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Wyszukujesz frazę "imidazole" wg kryterium: Temat


Wyświetlanie 1-15 z 15
Tytuł:
Novel Synthesis, spectral, characterization of 4,5-diphenyl-1-((tetrahydrofuran-2-yl)methyl)-2-(3,4,5-trichlorophenyl)-1H-imidazole and its applications of molecular docking, anticancer activity
Autorzy:
Dhineshkumar, E.
doss, M. Arockia
Uma, D.
Powiązania:
https://bibliotekanauki.pl/articles/1031882.pdf
Data publikacji:
2020
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
HepG2
Imidazole
cytotoxicity
molecular docking
Opis:
In the present study of 4,5-diphenyl-1-((tetrahydrofuran-2-yl)methyl)-2-(3,4,5-trichlorophenyl)-1H-imidazole 1 was synthesized. The synthesized imidazole compound 1 has been characterized by FT-IR, 1H, 13C NMR and ESI-Mass spectral studies. Molecular docking is also performed in order to explain the over-expression of estrogen receptor in 70% of liver cancer. The imidazole scaffold is a privileged scaffold for exploration of anticancer agents. The objective of the present study is to evaluate the anticancer activity of imidazole 1 in human liver cancer cell lines HepG2.
Źródło:
World News of Natural Sciences; 2020, 30, 2; 203-212
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Acid-Promoted Synthesis of Imidazolyl-Pyrazole Derivatives via a Multicomponent Reaction Using Ultra Sound Irradiation
Autorzy:
Baria, B.
Viradiya, D.
Kotadiya, V.
Kakadiya, R.
Shah, A.
Powiązania:
https://bibliotekanauki.pl/articles/412490.pdf
Data publikacji:
2014
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
Imidazole
ultrasound irradiation
Imidazolyl-Pyrazole
Benzil
Opis:
Some new imidazolyl pyrazole derivatives have been synthesized using benzil, ammonium acetate, and heterocyclic aldehyde in ethanol and acetic acid under ultra sound irradiation. The obtained products using this approach are having high purity and good in yield. By conducting the reactions in ethanol, the solid products were precipitated out and could be isolated simply by filtration. The synthesized compounds were characterized by various analytical techniques such as 1H and 13C NMR and further supported by mass spectroscopy.
Źródło:
International Letters of Chemistry, Physics and Astronomy; 2014, 11, 3; 277-283
2299-3843
Pojawia się w:
International Letters of Chemistry, Physics and Astronomy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Flotation separation of quartz from phosphorite using an imidazole ionic liquid collector and its adsorption mechanism
Autorzy:
Zhao, Yuanyuan
Xu, Wei
Mei, Guangjun
Yu, Mingming
Yang, Siyuan
He, Zhan
Powiązania:
https://bibliotekanauki.pl/articles/2146857.pdf
Data publikacji:
2022
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
reverse flotation
imidazole ionic liquid
desilication
phosphorite
quartz
Opis:
In this study, an imidazole ionic liquid (dodecyl-tri-methylimidazolium chloride) was employed as a collector to separate quartz from phosphorite. The micro-flotation experiments of a single mineral found that it had selective collecting ability for quartz than phosphorite. Mixed mineral flotation experiments confirmed that efficient separation results could be obtained using the imidazole ionic liquid as the collector. A concentrate with a 31.44% grade of phosphorite could be obtained with a 0.285 kg/Mg collector dosage at neutral pH, which was much better than the traditional collector dodecylamine. The adsorption mechanism of the imidazole ionic liquid on the surface of phosphorite and quartz was investigated by contact angle and zeta potential measurements, Fourier transform infrared and X-ray photoelectron spectroscopy analyses. These results showed that the adsorption of imidazole ionic liquid at the quartz surface was stronger than that of phosphorite, and the collector adsorbability difference between quartz and phosphorite resulted in the efficient flotation separation. Consequently, the dodecyl-tri-methylimidazolium chloride salt is an effective collector for reverse flotation of quartz from phosphorite.
Źródło:
Physicochemical Problems of Mineral Processing; 2022, 58, 1; 159--168
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Some High Nitrogen Derivatives of Nitrotetrazolylimidazole as New High Performance Energetic Compounds
Autorzy:
Zohari, N.
