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Wyszukujesz frazę "neurotoxicity" wg kryterium: Temat

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    Wyświetlanie 1-10 z 10
    Tytuł:
    Pretreatment with diallylsulphide modulates mercury-induced neurotoxicity in male rats
    Autorzy:
    Ansar, Sabah
    Powiązania:
    https://bibliotekanauki.pl/articles/1039013.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    diallylsulphide
    metal toxicity
    neurotoxicity
    antioxidants
    Opis:
    Many studies have reported on the toxicity and related oxidative stress of mercury. Antioxidants play an important role in counteracting metal-induced neurotoxicity under in vivo conditions. In this study, the effect of diallylsulphide (DAS) was evaluated on mercuric chloride induced activities of catalase, superoxide dismutase, glutathione peroxidase and glutathione content in brains of rats. Pretreatment of rats with DAS in the Hg-treated group also inhibited an increase in lipid peroxidation and elevated acetyl cholinesterase and glutathione content. Activities of antioxidant enzymes were also restored concomitantly when compared to the control rats after DAS administration. DAS also caused a decrease in tumor necrosis factor-α level which was higher in HgCl2-treated group. The results indicate that DAS augments antioxidant defense with anti-inflammatory response against HgCl2-induced neurotoxicity. The increased level of antioxidant enzymes enhances the antioxidant potential of the organ to reduce oxidative stress.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 599-603
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effect of amyloid beta peptide on poly(ADP-ribose) polymerase activity in adult and aged rat hippocampus.
    Autorzy:
    Strosznajder, Joanna
    Jęśko, Henryk
    Strosznajder, Robert
    Powiązania:
    https://bibliotekanauki.pl/articles/1044342.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    aging
    amyloid
    poly(ADP-ribose) polymerase
    hippocampus
    neurotoxicity
    Opis:
    It is suggested that the fibrillar amyloid beta peptide (Aβ) in brain plays a direct role in neurodegeneration in Alzheimer's disease, probably through activation of reactive oxygen species formation. Free radicals and numerous neurotoxins elicit DNA damage that subsequently activates poly(ADP-ribose) polymerase (PARP, EC 2.4.2.30). In this study the effect of neurotoxic fragment (25-35) of full length Aβ peptide on PARP activity in adult and aged rat hippocampus was investigated. In adult (4 month old) rat hippocampus the Aβ 25-35 peptide significantly enhanced PARP activity by about 80% but had no effect on PARP activity in cerebral cortex and in hippocampus from aged (24-27 month old) rats. The effect of Aβ peptide was reduced by half by the nitric oxide synthase inhibitor N-nitro-L-arginine. Stimulation of glutamate receptor(s) itself enhanced PARP activity by about 80% in adult hippocampus. However, Aβ 25-35 did not exert any additional stimulatory effect. These results indicate that Aβ, through NO and probably other free radicals, induces activation of DNA bound PARP activity exclusively in adult but not in aged hippocampus.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 3; 847-854
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Severe vascular and neurological complications after hematopoietic stem cell transplantation with reduced intensity conditioning
    Autorzy:
    Czyżewski, Krzysztof
    Nierychlewska, Paulina
    Richert-Przygońska, Monika
    Cieściński, Jakub
    Styczyński, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1035762.pdf
    Data publikacji:
    2019
    Wydawca:
    Medical Education
    Tematy:
    ALLO-HSCT
    PRES
    fludarabine
    neurotoxicity
    reduced intensity conditioning
    Opis:
    It is well established that the benefit of myeloablative ALLO-HSCT can be associated with a potential high risk of procedure-related toxicity. The objective of this report is the analysis of complications in a 17-year-old girl with AML previously treated for medulloblastoma and myelodysplastic syndrome. Thiotepa, fludarabine, treosulfan and thymoglobuline were used in conditioning regimen. During conditioning neurological complications have occurred. MRI and CT scan results revealed the coexistence of PRES with the left internal carotid artery thrombosis. The effect of fludarabine on endothelial cells could possibly contribute to irreversible CNS damage and death in presented case.
