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Tytuł:
Antivirals - current trends in fighting influenza
Autorzy:
Król, Ewelina
Rychłowska, Małgorzata
Szewczyk, Bogusław
Powiązania:
https://bibliotekanauki.pl/articles/1039254.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza virus
antivirals
novel anti-influenza drugs
antiviral therapy
inhibitors
Opis:
Influenza virus infection is a major source of morbidity and mortality worldwide. Due to the variable effectiveness of existing vaccines, especially in the early stages of an epidemic, antiviral drugs represent the first line of defense against the virus. Currently, there are two major classes of anti-influenza drugs approved by the FDA for clinical use: M2 protein inhibitors (amantadine and rimantadine) and neuraminidase inhibitors (zanamivir and oseltamivir). However, increasing resistance to these available influenza antivirals among circulating influenza viruses highlights the need to develop alternative approaches for the prevention and/or treatment of influenza. This review presents an overview of currently available drugs for influenza treatment as well as summarizes some new antiviral strategies that are now being tested covering agents targeting both the viral proteins and the host-virus interaction. We discuss their mechanisms of action, resistance and the therapeutic potential as new antiviral drug for use in future influenza pandemics. Additionally, combination therapy based on these drugs is also described.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 495-504
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Factors affecting decision concerning influenza vaccination among students of medical faculties
Autorzy:
Woźniak-Kosek, Agnieszka
Kempińska-Mirosławska, Bogumiła
Mendrycka, Mariola
Saracen, Agnieszka
Hoser, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1039225.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza
vaccination against influenza- knowledge
infections
students
Opis:
Influenza is one of the most common cyclic respiratory diseases in humans. Methods of prevention are multidirectional, but the most effective and most efficacious way to prevent influenza and its complications is through preventive vaccination. This work aims to determine different factors affecting the decision concerning influenza vaccine. The percentage of people vaccinated against the flu was evaluated, as well as their knowledge of post-influenza complications, etc. among full-time students and bridging studies of nursing and physiotherapy (full-time and part-time) at the University of Technology and Life Sciences in Radom, and students of medicine and pharmacy at the Medical University of Łódź. The research tool was the authors' questionnaire with 18 questions. The surveys conducted, consisting of multiple choice questions, were anonymous. In total, the survey involved 470 students. Overall, the number of people who were vaccinated against influenza in the 2012/13 epidemic season numbered 15 respondents, representing 5.84% of the total group of respondents. For the group of nursing students it was 6%, for physiotherapy students 5%, for students of medicine and pharmacy 14%. The percentage of respondents who said they would get vaccinated if the vaccinaton was free of charge was also low. Increasing the percentage of people vaccinated against influenza (immunization coverage) is a very important measure in preventing influenza epidemics. Therefore, it is necessary to identify the reasons why people are reluctant to be vaccinated against influenza, particularly among students who will work in the future in the health care services sector.
Źródło:
Acta Biochimica Polonica; 2014, 61, 4; 829-832
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Upper respiratory tract infections and influenza-like illnesses among healthcare workers: are serological tests useful in monitoring influenza and influenza-like illness?
Autorzy:
Toczek-Kubicka, Katarzyna
Szenborn, Filip
Kuchar, Ernest P.
Szenborn, Leszek
Powiązania:
https://bibliotekanauki.pl/articles/2153866.pdf
Data publikacji:
2022-12-29
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
IgM antibodies
vaccination
humoral response
influenza
healthcare workers
influenza-like illness
Opis:
Background Healthcare workers (HCWs) are at high risk for exposure to upper respiratory tract infections (URTIs) and influenza-like illnesses (ILIs). The present study aimed to surveil URTIs and ILIs and their impact among the Department of Pediatric Infectious Diseases in Wroclaw employees and evaluate their humoral response to influenza. Material and Methods Thirty-six HCWs participated in the first season and 32 HCWs in the second season during years of the study. The authors carried out a URTI/ILI surveillance, and all HCWs were asked to complete a weekly report during 2 influenza seasons: 2016/2017 (S1) and 2017/2018 (S2). In S1 both IgG and IgM antibodies against influenza A and B were assessed. The HCWs with symptoms of ILI were encouraged to undergo PCR tests for influenza. Results No significant differences in reporting URTI were found among vaccinated and non-vaccinated HCWs and HCWs and the control group. Depending on the year 5.5–17.2% of HCWs were treated with antibiotics because of URTI. In the study 58.7% of participants in S1 and 66.7% in S2 decide to work despite the URTI symptoms. There was no statistical relationship between the concentration of anti-influenza IgG and the number of URTIs and ILIs reported. Only vaccinated were willing to undergo voluntary influenza testing. Conclusions The URTI and ILI occur commonly in HCWs, and HCWs contract URTIs as often as the control group. Despite their medical education, HCWs work with the symptoms of infection and overuse antibiotics to treat the URTI. Serology testing is not able to follow the infection’s dynamics or identify the people immune to the influenza-like illness. The diagnostic value of IgM antibodies in acute influenza infection is negligible. Vaccinated HCWs are more focused on their health and are more willing to undergo influenza tests.
