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    Wyświetlanie 1-15 z 15
    Tytuł:
    Lab-on-a-chip microdevice with contactless conductivity detector
    Autorzy:
    Blaszczyk, K.
    Chudy, M.
    Brzozka, Z.
    Dybko, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/221617.pdf
    Data publikacji:
    2013
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    lab-on-a-chip
    poly(dimethylsiloxane)
    contactless conductivity
    pseudoelectrodes
    microfluidic
    Opis:
    This paper describes a new contactless conductivity detector, whose electrodes are constructed of microchannels filled with solution of KCl - called pseudoelectrodes. The lab-on-a-chip microdevice was fabricated in poly(dimethylsiloxane) PDMS, using a moulding technique. The mould was made from a dry negative photoresist with a thickness of 50 µm. During the tests, the dimension and arrangement of pseudoelectrodes' microchannels were evaluated. The analyte was pumped into the microchannel using a syringe pump with a flow rate of 50 µL/min. Reproducible changes of the signal were obtained.
    Źródło:
    Metrology and Measurement Systems; 2013, 20, 2; 299-306
    0860-8229
    Pojawia się w:
    Metrology and Measurement Systems
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Study on the Effect of in Situ Surface Treatments of Medical Microfluidic Systems Obtained Through Additive Manufacturing
    Autorzy:
    Csapai, Alexandra
    Țoc, Dan-Alexandru
    Pașcalău, Violeta
    Toșa, Victor
    Opruța, Dan
    Popa, Florin
    Popa, Catalin
    Powiązania:
    https://bibliotekanauki.pl/articles/2134105.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    additive manufacturing
    microfluidic systems
    surface roughness
    biofilm growth
    laminar flow
    Opis:
    This paper presents a comparative study on the effects of the in-situ surface modifications performed on “H” type microfluidic systems obtained via additive manufacturing. The microsystem was printed using a polylactic acid filament on an Ender-5 Pro printer. The surface modification of the main channel was done using chloroform by two different methods: vapor smoothing and flushing. The obtained surface roughness was studied using an optical microscope and the ImageJ software, as well as scanning electron microscopy. The effect of the channel surface treatment upon the characteristics of the fluid flow was assessed. The microfluidic systems were used for the dynamic study of biofilm growth of Candida albicans (ATCC 10231). The influence of the surface roughness of the main channel on the formation and growth of the biofilm was studied using quantitative methods, scanning electron microscopy imaging as well as optical coherence tomography.
    Źródło:
    Archives of Metallurgy and Materials; 2022, 67, 3; 1071--1078
    1733-3490
    Pojawia się w:
    Archives of Metallurgy and Materials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Numerical study of droplet formation in a Y-junction microchannel
    Autorzy:
    Diouf, M. M. L.
    Romero, O. J.
    Powiązania:
    https://bibliotekanauki.pl/articles/281676.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Mechaniki Teoretycznej i Stosowanej
    Tematy:
    microfluidic
    Y-junction
    two-phase flow
    numerical simulation
    VOF
    Opis:
    This study investigates the formation process of droplets in a Y-junction microchannel using two immiscible fluids: water as the continuous fluid and oil as the dispersed phase. We have examined the influence of the capillary number, flow rate ratio and viscosity ratio between the two fluids; parameters which determine the length and generation frequency of the droplets. Numerical simulations have been performed using the software Ansys Fluent with the interface capture method Volume of Fluid (VOF) for solving the governing equations. Three different algorithms have been tested for the pressure-velocity coupling: SIMPLE, SIMPLEC and PISO. The results are quite similar for SIMPLE and SIMPLEC, however it turned out that PISO is a better algorithm to solve the two-phase flow. Additionally, another Y-junction is coupled in the initial geometry to observe a symmetric breakup of the droplets and their formation is explained using the pressure field and the velocity field.