    Źródło:
    OncoReview; 2019, 9, 1; 27-30
    2450-6125
    Pojawia się w:
    OncoReview
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Convulsions and hypoglycemia due to tetramethyl succinonitrile intoxication in the polyvinyl chloride (PVC) industry: A 4-year follow-up
    Autorzy:
    Enssli, Angela
    Koller, Michael
    Powiązania:
    https://bibliotekanauki.pl/articles/2178819.pdf
    Data publikacji:
    2014-05-17
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    tetramethyl succinonitrile
    neurotoxicity
    convulsion
    Epilepsy
    occupational exposure
    hypoglycemia
    Opis:
    Objectives: Exposure and clinical data concerning cases of toxic convulsions and hypoglycemia due to tetramethyl succinonitrile (TMSN) exposure are reported. Material and Methods: Forty-four workers exposed to TMSN in the PVC production plant participated in occupational health medical check-ups including medical history, clinical examination and clinical chemistry. A 4-year follow-up was performed. To evaluate occupational exposure, measurements of TMSN in the ambient air as well as personal air sampling were conducted. Results: Four workers suffered from convulsions with reversible pathologic EEG and 16 other persons were hypoglycemic. Other frequent symptoms included headaches, dizziness and unpleasant taste sensations. TMSN levels had been clearly above the Swiss occupational exposure limit value (MAK). Occupational hygiene interventions resulted in a reduction of the TMSN concentration below the MAK value. TMSN related symptoms have not been observed anymore in the 4-year follow-up. Conclusion: TMSN is a convulsive substance which in humans has also a hypoglycemic effect.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2014, 27, 2; 188-195
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Molecular mechanisms initiating amyloid β-fibril formation in Alzheimers disease
    Autorzy:
    Kirkitadze, Marina
    Kowalska, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1041422.pdf
    Data publikacji:
    2005
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    protein aggregation
    fibrillogenesis
    Alzheimer's disease
    neurotoxicity
    amyloid-β
    APP mutations
    Opis:
    The deposition of aggregated amyloid β-protein (Aβ) in the human brain is a major lesion in Alzheimer' disease (AD). The process of Aβ fibril formation is associated with a cascade of neuropathogenic events that induces brain neurodegeneration leading to the cognitive and behavioral decline characteristic of AD. Although a detailed knowledge of Aβ assembly is crucial for the development of new therapeutic approaches, our understanding of the molecular mechanisms underlying the initiation of Aβ fibril formation remains very incomplete. The genetic defects responsible for familial AD influence fibrillogenesis. In a majority of familial cases determined by amyloid precursor protein (APP) and presenilin (PS) mutations, a significant overproduction of Aβ and an increase in the Aβ42/Aβ40 ratio are observed. Recently, it was shown that the two main alloforms of Aβ have distinct biological activity and behaviour at the earliest stage of assembly. In vitro studies demonstrated that Aβ42 monomers, but not Aβ40, form initial and minimal structures (pentamer/hexamer units called paranuclei) that can oligomerize to larger forms. It is now apparent that Aβ oligomers and protofibrils are more neurotoxic than mature Aβ fibrils or amyloid plaques. The neurotoxicity of the prefibrillar aggregates appears to result from their ability to impair fundamental cellular processes by interacting with the cellular membrane, causing oxidative stress and increasing free Ca^(2+)that eventually lead to apoptotic cell death.
    Źródło:
    Acta Biochimica Polonica; 2005, 52, 2; 417-423
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Neurotoxicity of cyanobacterial toxins
    Autorzy:
    Florczyk, M.
    Łakomiak, A.
    Woźny, M.
