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Wyszukujesz frazę "genetic susceptibility" wg kryterium: Temat

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    Wyświetlanie 1-5 z 5
    Tytuł:
    The value of pedigrees and clinical assessment in identification of a high risk cancer group – our experience
    Autorzy:
    Jaworowska, Ewa
    Powiązania:
    https://bibliotekanauki.pl/articles/1400526.pdf
    Data publikacji:
    2016
    Wydawca:
    Index Copernicus International
    Tematy:
    laryngeal cancer
    genetic susceptibility
    risk factors
    pedegrees
    Opis:
    Pedigree and clinical data are still very important diagnostic tool useful in estimation of a high risk of a cancer devel-opment, molecular basis research and also determining optimal screening for a single family. In this study the own experience was presented in identification of the risk of cancer prevalence with different organ location among the first degree relatives of 760 patients with laryngeal cancer.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2016, 5, 2; 51-56
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Gene-occupation interactions: a review of the literature on bladder and prostate cancer
    Autorzy:
    Wieczorek, Edyta
    Wolniakowska, Anna
    Roszak, Joanna
    Rodrigues, Robim M.
    Vanhaecke, Tamara
    Reszka, Edyta
    Powiązania:
    https://bibliotekanauki.pl/articles/2203023.pdf
    Data publikacji:
    2023-05-19
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    bladder cancer
    gene
    genetic susceptibility
    occupational exposure
    prostate cancer
    workplace
    Opis:
    Bladder cancer (BCa) and prostate cancer (PCa) are genitourinary cancers which constitute significant health problems in men and in which environmental factors play an important role. Understanding the genetic susceptibility to BCa or PCa and occupational exposure is paramount to improving cancer prevention and early detection. The aim of this review article was to address the scientific evidence on the genetic risk factors and occupational exposure associated with the occurrence of BCa and PCa. The authors identified relevant original articles that have been published between 1994 and 2023. Variations of the following search terms: “gene” and “occupational” combined with one of the following terms: “bladder cancer” or “prostate cancer” were applied for the search purpose. The authors found 342 publications of which 50 population studies met their requirements for gene-occupation interactions. In total, 34 full-text manuscripts were about BCa and 16 about PCa. These research examines the genes involved in detoxification processes of xenobiotics (glutathione S-transferase, N-acetyltransferase, cytochrome P450, UDP-glucuronosyltransferase), oxidative stress (glutathione peroxidase 1, manganese superoxide dismutase, catalase), altering DNA repair capacity (X-ray repair cross-complementing 1, base excision repair, nucleotide excision repair), tumour suppression (TP53 gene), and vitamin D pathway (vitamin D receptor gene). The role of genetic factors in the occupational exposure has not been conclusively established, but it appears the possibility of genetic involvement. Determination of environmentally responsive genes provides important mechanistic implications for the etiology of occupational cancers, and valuable input in occupational exposure limits set by taking genetic susceptibility into account. More genetic research is needed to corroborate these findings and assess their significance in the workplace. Med Pr. 2023;74(2):127–44
    Źródło:
    Medycyna Pracy; 2023, 74, 2; 127-144
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stochastic Models of Progression of Cancer and Their Use in Controlling Cancer-Related Mortality
    Autorzy:
    Kimmel, M.
    Gorlova, O. Y.
    Powiązania:
    https://bibliotekanauki.pl/articles/908159.pdf
    Data publikacji:
    2003
    Wydawca:
    Uniwersytet Zielonogórski. Oficyna Wydawnicza
    Tematy:
    medycyna
    statystyka
    lung cancer
    genetic susceptibility
    environmental exposure
    tumor growth
    statistical modeling
    simulation
    Opis:
    A construction of a realistic statistical model of lung cancer risk and progression is proposed. The essential elements of the model are genetic and behavioral determinants of susceptibility, progression of the disease from precursor lesions through early (localized) tumors to disseminated disease, detection by various modalities, and medical intervention. Using model estimates as a foundation, mortality reduction caused by early-detection and intervention programs can be predicted under different scenarios. Genetic indicators of susceptibility to lung cancer should be used to define the highest-risk subgroups of the high-risk behavior population (smokers). The calibration and validation of the model requires applying our techniques to a variety of data sets available, including public registry data of the SEER type, data from the NCI lung cancer chest X-ray screening studies, and the recent ELCAP CT-scan screening study.
