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Tytuł:
Analysis of mutations in the p16/ CDKN2A gene in sporadic and familial melanoma in the Polish population.
Autorzy:
Lamperska, Katarzyna
Karczewska, Aldona
Kwiatkowska, Eliza
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043764.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
familial melanoma
melanoma
mutations
CDKN2A
Opis:
Mutations in CDKN2A have been found in sporadic cutaneous malignant (CMM), in familial CMM and in other syndromes associated with melanoma. In this study DNA was obtained from 207 individuals and five cell lines. There were 157 CMM patients and 50 healthy members of melanoma patients families. The CMM group included patients with one or two melanoma cases in the family, families with dysplastic nevus syndrom (DNS) and patients with a spectrum of other types of cancers in the family. PCR-SSCP analysis and sequencing identified: six substitutions in codon 58 CGA/TGA (Arg/Stop), 16 substitutions GAC/GAT in codon 84 (Asp/Asp), six substitutions CGA /TGA in codon 148 (Arg/Thr), 14 substitutions G/C in 3'UTR and 4 double changes (two in codon 84 and 3'UTR; two in codon 148 and 3'UTR). The mutation identified in codon 58 was found in tissue only. Other substitutions were polymorphisms found in DNA from tissue and blood samples. Most of them were identified in sporadic CMM (six in codon 148 Ala /Thr, 12 in codon 84 Asp/Asp and six in 3'UTR). The frequency of the polymorphisms was also high in DNS and CMM/DNS families (four in codon 84 Asp/Asp and six in 3'UTR). No mutations or polymorphisms were found in CMM patients with one or two melanoma cases and CMM patients, with other cancers in family history. The analysis of the CDKN2A gene mutations in the Polish population demonstrated: (i) no germline mutations; (ii) a relatively high number of genetic changes in sporadic melanoma; (iii) a high number of polymorphisms in DNS and CMM/DNS families.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 369-376
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Current clinical management of malignant melanoma – diagnosis process and innovative therapies
Autorzy:
Kwiatkowski, Stanisław
Przystupski, Dawid
Kotowski, Krzysztof
Kolasińska, Karolina
Saczko, Jolanta
Kulbacka, Julita
Powiązania:
https://bibliotekanauki.pl/articles/1177464.pdf
Data publikacji:
2018
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
AJCC
Melanoma malignum
dabrafenib
electrochemotherapy
ipilimumab
melanoma
melanoma staging
pembrolizumab
photodynamic therapy
vemurafenib
Opis:
Malignant melanoma is a highly invasive cancer which derives from neuroectodermic melanocytic cells. It is characterized by the highest frequency of cases in both sexes and all age groups. High metastatic potential of melanoma and its multidrug resistance might be a significant problem in the treatment. Permanent and complete remissions are rare, while the 5-year survival rate remains relatively low. In the last years there has been a breakthrough in the systemic therapy of malignant melanoma. Modern drugs have revolutionized previous therapeutic management of melanoma. As part of therapeutic programs, new medicines are available: dabrafenib, ipilimumab, pembrolizumab, trametinib and vemurafenib. The following paper presents current clinical management standards for melanoma diagnoses, based on the widely accepted scientific data and expert experience - with emphasis on modern methods of treatment of this cancer.
Źródło:
World Scientific News; 2018, 102; 30-46
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.
Autorzy:
Drzewiecka, Agnieszka
Urbańska, Krystyna
Matuszak, Zenon
Pineiro, Marta
Arnaut, Luis
Habdas, Jan
Ratuszna, Alicja
Stochel, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1044198.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
porphyrins
photodynamic therapy
Opis:
We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off <630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm2 dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.
Źródło:
Acta Biochimica Polonica; 2001, 48, 1; 277-282
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Advanced skin melanoma – systemic treatment
Autorzy:
Kruczała, Maksymilian
Ziobro, Marek
Grela-Wojewoda, Aleksandra
Cedrych, Ida
Powiązania:
https://bibliotekanauki.pl/articles/1065316.pdf
Data publikacji:
2015
Wydawca:
Medical Education
Tematy:
immunotherapy
melanoma
systemic therapy
Opis:
In Poland, morbidity and mortality rates for melanoma are constantly increasing. In the case of inoperable disease or distant metastases, prognosis remains poor. For many years, dacarbazine has been the gold standard in systemic treatment. Recently, a significant progress in melanoma therapy has been observed. Introducing targeted therapy or immunotherapy significantly improved treatment outcomes. This review paper presents current knowledge on systemic treatment of advanced melanoma, including treatment availability in Poland.