Keshavarz, M. H.
Seyedsadjadi, S. A.
Powiązania:
https://bibliotekanauki.pl/articles/358162.pdf
Data publikacji:
2014
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Organicznego
Tematy:
nitrotetrazolyl-imidazole
high energy material
performance
safety
thermochemical property
Opis:
This work introduces important properties of some new derivatives of nitrotetrazolyl-imidazole as high nitrogen energetic compounds, which are evaluated and discussed using some reliable models. The predicted properties are also compared with 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX). It is shown that some of these compounds can be seen as interesting organic explosives with relatively high performance and low sensitivity, which could be used for important industrial applications. Since some of the new compounds have a relatively good oxygen balance, the calculated specific impulses confirm that these compounds can be considered as suitable oxidizers in solid propellants.
Źródło:
Central European Journal of Energetic Materials; 2014, 11, 3; 349-362
1733-7178
Pojawia się w:
Central European Journal of Energetic Materials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Antiplatelet action of losartan involves TXA2 receptor antagonism but not TXA2 synthase inhibition
Autorzy:
Chlopicki, S.
Koda, M.
Chabielska, E.
Buczko, W.
Gryglewski, R.J.
Powiązania:
https://bibliotekanauki.pl/articles/70180.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
thromboxane A2
synthase inhibition
imidazole
antiplatelet action
losartan
platelet
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 4,1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Protochlorophyllide photoreduction in angiosperms: focus on protochlorophyllide – surroundings interaction in model system
Autorzy:
Mysliwa-Kurdziel, B.
Gabruk, M.
Kruk, J.
Strzalka, K.
Powiązania:
https://bibliotekanauki.pl/articles/79978.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
protochlorophyllide
angiosperm
chlorophyll
photosynthetic reaction
fluorescence intensity
imidazole
model system
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of polymer inclusion membranes doped with 1-hexyl-4-methylimidazole for pertraction of zinc(II) and other transition metal ions
Autorzy:
Ulewicz, M.
Radzyminska-Lenarcik, E.
Powiązania:
https://bibliotekanauki.pl/articles/110567.pdf
Data publikacji:
2015
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
polymer inclusion membrane
PIM
metal ions separation
zinc(II)
transition metal ions
imidazole derivatives
Opis:
Transport of Zn(II) from unary aqueous chloride solutions and from solutions which contain mixtures of Cd(II), Co(II) and Ni(II) ions in source phases (cMe = 0.001 mol/dm3, pH = 6.0) across polymer inclusion membranes (PIMs) doped with 1-hexyl-4-methylimidazole as ion carrier was studied. The use of 1-hexyl-4-methylimidazole enables the separation of 98.5% Zn(II) from a unary solution and 96.9% from a quaternary solution of Zn(II)-Cd(II)-Co(II)-Ni(II) after running the process for 24 hours. Using that ion carrier, the metals are transported in the following order: Zn(II) > Cd(II) > Ni(II) > Co(II), and the selectivity coefficients of Zn(II)/Cd(II), Zn(II)/Ni(II), and Zn(II)/Co(II) are 12.9, 23.4 and 40.8, respectively. Findings of atomic force microscopy (AFM) examinations as well as thermograms of a polymer inclusion membrane containing 1-hexyl-4-methylimidazole are also presented. A membrane with 1.0 mol/dm3 of carrier has a porosity of 15.8%, and roughness of 6.6 nm. The membranes remain thermally stable at temperatures up to 200oC. The findings were compared with earlier-reported results for 1-hexylimidazole.
Źródło:
Physicochemical Problems of Mineral Processing; 2015, 51, 2; 447-460
1643-1049
2084-4735
Pojawia się w:
Physicochemical Problems of Mineral Processing
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spectroscopic study of a bis(imidazole) (octaethylporphyrinato)iron(III) complex
Autorzy:
Rutkowska, I.
Dziliński, K.
Kaczmarzyk, T.
Stanek, J.