    Brzuzan, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/363222.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Warmińsko-Mazurski w Olsztynie
    Tematy:
    blue-green algae
    cyanotoxins
    drug
    medicine
    microcystin
    neurotoxicity
    sinice
    cyjanotoksyny
    lek
    mikrocystyna
    neurotoksyczność
    Opis:
    Eutrophication of marine and fresh waters can lead to excessive development of cyanobacterial blooms, which may contain strains that produce toxins. These toxins are secondary metabolites which can accumulate in the food chain and contaminate drinking water, thus posing a potential threat to the health of humans and aquatic organisms. These toxins include a variety of compounds with different mechanisms; this review focuses on the neurotoxicity of microcystin and other cyanotoxins. Although the hepatotoxic action of microcystins is commonly known, its neurotoxic effects have also been described, e.g. oxidative stress, cytoskeletal changes and changes in protein phosphatase activity. These effects have been partially explained by the discovery in the blood brain barrier of the same membrane transporters involved in microcystins hepatotoxic mechanisms. Additionally, this paper reviews other cyanotoxins that are known or suspected to target cholinergic synapses and voltage gated channels, including anatoxin a, anatoxin a(s), antillatoxins, cylindrospermopsin, homoanatoxin a, jamaicamide, kalkitoxin and saxitoxins. The neurotoxic and cytotoxic effects of the cyanotoxins discussed here are of particular interest because of their pharmacological potential. This review also discusses the potential of these compounds to serve as drugs for cancer and central nervous system failure.
    Źródło:
    Environmental Biotechnology; 2014, 10, 1; 26-43
    1734-4964
    Pojawia się w:
    Environmental Biotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of 17-beta estradiol and estriol on NMDA-induced toxicity and apoptosis in primary cultures of rat cortical neurons
    Autorzy:
    Kajta, M.
    Budziszewska, B.
    Marszal, M.
    Lason, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/70785.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    cortical neuron
    oestriol
    oestriadol-17beta
    estrogen
    toxicity
    estrogen receptor
    neurotoxicity
    apoptosis
    hypoglycemia
    rat
    Źródło:
    Journal of Physiology and Pharmacology; 2001, 52, 3
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The role of nitric oxide in paraquat-induced oxidative stress in rat striatum
    Autorzy:
    Djukic, M
    Jovanovic, M.C.
    Ninkovic, M.
    Vasiljevic, I.
    Jovanovic, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/49779.pdf
    Data publikacji:
    2007
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    Wistar rat
    brain
    nitric oxide
    paraquat
    oxidative stress
    pesticide
    herbicide
    neurotoxicity
    exposure
    rat
    Opis:
    The role of nitric oxide (NO) in paraquat (PQ)-induced neurotoxicity is still not fully understood. In this study we used NG-nitro-L-arginine methyl ester (L-NAME), a non-selective nitric oxide synthase (NOS) inhibitor, in order to examine the effects of NO, reactive oxygen species (ROS) generation and lipid peroxidation (LPO) development during PQ-mediated neurotoxicity. Oxidative stress development in the striatum of Wistar rats intrastriatally (i.s.) poisoned with PQ (and in some cases pre-treated with L-NAME) was investigated by measuring superoxide anion (O2 •ˉ), malondialdehyde (MDA) and nitrate (NO3ˉ), 30 min, 24 hours and 7 days after treatment. L-NAME pretreatment provided the possibility to distinguish the role of ROS from reactive nitrogen species (RNS) in oxidative stress development induced by PQ. Our results confi rm the involvement of NO in PQ-mediated neurotoxicity and reduced LPO by L-NAME pretreatment implying that the latter has a protective role.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2007, 14, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of neurotoxicity of repeated dermal application of chlorpyrifos on hippocampus of adult mice
    Autorzy:
    Mitra, N K
    Siong, H.H.
    Nadarajah, V.D.