    Źródło:
    International Journal of Applied Mathematics and Computer Science; 2003, 13, 3; 279-287
    1641-876X
    2083-8492
    Pojawia się w:
    International Journal of Applied Mathematics and Computer Science
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Genetic algorithm combined with a local search method for identifying susceptibility genes
    Autorzy:
    Yang, C -H.
    Moi, S. -H.
    Lin, Y. -D.
    Chuang, L. -Y.
    Powiązania:
    https://bibliotekanauki.pl/articles/91586.pdf
    Data publikacji:
    2016
    Wydawca:
    Społeczna Akademia Nauk w Łodzi. Polskie Towarzystwo Sieci Neuronowych
    Tematy:
    genetic algorithms
    identifying susceptibility genes
    local search algorithm
    Opis:
    Detecting genetic association models between single nucleotide polymorphisms (SNPs) in various disease-related genes can help to understand susceptibility to disease. Statistical tools have been widely used to detect significant genetic association models, according to their related statistical values, including odds ratio (OR), chi-square test (χ2), p-value, etc. However, the high number of computations entailed in such operations may limit the capacity of such statistical tools to detect high-order genetic associations. In this study, we propose lsGA algorithm, a genetic algorithm based on local search method, to detect significant genetic association models amongst large numbers of SNP combinations. We used two disease models to simulate the large data sets considering the minor allele frequency (MAF), number of SNPs, and number of samples. The three-order epistasis models were evaluated by chi-square test (χ2) to evaluate the significance (P-value < 0.05). Analysis results showed that lsGA provided higher chi-square test values than that of GA. Simple linear regression indicated that lsGA provides a significant advantage over GA, providing the highest β values and significant p-value.
    Źródło:
    Journal of Artificial Intelligence and Soft Computing Research; 2016, 6, 3; 203-212
    2083-2567
    2449-6499
    Pojawia się w:
    Journal of Artificial Intelligence and Soft Computing Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zmienność w skłonności do stanów zapalnych wymion
    Izmenchivost' v sklonnosti ovec k vospalitel'nym processam vymeni
    Changes in susceptibility of sheep to the udder inflammation processes
    Autorzy:
    Zarzycki, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/796814.pdf
    Data publikacji:
    1988
    Wydawca:
    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie. Wydawnictwo Szkoły Głównej Gospodarstwa Wiejskiego w Warszawie
    Tematy:
    hodowla zwierzat
    owce
    choroby zwierzat
    zapalenie gruczolu mlekowego
    wymiona
    czynniki genetyczne
    stan zdrowotny
    animal breeding
    sheep
    animal disease
    mastitis
    udder
    genetic factor
    susceptibility
    inflammation
    health status
    Opis:
    Исследовали молоко овец трех пород: польской мериносовой овцы, низинной овцы и польской горной овцы. Установлены существенные различия в содержании сомантически клеток в малоке меринасовых и низинных овец. Смамистически существенные различия (р ≥ 0,05) у исследуемых пород наблюдались между очередными лактациями. С возрастом (очередной лактацией) в овечьем молоке повышалось количество клеточных элементов. Установлено существенное различие (р = 0,05) в склонности овец указанных пород к болезням в зависимости от их происхождения после отдельных баранов. Оцененный разными методами коэффициент наследуемости среднего состояния вымени был сходным, составляя около h² = ≈ 0,2, однако он сопровождался высокой погрешностью.
    Milk of Polish Merino sheep, lowland sheep of the Żelazna variety and Polish mountain sheep was investigated. A significant difference in the content of somatic cells in the milk of Merino and lowland ewes has been found. A statistically significant difference (p ≥ 0,05) in the above breeds was observed between subsequent lactations. The amount of cell elements increased in the milk along with the advancing age (subsequent lactations). A significant difference (p = 0,05) in susceptibility to the udder diseases of ewes of the three breeds tested depending on their origin from particular rams has been proved. The heritability coefficient of average state of the udder was similar amounting to h² = ≈ 0.2, still it was accompanied by a high error.
    Źródło:
    Zeszyty Problemowe Postępów Nauk Rolniczych; 1988, 352
    0084-5477
    Pojawia się w:
    Zeszyty Problemowe Postępów Nauk Rolniczych
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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