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Wyświetlanie 1-15 z 19
Tytuł:
Novel strategies for aminoglycoside antibiotic delivery in skeletal tissues - a review
Autorzy:
Posadowska, U.
Pamuła, E.
Powiązania:
https://bibliotekanauki.pl/articles/285107.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
aliphatic polyesters
biopolymers
gentamicin administration
microparticles
osteomyelitis
Opis:
This paper reviews recent advances concerning antibiotic-loaded microparticles application in osteomyelitis treatment. We discuss different methods utilized for microparticles' preparation, i.e. double emulsification, simple emulsification and spray drying. Materials comprised of sphere-shaped matrices are also presented. We point out that the most commonly used microsphere-building components are biodegrad¬able aliphatic polyesters such as poly(lactide-co-glicolide) PLGA, poly(sebacic-ricinoleic-ester-anhydride) P(SA-RA) and poly(lactic-co-hydroxymethyl glycolic acid) PLHMGA. Biopolymers like gelatin, starch or chitosan are also applied as antibiotic carriers. Relationship between preparation method, type of material and its crosslinking degree, microparticles' immobilization steps and the amount of loaded antibiotic are reported as the main factors controlling release rate of drugs in osteomyelitis treatment. And finally, several approaches to produce injectable formulations as well as implantable three dimensional scaffolds with the use of microparticles are described. All in all, this proves that antibiotic-loaded microspheres are a versatile form of biomaterials in osteomyelitis therapy.
Źródło:
Engineering of Biomaterials; 2012, 15, 114; 3-7
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of hemocompatibility of materials with arterial blood flow by platelet functional tests
Autorzy:
Sanak, M.
Jakieła, B.
Węgrzyn, W.
Powiązania:
https://bibliotekanauki.pl/articles/200067.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
hemocompatibility tests
blood shear stress
platelet microparticles
Opis:
Hemocompatibility test of medical materials aims to detect adverse interaction between artificial surface and blood, which can activate or destruct blood components. In arterial flow conditions, due to a high shear stress, platelet is the cell critical for the hemocompatibility compliance. A classical instrumentation for the dynamic test of hemocompatibility involves a flow chamber with a contact surface between blood stream and tested plate. In the current study we investigated a simplified model of the whole blood shear stress, based on a cone and plate rotational viscometer. Several indices of platelet activation were analyzed, including platelet- and granulocyte-platelet aggregates, platelet activation markers and platelet-derived microparticles. This model allowed to estimate platelet destruction, however no adhesion could be measured directly. In following tests of several polymer and metallic layer coated materials, the test revealed comparable performance to more laborious hemocompatibility experiments. We suggest, that thrombogenic potential of platelet-derived microparticles, which can be accurately measured in blood plasma, offers very useful estimate of hemocompatibility. Moreover, this parameter has already been validated in clinics and could be used for monitoring of implanted cardiovascular materials.
Źródło:
Bulletin of the Polish Academy of Sciences. Technical Sciences; 2010, 58, 2; 317-322
0239-7528
Pojawia się w:
Bulletin of the Polish Academy of Sciences. Technical Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sedymentacja mikrocząstek osadów wodociągowych
Sedimentation of microparticles from water supply system
Autorzy:
Hofman, A.
Dziubiński, M.
Sowiński, J.
Powiązania:
https://bibliotekanauki.pl/articles/2073144.pdf
Data publikacji:
2015
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
sedymentacja
mikrocząstki
wodociągi
sedimentation
microparticles
water supply system
Opis:
Przedstawiono wyniki badań i obliczeń prędkości sedymentacji zawiesin mikrocząstek osadów pochodzących z płukania systemu wodociągowego. Wykonano również badania wielkości mikro-cząstek osadów wodociągowych i rozkładu ich średnic. Eksperymentalnie określono prędkość sedymentacji zawiesin mikrocząstek oraz porównano ją z obliczoną wg wybranych modeli sedymentacji. Stwierdzono znaczne rozbieżności. Przedyskutowano wpływ średniej średnicy arytmetycznej i geometrycznej mikro-cząstek na obliczeniową prędkość sedymentacji mikrocząstek.
