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Wyświetlanie 1-10 z 41
Tytuł:
Primary breast angiosarcoma – a case report
Autorzy:
Ostańska, Elżbieta
Aebisher, David
Kaznowska, Ewa
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/2040145.pdf
Data publikacji:
2020-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
breast biopsy histopathological examination
immunohistochemistry
Opis:
Introduction. Angiosarcoma is a rare breast cancer that can be primary or secondary after surgery or after breast cancer radiotherapy. It is important that breast angiosarcoma belongs to tumors with a non-specific clinical and radiological picture. Aim. The study of the biopsies contained aggressive vasomotor hyperplasia. Description of the case. The presented case concerns the primary angiosarcoma of the right breast in a 56-year-old woman who had never had a surgical procedure before, nor radiotherapy in the area of the breast. Conclusion. Histopathological examination supported by immunohistochemistry is a reliable and indispensable diagnostic element in the diagnosis of vascular sarcoma.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 4; 331-334
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Epidemiological profile and distribution of prognostic factors in invasive breast cancer among Algerian women
Autorzy:
Elbasyouni, Amel
Saadi, Leila
Baha, AbdelKarim
Powiązania:
https://bibliotekanauki.pl/articles/2047226.pdf
Data publikacji:
2021-09-22
Wydawca:
Medical Education
Tematy:
breast cancer
epidemiology
biomarkers
immunohistochemistry
prognostic
Opis:
Although the widespread of early screening and advanced medical therapies, the breast cancer incidence rate continues to rise among Algerian women. This retrospective study investigated mammary lesions’ epidemiological profile and histopathological characteristics and evaluated primary invasive breast cancer prognostic factors. We found that the incidence of breast cancer increases in middle- aged women between 40 and 60 years. Scarff Bloom Richardson grade II predominates in invasive breast cancer samples. In this study, molecular profiling shows that 82.1% of invasive tumours are hormone receptor-positive. A significant correlation is observed between the age of the patient and the SBR grade (p = 0.001) and with the hormone receptor expression (p = 0.001). In addition, the tumour grade is significantly correlated to oestrogen and progesterone receptor expression (p = 0.000; p = 0.000, respectively). Twenty-two per cent of cases were human epidermal growth factor receptor 2-positive. The Ki-67 proliferation index is expressed in 91% of breast cancer patients and was significantly associated with Scarff Bloom Richardson grade (p = 0.030), the progesterone receptor expression (p = 0.029) and with human epidermal growth factor receptor 2-positivity (p = 0.023). Primary breast cancer with a high grade is more frequent (31%) in young women under 40 years old, presenting 17% of our population. In summary, breast cancer patients in Algeria develop an unfavourable profile. Immunohistochemistry assay has played a pivotal role in assessing breast cancer predictive biomarkers improving the tumour behaviour and response to treatment.
Źródło:
OncoReview; 2021, 11, 4; 95-101
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The inflammatory reaction and the expression of pro- and anti-inflammatory cytokines to a novel polyester-polyurethane aortic prosthesis evaluated in dog sat 6 and 12 months post-implantation
Autorzy:
Mālniece, A.
Auzāns, A.
Powiązania:
https://bibliotekanauki.pl/articles/2087649.pdf
Data publikacji:
2018
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
polyester
polyurethane
inflammation
immunohistochemistry
aortic prosthesis
Źródło:
Polish Journal of Veterinary Sciences; 2018, 21, 4; 655-664
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Protective effectiveness of anise against testicular ischemia and reperfusion injury: An experimental study in rats
Autorzy:
Yildizhan, E.
Akkus, M.
Ulger, B.V.
Asır, F.
Söker, S.
Gündüz, E.
Rençber, M.
Barçin, M.
Powiązania:
https://bibliotekanauki.pl/articles/16647584.pdf
Data publikacji:
2023
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
Anise
testicle
ischemia
reperfusion
immunohistochemistry
Opis:
Testicular torsion is a frequently encountered clinical condition that requires urgent treatment. The aim of this study is to investigate the efficacy of Anise (Pimpinella anisum L.) in treating the pathological condition due to ischemia and reperfusion injury by using biochemical, histopathological and immunohistochemical methods. A total of 6 groups were formed with 8 male Wistar Albino rats in each group. Group 1 (n=8): control group, Group 2 (n=8): Anise aqueous solution was given orally 5 ml/kg by gavage for 30 days. Group 3 (n=8): Ischemia and Reperfusion (I/R) group, bilateral testicles were rotated 270° and reperfused after 30 minutes of ischemia. Group 4 (n=8): I/R+ Anise group, Group 5 (n=8): Anise+ I/R group and Group 6 (n=8): Anise+ I/R+ Anise group. The results of the Anise group and the Control group were similar. However, the damage in the I/R group was considerably more severe than in any of the other study groups. While it was observed that spermatogenic cells started to regenerate in the I/R+Anise group, edema and congestion were observed in the Anise+I/R group. In the Anise+I/R+Anise group, all histological findings and biochemical parameters were similar to those of the control group. It was observed that anise had protective effects in ischemia and reperfusion injury in rat testicles.