Źródło:
Medycyna Pracy; 2022, 73, 6; 441-447
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Szczepienia seniorów – profilaktyka chorób zakaźnych na przykładzie szczepienia przeciw grypie
Seniors vaccinations- prevention of contagious diseases on the ex ample of influenza vaccination
Autorzy:
Zawidzka, Magdalena
Nazar, Elżbieta
Kamińska, Marta
Przybylska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1029473.pdf
Data publikacji:
2018
Wydawca:
Państwowa Uczelnia Zawodowa we Włocławku
Tematy:
influenza
old age
vaccinations
Opis:
Introduction. Influenza has been known as the most common contagious disease attacking the respiratory system of patients at any age. In addition to influenza vaccination, older people are also advised to vaccinate against pneumonia, hepatitis (Hepatitis B), pertussis, diphtheria and tetanus. The aim of this work is to present the importance of influenza vaccination and senior participation in the "Program for the prevention of contagious diseases with respect to the use of influenza vaccination for people over 65", on the example of Włocławek, Lublin and Wrocław. Overview. Contagious diseases in older people are often characterized by a severe course and an increased risk of complications. Despite the wide-scale infection prevention among the older people, protective vaccinations are the most effective way to prevent influenza, as well as its complications. The number of vaccinated patients over 65 is low. The use of protective vaccinations has a beneficial effect not only on the health of patients, but also on the reduction of treatment costs associated with the occurrence of possible post-influenza complications and long-term hospitalization. Systematic influenza vaccinations are liekely to protect patients from infection and complications, but also stimulate the body's immune system to function properly. Conclusions. Despite the recommendations of health professionals , the popularity of vaccinations among people over 65 is very low. The most common reasons associated with resignation from vaccinations among seniors include: fear of complications associated with vaccination and lack of faith in its effectiveness. For this reason, it is extremely important to effectively promote influenza vaccinations among the elderly.
Wstęp. Grypa to choroba zakaźna układu oddechowego pojawiająca się najczęściej, niezależnie od wieku. Osobom starszym oprócz szczepienia przeciw grypie zaleca się szczepienia przeciw zapaleniu płuc, wirusowemu zapaleniu wątroby (WZW) typu B, krztuścowi, błonicy oraz tężcowi. Celem niniejszej pracy jest przedstawienie istoty szczepienia przeciwko grypie oraz udziału seniorów w „Programie profilaktyki chorób zakaźnych w zakresie szczepień ochronnych przeciw grypie dla osób powyżej 65 roku życia”, na przykładzie miast Włocławek, Lublin oraz Wrocław. Przegląd. Choroby zakaźne występujące u osób w podeszłym wieku często charakteryzują się ciężkim przebiegiem i zwiększonym ryzykiem powikłań. Pomimo szeroko ukierunkowanej prewencji infekcji wśród osób starszych, najbardziej efektywnym oraz najskuteczniejszym sposobem zapobiegania grypie, a także jej powikłaniom, są szczepienia ochronne. Stopień wyszczepienia pacjentów powyżej 65 roku życia jest niski. Stosowanie szczepień ochronnych ma korzystny wpływ nie tylko na zdrowie pacjentów, ale także na obniżenie kosztów leczenia związanych z wystąpieniem ewentualnych powikłań pogrypowych oraz długotrwałej hospitalizacji. Systematyczne powtarzanie szczepień przeciwko grypie pozwala nie tylko chronić przed infekcją oraz powikłaniami, ale także pobudza układ obronny organizmu do skutecznego działania. Wnioski. Pomimo zaleceń specjalistów, popularność szczepień wśród osób po 65 roku życia jest bardzo niska. Do najczęstszych przyczyn związanych z rezygnacją ze szczepień u seniorów należą: lęk przed powikłaniami związanymi ze szczepieniem oraz brak wiary w jego skuteczność. Z tego powodu niezwykle ważne jest efektywne promowanie szczepień przeciw grypie wśród osób w podeszłym wieku.
