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Tytuł:
Effects of wheat germ agglutinin and concanavalin A on the accumulation of glycosaminoglycans in pericellular matrix of human dermal fibroblasts. A comparison with insulin.
Autorzy:
Yevdokimova, Natalia
Yefimov, Andrej
Powiązania:
https://bibliotekanauki.pl/articles/1044154.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
human dermal fibroblasts
insulin
concanavalin A
peanut agglutinin
glycosaminoglycans
wheat germ agglutinin
Opis:
The effect of insulin, wheat germ agglutinin (WGA), peanut agglutinin (PNA) and concanavalin A (ConA) on [3H]glucosamine incorporation into pericellular glycosaminoglycans (GAGs) was investigated in two lines of cultured human dermal fibroblasts. Insulin and WGA stimulated [3H]glucosamine incorporation into hyaluronic acid (HA) and heparan sulphate (HS) without any alteration of chondroitin sulphate (CS) and dermatan sulphate (DS) contents. ConA increased [3H]glucosamine incorporation into HS, CS and DS, but had no effect on [3H]glucosamine incorporation into HA. PNA affected neither the content, nor the composition of GAGs. In contrast to PNA, ConA and WGA stimulated glycolysis and demonstrated an evident antiproliferative effect on dermal fibroblasts. Thus, both the insulin-like action of WGA and ConA on cultured dermal fibroblasts and the differences between the effects of lectins on modulation of GAGs synthesis appear to be determined by their chemical structure.
Źródło:
Acta Biochimica Polonica; 2001, 48, 2; 563-572
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of fractionated radiation on proliferation, cell cycle and apoptosis of normal human dermal fibroblasts
Autorzy:
Adamczyk, A.
Gasińska, A.
Powiązania:
https://bibliotekanauki.pl/articles/147800.pdf
Data publikacji:
2005
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
fibroblasts
fractionated irradiation
proliferation
radiosensitivity
Opis:
The aim of the study was to investigate the changes in proliferation rate, cell cycle and apoptosis of normal skin fibroblasts during fractionated irradiation with a fraction dose of 2 Gy. Fibroblasts were irradiated 5 days per week for 12 days using gamma irradiation. Twenty four hours after each fraction, and for three days after finishing experiment the cells were harvested, fixed, and BrdUrd labelling index (BrdUrdLI), cell cycle and level of apoptosis and debris were assessed. It was found that fractionated irradiation caused disturbances in the proliferation rate and the cell cycle. Irradiation caused also constant, statistically significant increase in the number of G2M cells and level of apoptosis and debris, which was observed even during 3 days after irradiation. Data indicate non equal biological effect of each fraction dose. Block at G2/M phase suggests accumulation of sublethal damage and increased radiosensitivity, which was manifested by elevated level of cell death (apoptosis and debris).
Źródło:
Nukleonika; 2005, 50,suppl.2; 9-12
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ocena biozgodności bioresorbowalnych materiałów polimerowych wobec ludzkich fibroblastów
Biocompatibility of biodegradable synthetic polymers for human fibroblasts
Autorzy:
Orchel, A.
Jelonek, K.
Kasperczyk, J.
Dobrzyński, P.
Orchel, J.
Dzierżewicz, Z.
Powiązania:
https://bibliotekanauki.pl/articles/284034.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bioresorbowalne materiały polimerowe
biozgodność
fibroblasty
biodegradable synthetic polymers
biocompatibility
fibroblasts
Źródło:
Engineering of Biomaterials; 2008, 11, no. 81-84; 5-8
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Photodynamic effect of protoporphyrin diarginate (PPArg2) on methicillin-resistant Staphylococcus aureus and human dermal fibroblasts
Autorzy:
Grinholc, Mariusz
Kawiak, Anna
Kurlenda, Julianna
Graczyk, Alfreda
Bielawski, Krzysztof
Powiązania:
https://bibliotekanauki.pl/articles/1040819.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cytotoxicity
antimicrobial photodynamic inactivation
MRSA
fibroblasts
phototoxicity
Opis:
The worldwide rise in the antibiotic resistance of bacteria forces the development of alternative antimicrobial treatments. A potential approach is photodynamic inactivation (PDI). The aim of the present study was to determine the phototoxicity of protoporphyrin diarginate (PPArg2) against methicillin-resistant Staphylococcus aureus and human dermal fibroblasts. Different concentrations (0 to 20 µM) of PPArg2 and light dose of 6 J cm-2 were tested. Cell viability was evaluated using the methylthiazoletetrazolium (MTT) assay. Incubation with 10 µM followed by illumination yielded a 3.6 log10-unit reduction in the viable count for Staphylococcus aureus. At the same experimental conditions, only 22.5% of the fibroblasts were photoinactivated. Protoporphyrin diarginate at concentrations up to 20 µM demonstrated no toxicity towards S. aureus or fibroblasts when not irradiated. These results suggest that the protoporphyrin diarginate exerts a high bactericidal effect against methicillin-resistant S. aureus strain without harming eukaryotic cells.