    Źródło:
    Journal of Theoretical and Applied Mechanics; 2017, 55, 1; 317-330
    1429-2955
    Pojawia się w:
    Journal of Theoretical and Applied Mechanics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Transient velocity and steady state entropy generation in a microfluidic Couette flow containing charged nano particles
    Autorzy:
    Gorla, R. S. R.
    Gireesha, B. J.
    Powiązania:
    https://bibliotekanauki.pl/articles/264851.pdf
    Data publikacji:
    2015
    Wydawca:
    Uniwersytet Zielonogórski. Oficyna Wydawnicza
    Tematy:
    transient velocity
    steady state entropy generation
    microfluidic Couette flow
    charged nanoparticles
    Bejan number and Brinkman number
    przepływ Couette'a
    liczba Brinkmana
    nanocząsteczki
    Opis:
    An analysis has been provided to determine the transient velocity and steady state entropy generation in a microfluidic Couette flow influenced by electro-kinetic effect of charged nanoparticles. The equation for calculating the Couette flow velocity profile is derived for transient flow. The solutions for momentum and energy equations are used to get the exact solution for the dimensionless velocity ratio and dimensionless entropy generation number. The effects of the dimensionless entropy generation number, Bejan number, irreversibility ratio, entropy generation due to fluid friction and due to heat transfer on dimensionless time, relative channel height, Brinkman number, dimensionless temperature ratio, nanoparticle volume fraction are analyzed.
    Źródło:
    International Journal of Applied Mechanics and Engineering; 2015, 20, 4; 787-804
    1734-4492
    2353-9003
    Pojawia się w:
    International Journal of Applied Mechanics and Engineering
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Microfluidic devices — application in anticancer studies
    Autorzy:
    Jędrych, E.
    Chudy, M.
    Dybko, A.
    Brzózka, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/115929.pdf
    Data publikacji:
    2012
    Wydawca:
    Fundacja na Rzecz Młodych Naukowców
    Tematy:
    microfluidic system
    PDMS
    adherent cell culture
    concentration gradient generator (CGG)
    cytotoxicity tests
    photodynamic therapy (PDT) procedures
    Opis:
    A rapidly growing pharmaceutical industry requires faster and more efficient ways to find and test new drugs. One of the new method for cell culture and examining the toxic effects of drugs is application of microfluidic systems. They provide new types of microenvironments and new methods for investigation of anticancer therapy. The use of microsystems is a solution that gives the opportunity to reduce not only cost and time, but also a number of tests on animals. In this paper we present designed and fabricated hybrid microfluidic systems which are applicable for cell culture, cell based cytotoxicity assays and photodynamic therapy procedures. Polydimethylsiloxane (PDMS) and sodium glass were used for fabrication of microdevices. The designed geometry of the microdevices includes cell culture microchambers and a concentration gradient generator (CGG). The CGG enables to obtain diff erent concentrations of tested drugs in a single step, which is a significant simplification of cytotoxicity assay procedure. In the designed microsystems three various cell lines (normal and carcinoma) were cultured and analyzed.
    Źródło:
    Challenges of Modern Technology; 2012, 3, 2; 3-5
    2082-2863
    2353-4419
    Pojawia się w:
    Challenges of Modern Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    New microfluidic device for lactate dehydrogenase (LDH) activity analysis
    Autorzy:
    Jędrych, E.
    Mazur, M.
    Grabowska-Jadach, I.