Źródło:
OncoReview; 2015, 5, 3; A133-138
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas.
Autorzy:
Urbanska, Krystyna
Romanowska-Dixon, Bożena
Matuszak, Zenon
Oszajca, Janusz
Nowak-Sliwinska, Patrycja
Stochel, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1043767.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
photodynamic therapy
indocyanine green
Opis:
Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human (SKMEL 188) and mouse (S91) melanoma cells. The surviving fraction of the cells irradiated (λex = 830 nm) vs non-irradiated, treated with the same dose of ICG, is significantly decreased (5- to 10-fold). These results show that ICG is a very promising dye for photodynamic therapy of melanomas.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 387-391
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Recombinant angioarrestin secreted from mouse melanoma cells inhibits growth of primary tumours
Autorzy:
Smagur, Andrzej
Szary, Jarosław
Szala, Stanisław
Powiązania:
https://bibliotekanauki.pl/articles/1041334.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
angioarrestin
anti-angiogenic factor
Opis:
Angioarrestin is a recently described anti-angiogenic protein whose expression is down-regulated in solid tumours of various origins. It has a sequence identical to angiopoietin related protein-1. In this study we investigated anti-tumour properties of angioarrestin in B16 (F10) melanoma tumour model. We constructed an expression vector encoding human angioarrestin under the control of EF-1α promoter. This vector was transferred to B16 (F10) cells and recombinant angioarrestin secreted from the transfected cells was tested for anti-angiogenic activity using endothelial cell proliferation assay. Finally, mice were injected subcutaneously with cells that had been transfected with either angioarrestin-encoding vector or empty vector and tumor growth was compared. The obtained recombinant angioarrestin inhibited proliferation of bovine aortic endothelial cells. Tumours derived from an angioarrestin-secreting B16 (F10) cell clone grew in vivo more slowly than tumours derived from a cell clone transfected with empty vector. These data show, to our knowledge for the first time, that angioarrestin can inhibit primary melanoma tumour growth.
Źródło:
Acta Biochimica Polonica; 2005, 52, 4; 875-879
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Iris melanoma in a Labrador retriever
Melanocytoma tęczówki u psa rasy labrador retriever
Autorzy:
Kanemaki, N.
Powiązania:
https://bibliotekanauki.pl/articles/9952.pdf
Data publikacji:
2012
Wydawca:
Okulistyka Weterynaryjna
Tematy:
animal disease
eye disease
dog
Labrador retriever dog
melanoma
ocular melanoma
tumour
iris
Opis:
U psów stosunkowo często spotykamy w gałce ocznej czerniaki. W przeciwieństwie do czerniaków występujących u kotów, u psów rzadko dają one przerzuty. Wczesne wykrycie tego typu zmian w oku zapobiega dalszym komplikacjom. Praca ta przedstawia przypadek czerniaka tęczówki u psa rasy labrador retriever. Początkowo zmianę tęczówki leczono steroidami i antybiotykami. Lecz leczenie to nie przyniosło oczekiwanych rezultatów. Dalsze diagnozowanie (ultrasonografia, gonioskopia) wykazało, że jest to czerniak. Wykonano resekcję części tęczówki. Siedem tygodni po resekcji zmiany, powrócił odruch źreniczny i widzenie. Badanie histopatologiczne wykazało, że usunięta zmiana to melanocytoma.
Źródło:
Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii; 2012, 1
2082-9256
Pojawia się w:
Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carbohydrate moieties of N-cadherin from human melanoma cell lines.
