Skocz do pozycji: 1.

Tytuł:

Antivirals - current trends in fighting influenza

Autorzy:

Król, Ewelina
Rychłowska, Małgorzata
Szewczyk, Bogusław

Powiązania:

https://bibliotekanauki.pl/articles/1039254.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

influenza virus
antivirals
novel anti-influenza drugs
antiviral therapy
inhibitors

Opis:

Influenza virus infection is a major source of morbidity and mortality worldwide. Due to the variable effectiveness of existing vaccines, especially in the early stages of an epidemic, antiviral drugs represent the first line of defense against the virus. Currently, there are two major classes of anti-influenza drugs approved by the FDA for clinical use: M2 protein inhibitors (amantadine and rimantadine) and neuraminidase inhibitors (zanamivir and oseltamivir). However, increasing resistance to these available influenza antivirals among circulating influenza viruses highlights the need to develop alternative approaches for the prevention and/or treatment of influenza. This review presents an overview of currently available drugs for influenza treatment as well as summarizes some new antiviral strategies that are now being tested covering agents targeting both the viral proteins and the host-virus interaction. We discuss their mechanisms of action, resistance and the therapeutic potential as new antiviral drug for use in future influenza pandemics. Additionally, combination therapy based on these drugs is also described.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 495-504
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Tytuł:

Factors affecting decision concerning influenza vaccination among students of medical faculties

Autorzy:

Woźniak-Kosek, Agnieszka
Kempińska-Mirosławska, Bogumiła
Mendrycka, Mariola
Saracen, Agnieszka
Hoser, Grażyna

Powiązania:

https://bibliotekanauki.pl/articles/1039225.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

influenza
vaccination against influenza- knowledge
infections
students

Opis:

Influenza is one of the most common cyclic respiratory diseases in humans. Methods of prevention are multidirectional, but the most effective and most efficacious way to prevent influenza and its complications is through preventive vaccination. This work aims to determine different factors affecting the decision concerning influenza vaccine. The percentage of people vaccinated against the flu was evaluated, as well as their knowledge of post-influenza complications, etc. among full-time students and bridging studies of nursing and physiotherapy (full-time and part-time) at the University of Technology and Life Sciences in Radom, and students of medicine and pharmacy at the Medical University of Łódź. The research tool was the authors' questionnaire with 18 questions. The surveys conducted, consisting of multiple choice questions, were anonymous. In total, the survey involved 470 students. Overall, the number of people who were vaccinated against influenza in the 2012/13 epidemic season numbered 15 respondents, representing 5.84% of the total group of respondents. For the group of nursing students it was 6%, for physiotherapy students 5%, for students of medicine and pharmacy 14%. The percentage of respondents who said they would get vaccinated if the vaccinaton was free of charge was also low. Increasing the percentage of people vaccinated against influenza (immunization coverage) is a very important measure in preventing influenza epidemics. Therefore, it is necessary to identify the reasons why people are reluctant to be vaccinated against influenza, particularly among students who will work in the future in the health care services sector.

Źródło:

Acta Biochimica Polonica; 2014, 61, 4; 829-832
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Tytuł:

Upper respiratory tract infections and influenza-like illnesses among healthcare workers: are serological tests useful in monitoring influenza and influenza-like illness?

Autorzy:

Toczek-Kubicka, Katarzyna
Szenborn, Filip
Kuchar, Ernest P.
Szenborn, Leszek

Powiązania:

https://bibliotekanauki.pl/articles/2153866.pdf

Data publikacji:

2022-12-29

Wydawca:

Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi

Tematy:

IgM antibodies
vaccination
humoral response
influenza
healthcare workers
influenza-like illness

Opis:

Background Healthcare workers (HCWs) are at high risk for exposure to upper respiratory tract infections (URTIs) and influenza-like illnesses (ILIs). The present study aimed to surveil URTIs and ILIs and their impact among the Department of Pediatric Infectious Diseases in Wroclaw employees and evaluate their humoral response to influenza. Material and Methods Thirty-six HCWs participated in the first season and 32 HCWs in the second season during years of the study. The authors carried out a URTI/ILI surveillance, and all HCWs were asked to complete a weekly report during 2 influenza seasons: 2016/2017 (S1) and 2017/2018 (S2). In S1 both IgG and IgM antibodies against influenza A and B were assessed. The HCWs with symptoms of ILI were encouraged to undergo PCR tests for influenza. Results No significant differences in reporting URTI were found among vaccinated and non-vaccinated HCWs and HCWs and the control group. Depending on the year 5.5–17.2% of HCWs were treated with antibiotics because of URTI. In the study 58.7% of participants in S1 and 66.7% in S2 decide to work despite the URTI symptoms. There was no statistical relationship between the concentration of anti-influenza IgG and the number of URTIs and ILIs reported. Only vaccinated were willing to undergo voluntary influenza testing. Conclusions The URTI and ILI occur commonly in HCWs, and HCWs contract URTIs as often as the control group. Despite their medical education, HCWs work with the symptoms of infection and overuse antibiotics to treat the URTI. Serology testing is not able to follow the infection’s dynamics or identify the people immune to the influenza-like illness. The diagnostic value of IgM antibodies in acute influenza infection is negligible. Vaccinated HCWs are more focused on their health and are more willing to undergo influenza tests.

Źródło:

Medycyna Pracy; 2022, 73, 6; 441-447
0465-5893
2353-1339

Pojawia się w:

Medycyna Pracy

Dostawca treści:

Biblioteka Nauki

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Tytuł:

Szczepienia seniorów – profilaktyka chorób zakaźnych na przykładzie szczepienia przeciw grypie
Seniors vaccinations- prevention of contagious diseases on the ex ample of influenza vaccination

Autorzy:

Zawidzka, Magdalena
Nazar, Elżbieta
Kamińska, Marta
Przybylska, Joanna

Powiązania:

https://bibliotekanauki.pl/articles/1029473.pdf

Data publikacji:

2018

Wydawca:

Państwowa Uczelnia Zawodowa we Włocławku

Tematy:

influenza
old age
vaccinations

Opis:

Introduction. Influenza has been known as the most common contagious disease attacking the respiratory system of patients at any age. In addition to influenza vaccination, older people are also advised to vaccinate against pneumonia, hepatitis (Hepatitis B), pertussis, diphtheria and tetanus. The aim of this work is to present the importance of influenza vaccination and senior participation in the "Program for the prevention of contagious diseases with respect to the use of influenza vaccination for people over 65", on the example of Włocławek, Lublin and Wrocław. Overview. Contagious diseases in older people are often characterized by a severe course and an increased risk of complications. Despite the wide-scale infection prevention among the older people, protective vaccinations are the most effective way to prevent influenza, as well as its complications. The number of vaccinated patients over 65 is low. The use of protective vaccinations has a beneficial effect not only on the health of patients, but also on the reduction of treatment costs associated with the occurrence of possible post-influenza complications and long-term hospitalization. Systematic influenza vaccinations are liekely to protect patients from infection and complications, but also stimulate the body's immune system to function properly. Conclusions. Despite the recommendations of health professionals , the popularity of vaccinations among people over 65 is very low. The most common reasons associated with resignation from vaccinations among seniors include: fear of complications associated with vaccination and lack of faith in its effectiveness. For this reason, it is extremely important to effectively promote influenza vaccinations among the elderly.
Wstęp. Grypa to choroba zakaźna układu oddechowego pojawiająca się najczęściej, niezależnie od wieku. Osobom starszym oprócz szczepienia przeciw grypie zaleca się szczepienia przeciw zapaleniu płuc, wirusowemu zapaleniu wątroby (WZW) typu B, krztuścowi, błonicy oraz tężcowi. Celem niniejszej pracy jest przedstawienie istoty szczepienia przeciwko grypie oraz udziału seniorów w „Programie profilaktyki chorób zakaźnych w zakresie szczepień ochronnych przeciw grypie dla osób powyżej 65 roku życia”, na przykładzie miast Włocławek, Lublin oraz Wrocław. Przegląd. Choroby zakaźne występujące u osób w podeszłym wieku często charakteryzują się ciężkim przebiegiem i zwiększonym ryzykiem powikłań. Pomimo szeroko ukierunkowanej prewencji infekcji wśród osób starszych, najbardziej efektywnym oraz najskuteczniejszym sposobem zapobiegania grypie, a także jej powikłaniom, są szczepienia ochronne. Stopień wyszczepienia pacjentów powyżej 65 roku życia jest niski. Stosowanie szczepień ochronnych ma korzystny wpływ nie tylko na zdrowie pacjentów, ale także na obniżenie kosztów leczenia związanych z wystąpieniem ewentualnych powikłań pogrypowych oraz długotrwałej hospitalizacji. Systematyczne powtarzanie szczepień przeciwko grypie pozwala nie tylko chronić przed infekcją oraz powikłaniami, ale także pobudza układ obronny organizmu do skutecznego działania. Wnioski. Pomimo zaleceń specjalistów, popularność szczepień wśród osób po 65 roku życia jest bardzo niska. Do najczęstszych przyczyn związanych z rezygnacją ze szczepień u seniorów należą: lęk przed powikłaniami związanymi ze szczepieniem oraz brak wiary w jego skuteczność. Z tego powodu niezwykle ważne jest efektywne promowanie szczepień przeciw grypie wśród osób w podeszłym wieku.

