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Tytuł:
Acute sinusitis in daily clinical practice
Autorzy:
Arcimowicz, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/23211721.pdf
Data publikacji:
2021-08-26
Wydawca:
Index Copernicus International
Tematy:
acute bacterial sinusitis
acute post-viral sinusitis
acute sinusitis
antibiotic treatment
cold
diagnostics
epidemiology
EPOS
integrated care pathways
intranasal corticosteroids
phytotherapy
rhinosinusitis
treatment
Opis:
Understanding the appropriate use of diagnostics and treatment in acute rhinosinusitis is of immense importance given the high prevalence of this disease in the general population. The ability to differentiate between the principal phenotypes of acute sinusitis, namely acute viral infection (cold), acute post-viral sinusitis and acute bacterial sinusitis, determines the future management and is fundamental to providing rational therapeutic recommendations – especially as regards antibiotic treatment, which is very often overused in acute sinusitis even though bacterial phenotypes only account for 0.5–2% of all cases of the disease. The latest therapeutic recommendations contained in the EPOS2020 position paper introduce a system based on integrated care pathways (ICPs), which comprise pharmacy-supported self-care and e-health as the first level, followed by primary care as the second, with specialist care being reserved for patients who develop a more severe course of the disease, have suspected complications or suffer from recurrent acute sinusitis. Management of acute sinusitis is primarily based on symptomatic treatment modalities, with phytotherapeutic support, as well as on antiinflammatory treatment, while antibiotic therapy is used in very specific and limited indications. Complications are relatively rare in acute sinusitis and they are not considered to be associated with antibiotic intake. Considering the high prevalence of acute forms of sinusitis, their significant impact on quality of life and high direct and indirect costs of treatment, the right diagnosis and management, without unnecessary escalation of therapy, can substantially translate into a number of public health benefits.
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 4; 40-50
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
EPOS2020: What’s new for physician practitioners?
Autorzy:
Arcimowicz, Magdalena
Niemczyk, Kazimierz
Powiązania:
https://bibliotekanauki.pl/articles/1399060.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
acute rhinosinusitis
chronic rhinosinusitis
diagnostics
epidemiology
integrated care pathways
nasal polyps
rhinitis and paranasal sinusitis
treatment
Opis:
The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 also abbreviated to EPOS2020, is the new edition of the European document devoted to the broadly understood topic of inflammation of the nasal mucosa and paranasal sinuses. The first edition appeared in 2005, followed by further editions in 2007 and 2012. In February 2020, we received the latest version, extended, somewhat modified, expanded to include the latest research and meta-analysis in the fields of: rhinology, rhinosurgery, epidemiology and reports on comorbidities. A completely new division of chronic sinusitis was presented. Recommendations based on the highest quality evaluations, resulting from the publication of the last eight years, also introduce a system based on integrated care pathways, or ICP in sinusitis. Chapters on pediatric aspects and sinus surgery have been expanded. EPOS2020 is addressed not only to doctors, but also to: nurses, pharmacists, other healthcare workers, as well as patients themselves, who often make the first attempts at treatment with OTC preparations, frequently based on the recommendations of pharmacists. The latest EPOS also specifies directions for further lines of research in the broadly understood field of rhinosinusitis.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2020, 9, 2; 7-17
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A randomized, double-blind, placebo-controlled study to investigate the use of bacteriophages in patients with chronic rhinosinusitis with nasal polyps
Autorzy:
Dobretsov, Konstantin Grigorievich
Kolenchukova, Oxana
Sipkin, Alexander
Bellussi, Luisa Maria
Ciprandi, Giorgio
Passali, Desiderio
Powiązania:
https://bibliotekanauki.pl/articles/23203235.pdf
Data publikacji:
2021-06-30
Wydawca:
Index Copernicus International
Tematy:
bacteria
bacteriophages
chronic rhinosinusitis with nasal polyps
cytokines
local treatment
Opis:
Introduction: A randomized, double-blind, placebo-controlled study investigates the use of bacteriophages in the treatment of chronic rhinosinusitis with nasal polyps. Material and methods: 40 adult patients with chronic rhinosinusitis with nasal polyps were examined. All patients underwent functional endoscopic sinus surgery. After the surgery, 20 patients were administered an intranasal gel with bacteriophage mixture (Otofag, Micromir, Russia) twice a day for ten weeks, while 20 other patients received a placebo solution. Results: On the 10th day, IL-1β secretion diminished (63 mg/ml versus 440 mg/ml in control). There was a decrease in the total number of microorganisms and Enterobacteriaceae (5.7 x 106 CFU/ml versus 1.2 x 109 CFU/ml in the control group) and the absence of Streptococci (versus 2.1 x 109 CFU/ml in control) was noted on the 30th day of treatment in the group receiving bacteriophage mixture. On the 10th day, a decrease in the activity of secretory IL-1β and IL-8 strongly and very strongly correlated with a total number of microorganisms (r = 0.7; r = 0.9, respectively), as well as a decrease in the activity of secretory IL-8 correlated with the number of Enterobacteriaceae (r = 0.72) and Staphylococci (r = 0.65) in the experimental group treated with bacteriophages. On the 30th day, the decrease in serum IL-1β significantly correlated with the total number of microorganisms (r = 0.80) and Enterobacteriaceae (r = 0.90) in the experimental group. Conclusions: The administration of bacteriophages restored the balance of microorganisms in the nasal cavity and decreased inflammatory response in chronic rhinosinusitis with nasal polyps. Changes such as an inflammation dampening could potentially contribute to reducing recurrent growth of polyp tissue in the future.
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 6; 33-37
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Biologicals in the treatment of chronic rhinosinusitis with nasal polyps – position of the Polish Society of Otorhinolaryngologists – Head and Neck Surgeons and the Polish Society of Allergology experts
Leki biologiczne w leczeniu przewlekłego zapalenia błony śluzowej nosa i zatok przynosowych z polipami nosa – stanowisko ekspertów Polskiego Towarzystwa Otorynolaryngologów Chirurgów Głowy i Szyi oraz Polskiego Towarzystwa Alergologicznego
Autorzy:
Jurkiewicz, Dariusz
Kupczyk, Maciej
Brożek-Mądry, Eliza
Rapiejko, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/27320992.pdf
Data publikacji:
2023-10-03
Wydawca:
Index Copernicus International
Tematy:
biological treatment
chronic rhinosinusitis
T2-diseases
choroby T2-zależne
leki biologiczne
przewlekłe zapalenie zatok przynosowych
Opis:
Chronic rhinosinusitis with nasal polyps (CRSwNP) has a significant impact on the well-being and social functions of the patient. The generalized inflammatory process with the formation of nasal polyps and excess eosinophils in the mucosa of the paranasal sinuses is called type 2 inflammation, which is mediated by Th2 lymphocytes – cells of the immune system responsible for chronic inflammatory processes. Today, we also know the key pro-inflammatory mediators against which new drugs have been developed, the so-called biological drugs, are produced in cell lines. In this document, we present currently available biologicals approved for the treatment of patients with T2-related chronic rhinosinusitis.
Przewlekłe zapalenie błony śluzowej nosa i zatok przynosowych z polipami nosa (PZZPzPN) wywiera duży wpływ na samopoczucie i funkcje społeczne chorego. Uogólniony proces zapalny przebiegający z powstawaniem polipów nosa i nadmiarem eozynofilów w obrębie błony śluzowej zatok przynosowych to zapalenie typu 2., w którym pośredniczą limfocyty Th2 – komórki układu immunologicznego, odpowiadające za przewlekłe procesy zapalne. Dziś znamy też kluczowe mediatory prozapalne, przeciwko którym powstały nowe leki, tzw. leki biologiczne, wytwarzane w liniach komórkowych. W dokumencie przedstawiamy dostępne, w obecnej chwili, leczenie biologiczne zatwierdzone do leczenia pacjentów z T2 – zależnym przewlekłym zapaleniem zatok przynosowych.