Autorzy:
Ciołczyk-Wierzbicka, Dorota
Gil, Dorota
Hoja-Łukowicz, Dorota
Lityńska, Anna
Laidler, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1043705.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
N-cadherin
N-glycans
Opis:
Expression of N-cadherin an adhesion molecule of the cadherin family, in tumor cells is associated with their increased invasive potential. Many studies suggested the role of N-linked oligosaccharides as important factors that contribute to metastasis by influencing tumor cell invasion and adhesion. N-cadherin is a heavily glycosylated protein. We have analysed the carbohydrate profile of this protein synthesized in human melanoma cell lines: WM35 from the primary tumor site and WM239, WM9, and A375 from different metastatic sites. N-cadherin was immunoprecipitated with anti-human N-cadherin polyclonal antibodies. Characterisation of its carbohydrate moieties was carried out by SDS/PAGE electrophoresis and blotting, followed by immunochemical identification of the N-cadherin polypeptides and analysis of their glycans using highly specific digoxigenin or biotin labelled lectins. The positive reaction of N-cadherin from the WM35 cell line with Galanthus nivalis agglutinin (GNA), Datura stramonium agglutinin (DSA) and Sambucus nigra agglutinin (SNA) indicated the presence of high-mannose type glycans and biantennary complex type oligosaccharides with α2-6 linked sialic acid. N-cadherin from WM239, WM9, and A375 cell lines gave a positive reaction with Phaseolus vulgaris leukoagglutinin (L-PHA) and lotus Tetragonolobus purpureas agglutinin (LTA). This indicated the presence of tri- or tetra-antennary complex type glycans with α-fucose. In addition, N-cadherin from WM9 (lymphomodus metastatic site) and A375 (solid tumor metastatic site) contained complex type chains with α2-3 sialic acid (positive reaction with Maackia amurensis agglutinin - MAA). The results demonstrated that N-glycans of N-cadherin are altered in metastatic melanomas in a way characteristic for invasive tumor cells.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 991-998
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Management challenges and therapeutic strategies for metastatic melanoma – a case report
Autorzy:
Aglio, Andrea M.
Cracchiolo, Salvatore
Impellizzeri, Giuseppe
Górecki, Michał
Powiązania:
https://bibliotekanauki.pl/articles/29519536.pdf
Data publikacji:
2023-09-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
metastatic melanoma
peritoneal metastases
immunotherapy
Opis:
Introduction and aim. This case report focuses on a 26-year-old female with metastatic melanoma. It highlights the diagnostic process, initial immunotherapy, disease progression, and successful response to second-line therapy. Emphasizing the importance of early detection, personalized treatment, and adaptive strategies, it provides valuable insights into managing this aggressive form of skin cancer. Description of the case. A 26-year-old Caucasian female presented with a suspicious pigmented lesion on her thigh in 2013. The lesion was confirmed as superficial skin melanoma. No lymph node biopsy was performed. In 2021, she had abdominal pain and imaging revealed melanoma metastasis in the peritoneum, lungs and brain. Genetic testing showed BRAF V600E mutation and PD-L1 expression in tumor cells. She received immunotherapy and radiation for a central nervous system metastases but developed a brain hematoma. Follow-up imaging showed disease progression. She started second-line therapy with iBRAF/iMEK, and her condition rapidly improved with regression of metastatic lesions. Follow-up imaging confirmed significant positive changes and almost complete regression of neoplastic lesions. She continues to receive the targeted therapy and shows a positive response. Conclusion. Early diagnosis improves outcomes in metastatic melanoma. Peritoneal metastases should be considered in patients with abdominal symptoms. The combination of gamma knife radiosurgery with immunotherapy or targeted therapy shows promise for managing brain metastases, but careful patient selection and monitoring are vital due to potential risks. Treatment responses in advanced melanoma vary, with this case highlighting a favorable response to BRAF/MEK inhibitor therapy in a patient with a BRAF gene mutation. Further research and clinical trials are needed to refine treatment approaches and improve outcomes in metastatic melanoma.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 3; 663-668
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diagnosing skin melanoma: current versus future directions
Autorzy:
Hippe, Z. S.
Bajcar, S.
Blajdo, P.
Grzymała-Busse, J. P.
Grzymała-Busse, J. W.
Knap, M.
Paja, W.
Wrzesień, M.
Powiązania:
https://bibliotekanauki.pl/articles/1954638.pdf
Data publikacji:
2003
Wydawca:
Politechnika Gdańska
Tematy:
melanoma
TDS
machine learning in diagnosis
Opis:
A new database containing 410 cases of nevi pigmentosi, in four categories: benign nevus, blue nevus, suspicious nevus and melanoma malignant, carefully verified by histopathology, is described. The database is entirely different from the base presented previously, and can be readily used for research based on the so-called constructive induction in machine learning. To achieve this, the database features a different set of thirteen descriptive attributes, with a fourteenth additional attribute computed by applying values of the remaining thirteen attributes. In addition, a new program environment for the validation of computer-assisted diagnosis of melanoma, is briefly discussed. Finally, results are presented on determining optimal coefficients for the well-known ABCD formula, useful for melanoma diagnosis.
Źródło:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2003, 7, 2; 289-293
1428-6394
Pojawia się w:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Multiple colon perforation as a fatal complication during treatment of metastatic melanoma with ipilimumab – case report
Autorzy:
Dilling, Paweł
Walczak, Jakub
Pikiel, Paweł
Kruszewski, Wiesław J.