The paper presents the results of research and calculations of sedimentation velocity of microparticle suspensions from a flushing water supply system. Investigations of microparticle diameters and distribution of their size were also carried out. Determined experimentally values of sedimentation velocities were compared with selected sedimentation models. The significant discrepancies between the experimental and calculated values of sedimentation velocities of micro-particles suspensions were found. The influence of arithmetic and geo-metric average diameters of microparticle on the description of experimental data concerning sedimentation velocities of microparticles are discussed.
Źródło:
Inżynieria i Aparatura Chemiczna; 2015, 6; 326--327
0368-0827
Pojawia się w:
Inżynieria i Aparatura Chemiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polysiloxane microcapsules, microspheres and their derivatives
Polisiloksanowe mikrokapsułki, mikrosfery i ich pochodne
Autorzy:
Slomkowski, S.
Fortuniak, W.
Chojnowski, J.
Pospiech, P.
Mizerska, U.
Powiązania:
https://bibliotekanauki.pl/articles/945786.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
Tematy:
polysiloxane microspheres
polysiloxane microcapsules
functionalized microparticles
synthesis of polysiloxane microparticles
carriers of catalysts
phase change materials
preceramic materials
sfunkcjonalizowane mikrocząsteczki
Opis:
The paper summarizes progress in synthesis of polysiloxane microspheres, as well as in preparation of their functional and ceramic derivatives. Synthesis of microcapsules with polysiloxane shells is also discussed. Structure and most important properties of the microparticles are analyzed. Presented routes used for formulation of microspheres include preparation the particles by a sol-gel process from the functional (e.g., containing vinyl groups alkoxysilanes) and by cross-linking of polyhydrosiloxanes with low molar mass or oligomeric divinyl compounds (in many instances also polysiloxanes). The minireview describes also synthesis of polysiloxanes from polyhydrosiloxanes and divinyl compounds in a process involving hydrolysis of ≡SiH groups to ≡SiOH silanols and their dehydrocondensation, carried out in dispersed systems. Synthesis of modified polysiloxane microspheres yielding the particles with controlled hydrophobic/hydrophilic balance [presence of the hydrophobic (CH3)3Si– or ≡SiOCH(CH3)2 and hydrophilic siloxane groups] is discussed. Preparation of the functionalized particles with epoxy, amine, and vinyl groups is presented. The paper describes modification of the routes of synthesis of the polysiloxane particles was yielding hybrid particles with the core-shell structure, in which polysiloxanes constitute the particles' cores or shells. In the latter case, the particles had the structure of polysiloxane microcapsules containing encapsulated inorganic or organic material. Preparation of composed microspheres, which in addition to polysiloxane contain a significant fraction of organic material is described. The paper depicts polysiloxane microspheres as an attractive preceramic material. Selected applications of polysiloxane based particles as carriers of catalysts, optical diffusers and phase-change microspheres are discussed.
Przedstawiono rozwój syntezy polisiloksanowych mikrosfer i ich funkcjonalnych oraz ceramicznych pochodnych. Omówiono syntezę mikrokapsułek z polisiloksanową otoczką, analizowano strukturę i najważniejsze ich właściwości. Opisano metody wykorzystane do formowania mikrosfer, obejmujące wytwarzanie mikrosfer w procesach zol-żel z komponentów funkcjonalnych (np. alkoksysilanów zawierających grupy winylowe), sieciowania polihydrosilanów oraz o małej masie molowej lub oligomerycznych substratów diwinylowych (w większości wypadków także polisiloksanów). Poniższy mini przegląd literatury dotyczy także syntezy polisiloksanów z polihydrosiloksanów i komponentów diwinylowych w procesie hydrolizy grup ≡SiH do ≡SiOH i następnej ich dehydrokondensacji w dyspersji wodnej. Syntetyzowanie modyfikowanych mikrosfer polisiloksanowych umożliwia otrzymanie cząsteczek o kontrolowanym bilansie hydrofilowo-hydrofobowym [obecność grup hydrofobowych (CH3)3Si– lub ≡SiOCH(CH3)2 i hydrofilowych grup siloksanowych]. Omówiono wytwarzanie cząsteczek zawierających epoksydowe, aminowe i winylowe grupy funkcyjne. Opisano modyfikacje metod syntezy polisiloksanowych cząsteczek, prowadzące do cząsteczek hybrydowych o strukturze rdzeń-otoczka, w których polisiloksany tworzą otoczkę lub rdzeń, a także syntezę polisiloksanowych mikrokapsułek zawierających enkapsulowany organiczny bądź nieorganiczny materiał. W artykule przedstawiono polisiloksanowe mikrosfery jako atrakcyjny preceramiczny materiał o potencjalnym zastosowaniu w charakterze nośników katalizatorów, dyfuzorów optycznych i zmiennofazowych mikrosfer.