Źródło:
Polish Journal of Otolaryngology; 2023, 77, 2; 1-11
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of bacterial resistance during treatment with topical gentamicin for chronic rhinosinusitis in patients with cystic fibrosis and primary ciliary dyskinesis. Retrospective case series
Autorzy:
Kisiel, Marta
Sjölander, Isabella
Klar, Agnes
Asplund Stenkvist, Monika
Laurell, Göran
Powiązania:
https://bibliotekanauki.pl/articles/1397315.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
chronic rhinosinusitis
cystic fibrosis
gentamycin nasal spray
gentamycin resistance
primary ciliary dyskinesis
Opis:
Background: The management of chronic rhinosinusitis (CRS) in patients with cystic fibrosis (CF) and primary ciliary dyskinesia (PCD) is still a challenge. At our institution we have used gentamycin nasal spray, extemporaneously produced, for prophylactic treatment of moderate-to-severe CRS. The aim of this study was to investigate the gentamycin susceptibility of bacteria in sputum samples in CF and PCD patients treated for CRS. Methodology: Patients with CF and PCD who were prescribed gentamycin nasal spray for CRS and had sputum bacterial cultures taken pre-treatment and followed-up at least once after ≥6 months were retrospectively included. Microbiological data were descriptively analysed in terms of bacterial species and resistance to gentamycin. Results: A case series of 17 CF and 12 PCD patients passed the inclusion criteria. Of those cases, three (18%) CF patients and one (8%) PCD patient developed resistance to gentamycin during treatment with gentamycin nasal spray. In all four cases, the resistant bacterial isolates were P. aeruginosa. Additionally, two CF patients already had P. aeruginosa isolates resistant to gentamycin in the pre-treatment culture. In further two CF patients, the multi-resistant Burgdorferi cepacia complex, including gentamycin resistance, was identified. P. aeruginosa and S. aureus in CF and P. aeruginosa and H. influenza in PCD were the predominant bacterial species. Conclusions: The study showed that there was moderate incidence of gentamycin resistance in CF and PCD patients at our institution. However, further prospective studies are needed to confirm the outcomes.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 3; 33-40
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Rola badań mikrobiologicznych w bakteryjnych zakażeniach górnych dróg oddechowych
Role of the microbiology laboratory tests in diagnosis inflammation of the upper respiratory tract
Autorzy:
Kutera-Chrobok, Katarzyna
Klekotka, Renata
Symela-Kaspera, Joanna
Ślaska-Kaspera, Aleksandra
Dziubdziela, Włodzimierz
Markowski, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/1930300.pdf
Data publikacji:
2021-09-07
Wydawca:
Index Copernicus International
Tematy:
badania mikrobiologiczne
ostre zapalenie ucha środkowego
zapalenie gardła i migdałków podniebiennych
zapalenie zatok obocznych nosa
microbiological diagnosis
acute otitis media
acute pharyngotonsillitis
rhinosinusitis
Opis:
Infections of the upper respiratory tract are one of the main reasons why patients visit their primary care physician. Most of these are viral infections, requiring only symptomatic treatment. In the case of infections of bacterial etiology, apart from thorough medical history and physical examination, microbiological tests play an important role. They allow for the precise identification of the microorganism and determine sensitivity to antibiotics. Avoiding unjustified or wrong antibiotic therapy supports the fight against multi-drug resistant organisms, which are an increasing challenge for modern medicine. One of the most common causes of pharyngitis is Streptococcus pyogenes infection. Despite the possibility of performing rapid antigen detection test, pharyngeal culture remains the gold standard in the diagnosis of bacterial infections in this area. Otitis media is considered by the authors as well as sinusitis. The primary ethiology of the otitis media are viruses following the dysfunction of the Eustachian tube, which causes secondary bacterial infection. The anatomical structure of the middle ear prevents direct collection of material for microbiological examination, except in the case of spontaneous perforation of the tympanic membrane or paracentesis. Sinusitis is mostly viral infection and is diagnosed based on clinical symptoms. In the routine diagnosis of rhinosinusitis, microbiological testing is not recommended, however the authors discuss the principles and indications for extending the diagnostics. The following article argues the most common pathogens responsible for infections in the mouth, throat, middle ear, and paranasal sinuses. The authors pay special attention to the quality of the collected material, protection of the sample and the method of transport to the laboratory. Compliance with the following standards in everyday clinical practice may reduce the percentage of non-diagnostic results and will help in making an accurate diagnosis.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2021, 10, 3; 1-5