Powiązania:
https://bibliotekanauki.pl/articles/1395708.pdf
Data publikacji:
2014-02-01
Wydawca:
Index Copernicus International
Tematy:
melanoma
ipilimumab
anti-CTLA4
complications
Opis:
Ipilimumab, an anticancer drug, is an anti-CTLA4 monoclonal antibody. It is used in treatment of disseminated melanoma. Therapy is associated with high risk of complications. One of the most serious, although one of the rarest is perforation of gastrointestinal tract. In this case report we describe a 52-year old male, with disseminated melanoma with unknown starting point, treated with anti- CTLA4 monoclonal antibody. After 3rd dose of drug administration, bloody diarrhea and acute abdominal pain occurred as a symptom of gastrointestinal perforation. A single perforation was sutured during laparotomy. Symptoms of acute abdomen returned after 10 days. Pus-faecalperitonitis, symptoms of necro-hemorrhagic colitis and multilocal perforation of the colon were found during relaparotomy. Pancolectomy with end ileostomy was performed. Few hours since relaparotomy pacient died due to multiple organ failure. The purpose of this case report is to draw attention to a risk of multilocal colon perforation in patient treated with ipilumumab.
Źródło:
Polish Journal of Surgery; 2014, 86, 2; 94-96
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Melanoma of Unknown Primary as a Cause of Intestinal Obstruction - a Case Description
Autorzy:
Murawa, Dawid
Spychała, Arkadiusz
Powiązania:
https://bibliotekanauki.pl/articles/1396636.pdf
Data publikacji:
2012-08-01
Wydawca:
Index Copernicus International
Tematy:
melanoma of unknown primary
intestinal obstruction
Opis:
Melanoma of unknown primary applies to 1-8% of all diagnosed melanomas, whereas primary melanoma of the small intestine is a extremely rare case. One of the melanoma characteristics is its capability of forming metastases in the small intestine which very often are diagnosed during autopsy.We present a case report of diagnosed melanoma of unknown primary, whose first symptom was intestinal obstruction. Before admission to the hospital cause of intestinal obstruction, the patient didn't present any signs and symptoms. All typical localizations of primary melanoma were excluded during diagnostic procedure. Palliative right hemicolectomy and segmental small intestine resection were performed. There were no complications in the postoperative course. On the ninth day the patient was discharged from hospital.Quick identification and radical resection of melanoma metastases in the alimentary tract may improve the survival rate in this group of patients. Resection, even if it is palliative by assumption, is not only the best method of elimination of persistent symptoms but it also gives hope for longer survival.
Źródło:
Polish Journal of Surgery; 2012, 84, 8; 415-419
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Iris melanoma in a Labrador Retriever
Melanocytoma tęczówki u psa rasy labrador retriever
Autorzy:
Kanemaki, N.
Powiązania:
https://bibliotekanauki.pl/articles/9873.pdf
Data publikacji:
2013
Wydawca:
Okulistyka Weterynaryjna
Tematy:
iris
melanoma
dog
Labrador retriever dog
eye
ocular melanoma
tumour
animal disease
eye-ball
veterinary medicine
Opis:
U psów stosunkowo często spotykamy w gałce ocznej czerniaki. W przeciwieństwie do czerniaków występujących u kotów, u psów rzadko dają one przerzuty. Wczesne wykrycie tego typu zmian w oku zapobiega dalszym komplikacjom. Praca ta przedstawia przypadek czerniaka tęczówki u psa rasy labrador retriever. Początkowo zmianę tęczówki leczono steroidami i antybiotykami. Lecz leczenie to nie przyniosło oczekiwanych rezultatów. Dalsze diagnozowanie (ultrasonografia, gonioskopia) wykazało, że jest to czerniak. Wykonano resekcję części tęczówki. Siedem tygodni po resekcji zmiany, powrócił odruch źreniczny i widzenie. Badanie histopatologiczne wykazało, że usunięta zmiana to melanocytoma.