Źródło:
Polimery; 2017, 62, 7-8; 499-508
0032-2725
Pojawia się w:
Polimery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of microparticles in initiating the electric breakdown in high–voltage vacuum insulation systems
Autorzy:
Opydo, W.
Opydo, D.
Bieliński, W.
Powiązania:
https://bibliotekanauki.pl/articles/97674.pdf
Data publikacji:
2016
Wydawca:
Politechnika Poznańska. Wydawnictwo Politechniki Poznańskiej
Tematy:
high–voltage vacuum insulation systems
metallic microparticles
electric breakdown
Opis:
The paper presents the hypotheses of initiating mechanisms of the electric breakdown in vacuum insulation systems caused by small material granules, i.e. the microparticles. The microparticles detached from the parent electrode have an electric charge and move in the inter–electrode area due to the electric field. The role of a microparticle in initiating the breakdown in a vacuum insulation system depends to a considerable extent on the microparticle energy at the moment of its impact against the opposite electrode, i.e. on its velocity at the impact time. The paper presents calculation of the microparticle velocity values at the moment of the impact against the opposite electrode under the conditions existing in practice in the vacuum insulation systems. It was assumed for purposes of the calculation that the microparticles are spherical and made of copper, aluminum or iron, and are subjected to constant electric field. Minimum values of the microparticle velocity necessary to cause plastic deformation of the electrode surface in result of the impact are determined. (The calculations have been carried out with the computer program developed in C# language on the Visual Studio 2013 environment.)
Źródło:
Computer Applications in Electrical Engineering; 2016, 14; 177-186
1508-4248
Pojawia się w:
Computer Applications in Electrical Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Early response of selected haemostatic and haematological parameters to physical activity in young women - the potential impact of oral contraceptives
Autorzy:
Jastrzębska, Maria
Żyżniewska-Banaszak, Ewelina
Nawrot, Małgorzata
Marcinowska, Zuzanna
Siennicka, Aldona
Chełstowski, Kornel
Stachowiak, Paweł
Kordaczuk, Michał
Przybycień, Krzysztof
Clark, Jeremy
Powiązania:
https://bibliotekanauki.pl/articles/972632.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
exercise
contraception
haemostasis
platelet function tests
cell derived microparticles
Opis:
Introduction and objective. Exercise (submaximal) in untrained subjects can modify haemostasis toward hypercoagulability, especially among women using oral contraceptives (OC). The aim of this study was to investigate whether this can be explained by platelet haemostasis and changes in the generation of membrane microparticles. Materials and method. Young, healthy women (n=60) were divided into 2 equal groups: a study group OC (+) who had used OC for >3 months, and controls who had never used oral contraceptives OC(-). Exclusion criteria: those with systematic daily physical activity. Participants were subjected to treadmill exercise (Cardiac Diagnostic System; model CH2000) using the Bruce protocol/ AHA guidelines. Platelet aggregation with arachidonic acid (ASPI test) or ADP (ADP test), membrane microparticle (MP) activity, plasma coagulation times (APTT/PT) and blood count were determined before and 45 minutes after exercise. Results. Before exercise, the OC(+) group had slightly higher platelet aggregation (ADP test), significantly lower MP activity, slightly lower PLT and slightly higher PDW rate. Exercise caused slight inhibition of platelet aggregation (ASPI test), and significant decrease in MP activity – only in the OC(-) group. After exercise, in both groups there was a significant decrease in PLT and increase in WBC, more pronounced in OC(+) group. Conclusions. Submaximal exercise was beneficial for haemostasis in women not using hormonal contraception, associated primarily with reduced MP activity. No beneficial effects of physical activity were found for women using hormonal contraceptives, possibly associated with a hypercoagulable state, and higher reactivity of blood platelets under the influence of the use of contraceptives.
