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Tytuł:
Expression of vascular endothelial growth factor and microvessel density in oral squamous cell carcinoma and its correlation with various clinico-pathological parameters
Autorzy:
Panigrahi, Ranjita
Jha, Narendra Kumar
Hota, Subhransu Kumar
Powiązania:
https://bibliotekanauki.pl/articles/38695726.pdf
Data publikacji:
2024-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
microvessel density
oral squamous cell carcinoma
vascular endothelial growth factor
Opis:
Introduction and aim. Angiogenesis, which is accomplished by capillary sprouting, is the process by which new vessels are created from pre-existing ones. In tumor, once their initial blood supply is depleted, a tumour is unable to grow without additional blood flow. Additionally, a tumor’s microvasculature, or microvessel density (MVD), increases along with its capacity to produce angiogenesis. We aimed to observe the relationship between the expression of vascular endothelial growth factor (VEGF) and MVD (using CD34) in oral squamous cell carcinoma (OSCC). Material and methods. The expression of VEGF and CD34 antibodies was analysed using immunohistochemistry method on 50 cases of histopathologically proved OSCC. The expression was correlated with clinicopathological parameters. Results. A significant correlation was observed between VEGF expression and gender, LVSI. No correlation between any other factors and the difference in VEGF expression was statistically significant. Similarly, the MVD expression was not found to be statistically significant in any of the pathological parameters. Conclusion. VEGF positivity as well as MVD were found to be independent of the tumor pathology. Tumor MVD was found to be independent of the expression of VEGF. Further studies in a larger study group may establish a significant association so that antiangiogenic targeted therapy may be initiated.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 82-87
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
W jaki sposób słabiej rozwinięta gospodarka może dogonić liderów? Znaczenie zagregowanej produktywności
How a less developed economy can catch up with the leaders? The role of aggregate productivity
Autorzy:
Orłowski, Witold
Powiązania:
https://bibliotekanauki.pl/articles/31343829.pdf
Data publikacji:
2024
Wydawca:
Kancelaria Sejmu. Biuro Ekspertyz i Oceny Skutków Regulacji
Tematy:
total factor productivity
economic growth
growth accounting
technological progress
industrial policy
Productivity Strategy 2030
Opis:
There exist many examples of countries that have seriously reduced, over the past 150 years, the development gap vis-à-vis economic leaders. The decisive factor was the rapid increase of the total factor productivity (TFP), possible due to the technological progress. In the article, the author verified 6 important hypotheses underlying the Productivity Strategy 2030 published by the Polish government, on the basis of the experience of 96 countries around the world over the last 60 years. Most of these hypotheses were positively verified. However, when implementing the Strategy, one should remember that the increase in the aggregate productivity observed throughout the economy is only the combined effect of the increase in productivity occurring at the enterprise level. Therefore, the pursuit of more developed countries requires, first of all, the creation of appropriate conditions for the development of enterprises.
Źródło:
Studia BAS; 2024, 1(77); 7-28
2080-2404
2082-0658
Pojawia się w:
Studia BAS
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Sustainable growth rate, corporate value of US firms within capital and labor market distortions: The moderating effect of institutional quality
Autorzy:
Bagh, Tanveer
Naseer, Mirza Muhammad
Khan, Muhammad Asif
Pypłacz, Paula
Oláh, Judit
Powiązania:
https://bibliotekanauki.pl/articles/39827486.pdf
Data publikacji:
2023
Wydawca:
Instytut Badań Gospodarczych
Tematy:
factor market distortion
capital and labor market distortions
corporate value
institutional quality
corporate sustainable growth rate
micro-level analysis
Opis:
Research background: Understanding how distortions in capital and labor markets affect corporate value and sustainable growth is crucial in today's economy. These distortions can disrupt resource allocation and economic sustainability. Additionally, the role of institutional quality in shaping these dynamics requires thorough exploration. Purpose of the article: We quantify the effect of capital and labor market distortions on corporate value and sustainable growth rate (SGR) and how this association is moderated by institutional quality. Methods: Stemming from the sample criteria, we calibrated a final sample of 1971 United States-listed manufacturing firms for 2012–2022. This research offers insights into market inefficiencies and institutional effects. Progressing towards objectives, we use advanced techniques like feasible generalized least squares and generalized methods of moments. These methods help us rigorously analyze complex relationships among study variables. Findings & value added: Three key findings emerge: first, capital and labor market distortions have a negative and significant influence on corporate value and sustainable growth. Our primary finding implies that increasing distortions significantly reduce sustainable growth's value and potential. Second, we find institutional quality has a positive significant effect on corporate value and sustainable growth. Third, institutional quality positively moderates the association between capital and labor market distortions, corporate value, and sustainable growth. Findings suggest that institutional quality, as a potential mechanism, improves the efficiency of resource allocation and optimizes the sustainable economic system to lessen the negative effect of factor market distortions on corporate value and SGR. Besides, we conduct robustness checks to validate our findings. Finally, we offer policymakers and stakeholders actionable insights.