Źródło:
Acta Biochimica Polonica; 2008, 55, 1; 85-90
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ biomateriałów na przyleganie i aktywność mysich fibroblastów L929
Effects of biomaterials on adhesion and activity of murine fibroblasts L929
Autorzy:
Ścisłowska-Czarnecka, A.
Pamuła, E.
Płytycz, B.
Kołaczkowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/285238.pdf
Data publikacji:
2008
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
biomateriały
fibroblasty
przeszczepy chirurgiczne
biomaterials
fibroblasts
transplantation
Źródło:
Engineering of Biomaterials; 2008, 11, no. 81-84; 83-86
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Fibroblast biological activity on poly(l-lactide) and poly(l-lactide-co-trimethylene carbonate)
Autorzy:
Ścisłowska-Czarnecka, A.
Pamuła, E.
Kołaczkowska, E.
Powiązania:
https://bibliotekanauki.pl/articles/284073.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
fibroblasts
biomaterials
PLLA
Opis:
Poly-L-lactide (PLLA) is acknowledged biocompatible polyester. However, it possesses high crystallinity/brittleness/stiffness and requires long time for complete degradation. In the current study we present data on PLTMC, a copolymer of L-lactide and trimethylene carbonate (TMC). Poly(trimethylene carbonate) (PTMC) is characterised by good mechanical properties and rapid degradation rate and for this it might possess new desired features for medical applications. During the experiments, adhesion and activity of fibroblasts cultured on PLLA and PLTMC were studied and compared during two time points of 3 and 5 days. On day 3, the number of adherent fibroblasts was compromised when fibroblasts were cultured in the presence of PLTMC but the proper adherence was recovered by day 5. The same pat-tern was observed when we evaluated some activity parameters of fibroblasts. In particular, the release of proteins and nitric oxide was studied as the increased levels of the mediators might indicate unwanted inflammatory-like condition. Overall, the results suggest that the synthesized PLTMC initially shows unwanted effects on fibroblasts but with the time these effects are abolished. Therefore PLTMC seems to represent a new material that is non-cytotoxic and compatible with the living cells.
Źródło:
Engineering of Biomaterials; 2011, 14, 102; 7-10
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polymer carriers modified by plasma and functionalized with Au nanoparticles as substrates for mouse 3T3 fibroblasts
Autorzy:
Bacakova, M.
Makajova, Z.
Slepickova-Kasalkova, N.
