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Tytuł:
Intensional profiles and different kinds of human minds. “Case studies” about Hungarian imperative-like sentence types
Autorzy:
Alberti, Gábor
Kleiber, Judit
Schnell, Zsuzsanna
Szabó, Veronika
Powiązania:
https://bibliotekanauki.pl/articles/1040189.pdf
Data publikacji:
2016-12-30
Wydawca:
Katolicki Uniwersytet Lubelski Jana Pawła II
Tematy:
discourse representation/markers
mind representation
dynamic pragmatics
autism
Opis:
The paper offers such description of some imperative-like sentence types in potential well-formed Hungarian utterances which includes a parallel representation of the linguistically encoded intensional profiles of the sentence types and actual information states in potential interlocutors’ minds. In our representational dynamic pragmasemantics framework ReALIS, we demonstrate the intensional profiles of the five basic and two “fine-tuned” sentence types as members of a system enabling addressers’ of utterances to express their beliefs, desires and intentions concerning the propositional content of the given utterances as well as the addressees’ and other people’s certain beliefs, desires and intentions (concerning the propositional content, too, or each other’s thoughts). We also provide “case studies” in which actual beliefs, desires and intentions in potential interlocutors’ minds are compared to the linguistically encoded intensional profiles of Hungarian imperative-like sentence types. In this context, the listener’s task is to calculate the speaker’s intentions (and hidden motives) on the basis of the mismatches that this comparison reveals. The paper concludes with an insight into our attempts to model the mind of individuals living with Autism Spectrum Disorder. This latter subproject is relevant since our framework provides solutions to pragmaticosemantic phenomena “at the cost” of undertaking the complex task of actually representing the structure of the human mind itself – which is not impossible but requires an adequate decision of the level of abstraction and the components to be used.
Źródło:
Linguistics Beyond and Within; 2016, 2; 6-26
2450-5188
Pojawia się w:
Linguistics Beyond and Within
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
β-Glucan-Mediated Alleviation of NaCl Stress in Ocimum basilicum L. in Relation to the Response of Antioxidant Enzymes and Assessment DNA Marker
Autorzy:
Alhasnawi, Arshad Naji
Powiązania:
https://bibliotekanauki.pl/articles/124951.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Inżynierii Ekologicznej
Tematy:
NaCl-stress
beta-glucan
antioxidants
molecular markers
DNA variations
genetic stability
Opis:
Salinity is one of the most important abiotic stresses which can negatively affect the plant metabolic processes in the world. This can impact the plant production, either for economic or sustenance benefits. The salinity stress can cause many physiological and biochemical changes in the plants. β-glucans are important polysaccharides, which are present in the cell walls of various cereal grains. They protect the plant responses and occur in plant suspensions. In this study, the researchers attempted to investigate various physiological mechanisms and determine the role of the β-glucans in the NaCl-mediated stress conditions on the Ocimum basilicum L. seedlings. For this purpose, they carried out an experiment for assessing various shoot and root parameters along with the antioxidant enzyme activities, proline levels and the ISSR markers. When the seedlings were exposed to the NaCl stress conditions, they showed a significant decrease in the growth parameters and an increase in the antioxidant and proline levels compared to the control seedlings grown under normal saline conditions. On the other hand, the β-glucantreated seeds, when grown under the saline stress conditions, showed better growth parameters as well as high antioxidant enzyme activities and proline levels, compared to the control and NaCl-treated plants. Furthermore, a PCR analysis was carried out using the ISSR-marker technology, which could help in evaluating the DNA fingerprints and genetic variations in the plants. The results indicated that the exogenous application of the β-glucans could protect the antioxidant enzyme activities and protect the plants against the salinity stresses, without affecting the DNA-markers without affecting the genetic variations and could be a better choice for use in DNA-markers.
