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    Wyświetlanie 1-11 z 11
    Tytuł:
    Expression of p16 in sporadic primary uveal melanoma.
    Autorzy:
    Lamperska, Katarzyna
    Mackiewicz, Krystyna
    Kaczmarek, Aldona
    Kwiatkowska, Eliza
    Starzycka, Maria
    Romanowska, Bożena
    Heizman, Janina
    Stachura, Jerzy
    Mackiewicz, Andrzej
    Powiązania:
    https://bibliotekanauki.pl/articles/1043765.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    sporadic primary uveal melanoma
    mutations
    p16 protein
    Opis:
    Expression of p16 protein, intragenic mutations of CDKN2A and hypermethylation of CDKN2A promoter region in 41 sporadic primary uveal melanomas were studied. There were 2 cases of spindle cell B histological type, 11 of A + B and 28 of mixed type. All melanomas infiltrated sclera but in 28 cases infiltration was superficial while in 13 profound. In 7 cases the tumor infiltrated the optic nerve. Expression of p16 was studied by immunohistochemistry and recorded by assessment of the proportion of positive tumor cells and staining intensity. Results were expressed as staining index (IRS). Intragenic mutations were studied by PCR-SSCP followed by sequencing, while hypermethylation of the promoter region by CpG methylation assay. In 15% of cases less than 10% of melanoma cells were p16 positive, in 70% of cases less than 50% of cells, while in 7% more than 80% of cells stained for p16 (mean IRS for all cases was 4.87 ± 2.43). In B type the IRS was 8.5 ± 0.7, in A + B type 6.0 ± 2.1 and in the mixed type 4.17 ± 2.43 (differences statistically significant). In melanomas profoundly infiltrating sclera mean IRS was 4.16, while in those infiltrating optic nerve 3.71 (statistically not significant). Analysis of the intragenic mutations revealed in two patients a GAC/GAT substitution in codon 84 - a silent mutation. No hypermethylation of the CpG island of the p16 promoter region was found. In conclusion, we found that the degree of p16 expression is related to the histological type of tumor but not to the histological indicators of tumor invasiveness and that intragenic mutations and promoter hypermethylation are not major mechanisms of p16 inactivation in sporadic uveal melanoma.
    Źródło:
    Acta Biochimica Polonica; 2002, 49, 2; 377-385
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Expression profiles of MGMT, p16, and APC genes in tumor and matching surgical margin from patients with oral squamous cell carcinoma
    Autorzy:
    Strzelczyk, Joanna
    Gołąbek, Karolina
    Krakowczyk, Łukasz
    Owczarek, Aleksander
    Powiązania:
    https://bibliotekanauki.pl/articles/1038771.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    HNSCC
    gene expression
    surgical margin
    MGMT
    p16
    APC
    Opis:
    The aim of the study was to assess the expression of MGMT, p16, and APC genes in tumors and matching surgical margin samples from 56 patients with primary OSCC. We also analyzed the association of the clinical variables with the expression of the studied genes. After RNA isolation and cDNA synthesis gene expression levels were assessed by quantitative reverse transcription (qRT)-PCR. Two-sided parametrical Student's t-test for independent groups with equal/unequal variances showed no statistically significant differences in genes' expression in tumor compared to margin samples. No association was found between the genes' expression and clinical parameters, except for MGMT, whose low expression was probably associated with smoking (0.87 vs 1.34, p=0.065). 'Field cancerization' is an area with genetically or epigenetically altered cells and at the same time a risk factor for cancer. Disturbances in gene expression could also be the source of damages leading to cancerization. In conclusion, it is important to mention that the field remaining after a surgery may pose an increased risk of cancer development. It may be suggested that the diagnosis and treatment of cancers should not be concentrated only on the tumor itself, but also on the cancer field effect. Therefore, further molecular analysis on surgical margins and additional research regarding their assessment are required.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 505-509
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Proliferation and apoptosis of human T cells during replicative senescence - a critical approach.