Źródło:
Oeconomia Copernicana; 2023, 14, 4; 1211-1255
2083-1277
Pojawia się w:
Oeconomia Copernicana
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Is the division of Western and Eastern Poland still valid? The evolution of regional convergence in Poland
Autorzy:
Misiak, Tomasz
Powiązania:
https://bibliotekanauki.pl/articles/2058085.pdf
Data publikacji:
2022-07-11
Wydawca:
Uniwersytet Ekonomiczny w Poznaniu
Tematy:
club convergence
catch-up eefct
log(t) convergence test
economic growth
time-varying factor model
Opis:
The primary aim of the paper is the empirical vericfiation of the hypothesis on the convergence of real GDP per capita of the regions (NUTS-2) in Poland and the catch-up eefct of Eastern towards Western Poland. The empirical study is based on a relatively new analytical approach of Phillips and Sul convergence tests which consider signicfiant diefrences in technological advancement between regions. The results show that the convergence hypothesis was rejected in the group of all regions of Poland and the group of Western Poland regions. Convergence was conrfimed in the group of Eastern Poland regions. The strict catch-up eefct of the Eastern towards the Western Poland regions was not observed. Nevertheless, thirteen of seventeen regions of Poland were characterised by convergence but within distinct convergence clubs. The identicfiation of convergence clubs, however, was not determined by a sharp EastWest Poland dividing line.
Źródło:
Economics and Business Review; 2022, 8, 2; 145-169
2392-1641
Pojawia się w:
Economics and Business Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Preliminary results of blood growth differentiation factor-9 (GDF-9) measurement in cats: future aspects of GDF-9 on stage of the cycle and spaying history
Autorzy:
Evkuran Dal, G.
Baykal, A.
Toydemir Karabulut, T.S.F.
Dokuzeylul Gungor, N.
Turna, O.
Powiązania:
https://bibliotekanauki.pl/articles/16539104.pdf
Data publikacji:
2022
Wydawca:
Polska Akademia Nauk. Czasopisma i Monografie PAN
Tematy:
cats
growth differentiation factor 9
ovarian cycle
ovary
Opis:
Growth differentiation factor-9 (GDF-9), an oocyte-derived member of the TGF-β superfamily, plays an essential role in regulation of follicular development. This study aimed to determine the cyclic changes in serum GDF-9 concentration, compare its levels before and after ovariohysterectomy (OHE), and investigate its potential as a tool in ovarian remnant syndrome (ORS) diagnosis in cats. GDF-9 measurements were performed on 50 cats referred for routine OHE. The stage of the estrous cycle was determined by vaginal cytology and measurement of serum estradiol and progesterone levels was carried out to detect the cyclic changes in circulating GDF-9. One week after OHE, serum samples were collected again from 30 cats to reveal differences in GDF-9 levels. GDF-9 levels in the follicular phase were significantly higher than those in the interestrus (p<0.05). The postoperative analysis could be performed. GDF-9 levels slightly decreased one week after OHE (p=0.053). In conclusion, blood GDF-9 levels change during the estrous cycle, and may decrease with age in cats. However, further studies are needed to reveal the efficiency of GDF-9 in ORS diagnosis.
Źródło:
Polish Journal of Veterinary Sciences; 2022, 25, 1; 149-154
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Serum levels of VEGF-A, sVEGFR-2 and galectin-3 do not correlate with clinical stage, tumor size, or effectiveness of perioperative chemotherapy in patients with non-metastatic breast cancer
Stężenie VEGF-A, sVEGFR-2 i galektyny-3 w surowicy pacjentek z rakiem piersi nie koreluje ze stopniem zaawansowania klinicznego, wielkością guza ani skutecznością chemioterapii okołooperacyjnej
Autorzy:
Grochoła-Małecka, Iga
Czajka-Francuz, Paulina
Owczarek, Aleksander J.