Źródło:
Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii; 2013, 1
2082-9256
Pojawia się w:
Okulistyka Weterynaryjna. e-kwartalnik dla lekarzy i studentów weterynarii
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Towards understanding the role of sialylation in melanoma progression
Autorzy:
Kolasińska, Ewa
Przybyło, Małgorzata
Janik, Marcelina
Lityńska, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1038776.pdf
Data publikacji:
2016
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
integrins
lectins
melanoma
progression
sialic acids
sialylation
Opis:
Aberrant expression of sialic acids or altered linkage types is closely associated with malignant phenotype and metastatic potential, and can have prognostic significance in human cancer. The present study was undertaken to evaluate whether expression of sialylated derivatives on melanoma cell surface is associated with tumour progression. Four cell lines (WM1552C, WM115, IGR-39 and WM266-4) were used in the study. Cell surface expression of sialic acids was evaluated by flow cytometry with the use of Maackia amurensis and Sambucus nigra lectins. Moreover, adhesion and migration potential of melanoma cells and involvement of sialic acids in these processes were analysed. We have demonstrated that WM266-4 cells have a significantly higher level of α2,3-linked sialic acid residues than other cells, whereas IGR-39 cells had lower expression of α2,6-linked sialic acids. The adhesion efficiencies of WM1552C and WM115 cells were significantly lower than that of IGR-39 and WM266-4 cells. In contrast, WM266-4 cells repaired scratch wounds at least twice as fast as other cells. Melanoma cell adhesion to fibronectin in the presence of Sambucus nigra agglutinin (SNA) was reduced only in IGR-39 and WM266-4 cells, whereas the impact of Maackia amurensis agglutinin (MAA) on this process was much more important. Migration efficiency of melanoma cells was reduced more strongly in the presence of MAA than SNA. In conclusion, our results show that melanoma progression is associated with the increased expression of α2,3-linked sialic acids on the cell surface and these residues could promote melanoma cell interaction with fibronectin.
Źródło:
Acta Biochimica Polonica; 2016, 63, 3; 533-541
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Monitoring vital functions of A-375 melanoma cell cultures via thin-film nickel capacitors
Autorzy:
Wilczyńska, Aleksandra
Kociubiński, Andrzej
Zarzeczny, Dawid
Szypulski, Maciej
Pigoń, Dominika
Małecka-Massalska, Teresa
Prendecka-Wróbel, Monika
Powiązania:
https://bibliotekanauki.pl/articles/1844972.pdf
Data publikacji:
2020
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
ECIS
nickel
thin layers
melanoma
magnetron sputtering
Opis:
This article deals in the constantly developing branch of microelectronic devices used in various fields of medicine, i.e. diagnostics and treatment of previously incurable human diseases. A method for assessing and monitoring the vital functions of living cells by measuring cellular impedance in real-time using the ECIS® system and a commercial culture substrate is presented. The goal was to develop a substrate significantly less expensive than a commercial substrate that would be suitable for multiple uses and compatible with the ECIS® measurement station. Moreover, thanks to the use of a material with electrochemical properties other than the biocompatible material (gold or platinum) it is possible to observe the cells behavior with regard to the toxic agent. For this purpose, a culture substrate with nickel comb capacitors was used. To make the electrodes, a thin metal layer was sputtered on polycarbonate plates in the magnetron sputtering process. Prior to the next stages, technological masks were designed so as to fit in the ECIS® measuring station. Subsequently, the microelectronic processes of photolithography and etching the metal layer were performed. Finally, the wells were glued onto the culture medium with a biocompatible adhesive. The completed substrates were transferred to the Department of Human Physiology, Medical University of Lublin, for the culture test on A-375 human melanoma cells. The results of the experiment determined the usefulness of the device for monitoring cell culture vital functions by means of impedance measurement.
Źródło:
Engineering of Biomaterials; 2020, 23, 157; 10-14
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
BRAF/MEK inhibitors in the systemic treatment of advanced skin melanoma
Autorzy:
Kruczała, Maksymilian
Grela-Wojewoda, Aleksandra
Ziobro, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1062946.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
BRAF inhibitors
MEK inhibitors
melanoma
targeted therapy
Opis:
A major progress has been made in the systemic treatment of advanced melanoma over the last few years. Targeted therapy has proven highly active, which is reflected in the response rate as well as progression-free survival and overall survival times. The paper aims to summarize the current knowledge on the available BRAF and MEK inhibitors.
Źródło:
OncoReview; 2017, 7, 3; 139-143
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sztuczne źródła promieniowania słonecznego jako czynnik ryzyka nowotworów skóry
Artificial solar radiation as a risk factor for skin tumor
Autorzy:
Woźniak-Holecka, Joanna
Holecki, Tomasz
Rokicka, Urszula
Powiązania:
https://bibliotekanauki.pl/articles/1039992.pdf
Data publikacji:
2009
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
promieniowanie ultrafi oletowe
sztuczne źródła promieniowania
nowotwory skóry
czerniak złośliwy (melanoma malignum)
edukacja zdrowotna
czynnik ryzyka
uv radiation
skin tumor
malignant melanoma (melanoma malignum)
health education
risk
factor
Opis:
Up to the ’70 one noticed mainly positive influence of solar radiation, and its component UV radiation. Only in next decade solar radiation was recognized as a main cause of many pathological skin changes, herein malicious tumor. At the same time there was a belief that using sun bathing beds is safe in relation to solar radiation. Nowadays in many countries it is recommended to popularize knowledge about the dangers of solariums, especially among youth. United States and Germany implemented restrictions forbidding under aged using sun beds without parental consent. Great Britain or Sweden are planning similar restrictions. Due to the latest scientific research published by the Lancet Oncology, starting using solarium sun bathing under 30 increases the skin cancer probability up to 70%. It was also proved that every solar radiation is carcinogenic, even though previously only UV-UVB was thought as carcinogenic.
