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Wyszukujesz frazę "oleuropein" wg kryterium: Temat

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    Wyświetlanie 1-2 z 2
    Tytuł:
    Determination of oleuropein in herbal preparation and Olea europaea L. extracts by HPLC
    Autorzy:
    Szymański, M.
    Witkowska-Banaszczak, E.
    Matławska, I.
    Szymański, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/346909.pdf
    Data publikacji:
    2013
    Wydawca:
    Politechnika Bydgoska im. Jana i Jędrzeja Śniadeckich. Wydział Technologii i Inżynierii Chemicznej
    Tematy:
    oleuropein
    Olea europaea L.
    herbal products
    high performance liquid chromatography
    Opis:
    Oleuropein is a secoiridoide monoterpene. It is found primarily in all parts of the Olea europaea L. tree, mostly in its unripe fruit and leaves. It has a number of beneficial effects on the human body, being readily absorbed from the gastrointestinal tract due to its hydrophilic properties. The paper presents a simple, rapid and precise method for the assay of oleuropein in herbal formulations and the European Olive leaf extract. Chromatographic separation was performed using a C-18 column with an acetonitrile/water 20/80% vol. mixture as the mobile phase. The method has a wide range of linearity between 0.05 and 1.5 mg/mL, very good repeatability of retention time, and accuracies between 95.8 and 103.3%. Its limit of detection is 0.04 mg/mL. The developed method was tested on two herbal formulations which are commercially available in Poland.
    Źródło:
    Ars Separatoria Acta; 2012-2013, 9/10; 55-63
    1731-6340
    Pojawia się w:
    Ars Separatoria Acta
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of olive leaf polyphenols against H2O2 toxicity in insulin secreting β-cells
    Autorzy:
    Cumaoğlu, Ahmet
    Rackova, Lucia
    Stefek, Milan
    Kartal, Murat
    Maechler, Pierre
    Karasu, Çimen
    Powiązania:
    https://bibliotekanauki.pl/articles/1039946.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    olive
    glucose
    insulin
    hydrogen peroxide
    polyphenol
    apoptosis
    β-cells
    oxidative stress
    oleuropein
    Opis:
    In pancreatic β-cells, although H2O2 is a metabolic signal for glucose stimulated insulin secretion, it may induce injury in the presence of increased oxidative stress (OS) as in the case of diabetic chronic hyperglycemia. Olea europea L. (olive) leaves contain polyphenolic compounds that may protect insulin-secreting cells against OS. The major polyphenolic compound in ethanolic olive leaf extract (OLE) is oleuropein (about 20 %), thus we compared the effects of OLE with the effects of standard oleuropein on INS-1 cells. The cells were incubated with increasing concentrations of OLE or oleuropein for 24 h followed by exposure to H2O2 (0.035 mM) for 45 min. H2O2 alone resulted in a significantly decreased viability (MTT assay), depressed glucose-stimulated insulin secretion, increased apoptotic and necrotic cell death (AO/EB staining), inhibited glutathione peroxidase activity (GPx) and stimulated catalase activity that were associated with increased intracellular generation of reactive oxygen species (ROS) (fluorescence DCF). OLE and oleuropein partly improved the viability, attenuated necrotic and apoptotic death, inhibited the ROS generation and improved insulin secretion in H2O2-exposed cells. The effects of oleuropein on insulin secretion were more pronounced than those of OLE, while OLE exerted a stronger anti-cytotoxic effect than oleuropein. Unlike OLE, oleuropein had no significant preserving effect on GPx; however, both compounds stimulated the activity of catalase in H2O2-exposed cells. These findings indicate different modulatory roles of polyphenolic constituents of olive leaves on redox homeostasis that may have a role in the maintenance of β-cell physiology against OS.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 1; 45-50
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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