Wojnar, Jerzy
Handzlik, Gabriela
Francuz, Tomasz
Chudek, Jerzy
Powiązania:
https://bibliotekanauki.pl/articles/2122930.pdf
Data publikacji:
2022-09-29
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
breast cancer
angiogenesis
galectin-3
vascular endothelial growth factor
chemotherapy
rak piersi
angiogeneza
galektyna-3
czynnik wzrostu śródbłonka naczyń
chemioterapia
Opis:
INTRODUCTION: Tumor angiogenesis is regulated by numerous cytokines and growth factors, with vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor 2 (sVEGFR-2), and galectin-3, playing a significant role in the process. There are conflicting data concerning changes in serum VEGF, sVEGFR-2 and galectin-3 levels in breast cancer (BC) patients during the course of the disease and chemotherapy (CTH). This study aimed to assess the serum levels of VEGF-A, sVEGFR-2, and galectin-3 in women starting adjuvant and neoadjuvant therapy for BC, and their changes during the treatment. MATERIAL AND METHODS: This single-center study enrolled 98 women with non-metastatic BC, including 56 who started adjuvant therapy and 42 preoperative (neoadjuvant/induction) CTH. The serum levels of VEGF-A, sVEGFR-2, and galectin-3 were assessed at the beginning of CTH and after 2 subsequent months. RESULTS: There were no significant differences in the serum levels of VEGF-A, sVEGFR-2, and galectin-3 between patients starting adjuvant and preoperative therapy. In addition, there was no correlation between the serum levels and the clinical stage of BC. During CTH, a significant increase in VEGF-A, sVEGFR-2, and galectin-3 was noted, however, without a predictive significance for obtaining complete pathological response (pCR) both for the initial levels and changes in the serum levels. CONCLUSIONS: The serum levels of VEGF-A, sVEGFR-2, and galectin-3 do not correlate with the clinical stage or tumor size in patients with non-metastatic BC. The baseline levels of VEGF-A, sVEGFR-2 and galectin-3, and the observed increase in the serum levels of VEGF-A and sVEGFR-2 during CTH do not predict its efficacy.
WSTĘP: Angiogeneza nowotworowa jest procesem regulowanym przez wiele cytokin i czynników wzrostu, spośród których znaczącą rolę odgrywają czynnik wzrostu śródbłonka naczyń (vascular endothelial growth factor – VEGF), drugi rozpuszczalny receptor dla śródbłonkowego czynnika wzrostu (soluble vascular endothelial growth factor recep-tor 2 – sVEGFR-2) i galektyna-3. Dane literaturowe dotyczące oceny zmian stężenia VEGF, sVEGFR-2 oraz galekty-ny-3 w trakcie chemioterapii (chemotherapy – CTH) raka piersi (breast cancer – BC) są niejednoznaczne. Celem niniej-szej pracy była analiza stężenia VEGF-A, sVEGFR-2 oraz galektyny-3 w surowicy pacjentek z rakiem piersi, rozpoczynających adjuwantową i neoadjuwantową chemioterapię oraz ocena zmian stężenia tych cytokin w trakcie leczenia. MATERIAŁ I METODY: Jednoośrodkowe badanie objęło 98 pacjentek z miejscowo zaawansowanym rakiem piersi, w tym 56 poddanych adjuwantowej i 42 neoadjuwantowej terapii. Stężenie VEGF-A, sVEGFR-2 i galektyny-3 w surowicy krwi oceniono na początku leczenia oraz po 2 miesiącach terapii. WYNIKI: Nie stwierdzono istotnych różnic pomiędzy stężeniami VEGF-A, sVEGFR-2 oraz galektyny-3 w surowicy pacjentek poddanych adjuwantowej i neoadjuwantowej chemioterapii. Nie wykazano również zależności między stężeniem tych cytokin w surowicy a stopniem zaawansowania klinicznego raka piersi. W trakcie przedoperacyjnej chemio-terapii odnotowano znaczące zwiększenie stężenia VEGF-A, sVEGFR-2 i galektyny-3, jednakże zarówno wyjściowe stężenia cytokin, jak i zmiany w czasie nie miały znaczenia predykcyjnego dla uzyskania całkowitej odpowiedzi pato-ogicznej. WNIOSKI: Stężenia VEGF-A, sVEGFR-2 oraz galektyny-3 w surowicy nie korelują ze stopniem zaawansowania klinicznego ani masą nowotworu u pacjentek z miejscowo zaawansowanym rakiem piersi. Wyjściowe stężenia VEGF-A, sVEGFR-2 i galektyny-3 oraz zaobserwowany wzrost stężeń tych cytokin w surowicy w trakcie chemioterapii nie mają wartości predykcyjnej dla jej skuteczności.