Do lat 70-tych XX wieku dostrzegano głównie pozytywne aspekty oddziaływania promieniowania słonecznego, w tym i jego składowej - promieniowania ultrafi oletowego (UV) na zdrowie, propagowano właściwości przeciwkrzywicze światła słonecznego w kontekście roli jaką odgrywa w produkcji witaminy D3. Dopiero w następnym dziesięcioleciu promieniowanie słoneczne zostało uznane za czynnik sprawczy wielu zmian patologicznych w obrębie skóry, w tym nowotworów złośliwych. Jednocześnie uznawano, iż korzystanie z łóżek opalających jest bezpieczne w relacji do promieniowania słonecznego. Obecnie w wielu krajach zaleca się upowszechnianie wiedzy o potencjalnym niebezpieczeństwie opalania w solariach, zwłaszcza wśród młodzieży. W Stanach Zjednoczonych i Niemczech już wprowadzono restrykcyjne zakazy uniemożliwiające korzystanie z łóżek opalających przez młodzież do 18 roku życia, bez zgody opiekunów. Podobne obostrzenia są planowane w innych krajach np. Wielkiej Brytanii, Szwecji. W świetle najnowszych doniesień naukowych opublikowanych w Lancet Oncology szacuje się iż u osób, które zaczynają korzystać z solarium przed ukończeniem 30-go roku życia, ryzyko zachorowania na raka skóry wzrasta do 70%. Wykazano ponadto, że wszystkie typy promieniowania ultrafioletowego są rakotwórcze, podczas gdy dotąd sądzono, że niebezpieczny jest tylko jeden typ promieniowania UV – UVB.
Źródło:
Annales Academiae Medicae Silesiensis; 2009, 63, 6; 75-80
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Research on melanocitic skin lesion infobase enlargment - new facts and concepts
Autorzy:
Chrzanowska, D.
Niemiec, R.
Hippe, Z.
Powiązania:
https://bibliotekanauki.pl/articles/1940553.pdf
Data publikacji:
2017
Wydawca:
Politechnika Gdańska
Tematy:
melanoma
ABK
attributes importance
znamiona melanocytowe
znaczenie atrybutów
Opis:
The melanocytic skin lesion infobase, available at http://synthesis.melanoma.pl (also http://synteza.melanoma.pl, in Polish; referred to as INP) is currently undergoing a complete modification of the way in which (i) the internal synthesis algorithms and (ii) the classification of lesions are performed. We investigated 29 new real images of melanocytic skin lesions, focusing on how humans perform classification based on experience. In conclusion we suggest to add a new color – connected with the depth of a lesion – to the K term of Asymmetry (A),Border (B) and linear Combination of colors and structures (K) method (referred to as ABK).
Źródło:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk; 2017, 21, 4; 391-393
1428-6394
Pojawia się w:
TASK Quarterly. Scientific Bulletin of Academic Computer Centre in Gdansk
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of p16 in sporadic primary uveal melanoma.