Źródło:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2018, 3, 3; 81-90
2451-1846
Pojawia się w:
Innowacje w Pielęgniarstwie i Naukach o Zdrowiu
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza viruses resistant to neuraminidase inhibitors
Autorzy:
Nitsch-Osuch, Aneta
Brydak, Lidia
Powiązania:
https://bibliotekanauki.pl/articles/1039255.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza
resistance
neuraminidase inhibitors
Opis:
Neuraminidase inhibitors (NAIs) are antiviral drugs for treatment and prophylaxis of influenza. By blocking the activity of the enzyme neuraminidase, NAIs prevent new viral particles from being released. The increasing use of NAIs brings into focus the risk of drug resistance arising to the class. There are three levels of antiviral resistance according to the way that resistance can be detected or inferred: genotypic, phenotypic and clinical resistance. For many years seasonal influenza viruses resistance to NAIs was low (0.33%). Recently, there has been described an increasing number of resistant seasonal influenza strains to oseltamivir (2% in adults, 5-18% in children). In 2007 there were published data describing 14% resistant to oseltamivir strains of influenza A/H1N1/ in Europe. Approximately 0.5-1.0% of influenza A/H1N1/pdm09 isolates are currently resistant to oseltamivir. The established markers of the resistance to oseltamivir were found in 2.4% of human and 0.8% of avian isolates of influenza A/H5N1/. It has been not observed a cross resistance among oseltamivir and zanamivir. NAIs resistance in influenza viruses is relative and despite its presence patients with resistant viruses may still benefit from receiving these antivirals. The response to treatment with antivirals remains the most important proof of antiviral effectiveness. The rational use of NAIs is essential to preserve the best choice for treatment and prophylaxis of seasonal, avian and pandemic influenza.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 505-508
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza virus hemagglutinin as a vaccine antigen produced in bacteria
Autorzy:
Sączyńska, Violetta
Powiązania:
https://bibliotekanauki.pl/articles/1039263.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
recombinant influenza hemagglutinin
recombinant influenza vaccine
subunit influenza vaccine
bacterial hemagglutinin
prokaryotic protein production
Opis:
Recombinant subunit vaccines based on hemagglutinin proteins produced in bacteria (bacterial HAs) are promising candidates for enhancing the supply of vaccines against influenza, especially for a pandemic. Over 20 years after the failure to obtain the antigen with native HA characteristics in the early 1980’s, there are increasing data on successful production of HA proteins in bacteria. The vast majority of bacterial HAs have been based on the HA1 subunit of HA expressed separately or as a component of conjugate vaccines, but those based on the ectodomain and the HA2 subunit have also been reported. The most of HAs have been efficiently expressed as insoluble aggregates called inclusion bodies. Refolded and purified proteins were extensively studied for structure, the ability to bind to sialic acid-containing receptors, antigenicity, immunogenicity and efficacy. The results from these studies contradict the view that glycosylation determines the correct structure of the hemagglutinin, as they proved that bacterial HAs can be valuable vaccine antigens when appropriate folding and purification methods are applied to rationally designed proteins. The best evidence for success in bacterial production of protective HA is that vaccines based on proprietary Toll-like Receptor (VaxInnate) and bacteriophage Qβ-VLPs (Cytos Biotechnology) technologies have been advanced to clinical studies.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 561-572
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pandemic Influenza Threat
Autorzy:
Kaudhry, Harish
Fangriya, Ruchita
Powiązania:
https://bibliotekanauki.pl/articles/1194041.pdf
Data publikacji:
2015
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
H5N1
human influenza
pandemic influenza
threat
Opis:
The threat of a human influenza pandemic has greatly increased over the past several years with the emergence of highly virulent avian influenza viruses, notably H5N1 viruses, which have infected humans in several Asian and European countries. Previous influenza pandemics have arrived with little or no warning, but the current widespread circulation of H5N1 viruses among avian populations and their potential for increased transmission to humans and other mammalian species may afford us an unprecedented opportunity to prepare for the next pandemic threat. The US Department of Health and Human Services is coordinating a national strategy to respond to an influenza pandemic that involves multiple agencies, including the Centers for Disease Control and Prevention, the Food and Drug Administration, and the National Institutes of Health (NIH). Within NIH, the National Institute of Allergy and Infectious Diseases (NIAID) conducts basic and clinical research to develop new vaccine technologies and antiviral drugs against influenza viruses. We describe recent research progress in preparing for pandemic influenza.