Źródło:
Annales Academiae Medicae Silesiensis; 2022, 76; 96-105
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Lambda-Cyhalothrin - An Insecticide from the Group of Synthetic Pyrethroids - on the Concentrations of NF-ĸB and VEGFR2 in the Liver of Albino Swiss Mice as Markers of its Damage
Wpływ lambda-cyhalothrin - insektycydu z grupy syntetycznych pyretroidów - na stężenia NF-ĸB i VEGFR2 w wątrobie myszy Albino Swiss jako markerów jego uszkodzenia
Autorzy:
Świerszcz, Łukasz
Roszkowska, Anna
Ruszel, Kinga
Wójciak-Czuła, Marta
Borzęcki, Andrzej
Nieradko-Iwanicka, Barbara
Siermontowski, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/32703708.pdf
Data publikacji:
2021
Wydawca:
Polskie Towarzystwo Medycyny i Techniki Hiperbarycznej
Tematy:
lambda-cyhalothrin
nuclear factor ĸB
vascular endothelial growth factor2
liver damage
lambda-cyhalotryna
czynnik jądrowy ĸB
czynnik wzrostu śródbłonka naczyniowego 2
uszkodzenie wątroby
Opis:
Background: Lambda-cyhalothrin (LCH) is a one of the type II synthetic pyrethroids which is widely used in veterinary medicine and in agriculture to protect crops from pest insects. In previous studies, there are few reports about the influence of pyrethroids on the liver and its damage. Analyzing numerous publications, nuclear factor-ĸB (NF-ĸB) and vascular endothelial growth factor 2 (VEGFR2) seem to be sensitive indicators of microdamages occurring at the cellular level in the liver. The aim of the study was to investigate the effect of subacute poisoning with LCH on the concentration of NFĸB and VEGFR2 in the livers. Methods: The experiment was carried on 32 Albino Swiss mice (16 females and 16 males). The animals were divided into 4 groups. Controls received canola oil, the rest received LCH orally in oil at a dose of 2 mg/kg bw for 7 days. The NF-ĸB and VEGFR2 were mesuredin mice livers with ELISA kits. Results: The mean NF-ĸB concektration in control femals’ livers was 3.27ng/mL and after LCH it was 6.12ng/mL (p<0.05). In control males it was 5.49ng/mL and it did not significantly differ after LCH when it was 5.27ng/mL. The mean VEGFR2 in control females was 84.28ng/mL and after LCH it was 173.81ng/mL (p<0.05). In control males it was 170.61ng/mL and after LCH 170.06ng/mL. Conclusion:The NF-ĸB and VEGFR2 can be used as markers of liver damage after subacute poisoning with LCH on female mice. Females are more sensitive to LCH than males.
Wstęp: Lambda-cyhalotryna (LCH) jest jednym z syntetycznych pyretroidów typu II, szeroko stosowanym w weterynarii i rolnictwie do ochrony upraw przed owadami. We wcześniejszych badaniach niewiele jest doniesień o wpływie pyretroidów na wątrobę i jej uszkodzenia. Analizując liczne publikacje, czynnik jądrowy-ĸB (NF-ĸB) i czynnik wzrostu śródbłonka naczyniowego 2 (VEGFR2) wydają się być czułymi wskaźnikami mikrouszkodzeń występujących na poziomie komórkowym w wątrobie. Celem pracy było zbadanie wpływu podostrego zatrucia LCH na stężenie NFĸB i VEGFR2 w wątrobie. Metody: Doświadczenie przeprowadzono na 32 myszach Albino Swiss (16 samic i 16 samców). Zwierzęta podzielono na 4 grupy. Kontrolne grupy samic i samców otrzymywały olej rzepakowy, pozostałe otrzymywały LCH doustnie w oleju w dawce 2 mg/kg mc przez 7 dni. NF-ĸB i VEGFR2 były w wątrobach myszy były mierzone z użyciem zestawów ELISA. Wyniki: Średnie stężenie NF-ĸB w wątrobach kontrolnych samic wynosiło 3,27 ng/ml, a po LCH 6,12 ng/ml (p<0,05). U samców kontrolnych wynosił on 5,49 ng/ml i nie różnił się istotnie po LCH, gdzie wynosił 5,27 ng/ml. Średnie stężenie VEGFR2 u samic z grupy kontrolnej wynosił 84,28 ng/ml, a narażonych na LCH 173,81 ng/ml (p<0,05). U samców z grupy kontrolnej wynosiło 170,61 ng/ml, a narażonych na LCH 170,06 ng/ml. Wniosek: NF-ĸB i VEGFR2 można stosować jako markery uszkodzenia wątroby po podostrym zatruciu LCH u samic myszy. Samice są bardziej wrażliwe na LCH niż samce.
Źródło:
Polish Hyperbaric Research; 2021, 2(75); 57-68
1734-7009
2084-0535
Pojawia się w:
Polish Hyperbaric Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of serum and tissue magnesium, Vascular Endothelial Growth Factor and osteopontin levels in dogs with mammary tumor with/without pulmonary metastases and in healthy dogs
Autorzy:
Gunay Ucmak, Z.
