomposite
bioactivity
scaffolds
regenerative medicine
bioceramics
zeta potential
Opis:
The paper presents research on degree of bioactivity of nanometric ceramic particles used as a nanofiller in nanocomposite materials based on polymers. The nanoperticles used in our examination were: different bioceramics powders such as: hydroxyapatite (HAp), β-phosphate (V) calcium (βTCP), silica (SiO2) and bioglass (BG). Based on ζ-potential measurements dynamics of processes occurring on the surface of nanoparticles in stimulated body fluid (SBF) was determined and it confirmed possibility of apatite formation. This study showed predominance of bioglass over other bioceramic materials, Bioglass nanoparticles were the most bioactive ones. In the end of the experiment the bioacermic particles were used as a nanofiller of poli-L/DL-lactide (PLDLA) matrix composites. The composite materials were prepared by casting from solution. Bioactivity tests were performed in simulated body fluid (artificial plasma of various ions concentration, and SBF 2SBF). Based on surface microstructure observed in the SEM (EDS) analysis were confirmed the degree of bioactivity of various materials depending on the type nanofiller.
Źródło:
Engineering of Biomaterials; 2013, 16, no. 122-123 spec. iss.; 73-74
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of PCL and PCL/n-HAp fibres processed by melt spinning
Autorzy:
Rajzer, I.
Fabia, J.
Graczyk, T.
Piekarczyk, W.
Powiązania:
https://bibliotekanauki.pl/articles/283872.pdf
Data publikacji:
2013
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
PCL fibres
melt spinning
scaffolds
bone
tissue engineering
Opis:
In this work the process for the manufacture of polycaprolactone fibres containing hydroxyapatite nanoparticles by melt spinning method was developed. The effect of nanohydroxyapatite content on the fibre structure and properties was investigated with FTIR, SEM, DSC, TGA methods. The mechanical properties of obtained fibres enable further processing to scaffolds by nonwoven technologies.
Źródło:
Engineering of Biomaterials; 2013, 16, 118; 2-4
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł

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