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    Wyświetlanie 1-6 z 6
    Tytuł:
    Kinetic analysis of LDL apoB transport and metabolism in non-steady states
    Autorzy:
    Weryński, A.
    Nahorski, Z.
    Angelin, B.
    Berglund, L.
    Eriksson, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/206021.pdf
    Data publikacji:
    2000
    Wydawca:
    Polska Akademia Nauk. Instytut Badań Systemowych PAN
    Tematy:
    biocybernetyka
    apheresis
    kinetic modelling
    low density lipoprotein (LDL)
    Opis:
    In this paper a novel kinetic analysis is used for evaluation of the low density lipoprotein (LDL) apoB fractional catabolic rate (FCR) after LDL apheresis which creates a nonsteady state. The formulae for calculation of FCR, and LDL rate of appearance (Ra) as functions of time have been derived. Calculations for one normal and one familial hypercholesterolemic (FH) subjects showed that FCR as well as Ra exhibited variations which can be attributed to the circadian rhythm in LDL metabolism. LDL apheresis had a little impact on both Ra and FCR in normal as well as in FH subjects. However, Ra in FH subject was found to be much higher than - that in the normal subject.
    Źródło:
    Control and Cybernetics; 2000, 29, 1; 405-425
    0324-8569
    Pojawia się w:
    Control and Cybernetics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The reactions of hypochlorous acid, the reactive oxygen species produced by myeloperoxidase, with lipids.
    Autorzy:
    Spickett, Corinne
    Jerlich, Andreas
    Panasenko, Oleg
    Arnhold, Juergen
    Pitt, Andrew
    Stelmaszyńska, Teresa
    Schaur, R.
    Powiązania:
    https://bibliotekanauki.pl/articles/1044206.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    lipid chlorohydrins
    lipids
    unsaturated fatty acids
    hypochlorous acid
    lipid peroxidation
    low density lipoprotein
    Opis:
    Myeloperoxidase (MPO), an abundant enzyme in phagocytes, has been implicated in the pathogenesis of various inflammatory diseases including atherosclerosis. The major oxidant produced by MPO, hypochlorous acid (HOCl), is able to modify a great variety of biomolecules by chlorination and/or oxidation. In this paper the reactions of lipids (preferentially unsaturated fatty acids and cholesterol) with either reagent HOCl or HOCl generated by the MPO-hydrogen peroxide-chloride system are reviewed. One of the major issues has been whether the reaction of HOCl with lipids of low density lipoprotein (LDL) yields predominantly chlorohydrins or lipid hydroperoxides. Electrospray mass spectrometry provided direct evidence that chlorohydrins rather than peroxides are the major products of HOCl- or MPO-treated LDL phosphatidylcholines. Nevertheless lipid peroxidation is a possible alternative reaction of HOCl with polyunsaturated fatty acids if an additional radical source such as pre-formed lipid hydroperoxides is available. In phospholipids carrying a primary amino group such as phosphatidylethanolamine chloramines are the preferred products compared to chlorohydrins. Cholesterol can be converted by HOCl to great variety of oxysterols besides three isomers of chlorohydrins. For the situation in vivo it appears that the type of reaction occurring between HOCl and lipids would very much depend on the circumstances, e.g. the pH and the presence of radical initiators. The biological effects of lipid chlorohydrins are not yet well understood. It has been shown that chlorohydrins of both unsaturated fatty acids as well as of cholesterol may cause lysis of target cells, possibly by disruption of membrane structures.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 4; 889-899
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Impact of diabetes-associated lipoproteins on oxygen consumption and mitochondrial enzymes in porcine aortic endothelial cells
    Autorzy:
    Xie, Xueping
    Chowdhury, Subir
    Sangle, Ganesh
    Shen, Garry
    Powiązania:
    https://bibliotekanauki.pl/articles/1040288.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    mitochondrial membrane potential
    mitochondrial oxygen
    respiration chain
    vascular endothelial cells
    consumption
    low density lipoprotein
    Opis:
    Impairments in mitochondrial function have been proposed to play an important role in the pathogenesis of diabetes. Atherosclerotic coronary artery disease (CAD) is the leading cause of mortality in diabetic patients. Mitochondrial dysfunction and increased production of reactive oxygen species (ROS) are associated with diabetes and CAD. Elevated levels of glycated low density lipoproteins (glyLDL) and oxidized LDL (oxLDL) were detected in patients with diabetes. Our previous studies demonstrated that oxLDL and glyLDL increased the generation of ROS and altered the activities of antioxidant enzymes in vascular endothelial cells (EC). The present study examined the effects of glyLDL and oxLDL on mitochondrial respiration, membrane potential and the activities and proteins of key enzymes in mitochondrial electron transport