Koenhemsi, L.
Ucmak, M.
Yalcin, E.
Gonul, R.
Ates, A.
Powiązania:
https://bibliotekanauki.pl/articles/1192810.pdf
Data publikacji:
2021
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
canine mammary tumor
magnesium
osteopontin
vascular endothelial growth factor
Opis:
Mammary tumors in female dogs are usually malignant and tend to metastasize to distant organs, especially to regional lymph nodes and lungs. Radiography is the standard diagnostic method to detect pulmonary metastases in these animals. Magnesium (Mg), vascular endothelial growth factor (VEGF), and osteopontin (OPN) levels have been used in recent studies to make prognoses of human breast cancer. To the best of our knowledge, however, there are not many studies that have been performed on this subject, and there is no study on animals in which the three indicators are scrutinized together. The aim of this present study is to evaluate Mg, VEGF, and OPN levels in healthy dogs and in dogs with mammary tumors with/without pulmonary metastases, and to investigate the alterations of these parameters in the serum and tissue samples of dogs with mammary tumors in connection with the histological tumor type and tumor grade. Mammary tumor groups were designed according to the presence of pulmonary metastasis in radiography; group M1 consists of 20 dogs with metastatic mammary tumors to the lung, and group M0 consists of 20 dogs with nonmetastatic mammary tumors. Ten clinically healthy dogs composed group H. The dogs represented different breeds and ages. Threeview thoracic radiographs were taken to determine any metastasis in lungs by digital radiography. Magnesium, VEGF, and OPN were determined in the mammary gland samples and blood serum of 40 dogs with malignant mammary tumors and in 10 healthy dogs. The magnesium levels were measured by atomic absorption spectrophotometry, both in the tissue and serum samples. Also, the tissue and serum VEGF and OPN levels were determined by ELISA with commercially available kits. The tissue Mg levels in the M0 group were significantly (P<0.05) higher than in group H. However, the serum VEGF level was significantly associated with a tumor type. Additionally, the serum OPN levels exhibited a tendency to be higher in dogs with mammary tumors with pulmonary metastases, grade 3, and carcinosarcoma. It is concluded that Mg, VEGF, and OPN could have practical use for diagnosing and understanding the pathophysiology of CMT.
Źródło:
Journal of Elementology; 2021, 26, 1; 125-135
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessing surface fatigue crack growth in railway wheelset axle
Autorzy:
Rudavskyi, D. V.
Kaniuk, Yu. I.
Duriagina, Z. A.
Kulyk, V. V.
Shefer, M. S.
Dolinska, I. Ya.
Powiązania:
https://bibliotekanauki.pl/articles/1818483.pdf
Data publikacji:
2020
Wydawca:
Stowarzyszenie Komputerowej Nauki o Materiałach i Inżynierii Powierzchni w Gliwicach
Tematy:
fatigue crack growth
mixed mode
railway axles
stress intensity factor
estimation model
wzrost pęknięć zmęczeniowych
tryb mieszany
osie kolejowe
współczynnik intensywności naprężeń
model szacowania
Opis:
Purpose: The aim of the proposed research is to create a calculation model of surface fatigue crack growth at the axle of railway wheelset working under operational loads. Design/methodology/approach: The energy approach of the fracture mechanics was used to formulate the calculation model of fatigue crack propagation at the wheelset axle surface. The method of least squares was used to determine the investigated material mechanical constants that the kinetic equations of the calculation model contain. The system of differential equations of crack growth kinetics was solved numerically using the Runge-Kutta method. Findings: On the basis of the energy approach of the fracture mechanics the calculation model of fatigue macrocrack growth in three-dimensional elastic-plastic body in case of a mixed-mode I+II+III macromechanism of fracture has been built. On the basis of the created calculation model, the kinetics of the growth of fatigue cracks was investigated both in the middle part of the wheelset axle and in the axle journal. Research limitations/implications: The results obtained on laboratory specimens should be tested during a real railway wheelset axle investigation. Practical implications: The created calculation model can be used in practice to formulate method of residual lifetime estimation of railway wheelset axle. Originality/value: It was shown, that surface crack kinetics depends not only on the crack initial area but also significantly depends on the crack edge geometry and comparatively small crack-like defects at the wheelset axle surface can reach critical sizes in comparatively short run. It has been found that mechanical shear stresses caused by the weight of the loaded railway wagon in the cross section of the wheelset axle journal can significantly accelerate the growth of the transverse fatigue crack at the axle surface, reducing the period of crack subcritical growth by about 20%.
Źródło:
Archives of Materials Science and Engineering; 2020, 106, 2; 59--67
1897-2764
Pojawia się w:
Archives of Materials Science and Engineering
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
PDGF-BB homodimer serum level – a good indicator of the severity of alcoholic liver cirrhosis
Autorzy:
Kurys-Denis, E.