Źródło:
World Scientific News; 2015, 11; 80-96
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
In vivo reassortment of influenza viruses
Autorzy:
Urbaniak, Kinga
Markowska-Daniel, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1039242.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza A viruses
Opis:
The genetic material of influenza A virus consists of eight negative-sense RNA segments. Under suitable conditions, the segmented structure of the viral genome allows an exchange of the individual gene segments between different strains, causing formation of new reassorted viruses. For reassortment to occur, co-infection with two or more influenza virus strains is necessary. The reassortment is an important evolutionary mechanism which can result in antigenic shifts that modify host range, pathology, and transmission of the influenza A viruses. In this process, the influenza virus strain with epidemic and/or pandemic potential can be created. Cases of this kind were in 1957 (Asian flu), 1968 (Hong Kong flu) and recently in 2009 (Mexico). Viruses containing genes of avian, swine, and/or human origin are widespread around the world, for example the triple reassortant H1N1 virus causing the 2009 influenza pandemic in 2009 that has become a seasonal virus. The aim of the study is to present the mechanism of reassortment and the results of experimental co-infection with different influenza viruses.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 427-431
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vaccination against influenza in pregnant women
Autorzy:
Brydak, Lidia
Nitsch-Osuch, Aneta
Powiązania:
https://bibliotekanauki.pl/articles/1039266.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza
vaccination
pregnancy
Opis:
Pregnancy places otherwise healthy women at an increased risk of complications arising from an influenza infection. It is suggested that physiological changes such as immunological changes, increased cardiac output and oxygen consumption, as well as lung tidal volume might increase the susceptibility to influenza complications if infection occurs during pregnancy. Immunization of pregnant women against influenza is currently recommended in many countries and has been proven to be safe and effective in reducing rates and severity of the disease in vaccinated mothers and their children. Influenza vaccination is also cost-effective. Nevertheless, influenza vaccine coverage remains low in pregnant women. This might stem from the lack of healthcare workers' education, a feeling among the general public that influenza is not a serious disease and a failure of prenatal care providers to offer the vaccine. In order to protect pregnant women and infants from influenza related morbidity and mortality an educational programme targeting healthcare workers in charge of pregnant women should be implemented.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 589-591
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza vaccine efficacy in patients aged 60–75 years in the 2016/2017 season
Autorzy:
Sławin, Agata
Brydak, Lidia
Doniec, Zbigniew
Mastalerz-Migas, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/552677.pdf
Data publikacji:
2018
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
influenza
human
vaccination
aged
immunization
Źródło:
Family Medicine & Primary Care Review; 2018, 3; 263-266
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Zakażenia wirusem grypy typu A u gołębi
Influenza A virus infections of pigeons
Autorzy:
Abolnik, Celia
Powiązania:
https://bibliotekanauki.pl/articles/22016002.pdf
Data publikacji:
2020
Wydawca:
Krajowa Izba Lekarsko-Weterynaryjna
Tematy:
ptaki
wirus influenzy A
epidemiologia
gołębie
choroby zwierząt
influenza ptaków
avian influenza
epidemiology
pigeons
Opis:
Influenza A viruses of all subtypes, in their low pathogenic state, form part of the natural microbiota of water bird species. Four intercontinental transmission waves of Goose/Guangdong H5 lineage viruses swept the globe since 2005, each characterized by epidemics in poultry and contact transmission to humans. A significant shift in ecology of avian influenza had occurred. The risks that columbids pose in the ecology and epidemiology of AI have been thoroughly investigated over the course of several decades. Cumulatively, the studies on free-living pigeons, market pigeons and those experimentally infected with LPAI and HPAI demonstrated, that pigeons were of no epidemiological significance in the transmission and spread of HPAI to humans.
Źródło:
Życie Weterynaryjne; 2020, 95, 06; 362-364
0137-6810
Pojawia się w:
Życie Weterynaryjne
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Seasonal influenza vaccination of healthcare workers: a narrative review
Autorzy:
Jędrzejek, Michał J.