Autorzy:
Lamperska, Katarzyna
Mackiewicz, Krystyna
Kaczmarek, Aldona
Kwiatkowska, Eliza
Starzycka, Maria
Romanowska, Bożena
Heizman, Janina
Stachura, Jerzy
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043765.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
sporadic primary uveal melanoma
mutations
p16 protein
Opis:
Expression of p16 protein, intragenic mutations of CDKN2A and hypermethylation of CDKN2A promoter region in 41 sporadic primary uveal melanomas were studied. There were 2 cases of spindle cell B histological type, 11 of A + B and 28 of mixed type. All melanomas infiltrated sclera but in 28 cases infiltration was superficial while in 13 profound. In 7 cases the tumor infiltrated the optic nerve. Expression of p16 was studied by immunohistochemistry and recorded by assessment of the proportion of positive tumor cells and staining intensity. Results were expressed as staining index (IRS). Intragenic mutations were studied by PCR-SSCP followed by sequencing, while hypermethylation of the promoter region by CpG methylation assay. In 15% of cases less than 10% of melanoma cells were p16 positive, in 70% of cases less than 50% of cells, while in 7% more than 80% of cells stained for p16 (mean IRS for all cases was 4.87 ± 2.43). In B type the IRS was 8.5 ± 0.7, in A + B type 6.0 ± 2.1 and in the mixed type 4.17 ± 2.43 (differences statistically significant). In melanomas profoundly infiltrating sclera mean IRS was 4.16, while in those infiltrating optic nerve 3.71 (statistically not significant). Analysis of the intragenic mutations revealed in two patients a GAC/GAT substitution in codon 84 - a silent mutation. No hypermethylation of the CpG island of the p16 promoter region was found. In conclusion, we found that the degree of p16 expression is related to the histological type of tumor but not to the histological indicators of tumor invasiveness and that intragenic mutations and promoter hypermethylation are not major mechanisms of p16 inactivation in sporadic uveal melanoma.
Źródło:
Acta Biochimica Polonica; 2002, 49, 2; 377-385
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of artificial neural networks in preliminary selection of pigmented lesions for further melanoma diagnosis
Autorzy:
Kisielińska-Ptasznik, Anna
Figielska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1397478.pdf
Data publikacji:
2020
Wydawca:
Warszawska Wyższa Szkoła Informatyki
Tematy:
artificial neural network
data pre-processing
melanoma diagnosis
Opis:
The paper deals with the problem of preliminary selection of pigmented lesionsfor further melanoma diagnosis. Several algorithms for input data pre-processingare proposed and artificial neural network for the examination of pigmented lesions is used. Computational results are reported.
Źródło:
Zeszyty Naukowe Warszawskiej Wyższej Szkoły Informatyki; 2020, 14, 22; 23-38
1896-396X
2082-8349
Pojawia się w:
Zeszyty Naukowe Warszawskiej Wyższej Szkoły Informatyki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Skin Lesion Analysis Toward Melanoma Detection Using Deep Learning Techniques
Autorzy:
Sherif, Fatma
Mohamed, Wael A.
Mohra, A.S.
Powiązania:
https://bibliotekanauki.pl/articles/226719.pdf
Data publikacji:
2019
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
melanoma
skin cancer
convolutional neural network
deep learning
Opis:
In the last few years, a great attention was paid to the deep learning Techniques used for image analysis because of their ability to use machine learning techniques to transform input data into high level presentation. For the sake of accurate diagnosis, the medical field has a steadily growing interest in such technology especially in the diagnosis of melanoma. These deep learning networks work through making coarse segmentation, conventional filters and pooling layers. However, this segmentation of the skin lesions results in image of lower resolution than the original skin image. In this paper, we present deep learning based approaches to solve the problems in skin lesion analysis using a dermoscopic image containing skin tumor. The proposed models are trained and evaluated on standard benchmark datasets from the International Skin Imaging Collaboration (ISIC) 2018 Challenge. The proposed method achieves an accuracy of 96.67% for the validation set. The experimental tests carried out on a clinical dataset show that the classification performance using deep learning-based features performs better than the state-of-the-art techniques.
Źródło:
International Journal of Electronics and Telecommunications; 2019, 65, 4; 597-602
2300-1933
Pojawia się w:
International Journal of Electronics and Telecommunications
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dual, enzymatic and non-enzymatic, function of ecto-5-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells
Autorzy:
Sadej, Rafal
Skladanowski, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1039675.pdf
Data publikacji:
2012
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
migration
melanoma
tenascin C
invasion
ecto-5'-nucleotidase
Opis:
Ecto-5'-nucleotidase (eN, CD73) mediates extracellular adenosine production from 5'-AMP. Non-enzymatic functions of eN have also been reported. The aim of the study was to investigate the role of ecto-5'-nucleotidase in aggressive melanoma behaviour. Analysis of the involvement of eN in adhesion, migration and invasion revealed eN functions unknown to date. We found that following eN blockade by concanavalin A, the strength of adhesion to different ECM proteins was not altered, but at the same time the invasion ability of the cells was decreased. On the other hand, knocking down eN in melanoma cells did not influence cell invasion but abolished their migration on tenascin C (TnC). Ecto-5'-nucleotidase seems to fulfil a more distinct role as a receptor than as an enzyme in the cell interaction and mobility on TnC. Ecto-5'-nucleotidase activates also focal adhesion kinase and enhances the formation of complexes upon cell adhesion to TnC. All these observations prove that an eN-TnC complex is involved in cell migration and invasion and thus in the regulation of melanoma progression.