Svorcik, V.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/284032.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
polymers
nanoparticles
fibroblasts
Opis:
Polymers have been o f ten applied in biology and medicine for construction of tissue replacements. However, the inert surface o f the most polymers is not able to support and control cell adhesion, migration, proliferation, differentiation and other cell functions. Hence, the modification of polymer surface led to achieve appropriate properties. The polymer surface can be modified by plasma discharge by which the polymer surface chemistry and morphology is changed. Plasma treatment leads to creation of radicals, unsaturated bonds and new chemical groups, mainly oxygen containing groups. Oxidized groups increase the wettability of polymers, which supports adsorption of cell adhesion-mediating extracellular matrix (ECM) molecules in appropriate spatial conformation increasing accessibility of specific sites in these molecules by cell adhesion receptors. In addition, other surface properties of polymers are altered by plasma etching which strongly influence cell-material interaction. Radicals and unsaturated chemical bonds which are created by plasma can be utilized for grafting new chemical groups, biomolecules and nanoparticles. The biomolecules grafted on the polymer surface, such as amino acids, RGD-containing oligopeptides (i.e., ligands for integrin receptors), ECM molecules, enazymes, hormones, and also carbon and gold nanoparticles, not only have specific biological effects on cells but also change physical and chemical properties of the polymer surface, and by this way they support its bioactivity. This study is focused on physiochemical properties and biocompatibility of modified polymers. The studied materials were poly(L-lactide) (PLLA) foils, nanofibrous PLLA meshes and polyethylene terephtalate (PTFE) foils. PLLA and PTFE foils were modified in plasma with Ar + ions for time intervals of 50, 10 0 and 300 s with power 8 W, and then grafted with Au nanoparticles. Changes in the surface wettability were determined by reflection goniometry . The presence an d concentration o f Au nanoparticles were examine d by X-ray Photoelectron Spectroscopy (XPS). For the biocompatibility testing, the polymers were seeded by mouse embryonic fibroblasts of the line 3T3, i.e., t he cells of ten utilized as a feeder for keratinocytes. The cell adhesion and growth was evaluated by the number of cells, their morphology and the size of cell adhesion area in the 1st, 3rd and 6th day after seeding. The results indicate that the water drop contact angle increases with the time of exposure to plasma, which means that the vettability decreases. However, the following exposure of plasma-irradiated polymers to a sodium citrate solution (i.e., a storage solution for Au nanoparticles) and grafting with Au nanoparticles decrease the contact angle, i.e., increase the material surface wettability. Our tests of biocompatibility indicate that the modification of the polymer surface in fluences positively the cell behavior. The cells adhered at higher numbers and by a larger cell adhesion area on modified polymers; it was mainly manifested on PTFE.
Źródło:
Engineering of Biomaterials; 2011, 14, no. 109-111 spec. iss.; 5
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of surface topography and morphology of PU/PLA films on fibroblasts performance
Autorzy:
Bednarz, P.
Krok, M.
Laska, J.
Powiązania:
https://bibliotekanauki.pl/articles/285206.pdf
Data publikacji:
2012
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
contact angle
roughness
morphology
cell adhesion
fibroblasts
Źródło:
Engineering of Biomaterials; 2012, 15, no. 116-117 spec. iss.; 120-122
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Toksyczność i biokompatybilność wybranych powłok lakierniczych
Toxicity and biocompatibility of selected varnish coatings
Autorzy:
Hajduga, M. A.
Hajduga, M.
Sołek, D.
Jędrzejczyk, D.
Powiązania:
https://bibliotekanauki.pl/articles/99301.pdf
Data publikacji:
2014
Wydawca:
Politechnika Śląska. Katedra Biomechatroniki
Tematy:
fibroblasty
toksyczność
powłoka lakiernicza
cynk
ambulans
fibroblasts
toxicity
varnish coat
zinc
ambulance
Opis:
Karetka pogotowia transportująca pacjentów z chorobami zakaźnymi często może być źródłem kolejnych infekcji. Powodem może być m.in jej specjalna konstrukcja - wąska przestrzeń wewnątrz pojazdu, zbyt słaby system wentylacji oraz specyfika znajdujących się tam urządzeń. Problem ten jest dosyć dobrze znany, ale niewiele danych dotyczy wpływu stanu powierzchni wewnętrznych karetki. Badania były zogniskowane na toksyczności i biozgodności stalowych powierzchni pokrytych różnymi powłokami, które mogą być wykorzystane jako materiał wewnętrznego poszycia pojazdu medycznego.
Ambulance transporting patients with infectious diseases can be also the source of the next infections. Special construction - the narrow space inside, pure quality ventilation system and specific of devices applied inside can be a reason of mentioned problems. This situation is well known, but there is practically no data regarding the influence of internal ambulance surface on observed problem. In our study we focused on toxicity and biocompatibility of steel surface coated with different layers, that can be used as internal material of ambulance.