    Brzózka, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/115778.pdf
    Data publikacji:
    2012
    Wydawca:
    Fundacja na Rzecz Młodych Naukowców
    Tematy:
    lactate dehydrogenase (LDH) activity
    microfluidic system
    PDMS
    adherent cell culture
    cytotoxicity analysis
    Opis:
    In this paper, we present cytotoxicity analysis (determination of lactate dehydrogenase — LDH activity performed in a designed and fabricated microfl uidic system. This method allowed for analysis of a supernatant collected from A549 (human lung cancer) and HT-29 (human colon cancer epithelial) cells, which were incubated for 24 h with selected compounds. LDH is an intracellular enzyme present in tissues, which is released into the supernatant caused by membrane damage or cell lyses. In our tests, LDH-Cytotoxicity Assay Kit (BioVision) was used. The toxic eff ect of drugs was measured in the developed microsystem made of PDMS (poly(dimethylsiloxane)). Analytical reaction took place in the special designed microchannel geometry. Then, the LDH activity was measured at 490 nm using spectrophotometer. In subsequent experiments, appropriate conditions for measurements using a microfl uidic system were chosen. It was found that the selected reagent is sensitive to temperature changes and light exposure. Reaction time in the microsystem was determined by changes of fl ow rates of reagents. Afterwards, for the various reaction time, the toxic eff ect of 5-fl uorouracil, celecoxib and 1,4-dioxane was performed. The obtained results were compared with the results carried out in 96-well plates. Based on these results, it was noted that the enzymatic reaction time in the microsystem is shorter than in 96-well plate. Moreover, the advantage of using microsystem is also the small amount of reagents.
    Źródło:
    Challenges of Modern Technology; 2012, 3, 4; 3-8
    2082-2863
    2353-4419
    Pojawia się w:
    Challenges of Modern Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Integration of optoelectronic components with LTCC (low temperature co-fired ceramic) microfluidic structure
    Autorzy:
    Malecha, K.
    Powiązania:
    https://bibliotekanauki.pl/articles/220539.pdf
    Data publikacji:
    2011
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    LTCC (low temperature co-fired ceramics)
    microfluidic
    absorbance
    CFD Computational Fluid Dynamics
    Opis:
    Investigations on integration of optoelectronic components with LTCC (low temperature co-fired ceramics) microfluidic module are presented. Design, fabrication and characterization of the ceramic structure for optical absorbance is described as well. The geometry of the microfluidic channels has been designed according to results of the CFD (computational fluid dynamics) analysis. A fabricated LTCC-based microfluidic module consists of an U-shaped microchannel, two optical fibers and integrated light source (light emitting diode) and photodetector (light-to-voltage converter). Properties of the fabricated microfluidic system have been investigated experimentally. Several concentrations of potassium permanganate (KMnO4) in water were used for absorbance/transmittance measurements. The test has shown a linear detection range for various concentrations of heavy metal ions in distilled water. The fabricated microfluidic structure is found to be a very useful system in chemical analysis.
    Źródło:
    Metrology and Measurement Systems; 2011, 18, 4; 713-721
    0860-8229
    Pojawia się w:
    Metrology and Measurement Systems
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Microfluidic design for continuous separation of blood particles and plasma using dielectrophoretic force principle
    Autorzy:
    Pakhira, Writtick
    Kumar, Rajagopal
    Panwala, Fenil Chetankuma
    Ibrahimi, Khalid Mohd
    Powiązania:
    https://bibliotekanauki.pl/articles/38702917.pdf
    Data publikacji:
    2023
    Wydawca:
    Instytut Podstawowych Problemów Techniki PAN
    Tematy:
    blood cell separation
    dielectrophoresis
    microfluidic device
    plasma separation
    separacja komórek krwi
    dielektroforeza
    urządzenie mikroprzepływowe
    separacja plazmy
    Opis:
    Nowadays, various microfluidic platforms are developed with a focus on point-of-care diagnostics in the biomedical field. Segregation of blood cells and plasma remains an essential part of medical diagnosis in which isolation of platelets (PLTs), red blood cells (RBCs), and white blood cells (WBCs) is a requirement for analysis of diseases associated with thrombocytopenia, anemia, and leukopenia. However, a separated plasma contains proteins, nucleic acids, and viruses, for which a microfluidic device is introduced for continuous separation of PLTs, RBCs, and WBCs with a diameter range of 1.8–2 m, 5–6 m, and 9.4–14 m, respectively, and plasma using the negative dielectrophoresis (DEP) force principle. In this study, design of the device is explored utilizing COMSOL Multiphysics 5.4 tool. This design consists of triangular micro-tip electrodes at the top, which are effective in generating a nonuniform electrical field with a significantly small AC voltage. Furthermore, the blood cells are subjected to the negative DEP force resulting in deflection toward their respective outlets, due to which blood cell separation purity and efficiency from the sample, i.e., of PLTs, RBCs, and WBCs, improve and are obtained at a blood sample flow velocity of 700 m/s and buffer solution flow velocity of 1200 m/s with 12 Vpp electrode voltage, after experimenting and testing at multiple flow velocities. Additionally, a curved microchannel is introduced, producing better plasma flow velocity than a flat microchannel at the side outlets (top and bottom). The cell-free diluted plasma is collected at side outlets (top and bottom) with high purity and improved separation efficiency.