Źródło:
Polish Journal of Veterinary Sciences; 2023, 26, 2; 249-255
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical evaluation of the influence of L-arginine on biomarkers of environmental (cellular) stress in the kidneys of pregnant female rats
Autorzy:
Pedrycz, Agnieszka
Siermontowski, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/989964.pdf
Data publikacji:
2017
Wydawca:
Instytut Medycyny Wsi
Tematy:
nitric oxide
cellular stress
kidneys
pregnancy
immunohistochemistry
Opis:
Introduction. Kidney damage during pregnancy constitutes a diagnostic and therapeutic challenge. However, it is not entirely known whether a kidney condition recognised before the pregnancy releases an organism’s response to pregnancy, or whether pregnancy itself worsens kidney function. Objective. The aim of the study was immunohistochemical evaluation of cells of kidneys of pregnant rats under the influence of nitric oxide (NO), with measurement of the immunoexpression of cellular stress markers (p-53, HSP 70). The dose of administered L-arginine (NO substrate) was approximated to that applied in obstetrics in gestosis prevention and treatment in pregnant women. Materials and method. 60 female rats used in experiment were divided into 6 groups: 3 experimental and 3 control. The females from experimental groups were administered L-arginine (40g/kg, per os) every other day starting from the seventh day or pregnancy. The animals were decapitated on the 10th, 20th day of pregnancy, and 10 days after the delivery. Kidneys taken from decapitated rats were evaluated using the immunohistochemical three step method. HSP 70 and p-53 proteins were detected. Conclusions. L-arginine increased the expression of p-53 protein – on the 10th day of pregnancy, which increased at the end of pregnancy; however, 10 days after delivery the level dropped below that observable during physiological pregnancy. Hormonal changes in physiological pregnancy cause an increase in expression of the p-53 (cell stress marker) in the epithelial cells of renal tubules, mainly at the end of pregnancy (20th day). 10 days after the delivery, this expression decreases. The expression of HSP-70 protein increases already on the 10th day of pregnancy and maintains a similar level throughout the pregnancy, but is reduced after the puerperium.
Źródło:
Annals of Agricultural and Environmental Medicine; 2017, 24, 1
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Significance of mucin expression in pancreatic intraepithelial neoplasia (PanIN) – precursor lesions of pancreatic ductal adenocarcinoma (PDAC)
Autorzy:
Zińczuk, J.
Zaręba, K.
Pryczynicz, A.
Kuczyńska, P.
Boroń, Z.
Ustymowicz, W.
Maciorkowska, M.
Ćwiklińska-Dworakowska, M.
Baszun, M.
Jelski, S.
Guzińska-Ustymowicz, K.
Powiązania:
https://bibliotekanauki.pl/articles/1918638.pdf
Data publikacji:
2018-06-18
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Mucin
immunohistochemistry
pancreatic intraepithelial neoplasia
PanIN
Opis:
Purpose: To evaluate chosen mucins (mucin 1, 4, 5AC) expression in pancreatic intraepithelial neoplasia, which is a precursor lesion of pancreatic ductal adenocarcinoma. Materials and methods: The study group included 70 patients operated on due to inflammation, cysts and pancreatic ductal adenocarcinoma with pancreatic intraepithelial neoplasia revealed additionally. Mucin 1, 4 and 5AC expression was assessed by immunohistochemical method using polyclonal antibodies. Results: Statistical analysis proved a positive correlation between the expression of mucin 1, 4 and 5AC proteins and the presence and staging of pancreatic intraepithelial neoplasia (p<0.001). Statistically significant correlations were determined between mucin 1, 4 and 5AC and the location of PanIN lesion in the pancreas. Positive correlations were found between mucin 5AC expression and the type of a basic disease (p=0.014). Differences in the expression of MUC 1, 4 and 5AC proteins between healthy pancreatic ducts and various stages of pancreatic intraepithelial neoplasia were statistically significant (p<0.001). Conclusions: Overexpression of mucin 1, 4 and 5AC is related to the presence of pancreatic intraepithelial neoplasia. This suggests that overproduction of mucus is a phenomenon occurring early in the process of carcinogenesis in the pancreas and has its beginning in precancerous lesions of an early stage.