Źródło:

Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2018, 3, 3; 81-90
2451-1846

Pojawia się w:

Innowacje w Pielęgniarstwie i Naukach o Zdrowiu

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:

Influenza viruses resistant to neuraminidase inhibitors

Autorzy:

Nitsch-Osuch, Aneta
Brydak, Lidia

Powiązania:

https://bibliotekanauki.pl/articles/1039255.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

influenza
resistance
neuraminidase inhibitors

Opis:

Neuraminidase inhibitors (NAIs) are antiviral drugs for treatment and prophylaxis of influenza. By blocking the activity of the enzyme neuraminidase, NAIs prevent new viral particles from being released. The increasing use of NAIs brings into focus the risk of drug resistance arising to the class. There are three levels of antiviral resistance according to the way that resistance can be detected or inferred: genotypic, phenotypic and clinical resistance. For many years seasonal influenza viruses resistance to NAIs was low (0.33%). Recently, there has been described an increasing number of resistant seasonal influenza strains to oseltamivir (2% in adults, 5-18% in children). In 2007 there were published data describing 14% resistant to oseltamivir strains of influenza A/H1N1/ in Europe. Approximately 0.5-1.0% of influenza A/H1N1/pdm09 isolates are currently resistant to oseltamivir. The established markers of the resistance to oseltamivir were found in 2.4% of human and 0.8% of avian isolates of influenza A/H5N1/. It has been not observed a cross resistance among oseltamivir and zanamivir. NAIs resistance in influenza viruses is relative and despite its presence patients with resistant viruses may still benefit from receiving these antivirals. The response to treatment with antivirals remains the most important proof of antiviral effectiveness. The rational use of NAIs is essential to preserve the best choice for treatment and prophylaxis of seasonal, avian and pandemic influenza.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 505-508
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:

Influenza virus hemagglutinin as a vaccine antigen produced in bacteria

Autorzy:

Sączyńska, Violetta

Powiązania:

https://bibliotekanauki.pl/articles/1039263.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

recombinant influenza hemagglutinin
recombinant influenza vaccine
subunit influenza vaccine
bacterial hemagglutinin
prokaryotic protein production

Opis:

Recombinant subunit vaccines based on hemagglutinin proteins produced in bacteria (bacterial HAs) are promising candidates for enhancing the supply of vaccines against influenza, especially for a pandemic. Over 20 years after the failure to obtain the antigen with native HA characteristics in the early 1980’s, there are increasing data on successful production of HA proteins in bacteria. The vast majority of bacterial HAs have been based on the HA1 subunit of HA expressed separately or as a component of conjugate vaccines, but those based on the ectodomain and the HA2 subunit have also been reported. The most of HAs have been efficiently expressed as insoluble aggregates called inclusion bodies. Refolded and purified proteins were extensively studied for structure, the ability to bind to sialic acid-containing receptors, antigenicity, immunogenicity and efficacy. The results from these studies contradict the view that glycosylation determines the correct structure of the hemagglutinin, as they proved that bacterial HAs can be valuable vaccine antigens when appropriate folding and purification methods are applied to rationally designed proteins. The best evidence for success in bacterial production of protective HA is that vaccines based on proprietary Toll-like Receptor (VaxInnate) and bacteriophage Qβ-VLPs (Cytos Biotechnology) technologies have been advanced to clinical studies.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 561-572
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:

Pandemic Influenza Threat

Autorzy:

Kaudhry, Harish
Fangriya, Ruchita

Powiązania:

https://bibliotekanauki.pl/articles/1194041.pdf

Data publikacji:

2015

Wydawca:

Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN

Tematy:

H5N1
human influenza
pandemic influenza
threat

Opis:

The threat of a human influenza pandemic has greatly increased over the past several years with the emergence of highly virulent avian influenza viruses, notably H5N1 viruses, which have infected humans in several Asian and European countries. Previous influenza pandemics have arrived with little or no warning, but the current widespread circulation of H5N1 viruses among avian populations and their potential for increased transmission to humans and other mammalian species may afford us an unprecedented opportunity to prepare for the next pandemic threat. The US Department of Health and Human Services is coordinating a national strategy to respond to an influenza pandemic that involves multiple agencies, including the Centers for Disease Control and Prevention, the Food and Drug Administration, and the National Institutes of Health (NIH). Within NIH, the National Institute of Allergy and Infectious Diseases (NIAID) conducts basic and clinical research to develop new vaccine technologies and antiviral drugs against influenza viruses. We describe recent research progress in preparing for pandemic influenza.

Źródło:

World Scientific News; 2015, 11; 80-96
2392-2192

Pojawia się w:

World Scientific News

Dostawca treści:

Biblioteka Nauki

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Tytuł:

In vivo reassortment of influenza viruses

Autorzy:

Urbaniak, Kinga
Markowska-Daniel, Iwona

Powiązania:

https://bibliotekanauki.pl/articles/1039242.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

influenza A viruses

Opis:

The genetic material of influenza A virus consists of eight negative-sense RNA segments. Under suitable conditions, the segmented structure of the viral genome allows an exchange of the individual gene segments between different strains, causing formation of new reassorted viruses. For reassortment to occur, co-infection with two or more influenza virus strains is necessary. The reassortment is an important evolutionary mechanism which can result in antigenic shifts that modify host range, pathology, and transmission of the influenza A viruses. In this process, the influenza virus strain with epidemic and/or pandemic potential can be created. Cases of this kind were in 1957 (Asian flu), 1968 (Hong Kong flu) and recently in 2009 (Mexico). Viruses containing genes of avian, swine, and/or human origin are widespread around the world, for example the triple reassortant H1N1 virus causing the 2009 influenza pandemic in 2009 that has become a seasonal virus. The aim of the study is to present the mechanism of reassortment and the results of experimental co-infection with different influenza viruses.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 427-431
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:

Vaccination against influenza in pregnant women

Autorzy:

Brydak, Lidia
Nitsch-Osuch, Aneta

Powiązania:

https://bibliotekanauki.pl/articles/1039266.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

influenza
vaccination
pregnancy

Opis:

Pregnancy places otherwise healthy women at an increased risk of complications arising from an influenza infection. It is suggested that physiological changes such as immunological changes, increased cardiac output and oxygen consumption, as well as lung tidal volume might increase the susceptibility to influenza complications if infection occurs during pregnancy. Immunization of pregnant women against influenza is currently recommended in many countries and has been proven to be safe and effective in reducing rates and severity of the disease in vaccinated mothers and their children. Influenza vaccination is also cost-effective. Nevertheless, influenza vaccine coverage remains low in pregnant women. This might stem from the lack of healthcare workers' education, a feeling among the general public that influenza is not a serious disease and a failure of prenatal care providers to offer the vaccine. In order to protect pregnant women and infants from influenza related morbidity and mortality an educational programme targeting healthcare workers in charge of pregnant women should be implemented.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 589-591
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:

Influenza vaccine efficacy in patients aged 60–75 years in the 2016/2017 season

Autorzy:

Sławin, Agata
Brydak, Lidia
Doniec, Zbigniew
Mastalerz-Migas, Agnieszka

Powiązania:

https://bibliotekanauki.pl/articles/552677.pdf

Data publikacji:

2018

Wydawca:

Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych

Tematy:

influenza
human
vaccination
aged
immunization

Źródło:

Family Medicine & Primary Care Review; 2018, 3; 263-266
1734-3402

Pojawia się w:

Family Medicine & Primary Care Review

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:

Zakażenia wirusem grypy typu A u gołębi
Influenza A virus infections of pigeons

Autorzy:

Abolnik, Celia

Powiązania:

https://bibliotekanauki.pl/articles/22016002.pdf

Data publikacji:

2020

Wydawca:

Krajowa Izba Lekarsko-Weterynaryjna

Tematy:

ptaki
wirus influenzy A
epidemiologia
gołębie
choroby zwierząt
influenza ptaków
avian influenza
epidemiology
pigeons

Opis:

Influenza A viruses of all subtypes, in their low pathogenic state, form part of the natural microbiota of water bird species. Four intercontinental transmission waves of Goose/Guangdong H5 lineage viruses swept the globe since 2005, each characterized by epidemics in poultry and contact transmission to humans. A significant shift in ecology of avian influenza had occurred. The risks that columbids pose in the ecology and epidemiology of AI have been thoroughly investigated over the course of several decades. Cumulatively, the studies on free-living pigeons, market pigeons and those experimentally infected with LPAI and HPAI demonstrated, that pigeons were of no epidemiological significance in the transmission and spread of HPAI to humans.

Źródło:

Życie Weterynaryjne; 2020, 95, 06; 362-364
0137-6810

Pojawia się w:

Życie Weterynaryjne

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:

Seasonal influenza vaccination of healthcare workers: a narrative review

Autorzy:

Jędrzejek, Michał J.
Mastalerz-Migas, Agnieszka

Powiązania:

https://bibliotekanauki.pl/articles/2084883.pdf

Data publikacji:

2022-04-11

Wydawca:

Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi

Tematy:

infection control
influenza
healthcare facilities
healthcare workers
healthcare personnel
influenza vaccination

Opis:

Influenza is an acute respiratory disease caused by the influenza virus which often occurs in outbreaks and epidemics worldwide. The World Health Organization recommends annual vaccination of healthcare workers (HCWs) against influenza, because most of them are involved in the direct care of patients with a high risk of influenza-related complications. Given the significance of the disease burden, a targeted literature review was conducted to assess issues related to influenza vaccination among HCWs. The primary aim of this review was to assess the incidence of influenza among medical personnel and healthcare-associated influenza, and to outline the benefits of influenza vaccination for patients and HCWs themselves. Vaccination of HCWs seems to be an important strategy for reducing the transmission of influenza from healthcare personnel to their patients and, therefore, for reducing patient morbidity and mortality, increasing patient safety, and reducing work absenteeism among HCWs. The benefits of influenza vaccination for their patients and for HCWs themselves are addressed in literature, but the evidence is mixed and often of low-quality.