Mastalerz-Migas, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/2084883.pdf
Data publikacji:
2022-04-11
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
infection control
influenza
healthcare facilities
healthcare workers
healthcare personnel
influenza vaccination
Opis:
Influenza is an acute respiratory disease caused by the influenza virus which often occurs in outbreaks and epidemics worldwide. The World Health Organization recommends annual vaccination of healthcare workers (HCWs) against influenza, because most of them are involved in the direct care of patients with a high risk of influenza-related complications. Given the significance of the disease burden, a targeted literature review was conducted to assess issues related to influenza vaccination among HCWs. The primary aim of this review was to assess the incidence of influenza among medical personnel and healthcare-associated influenza, and to outline the benefits of influenza vaccination for patients and HCWs themselves. Vaccination of HCWs seems to be an important strategy for reducing the transmission of influenza from healthcare personnel to their patients and, therefore, for reducing patient morbidity and mortality, increasing patient safety, and reducing work absenteeism among HCWs. The benefits of influenza vaccination for their patients and for HCWs themselves are addressed in literature, but the evidence is mixed and often of low-quality.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2022, 35, 2; 127-139
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hemagglutinin stalk domain from H5N1 strain as a potentially universal antigen
Autorzy:
Uranowska, Karolina
Tyborowska, Jolanta
Jurek, Anna
Szewczyk, Bogusław
Gromadzka, Beata
Powiązania:
https://bibliotekanauki.pl/articles/1039261.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
H5N1
universal influenza antigen
hemagglutinin stalk domain
universal influenza antibodies
FI6
Opis:
Influenza A virus infections are the major public health concern and cause significant morbidity and mortality each year worldwide. Vaccination is the main strategy of influenza epidemic prevention. However, seasonal vaccines induce strain-specific immunity and must be reformulated annually based on prediction of the strains that will circulate in the next season. Thus, it is essential to develop vaccines that would induce broad and persistent immunity to influenza viruses. Hemagglutinin is the major surface antigen of the influenza virus. Recent studies revealed the importance of HA stalk-specific antibodies in neutralization of different influenza virus strains. Therefore, it is important to design an immunogen that would focus the immune response on the HA stalk domain in order to elicit neutralizing antibodies. In the present study, we report characterization of a conserved truncated protein, potentially a universal influenza virus antigen from the H5N1 Highly Pathogenic Avian Influenza A virus strain. Our results indicate that exposure of the HA stalk domain containing conserved epitopes results in cross reactivity with different antibodies (against group 1 and 2 HAs). Additionally, we conclude that HA stalk domain contains not only conformational epitopes recognized by universal FI6 antibody, but also linear epitopes recognized by other antibodies.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 541-550
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
ReCOMmendations for the treatment of INFLUENZA in children for Primary care physiciAnS – COMPAS INFLUENZA
Autorzy:
Doniec, Zbigniew
Mastalerz-Migas, Agnieszka
Jackowska, Teresa
Kuchar, Ernest
Sybilski, Adam
Powiązania:
https://bibliotekanauki.pl/articles/552248.pdf
Data publikacji:
2019
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
influenza
children
treatment
vaccinations.
Opis:
Influenza is an acute infectious disease of the airways that occurs in every age group. The course of the disease may have a different severity and clinical picture, from asymptomatic to severe with symptoms of respiratory failure. The possibilities of pandemic infections and serious complications throughout the course of influenza distinguish it from other viral respiratory diseases, prompting us to treat it in a special way. Diagnosis of the disease is usually clinical in nature, and additional studies may be helpful in clinically relevant cases. The drug recommended for treatment and chemoprophylaxis is oseltamivir. Clinical benefits are greatest if treatment starts as early as possible, within 48 hours of the first symptoms of influenza. Clinical studies indicate that early treatment with oseltamivir may shorten the duration of the disease and reduce the risk of its complications. Annual influenza vaccination is the most effective method of preventing this disease, and the only contraindication to vaccination is the occurrence of an anaphylactic or other severe allergic reaction after a previous vaccination
Źródło:
Family Medicine & Primary Care Review; 2019, 2; 189-198
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Testing of human specimens for the presence of highly pathogenic zoonotic avian influenza virus A [H5N1] in Poland in 2006-2008 - justified or unnecessary steps?
Autorzy:
Romanowska, M
Nowak, I.
Brydak, L.B.
Wojtyla, A.
Powiązania:
https://bibliotekanauki.pl/articles/50626.pdf
Data publikacji:
2009
Wydawca:
Instytut Medycyny Wsi
Tematy:
avian influenza virus type A
zoonosis
influenza
H5N1 subtype
avian influenza
disease outbreak
diagnostic test
Polska
Źródło:
Annals of Agricultural and Environmental Medicine; 2009, 16, 2; 239-247
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
A clinical utility of a strip test for influenza A/B and comparison with detection by RT PCR
Autorzy:
Miarka, Maciej
Horban, Andrzej
Maliszewska, Henryka
Biliński, Przemysław
Prus-Kowalczuk, Wanda
Powiązania:
https://bibliotekanauki.pl/articles/1039251.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