Źródło:
Aktualne Problemy Biomechaniki; 2014, 8; 45-50
1898-763X
Pojawia się w:
Aktualne Problemy Biomechaniki
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Own experience from the use of a substitute of an allogeneic acellular dermal matrix revitalized with in vitro cultured skin cells in clinical practice
Autorzy:
Łabuś, Wojciech
Kawecki, Marek
Glik, Justyna
Maj, Mariusz
Kitala, Diana
Misiuga, Marcelina
Klama-Baryła, Agnieszka
Kraut, Małgorzata
Nowak, Mariusz
Powiązania:
https://bibliotekanauki.pl/articles/1394264.pdf
Data publikacji:
2015
Wydawca:
Index Copernicus International
Tematy:
acellular dermal matrix ADM
burn
fibroblasts
keratinocytes
tissue engineering
Opis:
As a result of the removal of cells from human allogeneic dermis, a collagen scaffold is obtained, which can be populated de novo with autologous/allogeneic skin cells and transplanted onto the area of skin loss. The optimal method for production of acellular dermal matrices (ADM) has been selected. Three female patients (a mean age of 54 years) were subjected to the transplantation of either autologous or allogeneic keratinocytes and fibroblasts into the holes of acellular dermal matrix (ADM) mesh graft. The method for burn wound treatment based on the use of a viable dermal-epidermal skin substitute (based on ADM and in vitro cultured fibroblasts and keratinocytes) may be the optimal method of burn treatment.
Źródło:
Polish Journal of Surgery; 2015, 87, 10; 513-521
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of fibrin-nanocoating of nanofibrous polymer membranes on the adhesion and proliferation of human dermal fibroblasts
Autorzy:
Pajorova, J.
Bacakova, M.
Musilkova, J.
Stranska, D.
Riedel, T.
Bacakova, L.
Powiązania:
https://bibliotekanauki.pl/articles/284422.pdf
Data publikacji:
2016
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
scaffolds
polymer membranes
fibroblasts
Źródło:
Engineering of Biomaterials; 2016, 19, 138; 48
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of selected flavonoids on glycosaminoglycans in human skin fibroblasts
Autorzy:
Wosek, J.
Kuźmicz, I.
Wiśniewska, R.
Nazaruk, J.
Galicka, A.
Powiązania:
https://bibliotekanauki.pl/articles/1918304.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
Fibroblasts
glycosaminoglycans
flavonoids
Opis:
Purpose: Glycosaminoglycans (GAGs) and proteoglycans (PG) in addition to collagen are the main components of extracellular matrix (ECM). They play an important role in intercellular communication and interactions between cells and ECM. The biological changes in ECM that occur during aging are induced by decrease in GAG biosynthesis. The purpose of this study was to evaluate the effect of selected flavonoids isolated from Cirsium palustre (L.) Scop. on GAG content in human skin fibroblasts. Materials and methods: Human skin fibroblasts were treated with eriodictyol 7-O-glucoside (C1), 6-hydroxyluteolin 7-O-glucoside (C2), scutellarein 7-O-glucoside (C3) and pedalitin (C4) at 1, 20 and 40 μM for 24 h. Concentration of GAGs in the medium was assayed using method based on their ability to bind the cationic dye 1,9- dimethylmethylene blue (DMMB). Results: C1, C2 and C4 at concentration of 20 and 40 µM significantly increased content of sulphated GAGs in the medium. In contrast, treatment of cells with compound C3 did not have a statistically significant impact on GAG level. Ascorbic acid used as a positive control at 50 µM showed no effect on GAG concentration and increased their content at 100 µM but to a much lower extent than flavonoids. Conclusion: Flavonoids C1, C2 and C4 showed greater than ascorbic acid stimulatory impact on GAGs in healthy human skin fibroblasts, demonstrating their therapeutic potential in the aging.
Źródło:
Progress in Health Sciences; 2016, 6(2); 59-63
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of luteolin on expression of epithelial MUC1 mucin in human skin fibroblasts
Autorzy:
Wosek, J.
Radziejewska, I.
Andrulewicz, E.