Źródło:
Journal of Ecological Engineering; 2019, 20, 8; 90-99
2299-8993
Pojawia się w:
Journal of Ecological Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Особенности грузинской языковой картины мира в свете межкультурной коммуникации
Autorzy:
Aroshidze, Nino
Powiązania:
https://bibliotekanauki.pl/articles/1052493.pdf
Data publikacji:
2019-12-15
Wydawca:
Wyższa Szkoła Gospodarki w Bydgoszczy. Wydawnictwo Uczelniane
Tematy:
georgian linguistic world image
cultural concepts
cross-cultural communication
linguistic and cultural code
translation challenges
language markers of the modern global
cultural space
Opis:
The article reviews specific features of the Georgian linguistic world image shaped during the long period of its existence. The analysis covers the cultural concepts and language markers that reflect the national characteristics. Being a special kind of cross-cultural communication, translation is a process of overcoming the linguistic and cultural barriers, and includes transcoding of language code as well as the cultural one. On the one hand, it uncovers the discrepancies between the key concepts in different cultures, and on the other hand, it demonstrates existence of the similar language markers of the ‘global cultural space’ that is being formed.
Źródło:
Heteroglossia- studia kulturoznawczo-filologiczne; 2019, 9; 169-179
2084-1302
Pojawia się w:
Heteroglossia- studia kulturoznawczo-filologiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Formulaic Sequences and Meta-Discourse Markers in Applied Linguistics Research Papers. A cross-linguistic corpus-based analysis of native and non- native authors’ published articles
Autorzy:
Assassi, Tarek
Merghmi, Kenza
Powiązania:
https://bibliotekanauki.pl/articles/2158862.pdf
Data publikacji:
2023-01-05
Wydawca:
Academicus. International Scientific Journal publishing house
Tematy:
metadiscourse markers
formulaic language
academic writing
cross-linguistic
Hyland’s classification
Opis:
Metadiscourse markers and their importance to academic writing are essential research subjects nowadays. The current corpus-based study aims at identifying interactional and interactive metadiscourse markers in terms of frequency and function in the abstract section of published research articles in applied linguistics developed by Algerian, Saudi, and Native researchers. 20 research articles for each group, with a total of 60 articles have been randomly selected and compiled as the research corpus for this study, then analyzed qualitatively and quantitatively using AntConc.3.2.4 relying on Hyland’s classification of metadiscourse markers. As a comparative study, the research considered the abstracts written by natives as a benchmark and attempted to find an answer to the main inquiry related to the frequency of use of metadiscourse devices by Algerian and Saudi researchers in comparison to their Native counterparts. The main research results showed how close were Algerian abstracts to native ones in terms of using endophorics, frame markers, code glosses, hedges, attitude markers, and self-mentions. While Saudi abstracts were close to the benchmark only in two markers that are transitions and engagement markers. The rest of the devices were shown to be far from the native norm in both cases. The findings also revealed that the use of metadiscourse markers is not the only indicator of papers’ publication rate in indexed journals by comparing the corpus analysis results to the source of the articles (journals), to find that even if Algerian researchers publish less in high indexed journals in comparison to Saudis, they are still closer in using markers to the natives as a benchmark.
Źródło:
Academicus International Scientific Journal; 2023, 14, 27; 154-175
2079-3715
2309-1088
Pojawia się w:
Academicus International Scientific Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of neutrophil phagocytic, complement functions, and cytokines expression among diabetic patients in Abuja, Nigeria
Autorzy:
Babandina, Musa Muhammad
Mainasara, Abdullahi Suleiman
Bakare, Mustapha
Emeribe, Anthony Uchenna
Shuwa, Halima Ali
Haruna, Shamsuddeen
Muhammad, Aminu Said
Abdullahi, Idris Nasir
Powiązania:
https://bibliotekanauki.pl/articles/454973.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
diabetes mellitus
effector molecules
pro-inflammatory markers
Opis:
Introduction. Inflammatory response in Diabetes Mellitus (DM) begins with chronic sub-clinical inflammations as a result of insulin resistance and activation of both innate and adaptive immune system as the disease progresses to complicated diabetes. Hence, the present study investigated the neutrophil phagocytic, complement function (CH50), and some cytokine profiles among diabetic and non-diabetic patients attending the National Hospital in Abuja, Nigeria. Aim. To evaluate the neutrophil phagocytic, complement function (CH50), and some cytokine profiles among post-operative septic diabetic and post-operative septic non-diabetic patients at the National Hospital in Abuja, Nigeria. Material and methods. Subjects were recruited by convenient sampling technique through interviewer-administered questionnaires. Subsequently, blood samples were collected. Fasting blood sugar (FBS) (mmol/L) was determined using glucose oxidase method. Neutrophil function test (Fmol/phag) was assayed using nitroblue tetrazolium reduction test (NBT). Hemolytic complement function (CH 50) test was conducted using serum harvested from sheep sensitized with human group (ORh D +ve) red blood cells. While serum Interleukin-4, -6, -10 and TNF- α were determined using Enzyme Linked Immunosorbent Assay (ELISA). Results. Mean ± Standard deviation (SD) of FBS concentration of 10.5 ± 1.3 (mmol/|L) among diabetic and 4.7 ± 0.9 (mmol/L) among non-diabetics was recorded. There is a decrease in neutrophil phagocytic function with a mean ± SD of 5.4 ± 2.1 (Fmol/ phag) in diabetics compared to 9.2 ± 2.1 (Fmol/phag) in non-diabetics. Similarly, complement (CH 50) function and C-reactive protein were significantly lower in diabetics when compared to non-diabetics (p<0.001). There was a significant difference in IL-6 concentration between diabetics and non-diabetics groups, but no significant difference was observed in TNF-α, IL-4 and IL-10 concentrations between study groups (p>0.05). TNF-α and IL-6 was significantly higher in diabetics with cardiovascular disorders compared to non-diabetics subjects with cardiovascular disorders (p<0.001). Conclusion. Findings from this study revealed the association of complement, neutrophil phagocytic function, CRP and IL-6 among septic diabetic patients,. In addition TNF-α and IL-6 expression was higher in DM patients with cardiovascular disorders.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 229-235
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spektrometria mas w analizie białek i peptydów : znaczniki jonizacyjne
Mass spectrometry in analysis of peptides and proteins : ionization markers
Autorzy:
Bąchor, R.
Biernat, M.
Cebrat, M.
Kijewska, M.
Kluczyk, A.
Kuczer, M.
Paluch, A.
Waliczek, M.
Wierzbicka, M.
Stefanowicz, P.
Szewczuk, Z.
Powiązania:
https://bibliotekanauki.pl/articles/171509.pdf
Data publikacji:
2018
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
spektrometria mas
modyfikacje potranslacyjne
znaczniki jonizacyjne
fosforylacja
glikacja
biblioteki kombinatoryczne
mass spectrometry
post-translational modifications
ionization markers
phosphorylation
glycation
combinatorial libraries
Opis:
High sensitivity, accuracy, and ability to provide structural information makes mass spectrometry (MS) the method of choice for both qualitative and quantitative analysis in proteome research. Peptide sequencing by tandem mass spectrometry (MS/MS) was successfully applied to discover new peptide sequences and modifications. Insufficient ionization of some peptides is one of the main limitations of MS- based peptide identification. The development of sensitive detection techniques for the efficient analysis of such samples is very important. Differences in ionizability cause difficulties in quantification studies, which could be overcome by derivatization of peptides to improve both the detectability and the selectivity of an analysis. Incorporation of ionization markers and isotopic labels (particularly the isobaric tags) is often used for this reason. Isobaric labeling reagents (including commercially available iTRAQ, TMT, DiLeu and DiART) have found a wide application in quantitative proteomics. Mass spectrometry is a very good tool for the determination of posttranslational modifications (PTMs), but the modified proteins are usually present in low concentrations. The development of ionization tags specific to a particular PTM and suitable for sensitive analysis of the modified proteins is required. For the analysis of phosphorylated peptides, a combination of β-elimination and the reaction of resulting α,β-dehydroamino acid residues with the nucleophilic thiol group could be used to detect a labile PTM. Such reaction may be used to introduce derivatizing reagents at the original site of phosphorylation, to enhance ionization in MS analysis. Glycation and glycosylation of proteins are other very important PTMs associated with many natural processes as well as diseases. We have designed and synthesized bifunctional quaternary ammonium salt derivatives of phenylboronic acids for selective detection of carbohydrates and peptide-derived Amadori products by ESI-MS. The attachment of a fixed charge (e.g. in a form of a quaternary ammonium salt) to the amino groups in peptides leads to the enhancement of a precursor ion signal in mass spectra. We have developed several new QAS-containing ionization reagents including bicyclic tags with DABCO, ABCO or azoniaspiro groups. It is worth noting that 2,4,6-substituted pyrylium salts react with amino groups in peptides introducing a stable positive charge and improve peptide detection by MS. The newly developed ionization tags were successfully applied for the analysis of OBOC combinatorial libraries as well as for studying possible biomarkers of preeclampsia, a pregnancy disorder.