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The importance of herbal medications in the treatment of rhinosinusitis in adults and children: an example of a five-ingredient herbal medicine
Znaczenie leków roślinnych w leczeniu zapalenia błony śluzowej nosa i zatok przynosowych u dorosłych i dzieci na przykładzie 5-składnikowego leku roślinnego
Autorzy:
Markowski, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/27320988.pdf
Data publikacji:
2023-03-10
Wydawca:
Index Copernicus International
Tematy:
acute post-viral rhinosinusitis
acute rhinosinusitis
acute viral rhinosinusitis
bacterial rhinosinusitis
BNO 1016
chronic rhinosinusitis
Sinupret® extract
Sinupret® treatment of rhinosinusitis
bakteryjne zapalenie zatok przynosowych
leczenie zapalenia zatok
ostre powirusowe zapalenie zatok przynosowych
ostre zapalenie zatok przynosowych
przewlekłe zapalnie zatok przynosowych
Sinupret®
Opis:
This review paper presents current recommendations for the treatment of acute and chronic rhinosinusitis according to the European Position Paper on Rhinosinusitis and Nasal Polyps 2020, EPOS 2020. A particularly important and new element of these recommendations is to emphasize the role of phytotherapy as a rational treatment method, documented by a randomized, double-blind placebo-controlled trial (DBPC). An example of rational phytotherapy of rhinosinusitis is the BNO 1016 formulation recommended in EPOS 2020, known under the trade name of Sinupret®. Each of the pharmaceutical forms of BNO 1016 – coated tablets (powdered drug; dry extract) and oral drops (ethanol extract), is produced on the basis of the same combination of 5 herbal substances such as: gentian root (Gentianae radix), primrose flower (Primulae flos), sorrel herb (Rumicis herba), elderflower (Sambuci flos) and verbena herb (Verbenae herba). BNO 1016 has the status of a drug with well-established therapeutic use, with efficacy and safety confirmed in numerous clinical and preclinical studies. Used in the treatment of acute uncomplicated rhinosinusitis BNO 1016 has antiviral, secretolytic, anti-inflammatory and antibacterial effects confirmed in pharmacological studies. Importantly, the drug Sinupret® can be used in different age groups and therapeutic regimens (mono- and polytherapy), at any stage of sinusitis – from cold disease to bacterial rhinosinusitis (in combination with other drugs).
Niniejsza praca przeglądowa przedstawia aktualne zalecenia leczenia ostrego i przewlekłego zapalenia zatok przynosowych wg Europejskich Wytycznych na temat Zapalenia Zatok Przynosowych i Polipów Nosa, które zostały opublikowane na początku 2020 roku (ang. European Position Paper on Rhinosinusitis and Nasal Polyps 2020; EPOS 2020). Szczególnie istotnym i nowym elementem tych wytycznych jest podkreślenie roli fitoterapii jako racjonalnej metody leczenia, udokumentowanej randomizowanymi badaniami klinicznymi z podwójnie ślepą próbą z kontrolą placebo (ang. double-blind placebo-controlled trial; DBPC). Przykładem racjonalnej fitoterapii zapalenia zatok przynosowych jest rekomendowana w EPOS 2020 formulacja BNO 1016, znana pod nazwą handlową Sinupret®. Każda z postaci farmaceutycznych BNO 1016 – tabletki drażowane (sproszkowany lek; suchy wyciąg) oraz krople doustne (wyciąg etanolowy) – wyprodukowana jest na bazie tego samego złożenia 5 substancji roślinnych, takich jak: korzeń goryczki (Gentianae radix), kwiat pierwiosnka (Primulae flos), ziele szczawiu (Rumicis herba), kwiat bzu czarnego (Sambuci flos) i ziele werbeny (Verbenae herba). BNO 1016 ma status leku o ugruntowanym zastosowaniu leczniczym, skuteczności i bezpieczeństwie stosowania potwierdzonych w licznych badaniach klinicznych i przedklinicznych. Stosowany w leczeniu ostrego niepowikłanego zapalenia zatok przynosowych BNO 1016 wykazuje potwierdzone w badaniach farmakologicznych działanie: przeciwwirusowe, sekretolityczne, przeciwzapalne oraz przeciwbakteryjne. Co ważne, lek Sinupret® może być podawany w różnych grupach wiekowych i schematach terapeutycznych (mono- i politerapia), na każdym etapie zapalenia zatok, począwszy od choroby przeziębieniowej, skończywszy na bakteryjnym zapaleniu zatok przynosowych (w skojarzeniu z innymi lekami).
