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Wyszukujesz frazę "hydrophilic globules" wg kryterium: Temat

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    Wyświetlanie 1-3 z 3
    Tytuł:
    Evaluation of hydrophilic globules with sodium alginate containing a lactic acid– chitosan complex
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/2131517.pdf
    Data publikacji:
    2021
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic globules
    lactic acid-chitosan complex
    physiological environment of vagina
    vaginal mucosa
    vaginal infections
    Opis:
    An important issue in the treatment of vaginitis is the amount of time the drug remains on the vaginal mucosa. If the contact time is too short, the drug cannot work effectively to ensure the correct pH in the vaginal environment. This study evaluated formulations of globules containing sodium alginate, lactic acid and chitosan with different pH and rheological properties. The experimental studies revealed that it is possible to produce a preparation with optimal pharmaceutical and application properties. The use of an appropriate ratio of lactic acid to chitosan in the complex and the appropriate concentration of sodium alginate produces a preparation with excellent properties to coat the surface of the vaginal mucosa.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2021, 26; 170-177
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Research of hydrophilic globules containing a lactic acid-chitosan complex
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1034096.pdf
    Data publikacji:
    2020
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic globules
    lactic acid-chitosan complex
    physiological environment of vagina
    vaginal infections
    vaginal mucosa
    Opis:
    Gynecological scientific journals report that traditional therapeutic regimens used to treat vaginal inflammation recommended by global treatment centers and health organizations are not producing satisfactory results. Insufficient duration of the drug’s contact with vaginal mucosa does not provide adequate pH conditioning the physiological biocenosis of the organ. The conducted research and obtained positive results encourage further research possibilities in the field of optimization of pharmaceutical properties of the examined gynecological preparations. Assuming the above assumptions tested impact of polyvinylpyrrolidone K-15, polyvinylpyrrolidone K-30 and polyvinylpyrrolidone K-90 in the properties of the globules. The study was prepared formulations with different pH and rheological properties. The device simulating the conditions in the vagina, studied the adhesion and movement of the gel on the mucosa of the organ. Globules after application of the apparatus simulates the natural conditions in the gel passes and cover the surface. A wide range of pH of the gels allows the selection of the optimum formulation.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 143-150
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The properties of intravaginal globules containing a lactic acid-chitosan complex
    Autorzy:
    Małolepsza-Jarmołowska, Katarzyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1034204.pdf
    Data publikacji:
    2019
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    anti-inflammatory drugs
    hydrophilic globules
    lactic acid-chitosan complex
    physiological environment of vagina
    vaginal infections.
    vaginal mucosa
    Opis:
    Continuing the implementation of research on the problem of treatment of vaginal pH disorders, intravaginal globules were examined as vaginal drug form which carries the lactic acid complexes with chitosan. The intravaginal application of globules that transform into gel under natural conditions is aimed at achieving the physiological pH of the vaginal environment. Formulations were prepared with varying pH and rheological properties. The test showed the work of adhesion of gels. All gels with ratios of 1:1 and 2:1 of lactic acid to chitosan showed a pH in the physiological range at 37°C. Additional hydroxypropylmethylcellulose and excipients allows various formulations with a wide range of pH to be obtained. Rheological investigation revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and hydroxypropylmethylcellulose in comparison to the gels without hydroxypropylmethylcellulose. The study of the work of adhesion showed the effect of hydroxypropylmethylcellulose and their concentration on the value of the work of adhesion.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2019, 24; 127-134
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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