Źródło:
Acta Biochimica Polonica; 2012, 59, 4; 647-652
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Malignant melanoma of the nasal cavity mucous membrane – two cases report
Autorzy:
Krawczyk, Przemysław
Kaczmarczyk, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/1401748.pdf
Data publikacji:
2016
Wydawca:
Index Copernicus International
Tematy:
malignant melanoma
mucous membrane
nasal cavity
paranasal sinuses
Opis:
Malignant melanoma is highly aggressive type of malignant neoplasm. The skin of the head and neck region is common localisation for appearance of this tumour due to exposition to the sun light. However, some number of cases concern development of the malignant melanoma on the mucous membranes. Most common signs are epistaxis and nasal obstruction. Late diagnosis effects with poor clinical prognosis. In our case, despite complete surgical resection and adjuvant therapy, outcome of the treatment was unsatisfying, because of metastasis and local recurrence.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2016, 5, 3; 33-37
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metastasis inhibition after proton beam, β- and γ-irradiation of melanoma growing in the hamster eye
Autorzy:
Romanowska-Dixon, Bożena
Elas, Martyna
Swakoń, Jan
Sowa, Urszula
Ptaszkiewicz, Marta
Szczygieł, Małgorzata
Krzykawska, Martyna
Olko, Paweł
Urbańska, Krystyna
Powiązania:
https://bibliotekanauki.pl/articles/1039523.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
metastases
melanoma
ocular
proton beam
iodine-125
ruthenium-106
Opis:
Standard ocular tumor treatment includes brachytherapy, as well as proton therapy, particularly for large melanoma tumors. However, the effects of different radiation types on the metastatic spread is not clear. We aimed at comparing ruthenium (106Ru, emitting β electrons) and iodine (125I, γ-radiation) brachytherapy and proton beam therapy of melanoma implanted into the hamster eye on development of spontaneous lung metastases. Tumors of Bomirski Hamster Melanoma (BHM) implanted into the anterior chamber of the hamster eye grew aggressively and completely filled the anterior chamber within 8-10 days. Metastases, mainly in the lung, were found in 100% of untreated animals 30 days after enucleation. Tumors were irradiated at a dose of 3-10 Gy with a 106Ru plaque and at a dose of 6-14 Gy using a 125I plaque. The protons were accelerated using the AIC-144 isochronous cyclotron operating at 60 MeV. BHM tumors located in the anterior chamber of the eye were irradiated with 10 Gy, for the depth of 3.88 mm. All radiation types caused inhibition of tumor growth by about 10 days. An increase in the number of metastases was observed for 3 Gy of β-irradiation, whereas at 10 Gy an inhibition of metastasis was found. γ-radiation reduced the metastatic mass at all applied doses, and proton beam therapy at 10 Gy also inhibited the metastastic spread. These results are discussed in the context of recent clinical and molecular data on radiation effects on metastasis.
Źródło:
Acta Biochimica Polonica; 2013, 60, 3; 307-311
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The CDKN2a common variants: 148 Ala/Thr and 500 C/G in 3 UTR, and their association with clinical course of melanoma
Autorzy:
Lamperska, Katarzyna
Przybyła, Anna
Kycler, Witold
Mackiewicz, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1041123.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
melanoma
statistical analysis
CDKN2a polymorphisms
3' UTR
Opis:
Changes in CDKN2a gene are known to be linked with sporadic melanoma and hereditary predisposition to this cancer. In the Polish population mutations in the coding region of the CDKN2a gene are rather rare, therefore the attention has been focused on polymorphisms and alterations in uncoding regions such as 3' UTR. The aim of this study was to analyze two common polymorphisms, Ala148Thr and 500 C/G, and correlate them with the clinical course of melanoma. DNA from 285 patients was analyzed and found polymorphisms were correlated with the clinical parameters employing statistical methods. The obtained results allow us to conclude: (i) survival times of 500 C/G carriers vs. cumulating proportion surviving was not statistically significant; (ii) CDKN2a polymorphism 500 C/G correlated with Ala148Thr; (iii) no correlation was observed between the 500 C/G polymorphism and age of diagnosis, localization of primary melanoma and survival time; (iv) we did not find correlation between 500 C/G and type of cancer in the family; (v) changes in the CDKN2a gene were not found in patients with second cancer.
Źródło:
Acta Biochimica Polonica; 2007, 54, 1; 119-124
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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