Źródło:
Polish Journal of Otolaryngology; 2023, 77, 1; 1-8
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Functional endoscopic sinus surgery (FESS) in unilateral sinus disease
Autorzy:
Mielcarek-Kuchta, Daniela
Simon, Karolina
Kondratowicz, Dawid
Łukomska, Zofia
Rybak-Korytowska, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/1398482.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
unilateral sinus disease
FESS
chronic rhinosinusitis
inverted papilloma
mycosis
Opis:
Background: Unilateral sinus disease (USD) occurs in 23 % of all cases. It is believed that it is mainly associated with cancer development. Retrospective data from large rhinological centers show that the most common USD is chronic rhinosinusitis (CRS), followed by mycosis, inverted papilloma and finally cancer, but only in a small percent of cases. The aim of the study: The analysis of USD in the group of patients who underwent FESS at the secondary referral center. Material and Method: The retrospective study of patients treated for USD in the Department of Otolaryngology in the Provincial Hospital in Poznan between June 2014 and June 2016. The analysis includes age, sex, the localization of lesions, histopathological and microbiological results, an extension of the surgery and treatment results. Results: Over the analyzed period of time, 415 FESS for chronic sinusitis were performed. In this group, 83 patients underwent surgery for USD. There were 35 women and 48 men.CRS was found in 48 cases, mycosis in nine cases, 12 patients were operated for non-malignant tumors, such as inverted papilloma (9), osteoma (2) and fibrosis tumor(1); seven patients had a choanal polyp and two of them had a foreign body in maxillary sinus – a tooth root lying loose. Four patients were diagnosed with a hypoplastic maxillary sinus and one patient suffered from frontal sinus pyocele. One side endoscopic opening of all sinuses was performed in the group with CRS, endoscopic medial maxillectomy was conducted in patients with inverted papilloma, and an isolated opening of the affected sinus was performed in the cases with mycosis. Conclusions: USD must be always suspected of malignant degeneration until proven otherwise. Endoscopic sinus surgery with the use of angled scope allows for the removal of even very extensive lesions. In our opinion, the extent of operation is determined by the nature of pathology. While extensive surgery is recommended in patients with inverted papilloma, a limited procedure should be performed in those with isolated mycosis.
Źródło:
Polish Journal of Otolaryngology; 2017, 71, 5; 29-35
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of nasal mucosa irritants on the occurrence of chronic rhinosinusitis without /and with polyps
Autorzy:
Olszewska, Aleksandra
Niewiadomski, Piotr
Olszewski, Jurek
Powiązania:
https://bibliotekanauki.pl/articles/1397254.pdf
Data publikacji:
2021
Wydawca:
Index Copernicus International
Tematy:
chronic rhinosinusitis with/without nasal polyps
irritants
nasal mucosa
Opis:
Introduction: The aim of the study was to assess the effect of nasal mucosa irritants on the occurrence of chronic rhinosinusitis without/and with nasal polyps. Material and methods: The study involved 100 adult participants, including 39 women and 61 men, aged 21–68, diagnosed and treated at the Department of Otolaryngology, ENT Oncology, Audiology and Phoniatrics at the University Clinical Hospital WAM in Łódź. Based on the otorhinolaryngological and imaging (CT) tests they were divided into two groups: I – 50 patients, including 23 women and 27 men, aged 21–64 – with chronic rhinosinusitis without nasal polyps, II – 50 patients, including 16 women and 34 men, aged 22–68 – with chronic rhinosinusitis with nasal polyps. The control group consisted of 50 people (group III), including 25 women and 25 men, aged 18–30, students of the Faculty of Military Medicine at the Medical University of Lodz. All respondents completed a prepared questionnaire consisting of 17 questions addressed in the form of an anonymous interview among patients treated in the Department of Otolaryngology, ENT Oncology, Audiology and Phoniatrics. Results: The conducted surveys indicate the impact of the following factors in pathogenesis of chronic rhinosinusitis without/ with nasal polyps: exogenous factors (viruses, bacteria, fungi, drugs, injuries, toxic substances, environmental pollution), general endogenous factors (allergy, hypersensitivity to acetylsalicylic acid and its derivatives, hormonal disorders, supraesophageal reflux disease, granulation disease, immunity disorders, local endogenous factors. Conclusions: In the examined material, patients with chronic rhinosinusitis without/and nasal polyps in most cases are in the age range 51–60 years and over 60 years, they most often live in large cities over 250 thousand inhabitants, suffer from allergic rhinorhinitis in 38.0% in group I and 36.0% in group II, rapid temperature changes and dry air have a negative impact on comfort of breathing. The conducted surveys confirm that the cause of chronic rhinosinusitis with polyps is multifactorial, but a significant factor affecting typical tissue remodeling in this disease is long-term breathing of polluted atmospheric air.
