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    Wyświetlanie 1-8 z 8
    Tytuł:
    Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects
    Autorzy:
    Serrano, José
    Cipak, Ana
    Boada, Jordi
    Gonzalo, Hugo
    Cacabelos, Daniel
    Cassanye, Anna
    Pamplona, Reinald
    Zarkovic, Neven
    Portero-Otin, Manuel
    Powiązania:
    https://bibliotekanauki.pl/articles/1040403.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    gallic acid
    peroxidase
    pro-oxidant
    antioxidant
    HMEC-1
    Opis:
    A previous report from our group had shown in vitro a direct interaction between peroxidases and dietary antioxidants at physiological concentrations, where in the absence of H2O2, the antioxidants could serve as oxidizing substrates for the peroxidases. However, the physiological relevance of those findings had not been evaluated. The main objective of this study was to determine whether the oxidizing products produced in the interaction between peroxidase and gallic acid at a physiological concentration of 1 µM may promote cell death or survival in a human microvascular endothelial cell line (HMEC-1). Our findings suggested that gallic acid may show a double-edged sword behaviour, since in the absence of H2O2 it may have a pro-oxidant effect which may promote cell injury (evidenced by LDH, Crystal Violet and calcein AM viability/citotoxicity assays), while in the presence of H2O2, gallic acid may act as an antioxidant inhibiting oxidative species produced in the peroxidase cycle of peroxidases. These observations were confirmed with several oxidative stress biomarkers and the evaluation of the activation of cell survival pathways like AKT and MAPK/ERK.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 2; 193-198
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mikrobiologiczny rozkład kwasu galusowego
    Microbiological degradation of gallic acid
    Autorzy:
    Wojcieszyńska, D.
    Guzik, U.
    Jaroszek, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/297528.pdf
    Data publikacji:
    2009
    Wydawca:
    Politechnika Częstochowska. Wydawnictwo Politechniki Częstochowskiej
    Tematy:
    kwas galusowy
    bakterie
    degradacja
    gallic acid
    bacteria
    degradation
    Opis:
    Kwas galusowy należy do grupy roślinnych związków zwanych polifenolami. Związek ten występuje w roślinach w postaci wolnej i związanej w estrach. Rozkład GA zachodzi zarówno w tlenowych, jak i beztlenowych warunkach, a główną rolę w jego degradacji odgrywają mikroorganizmy. Kluczowymi enzymami tlenowej degradacji GA są, należące do oksygenaz, dioksygenazy rozszczepiające, katalizujące rozpad pierścienia aromatycznego z udziałem tlenu. Tlenowa degradacja kwasu galusowego u bakterii może zachodzić szlakiem meta, inicjowanym przez dioksygenazę galusanową i 4,5-dioksygenazę protokatechową, lub szlakiem orto, zapoczątkowanym aktywnością 3,4-dioksygenazy protokatechowej. Produktami rozkładu GA stwierdzonymi u Pseudomonas putida są pirogronian i szczawiooctan. Rozkład GA z udziałem tlenu powiązany jest również ze szlakiem ß-ketoadypinowym kwasu protokatechowego, którego końcowymi produktami są acetylo-CoA i bursztynylo-CoA. Stwierdzono także obecność tlenowej degradacji GA u grzybów. Głównymi związkami przejściowymi beztlenowej degradacji GA są floroglucyna oraz rezorcyna. Kluczowym produktem przejściowym w degradacji kwasu galusowego poprzez floroglucynę jest 3-hydroksy-5-ketoheksanian (HOHN). Rezorcyna, drugi produkt przejściowy beztlenowej degradacji GA, powstaje z floroglucyny i pirogalolu przez dehydroksylację. Związek ten może ulegać następnie redukcji z udziałem reduktazy rezorcynowej lub hydrolizie do kwasu 5-keto-2-heksenowego.