    Źródło:
    Computer Assisted Methods in Engineering and Science; 2023, 30, 3; 323-345
    2299-3649
    Pojawia się w:
    Computer Assisted Methods in Engineering and Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Inżynieria komórkowa w systemach lab-on-a-chip
    Cell engineering in lab-on-chip systems
    Autorzy:
    Tomecka, E.
    Tokarska, K.
    Jastrzębska, E.
    Chudy, M.
    Brzózka, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/172147.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Chemiczne
    Tematy:
    inżynieria komórkowa
    mikrosystemy przepływowe
    dwuwymiarowa hodowla komórkowa
    trójwymiarowa hodowla komórkowa
    cell engineering
    microfluidic systems
    two-dimensional cell culture
    three-dimensional cell culture
    Opis:
    Lab-on-a-chip systems are promising tools in the field of cell engineering. Microfluidic systems are integrated microlaboratories consisting of many microstructures such as microchannels and microchambers, which can be used for cell analysis and cell culture. Appropriately designed geometry of the chip allows to mimic in vivo conditions. Microsystems enables continuous culture medium perfusion. During cell culture, regulation of the flow rate of medium is possible, which allows to control conditions of the cultivation. In this paper we present a review of microfluidics systems which are used in cell engineering. We describe methods of microsystems fabrication, parameters which influence cell proliferation in microscale and examples of microsystems for cell analysis and cell culturing. Microfluidic systems for maintaining cell culture are mainly fabricated of poly(dimethylsiloxane) (PDMS) and glass, non-toxic materials for cells. The most commonly used method for fabrication of PDMS microsystems is photolithography and replica molding techniques. Cell culture in microsystems can be carried out in two ways: as a two-dimensional (2D) cell culture and three-dimensional (3D) cell culture. In two-dimensional culture cells grow as a monolayer on a flat surface of microchambers or microchannels. Microsystems for two-dimensional cell culture are widely described in the literature. They are mainly used for: (i) cell proliferation after exposure to external stimuli, (ii) testing the activity of cytotoxic drugs, (iii) interactions and cell migration and (iv) the evaluation of procedures applicable in tumor therapy e. g. photodynamic therapy. However, two-dimensional cell culture do not mimic fully in vivo conditions. In living organisms cells grow spatially creating three-dimensional structures like tissues. Therefore, nowadays microsystems for 3D cell culture are being developed intensively. Three-dimensional cell culture in microfluidic systems can be achieved in three ways: by the design of suitable geometry and topography of microchannels, by the use of hydrogels or by spheroids formation. Three-dimensional cell culture in microfluidic systems are much better experimental in vitro models than cell culture in traditional culture vessels. It is the main reason why microsystems should be still improved, as to become widely used research tools in cellular engineering.