Źródło:
Polish Journal of Otolaryngology; 2021, 75, 1; 36-44
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zastosowanie substancji pochodzenia naturalnego w leczeniu zapalenia zatok przynosowych w świetle Europejskich wytycznych na temat zapalenia zatok przynosowych i polipów nosa – EPOS 2012
The use of natural substances in the treatment of rhinosinusitis in the light of the European Position Paper on Rhinosinusitis and Nasal Polyps 2012
Autorzy:
Pachecka, Małgorzata
Pachecka, Ryszard
Pławińska, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1033341.pdf
Data publikacji:
2014
Wydawca:
Medical Communications
Tematy:
diagnostic management guidelines
phytotherapy (as adjunct treatment)
rhinosinusitis
treatment
zapalenie błony śluzowej nosa i zatok przynosowych
wytyczne postępowania diagnostycznego
leczenie
fitoterapia (jako leczenie wspomagające)
Opis:
Rhinosinusitis is a very common condition of the upper respiratory tract. The disease may be caused by viral, bacterial or fungal infections as well as by allergens or air pollution (e.g. tobacco smoke), with viral infections being the most common cause. The first phase of viral rhinosinusitis therapy involves the use of antipyretics, analgesics, anti-oedematous agents as well as nasal decongestants, occasionally, topical glucocorticosteroids, nasal irrigation and adjunct phytotherapy. Viral or allergic rhinosinusitis does not require antibiotic therapy. Antibiotics should be used if symptoms persist after 7–10 days or bacterial superinfection develops. More intense treatment (antibiotic, metronidazole, intranasal glucocorticosteroid as well as formulations that dilute mucous secretions and have anti-oedematous effects) for up to several days is necessary in cases of acute rhinosinusitis in children, which is quite often a very serious disease bordering on sepsis (pansinusitis). According to the 2012 European Position Paper on Rhinosinusitis and Nasal Polyps 2012 (EPOS 2012), natural compounds may be used as an adjunct treatment in some cases and in certain periods of the disease. These include nasal irrigation with saline or an appropriate seawater solution as well as the use of herbal medicinal products. The paper discusses in detail the use of different herbal medicinal products and presents literature data related to the efficacy and tolerance of these products.
Zapalenie śluzówki nosa i zatok przynosowych to bardzo częste schorzenie górnych dróg oddechowych. Może być spowodowane zakażeniami wirusowymi, bakteryjnymi, grzybiczymi, alergenami oraz zanieczyszczeniem powietrza (np. dymem tytoniowym); najczęstszą przyczynę stanowią zakażenia wirusowe. W pierwszej fazie leczenie zapalenia śluzówki nosa i zatok przynosowych o etiologii wirusowej polega na stosowaniu leków przeciwgorączkowych, przeciwbólowych, przeciwobrzękowych, udrożniających nos, niekiedy glikokortykosteroidów miejscowo, płukaniu jam nosa oraz wspomagająco fitoterapii. Nie jest konieczne stosowanie antybiotyków w przypadkach wirusowego lub alergicznego podłoża choroby. Jeśli objawy po 7–10 dniach utrzymują się albo dochodzi do nadkażenia bakteryjnego, należy zastosować antybiotyki. W przypadkach ostrego zapalenia zatok przynosowych u dzieci, będącego dość często bardzo poważną chorobą na pograniczu posocznicy (pansinusitis), konieczne jest intensywne leczenie (antybiotyk, metronidazol, glikokortykosteroid donosowo oraz preparaty rozrzedzające wydzielinę i działające przeciwobrzękowo), trwające nawet kilkanaście dni. Według Europejskich wytycznych na temat leczenia zapalenia śluzówki nosa i zatok przynosowych z 2012 roku (EPOS 2012) w niektórych przypadkach i okresach choroby mają zastosowanie substancje pochodzenia naturalnego – jako leczenie wspomagające. Należy do niego płukanie jam nosa fizjologicznym roztworem chlorku sodu lub odpowiednim roztworem wody morskiej oraz wykorzystanie roślinnych produktów leczniczych. Niniejszy artykuł szczegółowo omawia zastosowanie poszczególnych roślinnych produktów leczniczych i przedstawia dane literaturowe na temat ich skuteczności oraz tolerancji.