    Powiązania:
    https://bibliotekanauki.pl/articles/51858.pdf
    Data publikacji:
    2008
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    histomorphometry
    adult mouse
    pesticide
    mouse
    repeated exposure
    mice
    dermal toxicity
    chlorpyrifos
    neurotoxicity
    hippocampus
    cholinesterase inhibition
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2008, 15, 2
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Przemijający deficyt neurologiczny spowodowany neurotoksycznym działaniem środka kontrastowego użytego do zabiegu koronarografii
    Transient neurological deficit due to neurotoxicity of contrast medium used for coronary angiography
    Autorzy:
    Wilczewska, Renata
    Kułakowska, Alina
    Korneluk-Sadzyńska, Alicja
    Borowik, Helena
    Drozdowski, Wiesław
    Powiązania:
    https://bibliotekanauki.pl/articles/1058124.pdf
    Data publikacji:
    2010
    Wydawca:
    Medical Communications
    Tematy:
    complication
    contrast medium
    coronary angiography
    neurotoxicity
    transient neurological deficit
    koronarografia
    powikłanie
    środek kontrastowy
    neurotoksyczność
    przemijający deficyt neurologiczny
    Opis:
    Coronary angiography is an invasive procedure and may lead to complications. The most common of them are: myocardial infarction, embolism (e.g. cerebral embolism), dysrhythmia and acute circulatory insufficiency. Damage to the artery and subsequent major bleeding or thrombosis, vasovagal reaction and allergic reactions may also occur. Neurological deficits caused by contrast medium neurotoxicity are very rare complications of percutaneous coronary interventions. Contrast medium infiltrates blood-brain barrier and produces transient disturbances of neural membranes function. The neurotoxicity depends on its ionic properties, osmolality and solubility. Contrast medium neurotoxicity usually concerns occipital lobes and transient cortical blindness is its most common clinical manifestation. Transient pyramidal deficits due to contrast medium neurotoxicity are very rarely observed. The authors present a case of 70-yearold woman who developed left-sided hemiparesis and conjugate deviation of the eyes to the right after coronary angiography with subsequent right coronary artery angioplasty and stenting. Computed tomography (CT) of the brain performed just after occurrence of the neurological deficit revealed hyperintensive areas in sulci of the cerebral convexities and in the right frontal lobe. Control brain CT done after 24 hours did not show hyperintensive areas mentioned above. All symptoms of neurological deficit withdrew during 72 hours. Neurotoxicity of contrast medium seems to be responsible for occurrence of neurological deficit symptoms in a presented case.
    Koronarografia jest badaniem inwazyjnym i niesie ze sobą ryzyko wystąpienia powikłań. Najczęstszymi z nich są: zawały serca, incydenty zatorowe (w tym zatory tętnic mózgowych), zaburzenia rytmu serca i ostra niewydolność krążenia. Zdarzają się także uszkodzenia tętnicy i miejscowe krwawienia, reakcje naczyniowo-błędne i odczyny alergiczne. Deficyty neurologiczne spowodowane neurotoksycznym działaniem środka kontrastowego są bardzo rzadkim powikłaniem przezskórnych interwencji wieńcowych. Kontrast przenika przez barierę krew-mózg i powoduje przejściowe zaburzenia funkcji błon neuronalnych. Neurotoksyczne działanie środka kontrastowego zależy od jego właściwości jonowych, osmolalności i rozpuszczalności. Neurotoksyczność kontrastu dotyczy zazwyczaj płatów potylicznych, a jej najczęstszą manifestacją kliniczną jest przemijająca ślepota korowa. Przejściowe deficyty piramidowe wywołane działaniem środka kontrastowego są bardzo rzadko obserwowane. Autorzy przedstawiają przypadek 70-letniej kobiety, u której po zabiegu koronarografii oraz angioplastyki i stentowania prawej tętnicy wieńcowej wystąpił deficyt neurologiczny pod postacią niedowładu połowiczego lewostronnego oraz przymusowego skierowania gałek ocznych w stronę prawą. Wykonana bezpośrednio po wystąpieniu objawów klinicznych tomografia komputerowa (TK) mózgu ujawniła obecność hiperintensywnych ognisk w bruzdach mózgowych na sklepistości półkul mózgu oraz w prawym płacie czołowym. Kontrolna TK wykonana po upływie 24 godzin nie uwidoczniła wspomnianych ognisk. Objawy neurologiczne całkowicie wycofały się w ciągu 72 godzin od zachorowania. Wydaje się, iż działanie neurotoksyczne środka kontrastowego jest odpowiedzialne za objawy deficytu neurologicznego, które wystąpiły w prezentowanym przypadku.
    Źródło:
    Aktualności Neurologiczne; 2010, 10, 3; 172-175
    1641-9227
    2451-0696
    Pojawia się w:
    Aktualności Neurologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-10 z 10

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