    Źródło:
    Wiadomości Chemiczne; 2015, 69, 9-10; 909-929
    0043-5104
    2300-0295
    Pojawia się w:
    Wiadomości Chemiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Design and fabrication of 125I seeds for brachytherapy using capillary-based microfluidic technique
    Autorzy:
    Wang, Yuan
    Zhang, Miao
    Song, Tong
    Chang, Zhenqi
    Powiązania:
    https://bibliotekanauki.pl/articles/2055673.pdf
    Data publikacji:
    2021
    Wydawca:
    Instytut Chemii i Techniki Jądrowej
    Tematy:
    125I seeds
    brachytherapy source
    microfluidic
    Monte Carlo calculation
    core-shell
    Opis:
    A new kind of 125I seeds with a core-shell structure were synthesized by an easy assembling–disassembling coaxial capillaries microfluidic device. The dose distribution of a 125I brachytherapy source fabricated by arranging six 125I seeds collinearly within a cylindrical titanium capsule was simulated by modelling the source in a water phantom using Monte Carlo N-Particle Transport code. The infl uence of the motion and the core size of the 125I seeds on the dose distribution was also studied in this work.
    Źródło:
    Nukleonika; 2021, 66, 2; 55--60
    0029-5922
    1508-5791
    Pojawia się w:
    Nukleonika
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Precipitation of fluorescent micro- and nano- crystals in polysaccharide shell
    Precypitacja mikro- i nanokryształów fluorescencyjnych w otoczce polisacharydowej
    Autorzy:
    Wasiak, I.
    Fery-Forgues, S
    Ciach, T.
    Powiązania:
    https://bibliotekanauki.pl/articles/2072987.pdf
    Data publikacji:
    2014
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    mikrokryształy organiczne
    reprecypitacja
    mikroukład
    organic microcrystals
    reprecipitation
    microfluidic system
    Opis:
    Development of organic micro- and nanocrystals is rapidly expanding field due to their potential use in new technology devices in the field of chemistry and life science. Two methods of organic crystals preparation for future modification with polysaccharides used for cancer detection are compared in the paper. Both reprecipitation methods allow one to obtain microcrystals with a similar size range. However, the use of microfluidic system and polysaccharides solution reduces aggregates formation and leads to obtain narrow size distribution crystals.
    Rozwój metod otrzymywana organicznych mikro-i nanokryształów wynika z ich potencjalnego zastosowania w obszarze nowych technologii, chemii i nauk przyrodniczych. W pracy porównano dwie metody otrzymywania kryształów dla przyszłych modyfikacji polisacharydami w celu wykrywania nowotworów. Obie proponowane metody umożliwiają uzyskanie mikrokryształów o zbliżonym rozkładzie wielkości. Zastosowanie mikroukładu i roztworu polisacharydu zmniejsza liczbę powstających agregatów i prowadzi do uzyskania kryształów o wąskim rozkładzie średnic.
    Źródło:
    Inżynieria i Aparatura Chemiczna; 2014, 4; 316--317
    0368-0827
    Pojawia się w:
    Inżynieria i Aparatura Chemiczna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    3D simulations of diamond microfluidic devices
    Autorzy:
    Witkowski, D.
    Obidowski, D.
    Łysko, J.
    Karczemska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/285490.pdf
    Data publikacji:
    2009
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    przyrządy mikrofluidyczne
    Coventor
    ciepło Joule'a
    diamond microfluidic devices
    Joule heating
    Opis:
    The aim of this study was to optimize the diamond microfluidic device with four microchannels. The temperature distributions in electrophoretic microchips of different geometries and different materials have been analyzed by the Coventor software. Diamond microfluidic devices are very advantageous over glass or polymer microfluidic devices; they dissipate Joule heat much more efficiently because of the highest thermal conductivity coefficient of diamond.
    Źródło:
    Engineering of Biomaterials; 2009, 12, 86; 14-16
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Micro-Particle Image Velocimetry for imaging flows in passive microfluidic mixers
    Autorzy:
    Witkowski, D.
    Kubicki, W.
    Dziuban, J. A.
    Jašíková, D.