Źródło:
Pediatria i Medycyna Rodzinna; 2014, 10, 4; 427-439
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antibiotic therapy of acute upper respiratory tract infections and otitis media in adults
Autorzy:
Paź, Aleksandra
Arcimowicz, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1399732.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
antibiotics
drug resistance
acute rhinosinusitis
acute pharyngitis
acute laryngitis
acute otitis media
Opis:
An estimated 50% of antibiotic prescriptions may be unjustified in the outpatient setting. Viruses are responsible for most acute respiratory tract infections. The viral infections are often self-limiting and only symptomatic treatment remains effective. Bacteria are involved in a small percentage of infections etiology in this area. In the case of a justified or documented suspicion of a bacterial infection, antibiotic therapy may be indicated. Based on the Polish „Recommendations for the management of non-hospital respiratory infections 2016”, the indications, the rules of choice, the appropriate dosing schedules and the therapy duration, in the most frequent upper respiratory tract infections in adults, have been presented. Implementation of the presented recommendations regarding our Polish epidemiological situation, will significantly reduce the tendency to abuse antibiotics, and thus will limit the spread of drug-resistant microorganisms.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2018, 7, 1; 1-7
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Place of phytotherapy in the treatment of acute infections of upper respiratory tract and upper gastrointestinal tract
Autorzy:
Pietruszewska, Wioletta
Barańska, Magda
Wielgat, Jakub
Powiązania:
https://bibliotekanauki.pl/articles/1398294.pdf
Data publikacji:
2018
Wydawca:
Index Copernicus International
Tematy:
acute rhinosinusitis
acute pharyngitis
phytotherapy
acute infections of an upper respiratory tract and upper gastrointestinal tract
Opis:
Acute infections of the upper respiratory tract and upper gastrointestinal tract (mouth and throat) are still the most common reason for reporting to the general practitioner or ENT specialist. Despite the fact that the most common causative agent of these diseases is a virus, antibiotics are still flavored in about 60-80% of patients who report to the doctor. In consensuses such as EPOS, WHO reports and other local/ / national reports, there is a need to limit antibacterial treatment for and to replace it with symptomatic and anti-inflammatory drugs. In addition to intranasal steroids and mucocutaneous decongestants, supplementary treatment should be considered which resolves persistent symptoms. Plant preparations are used here. The growing role of rational phytotherapy is emphasized, especially due to the most frequent the etiological factor of these infections, i.e. viruses. Modern phytotherapy is a part of pharmacology, and all preparations based on plants meet the standards for of medicines and are subject to standard registration procedures. The article discusses the use and mechanism of action of selected herbs, among others: sorrel, elderberry, yarrow, and horsetail in the treatment of upper respiratory tract infections and upper gastrointestinal tract. The phytotherapy shows good efficacy and tolerance and can be used both in children and adults in recurrent infections of the upper respiratory tract. It is worth paying attention to the combined preparations, the components of which have the effects confirmed by randomized trials and long-term registration for use in treatment, both during the first signs of cold and its further duration, and supportive as support in chronic inflammation especially of the paranasal sinuses.