    Gallic acid (3,4,5-trihydroxybenzoic acid) is widely distributed throughout the plant kingdom. It is present in almost all plants. High gallic acid contents can be found in gallnuts, grapes, tea, hops and oak bark. According to its biochemical properties gallic acid is an industrially important chemical used as an antioxidant in food, cosmetics and pharmaceutical industries. It possesses a lot of potential therapeutic properties including anti-cancer and antimicrobial ones. The gallic acid is readily utilized by oxidative breakdown to simple aliphatic acids that are metabolized through the citric acid cycle. Although different aerobic pathways for the aromatic acids biodegradation are known they usually involve the formation of protocatechuate as a common intermediate. Protocatechuate may be cleaved by protocatechuate 3.4- dioxygenase [EC 1.13.11.3], which catalyzes the intradiol addition of molecular oxygen and forms 2-pyrone-4,6-dicarboxylic acid as well as protocatechuate 4.5-dioxygenase [1.13.11.8] that catalyzes extradiol addition of molecular oxygen result in 4-carboxy-2-hydroxy-cis,cis-muconic semialdehyde formation. Another mechanism of gallic acid degradation is observed in fungi. In Aspergillus niger gallic acid is oxidatively cleaved by an oxygenase to unstable tricarboxylic intermediate decarboxylated by an oxidative decarboxylase to cis-aconitic acid enter the citric acid cycle. Aspergillus flavus degrades gallic acid to oxaloacetic acid and finally pyruvic acid through the tricarboxylic acid intermediates. Different mechanisms of anaerobic breakdown of gallic acid are known. At the first step of its degradation gallate is decarboxylated to 1,2,3-trihydroxybenzene, which is isomerized to phloroglucinol by pyrogallol-phloroglucinol isomerase and then reduced to dihydrophloroglucinol by phloroglucinol reductase. In the next step dihydrophloroglucinol is converted to 3-hydroxy-5-oxohexanonic acid (HOHN) by dihydrophloroglucinol hydrolase. Then, HOHN may be degraded through different pathways. The first one is its conversion to 3,5-dioxohexanoate (triacetate) by HOHN dehydrogenase and ultimately to three molecules of acetyl-CoA via triacetyl-CoA by the sequential enzymatic reactions catalyzed by triacetyl-CoA transferase, triacetate-ketothiolase, acetoacetyl-CoA-ketothiolase, phosphotransacetylase and acetate kinase. In methanogenic conditions HONH-CoA is transformed to butyrate or acetate, which are finally degraded to methane and carbon dioxide.
    Źródło:
    Inżynieria i Ochrona Środowiska; 2009, 12, 3; 173-184
    1505-3695
    2391-7253
    Pojawia się w:
    Inżynieria i Ochrona Środowiska
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Formulation and Stability of Cellulose Particles Enriched with Phenolic Acids
    Autorzy:
    Kopjar, Mirela
    Vukoja, Josipa
    Buljeta, Ivana
    Ćorković, Ina
    Pichler, Anita
    Šimunović, Josip
    Powiązania:
    https://bibliotekanauki.pl/articles/24024620.pdf
    Data publikacji:
    2023-11-06
    Wydawca:
    Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk w Olsztynie
    Tematy:
    cellulose
    gallic acid
    caffeic acid
    storage stability
    antioxidant potential
    complexation
    Opis:
    Dietary fibers and phenolic acids are recognized for their various health benefits; thus, cellulose was selected as a carrier polymer of phenolic acids, including gallic acid and caffeic acid. Dried cellulose particles were prepared through the complexation of different amounts of cellulose (2.5, 5, 7.5 and 10%, w/v) with a constant amount of phenolic acids. Additionally, the complexation time was 15 or 60 min with the goal to determine an impact of the duration of complexation on the adsorption of phenolic acids onto cellulose. The prepared particles were stored at ambient temperature for 12 months to assess their storage stability. Cellulose particles were assessed for the amount of adsorbed phenolic acids and antioxidant activities. For both phenolic acids, the same correlation was established, i.e., reduction of adsorption of phenolic acids occurred with the increase of cellulose amount during complexation. The duration of complexation was not a significant factor in the adsorption of phenolic acids. Antioxidant activity generally followed the trend that was obtained for the amount of adsorbed phenolic acids. Comparing both phenolic acids, cellulose had a higher affinity for caffeic acid (4.665 g/kg) than for gallic acid (3.399 g/kg). However, greater stability of gallic acid/cellulose particles was observed throughout the storage. After storage, the content of gallic acid in cellulose particles slightly decreased (up to 3%), while that of caffeic acid decreased from 10 to 20%. The complexation of phenolic acids with cellulose was proven by recording infrared spectra. Formulated cellulose particles can be a valuable tool for the preparation of plant-based functional additives which can be used for the enrichment of products with phenolic acids in order to improve their antioxidant potential and stability.