Prystupa, A.
Luchowska-Kocot, D.
Krupski, W.
Bis-Wencel, H.
Panasiuk, L.
Powiązania:
https://bibliotekanauki.pl/articles/2085441.pdf
Data publikacji:
2020
Wydawca:
Instytut Medycyny Wsi
Tematy:
alcohol
liver cirrhosis
Child-Pugh score
platelet derived growth factor AA
platelet growth factor AB
platelet derived
growth factor BB
Opis:
Introduction. Liver cirrhosis is a chronic disease in which progressive fibrosis is noted. This process leads to changed architectonics of the liver parenchyma and the appearance of regenerative nodules, all of which are caused by pathological activation of the hepatic stellate cells. This process is enhanced on a molecular level by many cytokines, with platelet-derived growth factors (PDGFs) playing the key role. Objective. The aim of the study was to assess serum concentrations of PDGFs active biodymers (PDGF-AA, PDGF-BB and PDGF-AB) in patients with alcoholic liver cirrhosis, and to correlate them with the stage of disease. Materials and method. 64 patients with alcoholic cirrhosis and a control group of 16 healthy individuals were analysed. Liver cirrhosis was determined based on clinical image, history of the patients’ alcohol consumption, laboratory findings and abdominal ultrasonography. The serum PDGF-AA, PDGF-BB and PDGF-AB concentrations were determined using ELISA kits. Results. Serum concentration of PDGF-AA and PDGF-BB homodimers increases in patients with alcoholic liver cirrhosis (p=0.034 and p<0.0001, respectively), unlike the serum concentration of PDGF-AB heterodimer (p>0.05). When the stage of the disease increases, the concentrations of PDGF-AA and PGFD-BB in blood also oncrease. Furthermore, the serum level of both PDGF-AA and PDGF-BB correlates significantly with the severity of alcoholic liver cirrhosis (measured by Pugh-Child’s scale), the correlation being stronger in the case of PDGF-BB levels than PDGF-AA (R=0.28; p=0.027 and R=0.26; p=0.038, respectively). Conclusions. The plasma levels of PDGF-AA and -BB may be indicators of alcohol-induced liver fibrosis process, and might be considered as future possible treatment targets, with PDGF-BB levels being an even better indicator than PDGF-AA levels.
Źródło:
Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 80-85
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effects of adenoidectomy of serum insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children with otitis media with effusion
Autorzy:
Żelazowska-Rutkowska, Beata
Jacewicz, Klaudia
Kasprzycka, Edwina
Skotnicka, Bożena
Cylwik, Bogdan
Powiązania:
https://bibliotekanauki.pl/articles/1397400.pdf
Data publikacji:
2020
Wydawca:
Index Copernicus International
Tematy:
ghrelin
hypertrophied adenoid
insulin-like growth factor-1 (IGF-1)
Opis:
Aim: The aim of the current study was to assess the serum levels of insulin-like growth factor-1 (IGF-1) and ghrelin in hypertrophied adenoids in children suffering with or without otitis media with effusion before and after adenoidectomy. Material and methods: Serum IGF-1 and ghrelin concentrations were measured with specific enzyme-linked immunoassay (ELISA) methods. The study was carried out in 20 children with otitis media with effusion. The reference group comprised 24 children with hypertrophied adenoid, while control group included 19 children. Results: This mean values of IGF-1 in children with otitis media with effusion and children with hypertrophied adenoid before adenoidectomy were significantly lower than those found in healthy children. Serum levels of IGF-1 were higher after adenoidectomy. There was a significant difference of serum ghrelin levels between both examined groups and the control group. Conclusion: Our results suggest that adenoidectomy in children with hypertrophied adenoids and in children with otitis media with effusion significantly increases the level of IGF-1 in serum compared to before surgery through the effect of the GH-IGF-1 axis, which could contribute to children’s growth.