Źródło:
Wiadomości Chemiczne; 2018, 72, 7-8; 609-633
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic variation of safflower (Carthamus tinctorius L.) and related species revealed by ISSR analysis
Autorzy:
Bagmohammadi, Hamed
Pahlevani, Mohammadhadi
Ahmadikhah, Asadollah
Razavi, Seyed Esmaeil
Powiązania:
https://bibliotekanauki.pl/articles/2199709.pdf
Data publikacji:
2012-08-20
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
Genetic diversity
ISSR markers
relationships
safflower
wild spices
Opis:
Genetic diversity of eight genotypes of Carthamus tinctorius L., two populations of C. oxyacanthus, and one population of C. lanatus was investigated using inter-simple sequence repeat (ISSR) markers. All samples were uniquely distinguished by 10 ISSR primers with 144 bands which generated 100% polymorphism. Furthermore, the ISSR markers could separate three safflower species properly, that highlights the effectiveness of this marker system for phylogenetic studies. The most and least informative primers were ISSR9 (PIC=0.367) and ISSR2 (PIC=0.254), and some primers were more efficient in detecting polymorphism in one species than for the others. Unweighed pairgroup method with arithmetical averages (UPGMA) cluster analysis enabled construction of a dendrogram  for estimating genetic distances among different populations. The result of cluster analysis suggested that cultivated and wild populations of C. oxyacanthus had close relationship with each other and far relationship with C. lanatus. The extreme genetic dissimilarity was observed between genotypes of C. tinctorius and C. lanatus populations. Based on the results, C. oxyacanthus could introduce favorable genes to cultivated safflower via inter-specific hybridization in breeding programs. Nei’s gene diversity index, Shannon’s index and percent of polymorphic loci showed that Isfahan ecotype of C. oxyacanthus had the highest variation at DNA level in relation to populations of other species. The ISSRs developed in this research along with those recently studied by other researchers will contribute to construct genetic map with a density sufficient for safflower molecular breeding.
Źródło:
Plant Breeding and Seed Science; 2012, 66; 139-150
1429-3862
2083-599X
Pojawia się w:
Plant Breeding and Seed Science
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
HISTORY OF THE DATIVE MARKERS IN KOREAN LANGUAGE: FROM OLD KOREAN TO CONTEMPORARY KOREAN
한국어 여격조사의 역사: 고대한국어에서부터 현대한국어까지
Historia sposobu wyrażania celownika w języku koreańskim: od starokoreańskiego do współczesnego koreańskiego
Autorzy:
BAILBLÉ, Olivier
Powiązania:
https://bibliotekanauki.pl/articles/1040346.pdf
Data publikacji:
2016-11-04
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:
Datives Markers
Early Middle Korean
Chinese Characters
Idu Writing System
Opis:
The focus of this paper and the intention of the author are to show in a diachronic perspective how the dative markers in Korean Language have changed and evolved during two thousand years of history. The rise of new writing systems during 8th century such as Idu and also the difference of the structure of the language between Chinese and Korean bring different conclusions. In particular, this paper will focus on the different grammatical origins of dative markers and additionally the morphological changes will be shown in those structures, especially with the rise of the Korean Alphabet in 15th century.
이 연구는 한국어 여격의 변화를 통시적 관점에서 다루고 있다. 이천 년 전 한국인들은 외국에서 온, 다시 말해 한자를 사용하기 시작하였다. 풍부하지 않은 자료로 첫 번째 여격의 초기형태를 엿보기 위해서는 5 세기 광개토대왕의 비문을 참고해야만 한다. 하지만 광개토왕의 비문의 글은중국어 문법에 따라 한자어로 쓰여 있어 문장에 대한 판독은 쉽지 않다. 바로 이러한 이유로 그 시대부터 한국사람들은 전통적인 한자어 구조를 한국어의 구조에 맞게 변경하기 시작하였다. 이러한 변화는 이두 표기법 (관료들의 문자) 의 출현에서 엿볼 수 있다. 이두 표기법은 고대의 텍스트에 존재하지 않은 한국어의 문법적인 형태를 재현해주고 있다. 게다가 12 세기경에는 우리는 이두 표기법의 여격에서 분명하게 이 변화를 알아볼 수 있다. 한편 이두 표기법은 훈민정음 창제로 또 다른 중요한 발전을 맞이하게 된다. 이두 표기법으로 표현된, 중국어의 차용으로 표기된 조사는 대다수 한글로 대체되어 사라지게 된 것이다. 여격 또한 이 변화에 예의 없이 원래의 기원과는 많이 달라진 형태를 보여준다. 유교사상의 결합으로 생긴 사회계층에 의한 높임말에 변화에 따라 여격의 변화가 생기는 것이다. 이러한 기원은 우리가 누구와 대화하느냐에 따라 다르게 표현되는 현대 한국어에서 쉽게 찾아볼 수 있다.