Źródło:
Journal of Pre-Clinical and Clinical Research; 2017, 11, 1
1898-2395
Pojawia się w:
Journal of Pre-Clinical and Clinical Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of circulating microparticles in healthy medical workers occupationally exposed to ionizing radiation: A preliminary study
Autorzy:
Al-Massarani, Ghassan
Najjar, Fadi
Aljapawe, Abdulmunim
Ikhtiar, Adnan
Powiązania:
https://bibliotekanauki.pl/articles/2162036.pdf
Data publikacji:
2018-12-20
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
biomarkers
flow cytometry
occupational exposure
microparticles
ionizing radiation
cellular damage
Opis:
Objectives Ionizing radiation was known to cause disruption of cytoskeleton. However, the disorganization of the cytoskeleton leads to form microparticles (MP) that carry membrane and cytoplasmic constituents from their parent cells they are released from. Therefore, authors investigated the effect of the occupational exposure to low doses of ionizing radiation on MP levels. Material and Methods The current study was conducted on 38 healthy medical workers occupationally exposed to low doses of ionizing radiation and 29 controls matched by gender, age, and smoking habits. The MP levels measured by flow cytometry were classified as positive or negative phosphatidylserine (PS⁺ or PS⁻), and phenotyped according to their cellular origin. Results Total MP (PS–/PS+) levels, regardless of phenotype, were significantly higher in workers occupationally exposed to ionizing radiation than in healthy individuals (p = 0.0004). Negative phosphatidylserine microparticles were predominant in medical exposed workers and, to a lesser extent, in controls (68% and 57%, respectively). With regard to phenotypic characterization of cellular origin, MP derived from platelets (CD41a+), endothelial (CD146+), leucocytes (CD45+) and erythrocytes (CD235a+) MP were significantly enhanced in exposed workers compared with controls (p < 0.0001). However, no significant difference was found in the proportion of the other blood elements in the peripheral circulation between the 2 groups. Serum levels of C-reactive protein were normal for all individuals. In addition, no association was observed between MP levels and the studied confounding factors. Conclusions The results suggest that elevated circulating MP levels represent an indicator of cellular damage caused by medical exposure to low doses of ionizing radiation. By consequence, the quantification of MP seems to be a useful biomarker for assessing the negative effects of occupational exposure to ionizing radiation. Int J Occup Med Environ Health 2018;31(6):783–793
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2018, 31, 6; 783-793
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The use of LA-ICP-MS as an auxiliary tool to assess the pulmonary toxicity of molybdenum(IV) sulfide (MoS2) nano- and microparticles
Autorzy:
Kuraś, Renata
Stępnik, Maciej
Domeradzka-Gajda, Katarzyna
Janasik, Beata
Powiązania:
https://bibliotekanauki.pl/articles/28761978.pdf
Data publikacji:
2024-03-05
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
microparticles
LA-ICP-MS
molybdenum(IV) disulfide
bioimaging
rat tissues
nanoparticles
Opis:
Objectives Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has considerable applicative potential for both qualitative and quantitative analyses of elemental spatial distribution and concentration. It provides high resolutions at pg-level detection limits. These qualities make it very useful for analyzing biological samples. The present study responds to the growing demand for adequate analytical methods which would allow to assess the distribution of nanostructured molybdenum(IV) disulfide (MoS₂) in organs. It was also motivated by an apparent lack of literature on the biological effects of MoS₂ in living organisms. The study was aimed at using LA-ICP-MS for comparing micro- and nanosized MoS2 ditribution in selected rat tissue samples (lung, liver, brain and spleen tissues) after the intratracheal instillation (7 administrations) of MoS₂ nano- and microparticles vs. controls. Material and Methods The experimental study, approved by the Ethics Committee for Animal Experiments was performed using albino Wistar rats. This was performed at 2-week intervals at a dose of 5 mg/kg b.w., followed by an analysis after 90 days of exposure. The MoS₂ levels in control tissues were determined with the laser ablation system at optimized operating conditions. The parameter optimization process for the LA system was conducted using The National Institute of Standards and Technology (NIST) glass standard reference materials. Results Instrument parameters were optimized. The study found that molybdenum (Mo) levels in the lungs of microparticle-exposed rats were higher compared to nanoparticle-exposed rats. The opposite results were found for liver and spleen tissues. Brain Mo concentrations were below the detection limit. Conclusions The LA-ICP-MS technique may be used as an important tool for visualizing the distribution of Mo on the surface of soft samples through quantitative and qualitative elemental mapping.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2024, 37, 1; 18-33
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Improved adhesion and growth of osteoblast-like MG-63 cells in cultures on titanium modified by gold particles
Autorzy:
Parizek, M.
Base, T.