Źródło:

International Journal of Occupational Medicine and Environmental Health; 2022, 35, 2; 127-139
1232-1087
1896-494X

Pojawia się w:

International Journal of Occupational Medicine and Environmental Health

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:

Hemagglutinin stalk domain from H5N1 strain as a potentially universal antigen

Autorzy:

Uranowska, Karolina
Tyborowska, Jolanta
Jurek, Anna
Szewczyk, Bogusław
Gromadzka, Beata

Powiązania:

https://bibliotekanauki.pl/articles/1039261.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

H5N1
universal influenza antigen
hemagglutinin stalk domain
universal influenza antibodies
FI6

Opis:

Influenza A virus infections are the major public health concern and cause significant morbidity and mortality each year worldwide. Vaccination is the main strategy of influenza epidemic prevention. However, seasonal vaccines induce strain-specific immunity and must be reformulated annually based on prediction of the strains that will circulate in the next season. Thus, it is essential to develop vaccines that would induce broad and persistent immunity to influenza viruses. Hemagglutinin is the major surface antigen of the influenza virus. Recent studies revealed the importance of HA stalk-specific antibodies in neutralization of different influenza virus strains. Therefore, it is important to design an immunogen that would focus the immune response on the HA stalk domain in order to elicit neutralizing antibodies. In the present study, we report characterization of a conserved truncated protein, potentially a universal influenza virus antigen from the H5N1 Highly Pathogenic Avian Influenza A virus strain. Our results indicate that exposure of the HA stalk domain containing conserved epitopes results in cross reactivity with different antibodies (against group 1 and 2 HAs). Additionally, we conclude that HA stalk domain contains not only conformational epitopes recognized by universal FI6 antibody, but also linear epitopes recognized by other antibodies.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 541-550
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:

ReCOMmendations for the treatment of INFLUENZA in children for Primary care physiciAnS – COMPAS INFLUENZA

Autorzy:

Doniec, Zbigniew
Mastalerz-Migas, Agnieszka
Jackowska, Teresa
Kuchar, Ernest
Sybilski, Adam

Powiązania:

https://bibliotekanauki.pl/articles/552248.pdf

Data publikacji:

2019

Wydawca:

Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych

Tematy:

influenza
children
treatment
vaccinations.

Opis:

Influenza is an acute infectious disease of the airways that occurs in every age group. The course of the disease may have a different severity and clinical picture, from asymptomatic to severe with symptoms of respiratory failure. The possibilities of pandemic infections and serious complications throughout the course of influenza distinguish it from other viral respiratory diseases, prompting us to treat it in a special way. Diagnosis of the disease is usually clinical in nature, and additional studies may be helpful in clinically relevant cases. The drug recommended for treatment and chemoprophylaxis is oseltamivir. Clinical benefits are greatest if treatment starts as early as possible, within 48 hours of the first symptoms of influenza. Clinical studies indicate that early treatment with oseltamivir may shorten the duration of the disease and reduce the risk of its complications. Annual influenza vaccination is the most effective method of preventing this disease, and the only contraindication to vaccination is the occurrence of an anaphylactic or other severe allergic reaction after a previous vaccination

Źródło:

Family Medicine & Primary Care Review; 2019, 2; 189-198
1734-3402

Pojawia się w:

Family Medicine & Primary Care Review

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:

Testing of human specimens for the presence of highly pathogenic zoonotic avian influenza virus A [H5N1] in Poland in 2006-2008 - justified or unnecessary steps?

Autorzy:

Romanowska, M
Nowak, I.
Brydak, L.B.
Wojtyla, A.

Powiązania:

https://bibliotekanauki.pl/articles/50626.pdf

Data publikacji:

2009

Wydawca:

Instytut Medycyny Wsi

Tematy:

avian influenza virus type A
zoonosis
influenza
H5N1 subtype
avian influenza
disease outbreak
diagnostic test
Polska

Źródło:

Annals of Agricultural and Environmental Medicine; 2009, 16, 2; 239-247
1232-1966

Pojawia się w:

Annals of Agricultural and Environmental Medicine

Dostawca treści:

Biblioteka Nauki

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Tytuł:

A clinical utility of a strip test for influenza A/B and comparison with detection by RT PCR

Autorzy:

Miarka, Maciej
Horban, Andrzej
Maliszewska, Henryka
Biliński, Przemysław
Prus-Kowalczuk, Wanda

Powiązania:

https://bibliotekanauki.pl/articles/1039251.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

A/H1N1/v influenza virus
strip test
influenza RT PCR

Opis:

Introduction and objective: In June 2009 the World Health Organization announced influenza pandemic caused by A/H1N1/v virus. It became crucial to recognize new cases of A/H1N1/v infection. An effective screening diagnostic procedure was needed for patients suffering from influenza-like symptoms for making an initial diagnosis and analyzing epidemiological pattern of infection. We used a strip test for influenza A/B as a screening diagnostic procedure for patients suffering from influenza-like symptoms for making an initial diagnosis. For comparison, RT PCR for detecting A/H1N1/v was performed. The aim of this study was to assess the efficacy and sensitivity of the strip test and its value for making initial diagnosis of influenza A/H1N1/v. Material and methods: Strip testing for the influenza A/B infection was performed on 1123 patients with influenza-like symptoms in the Admission Unit of the Regional Infectious Diseases Hospital in Warsaw. Strip test results were analyzed according to the age of patients and season of the year. For 97 patients strip test results for detecting A/H1N1 infection were compared with those obtained by RT PCR. Results: There were no statistically significant differences found between the methods and strip testing demonstrated sensitivity of 61% and specificity of 71%. Conclusions: No statistically significant differences were found between the two methods, however, strip test had low sensitivity and specificity.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 485-487
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 17.

Tytuł:

Influenza A viruses of avian origin circulating in pigs and other mammals

Autorzy:

Urbaniak, Kinga
Kowalczyk, Andrzej
Markowska-Daniel, Iwona

Powiązania:

https://bibliotekanauki.pl/articles/1039243.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

influenza A viruses
hemagglutinin
neuraminidase

Opis:

Influenza A viruses (IAVs) are zoonotic agents, capable of crossing the species barriers. Nowadays, they still constitute a great challenge worldwide. The natural reservoir of all influenza A viruses are wild aquatic birds, despite the fact they have been isolated from a number of avian and mammalian species, including humans. Even when influenza A viruses are able to get into another than waterfowl population, they are often unable to efficiently adapt and transmit between individuals. Only in rare cases, these viruses are capable of establishing a new lineage. To succeed a complete adaptation and further transmission between species, influenza A virus must overcome a species barrier, including adaptation to the receptors of a new host, which would allow the virus-cell binding, virus replication and, then, animal-to-animal transmission. For many years, pigs were thought to be intermediate host for adaptation of avian influenza viruses to humans, because of their susceptibility to infection with both, avian and human influenza viruses, which supported hypothesis of pigs as a 'mixing vessel'. In this review, the molecular factors necessary for interspecies transmission are described, with special emphasis on adaptation of avian influenza viruses to the pig population. In addition, this review gives the information about swine influenza viruses circulating around the world with special emphasis on Polish strains.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 433-439
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 18.

Tytuł:

Diversity of influenza-like illness etiology in Polish Armed Forces in influenza epidemic season

Autorzy:

Kocik, Janusz
Niemcewicz, Marcin
Winnicka, Izabela
Michalski, Aleksander
Bielawska-Drózd, Agata
Kołodziej, Marcin
Joniec, Justyna
Cieślik, Piotr
Graniak, Grzegorz
Mirski, Tomasz
Gaweł, Jerzy
Bielecka-Oder, Anna
Kubiak, Leszek
Russell, Kevin

Powiązania:

https://bibliotekanauki.pl/articles/1039252.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Influenza
ILI
surveillance
Polish Army

Opis:

The aim of this study was to conduct an epidemiological and laboratory surveillance of Influenza-Like Illnesses (ILI) in Polish Armed Forces, civilian military personnel and their families in 2011/2012 epidemic season, under the United States Department of Defense-Global Emerging Infections Surveillance and Response System (DoD-GEIS). ILI incidence data were analyzed in relation to age, gender, patient category as well as pathogen patterns. Multiple viral, bacterial and viral-bacterial co-infections were identified. Nose and throat swabs of active duty soldiers in the homeland country and in the NATO peacekeeping forces KFOR (Kosovo Force), as well as members of their families were tested for the presence of viral and bacterial pathogens. From October 2011 to May 2012, 416 specimens from ILI symptoms patients were collected and analyzed for the presence of viral and bacterial pathogens. Among viruses, coronavirus was the most commonly detected. In the case of bacterial infections, the most common pathogen was Staphylococcus aureus.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 489-494
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 19.

Tytuł:

Influenza vaccination among healthcare workers – realization, promotion

Autorzy:

Tomaszewski, Mateusz
Łuniewski, Michał
Kulczyński, Marcin
Olender, Alina

Powiązania:

https://bibliotekanauki.pl/articles/1179527.pdf

Data publikacji:

2017

Wydawca:

Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN

Tematy:

Vaccines
healthcare workers
infectious disease prevention
influenza

Opis:

Influenza vaccination is the most important component of prevention of occurring and spreading of this disease. 80% vaccination coverage of healthcare personnel provides a substantial reduction of transmission; each and every next vaccinated person results in a decrease of morbidity, especially amongst elder or immunocompromised patients. In the analyzed studies most common reasons of insufficient vaccination coverage among healthcare workers were fear of side effects, lack of knowledge, conviction of vaccine inefficiency, lack of feeling of social responsibility, and inadequate accessibility of vaccine. Healthcare workers who were vaccinated regularly did it mostly in order to provide safety to themselves, their relatives and patients; they did it also due to the knowledge of vaccination efficiency. The most effective actions to improve vaccination coverage were: vaccination requirement by the employer, active encouragement, effective promotion, better vaccine accessibility and promotion of vaccination as prosocial behavior. Offering surgical masks as an alternative did not improve vaccination rate in most analyzed studies. In conclusion, most important reasons of declining influenza vaccination by healthcare workers are lack of knowledge and low accessibility of vaccination, so evidently education, promotion and facilitating the vaccination in workplace are the most effective ways causing the growth of vaccination rate.