Powiązania:
https://bibliotekanauki.pl/articles/146898.pdf
Data publikacji:
2013
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
electron paramagnetic resonance (EPR) spectroscopy
Mössbauer spectroscopy
low-spin iron porphyrin
imidazole axial ligands
Opis:
Low-spin ferric octaethylporphyrinatoiron complex with two imidazole axial ligands [Fe(III)(OEP)(Im)2]+ has been investigated by electron paramagnetic resonance (EPR) and Mössbauer spectroscopies. It was found that the ground spin state corresponds to the electron configuration (dxy)2 (dxz, dyz)3 and planes of the imidazole axial ligands have a parallel mutual orientation. Ethyl groups bonded to pyrrole rings, as peripheral substituents, effect on the ground electron spin state of the complex studied and the relative orientation of the the imidazole axial ligands in a similar way like the phenyl substituents bonded to meso-carbon atoms of the porphyrin macrocycle. The temperature dependence of the Mössbauer spectra is discussed in terms of magnetic relaxation processes.
Źródło:
Nukleonika; 2013, 58, 3; 419-423
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Search for the possibility of utilizing the differences in complex-forming capacities of alkylimidazoles for selective extraction of some metal ions from aqueous solutions
Autorzy:
Radzymińska-Lenarcik, E.
Powiązania:
https://bibliotekanauki.pl/articles/778263.pdf
Data publikacji:
2008
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
ekstrakcja selektywna
alkiloimidazol
jony metali przejściowych
selective extraction
alkyl imidazole derivatives
transition metals ions
Opis:
Alkyl substituents in position 1 of the imidazole ring distinctly affect the hydrophobic properties of the molecule and strengthen its basicity. Hence, 1-alkylimidazoles have been used as extractants of a number of metal ions. Again, a methyl substituent in position 2 of the imidazole ring raises by an order of magnitude the basicity. At the same time, the substituent impedes the formation of the 2-alkylimidazole complexes with metal ions due to the steric effect. By the substitution of alkyl groups in position 1 or 2 of the imidazole ring it is possible to program the extraction properties of extractants and to control the selectivity of extraction.
Źródło:
Polish Journal of Chemical Technology; 2008, 10, 1; 73-78
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Greener, facile and ultrasound assisted synthesis of 1,2,3-triazole via CuAAC of 2-(azidomethyl)-1H-benzo[d]imidazole and alkynes and their evaluation of antimicrobial activity
Autorzy:
Kapupara, Vimalkumar H.
Kalavadiya, Prakash L.
Gojiya, Dinesh G.
Parmar, Nilesh D.
Joshi, Hitendra S.
Powiązania:
https://bibliotekanauki.pl/articles/1075696.pdf
Data publikacji:
2019
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
1
1H-benzo[d]imidazole azide
2
3-triazol-1-yl)methyl)-1H-benzo[d]imidazole
3-triazole via CuAAC
4-disubstituted 1H-1
alkynes
antimicrobial
copper(I) catalyst
Opis:
An expeditious room temperature protocol for the synthesis of 1,4-disubstituted 1H-1,2,3-triazol-1-yl)methyl)-1H-benzo[d]imidazole from [3+2] cyclization by using 1H-benzo[d]imidazole azide and various substituted terminal alkynes and copper(I) as a catalyst. This synthetic approach has been various prominent features such as fewer reaction steps, Good Yield, simple reaction condition and no any further purification required. Characterizations of all the synthesized compounds were done by various spectroscopic techniques like FT-IR, NMR and Mass spectrometry. All the synthesized targeted compounds were screened and evaluated for their antimicrobial activities.
Źródło:
World Scientific News; 2019, 119; 139-167
2392-2192
Pojawia się w:
World Scientific News
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Epoxy adhesive formulations using latent imidazole metal cation complexes
Autorzy:
Pilawka, R.
Maka, H.