Hruby, M.
Lisa, V.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/285778.pdf
Data publikacji:
2013
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
metallic materials
titanium
surgical implants
gold microparticles
cell adhesion
cell growth
Opis:
Metallic materials are important for load-bearing bone implants. The osteointegration of these implants can be improved by appropriate surface modifications. Therefore, we present here a study of the cell growth on titanium surfaces modified with films created from gold microparticles. These particles in the form of microplates or polyhedral microcrystals were deposited on titanium plates from ethanol solutions, dried and annealed with a hydrogen flame. Some samples were additionally modified by polyethylene imine. The materials engendered from these modifications were used to investigate the adhesion and growth of human osteoblast-like MG-63 cells on these surfaces in the DMEM medium with 10% of fetal bovine serum. One day after seeding, the highest number of initially adhered cells was found on the surfaces modified by both types of gold microparticles. This trend was the same three and seven days after seeding. The numbers of cells on pure Ti and Ti modified only with gold particles were significantly higher than on samples which were modified with polyethylene imine. The cell spreading areas projected on the materials were significantly larger in cells on the samples with polyethylene imine modification. However, the shape of these cells was mostly rounded or star-like with thin and long protrusions, while on the materials without polyethylene imine, it was mostly polygonal. The cell proliferation activity was estimated from XTT test, based on the activity of mitochondrial enzymes. This test showed that the proliferation activities of osteoblast-like MG-63 cells of the 3rd and 7th days of the experiment were more pronounced on the samples modified only by gold microparticles. Immunofluorescence showed that the focal adhesion plaques containing vinculin and the fibers containing β-actin were most apparent, more numerous and more brightly stained in cells on Ti modified by gold microplates and gold polyhedral microcrystals, especially in comparison with the corresponding samples modified with polyethylene imine (Fig. 1). Thus, it can be concluded that the modification of titanium samples by both types of gold microparticles enhanced the adhesion and growth of MG 63 cells.
Źródło:
Engineering of Biomaterials; 2013, 16, no. 122-123 spec. iss.; 77
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Kompozyty na osnowie polietylenu niskiej gęstości z mikrocząstkami pochodzenia naturalnego
Composites based on low density polyethylene with natural microparticles
Autorzy:
Szewczyk, I.
Petlicka, D.
Kuciel, S.
Powiązania:
https://bibliotekanauki.pl/articles/279160.pdf
Data publikacji:
2017
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Inżynierii Materiałów Polimerowych i Barwników
Tematy:
recykling
LDPE
cząstki naturalne
właściwości wytrzymałościowe
recycling
natural microparticles
strength properties
Opis:
W pracy dokonano oceny możliwości wzmacniania polietylenu odpadowego niskiej gęstości różnymi rodzajami mikrocząstek pochodzenia naturalnego. W części doświadczalnej przedstawiono wyniki badań podstawowych właściwości fizyko-mechanicznych kompozytów recyklatu polietylenu niskiej gęstości wyprodukowanego przez ZPTS Kłaj, wzmacnianych mączką drzewną pochodzącą z drzew iglastych, tufem czerwonym, skorupkami jajek oraz piórami ptaków hodowlanych. Dodatek każdego z wypełniaczy zwiększa gęstość wytworzonych próbek, jak również polepsza wytrzymałość na zginanie, oraz wzrost modułu sprężystości przy rozciąganiu materiałów. Rezultaty te, uzyskano bez kompaudowania i wytwarzania granulatu. W zakończeniu wskazano potencjalne możliwości zastosowania nowych kompozytów.
The paper presents the assessment of the potential reinforcing of low density polyethylene with different type of natural microparticles. The experimental part presents the results of the basic physical and mechanical properties of low density polyethylene recycled composite materials produced by ZPTS Kłaj, reinforced with coniferous wood meal, red tuff, eggshell and poultry bird feathers. The addition of each of the fillers increases the density of the produced samples as well as improves the flexural strength and the increase of the tensile modulus of the materials. The results were obtained without compauding and manufacturing granules. In conclusion, the potential use of new composites is indicated.