Źródło:

World Scientific News; 2017, 76; 50-59
2392-2192

Pojawia się w:

World Scientific News

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 20.

Tytuł:

The impact of selected educational and information interventions on the coverage rate and attitudes to influenza vaccination in nursing staff

Autorzy:

Gołębiak, Izabela
Okręglicka, Katarzyna
Kanecki, Krzysztof
Nitsch-Osuch, Aneta

Powiązania:

https://bibliotekanauki.pl/articles/2087444.pdf

Data publikacji:

2020-12-03

Wydawca:

Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi

Tematy:

education
vaccination
influenza
attitude
nursing staff
intervention

Opis:

BackgroundInfluenza vaccinations are recommended for medical staff as an effective and safe form of preventing influenza and its complications. The aim of the study was to assess the impact of selected educational and information interventions on the influenza vaccination coverage (IVC) in nursing personnel and their attitude towards this procedure.Material and MethodsThe study participants (N = 320) were randomly divided into 4 groups. Group 1 participated in stationary training, whereas group 2 participated in distance learning. Additionally, 2 subgroups were established in each of the groups above: 1 subgroup received a reminder about the vaccination in the form of a short text message, and the other group did not receive any such reminder. The IVC rate in each group was determined; the attitude towards influenza vaccination was measured using the health belief model.ResultsThe highest IVC was obtained after stationary training followed by a reminder in the form of a short test message (36%). The reminder significantly affected IVC in the group attending stationary training (p < 0.05, OR = 2.5, 95% CI: 1.16–5.58); however, it had no impact on the IVC in the group participating in distance learning (p > 0.05, OR = 1.2, 95% CI: 0.51–2.83). Both stationary training and distance learning positively influenced the attitude towards influenza vaccinations. A major change in attitudes towards influenza vaccinations was observed only in the case of stationary training followed by a reminder in the form of a short text message (positive changes in perceived susceptibility and severity took place, perceived vaccination benefits increased, and perceived barriers were reduced).ConclusionsStationary training followed by a reminder in the form of a short text message is more effective in increasing the IVC rate compared to distance learning. It also promotes positive changes in attitudes to this prophylactic procedure, which is why it should be recommended for wider implementation.

Źródło:

Medycyna Pracy; 2020, 71, 6; 665-685
0465-5893
2353-1339

Pojawia się w:

Medycyna Pracy

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 21.

Tytuł:

Evaluation of the knowledge, attitudes and behavior of healthcare workers concerning influenza vaccination in a training and research hospital in Türkiye

Autorzy:

Apaydin, Mehmet
Dogan, Serap
Aypak, Cenk

Powiązania:

https://bibliotekanauki.pl/articles/40570856.pdf

Data publikacji:

2024-06-30

Wydawca:

Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego

Tematy:

attitude
behavior
healthcare workers
influenza vaccine
knowledge

Opis:

Introduction and aim. Although increasing vaccination rates among healthcare workers (HCWs) is crucial for protecting their own health and preventing the spread of infections to patients, vaccination rates remain low. The purpose of this study is to evaluate the knowledge, attitudes, and behavior of healthcare workers concerning seasonal influenza vaccination in a training and research hospital in Türkiye. Material and methods. This cross-sectional descriptive study was conducted among 364 healthcare workers working in a training and research hospital in Ankara, Türkiye. A face-to-face questionnaire was completed by selected participants that included questions about their sociodemographic characteristics, receiving seasonal influenza vaccination, reasons for not receiving vaccination, attitudes and behavior towards seasonal influenza vaccination recommendations for their surroundings, knowledge of who should get the vaccine, and their immunization history. Results. Among the participants, 58.5% stated that they had never received an influenza vaccination, 35.7% mentioned not receiving the regular influenza vaccination, and only 5.8% reported receiving the influenza vaccination regularly every year. Reasons for not getting vaccinated included not trusting the influenza vaccine’s protection (60.1%), not believing they are in the risk group (38.9%), and not finding a suitable time to get vaccinated (36.1%). A total of 57.1% of the healthcare workers recommended the influenza vaccine for their surroundings. Conclusion. Influenza vaccination rates among healthcare workers are quite low. To maximize influenza vaccine uptake, awareness programs are needed to correct the misconceptions health care workers have about the vaccine, and diverse strategies should be implemented to encourage them to get vaccinated, thereby promoting influenza vaccination.

Źródło:

European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 313-319
2544-2406
2544-1361

Pojawia się w:

European Journal of Clinical and Experimental Medicine

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 22.

Tytuł:

Role of the host genetic variability in the influenza A virus susceptibility

Autorzy:

Arcanjo, Ana
Mazzocco, Giovanni
de Oliveira, Silviene
Plewczynski, Dariusz
Radomski, Jan

Powiązania:

https://bibliotekanauki.pl/articles/1039238.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Influenza A virus
host-pathogen interactions

Opis:

The aftermath of influenza infection is determined by a complex set of host-pathogen interactions, where genomic variability on both viral and host sides influences the final outcome. Although there exists large body of literature describing influenza virus variability, only a very small fraction covers the issue of host variance. The goal of this review is to explore the variability of host genes responsible for host-pathogen interactions, paying particular attention to genes responsible for the presence of sialylated glycans in the host endothelial membrane, mucus, genes used by viral immune escape mechanisms, and genes particularly expressed after vaccination, since they are more likely to have a direct influence on the infection outcome.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 403-419
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 23.

Tytuł:

A universal flu vaccine

Autorzy:

Kesik-Brodacka, Malgorzata
Plucienniczak, Grazyna

Powiązania:

https://bibliotekanauki.pl/articles/1039259.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

universal vaccine
flu vaccine
influenza virus

Opis:

Influenza is a global health concern. The single most effective way of protecting people against influenza infection and disease is vaccination. However, currently available vaccines against influenza induce only strain-specific immunity, and do not elicit long-lasting serum antibody titers. Therefore, they are ineffective in the case of possible pandemics. There is an urgent need for a new generation vaccine which would induce broad and long-lasting immune protection against antigenically distinct flu viruses. The paper presents recent achievements and the challenges in the field of universal vaccine construction.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 523-530
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 24.

Tytuł:

Aktualna sytuacja epidemiologiczna grypy w województwie śląskim
Current epidemiological situation of influenza in Silesian voivodeship

Autorzy:

Kowalska, Małgorzata

Powiązania:

https://bibliotekanauki.pl/articles/1426961.pdf

Data publikacji:

2021-05-05

Wydawca:

Śląski Uniwersytet Medyczny w Katowicach

Tematy:

grypa
epidemiologia
rejestr
influenza
epidemiology
registry

Opis:

Grypa jest chorobą zakaźną układu oddechowego podlegającą stałemu monitorowaniu w zakresie liczby nowych zachorowań oraz zgonów. W drugiej połowie marca 2020 r. zaobserwowano spadek liczby zachorowań na grypę w woj. śląskim i postanowiono sprawdzić, czy ma to związek z pojawieniem się nowego zagrożenia, jakim jest pandemia COVID. W modelu badania opisowego dokonano analizy trendu zachorowalności i hospitalizacji z powodu grypy, a jednocześnie przedstawiono dynamikę wzrostu nowych zakażeń wirusem SARS-CoV-2. Dokonano również chronologicznego usystematyzowania ważnych działań administracyjnych ograniczających rozwój epidemii. Nie można wykluczyć, że obserwowany spadek zachorowań i hospitalizacji z powodu grypy w woj. śląskim ma związek z restrykcyjnymi przepisami organizacji pracy i życia społecznego podjętymi dla ograniczenia epidemii COVID. Jednoznaczne wnioskowanie będzie wymagało wnikliwych badań i dłuższego okresu obserwacji.
Influenza is an infectious disease of the respiratory system subject to constant monitoring in terms of the number of new cases and deaths. It was observed that the number of new cases of influenza decreased in the Silesian voivodeship in the second half of March 2020, and it was decided to verify whether it is related to the emergence of a new threat, which is the COVID pandemic. In the descriptive model of the study, the trend of influenza morbidity and hospitalization was analyzed, and at the same time the dynamics of the increase in new SARS-CoV-2 infections was presented. Chronological systematization of important administrative activities limiting development of the epidemic was also carried out. It cannot be ruled out that the observed decrease in the incidence and hospitalization due to influenza in the province of Silesia is related to the restrictive regulations on the organization of work and social life taken to minimize the COVID epidemic. Unambiguous conclusions will require in-depth research and a longer observation period.

Źródło:

Annales Academiae Medicae Silesiensis; 2021, 75; 33-40
1734-025X

Pojawia się w:

Annales Academiae Medicae Silesiensis

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 25.

Tytuł:

Opinions and behavior of family doctors concerning vaccinating against influenza

Autorzy:

Gutknecht, Piotr
Winiarski, Tomasz
Trzeciak, Bartosz
Molisz, Andrzej
Pietrzykowska, Małgorzata
Nowicka-Sauer, Katarzyna
Siebert, Janusz

Powiązania:

https://bibliotekanauki.pl/articles/552798.pdf

Data publikacji:

2016

Wydawca:

Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych

Tematy:

vaccination
influenza
family doctor
questionnaire
health care
employees.