Źródło:
Polish Journal of Otolaryngology; 2018, 72, 4; 42-50
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of the effect of inflammatory changes and allergic reaction on TAS2R38 receptor expression in patients with chronic sinusitis (CRS)
Autorzy:
Piskadło-Zborowska, Karolina
Stachowiak, Małgorzata
Sarnowska, Elżbieta
Jowik, Rafał
Dżaman, Karolina
Powiązania:
https://bibliotekanauki.pl/articles/1397310.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
bitter taste receptor
chronic rhinosinusitis
TAS2R38 gene
TAS2R38 receptor
Opis:
Background: Chronic rhinosinusitis (CRS) is one of the most common health complaints affecting 15% of the world’s population. Recent reports confirm the participation of sensory organs in the defense process against pathogenic microorganisms. The bitter taste receptor TAS2R38 is described to play a role in the upper airway defense system. Purpose: The purpose of this study was to assess the function of the bitter taste receptor in correlation with the severity of CRS, sensory organ disorders and allergic reaction. Material and method: The study contained 100 patients undergoing nasal surgery, divided into two groups: CRS with and without nasal polyps. The control group consisted of patients undergoing septoplasty after excluding rhinosinusitis. Sinus mucosa samples obtained during surgery were used to assess TAS2R38 expression using immunohistochemistry. The IgE level was indicated from blood samples collected from patients. The Sniffin’ Sticks Test was performed. Results: CRS patients had higher expression of TAS2R38 receptor compared to controls (p = 0.0175). A statistically significantly higher TAS2R38 H-score in nasal mucosa was found among patients with a higher inflammation process in CT scan (p = 0.001), higher IgE level (p = 0,04) and an abnormal result of the Sniffin’ Sticks Test. Conclusions: Patients with CRS had significant TAS2R38 receptor overexpression correlating with the severity of inflammatory changes in CT scans, abnormal perception of smells and higher IgE level. A cumulative impact was found between the inflammatory changes, smell disfunction and the severity of subjective symptoms of CRS (according to EPOS) and the intensity of cell staining (index H-score).
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 5; 17-23
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tissue remodelling in chronic rhinosinusitis – review of literature
Autorzy:
Radajewski, Kamil
Wierzchowska, Małgorzata
Grzanka, Dariusz
Antosik, Paulina
Zdrenka, Marek
Burduk, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/1397806.pdf
Data publikacji:
2019
Wydawca:
Index Copernicus International
Tematy:
chronic rhinosinusitis
nasal polyps
tissue remodeling
Opis:
CRS is a process involving a number of adverse changes in the mucosa of the paranasal sinuses and nasal polyps, e.g. increased fibroblast proliferation, angiogenesis, increased formation of fibrous tissue (subepithelial fibrosis) and tissue destruction. There are biomarkers whose levels can be increased in chronic inflammation of the paranasal sinuses: peripheral blood eosinophilia, IgE immunoglobulin, cytokines – IL-4, IL-5, IL-13, IL-25, IL-33, periostin, P-glycoprotein, CXCL-12, CXCL-13, INF-Υ, TNFα, TGFβ1, albumins, eotaxin. These biomarkers are not pathognomonic for CRS. The concentration of biomarkers is also increased in bronchial asthma and atopic dermatitis. The TGFβ, in particular the β1 subunit, was identified as the main factor involved in the remodelling of tissue stroma. In conjunction with continuous improvement of tissue testing methods, it is advisable to search for new factors that will more accurately allow the assessment of tissue remodelling in the chronic processes of paranasal sinuses.
Źródło:
Polish Journal of Otolaryngology; 2019, 73, 5; 1-4
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Intranasal steroid therapy – EPOS 2020
Autorzy:
Rot, Piotr
Rapiejko, Piotr
Jurkiewicz, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/1397321.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
corticosteroids
EPOS 2020
rhinosinusitis
Opis:
Introduction: Due to their strong, multidirectional anti-inflammatory activity, intranasal glucocorticoids are the mainstay of treatment in rhinosinusitis, including acute rhinosinusitis, chronic rhinosinusitis, and chronic rhinosinusitis with nasal polyps, as well as allergic rhinitis. Owing to its high systemic safety and high anti-inflammatory efficacy, mometasone furoate – a new-generation intranasal glucocorticoid – was approved in 2019 as an over-the-counter (OTC) medication for Polish patients diagnosed with allergic rhinitis. Scientific societies and expert groups recommend the use of intranasal glucocorticoids in a much broader range of indications. In February 2020, an updated version of the European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS 2020) was published. Aim: This article discusses the role of nasal glucocorticoids in regimens used in the treatment of nasal sinusitis as published in EPOS 2020 with Polish country-specific realities being taken into account.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 3; 41-49
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
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