Źródło:
Polish Journal of Otolaryngology; 2020, 74, 4; 13-17
0030-6657
2300-8423
Pojawia się w:
Polish Journal of Otolaryngology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dekompozycje czynnikowe przyrostu wartości dodanej brutto według sekcji PKD i województw
Factor decompositions of gross value added growth by NACE sections and voivodships
Autorzy:
Kotlewski, Dariusz
Powiązania:
https://bibliotekanauki.pl/articles/962826.pdf
Data publikacji:
2019
Wydawca:
Główny Urząd Statystyczny
Tematy:
czynniki produkcji
wynagrodzenie czynników produkcji
zasoby czynników produkcji
total factor productivity
dekompozycje wartości dodanej brutto
zatrudnieni
pracujący
production factors
factor remunerations
factor stocks
total factor productivity
gross value added growth decompositions
employees
employed persons
Opis:
Celem artykułu jest wykazanie, że wykonanie dekompozycji przyrostu wartości dodanej brutto w czterech wariantach umożliwia pogłębienie obserwacji procesów zachodzących w gospodarce. Warianty te uzyskano na podstawie dwóch zasadniczych dychotomii. Pierwsza dotyczyła dekompozycji na kontrybucje wynagrodzeń czynników produkcji z jednej strony oraz na kontrybucje zasobów czynników produkcji i ich produktywności (total factor productivity – TFP) z drugiej strony. Druga polegała na wykonaniu dekompozycji równolegle dla zatrudnionych oraz dla pracujących. Opracowana metodologia umożliwiła dokonanie obliczeń dla lat 2001–2015 na poziomie zagregowanym według sekcji PKD, województw oraz jednocześnie sekcji i województw. Przeprowadzono je na podstawie danych z Banku Danych Lokalnych i rachunków narodowych GUS. Wyniki potwierdzają, że wykonanie dekompozycji według ww. dychotomii umożliwia pogłębienie analiz wzrostu gospodarczego, co jest szczególnie istotne w aspekcie regionalnym.
The aim of this paper is to demonstrate that performing gross value added growth decompositions in four variants makes it possible to deepen the observation of economic processes. These variants have been obtained on the basis of two fundamental dichotomies. The first of them involved performing a decomposition of the gross value added growth into the contributions of production factor remunerations, and, in parallel, a decomposition into the contributions of production factor stocks and total factor productivity (TFP). The second dichotomy involved performing separate but parallel decompositions for employees and for employed persons. The devised methodology made it possible to perform computations for the years 2001–2015 at the aggregate level, according to NACE sections, according to voivodships and according to both the NACE sections and the voivodships. The decompositions were performed basing on Statistics Poland’s data from the Bank of Local Data and the National Accounts. The presented results confirm that performing decompositions according to the two above-mentioned dichotomies makes it possible to deepen the analyses of the economic growth, which is especially important in the regional aspect.
Źródło:
Wiadomości Statystyczne. The Polish Statistician; 2019, 64, 9; 37-59
0043-518X
Pojawia się w:
Wiadomości Statystyczne. The Polish Statistician
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of Natural Aging and Fatigue Crack Propagation Rate on Welded and Non-Welded Aluminum Alloy (AA2219-T87)
Autorzy:
Ijaz, Mudasir
Qayyum, Faisal
Elahi, Hassan
Ullah, Mudaser
Eugeni, Marco
Badshah, Saeed
Gaudenzi, Paolo
Powiązania:
https://bibliotekanauki.pl/articles/102921.pdf
Data publikacji:
2019
Wydawca:
Stowarzyszenie Inżynierów i Techników Mechaników Polskich
Tematy:
natural aging
AA2219
crack growth rate
structure health
fatigue
microstructure
stress intensity factor
naturalne starzenie się
tempo wzrostu pęknięć
zmęczenie
mikrostruktura
współczynnik intensywności stresu
Opis:
Aluminum alloys are widely used for fabrication of aircraft, civil structures, and space vehicles. Fatigue life consideration of a material is the most important design criteria in many such critical applications. In this research work, a widely used Aluminum alloy AA2219-T87 was TIG welded using AA2319 as a filler material. The effect of natural aging on Fatigue Crack Propagation Rate (FCPR) of welded and non-welded compact tension (CT) specimens (AA2219˗T87) is studied. The relationship between stress intensity factor (ΔK) and crack ratio (a/W) for different value of the crack length in base metal and the welded zone is presented. Paris curves for both welded and non-welded specimens and compared to study the effect of natural aging (NA) on FCGR and compared with non-aged specimens. The results obtained provide a base for the development of Structural Health Monitoring systems for the propagation of crack growth in such components.