chain (mETC) in cultured porcine aortic EC (PAEC). The results demonstrated that glyLDL or oxLDL significantly reduced oxygen consumption in Complex I, II/III and IV of mETC in PAEC compared to LDL or vehicle control using oxygraphy. Incubation with glyLDL or oxLDL significantly reduced mitochondrial membrane potential, the activities of mitochondrial ETC enzymes - NADH dehydrogenase (Complex I), succinate cytochrome c reductase (Complex II + III), ubiquinol cytochrome c reductase (Complex III), and cytochrome c oxidase (Complex IV) in PAEC compared to LDL or control. Treatment with oxLDL or glyLDL reduced the abundance of subunits of Complex I, ND1 and ND6 in PAEC. However, the effects of oxLDL on mitochondrial activity and proteins were not significantly different from glyLDL. The findings suggest that the glyLDL or oxLDL impairs mitochondrial respiration, as a result from the reduction of the abundance of several key enzymes in mitochondria of vascular EC, which potentially may lead to oxidative stress in vascular EC, and the development of diabetic vascular complications.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 4; 393-398
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prostaglandins and arterial wall lipid metabolism - in vitro, ex-vivo and in vivo radioisotopic studies
    Autorzy:
    Sinzinger, H
    Rogatti, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/69328.pdf
    Data publikacji:
    1994
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    metabolism
    prostaglandin
    lipid
    calcium antagonist
    in vivo
    lipid metabolism
    radioisotopic study
    in vitro
    hypercholesterolemia
    low density lipoprotein
    atherosclerosis
    Źródło:
    Journal of Physiology and Pharmacology; 1994, 45, 1
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A long-term fish diet modifies the toxic properties of human partially oxidized LDL on vascular preparations in vitro
    Autorzy:
    Seppo, L.
    Karjala, K.
    Nevala, R.
    Korpela, R.
    Lahteenmaki, T.
    Solatunturi, E.
    Tikkanen, M.J.
    Vapaatalo, H.
    Powiązania:
    https://bibliotekanauki.pl/articles/69674.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Fizjologiczne
    Tematy:
    diet
    fish
    mesenteric artery
    toxic property
    polyunsaturated fatty acid
    lipoprotein
    high saturated fat
    noradrenaline
    vascular response
    fatty acid
    low density lipoprotein
    in vitro
    Źródło:
    Journal of Physiology and Pharmacology; 2000, 51, 2
    0867-5910
    Pojawia się w:
    Journal of Physiology and Pharmacology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Compound heterozygous LDLR variant in severely affected familial hypercholesterolemia patient
    Autorzy:
    Al-Allaf, Faisal
    Alashwal, Abdullah
    Abduljaleel, Zainularifeen
    Taher, Mohiuddin
    Bouazzaoui, Abdellatif
    Abalkhail, Hala
    Al-Allaf, Ahmad
    Athar, Mohammad
    Powiązania:
    https://bibliotekanauki.pl/articles/1038687.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    familial hypercholesterolemia (FH)
    low-density lipoprotein receptor (LDLR)
    compound heterozygous
    missense variant
    frameshift variant
    sequencing
    Arab
    coronary artery disease (CAD)
    cholesterol
    genetics
    Opis:
    Familial hypercholesterolemia (FH) is most commonly caused by mutations in the LDL receptor (LDLR), which is responsible for hepatic clearance of LDL from the blood circulation. We described a severely affected FH proband and their first-degree blood relatives; the proband was resistant to statin therapy and was managed on an LDL apheresis program. In order to find the causative genetic variant in this family, direct exon sequencing of the LDLR, APOB and PCSK9 genes was performed. We identified a compound heterozygous mutation in the proband with missense p.(W577C) and frameshift p.(G676Afs33) variants at exons 12 and 14 of the LDLR gene respectively. DNA sequencing of LDLR gene from the parents demonstrated that the missense variant was inherited from the mother and frameshift variant was inherited from the father. The frameshift variant resulted in a stop signal 33 codons downstream of the deletion, which most likely led to a truncated protein that lacks important functional domains, including the trans-membrane domain and the cytoplasmic tail domain. The missense variant is also predicted to be likely pathogenic and affect EGF-precursor homology domain of the LDLR protein. The segregation pattern of the variants was consistent with the lipid profile, suggesting a more severe FH phenotype when the variants are in the compound heterozygous state. The finding of a compound heterozygous mutation causing severe FH phenotype is important for the genotype-phenotype correlation and also enlarges the spectrum of FH-causative LDLR variants in the Arab population, including the Saudi population.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 75-79
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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