Powiązania:
https://bibliotekanauki.pl/articles/1918385.pdf
Data publikacji:
2016
Wydawca:
Uniwersytet Medyczny w Białymstoku
Tematy:
fibroblasts
luteolin
MUC1
Opis:
Purpose: The membrane-anchored MUC1 mucin is typically expressed on normal and cancerous epithelial cells. Non-epithelial localization of this mucin is rare. However, the presence of MUC1 in human skin fibroblasts has been recently unexpectedly revealed. The aim of the study was to prove the expression of MUC1 mucin in human skin fibroblasts and the examine of the influence of luteolin on its expression. Materials and methods: ELISA tests and real-time PCR analysis were used to assess the expression of MUC1 mucin in fibroblast cells cocultured with 30 μM concentration of luteolin. Results: The expression of MUC1 was revealed in human skin fibroblasts. Luteolin decreased the relative level of mucin in cell lysates and media. Statistically significant decreased expression of MUC1 gene after luteolin treatment of fibroblasts cells was also revealed. Conclusion: Our results prove non-epithelial localization of MUC1 mucin. Luteolin inhibits the expression of MUC1 mucin in healthy human skin fibroblasts.
Źródło:
Progress in Health Sciences; 2016, 6(2); 64-69
2083-1617
Pojawia się w:
Progress in Health Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characterization of conditions and determination of practical tips for mtDNA level estimation in various human cells
Autorzy:
Jędrak, Paulina
Sowa, Natalia
Barańska, Sylwia
Węgrzyn, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1038562.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
mtDNA level
leukocytes
fibroblasts
qPCR methodology
Huntington disease
Opis:
Determination of mtDNA copy number in the cell is crucial to understand many cellular processes. Recently, the number of studies with the use of mitochondrial DNA (mtDNA) content as the determinant of mitochondrial abnormalities increased greatly and is still growing, therefore, optimization of technical conditions for this analysis is crucial. Despite using similar laboratory protocols, some results cannot be compared between research centers, thus causing discrepancies in the assessment of mtDNA content. The aim of this work was to test which conditions of biological sample collection and storage affect estimation of mtDNA level relative to the nuclear DNA (nDNA) in the blood samples and dermal fibroblasts. We found that the time and temperature of sample storage, as well as the type of the blood sample (whole blood or leukocytes) influence the estimate of mtDNA/nDNA ratio in the blood. In the case of dermal fibroblasts collected from healthy control and Huntington disease patients, our data indicate that the passage number of cells is essential to obtain reliable results.
Źródło:
Acta Biochimica Polonica; 2017, 64, 4; 699-704
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Detonation nanodiamond particles modified by non-steroidal anti-inflammatory drugs in vitro examination
Autorzy:
Mitura, K.
Wilczek, P.
Niemiec-Cyganek, A.
Morenc, M.
Dudek, M.
Sobczyk-Guzenda, A.
Fraczyk, J.
Kolesińska, B.
Powiązania:
https://bibliotekanauki.pl/articles/284974.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
detonation nanodiamond particles
chemical modification
anti-inflammatory drugs
FTIR spectroscopy
mouse fibroblasts
Opis:
Most recently it has been found that nanodiamond particles have very interesting properties. There are number of research communications that detonation nanodiamond particles (NDPs) are fairly reactive and their surface can be effectively modified by chemical methods. The hydroxyl-modified NDPs were obtained by Fenton reaction, amine-functionalized NDPs were obtained by chemical reduction of the nitro- -functionalized surface and carboxyl-modified NDPs by oxidation by using H2O2 under acidic conditions. NDPs functionalized by hydroxyl- and amine- groups and amino groups were used for covalent binding of non-steroidal anti-inflammatory pharmaceuticals (aspirin, ketoprofen, ibuprofen, naproxen) via ester or amide bonds. These results of the studies proved the activity of the conjugates of active substance-NDP and study the rate of release of active substance from the NDPs surface by in vitro examinations with mouse fibroblasts. The progress of the reaction and the characteristics of the products were determined by using FT-IR. Chemical and physical structures of materials were also investigated by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS). DRIFT spectra show the modification of nanodiamond by ketoprofen, naproxen, ibuprofen and aspirin.
Źródło:
Engineering of Biomaterials; 2017, 20, 140; 12-20
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
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