Źródło:
International Journal of Korean Humanities and Social Sciences; 2015, 1; 119-136
2449-7444
Pojawia się w:
International Journal of Korean Humanities and Social Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
La subjetivización y las dinámicas interaccionales
Subjectification and interactional dynamics
Autorzy:
Baran, Marek
Powiązania:
https://bibliotekanauki.pl/articles/1050939.pdf
Data publikacji:
2014-01-01
Wydawca:
Uniwersytet im. Adama Mickiewicza w Poznaniu
Tematy:
subjectification
pragmaticalization
interactional linguistics
conversational markers
ethnolects
Spanish language
face-work
Opis:
In the present article the subjectification process is being discussed in relation to the concept of interactional dynamics. It is suggested that to encode various semantic-pragmatic profiles can lead to changes at the level of communicative behavior patterns, which, for their part, are dominated by a particular order of socio-cultural conventionalization. The scope of conversational markers or nominal forms of address (NFA), which are submitted to analysis in the present study, indicates that the routinizing language use, together with an explicit grammatical manifestation, covers areas that appear to be semantically and pragmatically important in a given speaking community.
Źródło:
Studia Romanica Posnaniensia; 2014, 41, 1; 3-16
0137-2475
2084-4158
Pojawia się w:
Studia Romanica Posnaniensia
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Genetic diversity of Italian populations of Abies alba
Autorzy:
Belletti, Piero
Ferrazzini, Diana
Ducci, Fulvio
De Rogatis, Anna
Mucciarelli, Marco
Powiązania:
https://bibliotekanauki.pl/articles/956994.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Instytut Dendrologii PAN
Tematy:
silver fir
genetic differentiation
glacial refugia
regions of provenance
ssr markers
Opis:
Silver fir (Abies alba) is a common tree species in the mountainous areas in Europe. A number of natural stands in the hilly regions of northern Europe represent relic populations. The aim of the research was to evaluate the diversity present in Italian populations of the species. Genetic diversity was assessed in 45 silver fir populations covering the species’ distribution range in Italy, based on the allelic variation present at seven microsatellite loci (SSRs). A consistent level of intra-population variability was present. Several of the populations displayed signs of ongoing genetic erosion, and evidence for a recent bottleneck in some was identified. Populations from the eastern Alps and the Apennines were more variable than those sampled from the western Alps. About 8% of the overall genetic variance was found between populations, with the remainder representing variation present within the populations. The data suggested that the southern Apennines acted as a refugium during the most recent Ice Age, and that many of the populations from this area have remained isolated over a prolonged period. Smaller and more isolated populations have experienced genetic drift, whereas the larger ones have preserved a high level of diversity. Identification of genetically homogeneous regions could be informative for the management of genetic resources.
Źródło:
Dendrobiology; 2017, 77; 147-159
1641-1307
Pojawia się w:
Dendrobiology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analiza Sytemu Termoanemometru Falowego
Analysis of a Hot-Wire Anemometer System
Autorzy:
Biernacki, Z.