Powiązania:
https://bibliotekanauki.pl/articles/779382.pdf
Data publikacji:
2011
Wydawca:
Zachodniopomorski Uniwersytet Technologiczny w Szczecinie. Wydawnictwo Uczelniane ZUT w Szczecinie
Tematy:
kleje epoksydowe
utwardzacze
kompleksy imidazoli
wytrzymałość na ścinanie
epoxy adhesives
latent curing agent
imidazole complexes
pot life
shear strength
Opis:
Complexes of 2-methylimidazole with cations from several metal sulfates were prepared and investigated as curing agents for epoxy resins. The reactivity of one-part formulations of these complexes with a bisphenol A type epoxy resin was determined by the differential scanning calorimetry and the pot life observed by viscosity measurements. Tensile lap shear tests at room temperature and at 120°C were used to evaluate the adhesive strength of the formulations directly after preparation as well as after one and three months of storage at room temperature. The DSC measurements showed much lower reactivity (7 - 32%) and higher reaction temperatures of the complex formulations in comparison to the mixtures with pure 2-methylimidazole. The viscosity of most formulations remained almost unchanged over the observed period of three months. The adhesive strength of the freshly prepared complex formulations is comparable to a formulation with pure 2-methylimidazole and decreases over time, depending on the type of metal cation and the cation-to-imidazole molar ratio. The obtained results indicate that complexes of 2-methylimidazole with cations are suitable as latent curing agents for epoxy resins.
Źródło:
Polish Journal of Chemical Technology; 2011, 13, 1; 63-66
1509-8117
1899-4741
Pojawia się w:
Polish Journal of Chemical Technology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Determination of in vitro metabolism of new non-imidazole histamine H3 receptor antagonist 1-[3-(4-tert-butylphenoxy)propyl]piperidine
Autorzy:
Kryczyk-Poprawa, Agata
Szafarz, Małgorzata
Palak, Aneta Palak
Łażewska, Dorota
Kuś, Kamil
Opoka, Włodzimierz
Szymura-Oleksiak, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/895240.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
1-[3-(4-tert-butylphenoxy)propyl]piperidin
well-stirred model
parallel tube model
non-imidazole histamine H3 receptor antagonist
Opis:
Early understanding of the pharmacokinetics of drug candidates is essential during the evaluation of drug development process. DL76 1-[3-(4-tert-butylphenoxy)propyl]piperidine is a novel promising non-imidazole H3 receptor antagonist. Presented study was undertaken to compare with each other the predicted hepatic clearance values of DL76 calculated, using two most common mathematical models “well-stirred” and “parallel tube”, based on the data obtained in in vitro experiments. The metabolic intrinsic clearance of DL76 equaled to 0.4848 mL/min/mg protein was scaled up and the values of hepatic clearance estimated from "well-stirred" and "parallel tube" models were 55.47 mL/min/kg and 58.80 mL/min/kg, respectively. They were further compared with pharmacokinetic parameters calculated based on the concentration-time profile obtained following intravenous administration of DL76 to rats at the dose of 6 mg/kg. The estimated systemic serum clearance value of 144.5 mL/h/kg and blood clearance value of 81.17 mL/min/kg indicate the potential extrahepatic metabolism of the investigated compound. This study demonstrates the utility of rat liver microsomes for the prediction of DL76 hepatic clearance.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 877-884
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Otrzymywanie i badanie właściwości 4,4',5,5'-tetranitro-2,2'-bi-1H-imidazolu (TNBI)
Synthesis and properties of 4,4',5,5'-tetranitro-2,2'-bi-1H-imidazole
Autorzy:
Szala, M.
Lewczuk, R.
Powiązania:
https://bibliotekanauki.pl/articles/210793.pdf
Data publikacji:
2013
Wydawca:
Wojskowa Akademia Techniczna im. Jarosława Dąbrowskiego
Tematy:
tetranitrobiimidazol
nitrowanie
małowrażliwe materiały wybuchowe
4,4',5,5'-tetranitro-2,2'-bi-1H-imidazole
nitration
low sensitivity explosives
Opis:
Wykonano przegląd metod nitrowania 2,2'-biimidazolu od jego odkrycia do roku 2012. Zaproponowano dwie nowe ścieżki nitrowania 2,2'-biimidazolu do 4,4',5,5'-tetranitro-2,2'-bi-1H-imidazolu (TNBI). Strukturę produktu pośredniego i TNBI określono na podstawie wyników badań spektroskopowych (¹H, ¹³C NMR, IR). Stwierdzono, że TNBI tworzy stabilny hydrat, który ulega odwodnieniu w temperaturze ok. 80°C. Na podstawie wyników badania DTA /TG określono, że TNBI zachowuje stabilność do temperatury 277°C po czym bez topnienia ulega egzotermicznemu rozkładowi. Zmierzona prędkość detonacji TNBI wynosi 7950 m/s przy gęstości 1,72 g/cm³.