A/H1N1/v influenza virus
strip test
influenza RT PCR
Opis:
Introduction and objective: In June 2009 the World Health Organization announced influenza pandemic caused by A/H1N1/v virus. It became crucial to recognize new cases of A/H1N1/v infection. An effective screening diagnostic procedure was needed for patients suffering from influenza-like symptoms for making an initial diagnosis and analyzing epidemiological pattern of infection. We used a strip test for influenza A/B as a screening diagnostic procedure for patients suffering from influenza-like symptoms for making an initial diagnosis. For comparison, RT PCR for detecting A/H1N1/v was performed. The aim of this study was to assess the efficacy and sensitivity of the strip test and its value for making initial diagnosis of influenza A/H1N1/v. Material and methods: Strip testing for the influenza A/B infection was performed on 1123 patients with influenza-like symptoms in the Admission Unit of the Regional Infectious Diseases Hospital in Warsaw. Strip test results were analyzed according to the age of patients and season of the year. For 97 patients strip test results for detecting A/H1N1 infection were compared with those obtained by RT PCR. Results: There were no statistically significant differences found between the methods and strip testing demonstrated sensitivity of 61% and specificity of 71%. Conclusions: No statistically significant differences were found between the two methods, however, strip test had low sensitivity and specificity.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 485-487
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza vaccination among healthcare workers – realization, promotion
Autorzy:
Tomaszewski, Mateusz
Łuniewski, Michał
Kulczyński, Marcin
Olender, Alina
Powiązania:
https://bibliotekanauki.pl/articles/1179527.pdf
Data publikacji:
2017
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Vaccines
healthcare workers
infectious disease prevention
influenza
Opis:
Influenza vaccination is the most important component of prevention of occurring and spreading of this disease. 80% vaccination coverage of healthcare personnel provides a substantial reduction of transmission; each and every next vaccinated person results in a decrease of morbidity, especially amongst elder or immunocompromised patients. In the analyzed studies most common reasons of insufficient vaccination coverage among healthcare workers were fear of side effects, lack of knowledge, conviction of vaccine inefficiency, lack of feeling of social responsibility, and inadequate accessibility of vaccine. Healthcare workers who were vaccinated regularly did it mostly in order to provide safety to themselves, their relatives and patients; they did it also due to the knowledge of vaccination efficiency. The most effective actions to improve vaccination coverage were: vaccination requirement by the employer, active encouragement, effective promotion, better vaccine accessibility and promotion of vaccination as prosocial behavior. Offering surgical masks as an alternative did not improve vaccination rate in most analyzed studies. In conclusion, most important reasons of declining influenza vaccination by healthcare workers are lack of knowledge and low accessibility of vaccination, so evidently education, promotion and facilitating the vaccination in workplace are the most effective ways causing the growth of vaccination rate.
Źródło:
World Scientific News; 2017, 76; 50-59
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The impact of selected educational and information interventions on the coverage rate and attitudes to influenza vaccination in nursing staff
Autorzy:
Gołębiak, Izabela
Okręglicka, Katarzyna
Kanecki, Krzysztof
Nitsch-Osuch, Aneta
Powiązania:
https://bibliotekanauki.pl/articles/2087444.pdf
Data publikacji:
2020-12-03
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
education
vaccination
influenza
attitude
nursing staff
intervention
Opis:
BackgroundInfluenza vaccinations are recommended for medical staff as an effective and safe form of preventing influenza and its complications. The aim of the study was to assess the impact of selected educational and information interventions on the influenza vaccination coverage (IVC) in nursing personnel and their attitude towards this procedure.Material and MethodsThe study participants (N = 320) were randomly divided into 4 groups. Group 1 participated in stationary training, whereas group 2 participated in distance learning. Additionally, 2 subgroups were established in each of the groups above: 1 subgroup received a reminder about the vaccination in the form of a short text message, and the other group did not receive any such reminder. The IVC rate in each group was determined; the attitude towards influenza vaccination was measured using the health belief model.ResultsThe highest IVC was obtained after stationary training followed by a reminder in the form of a short test message (36%). The reminder significantly affected IVC in the group attending stationary training (p < 0.05, OR = 2.5, 95% CI: 1.16–5.58); however, it had no impact on the IVC in the group participating in distance learning (p > 0.05, OR = 1.2, 95% CI: 0.51–2.83). Both stationary training and distance learning positively influenced the attitude towards influenza vaccinations. A major change in attitudes towards influenza vaccinations was observed only in the case of stationary training followed by a reminder in the form of a short text message (positive changes in perceived susceptibility and severity took place, perceived vaccination benefits increased, and perceived barriers were reduced).ConclusionsStationary training followed by a reminder in the form of a short text message is more effective in increasing the IVC rate compared to distance learning. It also promotes positive changes in attitudes to this prophylactic procedure, which is why it should be recommended for wider implementation.