Powiązania:
https://bibliotekanauki.pl/articles/209121.pdf
Data publikacji:
2008
Wydawca:
Wojskowa Akademia Techniczna im. Jarosława Dąbrowskiego
Tematy:
termoanemometr falowy
znaczniki termiczne
medium przepływowe
hot-wire anemometer
thermal markers
flowing medium
Opis:
W pracy przedstawiono badania Systemu Termoanemometru Falowego (STF), opracowanego i zbudowanego na podstawie koncepcji autora. Pierwotna idea znaczników cieplnych, podana przez Kovaszyna, posłużyła do opracowania STF przeznaczonego do określania prędkości przepływu medium poprzez pomiar czasu przelotu tych znaczników, unoszonych przez badane medium przepływowe (np. gaz), na dokładnie ustalonym a priori odcinku, będącym charakterystycznym parametrem konstrukcyjnym sensora pomiarowego. Zakres badań obejmuje analizę modelu z wykorzystaniem symulacji komputerowych, jak również badania laboratoryjne. Praca koncentruje się głównie na użyciu adekwatnych metod matematycznych do analizy modelu.
The paper deals with investigation of a Hot-Wire Anemometer System developed and built on the basis of the author's own design idea. The Hot-Wire Anemometer System (STE) is based on Kovasznay's idea of measuring the transit time of thermal markers drifted by the flowing medium (e.g. gas) on the a priori known interval, which is a design constant of the measuring converter. The scope of invastigation includes model studies employing computer simulation techniques as well as experiments on a laboratory stand. The work is focused mainly on the model studies with the use of adequate mathematical methods.
Źródło:
Biuletyn Wojskowej Akademii Technicznej; 2008, 57, 2; 73-89
1234-5865
Pojawia się w:
Biuletyn Wojskowej Akademii Technicznej
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
La e-langue des jeunes en France et en Ukraine
The e-language of the young in France and in Ukraine
Autorzy:
Bilas, Andriy
Powiązania:
https://bibliotekanauki.pl/articles/676227.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
e-langue des jeunes
sociolecte
formes
marqueurs
typologie
universaux
youth e-language
sociolect
forms
markers
typology
universals
Opis:
The article proposes the comparative study of the new forms of youth’s slang induced by the development of communication via Internet and its impact on common communication and language. Our study also considers scientific literature examining e-language markers of French and Ukrainian youth striving for sociolinguistic cooperation under the analyzed sociolect circumstances. The multidisciplinary approach makes it possible to construct the typology of the youth’s e-language forms.
Le cadre de cet article est l’étude comparative des nouvelles formes de la langue des jeunes induites par le développement de la communication par Internet et son impact sur la communication et la langue communes. Notre étude s’appuie également sur toute une littérature qui cherche à penser les formes de la langue des jeunes à partir de l’analyse des marqueurs de la e-langue des jeunes en France et en Ukraine afin de dégager la cohérence sociolinguistique des universaux de ce sociolecte. Une approche pluridisciplinaire permet de construire une typologie des formes de la e-langue des jeunes.
Źródło:
e-Scripta Romanica; 2019, 7; 40-51
2392-0718
Pojawia się w:
e-Scripta Romanica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Current and potential oncomarkers in diagnosing breast cancer
Obecnie używane i potencjalne markery nowotworowe w diagnostyce raka piersi
Autorzy:
Bilecová-Rabajdová, M.
Urban, P.
Grešová, A.
Varga, J.
Gregová, K.
Stupák, M.
Mareková, M.
Powiązania:
https://bibliotekanauki.pl/articles/271594.pdf
Data publikacji:
2012
Wydawca:
Górnośląska Wyższa Szkoła Pedagogiczna im. Kardynała Augusta Hlonda
Tematy:
rak piersi
diagnostyka
markery molekularne
markery nowotworowe TVMs
breast cancer
diagnostics
molecular markers
tumour vascular markers
Opis:
Breast cancer is a very serious disease from both an economical and social point of view, because of its high incidence and mortality, as well as its prevalence. Genetic and epigenetic changes as well as the resultant deregulation of mechanisms that affect cellular processes are reflected in the final stage, like significant variability in phenotype. These changes have multiple factors in clinical, morphological but also molecular terms, and they greatly affect the possibility of accurate diagnosis of breast cancer in its early stages. Since no combination of clinical examination, mammography and ultrasonography together with CT and MRI can achieve 100% sensitivity, clinical practice is supported with diagnostic methods based on the monitoring of tumour markers with the emphasis on molecular markers. This review describes the most common molecular markers already used for earlier clinical diagnostics and also proposes new possible markers from the tumour vascular markers group. Any new oncomarkers to improve diagnostic sensitivity and specificity will be of great benefit, and in clinical practice, they may provide an opportunity for early diagnostic and therapeutic intervention, and subsequently better prognosis for the patient as well.