The known synthesis methods of 4,4',5,5'-tetranitro-2,2'-bi-1H-imidazole (TNBI) are reviewed. Two novel nitration methods of 2,2'-biimidazole to TNBI were presented. Solid products of reactions were analyzed using ¹H, ¹³C NMR and IR spectroscopy. Thermal stability has been studied by DTA. Friction sensitivity of main product was examined. Heat of combustion was measured and standard enthalpy of formation was calculated. Detonation velocity of TNBI for the density of 1.72 g/cm³ was measured.
Źródło:
Biuletyn Wojskowej Akademii Technicznej; 2013, 62, 1; 34-43
1234-5865
Pojawia się w:
Biuletyn Wojskowej Akademii Technicznej
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Synthesis and characterization of novel pyrimidine derivatives of N-pentyl-2,7-diphenyl-3,8a-dihydroimidazo[1,2-a]pyrimidin-3-amine via 4-phenylpyrimidin-2-amine
Autorzy:
Ramade, Kadachha Raju
Rojivadiya, Atul J.
Naliapara, Yogesh T.
Babariya, Jayesh S.
Powiązania:
https://bibliotekanauki.pl/articles/1839572.pdf
Data publikacji:
2021
Wydawca:
Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:
imidazole
pyrimidine
N-pentyl-2.7-diphenyl-3.8a-dihydroimidazo[1.2-a]pyrimidin-3-amine
4-phenylpyrimidin-2-amine
triflouro acetic acid
benzyldehyde
Opis:
The target compound N-pentyl-2,7-diphenyl-3,8a-dihydroimidazo[1,2-a]pyrimidin-3-amine have been synthesized by4-phenylpyrimidin-2-amine with Triflouro acetic acid and benzyldehyde. The obtained products were characterized by 1H NMR, Mass and IR Spectra. Purity of all the compounds has been checked on thin layer chromatographic plate and NMR analysis technique.
Źródło:
World News of Natural Sciences; 2021, 37; 92-101
2543-5426
Pojawia się w:
World News of Natural Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Receptor histaminowy H3 – budowa, funkcje, aktywne ligandy
Histamine H3 receptor – structure, functions, active ligands
Autorzy:
Masłowska-Lipowicz, Iwona
Powiązania:
https://bibliotekanauki.pl/articles/412777.pdf
Data publikacji:
2019
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Przemysłu Skórzanego
Tematy:
histamina
receptor histaminowy H3
agonista receptora H3
odwrotny agonista receptora H3
imidazol
histamine
H3 receptor
agonists histamine H3
inverse agonists histamine H3 receptor
imidazole
Opis:
Receptor histaminowy H3 został odkryty w 1983 roku przez Schwartza [1]. Od tego czasu w wielu ośrodkach naukowych trwają poszukiwania aktywnych ligandów H3. Literatura opisuje liczne związki, które są aktywne (antagoniści/odwrotni agoniści) wobec H3, jednak w chwili obecnej niewiele leków znajduje się w rutynowej praktyce klinicznej (betahistyna, pitolisant). Antagoniści/odwrotni agoniści H3 stanowią atrakcyjny cel w poszukiwaniu nowych leków. Dane przedkliniczne i kliniczne wskazują na ich potencjalną przydatność w leczeniu różnych chorób ośrodkowego układu nerwowego (OUN) takich, jak: narkolepsja, katalepsja, ADHD, choroba Alzheimera, a ponadto zaburzeń metabolicznych czy alergii.
The histamine H3 receptor was discovered in 1983 by Schwartz and coauthors [1]. In many scientific centers, the search for active H3ligands is continued to this day. The literature describes a many compounds that are active (antagonists/inverse antagonists) against H3, however at present, only few drugs are found in routine clinical practice (betahistine, pitolisant). H3 antagonists/inverse agonists are an attractive target in the search for new drugs. Preclinical and clinical data indicate their potential usefulness in the treatment of various central nervous system (CNS) diseases, such as narcolepsy, catalepsy, ADHD, Alzheimer’s disease, as well as metabolic disorders or allergies.
Źródło:
Technologia i Jakość Wyrobów; 2019, 64; 14-23
2299-7989
Pojawia się w:
Technologia i Jakość Wyrobów
Dostawca treści:
Biblioteka Nauki
Artykuł
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