Źródło:

Family Medicine & Primary Care Review; 2016, 3; 241-243
1734-3402

Pojawia się w:

Family Medicine & Primary Care Review

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 26.

Tytuł:

DNA vaccines against influenza

Autorzy:

Stachyra, Anna
Góra-Sochacka, Anna
Sirko, Agnieszka

Powiązania:

https://bibliotekanauki.pl/articles/1039258.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

DNA vaccine
influenza
hemagglutinin
immunization
adjuvant
cross-protection

Opis:

Genetic vaccine technology has been considerably developed within the last two decades. This cost effective and promising strategy can be applied for therapy of cancers and for curing allergy, chronic and infectious diseases, such as a seasonal and pandemic influenza. Despite numerous advantages, several limitations of this technology reduce its performance and can retard its commercial exploitation in humans and its veterinary applications. Inefficient delivery of the DNA vaccine into cells of immunized individuals results in low intracellular supply of suitable expression cassettes encoding an antigen, in its low expression level and, in turn, in reduced immune responses against the antigen. Improvement of DNA delivery into the host cells might significantly increase effectiveness of the DNA vaccine. A vast array of innovative methods and various experimental strategies have been applied in order to enhance the effectiveness of DNA vaccines. They include various strategies improving DNA delivery as well as expression and immunogenic potential of the proteins encoded by the DNA vaccines. Researchers focusing on DNA vaccines against influenza have applied many of these strategies. Recent examples of the most successful modern approaches are discussed in this review.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 515-522
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 27.

Tytuł:

Plant expression systems for production of hemagglutinin as a vaccine against influenza virus

Autorzy:

Redkiewicz, Patrycja
Sirko, Agnieszka
Kamel, Katarzyna
Góra-Sochacka, Anna

Powiązania:

https://bibliotekanauki.pl/articles/1039262.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

recombinant hemagglutinin
avian influenza
plant-produced
VLP
ELISA

Opis:

Many examples of a successful application of plant-based expression systems for production of biologically active recombinant proteins exist in the literature. These systems can function as inexpensive platforms for the large scale production of recombinant pharmaceuticals or subunit vaccines. Hemagglutinin (HA) is a major surface antigen of the influenza virus, thus it is in the centre of interests of various subunit vaccine engineering programs. Large scale production of recombinant HA in traditional expression systems, such as mammalian or insect cells, besides other limitations, is expensive and time-consuming. These difficulties stimulate an ever-increasing interest in plant-based production of this recombinant protein. Over the last few years many successful cases of HA production in plants, using both transient and stable expression systems have been reported. Various forms of recombinant HA, including monomers, trimers, virus like particles (VLPs) or chimeric proteins containing its fusion with other polypeptides were obtained and shown to maintain a proper antigenicity. Immunizations of animals (mice, ferrets, rabbits or chickens) with some of these plant-derived hemagglutinin variants were performed, and their effectiveness in induction of immunological response and protection against lethal challenge with influenza virus demonstrated. Plant-produced recombinant subunit vaccines and plant-made VLPs were successfully tested in clinical trials (Phase I and II) that confirmed their tolerance and immunogenicity.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 551-560
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 28.

Tytuł:

Wybrane zioła w prewencji i wspomaganiu leczenia wirusowych infekcji dróg oddechowych
Selected herbs in the prevention and treatment of viral respiratory infections

Autorzy:

Siudem, Paweł

Powiązania:

https://bibliotekanauki.pl/articles/2138924.pdf

Data publikacji:

2022-08-01

Wydawca:

Wydawnictwo Naukowe Medyk sp. z o.o.

Tematy:

grypa
COVID-19
substancje roślinne
influenza
natural products

Opis:

Każdego roku w sezonie przeziębień i grypy obserwuje się wzrost zachorowań na wirusowe infekcje dróg oddechowych oraz inne choroby wirusowe. Podstawowym sposobem zapobiegania chorobom wirusowym są szczepienia. Nie zawsze jednak możliwe jest przyjęcie szczepienia bądź odporność po pewnym czasie wygasa. Wsparciem zarówno w zapobieganiu, jak i leczeniu mogą być liczne surowce roślinne. W tym artykule przedstawiono przegląd kilku wybranych surowców roślinnych, głównie skupiając się na ich wpływie na grypę i infekcję koronawirusem COVID-19.
Every year, during the cold and flu season, an increase in the incidence of viral respiratory infections and other viral diseases is observed. Vaccination is the primary method of preventing viral diseases. However, it is not always possible to be vaccinated, or the immunity expires after some time. Numerous plant materials can support both prevention and treatment. This article provides an overview of a few selected plant materials, mainly focusing on their impact on influenza and COVID-19 infection.

Źródło:

Lek w Polsce; 2022, 375, 07-08; 13-20
2353-8597

Pojawia się w:

Lek w Polsce

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 29.

Tytuł:

Prendre la grippe comme on prend les eaux : variations caricaturales sur un mal à la mode entre 1830 et 1848
The flu as a “mal à la mode”: caricatural glimpses of an epidemic in the French press between 1830 and 1848

Autorzy:

de Palacio, Marie-France

Powiązania:

https://bibliotekanauki.pl/articles/1038094.pdf

Data publikacji:

2020-12-30

Wydawca:

Katolicki Uniwersytet Lubelski Jana Pawła II. Wydawnictwo Werset

Tematy:

grippe
épidémie
caricature
Physiologies
types
presse
influenza
epidemics
press

Opis:

La période de la Monarchie de Juillet est jalonnée d'épidémies de grippes, dont il est régulièrement rendu compte dans la presse. Étonnamment, tandis que les effets de ces épisodes contagieux sont systématiquement minorés, la grippe elle-même fait l'objet de nombreuses charges textuelles et visuelles et d'analogies avec la vie politique, sociale, économique et culturelle. La Grippe aux mille visages, mégère, diable ou femme du monde, est déjà celle que Cham nommera « la lionne de la saison » en 1858. Épidémie obligeante, elle s'associe au carnaval et aux bals qu ’elle perturbe ou agrémente. L'article s'interroge sur le choix d'un tel motif comme moyen satirique et évoque les modalités de cette charge qui passe simultanément par l'atténuation et l'outrance. C'est du côté de la littérature des Physiologies qu'il convient de chercher l'explication de cette typification de la grippe et celle de son statut de « mal à la mode ».
Under the reign of King Louis-Philippe, 1830-1848, France was severely visited by a number of epidemics, namely, influenza, which were regularly reported in the press. Although the effects of such epidemics were methodically undervalued, the flu was frequently caricatured as offering analogies with the political, social and cultural life of the time. It was often endowed with the characteristics of a rational being, she-devil, woman of distinction or termagant of a wife! In 1858, Cham will even call it “the lioness of the day”. The flu will be found congenial with such social assemblies as carnivals or balls, which it either disrupted or embellished. The present paper deals with the satirical purport of the flu, whether underrated or exaggerated, showing at the same time how it became typified as a “mal à la mode” akin to Physiologies, a widely-discussed topic at that time.

Źródło:

Quêtes littéraires; 2020, 10; 9-41
2084-8099
2657-487X

Pojawia się w:

Quêtes littéraires

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 30.

Tytuł:

Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method

Autorzy:

Radomski, Jan
Słonimski, Piotr
Zagórski-Ostoja, Włodzimierz
Borowicz, Piotr

Powiązania:

https://bibliotekanauki.pl/articles/1039244.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

ISSCOR descriptors
phylogenetic analysis
influenza virus
hemagglutinin
phylogenetic maps

Opis:

Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we consider application of the ISSCOR-PCA method for analyses of large sets of homologous genes to be a worthwhile addition to a toolbox of genomics - allowing for a rapid diagnostics of trends, and ultimately even aiding an early warning of newly emerging epidemiological threats.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 441-451
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 31.

Tytuł:

Electrochemical biosensors for detection of avian influenza virus - current status and future trends

Autorzy:

Grabowska, Iwona
Malecka, Kamila
Jarocka, Urszula
Radecki, Jerzy
Radecka, Hanna

Powiązania:

https://bibliotekanauki.pl/articles/1039249.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

electrochemical biosensors
genosensors
immunosensors
electrochemical detection
avian influenza virus

Opis:

Electrochemical biosensors have emerged as reliable analytical devices suitable for pathogen detection. Low cost, small sample requirement and possibility of miniaturization justifies their increasing development. Thus, we report in this review on the state of the art of avian influenza virus detection with genosensors and immunosensors working by an electrochemical mode. Their working principles focusing on the physical properties of the transducer, the immobilization chemistry, as well as new trends including incorporation of nanoparticles will be presented. Then, we critically review the detection of avian influenza virus in the complex matrices that use electrochemical biosensors and compare them with traditionally applied methods such as ELISA or Western blot.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 471-478
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 32.

Tytuł:

Serological surveillance of avian influenza virus and canine distemper virus in captive Siberian Tigers in Northeastern China

Autorzy:

Wang, K.
Wang, H.
Feng, N.
Zhao, Y.
Gao, Y.
Hu, G.
Xia, X.

Powiązania:

https://bibliotekanauki.pl/articles/2087698.pdf

Data publikacji:

2018

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

influenza A virus
canine distemper virus
serological
Siberian Tiger

Źródło:

Polish Journal of Veterinary Sciences; 2018, 21, 3; 491-495
1505-1773

Pojawia się w:

Polish Journal of Veterinary Sciences

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 33.