Źródło:
Przetwórstwo Tworzyw; 2017, T. 23, Nr 5 (179), 5 (179); 442-449
1429-0472
Pojawia się w:
Przetwórstwo Tworzyw
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Curcumin delivery systems as dressing components for the treatment of diabetic foot ulcers: test on macrophages polarization
Autorzy:
Wójcik, Karolina
Kusibab, Anna
Sousa, Ana Beatriz
Barbosa, Judite Novais
Pamuła, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/27324039.pdf
Data publikacji:
2023
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
curcumin
immunomodulation
inflammation
macrophage polarization
polymeric microparticles
wound healing
makrofagi
polaryzacja
biomateriały
Opis:
The natural wound healing process consists of four basic phases: homeostasis, inflammation, proliferation, and remodelling. Macrophages play an important role in the body’s response to biomaterials, as they are modulators of the wound healing process and can polarize into different phenotypes capable of inducing both deleterious and beneficial effects on tissue repair. Curcumin (CU) is known for its anti-inflammatory properties and has the potential to treat diabetic foot ulcers, but it should be delivered to wounds in a controlled manner. In this study, the encapsulation of curcumin in polymeric microparticles based on poly(sebacic anhydride) (PSA) was developed using an emulsification method. PSA-based microparticles containing different concentrations of CU were obtained: 0% weight (wt). CU (unloaded microparticles), 5, 10, and 20 wt% CU. CU encapsulation efficiency and loading were determined using a fluorescence-based calibration curve method and semi-quantitative Fourier-transform infrared spectroscopy (FTIR) analysis. The potential cytotoxicity of the obtained biomaterials in contact with primary human macrophages and their susceptibility to polarization from the M1 (pro-inflammatory) phenotype to the M2 (antiinflammatory) phenotype were evaluated. The morphology of cells cultured in contact with polymeric microparticles was evaluated using phalloidin red and 4′,6-diamidino2-phenylindole (DAPI) staining. Macrophage phenotype was assessed using flow cytometry. The obtained biomaterials showed no cytotoxic effect on primary human macrophages. Flow cytometry studies showed enhanced polarization of macrophages into anti-inflammatory M2 phenotype when exposed to microparticles loaded with CU and CU powder as compared to unloaded microparticles
Źródło:
Engineering of Biomaterials; 2023, 26, 168; 15--24
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Composite scaffolds enriched with calcium carbonate microparticles loaded with epigallocatechin gallate for bone tissue regeneration
Autorzy:
Pietryga, Krzysztof
Panaite, Anca-Alexandra
Pamuła, Elżbieta
Powiązania:
https://bibliotekanauki.pl/articles/24200847.pdf
Data publikacji:
2022
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
gellan gum
gelatin
hydrogel
calcium carbonate microparticles
enzymatic mineralization
epigallocatechin gallate (EGCG)
Opis:
There is a need to develop advanced multifunctional scaffolds for the treatment of bone tissue lesions, which apart from providing support for infiltrating cells could assure the delivery of drugs or biologically active molecules enhancing bone formation. We developed composite scaffolds for bone tissue engineering based on gellan gum (GG) and gelatin (Gel) hydrogel enriched with epigallocatechin gallate (EGCG) loaded CaCO3 microparticles and subjected to enzymatic mineralization with calcium phosphate (CaP). The method of manufacturing CaCO3 microparticles was optimized. The EGCG-loaded microparticles were smaller than those unloaded, and the release of EGCG was prolonged for up to 14 days, as shown by the Folin-Ciocalteu test. The particles reduced the viability of the MG-63 cells as compared to the control. However, when they were loaded with EGCG, their cytotoxicity was reduced. The particles were suspended in a GG/Gel hydrogel containing alkaline phosphatase (ALP), soaked in calcium glycerophosphate (CaGP) solution to create CaP deposits, and submitted to freeze-drying, in order to produce a porous scaffold. The microstructure of the scaffolds was characterized by optical and scanning electron microscopy and showed that the size of the pores corresponds to that of the spongy bone. In vitro tests with MG-63 cells confirmed that mineralized scaffolds support cell adhesion and growth to a higher extent than nonmineralized ones.
Źródło:
Engineering of Biomaterials; 2022, 25, 166; 12--21
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Adhesive bond of carbon steel S235J0: effects of aluminium and polymer powder filled epoxy adhesives on mechanical properties
Autorzy:
Müller, M.
Valášek, P.