Źródło:
Medycyna Pracy; 2020, 71, 6; 665-685
0465-5893
2353-1339
Pojawia się w:
Medycyna Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the knowledge, attitudes and behavior of healthcare workers concerning influenza vaccination in a training and research hospital in Türkiye
Autorzy:
Apaydin, Mehmet
Dogan, Serap
Aypak, Cenk
Powiązania:
https://bibliotekanauki.pl/articles/40570856.pdf
Data publikacji:
2024-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
attitude
behavior
healthcare workers
influenza vaccine
knowledge
Opis:
Introduction and aim. Although increasing vaccination rates among healthcare workers (HCWs) is crucial for protecting their own health and preventing the spread of infections to patients, vaccination rates remain low. The purpose of this study is to evaluate the knowledge, attitudes, and behavior of healthcare workers concerning seasonal influenza vaccination in a training and research hospital in Türkiye. Material and methods. This cross-sectional descriptive study was conducted among 364 healthcare workers working in a training and research hospital in Ankara, Türkiye. A face-to-face questionnaire was completed by selected participants that included questions about their sociodemographic characteristics, receiving seasonal influenza vaccination, reasons for not receiving vaccination, attitudes and behavior towards seasonal influenza vaccination recommendations for their surroundings, knowledge of who should get the vaccine, and their immunization history. Results. Among the participants, 58.5% stated that they had never received an influenza vaccination, 35.7% mentioned not receiving the regular influenza vaccination, and only 5.8% reported receiving the influenza vaccination regularly every year. Reasons for not getting vaccinated included not trusting the influenza vaccine’s protection (60.1%), not believing they are in the risk group (38.9%), and not finding a suitable time to get vaccinated (36.1%). A total of 57.1% of the healthcare workers recommended the influenza vaccine for their surroundings. Conclusion. Influenza vaccination rates among healthcare workers are quite low. To maximize influenza vaccine uptake, awareness programs are needed to correct the misconceptions health care workers have about the vaccine, and diverse strategies should be implemented to encourage them to get vaccinated, thereby promoting influenza vaccination.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 2; 313-319
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influenza A viruses of avian origin circulating in pigs and other mammals
Autorzy:
Urbaniak, Kinga
Kowalczyk, Andrzej
Markowska-Daniel, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/1039243.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
influenza A viruses
hemagglutinin
neuraminidase
Opis:
Influenza A viruses (IAVs) are zoonotic agents, capable of crossing the species barriers. Nowadays, they still constitute a great challenge worldwide. The natural reservoir of all influenza A viruses are wild aquatic birds, despite the fact they have been isolated from a number of avian and mammalian species, including humans. Even when influenza A viruses are able to get into another than waterfowl population, they are often unable to efficiently adapt and transmit between individuals. Only in rare cases, these viruses are capable of establishing a new lineage. To succeed a complete adaptation and further transmission between species, influenza A virus must overcome a species barrier, including adaptation to the receptors of a new host, which would allow the virus-cell binding, virus replication and, then, animal-to-animal transmission. For many years, pigs were thought to be intermediate host for adaptation of avian influenza viruses to humans, because of their susceptibility to infection with both, avian and human influenza viruses, which supported hypothesis of pigs as a 'mixing vessel'. In this review, the molecular factors necessary for interspecies transmission are described, with special emphasis on adaptation of avian influenza viruses to the pig population. In addition, this review gives the information about swine influenza viruses circulating around the world with special emphasis on Polish strains.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 433-439
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Diversity of influenza-like illness etiology in Polish Armed Forces in influenza epidemic season
Autorzy:
Kocik, Janusz
Niemcewicz, Marcin
Winnicka, Izabela
Michalski, Aleksander
Bielawska-Drózd, Agata
Kołodziej, Marcin
Joniec, Justyna
Cieślik, Piotr
Graniak, Grzegorz
Mirski, Tomasz
Gaweł, Jerzy
Bielecka-Oder, Anna
Kubiak, Leszek
Russell, Kevin
Powiązania:
https://bibliotekanauki.pl/articles/1039252.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
Influenza
ILI
surveillance
Polish Army
Opis:
The aim of this study was to conduct an epidemiological and laboratory surveillance of Influenza-Like Illnesses (ILI) in Polish Armed Forces, civilian military personnel and their families in 2011/2012 epidemic season, under the United States Department of Defense-Global Emerging Infections Surveillance and Response System (DoD-GEIS). ILI incidence data were analyzed in relation to age, gender, patient category as well as pathogen patterns. Multiple viral, bacterial and viral-bacterial co-infections were identified. Nose and throat swabs of active duty soldiers in the homeland country and in the NATO peacekeeping forces KFOR (Kosovo Force), as well as members of their families were tested for the presence of viral and bacterial pathogens. From October 2011 to May 2012, 416 specimens from ILI symptoms patients were collected and analyzed for the presence of viral and bacterial pathogens. Among viruses, coronavirus was the most commonly detected. In the case of bacterial infections, the most common pathogen was Staphylococcus aureus.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 489-494
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Opinions and behavior of family doctors concerning vaccinating against influenza
Autorzy:
Gutknecht, Piotr
Winiarski, Tomasz
Trzeciak, Bartosz
Molisz, Andrzej
Pietrzykowska, Małgorzata
Nowicka-Sauer, Katarzyna
Siebert, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/552798.pdf
Data publikacji:
2016
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
vaccination
influenza
family doctor
questionnaire
health care
employees.