Źródło:
Advances in Science and Technology. Research Journal; 2019, 13, 3; 129-143
2299-8624
Pojawia się w:
Advances in Science and Technology. Research Journal
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Nierówności ekonomiczne a pułapka średniego poziomu rozwoju. Wnioski dla Polski
Economic inequality and the middle-income trap. Implications for Poland
Autorzy:
Kowalski, Ryszard
Powiązania:
https://bibliotekanauki.pl/articles/2127622.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet w Białymstoku. Wydawnictwo Uniwersytetu w Białymstoku
Tematy:
teoria wzrostu gospodarczego
pułapka średniego poziomu rozwoju
łączna produktywność czynników wytwórczych
nierówności ekonomiczne
growth theory
middle income trap
total factor productivity
economic inequality
Opis:
Cel – W pracy scharakteryzowano kontrowersje definicyjne związane z empirycznym ujęciem zjawiska pułapki średniego poziomu rozwoju, zbadano relacje zachodzące między nierównościami ekonomicznymi a pułapką średniego poziomu rozwoju oraz oceniono znaczenie nierówności jako potencjalnej bariery dla wzrostu gospodarczego w Polsce w długookresowej perspektywie. Metoda badań – Do oceny wpływu nierówności na wzrost gospodarczy i ich znaczenia jako czynnika ryzyka dla trwałości wzrostu gospodarczego w Polsce wykorzystano metodę analizy i krytyki piśmiennictwa oraz posłużono się danymi statystycznymi publikowanymi przez OECD. Wyniki – Ograniczenia empirycznych ujęć zjawiska pułapki są związane z arbitralnością założeń dotyczących okresu oraz poziomu dochodu wyznaczających uwięzienie kraju w pułapce średniego poziomu dochodu. Analiza wykazała, że większość spowolnienia wzrostu gospodarczego w przypadku krajów „złapanych” w pułapkę wynika z obniżenia wzrostu łącznej produktywności czynników wytwórczych oraz że duże nierówności ekonomiczne negatywnie oddziałują na determinanty produktywności, w konsekwencji na wzrost gospodarczy. Ze względu na umiarkowany poziom nierówności dochodowych wydaje się jednakże, że w przypadku Polski większe znaczenie mogą mieć inne wewnętrzne bariery wzrostu niż nierówności. Oryginalność/wartość – Świadomość roli, jaką nierówności ekonomiczne pełnią w procesie wzrostu łącznej produktywności czynników wytwórczych, ma kluczowe znaczenie dla wypracowania odpowiednich rozwiązań w zakresie polityki publicznej, służących uniknięciu pułapki.
Purpose – This paper examines empirical controversies about the middle-income trap concept and presents the analysis of the relationship between economic inequality and the middle income trap. It also discusses the significance of inequality as a potential barrier for Poland’s economic growth in the long-term perspective. Research method – A critical literature review and data from OECD statistics database were used to assess the impact of inequalities on economic growth and the significance of inequality as a risk factor for Poland’s economic growth. Results – Empirical approaches are subject to the limitations as they rely on arbitrary assumptions to define time and income thresholds when assessing whether a country is caught in a middle-income trap. The analysis shows that the growth slowdown in the countries “trapped” at the middle-income level result mainly from the slowdown of the total factor productivity growth and that high levels of inequality have negative impact on productivity determinants, therefore on growth. However, given the moderate level of income inequality, it seems that in the case of Poland some other internal barriers to growth are among the most important ones. Originality/value – Understanding the role of economic inequality in explaining total factor productivity growth is crucial in devising appropriate policy measures that may help to avoid the middle-income trap.
Źródło:
Optimum. Economic Studies; 2019, 2(96); 37-52
1506-7637
Pojawia się w:
Optimum. Economic Studies
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of the compliance of aircraft wing flap with use of the fracture mechanics
Autorzy:
Kłysz, S.
Baran, M.
Powiązania:
https://bibliotekanauki.pl/articles/243350.pdf
Data publikacji:
2018
Wydawca:
Instytut Techniczny Wojsk Lotniczych
Tematy:
airplane wing flap
crack growth
stress intensity factor
Irwin-Kies theory
Opis:
Research in the field of fracture mechanics and determination of material characteristics are used for practical purposes, such as the assessment of static and dynamic strength of structural components, analysis of their fatigue life or extending the life span of their operation. A structural component, considered to be safe from fatigue cracking point of view, was investigated and results were presented in this article. In particular, an analysis was made to determine the stress intensity factor for the cracked wing flap construction, based on static and fatigue tests, using the Irwin-Kies theory. The flap with a service crack was subjected to fatigue tests with a load similar to the one registered during flight measurements. The flap without a service crack was subjected to static tests, after cutting the cracks of specified lengths and shapes (similar to the service crack) in the skin of the flap. The article presents changing the length of the flap crack in subsequent load cycles, change in the maximum values of force and the crack opening displacement in subsequent load cycles, dependence of P-COD in the first and second stage of fatigue testing of the wing flap, dependence of the wing flap compliance on the length of the crack and experimentally determined dependence for wing flap. The occurrence of a flap crack up to approximately 230 mm does not cause a significant growth of the stress intensity factor.
Źródło:
Journal of KONES; 2018, 25, 4; 547-554
1231-4005
2354-0133
Pojawia się w:
Journal of KONES
Dostawca treści:
Biblioteka Nauki
Artykuł
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