Źródło:
Progress in Health Sciences; 2018, 8(1); 63-73
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Horners syndrome during spindle cell lipoma of theneck–a case report
Autorzy:
Kaczmarczyk, Dariusz
Kubiak, Marcin
Komoń-Kotecka, Ewa
Bartoszewicz, Robert
Bruzgielewicz, Antoni
Powiązania:
https://bibliotekanauki.pl/articles/1401930.pdf
Data publikacji:
2014
Wydawca:
Index Copernicus International
Tematy:
Spindle cell lipoma
Immunohistochemistry
Horner's syndrome
Opis:
Horner's syndrome is most often caused by a tumour compressing the sympathetictrunk. Spindle cell lipoma (SCL) is a rare tumour, corresponding to just 1.5% of the benigntumours of soft tissues. Its most common localisation is subcutaneous tissue in theupper part of the body. This paper presents a rare case of Horner's syndrome caused bya SCL of the neck.A 42-year-old male patient was admitted to the ENT Ward of the Mazovian SpecialHospital in Siedlce because of a neck tumour on the left side. Laryngological examinationrevealed only a hard tumour with a limited mobility on the left side of the neck. Oph-thalmological and neurological consultations indicated Horner's syndrome. Fine-needleaspiration biopsy gave no clear diagnosis. The patient was qualified for surgery. Thetumour was radically excised and sent for histopathological examination. Thefinal his-topathological diagnosis was: SCL. Symptoms of the Horner's syndrome disappearedwithin 3 weeks after the surgery.The discussed case should be noted because of untypical SCL localisation within thecervical perivascular space, and also because of presence of symptoms of Horner's synd-rome caused by compression of the tumour on the sympathetic trunk that disappearedfollowing the surgical treatment.
Źródło:
Polski Przegląd Otorynolaryngologiczny; 2014, 3, 4; 222-225
2084-5308
2300-7338
Pojawia się w:
Polski Przegląd Otorynolaryngologiczny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Immunohistochemical study on the development of cholinergic and nitrergic nerve structures in the bovine esophageal groove
Autorzy:
Marszałek, M.
Serzysko, T.
Sienkiewicz, W.
Powiązania:
https://bibliotekanauki.pl/articles/16539106.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
esophageal groove
acetylcholine
nitric oxide
immunohistochemistry
development
Opis:
The proper functioning of the perinatal sucking reflex in calves is essential for the prevention of milk leakage into the rumen. The complex process behind its regulation is mediated at the gut level via multiple excitatory and inhibitory neurotransmitters, of which acetylcholine and nitric oxide are of fundamental importance. The aim of our study was to depict age-related alterations in the cholinergic and nitrergic innervation of the esophageal groove (EG) using immunohistochemistry and Real-Time PCR methods. We found out that the highest number of cholinergic nerve cells was present in the second trimester fetuses. From this developmental stage onward, their amount was gradually decreasing and reached the lowest value in 4-year-old cows. The same developmental pattern was observed for nitrergic nerve structures with the highest percentage of nitrergic neurons in the third trimester fetuses. Our observations prove that both neuronal populations are crucial for a proper closure of EG in calves. Therefore, their contribution to a general neuronal activity in the ENS diminishes with age as the high motility of a gastric groove is not necessarily required in older cattle.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 1; 165-174
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of follicle-stimulating hormone receptor (FSHR), protein kinase B-2 (AKT2) and adapter protein with PH domain, PTB domain, and leucine zipper (APPL1) in pig ovaries
Autorzy:
Ning Zhou
Ning Wang
Xiang Qin
Qian Liu
Juhua Wang
Hui Dong
Jie Zhou
Fugui Fang
Powiązania:
https://bibliotekanauki.pl/articles/2087861.pdf
Data publikacji:
2017
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
pigs
immunohistochemistry
FSHR
AKT2
APPL1
Źródło:
Polish Journal of Veterinary Sciences; 2017, 4; 661-667
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
High expression of CD133 – stem cell marker for prediction of clinically agressive type of colorectal cancer
Autorzy:
Kostovski, Ognen
Antovic, Svetozar
Trajkovski, Gjorgji
Kostovska, Irena
Jovanovic, Rubens
Jankulovski, Nikola
Powiązania:
https://bibliotekanauki.pl/articles/1391698.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
CD133
colorectal cancer
immunohistochemistry
stem cells
Opis:
Background: Colorectal cancer (CRC) is one of the most common malignancies in the world. The cancer stem cell (CSC) markers are associated with aggressive cancer types and poor prognosis. The objective of the study was to evaluate the CD133 expression and to correlate it with clinicopathological features in patients with CRC. Material and Methods: Our study included ninety patients with CRC who underwent curative surgical resection from 2012 to 2017 at the University Clinic for Digestive Surgery, Skopje, North Macedonia. Tumor samples were first analyzed with standard histopathological methods and then the CD133 expression was investigated immunohistochemically. The level of expression of CD133 was classified semiquantitatively. Low positivity was defined as positive immunoreactivity in <50% of tumor glands, and high positivity was defined as positive immunoreactivity in ≥50% of tumor glands. Furthermore, clinicopathological features of patients were retrospectively reviewed. Results: High expression of CD133 was found in 47.8% of patients’ CRC samples. In 69.6% of patients with metastatic lesions in visceral organs we found high expression of CD133. We found statistically significant differences in the expression of CD133 between patients with and without visceral metastatic lesions (P = 0.0153), between patients with a different T category (P = 0.0119), N status (P = 0.0066) and grade (G) (P = 0.0115). Our results showed that the stage of disease has the greatest impact on expression of CD133 (P < 0.00001). Conclusion: High expression of CD133 is a useful marker for prediction of the clinically aggressive type of CRC and can be routinely implemented in standard pathohistological diagnostics.
Źródło:
Polish Journal of Surgery; 2020, 92, 3; 9-14
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-10 z 41

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