Tytuł:

Avian influenza in Poland

Autorzy:

Śmietanka, Krzysztof
Minta, Zenon

Powiązania:

https://bibliotekanauki.pl/articles/1039245.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

avian influenza
H5N1 virus

Opis:

Poland has experienced four episodes of avian influenza (AI) outbreaks over the past two decades. The first epidemic was caused by a low pathogenicity (LPAIV) H7N7 subtype and occurred in fattening and breeder turkeys in 1995. Two waves of H5N1 high pathogenicity avian influenza (HPAI) took place in 2006 and 2007. In spring 2006, 64 cases of the H5N1 virus were detected, mostly in mute swans. In December 2007, ten outbreaks of H5N1 HPAI were detected in commercial poultry (n=9) and wild birds kept in captivity (n=1). The outbreaks in 2006 and 2007 were caused by genetically similar but clearly distinguishable viruses of the 2.2 clade. In 2013, an H9N2 avian influenza virus was detected in 4 fattening turkey holdings. The virus was low pathogenic and a phylogenetic study has shown a close relatedness to the Eurasian lineage of AIV of the wild bird origin. Neither preventive nor prophylactic vaccinations have ever been used in poultry or other birds. Emergency vaccinations using autogenous vaccine were introduced only to control the H7N7 LPAI outbreaks in 1995. The baseline surveillance for AI in live migratory birds and poultry provides a valuable insight into the ecology of AIV at the wild and domestic bird interface. Passive surveillance is in place of early detection of HPAIV infection in dead or moribund birds.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 453-457
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 34.

Tytuł:

Native nucleic acid electrophoresis as an efficient alternative for genotyping method of influenza virus

Autorzy:

Pajak, Beata
Lepek, Krzysztof

Powiązania:

https://bibliotekanauki.pl/articles/1039250.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

gel electrophoresis
SSCP
influenza
minor genetic variants

Opis:

Influenza viruses are the worldwide major causative agents of human and animal acute respiratory infections. Some of the influenza subtypes have caused epidemics and pandemics among humans. The varieties of methods are available for the rapid isolation and identification of influenza viruses in clinical and environmental samples. Since nucleic acids amplification techniques such as RT-PCR have been adapted, fast and sensitive influenza type and subtype determination is possible. However, in some ambiguous cases other, more detailed assay might be desired. The genetic material of influenza virus is highly unstable and constantly mutates. It is known that single nucleotide polymorphisms (SNPs) results in resistance to commercially available anti-viral drugs. The genetic drift of the virus could also result in weakening of immune response to infection. Finally, in a substantial number of patients co-infection with various virus strains or types has been confirmed. Although the detection of co-infection or presence of minor genetic variants within flu-infected patients is not a routine procedure, a rapid and wide spectrum diagnostics of influenza virus infections could reveal an accurate picture of the disease and more importantly, is crucial for choosing the appropriate therapeutics and virus monitoring. Herein we present the evidences that native gel electrophoresis and MSSCP - a method based on multitemperature single strand conformation polymorphism could furnish a useful technique for minor variants, which escape discovery by conventional diagnostic assays.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 479-483
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 35.

Tytuł:

Active surveillance in poultry in Poland for avian influenza subtypes H5 and H7

Autorzy:

Pikuła, Anna
Śmietanka, Krzysztof
Lisowska, Anna
Minta, Zenon

Powiązania:

https://bibliotekanauki.pl/articles/1039246.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

avian influenza virus (AIV)
poultry
surveillance
hemagglutination inhibition test (HI)

Opis:

A serological surveillance programme for avian influenza A virus (AIV) subtype H5 and H7 in poultry was implemented in Poland in 2008-2013 with two main objectives: i) to detect subclinical infections or previous exposures to AIV H5 and H7 subtypes and ii) to demonstrate the AI- free status of Poland. During this period, over 45 000 serum samples from 2833 holdings were examined using the hemagglutination inhibition test (HI). The presence of HI antibodies was detected in 8 breeder geese holdings (7 positive for H5 and 1 positive for H7 AIV) and in 1 breeder duck holding (H5-positive), which represented 0.32% of all investigated holdings. All seropositive flocks were examined by real time RT-PCR with negative results, which substantiated the AI-free status of Poland. Positive results detected in clinically healthy poultry kept in an open range system indicate prior infections with low pathogenic AIV originating from the wild-bird reservoir.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 459-463
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 36.

Tytuł:

Detection of the influenza virus yesterday and now

Autorzy:

Woźniak-Kosek, Agnieszka
Kempińska-Mirosławska, Bogumiła
Hoser, Grażyna

Powiązania:

https://bibliotekanauki.pl/articles/1039248.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

influenza
virus
detection method
diagnostics
PCR
viral respiratory tract infection

Opis:

Demographic changes and the development of transportation contribute to the rapid spread of influenza. Before an idea of a 'person to person' spread appeared, divergent theories were developed to explain influenza epidemics in the past. Intensified virological and serological tests became possible after isolation of the human influenza virus in 1933. The first influenza virus detection methods were based on its isolation in egg embryos or cell lines and on demonstration of the presence of the viral antigens. Molecular biology techniques associated with amplification of RNA improved the quality of tests as well as sensitivity of influenza virus detection in clinical samples. It became possible to detect mixed infections caused by influenza types A and B and to identify the strain of the virus. Development of reliable diagnostic methods enabled fast diagnosis of influenza which is important for choosing an appropriate medical treatment.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 465-470
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 37.

Tytuł:

Expression, purification and characterization of glycosylated influenza H5N1 hemagglutinin produced in Pichia pastoris

Autorzy:

Kopera, Edyta
Dwornyk, Angela
Kosson, Piotr
Florys, Katarzyna
Sączyńska, Violetta
Dębski, Janusz
Cecuda-Adamczewska, Violetta
Szewczyk, Bogusław
Zagórski-Ostoja, Włodzimierz
Grzelak, Krystyna

Powiązania:

https://bibliotekanauki.pl/articles/1039268.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Avian influenza
H5N1
recombinant hemagglutinin
Pichia pastoris

Opis:

The A/swan/Poland/305-135V08/2006 (H5N1-subtype) hemagglutinin (HA) gene was cloned and expressed in yeast Pichia pastoris (P. pastoris). The HA cDNA lacking the C-terminal transmembrane anchor-coding sequence was fused to an α-factor leader peptide and placed under control of the methanol-inducible P. pastoris alcohol oxidase 1 (AOX1) promoter. Two P. pastoris strains: SMD 1168 and KM 71 were used for protein expression. Recombinant HA protein was secreted into the culture medium reaching an approximately 15 mg/L (KM 71 strain). Fusion protein with a His6 tag was purified to homogeneity in one step affinity chromatography. SDS-PAGE and MS/MS analysis indicated that the protein is cleaved into HA1 and HA2 domains linked by a disulfide bond. Analysis of the N-linked glycans revealed that the overexpressed HA is fully glycosylated at the same sites as the native HA in the vaccine strain. Immunological activity of the hemagglutinin protein was tested in mice, where rHA elicited a high immune response.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 597-602
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 38.

Tytuł:

Antiviral activity of novel oseltamivir derivatives against some influenza virus strains

Autorzy:

Kocik, Janusz
Kołodziej, Marcin
Joniec, Justyna
Kwiatek, Magdalena
Bartoszcze, Michał

Powiązania:

https://bibliotekanauki.pl/articles/1039256.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

influenza virus
neuraminidase inhibitors
oseltamivir
antiviral activity
cytotoxicity

Opis:

The aim of this study was to investigate the in vitro cytotoxicity of oseltamivir derivatives and determine their activity against A/H1N1/PR/8/34 and A/H3N2/HongKong/8/68 - strains of influenza virus. Antiviral activity of these compounds was determined by using two methods. MTT staining was used to assess the viability of MDCK cells infected with influenza viruses and treated with various concentrations of drugs. In parallel, the effect of drugs on viral replication was assessed using the hemagglutination test. The most toxic compounds were: OS-64, OS-35, OS-29, OS-27 and OS-25, whereas OS-11, OS-20 and OS-23 were the least toxic ones. Statistically significant antiviral effect at a higher virus dose was shown by compounds: OS-11, OS-20, OS-27, OS-35, and OS-64. H3N2 virus was sensitive to 10-times lower concentrations of OS-11 and OS-35 than H1N1. At a lower infection dose, the antiviral activity was observed for OS-11, OS 27, OS-35 and OS-20. OS-64 turned out to be effective only at a high concentration. OS-23 showed no antiviral effect.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 509-513
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 39.

Tytuł:

Influenza prevention and treatment by passive immunization

Autorzy:

Kalenik, Barbara
Sawicka, Róża
Góra-Sochacka, Anna
Sirko, Agnieszka

Powiązania:

https://bibliotekanauki.pl/articles/1039265.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

antibody
clinical trials
hemagglutinin
influenza
neutralization
passive immunity

Opis:

Passive immunity is defined as a particular antigen resistance provided by external antibodies. It can be either naturally or artificially acquired. Natural passive immunization occurs during pregnancy and breast-feeding in mammals and during hatching in birds. Maternal antibodies are passed through the placenta and milk in mammals and through the egg yolk in birds. Artificial passive immunity is acquired by injection of either serum from immunized (or infected) individuals or antibody preparations. Many independent research groups worked on selection, verification and detailed characterization of polyclonal and monoclonal antibodies against the influenza virus. Numerous antibody preparations were tested in a variety of in vitro and in vivo experiments for their efficacy to neutralize the virus. Here, we describe types of antibodies tested in such experiments and their viral targets, review approaches resulting in identification of broadly neutralizing antibodies and discuss methods used to demonstrate their protective effects. Finally, we shortly discuss the phenomenon of maternal antibody transfer as a way of effective care for young individuals and as an interfering factor in early vaccination.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 573-587
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 40.

