Kinetic analysis of LDL apoB transport and metabolism in non-steady states

In this paper a novel kinetic analysis is used for evaluation of the low density lipoprotein (LDL) apoB fractional catabolic rate (FCR) after LDL apheresis which creates a nonsteady state. The formulae for calculation of FCR, and LDL rate of appearance (Ra) as functions of time have been derived. Calculations for one normal and one familial hypercholesterolemic (FH) subjects showed that FCR as well as Ra exhibited variations which can be attributed to the circadian rhythm in LDL metabolism. LDL apheresis had a little impact on both Ra and FCR in normal as well as in FH subjects. However, Ra in FH subject was found to be much higher than - that in the normal subject.