    Karczemska, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/221227.pdf
    Data publikacji:
    2018
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    micro-Particle Image Velocimetry
    microfluidics
    microfluidic devices
    Opis:
    The micro-Particle Image Velocimetry (micro-PIV) was used to measure flow velocities in micro-channels in two passive micromixers: a microfluidic Venturi mixer and a microfluidic spiral mixer, both preceded by standard “Y” micromixers. The micro-devices were made of borosilicate glass, with micro-engineering techniques dedicated to micro-PIV measurements. The obtained velocity profiles show differences in the flow structure in both cases. The micro-PIV enables understanding the micro-flow phenomena and can help to increase reproducibility of micromixers in mass production.
    Źródło:
    Metrology and Measurement Systems; 2018, 25, 3; 441-450
    0860-8229
    Pojawia się w:
    Metrology and Measurement Systems
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Two-dimensional model of fluid flow and distribution of nutrient concentration in a microfluidic device
    Autorzy:
    Wroniszewski, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/1934016.pdf
    Data publikacji:
    2011
    Wydawca:
    Politechnika Gdańska
    Tematy:
    microfluidic device
    lab-on-a-chip
    advection-diffusion equation
    Taylor dispersion
    Opis:
    During the past few years, the process of miniaturisation in the field of biochemical laboratory equipment led to the introduction of the so-called "lab-on-a-chip" microdevices, which combine separate functional units into a complex, multifunctional apparatus. Fluid dynamics plays an essential role in the development of such equipment, since frequently the major part of chemical analysis is based on soluble analytes. In this work, we consider a device for the analysis of cell growth under different conditions. In this device, dozens of cell spots absorb the nutrient (analyte) from the liquid medium. The concentration of the analyte must be strictly controlled to maintain a specific microenvironment. A two-dimensional model for the flow field and the distribution of concentration of the analyte is developed taking into account the geometrical shape of the spot with a simplified absorption model. The dependence of the results on the controlling parameters is investigated in order to determine the influence of the presence of the cell spot on the distribution of the analyte.
    Źródło:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2011, 15, 2; 135-155
    1428-6394
    Pojawia się w:
    TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    ‘Lab-on-a-chip’ for cell engineering: towards cellular models mimicking in vivo
    Autorzy:
    Ziółkowska, K.
    Chudy, M.
    Dybko, A.
    Brzózka, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/115885.pdf
    Data publikacji:
    2011
    Wydawca:
    Fundacja na Rzecz Młodych Naukowców
    Tematy:
    Lab-on-a-chip
    microfluidic tools
    cancer
    cell culture
    Multicellular Tumor Spheroid (MCTS)
    Opis:
    One of the main scopes of modern cell engineering is development of cellular models that can replace animals in drug screening and toxicological tests, so called alternative methods. Construction of the alternative model is a very challenging task due to a richness of factors creating the in vivo environment. The monolayer cell culture — cultivation of adhesive cells on artificial surfaces such as glass or polymer — lack most of the in vivo-like interactions, but still is the only tool for the majority of applications. One of the most prospective approaches on mimicking in vivo environment is “Lab-on-a-chip” technology. Microfluidic devices offer lots of advantages over traditional in vitro culture, e.g. much higher cell volume-to-extracellular fluid volume ratio or possibility of regulation of hydrodynamic stress. This presentation aims to introduce latest advances of our team in microfluidic cell culture devices. Our novel approach is to cultivate three dimensional multicellular aggregates (spheroids) in microenvironments arranged in a microfluidic system. The geometry and materials of the system allow for cultivation, observation and analysis of multicellular spheroids. The results presented concern multicellular tumor spheroids (MCTS) rising from human cancer cells, which are considered to represent most of the conditionings of cancer tumor in vivo. The fully developed MCTS microdevice will be a reliable tool for anticancer drug screening, as the results most likely will be in a close accordance with the results obtained in vivo.
    Źródło:
    Challenges of Modern Technology; 2011, 2, 1; 79-82
    2082-2863
    2353-4419
    Pojawia się w:
    Challenges of Modern Technology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-15 z 15

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