Rak piersi jest bardzo poważną chorobą, zarówno z punktu widzenia ekonomicznego jak i społecznego, ze względu na dużą zachorowalność i umieralność, a także na zakres jego występowania. Zmiany genetyczne i epigenetyczne, jak również wynikająca z nich deregulacja mechanizmów, które wpływają na procesy komórkowe są odzwierciedlone w ostatnim stadium choroby, jak znaczna zmienność fenotypu. Zmiany te mają wiele przyczyn z punktu widzenia klinicznego, morfologicznego, ale również molekularnego oraz znacznie wpływają na możliwość dokładnego rozpoznania raka piersi w jego wczesnych fazach. Ponieważ żadna kombinacja badań klinicznych, mammografii i USG wraz z tomografią komputerową i obrazowaniem magnetyczno-rezonansowym nie może osiągnąć 100% czułości, praktyka kliniczna jest wspierana metodami diagnostycznymi opartymi na monitoringu markerów nowotworowych, ze szczególnym uwzględnieniem markerów molekularnych. Niniejsza recenzja opisuje najbardziej typowe markery molekularne wykorzystywane we wczesnej diagnostyce klinicznej, a także proponuje nowe potencjalne markery z grupy markerów nowotworowych TVMs . Wszelkie nowe markery nowotworowe poprawiające czułość i dokładność diagnostyki będą bardzo pomocne, a w praktyce klinicznej mogą pozwolić na wczesną diagnostykę i leczenie, co polepszy także rokowania pacjenta.
Źródło:
Journal of Ecology and Health; 2012, R. 16, nr 3, 3; 138-143
2082-2634
Pojawia się w:
Journal of Ecology and Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of sodium fluoride on bone metabolism and structural changes of the mandible in ovariectomized rats
Wpływ fluorku sodu na metabolizm tkanki kostnej i zmiany strukturalne w żuchwach szczurów poddanych owariektormii
Autorzy:
Bohatyrewicz, A.
Wiechowska, M.
Machoy-Mokrzyńska, A.
Jurewicz, A.
Leźnicka, K.
Grocholewicz, K.
Karaczun, M.
Weyna, E.
Powiązania:
https://bibliotekanauki.pl/articles/135790.pdf
Data publikacji:
2018
Wydawca:
Wyższa Szkoła Techniczno-Ekonomiczna w Szczecinie
Tematy:
rats
ovariectomy
mandible
fluoride
bone remodelling markers
bone mineral content
szczury
wycięcie jajników
owareiektomia
żuchwa
fluorki
markery przebudowy kości
składniki mineralne kości
zawartość
Opis:
Introduction and aim: The role of fluorides in caries prevention is widely known, however, due to a large number of factors affecting the metabolism of bone tissue (e.g. estrogens), the evaluation of the effect of these compounds on the masticatory system requires comprehensive studies. The aim of the study was to examine the effect of fluorides on the chosen biochemical markers of bone remodelling, on the bone mass and structural changes in the lower jaw (mandible) of castrated rats, after six-week exposure to sodium fluoride in different doses. Material and methods: The experiment was conducted on an animal model using female Wistar rats divided into four groups: a control group and three research groups (ovariectomized and exposed to fluoride compounds in different doses in the drinking water). In order to evaluate the effect of estrogens shortage induced by double-sided ovariectomy and to analyze the fluorides influence on bone metabolism and structural changes of the mandible, tests of bone tissue metabolism markers, bone mineral content in the mandible, height of a molar tooth, height of alveolar appendix and index of rats' alveolar appendices heights were performed. Results: Ovariectomy procedure led to the appearance of higher concentrations of bone tissue resorption markers and lower mineral weight of mandible, but did not exert a considerable impact on mineral weight index in animals receiving fluorides. There was no statistical difference in the heights of molar teeth between all experimental groups. Conclusion: Eestrogens shortage, due to ovariectomy, reduces mineral weight of lower jaw bones and mineral weight index, and the fluoride supply prevents the loss of minerals from an osseous tissue.