    Źródło:
    Polish Journal of Food and Nutrition Sciences; 2023, 73, 4; 322-331
    1230-0322
    2083-6007
    Pojawia się w:
    Polish Journal of Food and Nutrition Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis and properties of model humic substances derived from gallic acid
    Autorzy:
    Slawinska, D.
    Polewski, K.
    Rolewski, P.
    Slawinski, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/25730.pdf
    Data publikacji:
    2007
    Wydawca:
    Polska Akademia Nauk. Instytut Agrofizyki PAN
    Tematy:
    humic acid
    humic substance
    gallic acid
    antioxidant
    high performance liquid chromatography
    Źródło:
    International Agrophysics; 2007, 21, 2
    0236-8722
    Pojawia się w:
    International Agrophysics
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Potent antifungal properties of gallic acid in Sarcochlamys pulcherrima against Candida auris
    Autorzy:
    Akhtar, Nahid
    Mannan, M. Amin-Ul
    Pandey, Deeksha
    Sarkar, Amon
    Sharma, Himanshi
    Kumar, Manish
    Ghosh, Anup
    Powiązania:
    https://bibliotekanauki.pl/articles/16698568.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    Sarcochlamys pulcherrima
    antifungal
    gallic acid
    Candia auris
    molecular docking
    carbonic anhydrase
    Opis:
    Candida auris is a major public health concern due to its high transmission and mortality rates, as well as the emergence of pan-resistant strains. This study aimed to identify an antifungal compound from Sarcochlamys pulcherrima , an ethnomedicinal plant, that can inhibit the growth of C. auris. Methanol and ethyl acetate extracts of the plant were obtained, and high-performance thin-layer chromatography (HPTLC) analysis was conducted to identify the major compounds in the extracts. The major compound detected by HPTLC was subjected to in vitro antifungal activity testing, and its antifungal mechanism was determined. The plant extracts inhibited the growth of both C. auris and Candida albicans. HPTLC analysis revealed the presence of gallic acid in the leaf extract. Furthermore, the in vitro antifungal assay showed that gallic acid inhibited the growth of different C. auris strains. In silico studies indicated that gallic acid can bind to the active sites of carbonic anhydrase (CA) proteins in both C. auris and C. albicans, affecting their catalytic activities. Compounds that target virulent proteins such as CA can aid in the reduction of drug-resistant fungi and the development of novel antifungal compounds with unique modes of action. However, additional in vivo and clinical studies are required to conclusively determine gallic acid’s antifungal properties. Gallic acid derivatives may be developed in the future to possess more potent antifungal properties and target various pathogenic fungi.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2023, 104, 2; 105-119
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Physicochemical parameters effect on biosynthesis and properties of copper nanoparticles
    Autorzy:
    Pawlowska, Agnieszka
    Kazmierczak, Michal
    Sadowski, Zygmunt
    Powiązania:
    https://bibliotekanauki.pl/articles/110884.pdf
    Data publikacji:
    2019
    Wydawca:
    Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
    Tematy:
    gallic acid
    green tea extract
    particle size
    polyphenols
    zeta potential
    aerobic conditions
    nitrogen atmosphere
    Opis:
    Plant extract obtained from green tea was used for the synthesis of nanoparticles under anaerobic and aerobic conditions at various ratios of the copper solution to the extract used. The smallest nanoparticles were obtained at a ratio of 1:10. The nanoparticles showed the maximum negative value of the zeta potential around pH 6. An increase in the temperature of reaction caused a decrease in the negative zeta potential value. Synthesis under nitrogen atmosphere favours the formation of smaller copper nanoparticles.