    Autorzy:
    Jaruga, Ewa
    Skierski, Janusz
    Radziszewska, Ewa
    Sikora, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1044352.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    senescence
    p16
    CD25
    apoptosis
    T cells
    proliferation
    CD8
    Opis:
    Normal human T lymphocytes growing in culture undergo replicative senescence. Previously, we have shown that in our conditions polyclonal T cells cease proliferation after about three weeks (Radziszewska et al., 1999, Cell Biol. Int. 23, 97-103). Now we present results of a more detailed analysis of in vitro growth as well as phenotypic changes of T cells. Cell cycle analysis showed that about 20% of cells were in the S phase untill the 17th day of culture (young cells). The highest number of mitotic cells (phase G2/M; 10%) was observed during the first week of culture. All not dividing senescent cells were stopped in the G1 phase (after the 30th day of culture). The sub-G1 fraction which represents apoptotic cells did not exceed 8% during the whole period until the 30th day of culture. During in vitro T-cell growth, a rather rapid selection to CD3+CD8+ cells occurs. In the presenescent (between the 17th and 30th day) and senescent populations the majority of cells (above 90%) were CD8 positive. We also have checked the expression of α-chain interleukin-2 (IL-2) receptor (CD25). In young and presenescent cells about one third of cells was CD25 positive, but only 15% in the pool of senescent cells. Immunoblotting analysis of p16 protein recognized previously as a marker of senescent T cells, showed its highest and transient expression in presenescent cells. A critical review of the polyclonal T cell replicative senescence model is presented.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 2; 293-300
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nanostructuring and Hardness Investigations of Thin Films by Scanning Force Microscopy
    Autorzy:
    Nowicki, M.
    Richter, A.
    Ries, R.
    Oszwałdowski, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1968828.pdf
    Data publikacji:
    1998-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    61.16.Ch
    68.35.-p
    Opis:
    The scanning force microscope was used to scratch thin films and to write nanoscale pattern on surfaces as well as to perform nanoindentation for hardness measurements. Different thin film materials such as C$\text{}_{60}$ films, diamond-like carbon, metals and semiconducting films have been investigated.
    Źródło:
    Acta Physica Polonica A; 1998, 93, 2; 437-441
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Lattice Parameter Relaxation during MBE of ZnTe/Cd$\text{}_{1-x}$Zn$\text{}_{x}$Te/Cd$\text{}_{0.5}$Zn$\text{}_{0.5}$Te Buffer Layers by RHLED and HRTEM
    Autorzy:
    Kret, S.
    Karczewski, G.
    Zakrzewski, A.
    Dłużewski, P.
    Dubon, A.
    Wojtowicz, T.
    Kossut, J.
    Delamarre, C.
    Laval, J. Y.
    Powiązania:
    https://bibliotekanauki.pl/articles/1933838.pdf
    Data publikacji:
    1995-10
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    61.16.Bg
    61.14.Hg
    68.35.-p
    Opis:
    The dynamics of the lattice relaxation processes were investigated using a reflection of a high energy electron diffraction analysis system during growth by molecular beam epitaxy of ZnTe/Cd$\text{}_{1-x}$Ζn$\text{}_{x}$Te/Cd$\text{}_{0.5}$Mn$\text{}_{0.5}$Te buffers on GaAs substrates. The variation of the lattice parameter recorded by the high energy electron diffraction during the growth was later confirmed by an analysis of high resolution transmission electron microscopy images. We report also on an observation of oscillations of the lattice parameter during the deposition of several first layers of ZnTe on CdTe.
    Źródło:
    Acta Physica Polonica A; 1995, 88, 4; 795-798
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Materials Patterning and Characterisation at the Nanometre Scale Using Focused MeV Ion Beams: Present Achievements and Future Prospects
    Autorzy:
    Grime, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/1628030.pdf
    Data publikacji:
    2009-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    81.16.Nd
    41.75.Ak
    41.85.-p
    Opis:
    A key phenomenon in the interaction of MeV ions and solids is that the energy transferred from the primary ions to the target electrons is high compared with atomic and molecular binding energies, but low compared with the ion energy. This means that there is a high probability of modifying the chemical properties of the material (for patterning) or of inducing the emission of electromagnetic radiation (for analysis), yet the path of particle is changed by a negligible amount, which means that focused beams remain sharp even after penetrating long depths into the material. Developments in focusing MeV ions in recent years have pushed the useable beam diameters into the sub-micrometre region, which means that nuclear microbeams are poised to make an impact in both direct write fabrication and micro-analysis at length scales of interest in nanotechnology or microbiology. This paper reviews the science and technology underlying the use of nuclear microbeams (ion solid interactions, focusing systems) and reports on the present status and trends of applications in sub-micron scale applications.