Źródło:
Family Medicine & Primary Care Review; 2016, 3; 241-243
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
DNA vaccines against influenza
Autorzy:
Stachyra, Anna
Góra-Sochacka, Anna
Sirko, Agnieszka
Powiązania:
https://bibliotekanauki.pl/articles/1039258.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
DNA vaccine
influenza
hemagglutinin
immunization
adjuvant
cross-protection
Opis:
Genetic vaccine technology has been considerably developed within the last two decades. This cost effective and promising strategy can be applied for therapy of cancers and for curing allergy, chronic and infectious diseases, such as a seasonal and pandemic influenza. Despite numerous advantages, several limitations of this technology reduce its performance and can retard its commercial exploitation in humans and its veterinary applications. Inefficient delivery of the DNA vaccine into cells of immunized individuals results in low intracellular supply of suitable expression cassettes encoding an antigen, in its low expression level and, in turn, in reduced immune responses against the antigen. Improvement of DNA delivery into the host cells might significantly increase effectiveness of the DNA vaccine. A vast array of innovative methods and various experimental strategies have been applied in order to enhance the effectiveness of DNA vaccines. They include various strategies improving DNA delivery as well as expression and immunogenic potential of the proteins encoded by the DNA vaccines. Researchers focusing on DNA vaccines against influenza have applied many of these strategies. Recent examples of the most successful modern approaches are discussed in this review.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 515-522
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Plant expression systems for production of hemagglutinin as a vaccine against influenza virus
Autorzy:
Redkiewicz, Patrycja
Sirko, Agnieszka
Kamel, Katarzyna
Góra-Sochacka, Anna
Powiązania:
https://bibliotekanauki.pl/articles/1039262.pdf
Data publikacji:
2014
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
recombinant hemagglutinin
avian influenza
plant-produced
VLP
ELISA
Opis:
Many examples of a successful application of plant-based expression systems for production of biologically active recombinant proteins exist in the literature. These systems can function as inexpensive platforms for the large scale production of recombinant pharmaceuticals or subunit vaccines. Hemagglutinin (HA) is a major surface antigen of the influenza virus, thus it is in the centre of interests of various subunit vaccine engineering programs. Large scale production of recombinant HA in traditional expression systems, such as mammalian or insect cells, besides other limitations, is expensive and time-consuming. These difficulties stimulate an ever-increasing interest in plant-based production of this recombinant protein. Over the last few years many successful cases of HA production in plants, using both transient and stable expression systems have been reported. Various forms of recombinant HA, including monomers, trimers, virus like particles (VLPs) or chimeric proteins containing its fusion with other polypeptides were obtained and shown to maintain a proper antigenicity. Immunizations of animals (mice, ferrets, rabbits or chickens) with some of these plant-derived hemagglutinin variants were performed, and their effectiveness in induction of immunological response and protection against lethal challenge with influenza virus demonstrated. Plant-produced recombinant subunit vaccines and plant-made VLPs were successfully tested in clinical trials (Phase I and II) that confirmed their tolerance and immunogenicity.
Źródło:
Acta Biochimica Polonica; 2014, 61, 3; 551-560
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wybrane zioła w prewencji i wspomaganiu leczenia wirusowych infekcji dróg oddechowych
Selected herbs in the prevention and treatment of viral respiratory infections
Autorzy:
Siudem, Paweł
Powiązania:
https://bibliotekanauki.pl/articles/2138924.pdf
Data publikacji:
2022-08-01
Wydawca:
Wydawnictwo Naukowe Medyk sp. z o.o.
Tematy:
grypa
COVID-19
substancje roślinne
influenza
natural products
Opis:
Każdego roku w sezonie przeziębień i grypy obserwuje się wzrost zachorowań na wirusowe infekcje dróg oddechowych oraz inne choroby wirusowe. Podstawowym sposobem zapobiegania chorobom wirusowym są szczepienia. Nie zawsze jednak możliwe jest przyjęcie szczepienia bądź odporność po pewnym czasie wygasa. Wsparciem zarówno w zapobieganiu, jak i leczeniu mogą być liczne surowce roślinne. W tym artykule przedstawiono przegląd kilku wybranych surowców roślinnych, głównie skupiając się na ich wpływie na grypę i infekcję koronawirusem COVID-19.
Every year, during the cold and flu season, an increase in the incidence of viral respiratory infections and other viral diseases is observed. Vaccination is the primary method of preventing viral diseases. However, it is not always possible to be vaccinated, or the immunity expires after some time. Numerous plant materials can support both prevention and treatment. This article provides an overview of a few selected plant materials, mainly focusing on their impact on influenza and COVID-19 infection.
Źródło:
Lek w Polsce; 2022, 375, 07-08; 13-20
2353-8597
Pojawia się w:
Lek w Polsce
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-25 z 74

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