Powiązania:
https://bibliotekanauki.pl/articles/102623.pdf
Data publikacji:
2016
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
adhesive bond strength
SEM
microparticles filler
tensile strength
elongation
structural two-component epoxy
Opis:
The paper deals with the testing of composite materials based on aluminium and polymer microparticles. The aim of the research was to determine an influence of a content of a microparticle filler on mechanical properties of the polymer particle composite and adhesive bonds (material structural carbon steel S235J0). A preparation of adhesive bonds and a process of testing of the adhesive bonds were in accordance with the standard CSN EN 1465. The adhesive bond strength was increased when adding the aluminium and polymer powder filler. The adhesive bond strength increase was the highest at the adhesive bond with the adhesive in the form of the composite (15 g of the filler : 100 g of the matrix). The adhesive bond strength increase was 14.3% (13.68 ± 0.43 MPa). Adhesive bonds evinced an adhesive type of a fracture surface. By adding the filler in a form of microparticles there was a change of the failure type on adhesive-cohesive and a cohesive type. Fracture surfaces and an adhesive bond cut was examined with SEM (scanning electron microscopy) using a microscope MIRA 3 TESCAN.
Źródło:
Advances in Science and Technology. Research Journal; 2016, 10, 31; 87-93
2299-8624
Pojawia się w:
Advances in Science and Technology. Research Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Modelowanie suszenia rozpyłowego układów wieloskładnikowych
Modeling of spray dring of multicomponent systems
Autorzy:
Gac, J.
Gradoń, L.
Powiązania:
https://bibliotekanauki.pl/articles/2071494.pdf
Data publikacji:
2011
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
suszenie rozpyłowe
modelowanie numeryczne
mikrocząstki
aerozol leczniczy
spray drying
numerical modeling
microparticles
therapeutic aerosols
Opis:
Sformułowano model numeryczny suszenia rozpyłowego układów wieloskładnikowych, uwzględniający niejednorodność stężeń i temperatur oraz możliwość krystalizacji jednego ze składników. W wyniku przeprowadzonych symulacji stwierdzono, że dla małych kropli niejednorodności składu powstających cząstek są na ogól niewielkie. Większe niejednorodności mogą wystąpić w przypadku bardzo wysokiej temperatury powietrza suszącego oraz gdy rozpuszczalność jednego ze składników kropli jest stosunkowo niska.
The numerical model of spray drying, taking into account inhomogcncity of concentrations and temperature as well as possibility of crystallization of one of the component, has been built. As a result of simulations it has been found that for small droplets the inhomogeneity of composition of the particles produced are very small. Noticeable inhomogenities may appear only in the case of very high temperature of drying air or when the solubility of one of the droplet component of is quite small.
Źródło:
Inżynieria i Aparatura Chemiczna; 2011, 5; 32-33
0368-0827
Pojawia się w:
Inżynieria i Aparatura Chemiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Doświadczalne i numeryczne badanie wytwarzania cząstek o różnej morfologii w procesie suszenia rozpyłowego
Experimental and numerical study of the production of different morphology particles by means of spray drying process
Autorzy:
Gac, J.M.
Odziomek, M.
Sosnowski, T. R.
Gradoń, L.
Powiązania:
https://bibliotekanauki.pl/articles/2072819.pdf
Data publikacji:
2014
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
suszenie rozpyłowe
modelowanie numeryczne
mikrocząstki
aerozol leczniczy
spray drying
numerical modeling
microparticles
therapeutic aerosols
Opis:
Przedstawiono doświadczalne i numeryczne wyniki badania morfologii cząstek dekstranu otrzymywanych techniką suszenia rozpyłowego. W wyniku tego procesu można otrzymać cząstki puste w środku typu hollow particles o różnej średnicy oraz grubości powłoki (shell). Do opisu teoretycznego procesu suszenia zastosowano model o parametrach rozłożonych. Pozwolił on na przedstawienie wpływu, jaki na kształt i budowę cząstek wywierają takie parametry procesu, jak temperatura powietrza suszącego oraz wielkość kropli.
The paper presents the experimental and numerical results of dextran par¬ticles morphology obtained by means of spray drying method. This process can produce hollow particles which differ in diameter and shell thickness. For theoretical description of spray drying process the distributed parameter model was used. The model allowed one to present the influence of such process parameters as drying air temperature and droplet size on particle shape and its structure.
Źródło:
Inżynieria i Aparatura Chemiczna; 2014, 4; 241--242
0368-0827
Pojawia się w:
Inżynieria i Aparatura Chemiczna
Dostawca treści:
Biblioteka Nauki
Artykuł
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