Tytuł:

Characterization of mAb6-9-1 monoclonal antibody against hemagglutinin of avian influenza virus H5N1 and its engineered derivative, single-chain variable fragment antibody

Autorzy:

Sawicka, Róża
Siedlecki, Paweł
Kalenik, Barbara
Radomski, Jan
Sączyńska, Violetta
Porębska, Anna
Szewczyk, Bogusław
Sirko, Agnieszka
Góra-Sochacka, Anna

Powiązania:

https://bibliotekanauki.pl/articles/1038689.pdf

Data publikacji:

2017

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

influenza virus
monoclonal antibody
scFv
hemagglutinin
antigenic epitope

Opis:

Hemagglutinin (HA), as a major surface antigen of influenza virus, is widely used as a target for production of neutralizing antibodies. Monoclonal antibody, mAb6-9-1, directed against HA of highly pathogenic avian influenza virus A/swan/Poland/305-135V08/2006(H5N1) was purified from mouse hybridoma cells culture and characterized. The antigenic specificity of mAb6-9-1 was verified by testing its cross-reactivity with several variants of HA. The mimotopes recognized by mAb6-9-1 were selected from two types of phage display peptide libraries. The comparative structural model of the HA variant used for antibody generation was developed to further facilitate epitope mapping. Based on the sequences of the affinity- selected polypeptides and the structural model of HA the epitope was located to the region near the receptor binding site (RBS). Such localization of the epitope recognized by mAb6-9-1 is in concordance with its moderate hemagglutination inhibiting activity and its antigenic specificity. Additionally, total RNA isolated from the hybridoma cell line secreting mAb6-9-1 was used for obtaining two variants of cDNA encoding recombinant single-chain variable fragment (scFv) antibody. To ensure high production level and solubility in bacterial expression system, the scFv fragments were produced as chimeric proteins in fusion with thioredoxin or displayed on a phage surface after cloning into the phagemid vector. Specificity and affinity of the recombinant soluble and phage-bound scFv were assayed by suitable variants of ELISA test. The observed differences in specificity were discussed.

Źródło:

Acta Biochimica Polonica; 2017, 64, 1; 85-92
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 41.

Tytuł:

Knowledge and compliance with recommendations for seasonal influenza vaccination among medical and dental students

Autorzy:

Kawalec, Anna

Powiązania:

https://bibliotekanauki.pl/articles/1178226.pdf

Data publikacji:

2018

Wydawca:

Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN

Tematy:

dental students
influenza vaccines
medical staff
medical students

Opis:

Vaccination against seasonal influenza is recommended for everyone older than 6 months. It is underlined, that healthcare workers and students may contribute to nosocomial influenza transmission, however, flu vaccination rate among medical stuff remains low. The aim of this study was the assessment of knowledge of flu vaccination recommendations and compliance with them among medical and dental students in conjunction with analysis of potential differences according to the type of faculty. The study was conducted from 10th to 16th October 2017 with the use of anonymous survey among 203 healthcare students of Wroclaw Medical University (131 medical students, 72 dentistry students). The questionnaire was divided into 3 sections: demographic data, vaccination status, knowledge of recommendations. Obtained data showed that declared vaccination rate in season 2016/2017 was 15.82%, and 13.92% in 2015/2016. Although we observed that influenza vaccination coverage was higher among dental students, the difference was statistically insignificant. Knowledge of recommendations was good, 78% of students knew, that influenza vaccination is recommended for healthcare workers, and 73% answered, that it also concerns healthcare students. Significant differences in identification of groups, for which flu vaccination is especially recommended, were observed. Dental students more frequently chose all correct answers (p-value 0,006). Also sources of knowledge differed (p-value 0,007), medical students more often declared using professional medical journals, while dental students more frequently indicated impact of family. Although the knowledge of recommendations for influenza vaccination is rather good among students, vaccination coverage remains low. Identification of gaps in students' knowledge and differences according to faculty, may suggest directions in which activities promoting regular vaccination against influenza should concentrate.

Źródło:

World Scientific News; 2018, 93; 50-59
2392-2192

Pojawia się w:

World Scientific News

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 42.

Tytuł:

Detection and differentiation of Newcastle disease virus and influenza virus by using duplex real-time PCR

Autorzy:

Nidzworski, Dawid
Wasilewska, Edyta
Smietanka, Krzysztof
Szewczyk, Bogusław
Minta, Zenon

Powiązania:

https://bibliotekanauki.pl/articles/1039554.pdf

Data publikacji:

2013

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Newcastle disease virus
influenza virus
detection
differentiation
real-time PCR
duplex

Opis:

Newcastle disease virus (NDV), member of the Paramyxoviridae family and avian influenza virus (AIV), member of the Orthomyxoviridae family, are two main avian pathogens causing serious economic problems in poultry health. Both are enveloped, single-stranded, negative-sense RNA viruses and cause similar symptoms, ranging from sub-clinical infections to severe diseases, including decrease in egg production, acute respiratory syndrome, and high mortality. Similar symptoms hinder the differentiation of infection with the two viruses by standard veterinary procedures like clinical examination or necropsy. To overcome this problem, we have developed a new duplex real-time PCR assay for the detection and differentiation of these two viruses. Eighteen NDV strains, fourteen AIV strains, and twelve other (negative control) strains viruses were isolated from allantoic fluids of specific pathogen-free (SPF), embryonated eggs. Four-weeks-old SPF chickens were co-infected with both viruses (NDV - LaSota and AIV - H7N1). Swabs from cloaca and trachea were collected and examined. The results obtained in this study show that by using duplex real-time PCR, it was possible to detect and distinguish both viruses within less than three hours and with high sensitivity, even in case a bird was co-infected. Additionally, the results show the applicability of the real-time PCR assay in laboratory practice for the identification and differentiation of Newcastle disease and influenza A viruses in birds.

Źródło:

Acta Biochimica Polonica; 2013, 60, 3; 475-480
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

/5

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Skocz do pozycji: 43.

Tytuł:

Antibody response to DNA vaccine against H5N1 avian influenza virus in broilers immunized according to three schedules

Autorzy:

Stachyra, Anna
Góra-Sochacka, Anna
Zagórski-Ostoja, Włodzimierz
Król, Ewelina
Sirko, Agnieszka

Powiązania:

https://bibliotekanauki.pl/articles/1039267.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Avian influenza
H5N1
DNA vaccine
broilers

Opis:

Broiler type chickens were immunized intramuscularly with a DNA vaccine encoding hemagglutinin (HA) from H5N1 avian influenza virus. The chickens were divided into four groups: control group which was not immunized, a group which obtained only one dose, and two groups which were immunized twice, one group with a boost two weeks after the priming and the other four weeks. Blood samples were collected at several time points and the dynamics of the humoral response to the vaccine was studied. High level of anti-HA antibodies was detected only in the last two groups, that is in chickens immunized according to the prime-boost strategy, regardless of the schedule. An additional interesting observation of this study was detection of the cross-reactivity of an anti-H5 HA positive serum with H5N2 and H1N1 viruses, suggesting that the DNA vaccine tested can induce antibodies of a broad specificity.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 593-596
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 44.

Tytuł:

Why Don’t Blanchard-Kahn ever "Catch" Flu? And How it Matters for Measuring Indirect Cost of Epidemics in DSGE Framework

Autorzy:

Torój, Andrzej

Powiązania:

https://bibliotekanauki.pl/articles/483327.pdf

Data publikacji:

2013

Wydawca:

Polska Akademia Nauk. Czytelnia Czasopism PAN

Tematy:

indirect cost
influenza
DSGE
Blanchard-Kahn conditions
modelling epidemics

Opis:

We attempt to apply a New Keynesian open economy model to simulate the economic consequences of influenza epidemic in Poland and measure the output loss (indirect cost) related to this disease. We introduce a negative health shock on the supply side of the economy and demonstrate that such a shock – implemented as a reduction in labour utilisation under unchanged labour cost – is not equivalent to negative labour supply shock. As expectational effects may hypothetically play a significant role in determining the economic cost of influenza, we attempt to endogenise the mechanism of epidemic in the model for the rational expectations solution algorithm to take account for the possibility of epidemic. This attempt has failed for the standard SIR model of epidemic and for the standard Blanchard-Kahn-like local solution methods, as the SIR block is only consistent with Blanchard-Kahn conditions under herd immunity of the population. In the deterministic simulation with the number of infected given exogenously, the output loss resulting from influenza-related presenteeism and absenteeism was estimated at 0.004% of the steady state level on average in the period 2000-2013. The simulated indirect cost in the New Keynesian model has turned out to be lower than the estimates that one could possibly obtain using the human capital approach. The reason for this discrepancy is the demand-oriented construction of the New Keynesian framework, and we treat this result as closer in notion to what the friction cost approach might suggest.

Źródło:

Central European Journal of Economic Modelling and Econometrics; 2013, 5, 3; 185-206
2080-0886
2080-119X

Pojawia się w:

Central European Journal of Economic Modelling and Econometrics

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 45.

Tytuł:

Szczepienia przeciwko grypie u personelu medycznego
Influenza vaccinations of health care personnel

Autorzy:

Nitsch-Osuch, Aneta
Brydak, Lidia B.