    Źródło:
    Physicochemical Problems of Mineral Processing; 2019, 55, 6; 1460-1466
    1643-1049
    2084-4735
    Pojawia się w:
    Physicochemical Problems of Mineral Processing
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Comparative effects of selected plant polyphenols, gallic acid and epigallocatechin gallate, on matrix metalloproteinases activity in multidrug resistant MCF7/DOX breast cancer cells
    Autorzy:
    Nowakowska, Anna
    Tarasiuk, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/1038784.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    phenolic compounds
    gallic acid
    epigallocatechin gallate
    matrix metalloproteinases
    human breast cancer MCF7 cells
    multidrug resistance MDR
    Opis:
    The aim of the study was to investigate the effect of selected polyphenols: gallic acid (GA) and epigallocatechin gallate (EGCG) on matrix metalloproteinase (MMP-2 and MMP-9) activity in multidrug resistant (MDR) human breast adenocarcinoma cells: MCF7/DOX cells and obtained recently in our laboratory MCF7/DOX500 cells by the permanent selection of MCF7/DOX cells with 500 nM doxorubicin (DOX). The activity of MMP-2 and MMP-9 and the effect of studied polyphenols on these matrix proteases were examined by gelatin zymography assays. We have found that the activity of MMP-2 and MMP-9 significantly increased in resistant MCF7/DOX and MCF7/DOX500 cells whereas they were not detected in sensitive MCF7 cells. It was also observed that GA (30, 60, 100 and 120 µM) and EGCG (5, 10 and 20 µM) caused a comparable concentration-dependent inhibition of MMP-2 and MMP-9 activity in MCF7/DOX and MCF7/DOX500 cells. Control experiments confirmed that examined compounds in these ranges of concentration did not affect the cell growth of MCF7/DOX and MCF7/DOX500 sublines (80-100% of control cell growth was observed in the presence of studied polyphenols).
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 3; 571-575
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Determination of chlorogenic and gallic acids by UPLC-MS/MS
    Oznanczanie zawartości kwasu chlorogenowego i galusowego za pomocą UPLC-MS/MS
    Autorzy:
    Gryszczynska, A.
    Opala, B.
    Lowicki, Z.
    Krajewska-Patan, A.
    Buchwald, W.
    Czerny, B.
    Mielcarek, S.
    Boron, D.
    Bogacz, A.
    Mrozikiewicz, P.M.
    Powiązania:
    https://bibliotekanauki.pl/articles/72301.pdf
    Data publikacji:
    2013
    Wydawca:
    Instytut Włókien Naturalnych i Roślin Zielarskich
    Tematy:
    determination
    chlorogenic acid
    gallic acid
    Rhodiola kirilowii
    Rhodiola rosea
    polyphenolic acid
    plant extract
    ultra performance liquid chromatography-tandem mass spectrometric method
    analytical method
    Opis:
    The aim of our study were qualitative and quantitative analyses of two polyphenolic acids: chlorogenic and gallic acids. These compounds were determined in two species of Rhodiola: R. kirilowii and R. rosea. After collecting plants, aqueous and hydroalcoholic extracts were prepared. In order to identify analysed polyphenolic compounds ultra performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS, Waters) was used. Gallic acid is commonly found in the roots of these plants. Aqueous extract in both species is a rich source of gallic acid. The UPLC-MS/MS studies allow to use this analytical method for determination of polyphenolic acids accordance with the requirements of ICH. Chromatographic method developed by our team is more precise then previously published.
    W Instytucie Włókien Naturalnych i Roślin Zielarskich podjęto badania mające na celu opracowanie metody detekcji kwasu chlorogenowego oraz galusowego za pomocą ultrasprawnej chromatografii cieczowej sprzężonej z tandemowym spektrometrem mas (UPLCMS/ MS, Waters). Badaniom poddano dwa gatunki różnica: Rhodiola kirilowii oraz R. rosea. Rośliny zostały wyhodowane w uprawie gruntowej w Instytucie. Przeprowadzona walidacja metody pozwoliła na jej wykorzystanie w ocenie zawartości kwasu chlorogenowego oraz galusowego w badanych roślinach, ponieważ zawartość analizowanych związków zależna jest zarówno od gatunku jak i warunków uprawy.
    Źródło:
    Herba Polonica; 2013, 59, 1
    0018-0599
    Pojawia się w:
    Herba Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-8 z 8

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