Wstęp i cel pracy: Rola fluorków w profilaktyce próchnicy jest powszechnie znana, jednakże ze względu na dużą liczbę czynników wpływających na metabolizm tkanki kostnej (np. estrogeny), ocena wpływu tych związków na układ żucia wymaga kompleksowych badań. Celem tego badania było zbadanie wpływu fluorków na wybrane markery przebudowy kości, na masę kości i strukturalne zmiany w dolnej szczęce (żuchwie) kastrowanych szczurów po sześciotygodniowej ekspozycji na różne dawki fluorku sodu. Materiał i metody: Doświadczenie przeprowadzono na modelu zwierzęcym, w którym samice szczurów Wistar podzielono na cztery grupy: grupę kontrolną i trzy grupy badawcze (poddane owariektomii i eksponowane różne dawki związków fluoru podawanych w wodzie pitnej). Aby ocenić wpływ niedoboru estrogenów wywołanego obustronną owariektomią i aby przeanalizować wpływ fluorków na metabolizm kostny i zmiany strukturalne żuchwy, konieczne było przeprowadzenie badań markerów metabolizmu kostnego oraz zawartości związków mineralnych w kości żuchwy, a także dokonanie pomiarów wysokości zęba trzonowego, wysokości wyrostka zębodołowego i wskaźnika wysokości wyrostków zębodołowych u badanych szczurów. Wyniki: Na skutek przeprowadzonej owariektomii zaobserwowano wyższe stężenia markerów resorpcji tkanki kostnej oraz niższą masę mineralną kości szczęki dolnej. Zabieg ten jednak nie miał znaczącego wpływu na wskaźnik masy mineralnej u zwierząt otrzymujących fluorki. Nie stwierdzono statystycznej różnicy w wysokości zębów trzonowych pomiędzy grupami eksperymentalnymi. Wnioski: Niedobór estrogenów spowodowany wycięciem jajników prowadzi do obniżenia masy mineralnej kości żuchwy oraz wskaźnika masy mineralnej, a fluorki zapobiegają utracie minerałów z tkanki kostnej.
Źródło:
Problemy Nauk Stosowanych; 2018, 8; 137-146
2300-6110
Pojawia się w:
Problemy Nauk Stosowanych
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Charakterystyka wybranych markerów molekularnych
Characteristic of selected molecular markers
Autorzy:
Bolc, Paulina
Powiązania:
https://bibliotekanauki.pl/articles/2199379.pdf
Data publikacji:
2020-10-22
Wydawca:
Instytut Hodowli i Aklimatyzacji Roślin
Tematy:
markery molekularne
RFLP
AFLP
RAPD
SSR
ISSR
SRAP
SNP
PCR
polimorfizm
różnorodność genetyczna
molecular markers
polymorphism
genetic diversity
Opis:
Postęp, jaki nastąpił w biologii molekularnej poprzez wprowadzenie markerów molekularnych nowej generacji, w ciągu ostatnich 20 lat umożliwił znaczny rozwój wielu dziedzin badań. Możliwe stało się uzyskanie dokładniejszych informacji genetycznych pozwalających na lepsze zrozumienie zasobów genetycznych organizmów. Markerem molekularnym może być każda sekwencja nukleotydowa (wybrany fragment DNA), rozproszony w całym genomie, której zmienność między osobnikami lub grupami taksonomicznymi umożliwia precyzyjną identyfikację osobnika/taksonu. Kompilacja właściwości enzymów restrykcyjnych jak również reakcji łańcuchowej polimerazy (PCR) w technikach generujących markery molekularne pozwoliła na efektywne wykorzystanie ich w taksonomicznych, ewolucyjnych i ekologicznych badaniach roślin.
Over the last 20 years, the progress in molecular biology through the introduction of new generation molecular markers has allowed many areas to move forward. It has now become possible to obtain more accurate genetic information to better understand the genetic resources of organisms. A molecular marker can be any nucleotide sequence (selected DNA fragment) scattered throughout the genome, whose variability between individuals or taxonomic groups allows precise identification of the individual/taxon. The effectiveness of restriction digestion and polymerase chain reaction based on molecular markers has already proved their usefulness in taxonomic, evolutionary and ecological plant research.
Źródło:
Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin; 2020, 290; 27-32
0373-7837
2657-8913
Pojawia się w:
Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin
Dostawca treści:
Biblioteka Nauki
Artykuł
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