Powiązania:

https://bibliotekanauki.pl/articles/2168412.pdf

Data publikacji:

2014-10-29

Wydawca:

Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi

Tematy:

grypa
szczepienia ochronne
personel medyczny
influenza
vaccination
Health care workers

Opis:

Grypa jest jedną z częstszych infekcji dróg oddechowych, zachorowania na nią występują we wszystkich grupach wiekowych pacjentów na całym świecie. Liczba zachorowań na grypę sezonową i zgonów z powodu jej powikłań jest znaczna w skali globalnej. Szczepienia, również przeciwko grypie, są istotnym osiągnięciem medycyny ostatniego stulecia, jednak problemem pozostaje zwalczanie grypy za pomocą szczepień ochronnych wśród personelu medycznego. Szczepienie personelu medycznego jest procedurą o udowodnionym bezpieczeństwie i skuteczności, zapewnia zapobieganie zachorowaniom wśród pacjentów. Mimo licznych rekomendacji eksperckich stan zaszczepienia pracowników medycznych pozostaje niski. W celu zwiększenia liczby zaszczepionych pracowników medycznych konieczne jest prowadzenie kampanii edukacyjnych, które mają na celu polepszenie stanu wiedzy personelu na temat grypy, jej powikłań, szczepień przeciwko grypie, ze szczególnym uwzględnieniem ich bezpieczeństwa i skuteczności. Szczepieni pracownicy najczęściej decyzję o wykonaniu szczepienia motywują chęcią ochrony siebie oraz chęcią ochrony przed zakażeniem swoich pacjentów i ich rodzin. Z kolei wśród przyczyn nieszczepienia wymieniane są: brak czasu, błędne przekonania o nieskuteczności szczepienia, brak potrzeby szczepienia z powodu bagatelizowania choroby i jej powikłań, obawa przez niepożądanymi odczynami poszczepiennymi. Konieczne jest wdrożenie strategii mających na celu edukację personelu medycznego w zakresie stosowania szczepień przeciwko grypie w celu zwiększenia wyszczepialności przeciwko grypie w populacji pracowników medycznych. Med. Pr. 2013;64(1):119–129
Influenza is one of the most common respiratory diseases affecting people of all age groups all over the world. Seasonal influenza leads to substantial morbidity and mortality on a global scale. Vaccines are undeniably one of the most important health advances of the past century, however, managing influenza in working populations remains a difficult issue. Vaccination of health care workers (HCW) is an efficient way to reduce the risk of occupational infection and to prevent nosocomial transmission to vulnerable patients. Despite this, achieving high immunization rates among those professionals is a challenge. Knowledge and attitudes of healthcare providers have significant impact on the frequency with which vaccines are offered and accepted, but many HCWs are poorly equipped to make informed recommendations about vaccine merits and risks. Principal reasons for vaccination are the willing not to be infected and avoiding transmission to patients and the family. The main reasons for refusing is lack of time, a feeling of invulnerability to vaccination, conviction of not being at risk, of being too young or in good health. Misconceptions about influenza vaccine efficacy, like adverse effects, and fear of contracting illness from the vaccine are significantly associated with noncompliance with vaccination. Therefore, strategies to increase awareness of the importance of recommending influenza immunization among health professionals are required. Med Pr 2013;64(1):119–129

Źródło:

Medycyna Pracy; 2013, 64, 1; 119-129
0465-5893
2353-1339

Pojawia się w:

Medycyna Pracy

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 46.

Tytuł:

Introduction to molecular biology of influenza a viruses

Autorzy:

Szewczyk, Bogusław
Bieńkowska-Szewczyk, Krystyna
Król, Ewelina

Powiązania:

https://bibliotekanauki.pl/articles/1039236.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

Orthomyxoviridae
influenza A virus
virion structure
genome
entry
release
new polypeptides

Opis:

This minireview presents an overview of current knowledge on virion structure, genome organization and basic events in the development of influenza A virus. The processes of entry, transcription/replication and viral release are described. In this context, the roles of viral proteins (including recently discovered minor polypeptides) in the subsequent stages of viral development are also discussed.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 397-401
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 47.

Tytuł:

Structural biology of the influenza virus fusion peptide

Autorzy:

Worch, Remigiusz

Powiązania:

https://bibliotekanauki.pl/articles/1039239.pdf

Data publikacji:

2014

Wydawca:

Polskie Towarzystwo Biochemiczne

Tematy:

influenza virus
viral entry
membrane fusion
fusion peptide
peptide-lipid interactions

Opis:

The release of influenza RNA inside the host cell occurs through the fusion of two membranes, the viral envelope and that of the cellular endosome. The fusion is mediated by the influenza hemagglutinin protein (HA), in particular by the fusion peptide (HAfp) located in the N-terminal fragment of HA2 subunit. This protein fragment anchors in the internal endosomal membrane, whereas the C-terminal HA2 part comprises a transmembrane domain (TMD) embedded in the viral envelope. A drop of pH in the endosome acts as the main trigger for HA2 large conformational change that leads to anchoring of the fusion peptide, close contact of the membranes and the subsequent fusion. Throughout the years the major research effort was focused on a 20-aminoacid fragment (HAfp1-20), shown by NMR to adopt a 'boomerang'-like structure. However, recent studies showed that extending HAfp1-20 by three highly conserved residues W21-Y22-G23 leads to formation of a unique, tight helical hairpin structure. This review summarizes recently discovered structural aspects of influenza fusion peptides and their relations with the membrane fusion mechanism.

Źródło:

Acta Biochimica Polonica; 2014, 61, 3; 421-426
0001-527X

Pojawia się w:

Acta Biochimica Polonica

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 48.

Tytuł:

Zagrozenia zdrowotne zwiazane z wirusem ptasiej grypy
Health risks connected with the avian flu virus

Autorzy:

Brydak, L B

Powiązania:

https://bibliotekanauki.pl/articles/838455.pdf

Data publikacji:

2007

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

zagrozenia czlowieka
zagrozenia zdrowia
wirus influenzy ptakow
influenza ptakow
choroby zwierzat

Źródło:

Annals of Parasitology; 2007, 53, 2; 81-84
0043-5163

Pojawia się w:

Annals of Parasitology

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 49.

Tytuł:

Zagrożenia zdrowotne związane z wirusem ptasiej grypy
Health risks connected with the avian flu virus

Autorzy:

Brydak, L. B.

Powiązania:

https://bibliotekanauki.pl/articles/2143849.pdf

Data publikacji:

2007

Wydawca:

Polskie Towarzystwo Parazytologiczne

Tematy:

zagrozenia czlowieka
zagrozenia zdrowia
wirus influenzy ptakow
influenza ptakow
choroby zwierzat

Opis:

The first human cases of infections with entire avian influenza strain were caused by subtype A/H5N1/ and occurred in 1997 in Hong Kong. Since this year until 27 March 2007 World Health Organization confirmed over 370 human cases of infections with avian influenza and almost 160 persons died due to this pathogen. At present there is known that person to person transmission of avian influenza virus is limited. Nevertheless, it is possible that with time virus will adapt to human sufficiently to be able to cause next influenza pandemic. Despite intensive studies and global influenza surveillance there is no possible to predict when pandemic will begin and what kind of virus will cause this outbreak.

Źródło:

Wiadomości Parazytologiczne; 2007, 53, 2; 81-84
0043-5163

Pojawia się w:

Wiadomości Parazytologiczne

Dostawca treści:

Biblioteka Nauki

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Skocz do pozycji: 50.

Tytuł:

Szczepienia pracowników medycznych przeciw grypie – poziom zaszczepienia, determinanty, możliwości interwencji
Influenza vaccination in healthcare workers – vaccination coverage, determinants, possible interventions

Autorzy:

Jędrzejek, Michał J.
Mastalerz-Migas, Agnieszka

Powiązania:

https://bibliotekanauki.pl/articles/2081913.pdf

Data publikacji:

2021-06-30

Wydawca:

Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi

Tematy:

grypa
szczepienia
personel medyczny
bariery
motywy
postawy
influenza
vaccination
healthcare workers
barriers
motivators
attitudes

Opis:

Szczepienia przeciw grypie są zalecane każdego roku wszystkim pracownikom medycznym jako kluczowy element działań mających na celu m.in. zapobieganie transmisji grypy w placówkach opieki zdrowotnej. Biorąc pod uwagę to zalecenie oraz znaczenie takich szczepień, dokonano przeglądu niesystematycznego literatury, by ocenić kwestie związane z poziomem zaszczepienia, deklarowanymi motywami oraz barierami dotyczącymi szczepień, a także interwencjami, których celem jest zwiększenie wskaźnika szczepień w tej grupie zawodowej. Dane z dostępnych publikacji wskazują, że wskaźnik realizacji szczepień przeciw grypie wśród pracowników medycznych jest ogólnie niski i zróżnicowany w czasie, lokalnie, a także wśród poszczególnych zawodów medycznych. Głównym motywem szczepienia przeciw grypie jest chęć ochrony siebie i rodziny. Wśród licznych barier wymienia się najczęściej błędne przekonania dotyczące bezpieczeństwa i skuteczności szczepień oraz bariery organizacyjne. Wskazuje się, że jest duża potrzeba prowadzenia działań edukacyjnych oraz promocyjnych będących kluczowymi elementami zwiększania poziomu zaszczepienia w strategii dobrowolnych szczepień.
Influenza vaccination, as a key element of control activities intended, inter alia, to prevent nosocomial influenza transmission, is recommended each year for all healthcare workers (HCWs). Due to these recommendations and the importance of influenza vaccination among HCWs, a targeted literature review was conducted to assess issues related to vaccination coverage, declared motivators and barriers, as well as interventions to increase vaccination coverage in this professional group. Data obtained from the available publications implies that influenza vaccination rates among WHCs are universally low and vary over time as well as between regions and different types of healthcare professionals (physicians/nurses). One of the main determinants of influenza vaccine uptake is the desire to protect oneself and one’s family. On the other hand, practical considerations and misconceptions about the safety and effectiveness of vaccines are the most frequently mentioned preventative causes. There is an urgent need to implement well-organized educational campaigns as this is key to increasing vaccination rates as part of a non-mandatory vaccination strategy. Med Pr. 2021;72(3):305–19

Źródło:

Medycyna Pracy; 2021, 72, 3; 305-319
0465-5893
2353-1339

Pojawia się w:

Medycyna Pracy

Dostawca treści:

Biblioteka Nauki

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