    Źródło:
    Acta Physica Polonica A; 2009, 115, 2; 467-472
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Historia polskich nazw roślin występujących w poradniku P. Krescencjusza
    The History of Polish Names of Plants Appearing in P. Crescentiuss Manual
    Autorzy:
    Kamper-Warejko, Joanna
    Powiązania:
    https://bibliotekanauki.pl/articles/568062.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Mikołaja Kopernika w Toruniu. Wydawnictwo UMK
    Tematy:
    History of the Polish language
    the Polish language of the 16th century
    historical fitonyms
    Polish vocabulary concerning plant in the reference manual by P. Crescentius
    Opis:
    The material presented in the article comes from the second edition (1571) of the Polish translation of the reference manual by Peturs de Crescentius. To the extent posiible, it was identified and confronted with the historical botanic vocabulary. The aim of the analysis is to trace the mechanism of naming plants described in the manual and to research how the fitonyms functioned in the historical Polish language at that time as well as in the subsequent centuries. It has been noticed that most names of the pre-Slavic and pre-Indo_European origin fossilize and do not alter throughout the history of the Polish language. Words of younger origin frequently illustrate the phonetic changes which took place in order to simplify articulation. Examples of secondary nominalization, taken from the text, other hand, they manifest the use of word-formative mechanisms. Some of the names have disappeared, while others have survived and appear in the botanic nomenclature of the 18th century (in K. Kluk). Moreover, the material analyzed shows the creative input of the translator of the work, who evinced good intuition in choosing the terms which have stood the test of time (e.g. faseol, lubczyk, por).
    Źródło:
    Linguistica Copernicana; 2014, 11; 143-158
    2080-1068
    2391-7768
    Pojawia się w:
    Linguistica Copernicana
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Dwie średniowieczne tradycje lubelskie oraz ich wpływ na poczucie tożsamości lokalnej wspólnoty (XIII? – początek XVII w.)
    Autorzy:
    Michalski, Wojciech
    Powiązania:
    https://bibliotekanauki.pl/articles/607565.pdf
    Data publikacji:
    2017
    Wydawca:
    Uniwersytet Marii Curie-Skłodowskiej. Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
    Tematy:
    medieval local traditions
    Lublin – history, 13th–14th century
    Lublin community, 13th–16th century – sense of identity
    Lublin community – historical consciousness
    traditions about Tatar siege of Lublin castle in the winter of 1340/134
    1 St. Michael’s p
    Lublin – średniowieczne tradycje lokalne
    Lublin – historia, XIII–XIV w.
    Lublina – świadomość historyczna
    społeczność Lublina, XIII–XVII w. – poczucie tożsamości
    tradycje o oblężeniu zamku lubelskiego przez Tatarów zimą 1340/1341 r.
    Fara św. Michała w.
    Opis:
    The article presents the medieval accounts of the two short stories about the past of Lublin, concerning the siege of its castle by Tatars in the winter of 1340/1341 and the apparition of St. Michael to prince Leszek Czarny and the ruler’s subsequent victory over pagan Jatvings (1282). Following the traces of the familiarity of these narratives in the town up to the turn of the 16th century, it is argued that they were well recognized local traditions. They conveyed ideas of particular importance and attractiveness to theLublin community and provided a distinct way of perceiving of the important elements of townscape. Thus the stories about legendary history ofLublin influenced the sense of identity of theLublin community in several significant ways.
    Artykuł przedstawia średniowieczne wersje dwóch opowieści o przeszłości Lublina, dotyczące oblężenia miejscowego zamku przez Tatarów na przełomie 1340 i 1341 r. oraz ukazania się świętego Michała księciu Leszkowi Czarnemu i zwycięstwa władcy nad Jaćwingami w 1282 r. Przyglądając się śladom znajomości tych narracji w mieście nad Bystrzycą do początku XVII w., autor dowodzi, że były to wówczas dobrze znane tradycje lokalne. Wyrażały one idee szczególnie ważne i atrakcyjne dla społeczności Lublina. Za ich sprawą członkowie miejscowej wspólnoty postrzegali ważne elementy miejskiej przestrzeni w swoisty dla swej grupy sposób. Można zatem dostrzec, że opowieści z kręgu legendarnych dziejów Lublina oddziaływały na poczucie tożsamości członków społeczności Lublina w kilku ważnych aspektach.
    Źródło:
    Annales Universitatis Mariae Curie-Skłodowska, sectio F – Historia; 2017, 72
    0239-4251
    Pojawia się w:
    Annales Universitatis Mariae Curie-Skłodowska, sectio F – Historia
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-11 z 11

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